pci for left main coronary artery stenosis · significant unprotected left main coronary artery...
TRANSCRIPT
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PCI for Left Main Coronary Artery Stenosis
Jean Fajadet
Clinique Pasteur, Toulouse, France
Athens, October 19 , 2018
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Significant unprotected left main coronary artery disease occurs in 5-7% of patients undergoing coronary angiography.
The LMS supplies 84% of the blood flow to the LV in a right dominant system (with 16% supplied by the RCA) and 100% of the blood flow to the LV in a left dominant system.
Left Main Coronary Artery Disease
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Plaque is located in the lateral wall (area of low shear stress) while sparing the flow divider region (high shear)
Distribution of the atherosclerotic plaque
Left Main Coronary Artery Disease
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Distribution of plaque in the distal LMCA
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Distal location >70% of cases
Calcified >50% of cases
MVD >70% of cases
Left Main Coronary Artery Disease
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Yusuf et al. Lancet 1994; 344:563
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Lancet 1978;1:263
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Basics for decision-making
ClinicalJudgment
KnowledgeData from RCT’s,
registries, meta-analysis
Guidelines
Experience
Results from local heart team
Global appraisal
of the Patient
Evolution of Technology
&Techniques
Revascularisation for Left Main Lesion
![Page 10: PCI for Left Main Coronary Artery Stenosis · Significant unprotected left main coronary artery disease occurs in 5-7% of patients undergoing coronary angiography. The LMS supplies](https://reader033.vdocuments.net/reader033/viewer/2022042612/5f8194163fc4f5085c0dd59d/html5/thumbnails/10.jpg)
Basics for decision-making
ClinicalJudgment
KnowledgeData from RCT’s,
registries, meta-analysis
Guidelines
Experience
Results from local heart team
Global appraisal
of the Patient
Evolution of Technology
&Techniques
Revascularisation for Left Main Lesion
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Vessel Distribution in LM Population According to Syntax Score Terciles
0-22 33+23-32
66%27%
7%
DistalNondistal
Both59%29%
11%35%
61%
4%
0%
10%
20%
30%
40%
50%
60%
70%
80%
90%
100%
Low Syntax Intermediate
Syntax
High Syntax
LM + 3VD
LM + 2VD
LM + 1VD
LM isolated
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Mohr et al. Lancet 2013; 381: 629–38
SYNTAX – Left Main
MACCE at 5-year follow-up
CABG = 31.0%, PCI = 36.9%, p = 0.12
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Ahn et al. J Am Coll Cardiol 2015;65:2198–206
MACCEDeath of any cause, MI, or stroke
Randomized Trial of Stents Versus Bypass
Surgery for Left Main Coronary Artery Disease5-Year Outcomes of the PRECOMBAT Study
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PCI (%) CABG (%) p value
MACCE 28.3 23 0.045
Death 9.4 11.1 0.27
Cardiac death 6.2 6.8 0.61
MI 5.2 3.2 0.10
Stroke 1.1 2.5 0.06
Death, MI, stroke 14 15.1 0.45
All revascularisation 19.5 10.8 <0.001
Outcomes AfterPCI or CABG in Patients With Unprotected Left Main Disease – Meta analysis of SYNTAX & PRECOMBAT
Cavalcante et al. J Am Coll Cardiol 2016;68:999–1009
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Temporal Trends in Revascularization Strategy and
Outcomes in Left Main Coronary Artery StenosisData From the Asan Medical Center-Left Main Revascularization
Registry
SJ Park et al. Circ Cardiovasc Interv. 2015;8:e001846.
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The new evidence in 2016
NOBLE & EXCEL trials
Left Main Stenosis
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NOBLE study
PCI (Biomatrix, Biolimus) vs CABG
1201 patients
Randomisation: 1 to 1 ratio
LM and no more than 3 additional non complex PCI
lesions
Primary end point:
Composite of all-cause mortality, non procedural
MI, stroke, repeat revasc. (MACCE) at 5 years
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PCI versus CABG in treatment of unprotected left main stenosis (NOBLE): a prospective, randomised, open-label, non-inferiority trial
Mäkikallio et al. Lancet 2016
Primary end point: MACCE at 5 yearsPCI: 29% , CABG: 19%, p=0.0066
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Mäkikallio et al. Lancet 2016
PCI versus CABG in treatment of unprotected left main stenosis (NOBLE): a prospective, randomised, open-label, non-inferiority trial
Mortality Myocardial infarction12% vs 9%, p=0.77 7% vs 2%, p=0.004
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PCI versus CABG in treatment of unprotected left main stenosis (NOBLE): a prospective, randomised, open-label, non-inferiority trial
Repeat revascularisation Stroke16% vs 10%, p=0.032 5% vs 2%, p=0.073
Mäkikallio et al. Lancet 2016
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Kaplan-Meier 5 year estimates of MACCE were
29% for PCI (121 events) and 19% for CABG (81 events),
HR 1·48 (95% CI 1·11–1·96), exceeding the limit for
non-inferiority, and CABG was significantly better than PCI (p=0·0066).
The findings of this study suggest that CABG might be
better than PCI for treatment of left main stem coronary arterydisease.
Mäkikallio et al. Lancet 2016
PCI versus CABG in treatment of unprotected left main stenosis (NOBLE): a prospective, randomised, open-label, non-inferiority trial
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EXCEL study
PCI (Xience, Everolimus) vs CABG
1905 patients
Randomisation: 1 to 1 ratio
Syntax score < 33
Non inferiority trial
Primary end point:
Composite of mortality, MI, stroke at 3 years
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Everolimus-Eluting Stents or Bypass Surgeryfor Left Main Coronary Artery Disease
EXCEL Trial
Stone et al. N Engl J Med, Nov 2016
Primary end point: Death, MI, Stroke at 3 years
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Everolimus-Eluting Stents or Bypass Surgeryfor Left Main Coronary Artery Disease
EXCEL Trial
Stone et al. N Engl J Med, Nov 2016
Components of the Primary end point at 3 years
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In patients with left main coronary artery
disease and low or intermediate SYNTAX scores
by site assessment, PCI with everolimus-eluting
stents was noninferior to CABG with respect
to the rate of the composite end point of death,
stroke, or myocardial infarction at 3 years.
Stone et al. N Engl J Med, Nov 2016
Everolimus-Eluting Stents or Bypass Surgeryfor Left Main Coronary Artery Disease
EXCEL Trial
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PCI (%) CABG (%) p value
Death, stroke, MI 4.9 7.9 0.008
Death 1.0 1.1 0.82
Stroke 0.6 1.3 0.15
MI 3.9 6.2 0.02
Everolimus-Eluting Stents or Bypass Surgeryfor Left Main Coronary Artery Disease
EXCEL Trial
Stone et al. N Engl J Med, Nov 2016
Death, Stroke, MI at 30 days
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PCI (%) CABG (%) p value
Ischemia-driven revasc. 12.6 7.5 <0.001
TVR 10.9 7.2 0.006
non TVR 2.5 0.7 0.004
All revascularisation 12.9 7.6 <0.001
MACCE 23.1 19.1 0.10
Everolimus-Eluting Stents or Bypass Surgeryfor Left Main Coronary Artery Disease
EXCEL Trial
Stone et al. N Engl J Med, Nov 2016
Revascularisation & MACCE
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Comparison between EXCEL (at 3 yrs) and NOBLE (at 5 years)
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EXCEL study NOBLE study
Xience stent Biomatrix Stent
Why different results betweenNOBLE and EXCEL ?
3 years FU 5 years FU
PEP: All MI PEP: Only non procedural MI
PEP without repeat revasc. PEP with repeat revasc.
Positive StudyNon Inferiority of PCI
Negative studyNo Non inferiority of PCI
Mäkikallio et al, Lancet 2016
Stone et al, NEJM 2016
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Basics for decision-making
ClinicalJudgment
KnowledgeData from RCT’s,
registries, meta-analysis
Guidelines
Experience
Results from local heart team
Global appraisal
of the Patient
Evolution of Technology
&Techniques
Revascularisation for Left Main Lesion
![Page 32: PCI for Left Main Coronary Artery Stenosis · Significant unprotected left main coronary artery disease occurs in 5-7% of patients undergoing coronary angiography. The LMS supplies](https://reader033.vdocuments.net/reader033/viewer/2022042612/5f8194163fc4f5085c0dd59d/html5/thumbnails/32.jpg)
Global appraisal of the patient (1)
Clinical characteristics:
Age, gender, cognitive status
Way of life, socio-cultural considerations
Functional class
Diabetes & other risk factors of CAD
Previous cardio-vascular intervention
Valvular disease, heart failure,
COPD,
Renal failure
Peripheral artery disease, carotid artery lesions
Other comorbidities
No contra-indication for long term DAPT
Basics for decision-making
Euroscore
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Global appraisal of the patient (2)
– Angiographic characteristics:• LVEF
• LM lesion: distal /non distal
calcification, bifurcation angle, diseased LCx ostium
trifurcation
• MVD, number of lesions, diffuse disease
• Complexity of additional lesions:
length, calcifications, bifurcations, Syntax score
CTO (RCA occlusion),
• Complete or incomplete revascularisation.
• Number of stents needed, overlapping, complex bifurcations
Basics for decision-making
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SYNTAX score II
Farooq et al. Lancet 2013; 381: 639–50
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Farooq et al. Lancet 2013; 381: 639–50
SYNTAX score II
Prediction of the 4-year mortality
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Basics for decision-making
ClinicalJudgment
KnowledgeData from RCT’s,
registries, meta-analysis
Guidelines
Experience
Results from local heart team
Global appraisal
of the Patient
Evolution of Technology
&Techniques
Revascularisation for Left Main Lesion
![Page 37: PCI for Left Main Coronary Artery Stenosis · Significant unprotected left main coronary artery disease occurs in 5-7% of patients undergoing coronary angiography. The LMS supplies](https://reader033.vdocuments.net/reader033/viewer/2022042612/5f8194163fc4f5085c0dd59d/html5/thumbnails/37.jpg)
• Local experience of the heart team
– Evaluation of local practice: CABG & PCI
– Morbi/mortality meetings
– Share experience in technique & results
– Collegial consensus in patient care
Basics for decision-making
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Basics for decision-making
ClinicalJudgment
KnowledgeData from RCT’s,
registries, meta-analysis
Guidelines
Experience
Results from local heart team
Global appraisal
of the Patient
Evolution of Technology
&Techniques
Revascularisation for Left Main Lesion
![Page 39: PCI for Left Main Coronary Artery Stenosis · Significant unprotected left main coronary artery disease occurs in 5-7% of patients undergoing coronary angiography. The LMS supplies](https://reader033.vdocuments.net/reader033/viewer/2022042612/5f8194163fc4f5085c0dd59d/html5/thumbnails/39.jpg)
• Evolution of the technology & techniques:
– Surgery:• Arterial revasc.
• Midcab
– PCI:• DES: new generation (bioadegradable polymer,
polymer free)
• New antiplatelet agents (prasugrel, ticagrelor)
• Longer DAPT duration
– Hybrid procedures
Basics for decision-making
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Key Features of Contemporary DES
Byrne RA et al. Lancet 2017; 390: 781–92
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0
2
4
6
8
10
All-
ca
use
de
ath
(%
)
BMS Early DES New DES0
2
4
6
8
10
12
14
16
18
20
# M
yo
ca
rdia
l In
farc
tio
n (
%)
BMS Early DES New DES
024
68
101214
1618
2022
24
26
Ta
rge
t-le
sio
n r
eva
scu
lariza
tio
n (%
)
BMS Early DES New DES0
1
2
3
4
5
6
De
fin
ite
ste
nt th
rom
bo
sis
(%
)
BMS Early DES New DES
Death MI
TLR Definite ST
ESC-EAPCI Stent Task Force - Eur Heart J 2015
Safety and efficacy of new generation DES
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How do we evaluate the LM diameter?
1. IVUS
2. Murray’s law, fractal law: D = 0.67 x (d1+d2)
d1
d2
D
Ø= 4.5 – 5mm
Ø=3.5mm
Ø=3.5mm
Visual estimation & QCA are not available
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4.0x8mm DES
Final result after post dilatation
using a 4.5 mm balloon at 22 atm.
Left Main Stenting
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Ostial Left Main Lesion
LAO-cranio viewAP – RAO view
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Direct Stenting
Stent deploymentBalloon post
dilatation
Ostial Left Main Lesion
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Final result
Ostial Left Main Lesion
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Mid-shaft Left Main Lesion
AP – caudal view
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1 stent technique: Provisional stenting
TAP
Culotte
Minicrush, DK Crush
V stenting
Distal Left Main PCI
2-stent technique:
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Strategy of LM stenting: 1 stent vs 2 stents
no lesion at SB ostium
Provisional T stenting: short < 5mm lesion at SB ostium
small SB
Distal Left Main PCI
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Strategy of LM stenting: 1 stent vs 2 stents
poor result after provisional stenting
2-stent strategy: long lesion beyond SB ostium
complex stenosis at SB ostium
diffuse and calcified atheroma
Distal Left Main PCI
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2-stent strategy:
> 60°: T or TAP
Bif. angle
< 60°: Culotte, Minicrush, TAP
MB & SB sizes
Same size Different size
Culotte, TAP Minicrush, TAP
Distal Left Main PCI
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2-stent strategy
One technique must be perfectly known
The TAP technique
Distal Left Main PCI
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TAP technique
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TAP technique
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TAP technique
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TAP technique
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TAP technique
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TAP technique
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TAP technique
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1. Pre dilatation:
balloon,cutting, rotablator
2. Post dilatation:
adequate size balloons with
high pressure
3. KB after 2-stent implantation
4. Final POT
5. Evaluation of the result:
QCA, Stent Boost/Vizz
IVUS
OCT
How to assess & optimize stent deployment
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IVUS for LM ostium evaluation
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Patient selection is key
Global appraisal of the patient (clinical & angiographiccharacteristics)
Good results of PCI in selected patients
Medical-surgical consultation
Ethics of information
Conclusion
LM lesions : PCI or CABG?
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De Maria GL, et al. Heart 2018;104:614–620
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The future …
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