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PCSK9 Loss-of-function Mutations. PCSK9-Mediated Degradation of LDL-R. Evolution of Therapeutic Monoclonal Antibodies. Effect of PCSK9 Inhibitors on LDL-C in Heterozygous FH. DESCARTES % Change in LDL-C From Baseline at Week 52 in Patients With Hypercholesterolemia. - PowerPoint PPT Presentation

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Page 1: PCSK9 Loss-of-function Mutations
Page 2: PCSK9 Loss-of-function Mutations
Page 3: PCSK9 Loss-of-function Mutations

PCSK9 Loss-of-function Mutations

Page 4: PCSK9 Loss-of-function Mutations

PCSK9-Mediated Degradation of LDL-R

Page 5: PCSK9 Loss-of-function Mutations

Evolution of Therapeutic Monoclonal Antibodies

Page 6: PCSK9 Loss-of-function Mutations
Page 7: PCSK9 Loss-of-function Mutations

Effect of PCSK9 Inhibitors on LDL-C in Heterozygous FH

Page 8: PCSK9 Loss-of-function Mutations

DESCARTES% Change in LDL-C From Baseline at Week 52 in Patients With

Hypercholesterolemia

Page 9: PCSK9 Loss-of-function Mutations

GAUSS-1% Change in LDL-C From Baseline at Week 12 in Statin-Intolerant Patients

Page 10: PCSK9 Loss-of-function Mutations

Effect of PCSK9 Monoclonal Antibodies on ApoB and Lp(a)

Page 11: PCSK9 Loss-of-function Mutations

Role of apoB

Page 12: PCSK9 Loss-of-function Mutations

How Low Is Too Low?

Page 13: PCSK9 Loss-of-function Mutations

PCSK9 CV Outcomes Trials

Page 14: PCSK9 Loss-of-function Mutations

TESLATrial Evaluating PCSK9 Antibody in Homozygous FH

Page 15: PCSK9 Loss-of-function Mutations

Abbreviations

Page 16: PCSK9 Loss-of-function Mutations

Abbreviations (cont)

Page 17: PCSK9 Loss-of-function Mutations

References

Page 18: PCSK9 Loss-of-function Mutations

References (cont)

Page 19: PCSK9 Loss-of-function Mutations

References (cont)


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PCSK9 mutations in hypercholesterolemia - bioRxiv...2019/08/22  · PCSK9 mutations in hypercholesterolemia 1 A transient amphipathic helix in PCSK9’s prodomain facilitates low-density

PCSK9 Inhibitors, The Most Significant Advance in Lipid ...Wilson PCSK9 Inhibitors 25 of the first PCSK9 inhibitors in 2015, Repatha (evolocumab) and Praluent (alirocumab) both indicated

EXPERIMENTAL EVOLUTION, LOSS-OF-FUNCTION MUTATIONS, …inbios/Faculty/Behe/PDF/QRB_paper.pdf · experimental evolution, adaptation, mutation, loss of function, malaria, Yersinia pestis

Loss-of-function GJA12/Connexin47 mutations cause ... · PDF fileLoss-of-function GJA12/Connexin47 mutations cause Pelizaeus–Merzbacher-like disease Jennifer L. Orthmann-Murphy,a,⁎