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Paul-‐Lincke-‐Ufer 8c 10999 Berlin
+49151585X855X85 [email protected], skype&twitter&github: @soenkeba
PD DR MED SÖNKE BARTLING
Board certified Radiologist Researcher in basic medical imaging sciences Blockchain for research / Open Science Serendipitist, fueled by intrinsically motivated curiosity
PERSONAL INFORMATION Born: 08/30/1976 in Rinteln an der Weser, Germany
OVERVIEW
STATE DEGREE FROM MEDICAL SCHOOL, MD EQUIVALENT 7/1997 – 5/2004 Hannover Medical School 5/18/2004 Grade: gut (B)
APPROBATION (GERMAN LICENSE TO PRACTICE) 10/01/2004
PROMOTION (DR. MED.) 1/27/2005 “Flachdetektor-‐CT des Felsenbeines/Flat-‐panel detector CT of the temporal bone” Grade: summa cum laude (A)
BOARD CERTIFIED RADIOLOGIST 7/4/2011
HABILITATION (PRIVATDOZENT), ASSISTENT PROFESSOR EQUIVALENT 12/5/2012 Teaching license in diagnostic radiology at Heidelberg University
ATTENDING CLINICAL PHYSICIAN, INCL. INTERVENTIONAL RADIOLOGY -‐ 3/2013 Mannheim University Medical Center, Heidelberg University
HEAD OF WORK GROUP (E014) “PERSONALIZED ONCOTHERAPY” -‐8/2013 German Cancer Research Center
CURRENTLY Founder of Blockchain For Science (blockchainforscience.com)
Advisor (Science & Healthcare) at BlockchainHUB (blockchainhub.net)
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CLINICAL EDUCATION AND MEDICINE
DEPT OF NEURORADIOLOGY (PROF. BECKER), HANNOVER MEDICAL SCHOOL 7/1/2004 – 5/31/2006 Resident, incl. on call
DEPT. OF RADIOLOGY (PROF. KAUFFMANN), HEIDELBERG UNIVERSITY CLINIC 12/1/2006 – 6/30/2007 Resident, incl. whole-‐body ultrasounds
INSTITUTE FOR CLINICAL RADIOLOGY AND NUCLEAR MEDICINE (PROF. SCHÖNBERG), MANNHEIM UNIVERSITY MEDICAL CENTER, HEIDELBERG UNIVERSITY 7/1/2007 – 12/31/2012 Resident, on call service, incl. 6 months mammography, whole-‐body-‐MRI (incl. prostate and cardio), interventional radiology (CT and angiography)
1/1/2013 – 3/31/2013 Chief resident (Funktionsoberarzt), Specializing in CT diagnostic and interventions
4/1/2013 – 3/31/2014 Attending (Oberarzt), incl. whole-‐body-‐MRI and angiographic interventions (PTA, SIRT, TACE, PTCD, emergency embolization), since 4/1/2013 background on call service
INSTITUTE FOR RADIOLOGY AND INTERVENTIONAL THERAPY, VIVANTES AUGUSTE VIKTORIA KLINIKUM 8/1/2015 – 10/31/2015, 7/1/2015-‐9/30/2016 Interims department deputy head (Interims leitender Oberarzt)
DIFFERENT HOSPITALS AND PRIVATE PRACTICE 4/1/2014 until now Freelance radiologist, all kind of diagnostic imaging, interventional therapies, at various positions incl. interim department head in Germany and Switzerland
RESEARCH BASIC MEDICAL IMAGING SCIENCE
DEPT OF NEURORADIOLGY (PROF BECKER), HANNOVER MEDCICAL SCHOOL, IN CLOSE COOPERATION WITH ENT, HANNOVER MEDICAL SCHOOL (PROF. LENARZ) 2000-‐2006, doctorate student and researcher
• Flat-‐panel CT of the Temporal Bone • Intraoperative navigation • Cardiac CT imaging, dynamic CT imaging • Image post-‐processing (MATLAB, ImageJ, 3D Slicer, ...) • CT and MRI image registration and fusion • Cone-‐beam CT reconstruction • Development of stereotactic cochlear implantation: First successful
navigated, minimally-‐invasive cochlea implantation in cadavers
Incl. several research visits:
General Electric R&D (Supervisor Dr. Armin Pfoh), Schenectady, NY, USA, 5 months
Surgical Planning Lab (Supervisor Prof. Ron Kikinis), Brigham and Women´s Hospital, Harvard Medical School, Boston, MA, USA, 6 months
CIMIT (Supervisor Rajiv Gupta, Phd, MD) Massachusetts General Hospital,
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Harvard Medical School, Boston, MA, USA, 1 year
Mentored three medical doctorate students
GERMAN CANCER RESEARCH CENTER, DEPT OF MEDICAL PHYSICS IN RADIOLOGY (PROF. SEMMLER) 2006-‐2013, Research project group leader
4/1/2013-‐7/31/2014 Head of section Personalized Interventional Oncotherapy (E014)
Since 8/1/2014 part time researcher in X-‐ray imaging and computed tomography (Prof. Kachelrieß)
• Small animal imaging using flat-‐panel CT (Prof. Semmler) • Animal experiments (mice, rats) • Molecular imaging (Prof. Kiessling) • Development of macrophage ablation to prevent the uptake of
imaging probes into the RES • Development of CD4-‐targetet CT contrast media • Development of respiratory and cardiac gated flat-‐panel-‐CT, CT image
reconstruction • Image post-‐processing, programming (MATLAB, C++) • Invention and development of 4D intervention guidance using
compressed sensing reconstruction • Development of the PRIDICT image reconstruction algorithm • Early technology assessment of 4D intervention guidance
Mentored one medical technology undergraduate (Diploma) student and one medical technology doctorate student.
INSTITUTE FOR RADIOLOGY AND NUCLEAR MEDICINE, MANNHEIM UNIVERSITY MEDICAL CENTER, HEIDELBERG UNIVERSITY 2007-‐2013, Researcher
1.4.2013-‐31.3.2014, Head of Translational Medicine Section
• Development of first multimodal visible embolization agents • Animal experiments with rabbits and pigs • Translation of compressed sensing based reconstruction algorithms
from basic research to bed side
Mentored three medical doctorate students.
OPEN SCIENCE / BLOCKCHAIN 2005-‐2009 WEB 2.0 FOR SCIENCE, SCIENCE 2.0 Development of concepts and contributions to online discussions, patent applications to assure freedom to operate:
Dynamic publications, micro-‐blogging for science, social network for scientists, green path to open access in social network for scientists
Twitter: @science20
2009-‐2014 OPEN SCIENCE Living, GitHub based book: www.openingscience.org
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SINCE 2014 ‘BLOCKCHAIN’ (R)EVOLUTION IN SCIENCE AND HEALTHCARE A modern machine room for knowledge creation
Twitter: @science_B0
Bartling S, Fecher B (2016). Blockchain for science and knowledge creation. A technical fix to the reproducibility crisis ? Living document/paper (goo.gl/WTWqnG)
Twitter: @healtcareB0
PUBLICATIONS ORIGINAL WORK
Rathmann N, Kostrzewa M, Kara K, Bartling S, Haubenreisser H, Schoenberg SO, et al. Radiation exposure of the interventional radiologist during percutaneous biopsy using a multi-‐axis interventional C-‐arm CT system with 3D laser guidance: a phantom study. Br J Radiol. 2015;88: 20150151. doi:10.1259/bjr.20150151
Socher M, Kuntz J, Sawall S, Bartling S, Kachelrieß M (2014) The retro bulbar sinus is superior to the lateral tail vein for the injection of contrast media in small animal cardiac imaging. Lab Anim 48: 105–113. doi:10.1177/0023677213517500.
Flach B, Kuntz J, Brehm M, Kueres R, Bartling S, Kachelrieß M (2013) Low dose tomographic fluoroscopy: 4D intervention guidance with running prior. Med Phys 40: 101909. doi:10.1118/1.4819826.
Siegert C, Nguyen T, Schubert S, Diehl S, Bartling S, Appel E, Reis C (2013) Production of Multimodal Embolisation Particles -‐ Challenges and Possibilities. Biomed Tech (Berl). doi:10.1515/bmt-‐2013-‐4086.
Kuntz J, Flach B, Kueres R, Semmler W, Kachelrieß M, Bartling S (2013) Constrained reconstructions for 4D intervention guidance. Phys Med Biol 58: 3283–3300. doi:10.1088/0031-‐9155/58/10/3283.
Kuntz J, Gupta R, Schönberg SO, Semmler W, Kachelrieß M, Bartling S (2013) Real-‐time X-‐ray-‐based 4D image guidance of minimally invasive interventions. Eur Radiol. doi:10.1007/s00330-‐012-‐2761-‐2.
Wielpütz MO, Eichinger M, Zhou Z, Leotta K, Hirtz S, Bartling SH, Semmler W, Kauczor H-‐U, Puderbach M, Mall MA (2011) In vivo monitoring of cystic fibrosis-‐like lung disease in mice by volumetric computed tomography. Eur Respir J 38: 1060–1070. doi:10.1183/09031936.00149810.
Bartling SH, Budjan J, Aviv H, Haneder S, Kraenzlin B, Michaely H, Margel S, Diehl S, Semmler W, Gretz N, Schönberg SO, Sadick M (2011) First multimodal embolization particles visible on x-‐ray/computed tomography and magnetic resonance imaging. Invest Radiol 46: 178–186. doi:10.1097/RLI.0b013e318205af53.
Eck W, Nicholson AI, Zentgraf H, Semmler W, Bartling S (2010) Anti-‐CD4-‐targeted gold nanoparticles induce specific contrast enhancement of peripheral lymph nodes in X-‐ray computed tomography of live mice. Nano Lett 10: 2318–2322. doi:10.1021/nl101019s.
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Henzler T, Meyer M, Kalenka A, Alb M, Schmid-‐Bindert G, Bartling S, Schoepf JU, Schoenberg SO, Fink C (2010) Image findings of patients with H1N1 virus pneumonia and acute respiratory failure. Acad Radiol 17: 681–685. doi:10.1016/j.acra.2010.03.013.
Kuntz J, Dinkel J, Zwick S, Bäuerle T, Grasruck M, Kiessling F, Gupta R, Semmler W, Bartling SH (2010) Fully automated intrinsic respiratory and cardiac gating for small animal CT. Phys Med Biol 55: 2069–2085. doi:10.1088/0031-‐9155/55/7/018.
Bäuerle T, Bartling S, Berger M, Schmitt-‐Gräff A, Hilbig H, Kauczor H-‐U, Delorme S, Kiessling F (2010) Imaging anti-‐angiogenic treatment response with DCE-‐VCT, DCE-‐MRI and DWI in an animal model of breast cancer bone metastasis. Eur J Radiol 73: 280–287. doi:10.1016/j.ejrad.2008.10.020.
Neukamm M, Palmowski M, Bartling S, Schawo S, Rietdorf U, Meinzer H-‐P, Hohenfellner M, Kauczor H-‐U, Hallscheidt P (2009) Intrarenal artery delineation with ultra high resolution, flat panel based, volume computerized tomography: outer limits of spatial resolution. J Urol 182: 2915–2919. doi:10.1016/j.juro.2009.08.017.
Aviv H, Bartling S, Kieslling F, Margel S (2009) Radiopaque iodinated copolymeric nanoparticles for X-‐ray imaging applications. Biomaterials 30: 5610–5616. doi:10.1016/j.biomaterials.2009.06.038.
Majdani O, Rau TS, Baron S, Eilers H, Baier C, Heimann B, Ortmaier T, Bartling S, Lenarz T, Leinung M (2009) A robot-‐guided minimally invasive approach for cochlear implant surgery: preliminary results of a temporal bone study. Int J Comput Assist Radiol Surg 4: 475–486. doi:10.1007/s11548-‐009-‐0360-‐8.
Chevessier F, Girard E, Molgó J, Bartling S, Koenig J, Hantaï D, Witzemann V (2008) A mouse model for congenital myasthenic syndrome due to MuSK mutations reveals defects in structure and function of neuromuscular junctions. Hum Mol Genet 17: 3577–3595. doi:10.1093/hmg/ddn251.
Bartling SH, Dinkel J, ,Kuntz J, Grasruck M, Kopp-‐Schneider A, Iwasaki M, Dimmeler S, Gupta R, Semmler W, Kauczor H-‐U, Kiessling F (2008) Intrinsic gating for small-‐animal computed tomography: a robust ECG-‐less paradigm for deriving cardiac phase information and functional imaging. Circ Cardiovasc Imaging 1: 235–243. doi:10.1161/CIRCIMAGING.108.784702.
Bartling SH, Dinkel J, Stiller W, Grasruck M, Madisch I, Kauczor H-‐U, Semmler W, Gupta R, Kiessling F (2008) Intrinsic respiratory gating in small-‐animal CT. Eur Radiol 18: 1375–1384. doi:10.1007/s00330-‐008-‐0903-‐3.
Bäuerle T, Hilbig H, Bartling S, Kiessling F, Kersten A, Schmitt-‐Gräff A, Kauczor H-‐U, Delorme S, Berger MR (2008) Bevacizumab inhibits breast cancer-‐induced osteolysis, surrounding soft tissue metastasis, and angiogenesis in rats as visualized by VCT and MRI. Neoplasia 10: 511–520.
Majdani O, Bartling SH, Leinung M, Stöver T, Lenarz M, Dullin C, Lenarz T (2008) A true minimally invasive approach for cochlear implantation: high accuracy in cranial base navigation through flat-‐panel-‐based volume computed tomography. Otol Neurotol 29: 120–123. doi:10.1097/mao.0b013e318157f7d8.
Majdani O, Bartling SH, Leinung M, Stöver T, Lenarz M, Dullin C, Lenarz T (2008) [Image-‐guided minimal-‐invasive cochlear implantation-‐-‐experiments on cadavers]. Laryngorhinootologie 87: 18–22. doi:10.1055/s-‐2007-‐966775.
Bartling SH, Stiller W, Grasruck M, Schmidt B, Peschke P, Semmler W, Kiessling F (2007) Retrospective motion gating in small animal CT of mice and rats.
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Invest Radiol 42: 704–714. doi:10.1097/RLI.0b013e318070dcad.
Bartling SH, Majdani O, Gupta R, Rodt T, Dullin C, Fitzgerald PF, Becker H (2007) Large scan field, high spatial resolution flat-‐panel detector based volumetric CT of the whole human skull base and for maxillofacial imaging. Dentomaxillofac Radiol 36: 317–327. doi:10.1259/dmfr/19164138.
Bartling SH, Leinung M, Graute J, Rodt T, Dullin C, Becker H, Lenarz T, Stover T, Majdani O (2007) Increase of accuracy in intraoperative navigation through high-‐resolution flat-‐panel volume computed tomography: experimental comparison with multislice computed tomography-‐based navigation. Otol Neurotol 28: 129–134. doi:10.1097/01.mao.0000244364.16826.09.
Arnoldner C, Stöver T, Bartling SH, Windhagen A, Durisin M, Averbeck T, Lenarz T (2006) [Exostosis of the internal auditory canal in a patient with myotonic dystrophy]. Laryngorhinootologie 85: 755–759. doi:10.1055/s-‐2005-‐921214.
Bartling SH, Gupta R, Torkos A, Dullin C, Eckhardt G, Lenarz T, Becker H, Stöver T (2006) Flat-‐panel volume computed tomography for cochlear implant electrode array examination in isolated temporal bone specimens. Otol Neurotol 27: 491–498. doi:10.1097/01.mao.0000194816.15298.50.
Bartling SH, Peldschus K, Rodt T, Kral F, Matthies H, Kikinis R, Becker H (2005) Registration and fusion of CT and MRI of the temporal bone. J Comput Assist Tomogr 29: 305–310.
Gupta R, Bartling SH, Basu SK, Ross WR, Becker H, Pfoh A, Brady T, Curtin HD (2004) Experimental flat-‐panel high-‐spatial-‐resolution volume CT of the temporal bone. AJNR Am J Neuroradiol 25: 1417–1424.
REVIEW & EDUCATIONAL
ICRP, Rehani MM, Gupta R, Bartling S, Sharp GC, Pauwels R, et al. Radiological Protection in Cone Beam Computed Tomography (CBCT). ICRP Publication 129. Ann ICRP. 2015;44: 9–127. doi:10.1177/01466453155754852.
Bartling SH, Kuntz J, Semmler W (2010) Gating in small-‐animal cardio-‐thoracic CT. Methods 50: 42–49. doi:10.1016/j.ymeth.2009.07.006.
Reichardt B, Sarwar A, Bartling SH, Cheung A, Grasruck M, Leidecker C, Bredella MA, Brady TJ, Gupta R (2008) Musculoskeletal applications of flat-‐panel volume CT. Skeletal Radiol 37: 1069–1076. doi:10.1007/s00256-‐008-‐0473-‐0.
Gupta R, Cheung AC, Bartling SH, Lisauskas J, Grasruck M, Leidecker C, Schmidt B, Flohr T, Brady TJ (2008) Flat-‐panel volume CT: fundamental principles, technology, and applications. Radiographics 28: 2009–2022. doi:10.1148/rg.287085004.
Bartling S, Stiller W, Semmler W, Kiessling F (2007) Small animal Computed Tomography Imaging. Current Medical Imaging Reviews 3: 45–59.
Powitzky ES, Hayman LA, Chau J, Bartling SH, Gupta R, Shukla V (2006) High-‐resolution computed tomography of temporal bone: Part IV: Coronal postoperative anatomy. J Comput Assist Tomogr 30: 548–554.
Gupta R, Grasruck M, Suess C, Bartling SH, Schmidt B, Stierstorfer K, Popescu S, Brady T, Flohr T (2006) Ultra-‐high resolution flat-‐panel volume CT: fundamental principles, design architecture, and system characterization. Eur Radiol 16: 1191–1205. doi:10.1007/s00330-‐006-‐0156-‐y.
Powitzky ES, Hayman LA, Bartling SH, Chau J, Gupta R, Shukla V (2006) High-‐resolution computed tomography of temporal bone: Part III: Axial
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postoperative anatomy. J Comput Assist Tomogr 30: 337–343.
Bartling SH, Shukla V, Becker H, Brady TJ, Hayman A, Gupta R (2005) High-‐resolution computed tomography of temporal bone: Part II: coronal preoperative anatomy. J Comput Assist Tomogr 29: 566–569.
Bartling SH, Shukla V, Becker H, Brady TJ, Hayman A, Gupta R (2005) High-‐resolution flat-‐panel volume-‐CT of temporal bone-‐-‐part 1: axial preoperative anatomy. J Comput Assist Tomogr 29: 420–423.
PRE-‐PRINT
Sabel B, Brand K, Bartling S (2014) Macrophage-‐Ablation Significantly Reduces Uptake of Imaging Probe into Organs of the RES. RG preprint DOI: 10.13140/2.1.2301.5682 , in journal submission
Bartling S, Kachelrieß M. X-‐ray tomographic intervention guidance: Towards real-‐time 4D imaging. arXiv: 1610.02959 (arxiv.org/abs/1610.02959) in journal submission
BOOK CHAPTER
Bartling S, Kiessling F. Angiogenese Bildgebung mittels Computertomographie. (2007) In: Mross K, Angioneseinhibition in der Onkologie. Uni-‐Med Verlag, London.
Gupta R, Bartling S, Kalra M, Brady T. Full-‐field cardiac imaging using ultra-‐high resolution flat-‐panel Volume-‐CT. (2007) In: Computed Tomography of the Cardiovascular System. CRC Press, Boca Raton, FL, USA
Bartling S, Semmler W. Data Documentation Systems (2010) In: Kiessling, Pichler, Small animal imaging: Basics and Pratical Guide. Springer, Heidelberg
BOOK
Bartling S, Friesike S (2014) Opening Science. Edition: 2014. New York: Springer. 339 p.
PATENTS (INCL. APPLICATIONS)
Professional DKFZ Invention P-‐756 2006: “Flexible Kontrastmittelstrategie basierend auf Bariumsulfatnanopartikeln”: Beschichtete Bariumsulftatnanopartikel als Kontrastmittel Sönke Bartling, Jürgen Sander, Rolf Danzebrink, Fabian Kiessling, Wolfhart Semmler, Jochen Huppert STATUS: PCT EP2008/050094 NOT INNOVATIVE
Bartling, Kuntz Professional DKFZ Invention P-‐810 2007: “Cardiac gating”, Automatic self-‐gating in small animals STATUS: Preliminary patent application
Bartling, Margel, Aviv Personal invention 2009: MULTIMODAL VISIBLE POLYMER EMBOLIZATION MATERIAL STATUS: German preliminary patent application, PCT application (WO/2011/003902) Several claims considered innovative, novel and commercially applicable by WIPO National phase in the US and Europe
Bartling, Kuntz, Kachelriess Professional DKFZ Invention 2010: Method for 4D radiological intervention guidance (4D-‐CATH) STATUS: US preliminary application PCT application/granted by EPA
Personal invention 2010: Dynamische, wissenschaftliche Publikation Bartling STATUS: German preliminary patent application
ACQUIRED THIRD PARTY FUNDS DFG Schwerpunktprogramm 1124: “Medizinische Navigation und Robotik”
BMBF Innovationswettbewerb 2007: Maßanzug fürs Innenohr
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EEF (Erleichterung der Existenzgründung aus Forschungseinrichtungen) II of
Helmholtz Enterprises: Aniscan
German-‐Israeli Foundation: Synthesis and Characterization of Novel Iodinated Nanoparticles for X-‐Ray CT Lymphography
DFG-‐Normalverfahren: Rekonstruktion mit Vorinformation für Niedrigstdosis CT-‐Fluoroskopie in der interventionellen Radiologie BA 3546/2-‐1
BMBF BIO-‐DISC 7: Tumor therapy platform based on multimodal visible bioactive embolization microspheres
Contribution to BMBF Forschungscampus M2OLIE, Mannheim (Smart embolization agents, novel flat-‐panel detector reconstruction algorithms)
PERSONAL STIPENDS BMEP (BioMedical Sciences Exchange Program) academic year in Boston, MA, supported by a German academic exchange service stipend (DAAD)
Stipend of the ALLIANZ insurance company
German Research Foundation – excellence academy medical technology 2006
AWARDS 2015 Germany land of ideas: “Stadt, Land, Netz” for Opening Science
2013 Intervention award of the German Society of Neuroradiology for the development of 4D intervention guidance
2009 Hans-‐Joachim-‐Denecke-‐Award of the Germanic society for skull base surgery for navigation in the skull base
2005 2nd GE Coolidge Award for the flat-‐panel CT of the temporal bone
2003 2. Posterprice of the European Society of Head and Neck Radiology (ESHNR) 2003
2001 Posterprice of the German Society of ENT
BMEP (BioMedical sciences Exchange Program) akademisches Jahr in Boston, MA, unterstützt durch ein DAAD-Stipendium
Stipendium der ALLIANZ Versicherung
DFG-Excellenzakademie Medizintechnik 2006
GOVERNANCE AND GUIDELINES Member of the task group 88 der ICRP (International Commission of Radiological Protection) “Radiological Protection in Cone Beam CT”
Member of workgroup “Tomographic methods” of the Germany committee for radiation protection in medicine
6-‐12/2003 “Marketing Management” at Harvard Extension School (B+)
Freier Journalist (European Hospital, Hospital Post, Krankenhaus und Management)
MISC 6-‐12/2003 “Marketing Management” at Harvard Extension School (B+)
2 years studies of medical informatics at the remote university in Hagen
Certified for animal experiments (Regierunspräsidium Karlsruhe)
Founding member of new BMEP (Biomedical exchange program)
Member of several national and international professional medical, radiological and interventional societies
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Reviewer of many internationally accepted scientific journals
Reservation and donation of several twitter accounts to scientific organizations, incl. @dkfz