BIO DBMTM

Solutions from Stryker

• Verifiedosteoinductivepotentialpoststerilization1,2

• Graftsterilitypreservedthroughvalidatedsterilizationprocesses1,2

• Multipleformsandsizestoaddressawiderangeofprocedures

References1. Data on file Allosource2. 2Data on file at RTI Surgical, Inc.3. Walsh WR, Oliver R, Yu Y, et al., Demineralized Bone Matrix Provides Equivalent Results to Autograft in Standard Posterolateral Fusion Model in Adult Rabbits. AlloSource White Paper, 2012 4. Lewis, C.S..Hillard, R., Griffith, M., “Evaluation of Stryker BIO DBM and Grafton Matrix PLF,” p. 2

A surgeon must always rely on his or her own professional clinical judgment when deciding whether to use a particular product when treating a particular patient. Stryker does not dispense medical advice and recommends that surgeons be trained in the use of any particular product before using it in surgery. The information presented is intended to demonstrate the breadth of Stryker product offerings. A surgeon must always refer to the package insert, product label and/or instructions for use before using any Stryker product. Products may not be available in all markets because product availability is subject to the regulatory and/or medical practices in individual markets. Please contact your Stryker representative if you have questions about the availability of Stryker products in your area.Stryker Corporation or its divisions or other corporate affiliated entities own, use or have applied for the following trademarks or service marks: BIO DBM, BIO DBM Boat, BIO DBM Putty, BIO DBM Shape. All other trademarks are trademarks of their respective owners or holders. Copyright © 2015 Stryker, Printed in USABIDBM-BR-2

Ordering Information

Product Length Width CC QTY/PackReference NumberBIODBMBoat(Single) 5 cm 2.5cm 10cc 1 65305001BIODBMBoat(Short) 5 cm 2.5cm 20cc 2 653050BIODBMBoat(Long) 10 cm 2.5cm 40cc 2 653100

Product Diameter Height CC QTY/PackReference NumberBIODBMShape 16mm 5mm 1cc1 65401BIODBMShape 25.2mm 5mm 2.5cc 1 65402BIODBMShape 35.7mm 5mm 5cc 1 65405

Description Size Delivery Reference Number

1cc Syringe 7776001

BIODBMGel 5cc Syringe 7776005

10cc Syringe 7776010

1cc Vial 7775001

BIODBMPutty 2.5cc Vial 7775025

5cc Vial 7775005

10cc Vial 7775010

BIODBMPlusPutty 5cc Vial 7777005

(withCancellous) 10cc Vial 7777010

Reconstructive

Hips

Knees

Trauma&Extremities

Foot&Ankle

JointPreservation

Orthobiologics&Biosurgery

MedSurg

PowerTools&SurgicalAccessories

ComputerAssistedSurgery

EndoscopicSurgicalSolutions

IntegratedCommunications

Beds,Stretchers&EMS

Reprocessing&Remanufacturing

Neurotechnology & Spine

Craniomaxillofacial

InterventionalSpine

Neurosurgical,Spine&ENT

Neurovascular

SpinalImplants

Available through: Stryker Spine2 Pearl CourtAllendale, New Jersey 07401

Phone: +1 201 760 8000Fax: +1 201 760 8108www.stryker.com

Spine

BIO DBM Putty,PuttyPlus,andGel• Demonstratedequivalentboneformationresultstoautograft

instandardposteriorlateralfusionmodelinadultrabbits3

• ReversedPhaseMediumCarrierisdesignedtoprovideexcellenthanding

• Formulatedtoresistirrigation• Everylotistestedtoconfirmosteoinductivepotential• PuttyPlusconfigurationscontaincancellousbone1

Control Autograft DBMwithreversephasemedium

Boats• Deeptrough-likedesignengineeredtodeliverlocalbone/

allograftchips• Designedforrapidhydrationandhighvolumeretentionof

bloodorsaline• Longandshortsizesasoptionsforsingleandmulti-level

placementaspartofposterolateralfusionprocedures• 10,20and40ccsizes

Shapes• Easilymoldedintosmallanatomyapplications• Designedforrapidhydrationandhighvolumeretention

ofbloodorsaline• Pliableconsistencyallowsforeasyirrigationof

bone/allograftchips• 1,2.5and5ccsizes

Gel• Syringeinjectable• Easilymoldable• 1,5and10ccsizes

HighOsteoinductivePotential

BIO DBM BoatandShapes

Figure 1. Average percentage of new bone formation for each implant group over 12 weeks. Nine implants across three lots/donors were averaged.

Figure 2. Average bone maturity score for each implant group over 12 weeks. Nine samples across three lots/donors were averaged.

BIO DBMBoatvs.LeadingCompetitionBoththeStrykerBIODBMBoatandOsteotechGraftonMatrixPLFshowhistologicalevidenceofnewboneformationinathymicratectopicpouchmodel.TheboneformationscoresachievedateachtimepointforBIODBMBoatwerecomparabletothoseattainedforGraftonMatrixPLF.2

TheBIODBMBoatgraft,however,reachedhigherlevelsofboneformationatafasterratethantheGraftonMatrixPLgraft.4

BIODBMBoat GraftonMatrixPLF

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Form

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80.00

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60.00

50.00

40.00

30.00

20.00

10.00

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BIODBMBoat GraftonMatrixPLF

Bon

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BIO DBM

Variabilityinallografttissueisalwaysaconcernasnotwodonorsarealike,whichiswhyeachlotofBIODBMPutty,GelandPlusaretestedusingahighlyregardedinvivotesttoconfirmosteoinductivepotential.

DBMcombinedwithareversephasemediumdemonstratedequivalentboneformationresultstoautograftinstandardposteriorlateralfusionmodelinadultrabbits.3

ThreedimensionalreconstructedCTimagesshowevidenceofboneformationinboththeautograftandDBMspecimen.Noboneformationappearsinthecontrolspecimen.Studyshowednostatisticaldifferencewhencomparedtoautograft.

• Naturalbiologicscaffoldtosupportboneingrowth• Sterilizedwithvalidatedtissuesterilizationprocessesthatinclude

viralinactivationsteps2

• Hightoleranceformanipulationandirrigation

Putty and Putty Plus• Vialpackaged• Resistsirrigation• 1,2.5,5and10ccsizes• PuttyPluscontainscancellousbone