peer reviewed research papers 21 26 249 - …glyco/research/peer reviewed... · 15. bundle, d.r....
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PEER REVIEWED RESEARCH PAPERS
1. Bundle, D.R. and Shaw, N. Synthesis of 2-acetamido-6-O-(2-acetamido-2-deoxy-ß-D-
glucopyranosyl)-2-deoxy-D-glucopyranose. Carbohydr. Res., 21, 211-217, 1972.
2. Bundle, D.R., Jennings, H.J. and Kenny, C.P. An improved procedure for the isolation of
meningococcal, polysaccharide antigens, and the structural determination of the antigen from
serogroup X. Carbohydr. Res., 26, 268-270, 1973.
3. Bundle, D.R., Jennings, H.J. and Smith, I.C.P. The carbon-13 nuclear magnetic resonance
spectra of 2-acetamido-2-deoxy-D-hexoses and some specifically deuterated, O-acetylated, and
phosphorylated derivatives. Can. J. Chem., 51, 3812-3819, 1973.
4. Bundle, D.R., Smith I.C.P. and Jennings, H.J. Determination of the structure and conformation
of bacterial polysaccharides by carbon-13 nuclear magnetic resonance. J. Biol. Chem., 249,
2275-2281, 1974.
5. Bundle, D.R., Jennings, H.J. and Kenny, C.P. Studies on the group-specific polysaccharide of
Neisseria meningitidis serogroup X and an improved procedure for its isolation. J. Biol. Chem.,
249, 4797-4801, 1974.
6. Bundle, D.R. and Jennings, H.J. The synthesis of 2-acetamido-2-deoxy--D-glucopyranose 4-
phosphate. Can. J. Biochem., 52, 723-725, 1974.
7. Lemieux, R.U., Bundle, D.R. and Baker, D.A. The properties of a synthetic antigen related to
the human blood group Lewis-a. J. Am. Chem. Soc., 97, 4076-4083, 1975.
8. Lemieux, R.U., Baker, D.A. and Bundle, D.R. A methodology for the production of
carbohydrate-specific antibody. Can. J. Biochem., 55, 507-512, 1977.
9. Jennings, H.J., Bhattacharjee, A.K., Bundle, D.R., Kenny, C.P., Martin, A. and Smith, I.C.P.
Structures of the capsular polysaccharides of Neisseria meningitidis as determined by C-13
nuclear magnetic resonance spectroscopy. J. Infectious Diseases, 136, S78-S83, 1977.
10. Lemieux, R.U., Boullanger, P.A., Bundle, D.R., Baker, D.A. and Venot, A. Binding studies of
-D-galactopyranosyl antibodies. Intramolecular hydrogen bonding effects. Nouveau. J. Chimie,
2, 321-329, 1978
11. Bundle, D.R. and Josephson, S. A facile synthesis of methyl 3,6-dideoxy-L-xylo-
hexopyranoside (colitose). Can. J. Chem., 56, 2686-2690, 1978.
12. Birnbaum, G.I. and Bundle, D.R. Solution conformation and crystal structure of methyl 3,6-
dideoxy--D-ribo-hexopyranoside, an immunodominant sugar of O-antigens. Biochim. Biophys.
Acta, 582, 515-524, 1979.
13. Bundle, D.R. and Josephson, S. Artificial carbohydrate antigen: Synthesis of rhamnose
disaccharides common to Shigella flexneri O-antigen determinants. Can. J. Chem., 57, 662-668,
1979.
14. Bundle, D.R. and Josephson, S. Artificial carbohydrate antigens: The synthesis and
conformation of a Shigella flexneri trisaccharide hapten. J. Chem. Soc., Perkin I, 2736-2739,
1979.
15. Bundle, D.R. Displacement of sugar chlorosulphates by bromide, azide and acetate; a facile
synthesis of methyl, 3,6-dideoxy--D-ribo-hexopyranoside. J. Chem. Soc., Perkin I, 2751-2755,
1979.
16. Bundle, D.R. Antibody to an artificial disaccharide antigen cross-reactive with Neisseria
gonorrhoeae lipopolysaccharide. Can. J. Biochem., 57, 367-371, 1979.
17. Banoub, J. and Bundle, D.R. Stannic tetrachloride catalyzed glycosylation of 8-ethoxy-
carbonyloctanol by cellobiose, lactose and maltose octaacetates; synthesis of and glycosidic
linkages. Can. J. Chem., 57, 2085-2090, 1979.
18. Banoub, J. and Bundle, D.R. 1,2-orthoacetate intermediates in silver trifluoro-
methanesulphonate promoted Koenigs-Knorr synthesis of disaccharide glycosides. Can. J.
Chem., 57, 2091-2097, 1979.
19. Unemura, J., Birnbaum, G.I., Bundle, D.R., Murphy, W.F., Bernstein, H.J. and Mantsch, H.H.
The correlation between O-H stretching frequencies and hydrogen bond distances in a crystalline
sugar monohydrate. Can. J. Chem., 57, 2640-2645, 1979.
20. Josephson, S. and Bundle, D.R. Artificial carbohydrate antigens: The synthesis of the
tetrasaccharide repeating unit of Shigella flexneri O-antigen. Can. J. Chem., 57, 3073-3079,
1979.
21. Bundle, D.R. and Josephson, S. Artificial carbohydrate antigens: The synthesis of tetra-
saccharide hapten, a Shigella flexneri O-antigen repeating unit. Carbohydr. Res., 80, 75-85,
1980.
22. Josephson, S. and Bundle, D.R. Artificial carbohydrate antigens: The synthesis of rhamnose
trisaccharide and disaccharide haptens common to Shigella flexneri O-antigens. J. Chem. Soc.,
Perkin I. 297-301, 1980.
23. Iversen, T. and Bundle, D.R. A new and efficient synthesis of β-L-rhamnopyranosides.
Carbohydr. Res., 84, C13-C15, 1980.
24. Bundle, D.R. and Josephson, S. Chlorosulphation of amino sugars: Synthesis of methyl 2-
acetamido-4-amino-2,4,6-trideoxy--D-glucopyranoside (bacillosamine) from a D-glucosamine
derivative. Can. J. Chem., 58, 2679-2685, 1980.
25. Iversen, T., Josephson, S. and Bundle, D.R. The synthesis of streptococcal groups A, C and
variant-A antigenic determinants. J. Chem. Soc, Perkin I. 2379-2385, 1981.
26. Iversen, T. and Bundle, D.R. Benzyl trichloroacetimidate, a versatile reagent for acid-catalyzed
benzylation of hydroxy-groups. Chem. Comm., 1240-1241, 1981.
27. Iversen, T. and Bundle. D.R. A direct and efficient synthesis of β-L-rhamnopyranosides. J. Org.
Chem., 46, 5389-5393, 1981.
28. Neurohr, K.J., Mantsch, H.H., Young, N.M. and Bundle, D.R. Carbon-13 nuclear magnetic
resonance studies on lectin-carbohydrate interactions: Binding of specifically 13C-labeled
methyl -D-lactoside to peanut agglutinin. Biochemistry, 21, 498-503, 1982.
29. Perry, M.B., Bundle, D.R. Daoust, V. and Carlo D.J. The specific capsular polysaccharide of
Streptococcus pneumoniae type 15F. Mol. Immunol., 19, 235-246, 1982.
30. Bock, K., Josephson, S. and Bundle, D.R. Lipopolysaccharide solution conformation: Antigen
shape inferred from high resolution 1H and 13C nuclear magnetic resonance spectroscopy and
hard-sphere calculations. J. Chem. Soc., Perkin II, 59-70, 1982.
31. Iversen, T. and Bundle, D.R. Antigenic Determinants of Salmonella A and D1 synthesis of
trisaccharide glycosides for use as artificial antigens. Carbohydr. Res., 103, 29-40, 1982.
32. Iversen, T. and Bundle, D.R. Synthesis of the colitose determinant of Escherichia coli 0111 and
3,6-di-O-(-D-galactopyranosyl)--D-glucopyranoside. Can. J. Chem., 60, 299-303, 1982.
33. Neurohr, K.J., Bundle, D.R., Young, N.M. and Mantsch, H.H. Binding of disaccharides by
peanut agglutinin as studied by ultraviolet difference spectroscopy. Eur. J. Biochem., 123, 305-
310, 1982.
34. Bundle, D.R., Gidney, M.A.J., Kassam, N. and Rahman, A.F.R. Hybridomas specific for
carbohydrates; synthetic human blood-group antigens for the production, selection and
characterization of monoclonal typing reagents. J. Immunol., 129, 678-682, 1982.
35. Bhattacharjee, A.K., Bennett, J.E., Bundle, D.R. and Glaudemans, C.P.J. Anticryptococcal type
D antibodies raised in rabbits. Mol. Immunol., 20, 351-359, 1983.
36. Kenne, L., Lindberg, B., Soderholm, E., Bundle, D.R. and Griffith, D.W. Structural studies of
the O-antigens from Salmonella greenside and Salmonella adelaide. Carbohydr. Res., 111, 289-
296, 1983.
37. Pinto, B.M. and Bundle, D.R. Preparation of glycoconjugates for use as artificial antigens: A
simplified procedure. Carbohydr. Res., 124, 313-318, 1983.
38. Wessel, H.P. and Bundle, D.R. Artificial carbohydrate antigens: A block synthesis of a linear
tetrasaccharide repeating unit of the Shigella flexneri variant Y polysaccharide. Carbohydr. Res.,
124, 301-311, 1983.
39. Wessel, H.P., Iversen, T. and Bundle, D.R. Synthesis of the trisaccharide moiety of
gangliotriosylceramide, Asialo GM2. Carbohydr. Res., 130, 5-21, 1984.
40. Caroff, M., Bundle, D. R. and Perry, M. B. Structure of the O-chain of the phenol-phase soluble
cellular lipopolysaccharide of Yersinia enterocolitica serotype O:9. Eur. J. Biochem., 139, 195-
200, 1984.
41. Shearman, P.J., Bundle, D.R., Romanowska, E., Lugowski, C. and Bogulska, M.
Characterization of anti-Citrobacter 036-specific polysaccharide monoclonal antibodies. Can. J.
Microbiol., 30, 91-97, 1984.
42. Carlin, N. I. A., Lindberg, A. A., Bock, K. and Bundle, D. R. The Shigella flexneri O-antigenic
polysaccharide chain: Nature of the biological repeating unit. Eur. J. Biochem., 139, 189-194,
1984.
43. Bock, K., Meldal, M., Bundle, D.R., Iversen, T., Garegg, P.J., Norberg, T., Lindberg, A.A. and
Svenson, S.B. The conformation of Salmonella O-antigenic polysaccharide chains of serogroups
A, B and D1 predicted by semi-empirical hard sphere (HSEA) calculations. Carbohydr. Res.,
130, 23-34, 1984.
44. Bock, K., Meldal, M., Bundle, D.R., Iversen, T., Pinto, B.M., Garegg, P.J., Kvanström, I., Norberg, T., Lindberg, A.A. and Svenson, S.B. The conformation of Salmonella O-antigenic oligosaccharides of serogroups A, B and D1 inferred from 1H and 13C nuclear magnetic
resonance spectroscopy. Carbohydr. Res., 130, 35-53, 1984.
45. Caroff, M., Bundle, D.R., Perry, M.B., Cherwonogrodsky, J.W. and Duncan, J.R. Antigenic S-
type lipopolysaccharide of Brucella abortus 1119-3. Infect. Immun., 46, 384-388, 1984.
46. Bundle, D.R., Gidney, M.A.J., Perry, M.B., Duncan, J.R. and Cherwonogrodzky, J.W.
Serological confirmation of Brucella abortus and Yersinia enterocolitica O:9 O-antigens by
monoclonal antibodies. Infect. Immun., 46, 389-393, 1984.
47. Pinto, B.M. and Bundle, D.R. Antigenic determinant of Salmonella serogroup B. Synthesis of a
trisaccharide glycoside for use as an artificial antigen. Carbohydr. Res., 133, 333-338, 1984.
48. Birnbaum, G.I. and Bundle, D.R. Conformation of methyl 3,6-dideoxy--D-arabino-hexopyranoside, the immunodominant sugar of Salmonella serogroup D1: Crystal structure, 1H NMR analysis and semi-empirical calculations. Can. J. Chem., 63, 739-744, 1985.
49. Gidney, M.A.J., Bundle, D.R., Godard, A. and Griffiths, B.W. Development and
characterization of monoclonal antibodies to pregnancy-specific 1-glycoprotein. Can. J.
Biochem., 63, 737-742, 1985.
50. Wessel, H.P., Iversen, T. and Bundle, D.R. Acid-catalyzed benzylation and allylation by alkyl
trichloroacetimidates. J. Chem. Soc., Perkin I, 2247-2250, 1985.
51. Wessel, H.P. and Bundle, D.R. Strategies for the synthesis of branched oligosaccharides of the
Shigella flexneri 5a, 5b and variant X serogroups employing a multifunctional rhamnose
precursor. J. Chem. Soc., Perkin I, 2251-2260, 1985.
52. Emmrich, F., Bundle, D.R., van der Zee, J., Out, T., Zenke, G. and Eichmann, K. Two human
IgM myeloma proteins with unusual specificities for streptococcal carbohydrate-associated
epitopes. Scand. J. Immunol., 21, 119-126, 1985.
53. Lemieux, R.U., Venot, A.P., Spohr, U., Bird, P., Mandal, G., Morishima, N., Hindsgaul, O. and
Bundle, D.R. Molecular recognition. V. The binding of the B human blood group determinant
by hybridoma monoclonal antibodies. Can. J. Chem., 63, 2664-2668, 1985.
54. Bundle, D.R., Gerken, M. and Perry, M.B. Two dimensional NMR at 500 MHz: The structural
elucidation of a Salmonella serogroup N polysaccharide antigen. Can. J. Chem., 64, 255-264,
1986.
55. Perry, M.B., Bundle, D.R., MacLean, L., Perry, J.A. and Griffith, D.W. The structure of the
antigenic lipopolysaccharide O-chains produced by Salmonella urbana and Salmonella
godesberg. Carbohydr. Res., 156, 107-122, 1986.
56. Carlin, N.I.A., Gidney, M.A.J., Lindberg, A.A. and Bundle, D.R. Characterization of Shigella
flexneri specific murine monoclonal antibodies by chemically defined glycoconjugates. J.
Immunol., 137, 2361-2366, 1986.
57. Pinto, B.M., Morrisette, D.G. and Bundle, D.R. Synthesis of oligosaccharides corresponding to
biological repeating units of Shigella flexneri Y polysaccharide. Part 1. Overall strategy,
synthesis of a key trisaccharide intermediate, and synthesis of a pentasaccharide. J. Chem. Soc.
Perkin I, 9-14, 1987.
58. Bundle, D.R., Cherwonogrodzky, J.W., Caroff, M. and Perry, M.B. The lipopolysaccharides of
Brucella abortus and B. melitensis. Ann. Inst. Pasteur/Microbiol., 138, 92-98, 1987.
59. Sugden, E.A., Samagh, B.S., Bundle, D.R. and Duncan, J.R. Lipoarabinomannan and lipid-free
arabinomannan antigens of Mycobacterium paratuberculosis. Infect. Immun.. 55, 762-770,
1987.
60. Bundle, D.R., Cherwonogrodzky, J.W. and Perry, M.B. The structure of the lipopolysaccharide
O-chain (M antigen) and polysaccharide B produced by Brucella melitensis 16M. FEBS Letters,
216, 261-264, 1987.
61. Carlin, N.I.A., Bundle, D.R. and Lindberg, A.A. Characterization of five Shigella flexneri
variant Y - specific monoclonal antibodies using defined saccharides and glycoconjugate
antigens. J. Immunol., 138, 4419-4427, 1987.
62. Cherwonogrodzky, J.W., Perry, M.B. and Bundle, D.R. Identification of the A and M antigens
of Brucella as the O-polysaccharides of smooth lipopolysaccharides. Can. J. Microbiol., 33, 979-
981, 1987.
63. Altman, E., Brisson, J.-R., Bundle, D.R. and Perry, M.B. Structural studies of the O-chain of
the phenol-phase soluble lipopolysaccharide from Haemophilus pleuropneumoniae serotype 2.
Biochem. Cell Biol., 65, 876-889, 1987.
64. Di Fabio, J.L., Perry, M.B. and Bundle, D.R. Analysis of the lipopolysaccharide of
Pseudomonas maltophilia 555. Biochem. Cell. Biol., 65, 968-977, 1987.
65. Bundle, D.R., Cherwonogrodzky, J.W. and Perry, M.B. Structural elucidation of the Brucella
melitensis M antigen by high resolution NMR at 500 MHz. Biochemistry, 26, 8717-8726, 1987.
66. Gerken, M. and Bundle, D.R. Synthesis of immunologically active oligosaccharide determinants
of the Brucella A antigen: utilization of intermediates derived from methyl 4-azido-4,6-dideoxy-
-D-mannopyranoside. Tet. Lett., 28, 5067-5070, 1987.
67. Peters, T. and Bundle, D.R. Synthesis of 4,6-dideoxy-4-formamido--D- mannose containing
tri- tetra- and pentasaccharides, antigenic determinants of the Brucella A and M antigens. J.
Chem. Soc. Chem. Comm., 1648-1650, 1987.
68. Bundle, D.R., Gerken, M. and Peters, T. Synthesis of antigenic determinants of the Brucella A
antigen utilizing methyl 4-azido-4,6-dideoxy--D-mannopyranoside efficiently derived from D-
mannose. Carbohydr. Res., 174, 239-251, 1988.
69. Bundle, D.R., Cherwonogrodzky, J.W. and Perry, M.B. Characterization of Brucella
polysaccharide B. Infect. Immun., 56, 1101-1106, 1988.
70. Kramer, J.K.G., Sauer, F.D. and Bundle, D.R. The presence of tightly bound Na+ or K+ in
glycolipids in Methanobacterium thermoautotrophicum. Biochim. Biophys. Acta., 961, 285-
292, 1988.
71. Todd, E.C.D., Szabo, R.A., Peterkin, P., Sharpe, A.N, Parrington, L., Bundle, D.R., Gidney,
M.A.J. and Perry, M.B. Rapid hydrophobic grid membrane filter -enzyme labeled antibody
procedure for identification and enumeration of Escherichia coli 0157 in foods. Applied and
Environmental Microbiology, 54, 2536-2540, 1988.
72. Perry, M.B., Bundle, D.R., Gidney, M. A. J. and Lior, H. Identification of Escherichia coli
serotype 0157 strains by using monoconal antibody. J. Clin. Microbiol., 26, 2391-2394, 1988.
73. Kulakowska, M., Lugowski, C., Romanowska, E. and Bundle, D.R. The comparison of
monoclonal-antibodies specific for 2 general epitopes located on citrobacter-036
lipopolysaccharide. Carbohydr. Res., 178, 233-241, 1988.
74. Zygmunt, M.S., Dubray, G., Bundle, D.R. and Perry, M.B. Purified native haptens of Brucella
abortus B19 and B. melitensis 16 M reveal the lipopolysaccharide origin of the antigens. Ann.
Inst. Pasteur/Microbiol., 139, 421-433, 1988.
75. Bundle, D.R. Antibody combining sites and oligosaccharide determinants studied by
competitive binding, sequencing and X-ray crystallography. Pure and Applied Chem., 61, 1171-
1180, 1989.
76. Peters, T. and Bundle. D.R. Synthetic antigenic determinants of the Brucella A polysaccharide;
a disaccharide thioglycoside for block synthesis of pentasaccharide and lower homologues of
1,2-linked 4,6-dideoxy-4-formamido--D-mannose. Can. J. Chem., 67, 491-496, 1989.
77. Peters, T. and Bundle, D.R. Block synthesis of two pentasaccharide determinants of the Brucella
M antigen using thioglycoside methodologies. Can. J. Chem., 67, 497-502, 1989.
78. Pinto, B.M., Reimer, K.B., Morissette, D.G. and Bundle, D.R. Oligosaccharides corresponding
to biological repeating units of Shigella flexneri variant Y polysaccharide. Synthesis and two-
dimensional NMR analysis of a hexasaccharide hapten. J. Org. Chem., 54, 2650-2656, 1989.
79. Nielsen, K., Cherwonogrodzky, J.W., Duncan, J.R. and Bundle, D.R. Enzyme-linked
immunosorbent assay for differentiation of the antibody response of cattle naturally infected with
Brucella abortus or vaccinated with strain 19. Am. J. Vet. Res., 50, 5-9, 1989.
80. Bundle, D.R., Cherwonogrodzky, J.W., Gidney, M.A.J., Meikle, P.J., Perry, M.B. and Peters, T.
Definition of Brucella A and M epitopes by monoclonal typing reagents and synthetic
oligosaccharides. Infect. Immun., 57, 2829-2836, 1989.
81. Meikle, P.J., Perry, M.B., Cherwonogrodzky, J.W. and Bundle, D.R. Fine structure of A and M
antigens from Brucella biovars. Infect. Immun., 57, 2820-2828, 1989.
82. Pinto, B.M., Reimer, K.B., Morissette, D.G. and Bundle, D.R. Oligosaccharides corresponding
to biological repeating units of Shigella flexneri variant Y polysaccharide: Part III. Synthesis
and 2D NMR analysis of a heptasaccharide hapten. J. Chem. Soc. Perkin I, 293-299, 1990.
83. Pinto, B.M., Reimer, K.B., Morissette, D.G. and Bundle, D.R. Synthesis and 2D-n.m.r. analysis
of a pentasaccharide glycoside of the biological repeating units of Shigella flexneri variant Y
polysaccharide and the preparation of a synthetic antigen. Carbohydr. Res., 196, 156-166, 1990.
84. Perry, M.B. and Bundle, D.R. Antigenic relationships in the lipopolysaccharides of strains of
Escherichia hermannii with Escherichia coli 0157:H7, Brucella melitensis and Brucella abortus.
Infect. Immun. 58, 1391-1395, 1990.
85. Peters, T., Brisson, J.-R. and Bundle, D.R. Conformational analysis of key disaccharide
components of Brucella A and M antigens. Can. J. Chem., 68, 979-988, 1990.
86. Kihlberg, J.O., Leigh, D.A. and Bundle, D.R. The in situ activation of thioglycosides with
bromine: An improved glycosylation method. J. Org. Chem., 55, 2860-2863, 1990.
87. Anand, N.N., Dubuc, G., Mandal, S., Phipps, J., Gidney, M.A.J., Sinnott, B., Young, N.M.,
MacKenzie, C.R., Bundle, D.R. and Narang, S.A. Synthesis and expression in Escherichia coli
of DNA encoding the murine 1 chain of a monoclonal antibody specific for Salmonella
serotype B O-antigen. Protein Engineering, 3, 541-546, 1990.
88. Beynon, L.M., Bundle, D.R. and Perry, M.B. The structure of the antigenic lipopolysaccharide
O-chain produced by Escherichia hermanii ATCC 33650 and 33652. Can. J. Chem., 68, 1456-
1466, 1990.
89. Vorberg, E. and Bundle, D.R. Carbohydrate-enzyme conjugates for competitive EIA. J.
Immunol. Meth., 132, 81-89, 1990.
90. Meikle, P.J. and Bundle, D.R. Preparation of polysaccharide enzyme conjugates for competitive
binding assays. Glycoconjugate J., 7, 207-218, 1990.
91. Meikle, P.J., Young, N.M. and Bundle, D.R. O-antigen biotin conjugates: Preparation and use
in direct competitive enzyme immunoassays. J. Immunol. Meth., 132, 255-261, 1990.
92. Rose, D.R., Cygler, M., To, R.J., Przybylska, M., Sinnott, B. and Bundle, D.R. Preliminary
crystal structure determination of an Fab specific for a Salmonella O-polysaccharide antigen. J.
Mol. Biol., 215, 489-492, 1990.
93. Kihlberg, J., Eichler, E. and Bundle, D.R. The design and synthesis of antibody binding site
probes: three pentasaccharide analogues of the Brucella A antigen prepared by in situ activation
of thioglycosides with bromine. Carbohydr. Res., 211, 59-75, 1991.
94. Sigurskjold, B.W., Altman, E. and Bundle, D.R. Sensitive titration microcalorimetric study of
the binding of Salmonella O-antigenic oligosaccharide by a monoclonal antibody. Eur. J.
Biochem., 197, 239-246, 1991.
95. Oomen, R., Young, N.M. and Bundle, D.R. Molecular modeling of antibody-antigen complexes
between the Brucella abortus O-chain polysaccharide and a specific monoclonal antibody.
Protein Engineering, 4, 427-433, 1991.
96. Auzanneau, F.-I. and Bundle, D.R. Incidence and avoidance of stereospecific 1,2-thioethyl
migration during the synthesis of ethyl 1-thio--L-rhamnopyranoside 2,3-orthoester. Carbohydr.
Res., 212, 13-24, 1991.
97. Eichler, E., Kihlberg, J. and Bundle, D.R. Access to fluorescent probes via allyl glycosides; the
synthesis of a Brucella trisaccharide epitope linked to a coumarin. Glycoconjugate J., 8, 69-74,
1991.
98. Kihlberg, J. and Bundle, D.R. The synthesis of antibody binding site probes: A hexasaccharide
and two pentasaccharides related to the Brucella A antigen prepared by in situ activation of
thioglycosides with bromine. Carbohydr. Res., 216, 67-78, 1991.
99. Anand, N.N., Dubuc, G., Phipps, J., MacKenzie, C.R., Sadowska, J., Young, N.M., Bundle, D.R.
and Narang, S.A. Synthesis and expression in Escherichia coli of cistronic DNA encoding an
antibody fragment specific for a Salmonella serotype B O-antigen. Gene, 100, 39-44, 1991.
100. Cygler, M., Rose, D.R. and Bundle, D.R. Recognition of a cell surface oligosaccharide epitope
of pathogenic Salmonella by an antibody Fab fragment. Science, 253, 442-446, 1991.
101. Anand, N.N., Mandal, S., MacKenzie, C.R., Sadowska, J., Sigurskjold, B., Young, N.M.,
Bundle, D.R. and Narang, S.A. Bacterial Expression and Secretion of Various Single-Chain Fv
Genes Encoding Proteins Specific for a Salmonella Serotype B O-Antigen. J. Biol. Chem., 266,
21874-21879, 1991.
102. Narang, S.A., Brummell, D.A., Sharma, V., Bilous, D., Dubuc, G., MacKenzie, C.R.,
Michniewicz, J., Sadowska, J., Anand, N.N., Young, N.M. and Bundle, D.R. Scanning of key
residues in antibody binding sites by two saturation-mutagenesis approaches. Nucleic Acid Res.,
24, 173-179, 1991.
103. Sigurskjold, B. and Bundle, D.R. Thermodynamics of oligosaccharide binding to a monoclonal
antibody specific for a Salmonella O-antigen point to hydrophobic interactions in the binding
site. J. Biol. Chem., 267, 8371-8376, 1992.
104. Reimer, K.B., Gidney, M.A.J., Bundle, D.R. and Pinto, B.M. Immunochemical characterization
of polyclonal and monoclonal streptococcus group A antibodies by chemically defined
glycoconjugates and synthetic oligosaccharides. Carbohydr. Res., 232, 131-142, 1992.
105. Hanna, H.R. and Bundle, D.R. Antibody-oligosaccharide interactions: The synthesis of 2-deoxy-
-L-rhamnose containing oligosaccharide haptens related to Shigella flexneri variant Y antigen.
Can. J. Chem., 71, 125-134, 1993.
106. Auzanneau, F.-I., Hanna, H.R. and Bundle, D.R. The synthesis of chemically modified
disaccharide derivatives of the Shigella flexneri Y polysaccharide antigen. Carbohydr. Res.,
240, 161-181, 1993.
107. Brummell, D.A., Sharma, V.P., Anand, N.N., Bilous, D., Dubuc, G., Michniewicz, J.,
MacKenzie, C.R., Sadowska, J., Sigurskjold, B.W., Sinnott, B., Young, N.M., Bundle, D.R.,
Narang, S.A. Probing the combining site of an anti-carbohydrate antibody by saturation-
mutagenesis: role of the heavy chain CDR3 residues. Biochemistry, 32, 1180-1187, 1993.
108. Vyas, M.N., Vyas, N.K. Meikle, P.J., Sinnott, B., Pinto, B.M., Bundle, D.R. and Quiocho, F.A.
Preliminary crystallographic analysis of a Fab specific for the O-antigen of Shigella flexneri cell
surface lipopolysaccharide with and without bound saccharides. J. Mol. Biol., 231, 133-136,
1993.
109. Auzanneau, F.-I. and Bundle, D. R. Application of thioglycoside chemistry to the synthesis of
trisaccharides and deoxy-trisaccharides related to the Shigella flexneri Y polysaccharide. Can. J.
Chem., 71, 534-548, 1993.
110. Baumann, H., Altman, E. and Bundle, D. R. Controlled acid hydrolysis of an O-antigen
fragment yields univalent heptasaccharide haptens containing one 3,6-dideoxyhexose epitope.
Carbohydr. Res., 247, 347-354, 1993.
111. Auzanneau, F.-I. and Bundle, D.R. Synthesis of chlorodeoxy trisaccharides related to the
Shigella flexneri Y polysaccharide. Carbohydr. Res., 247, 195-209, 1993.
112. Rose, D.R., Przybylska, M., To, R.J., Kayden, C.S., Oomen, R. P., Vorberg, E., Young, N.M.
and Bundle, D.R. Crystal structure to 2.45Å resolution of a monoclonal Fab specific for the
Brucella A cell wall polysaccharide antigen. Protein Science, 2, 1106-1113, 1993.
113. Uhrin, D., Brisson, J.-R. and Bundle, D.R. Pseudo-3D NMR spectroscopy: Application to oligo-
and polysaccharides. J. Biomolecular NMR, 3, 367-373, 1993.
114. Bundle, D.R., Eichler, E., Gidney, M.A.J., Meldal, M., Ragauskas, A., Sigurskjold, B.W.,
Sinnott, B., Watson, D.C., Yaguchi, M. and Young, N.M. Molecular Recognition of a
Salmonella Trisaccharide Epitope by Monoclonal Antibody SE155-4. Biochemistry, 33, 5172-
5182, 1994.
115. Bundle, D.R., Baumann, H., Brisson, J.-R., Gagne, S.M., Zdanov, A. and Cygler, M. The
Solution Structure of a Trisaccharide-Antibody Complex: Comparison of NMR Measurements
with a Crystal Structure. Biochemistry, 33, 5183-5192, 1994.
116. Deng, S.-J., MacKenzie, C.R., Sadowska, J., Michniewicz, J., Young, N.M., Bundle, D.R. and
Narang, S.A. Selection of antibody single-chain Fvs with improved carbohydrate-binding by
phage display. J. Biol. Chem., 269, 9533-9538, 1994.
117. MacKenzie, C.R., Sharma, V., Brummell, D.A., Bilous, D., Dubuc, G., Sadowska, J., Young,
N.M., Bundle, D.R. and Narang, S.A. Effect of C-C domain switching on Fab activity and
yield in Escherichia coli: synthesis and expression of genes encoding two anti-carbohydrate
Fabs. Bio/technology, 12, 390-395, 1994.
118. Zdanov, A., Li, Y., Bundle, D.R., Deng, S.-J., MacKenzie, C.R., Narang S.A., Young, N.M. and
Cygler, M. Structure of a single-chain Fv fragment complexed with a carbohydrate antigen at
1.7Å resolution. Proc. Natl. Acad. Sci (USA), 91, 6423-6427, 1994.
119. Evans, S.V., Rose, D.R., To, R., Young, N.M. and Bundle, D.R. Exploring the mimicry of
polysaccharide antigens by anti-idiotypic antibodies: The crystallization, molecular replacement
and refinement to 2.8Å resolution of an idiotope-anti-idiotope-Fab complex and of the
unliganded-anti-idiotype Fab. J. Mol. Biol., 241, 691-705, 1994.
120. Bundle, D.R. and Eichler, E. Modulation of antibody affinity by synthetic modifications of the
most exposed pyranose residue of a trisaccharide epitope. Bioorgan. Med. Chem., 2, 1221-1229,
1994.
121. Lowary, T.L. and Bundle, D.R. Nucleophile Induced Rearrangements of Thioglycosides:
Formation of 6-Thio Glycosides and 1,6 Thioanhydrosugars Tetrahedron: Asymmetry, 5, 2397-
2404, 1994.
122. Marsden, B.J., Bundle, D.R. and Perry, M.B. Serological and structural relationships between
Escherichia coli O:98 and Yersinia enterocolitica O:11,23 and O:11,24 lipopolysaccharide O-
antigens. Biochem. Cell Biol., 72, 163-168, 1994.
123. Stangier, P., Palcic, M.M. and Bundle, D.R. 2-(Dimethyloctylsilyl)ethyl lactoside: a versatile
intermediate for chemical and enzymic ganglioside synthesis. Carbohydr. Res., 267, 153-159,
1995.
124. Evans, S.V., Sigurskjold, B.W., Jennings, H.J., Brisson, J.-R., To, R., Altman, E., Frosch, M.,
Weisgerber, C., Kratzin, H., Klebert, S., Vaesen, M., Bitter-Suermann, D., Rose, D.R., Young,
N.M. and Bundle, D.R. The 2.8Å resolution structure, and thermodynamics of ligand binding, of
an Fab specific for (28)-polysialic acid. Biochemistry, 34, 6737-6744, 1995.
125. Deng, S.-J., MacKenzie, C.R., Hirama, T., Brousseau, R., Lowary, T., Young, N.M., Bundle,
D.R. and Narang S.A. Basis for selection of improved carbohydrate-binding single-chain
antibodies from synthetic gene libraries. Proc. Natl. Acad. Sci (USA), 92, 4992-4996, 1995.
126. Otter, A., Hindsgaul, O. and Bundle, D. R. Gradient-enhanced homonuclear 2D NMR techniques
applied to oligosaccharides containing manno-hexoses provide improved correlations for protons
coupled by small 3J. Carbohydr. Res., 275, 381-389, 1995.
127. Otter A. and Bundle, D.R., Long Range 4J and 5J Including Inter-Glycosidic Correlations in
Gradient-Enhanced Homonuclear COSY Experiments of Oligosaccharides. J. Mag. Reson. Ser.
B, 109, 194-201, 1995.
128. Lowary, T., Eichler, E. and Bundle, D.R. Synthesis of a pentasaccharide epitope for the
investigation of carbohydrate-protein interactions. J. Org. Chem., 60, 7316-7327, 1995.
129. MacKenzie, C.R., Clark, I.D., Evans, S.V., Hill, I.E., MacManus, J.P., Dubuc, G., Bundle, D.R.,
Narang S.A., Young, N.M. and Szabo, A.G. Bifunctional fusion proteins consisting of a single-
chain antibody and an engineered lanthanide-binding protein. Immunotechnology, 1, 139-150,
1995.
130. Seto, N.O.L., Palcic, M.M., Hindsgaul, O., Bundle, D.R. and Narang, S.A. Expression of a
recombinant human glycosyltransferase from a synthetic gene and its utilization for synthesis of
the human blood group B trisaccharide. Eur. J. Biochem., 234, 323-328, 1995.
131. MacKenzie, C.R., Hirama, T., Deng, S.-J., Bundle, D.R., Narang S.A. and Young, N.M.
Analysis by surface plasmon resonance of the influence of valence on the ligand binding affinity
and kinetics of an anti-carbohydrate antibody. J. Biol. Chem., 271, 1527-1533, 1996.
132. Zhang, J., Otter A. and Bundle D.R. Synthesis and Conformational Studies of the Tyvelose
Capped, Lewis-x Like Tetrasaccharide Epitope of Trichinella spiralis. Bioorgan. Med. Chem., 4,
1989-2001, 1996.
133. Probert, M.A., Zhang, J. and Bundle D.R. Synthesis of and linked Tyvelose Epitopes of the
Trichinella spiralis glycan; 2-Acetamido-2-deoxy-3-O-(3,6-dideoxy-D-arabino-hexopyranosyl)-
-D-galactopyranosides. Carbohydr. Res., 296, 149-170, 1996.
134. Ellis, L.A., McVay, C.S., Probert, M.A., Zhang, J., Bundle, D.R. and Appleton J.A. Terminal -
linked tyvelose creates unique epitopes in Trichinella spiralis glycan antigens. Glycobiology, 7,
383-390, 1997
135. Seto, N.O.L., Palcic, M.M., Compston, C.A., Li, H., Bundle, D.R. and Narang, S.A. Sequential
interchange of four amino acids from blood group B to blood group A glycosyltransferase boosts
catalytic activity and progressively modifies substrate recognition in human recombinant
enzymes. J. Biol. Chem., 272, 14133-14138, 1997.
136. Stangier, K., Palcic, M.M., Bundle, D.R., Hindsgaul, O. and Thiem, J. Fucosyltransferase-catalyzed formation of L-galactosylated Lewis structures. Carbohydr. Res., 305, 511-515, 1998.
137. Kitov, P.I., Railton, C. and Bundle, D.R. The synthesis of 16-mercaptohexadecanyl glycosides
for biosensor applications. Carbohydr. Res., 307, 361-369, 1998.
138. Bundle, D.R., Alibes, R., Nilar, S., Otter, A., Warwas, M. and Zhang, P. Thermodynamic and
conformational implications of glycosidic rotamers pre-organized for binding. J. Am. Chem.
Soc., 120, 5317-5318, 1998.
139. Alibes, R. and Bundle, D.R. Synthesis of tethered trisaccharides to probe inter-saccharide
flexibility in carbohydrate-protein interactions. J. Org. Chem., 63, 6288-6301, 1998.
140. Otter, A., Lemieux, R.U., Ball, R.G., Venot, A.P., Hindsgaul, O. and Bundle, D.R. Crystal State
and Solution Conformation of the Blood Group B Trisaccharide -L-Fucp-(12)-[ -D-Galp]-
(1 3)]--D-Galp-OCH3 Eur. J. Biochem., 259, 295-303, 1999.
141. Schriemer, D.C., Bundle, D.R., Li, L. and Hindsgaul, O. Micro-scale frontal affinity
chromatography: a new method for screening of compound libraries. Angew. Chem. Int. Ed. 37,
3383-3387, 1999.
142. Milton, M.J. and Bundle D.R. Observation of the anti- conformation of a glycosidic linkage in
an antibody bound oligosaccharide. J. Am. Chem. Soc., 120, 10547-10548, 1998.
143. Seto, N.O.L., Compston, C.A., Evans, S. V., Bundle, D.R., Narang, S.A. and Palcic, M.M.
Donor Substrate Specificity of Recombinant Human Blood Group A, B and Hybrid A/B
Glycosyltransferases Expressed In Escherichia coli. Eur. J. Biochem. 259, 770-775, 1999.
144. Young, N.M., Gidney, M.A.J., Gudmundsson, B.M.E., MacKenzie, C.R., To, R., Watson, D.C.
and Bundle, D.R. Molecular basis for the lack of mimicry of Brucella polysaccharide antigens
by Ab2 antibodies. Mol. Immunol., 36, 339-347, 1999.
145. Wacowich-Sgarbi, S.A. and Bundle, D.R. Constrained H-Type 2 Blood Group Trisaccharide
Synthesized in a Bioactive Conformation via Intramolecular Glycosylation,
J. Org. Chem., 64, 9080-9089, 1999.
146. Yu, H.N., Zhang, P., Ling, C.-C. and Bundle, D.R. A practical route to 3,6-dideoxyhexoses.
Tetrahedron Asymmetry, 11, 465-479, 2000.
147. Kitov, P.I., Sadowska, J.M., Mulvey, G., Armstrong, G.D., Ling, H., Pannu, N.S., Read, R.J. and
Bundle, D.R. Shiga-like toxins neutralized by tailored multivalent carbohydrate ligands. Nature,
403, 669-672, 2000.
148. Alexander, J., del Guercio, M-F., Maewal, A., Qiao, L., Filkes, J. Chesnut, R.W., Paulson, J.C.,
Bundle, D,R., DeFrees, S. and Sette, A. Linear PADRE T Helper Epitope and Carbohydrate B
Cell Epitope Conjugates Induce Specific High Titer IgG Antibody Responses. J. Immunol. 164,
1625-1633, 2000.
149. Nitz, M. and Bundle, D.R. Efficient synthesis of 3,6-dideoxy--D-arabinohexopyranosyl
terminated LacdiNac glycan chains of the Trichinella spiralis parasite. J. Org. Chem., 65, 3064-
3073, 2000.
150. Nitz, M., Purse B.W. and Bundle, D.R. Synthesis of a 1,2-mannopyranosyl tetrasaccharide
found in the phosphomannan antigen of Candida albicans. Org. Let., 2, 2939-2942, 2000.
151. Zhang, P. and Bundle, D.R. Synthesis of three tethered trisaccharides to probe entropy
contributions in carbohydrate-protein interactions. Israel J. Chem., 40, 189-207, 2000.
152. Yu, H.N., Ling, C.-C. and Bundle, D.R. Efficient stereoselective synthesis of 1-thio--
mannopyranosides. JCS Perkin 1, 832-837, 2001.
153. Kitov, P.I. and Bundle, D.R. Synthesis and structure-activity relationships of di- and
trisaccharide inhibitors for Shiga-like toxin Type 1. JCS Perkin 1, 838-853, 2001.
154. Kitova, E.N., Kitov, P.I., Bundle D.R. and Klassen, J.S. The observation of multivalent
complexes of Shiga-like toxin with globotrioside and the determination of their stoichiometry by
nanoelectrospray Fourier-transform ion cyclotron resonance mass spectrometry. Glycobiology,
11, 605-611, 2001.
155. Wacowich-Sgarbi, S.A., Ling, C.C., Otter, A. and Bundle, D.R. A tethered disaccharide trapped
as its anti conformer calibrates the Karplus relationship for 3JC,H coupling constants. J. Am.
Chem. Soc., 123, 4362-4363, 2001.
156. Kitov, P.I. and Bundle, D.R. Mild oxidative one-pot allyl group cleavage. Org. Let., 3, 2835-
2838, 2001.
157. G. Mulvey, P.I. Kitov, P. Marcato, D.R. Bundle and G.D. Armstrong. Glycan mimicry as a basis
for novel anti-infective drugs. Biochimie, 83, 841-847, 2001.
158. Nitz, M. and Bundle, D.R. Synthesis of di- to hexasaccharide 1,2-linked -mannopyranan
oligomers, a terminal S-linked tetrasaccharide congener and the corresponding BSA
glycoconjugates. J. Org. Chem., 66, 8411- 8423, 2001.
159. Appleton, J.A., Dell, A., Nitz, M. and Bundle, D.R. Novel N-glycans of the parasitic nematode
Trichinella spiralis. Trends in Glycoscience and Glycotechnology, 13, 481-492 (2001).
160. Nitz, M., Ling, C. C., Otter, A., Cutler, J. E. and Bundle, D. R. The unique solution structure and
immunochemistry of the Candida albicans -1,2-mannopyranan cell wall antigen. J. Biol. Chem.
277, 3440-3446, 2002.
161. Soltyk, A. M., MacKenzie, C. R., Wolski, V. M., Hirama, T., Kitov, P. I., Bundle, D. R. and
Brunton, J. L. A mutational analysis of the globotriaosylceramide binding sites of verotoxin
VT1. J. Biol Chem., 277, 5351-5359, 2002.
162. Kitova, E.N., Bundle, D.R. and Klassen, J.S. Thermal Dissociation of Protein-Oligosaccharide
Complexes in the Gas Phase: Mapping the Intrinsic Intermolecular Interactions. J. Am. Chem.
Soc., 124, 5902-5913, 2002.
163. Zhang, P., Appleton, J.A., Ling, C.C. and Bundle, D.R. Synthesis of disaccharide congeners of
the Trichinella spiralis glycan and binding site mapping of two protective antibodies. Canad. J.
Chem. 80, 1141-1161, 2002.
164. Lowary, T.L., Eichler, E. and Bundle, D.R.. Oligosaccharide recognition by antibodies: synthesis
and evaluation of talose oligosaccharide analogues. Canad. J. Chem. 80, 1112-1130, 2002.
165. Yu, H.N., Ling, C.-C. and Bundle, D.R. Probing Carbohydrate-Antibody Interactions: Synthesis
of Three Salmonella Epitopes for SPR Studies. Canad. J. Chem. 80, 1131-1140 2002.
166. Uhrín, D., Prasad, A.V.K., Brisson, J.R. and Bundle, D.R. Carbohydrate-Antibody Interactions
by NMR. Antibody interactions by NMR. Canad. J. Chem. 80, 904-907, 2002.
167. Vyas, N.K., Vyas, M.N., Chervenak, M.C., Johnson,
M.A., Pinto, B.M., Bundle, D.R. and
Quiocho, F.A. Molecular Recognition of Oligosaccharide Epitopes by a Monoclonal Fab
Specific for Shigella flexneri Y Lipopolysaccharide: X-ray Structures and Thermodynamics.
Biochemistry 41, 13575-13586, 2002.
168. Kitova, E.N., Bundle, D.R. and Klassen, J.S. Evidence for the Preservation of Specific
Intermolecular Interactions in Gaseous Protein-Oligosaccharide Complexes. J. Am. Chem. Soc.,
124, 9340-9341, 2002.
169. Kitova, E.N., Wang, W., Bundle, D.R. and Klassen, J.S. Retention of Bioactive Ligand
Conformation in a Gaseous Protein-Trisaccharide Complex. J. Am. Chem. Soc., 124, 13980-
13981, 2002.
170. Mulvey, G.L., Marcato, P., Kitov, P.I., Sadowska, J., Bundle, D.R. and Armstrong, G.D.
Assessment in Mice of the Therapeutic Potential of tailored, Multivalent Shiga Toxin
Carbohydrate Ligands. J. Infect. Dis., 187, 640-649, 2003.
171. Kitov, P.I., Shimizu, H., Homans, S.W. and Bundle, D.R. Optimization of Tether Length in non-
Glycosidically Linked Bivalent Ligands that Target Sites 2 and 1 of Shiga-like Toxin. J. Am.
Chem. Soc., 125, 3284-3294, 2003.
172. Kamath, V., Sadowska, J., Nilar, S., Bundle, D.R., Hindsgaul, O. Synthetic analogs of the
Lewisb-tetrasaccharide and their binding to the lectin GS-IV – Part 1. Synlett, 1327-1330, 2003.
173. Yung, A.,Turnbull, B., Kalverda, A., Thompson, G., Homans, S., Kitov, P.I. and Bundle, D.R.
Large scale millisecond inter-subunit dynamics in the B subunit homopentamer of the toxin
derived from E. coli O157. J. Am. Chem. Soc., 125, 13058-13062, 2003.
174. Kitov, P.I. and Bundle, D.R. On the Nature of the Multivalency Effect: A Statistical
Thermodynamic Model J. Am. Chem. Soc., 125, 16271-16284, 2003.
175. Vyas, N.K., Vyas, M.N., Chervenak, M.C., Bundle, D.R., Pinto, B.M. and Quiocho, F.A.
Structural basis of peptide-carbohydrate mimicry in an antibody-combining site. Proc. Natl.
Acad. Sci (USA), 100, 15023-15028, 2003.
176. Rich, J.R., Szpacenko, A., Palcic, M.M. and Bundle, D.R. Glycosyltransferase catalyzed
synthesis of thiooligosaccharides. Angew. Chem. Int. Ed., 43, 613-615, 2004.
177. Willison, H.J., Townson, K., Veitch, J., Boffey, J., Isaacs, N. andersen, S., Zhang, P., Ling, C.-C.
and Bundle, D.R. Synthetic disialylgalactose immunoadsorbents deplete anti-GQ1b antibodies
from neuropathy sera. Brain, 127, 680-691, 2004.
178. Andersen, S., Ling, C.-C., Zhang, P., Townson, K., Willison, H.J. and Bundle, D.R. Synthesis of
ganglioside epitopes for oligosaccharide specific immunoadsorption therapy of Guillian Barré
syndrome. Org. Biomol. Chem., 2, 1199 – 1212, 2004.
179. Kitova, E., Bundle, D.R. and Klassen, J.S. Partitioning of solvent effects and intrinsic
interactions in biological recognition. Angew. Chem. Int. Ed., 43, 4183-4186, 2004.
180. Rich, J. and Bundle, D.R. S-Linked ganglioside analogues for use in conjugate vaccines. Org.
Lett., 6(6), 897-900, 2004.
181. Wu, X., Ling, C.-C. and Bundle, D.R. A New Homobifunctional p-Nitro Phenyl Ester Coupling
Reagent for the Preparation of Neoglycoproteins. Org. Lett., 6(24), 4407-4410, 2004.
182. Gagne, R.A., McGavin, R.S., Chervenak, M.C. and Bundle, D.R. The design, synthesis and
evaluation of high affinity macrocyclic carbohydrate inhibitors. Org. Biomol. Chem., 3, 2723-
2732, 2005.
183. McGavin, R.S. and Bundle, D.R. Developing high affinity oligosaccharide inhibitors:
conformational pre-organization paired with functional group modification. Org. Biomol. Chem.,
3, 2733-2740, 2005.
184. Ho, J.G.S., Kitov, P.I., Paszkiewicz, E., Sadowska, J., Bundle, D.R. and. Ng, K.K.-S. Ligand-
assisted aggregation of proteins: dimerization of serum amyloid P component by bivalent
ligands. J. Biol. Chem., 280, 31999-32008, 2005.
185. Wu, X. and Bundle, D.R. Synthesis of glycoconjugate vaccines for Candida albicans using novel
linker methodology. J. Org. Chem., 70, 7381-7388, 2005.
186. Cai, Y., Ling, C.-C. and Bundle, D. R. A facile approach to 2-acetamido-deoxy--D-
glucopyranosides via the furanosyl oxazoline. Org. Lett., 7, 4021-4024, 2005.
187. Solomon, D., Kitov, P. I., Paszkiewicz, E., Grant, G. A., Sadowska, J. M.. and Bundle, D. R.
Hetero-bifunctional multivalent inhibitor-adaptors mediate specific aggregation between shiga
toxin and a pentraxin. Org. Lett., 7, 4369-4372, 2005.
188. Kanda, V. Kitov, P.I., Bundle, D.R. and McDermott, M.T. Surface plasmon resonance imaging
measurements of the inhibition of Shiga-like toxin by synthetic multivalent inhibitors. Anal.
Chem. 77, 7497-7504, 2005.
189. Bundle, D.R. Rich, J.R., Jacques, S., Yu, H.N., Nitz, M. and Ling, C.-C. Thio-oligosaccharide
conjugate vaccines evoke antibodies specific for native antigens. Angew. Chem. Int. Ed., 44,
7725-7729, 2005.
190. Rich, J.R., Wakarchuk, W.W. and Bundle, D.R. Chemical and chemoenzymatic synthesis of S-
linked ganglioside analogues and their protein conjugates. Immunogens with improved in vivo
availability? Chem. Eur. J., 12, 845-858, 2006.
191. Jacques, S., Rich, J.R., Ling, C.-C. and Bundle, D.R. Chemoenzymatic synthesis of GM3 and
GM2 gangliosides containing a truncated ceramide functionalized for glycoconjugate synthesis
and solid phase applications. Org. Biomol. Chem., 4, 142-154, 2006.
192. Cai, Y., Ling, C.-C. and Bundle, D.R. A general, efficient and stereospecific route to
sphingosine, sphinganines, phytosphingosines and their analogs. Org. Biomol. Chem., 4, 1140-
1146, 2006.
193. Bundle, D.R. Nitz, M., Wu, X. and Sadowska, J.M. A uniquely small, protective carbohydrate
epitope may yield a conjugate vaccine for Candida albicans. Amer. Chem. Soc., Symp. Ser., 989,
163-183, 2007.
194. Townson, K., Boffey, J., Nicholl, D., Veitch, J., Bundle, D.R., Zhang, P., Samain, E., Antoine,
T., Bernardi, A., Arosio, D., Sonnino, S., Isaacs, N. and Willison, H.J. Solid phase
immunoadsorption for therapeutic and analytical studies on neuropathy-associated anti-GM1
antibodies. Glycobiology, 17, 294–303, 2007.
195. Kitova, E.N., Kitov, P.I., Paszkiewicz, E., Kim, J., Mulvey, G.L., Armstrong, G.D., Bundle, D.R.
and Klassen, J.S. Affinities of Shiga Toxins 1 and 2 for Univalent and Oligovalent Pk
Trisaccharide Analogs Measured by Electrospray Ionization Mass Spectrometry. Glycobiology,
17, 1156-1166, 2007.
196. Wu, X., Lipinski, T., Carrell, F., Bailey, J. J., and Bundle, D. R. Synthesis and Immunochemical
Studies on a Candida albicans Clustered Glycoconjugate Vaccine. Org. Biomol. Chem., 5, 3477
– 3485, 2007.
197. Moore, S. L., Uitz, C., Ling, C.-C., Bundle, D. R., Fusco P. C. and Michon, F. Epitope
Specificities of the Groups Y and W-135 Polysaccharides of Neisseria meningitides. Clinical
and Vaccine Immunology, 14, 1311-1317, 2007.
198. Kitov, P. I., Lipinski, T., Paszkiewicz, E., Solomon, D., Sadowska, J. M., Grant, G. G. A.,
Mulvey, G. L., Kitova, E. N., Klassen, J. S., Armstrong, G. D. and Bundle, D. R. An
Entropically Efficient Supramolecular Inhibition Strategy for Shiga Toxins. Angew. Chemie Intl.
Ed., 47, 672-676, 2008.
199. O’Reilly, M. K., Collins, B. E., Han, S., Liao, L., Rillahan, C. Kitov, P. I., Bundle, D. R. and
Paulson, J. C. Bi-functional CD22 ligands use multimeric immunoglobulins as protein scaffolds
in assembly of immune complexes on B cells. J. Am. Chem. Soc., 130, 7736-7745, 2008.
200. Dziadek, S., Jacques, S. and Bundle, D. R. A novel linker methodology for the synthesis of
tailored conjugate vaccines composed of complex carbohydrate antigens and specific TH-cell
peptide epitopes. Chem. Eur. J., 14, 5908-5917, 2008.
201. Wu, X., Lipinski, T., Paszkiewicz, E. and Bundle, D. R. Synthesis and immunochemical
characterization of S-linked glycoconjugate vaccines against Candida albicans
Chem. Eur. J., 14, 6474-6482, 2008.
202. Xin , H., Dziadek, S., Bundle, D. R. and Cutler, J. Synthetic glycopeptide vaccines combining β-
mannan and peptide epitopes induce protection against candidiasis. Proc. Natl. Acad. Sci (USA),
105, 13526-13531, 2008.
203. Kitov, P. I., Mulvey, G. L., Griener, T., Lipinski, T., Solomon, D., Paszkiewicz, E., Jacobson, J.
, Sadowska, J. M., Suzuki, M., Yamamura, K., Armstrong, G. D. and Bundle, D. R. In vivo
supramolecular templating enhances the activity of multivalent ligands: A potential therapeutic
against the E. coli O157 AB5 toxins. Proc. Natl. Acad. Sci (USA), 105, 16837-16842, 2008.
204. Grant, C.F., Kanda, V., Yu, H., Bundle, D.R. and McDermott, M.T. Optimization of
Immobilized Bacterial Disaccharides for Surface Plasmon Resonance Imaging Measurements of
Antibody Binding. Langmuir, 24, 14125–14132, 2008.
205. Cai, Y., Ling, C.-C. and Bundle, D.R. Concise and efficient synthesis of 2-acetamido-2-deoxy-β-
D-hexopyranosides of diverse aminosugars from 2-acetamido-2-deoxy-β-D-glucose. J. Org.
Chem., 74, 580–589, 2009.
206. Nycholat, C.M., and Bundle, D.R. Synthesis of mono-deoxy and mono-O-methyl congeners of
methyl β-D-mannopyranosyl-(12)-β-D-mannopyranoside for epitope mapping of anti-Candida
albicans antibodies. Carbohydr. Res., 344, 555-569, 2009.
207. Cai, Y., Ling, C.-C. and Bundle, D.R. Efficient Synthesis of D-xylo and D-ribo-
Phytosphingosines from methyl 2-amino-2-deoxy-β-D-hexopyranosides. Carbohydr. Res., 344,
2120-2126, 2009.
208. Hu, J., Huang, X., Ling, C.-C., Bundle, D.R. and Cheung, N.K. Reducing Epitope Spread during
Affinity Maturation of an Anti-Ganglioside GD2 Antibody. J. Immunol., 183, 5748 – 5755,
2009.
209. Wu, X., Cui, L., Lipinski, T. and Bundle, D.R. Synthesis of monomeric and
dimeric repeating units of the zwitterionic type 1 capsular polysaccharide
from Streptococcus pneumoniae. Chem. Eur. J., 16, 3476-3488, 2010.
210. Iynkkaran, I. and Bundle, D. R., A novel glycosyl donor for synthesis of 2-acetamido-4-amino-
2,4,6-trideoxy-α-D-galactopranosides. Carbohydr. Res., 345, 2323-2327, 2010.
211. Huang, J., Motto D. G., Bundle, D. R. and Sadler, J. E. Shiga toxin B subunits induce VWF
secretion by human endothelial cells and thrombotic microangiopathy in ADAMTS13-deficient
mice. Blood, 116, 3653-3659, 2010.
212. Lipinski, T., Kitov, P., Szpacenko, A., Paszkiewicz, E. and Bundle, D. R. Synthesis and
Immunogenicity of a Glycopolymer Conjugate. Bioconjug. Chem., 22, 274-281, 2011.
213. Tran, H.-A., Kitov, P. I., Paszkiewicz, E., Sadowska, J. M. and Bundle, D. R. Multifunctional
multivalency: a focused library of polymeric cholera toxin antagonists. Org. Biomol. Chem., 9,
3658-3671, 2011.
214. Guiard, J., Langpap, B., Kitov, P., Peters, P. and Bundle, D. R. “Double-Click” Protocol for
Synthesis of Heterobifunctional Multivalent Ligands: Toward a Focused Library of Specific
Norovirus Inhibitors. Chem. Eur. J., 17, 7438-7441, 2011.
215. Rademacher, C., Guiard, J., Kitov, P., Langpap, B., Dalton, K. P., Parra, F., Bundle, D. R. and
Peters, P. Targeting Norovirus Infection – Multivalent Entry Inhibitor based on NMR Data.
Chem. Eur. J., 17, 7442-7453, 2011.
216. Cui, L., Kitov, P. I., Completo, G. C., Paulson, J. C. and Bundle. D. R. Supramolecular
Complexing of Membane Siglec CD22 Mediated by a Polyvalent Heterobifunctional Ligand that
Templates on IgM. Bioconjug. Chem., 22, 546-550, 2011.
217. Lipinski, T., Luu, T., Kitov, P. I., Szpacenko, A. and Bundle, D. R. A structurally diversified
linker enhances the immune response to a small carbohydrate hapten. Glycoconj. J., 28, 149-164,
2011.
218. Sandbhor, M. S., Soya, N, Albohy, A., Zheng, R. B., Cartmell, J., Bundle, D. R., Klassen, J. S.
and Cairo, C. W. Substrate recognition of the membrane-associated sialidase NEU3 requires a
hydrophobic aglycone. Biochemistry, 50, 6753-5762, 2011.
219. Kitov, P. I., Paszkiewicz, E., Sadowska, J.M., Deng, Z., Ahmed, M., Narain, R., Griener, T.,
Mulvey, G. L., Armstrong, G. D., Bundle, D. R. Impact of the nature and size of the polymeric
backbone on the ability of heterobifunctional ligands to mediate Shiga toxin and serum amyloid
P component ternary complex formation. Toxins, 3, 1065-1088, 2011.
220. Zhang, P., Razi, N., Eugenio, L., Fentabil, M., Kitova, E.N., Klassen, J.S., Bundle, D.R., Ng,
K.K.-S. and Ling, C.-C. Unexpected structure of a Clostridium difficile toxin A ligand
necessitates an annotation correction in a popular screening library. Chem. Comm. 47, 12397-
12399, 2011.
221. Costello, C. and Bundle, D. R. Synthesis of three trisaccharide congeners to investigate frame
shifting of β1,2-mannan homo-oligomers in an antibody binding site. Carbohydr. Res., March
2012 in press. http://dx.doi.org/10.1016/j.carres.2012.03.019,
222. Xin, H., Cartmell, J., Bailey, J. J., Dziadek, S., Bundle, D. R. and Cutler, J. E. Self -adjuvanting
Glycopeptide Conjugate Vaccine against Disseminated Candidiasis. PLoS One 7, e35106, 2012.
223. Johnson, M. A., Cartmell, J., Weisser, N. E., Woods, R. J., Bundle, D. R. Molecular recognition
of Candida albicans (1→2)-β-mannan oligosaccharides by a protective monoclonal antibody
reveals the immunodominance of internal saccharide residue. J. Biol. Chem.
doi:10.1074/jbc.M112.355578