percutaneous repair or surgery for mitral regurgitation everest ii objective:to compare the efficacy...

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Percutaneous Repair or Surgery for Mitral Regurgitation EVEREST II Objective: to compare the efficacy of percutaneous implantation of a clip and conventional surgery for repair or replacement of the mitral valve Study: multicenter randomized controlled trial (2:1 ratio) Population: patients with grade 3+ or 4+ mitral regurgitation Endpoint: efficacy: freedom from death, surgery for mitral dysf. at 12 months safety: composite of MACE within 30 days

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Page 1: Percutaneous Repair or Surgery for Mitral Regurgitation EVEREST II Objective:to compare the efficacy of percutaneous implantation of a clip and conventional

Percutaneous Repair or Surgery for Mitral Regurgitation EVEREST II

Objective: to compare the efficacy of percutaneous implantation of a clip and conventional surgery for repair or replacement of the mitral valveStudy: multicenter randomized controlled trial (2:1 ratio)Population: patients with grade 3+ or 4+ mitral regurgitation

Endpoint: efficacy: freedom from death, surgery for mitral dysf. at 12 months safety: composite of MACE within 30 days

Page 2: Percutaneous Repair or Surgery for Mitral Regurgitation EVEREST II Objective:to compare the efficacy of percutaneous implantation of a clip and conventional

Percutaneous Repair or Surgery for Mitral Regurgitation EVEREST II

Page 3: Percutaneous Repair or Surgery for Mitral Regurgitation EVEREST II Objective:to compare the efficacy of percutaneous implantation of a clip and conventional

Percutaneous Repair or Surgery for Mitral Regurgitation EVEREST II

Page 4: Percutaneous Repair or Surgery for Mitral Regurgitation EVEREST II Objective:to compare the efficacy of percutaneous implantation of a clip and conventional

Percutaneous Repair or Surgery for Mitral Regurgitation EVEREST II

Conclusion

percutaneous repair is less effective than surgery for need of surgery for mitral dysfunction, but the safety was superior

Feldman NEJM 2011;364:1395-406

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