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Personalized medicine Bioinformatics, fall 2016 Sulev Reisberg 20 October 2016

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Page 1: Personalized medicine Sulev Reisberg - ut · and developing relevant tools for personalized medicine @ Topics 1. Definition of personalized medicine 2. Main focus areas 3. ... vähene

Personalized medicine

Bioinformatics, fall 2016

Sulev Reisberg

20 October 2016

Page 2: Personalized medicine Sulev Reisberg - ut · and developing relevant tools for personalized medicine @ Topics 1. Definition of personalized medicine 2. Main focus areas 3. ... vähene

Software Analyst@

Data analyst and Project Manager

Data custodian

@ Representing of

About myself

Making big health data analytics (on Estonian central e-health database, insurance fund database, ...) and developing relevant tools for personalized medicine

@

Page 3: Personalized medicine Sulev Reisberg - ut · and developing relevant tools for personalized medicine @ Topics 1. Definition of personalized medicine 2. Main focus areas 3. ... vähene

Topics

1. Definition of personalized medicine 2. Main focus areas 3. Personalized medicine in Estonia

& what we do at STACC 4. Main challenges 5. Homework

Page 4: Personalized medicine Sulev Reisberg - ut · and developing relevant tools for personalized medicine @ Topics 1. Definition of personalized medicine 2. Main focus areas 3. ... vähene

What do you think,what is a personalized medicine?

Page 5: Personalized medicine Sulev Reisberg - ut · and developing relevant tools for personalized medicine @ Topics 1. Definition of personalized medicine 2. Main focus areas 3. ... vähene

What do you think,what is a personalized medicine?

Precision medicine P4 Medicine:

Personalized, Predictive,

Preventive, Participatory

Stratified medicine Targeted therapy

Page 6: Personalized medicine Sulev Reisberg - ut · and developing relevant tools for personalized medicine @ Topics 1. Definition of personalized medicine 2. Main focus areas 3. ... vähene

Personalised medicine refers to prevention, diagnosis and treatment of health disorders, based

on individual risk-tailored approach using computational decision support analysis of

person’s phenotype and genotype data.

The goal of personalised medicine is to contribute towards preventive, predictive and participatory

health system.

Definition in Estonia

Source: Ministry of Social Affairs, 2015

Genetic data must be involved

Applies also to healthy people

Computers must be involved

The main goal is to prevent getting ill. We deal with the problems where the prevention is possible and proven. It is called “actionable”

Some sort of recommendations are made

The patient’s role has to grow

Page 7: Personalized medicine Sulev Reisberg - ut · and developing relevant tools for personalized medicine @ Topics 1. Definition of personalized medicine 2. Main focus areas 3. ... vähene

Key drivers (prerequisites) for personalized medicine

● Drop of DNA sequencing cost ● Increase of computational power ● Rise of big data analytics ● Electronic health records (EHR) ● Huge cost and high failure rate of clinical trials ● Devices for ‘quantified-self’ (wearables) ● Population ageing, increase of healthcare costs ● ...

Page 8: Personalized medicine Sulev Reisberg - ut · and developing relevant tools for personalized medicine @ Topics 1. Definition of personalized medicine 2. Main focus areas 3. ... vähene

Source: https://www.gov.uk/government/news/human-genome-uk-to-become-world-number-1-in-dna-testing

“The UK is set to becomethe world leader in ground-breaking genetic researchinto cancer and rare diseases, which will transform how diseases are diagnosed and treated, thanks toa package of investment worth more than £300 million, the Prime Minister will announce today.”

David Cameron,Prime Minister of UK

1 Aug 2014

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Barack Obama,the President of United States, launching “Precision Medicine”

initiative

Jan 2015

“I want the country that eliminated polioand mapped the human genometo lead a new era of medicine – one that deliversthe right treatment at the right time.”

Source: http://www.reuters.com/article/us-usa-obama-genomics-idUSKBN0KU06L20150121

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Jevgeni Ossinovski,Minister of Health and

Labour of the Republic of Estonia

Oct 2015

“Estonia has a unique opportunityto be among the leaders of the developersand practitioners of the personalized medicine solutions.”

Source: http://sm.ee/et/uudised/personaalmeditsiin-terviseinnovatsiooni-voimalus-eesti-jaoks (free translation)

Page 11: Personalized medicine Sulev Reisberg - ut · and developing relevant tools for personalized medicine @ Topics 1. Definition of personalized medicine 2. Main focus areas 3. ... vähene

Main focus areas

Page 12: Personalized medicine Sulev Reisberg - ut · and developing relevant tools for personalized medicine @ Topics 1. Definition of personalized medicine 2. Main focus areas 3. ... vähene

Focus area 1:

Pharmacogenomics (PGx)

Page 13: Personalized medicine Sulev Reisberg - ut · and developing relevant tools for personalized medicine @ Topics 1. Definition of personalized medicine 2. Main focus areas 3. ... vähene

Picture source: Brian B. Spear, Margo Heath-Chiozzi, Jeffrey Huff, “Clinical Trends in Molecular Medicine, Volume 7, Issue 5, 1 May 2001, Pages 201-204

The main driver for pharmacogenomics

Percentage ofthe patient population

for which a particular drug is ineffective (in 2001)

Page 14: Personalized medicine Sulev Reisberg - ut · and developing relevant tools for personalized medicine @ Topics 1. Definition of personalized medicine 2. Main focus areas 3. ... vähene

means abnormal cell growth regulation

Cancer

Cancer treatment

killing cells that divide rapidlyand/or block the cell growth.

Targeted chemotherapy

how to make the drug to distinguish such cells from the others

The main problem The selected therapy is usually based onthe nature of the particular cancer cell

(has somatic mutations, its DNA is different from patient’s healthy DNA etc.)

Page 15: Personalized medicine Sulev Reisberg - ut · and developing relevant tools for personalized medicine @ Topics 1. Definition of personalized medicine 2. Main focus areas 3. ... vähene

Pharmagogenomics - choosing right medication (1)

Used to treat breast cancerif the cancer cell is growing because of the estrogen hormone (it has estrogen receptors) (70%)This drug blocks hormone receptors of the cell,

preventing hormones from binding to them.

Approved already in 1972

Page 16: Personalized medicine Sulev Reisberg - ut · and developing relevant tools for personalized medicine @ Topics 1. Definition of personalized medicine 2. Main focus areas 3. ... vähene

Pharmagogenomics - choosing right medication (2)

Used to treat breast cancerif the cancer cell is overexpressing HER2 protein (20%)

Herceptin binds to HER2 receptors and blocks them from receiving growth signals.

More of a protein HER2 (human epidermal growth factor receptor) causes these cells to grow and spread faster than the ones with normal levels of the protein.

Page 17: Personalized medicine Sulev Reisberg - ut · and developing relevant tools for personalized medicine @ Topics 1. Definition of personalized medicine 2. Main focus areas 3. ... vähene

Personalized drug selection/dosage

The right drug and right dosage are selected based on the patient’s genome

Goal: to avoid taking drug that is

not working on that patient orcauses adverse side effects

Page 18: Personalized medicine Sulev Reisberg - ut · and developing relevant tools for personalized medicine @ Topics 1. Definition of personalized medicine 2. Main focus areas 3. ... vähene

Side-effect:causes life-threatening hypersensitivity reaction

for patients havingany *57:01 variants

in immune system gene HLA-B

Used to treat HIV

Pharmagogenomics - avoid adverse drug effects

Page 19: Personalized medicine Sulev Reisberg - ut · and developing relevant tools for personalized medicine @ Topics 1. Definition of personalized medicine 2. Main focus areas 3. ... vähene

Warfarin:Reduces blood clots and therebyreduces the risk of heart attack

Pharmagogenomics - adjust the dosage

The right dosing depends on several genetic variants(CYP2C9, VKORC1):

break it down too quickly and it will not have the desired effect;too slowly, and the risk of bleeding increases.

Page 20: Personalized medicine Sulev Reisberg - ut · and developing relevant tools for personalized medicine @ Topics 1. Definition of personalized medicine 2. Main focus areas 3. ... vähene

Focus area 2:

Genetic testingrelated to having a baby

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Having a baby

A couple wants to have a baby

Birth of the child

Pregnancy

a) Carriertesting

b) Pre-natal diagnostics

c) Early post-natal testing if there are

complications

Genetic testing:

Page 22: Personalized medicine Sulev Reisberg - ut · and developing relevant tools for personalized medicine @ Topics 1. Definition of personalized medicine 2. Main focus areas 3. ... vähene

to test, whetheryou and your partner both havethe same recessive abnormal gene (that means: no symptoms)that may result in affected child.

a) Carrier screening/testingGoal:

Typically tested diseases:Cystic Fibrosis, Sickle Cell Disease, Neurodevelopmental disorders and other Mendelian (one-gene) diseases

Usually done in case there has been the disease in the family tree.

Page 23: Personalized medicine Sulev Reisberg - ut · and developing relevant tools for personalized medicine @ Topics 1. Definition of personalized medicine 2. Main focus areas 3. ... vähene

To detect genetic problemsof the babybefore birth.

b) Pre-natal testing

Goal:

Typically screening for the most common chromosomal disorders: Down syndrome (21th chr), Edwards syndrome (18), Patau syndrome (13), also for rhesus factor conflict

Picture taken from http://www.globalwomenconnected.com/2016/07/non-invasive-prenatal-testing-offered-pregnant-women/

Page 24: Personalized medicine Sulev Reisberg - ut · and developing relevant tools for personalized medicine @ Topics 1. Definition of personalized medicine 2. Main focus areas 3. ... vähene

To detect, whether the complications are caused by the genetic disorder (and particularly which disorder)

c) Post-natal genetic testing if there are complications

Goal:

● Used, if genetic disorder is suspected. ● In case the particular genetic disorder is found (not often), then:

○ carrier screening is performed for the parents usually to detect who is the carrier. ■ Often (ca ⅔ cases) none of them is the carrier. Meaning that the gene mutation

was occurred randomly only on the baby (called de novo mutation).

Page 25: Personalized medicine Sulev Reisberg - ut · and developing relevant tools for personalized medicine @ Topics 1. Definition of personalized medicine 2. Main focus areas 3. ... vähene

Focus area 3:

Prevention and early diagnosis

Page 26: Personalized medicine Sulev Reisberg - ut · and developing relevant tools for personalized medicine @ Topics 1. Definition of personalized medicine 2. Main focus areas 3. ... vähene

Cancer screening

● There are lots of gene mutations that are associated with high risk of cancer: ○ Most widely known: ■ some specific mutations in BRCA1 or BRCA2

genes lead to 55-65% risk of developing breast cancer

Page 27: Personalized medicine Sulev Reisberg - ut · and developing relevant tools for personalized medicine @ Topics 1. Definition of personalized medicine 2. Main focus areas 3. ... vähene

Risks for complex diseases

● Based on risks scores that are calculated on number of different genetic markers. ○ E.g risk score for Type 2 Diabetes based on 1000

markers ○ Often combined with other parameters,

e.g body-mass index (BMI)

Page 28: Personalized medicine Sulev Reisberg - ut · and developing relevant tools for personalized medicine @ Topics 1. Definition of personalized medicine 2. Main focus areas 3. ... vähene

Focus area 4:

Clinical decision support systems(CDSS)

Page 29: Personalized medicine Sulev Reisberg - ut · and developing relevant tools for personalized medicine @ Topics 1. Definition of personalized medicine 2. Main focus areas 3. ... vähene

Current trends of CDSS

Shared knowledge-base, accessible via web-services.From rule-based knowledge-base towards machine-learning based knowledge

Ensuring data interoperability: data standards…

Genetic information

added, “quantified-self” data added

Integrating alerts seamlessly into workflowImage: El-Sappagh, Shaker H., and Samir El-Masri. "A distributed clinical decision support system architecture." Journal of King Saud University-Computer and Information Sciences 26.1 (2014): 69-78.

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Personalized medicinein Estonia

Page 31: Personalized medicine Sulev Reisberg - ut · and developing relevant tools for personalized medicine @ Topics 1. Definition of personalized medicine 2. Main focus areas 3. ... vähene

Personalized medicine in Estonia

Estonian Genome Center ● Biobank,

○ holding biosamples of 5% of Estonian population ■ Including 2300 full DNA sequences

and more ○ + rich health information (continuously

updated) for all participants ● Researchers ● Together with Tartu University Hospital

carried out carrier screening, pre- and post-natal testing (by now these analyses have moved to separate institution Geneetikakeskus)

Page 32: Personalized medicine Sulev Reisberg - ut · and developing relevant tools for personalized medicine @ Topics 1. Definition of personalized medicine 2. Main focus areas 3. ... vähene

Personalized medicine in Estonia

Bioinformatics, Algorithmics and Data Mining Group

Bioinformatics research(incl multi-omics research)

Data mining of Electronic Medical Records,Wearables (quantified-self), Decision support systems

Page 33: Personalized medicine Sulev Reisberg - ut · and developing relevant tools for personalized medicine @ Topics 1. Definition of personalized medicine 2. Main focus areas 3. ... vähene

Personalized medicine in Estonia

+ collaborationwith medical

doctors

Page 34: Personalized medicine Sulev Reisberg - ut · and developing relevant tools for personalized medicine @ Topics 1. Definition of personalized medicine 2. Main focus areas 3. ... vähene

Bioinformatics @STACC Re-using the

analysis outcomes

Building database for effective analysis

Visualizations,decision support

systems

Data analysisOrganizing the medical data

Build analysis tools!@

STAC

C

Page 35: Personalized medicine Sulev Reisberg - ut · and developing relevant tools for personalized medicine @ Topics 1. Definition of personalized medicine 2. Main focus areas 3. ... vähene

Building a database

Medical records

Insurance bills

Data from wearables

Parsing, fact extraction,harmonization,

aggregation

Beautiful database

Page 36: Personalized medicine Sulev Reisberg - ut · and developing relevant tools for personalized medicine @ Topics 1. Definition of personalized medicine 2. Main focus areas 3. ... vähene

Typical EHR document in Estonia

(HL7v3)

Page 37: Personalized medicine Sulev Reisberg - ut · and developing relevant tools for personalized medicine @ Topics 1. Definition of personalized medicine 2. Main focus areas 3. ... vähene

Typical EHR document in Estonia

(HL7v3)

14 such documents

for every Estonian(on average)

Page 38: Personalized medicine Sulev Reisberg - ut · and developing relevant tools for personalized medicine @ Topics 1. Definition of personalized medicine 2. Main focus areas 3. ... vähene

Tarkvara TAK (STACC)

HL7v3 XML example 1...

...

DGN=It is a diagnosis

Diagnosis code (ICD-10)

Statistical type (it is a subsequent diagnosis)

It is the main diagnosis

Textual diagnosis

Page 39: Personalized medicine Sulev Reisberg - ut · and developing relevant tools for personalized medicine @ Topics 1. Definition of personalized medicine 2. Main focus areas 3. ... vähene

Tarkvara TAK (STACC)

HL7v3 XML example 2...

...

Complaints, observations in free text parts

Pulse measurements in free text parts

...

Blood pressure measurements in free text parts

Page 40: Personalized medicine Sulev Reisberg - ut · and developing relevant tools for personalized medicine @ Topics 1. Definition of personalized medicine 2. Main focus areas 3. ... vähene

Tarkvara TAK (STACC)

HL7v3 XML example 3...

Height, weight and BMI in free text, with error (swapped values)...

Page 41: Personalized medicine Sulev Reisberg - ut · and developing relevant tools for personalized medicine @ Topics 1. Definition of personalized medicine 2. Main focus areas 3. ... vähene

Anonymization tool

Anonymized text:

Patsient XXX Vanus 44 a. IK – XXX võeti statsionaarsele ravile.

Asjaolude täpsustamiseks helistada dr. XXX tel: XXX, kell 10.00-13.00.

Anonymizationtool

Based on statistical language models

Input text:

Patsient John Doe Vanus 44 a. IK – 77771478888 võeti statsionaarsele ravile.

Asjaolude täpsustamiseks helistada dr. Hämarikule tel: 7177765, kell 10.00-13.00.

Page 42: Personalized medicine Sulev Reisberg - ut · and developing relevant tools for personalized medicine @ Topics 1. Definition of personalized medicine 2. Main focus areas 3. ... vähene

• Siinusrütm 59 lööki min

• Kiirenenud, Ekg-l siinus rütm , 160/min

• vatsakeste tahhüarütmia fr - ga 150 lööki min

• EKG --> siinusrütm, fr.110xmin

• Ps 66/min

• Fr = 77 ' min

• Maksimaalne fr=196 , minimaalne fr=55

• V/v-l RR 133/105/90 , arütmia

Original data Extracted data

Fact extraction

59

160

150

110

66

77

196; 55

90

Page 43: Personalized medicine Sulev Reisberg - ut · and developing relevant tools for personalized medicine @ Topics 1. Definition of personalized medicine 2. Main focus areas 3. ... vähene

Context Actual meaning… p silm ei näe …

… kolmas p palavik …

… vähene p pleurareaktsiooni riba …… p 6mm ümmargune …

parem

päevparietaalne

pupill

Detecting the meaning of abbreviation

Full form

Parietaalne Parem

Päev Pupill

Probability

92% 4% 3% 0.3%

Page 44: Personalized medicine Sulev Reisberg - ut · and developing relevant tools for personalized medicine @ Topics 1. Definition of personalized medicine 2. Main focus areas 3. ... vähene

This helps you to find more documents:

3

TEXTA - for finding contextually similar documentsSystem provides contextually similar words:ibuprofen ibuprofeni paracetamol paracetamool ibumetin paracetamo paratsetamol... 2

Enterseed words:

paratsetamool ibuprofeen

1

Page 45: Personalized medicine Sulev Reisberg - ut · and developing relevant tools for personalized medicine @ Topics 1. Definition of personalized medicine 2. Main focus areas 3. ... vähene

Getting an overview of the whole database

Budget of Estonian Health Insurance Fund

CardiologyBudget: 11MSpent: 13M (115%)

Page 46: Personalized medicine Sulev Reisberg - ut · and developing relevant tools for personalized medicine @ Topics 1. Definition of personalized medicine 2. Main focus areas 3. ... vähene

60%

0% 27%

13%Lääne-Virumaa

Where the people from Lääne-Virumaa are traveling toin order to get their cataract surgery

Patient trajectories

Pärnu Tartu

TallinnKohtla-Järve

Page 47: Personalized medicine Sulev Reisberg - ut · and developing relevant tools for personalized medicine @ Topics 1. Definition of personalized medicine 2. Main focus areas 3. ... vähene

Averageannual cost ofhealthcareservicesof eachEstonian citizen by age

Page 48: Personalized medicine Sulev Reisberg - ut · and developing relevant tools for personalized medicine @ Topics 1. Definition of personalized medicine 2. Main focus areas 3. ... vähene

Overview of the patient

(Blood pressure)

(Blood glucose) (Cholesterol)

(Diagnosis)

(Glucated hemoglobin)

Diabetes

Page 49: Personalized medicine Sulev Reisberg - ut · and developing relevant tools for personalized medicine @ Topics 1. Definition of personalized medicine 2. Main focus areas 3. ... vähene

Medical records Wearables

Genetic dataMedical insurance bills

Overview of the patient

Page 50: Personalized medicine Sulev Reisberg - ut · and developing relevant tools for personalized medicine @ Topics 1. Definition of personalized medicine 2. Main focus areas 3. ... vähene

Decision support system for family doctors

Page 51: Personalized medicine Sulev Reisberg - ut · and developing relevant tools for personalized medicine @ Topics 1. Definition of personalized medicine 2. Main focus areas 3. ... vähene

Quantified-self (wearables)

Page 52: Personalized medicine Sulev Reisberg - ut · and developing relevant tools for personalized medicine @ Topics 1. Definition of personalized medicine 2. Main focus areas 3. ... vähene

Raw data ofpupil footsteps in Estonian primary schools

Page 53: Personalized medicine Sulev Reisberg - ut · and developing relevant tools for personalized medicine @ Topics 1. Definition of personalized medicine 2. Main focus areas 3. ... vähene

Average number of footsteps made in different lessons in Estonian primary schools

Phys

ical t

rain

ing

Info

rmat

ics

Engl

ish

Esto

nian

Sing

ing

less

on

Page 54: Personalized medicine Sulev Reisberg - ut · and developing relevant tools for personalized medicine @ Topics 1. Definition of personalized medicine 2. Main focus areas 3. ... vähene

Main challenges

Page 55: Personalized medicine Sulev Reisberg - ut · and developing relevant tools for personalized medicine @ Topics 1. Definition of personalized medicine 2. Main focus areas 3. ... vähene

Challenge 1:Does personalized medicine

have any impact?

Page 56: Personalized medicine Sulev Reisberg - ut · and developing relevant tools for personalized medicine @ Topics 1. Definition of personalized medicine 2. Main focus areas 3. ... vähene

28% 72% of the solutions provide

non-significant or mixed impact for the patient.

of health IT solutions have proven some positive impact to the patients.

Brenner, Samantha K., et al. "Effects of health information technology on patient outcomes: a systematic review." Journal of the American Medical Informatics Association (2015): ocv138.

Page 57: Personalized medicine Sulev Reisberg - ut · and developing relevant tools for personalized medicine @ Topics 1. Definition of personalized medicine 2. Main focus areas 3. ... vähene

Benefit of using personalized strategy for cancer

One of the first of few studies thatshow thatusing personalized(biomarker-based) strategylead toimproved cancer patient outcomes(2015)

Schwaederle, Maria Clemence, et al. "Personalized therapy in diverse cancers: Meta-analysis of 32,149 patients in phase II clinical trials." ASCO

Annual Meeting Proceedings. Vol. 33. No. 15_suppl. 2015.

Page 58: Personalized medicine Sulev Reisberg - ut · and developing relevant tools for personalized medicine @ Topics 1. Definition of personalized medicine 2. Main focus areas 3. ... vähene

Targeted cancer treatment is the most promising field, but…

• Most of the “targeted” drugsonly block one of the tumor growing pathways

• Cancer cells almost alwaysdevelop a resistance to single-targeted drug

• Most of the drugsare too toxic to use in combination

Page 59: Personalized medicine Sulev Reisberg - ut · and developing relevant tools for personalized medicine @ Topics 1. Definition of personalized medicine 2. Main focus areas 3. ... vähene

Challenge 2:How to organize

the massive (and growing) amount of data and knowledge?

Genomic basis of the disease Influences of disorders of translation and expression

Behavior Environment

Page 60: Personalized medicine Sulev Reisberg - ut · and developing relevant tools for personalized medicine @ Topics 1. Definition of personalized medicine 2. Main focus areas 3. ... vähene

Take-home message

Page 61: Personalized medicine Sulev Reisberg - ut · and developing relevant tools for personalized medicine @ Topics 1. Definition of personalized medicine 2. Main focus areas 3. ... vähene

Take-home message

is more precise clinical approachby using patient’s genomics

(and also other data)

Personalized medicineTargeted cancer treatment

Pre- and post-natal diagnostics

Ready-to-use focus areas

Show that personalized approachhas a positive impact

Main challengeYes! We do!

In Estonia

Page 62: Personalized medicine Sulev Reisberg - ut · and developing relevant tools for personalized medicine @ Topics 1. Definition of personalized medicine 2. Main focus areas 3. ... vähene

Homework(2 tasks)

Page 63: Personalized medicine Sulev Reisberg - ut · and developing relevant tools for personalized medicine @ Topics 1. Definition of personalized medicine 2. Main focus areas 3. ... vähene

Task 1: analyzing schoolchildren activity

One schoolday, from 8 till 15 o’clockNB! Pupils are from different schools!

Given: footstep data of 4 primary school pupils: A, B, C, D (measured in Sep 2016)

Your task: analyse the data of 3 pupilsaccording to your matrice number

Page 64: Personalized medicine Sulev Reisberg - ut · and developing relevant tools for personalized medicine @ Topics 1. Definition of personalized medicine 2. Main focus areas 3. ... vähene

Task 1: download data

https://www.dropbox.com/s/ma6zwg2v3mlzqkw/pupildata.zip?dl=0 Contains four files:

Each looks like this:

Page 65: Personalized medicine Sulev Reisberg - ut · and developing relevant tools for personalized medicine @ Topics 1. Definition of personalized medicine 2. Main focus areas 3. ... vähene

Task 1: select pupils

Last number of your student ID

Pupils to analyze

0, 1 or 2 A, B, C

3 or 4 A, B, D

5 or 6 A, C, D

7, 8 or 9 B, C, DE.g B55569

Select pupils from this table according to the last number of your student ID:

Page 66: Personalized medicine Sulev Reisberg - ut · and developing relevant tools for personalized medicine @ Topics 1. Definition of personalized medicine 2. Main focus areas 3. ... vähene

Task 1: Data preparation (1)

a) Take the data of 3 pupils and save it to the same dataset.

b) Get some sort of heatmap of your data.You may use whatever tool you like for this. R is an option. Also

Excel with its “conditional formatting” feature works well.

NB! You do not need to report the heatmap in your homework.

Page 67: Personalized medicine Sulev Reisberg - ut · and developing relevant tools for personalized medicine @ Topics 1. Definition of personalized medicine 2. Main focus areas 3. ... vähene

Task 1: Data preparation (2)

c) All lessons last 45 minutes. Two pupils are from the same school and same class and the third one is from another school.

Having that knowledge, detect at what times each lesson begins and ends in both schools.

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Task 1: Answer to questions (1-5)

1. Which pupil has been the most active? Who is the least?

2. Which pupils are from the same class? Justify your answer.

3. In each school, there is a breakfast break where the food is provided. Can you find, which break is that in each school? How did you find it?

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Task 1: Answer to questions (1-5)4. One or two pupils in your data had the physical exercise lesson. Which one(s)? Justify your answer.

5. Imagine that you have 100x more pupils measured this way from different schools. What do you think, what are the difficulties of analysing such data?

Warning: this is a real-life data, it’s quite messy.There are no 100% correct answers in this task.

Page 70: Personalized medicine Sulev Reisberg - ut · and developing relevant tools for personalized medicine @ Topics 1. Definition of personalized medicine 2. Main focus areas 3. ... vähene

Task 2: analyzing healthcare bills

Given: 0.1% of all healthcare service billsin Estonia in 2015

Your task: analyse the data

Page 71: Personalized medicine Sulev Reisberg - ut · and developing relevant tools for personalized medicine @ Topics 1. Definition of personalized medicine 2. Main focus areas 3. ... vähene

Task 2: download datahttps://www.dropbox.com/s/jorfgtk2yqqfqto/healthcare_services_2015_sampling.csv?dl=0 Contains 0.1% of healthcare service bills in Estonia 2015.Looks like this:

Each row is one bill.

Each bill contains:* Diagnosis code (ICD-10 classification) * cost (euros)

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Task 1: Answer to questions (1-2)1. Find 3 bills with the the largest costs. What are the

corresponding diagnosis names? Use http://apps.who.int/classifications/icd10/browse/2016/en to find the names.

2. When summing the bills with the same codes together, what is the most expensive diagnosis code? What is the corresponding diagnosis name? How large amount of total costs it uses?

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Send homeworks to

[email protected] by 27th October 12:00 (1 week!)

(PDF please)!

Thank you!