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H.Pylori

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Classification:

Domain BacteriaPhylum proteobacteriaClass EpsilonproteobacteriaOrder CampylobacteralesFamily HelicobacteriaceaeGenus Helicobater

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Classification:Helicobacteraceae:Genera: Helicobacter, Wolinella, Flexispira,Sulfurimonas, Thiomicrospira, and Thiovulum

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Microbiology of H. pylori

- Genome- Morphology-Cell envelope, and LPS-Growth requirements- Metabolism

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CLINICAL ASPECTS OF H. PYLORI ASSOCIATED DISEASES• Acute and chronic gastritis -Acute gastritis -Chronic gastritis

• Peptic ulcer disease -Gastric ulcers -Duodenal ulcers

• Gastric MALT lymphoma• Atrophic gastritis, intestinal metaplasia,

gastric cancer 8

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Natural History of Helicobacter pylori Infection

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Role of H. pylori Virulence Factors

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cag A (“cytotoxin associated gene A”)

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VacA (vacuolating cytotoxin A)

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Pathogenesis of H.pylori

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Pathogenesis of H.pylori

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توجه از تشكر با27 شما