COURSE INFORMATON

Course Title Code Semester T+U Hour

Credits ECTS

PHARMACEUTICAL AND MEDICAL BIOTECHNOLOGY

BTEC 504

1-2 3 + 0 3 8

Prerequisites NONE

Language of Instruction

English

Course Level MSc and PhD Degrees

Course Type Elective

Course Coordinator Prof. Dr.Recep Serdar Alpan

Instructors Prof. Dr.Recep Serdar Alpan Prof. Dr. Ece Genç

Assistants NONE

Internship NONE

Goals

To understand theoretical background of the application of

biotechnology techniques and applications on therapeutic

products, gene therapy, gene application techniques, tissue

engineering, antibody engineering, monoclonal antibodies,

vaccines, sera and pharmaceutical applications.

Content

Introduction to Medical Biotechnology; Protein isolation and

expression technics in Medical Biotechnology; Biotechnology in

Pharmaceutical Production; Tissue Engineering; Monoclonal

antibodies and cellular targeted immunologic therapeutic

applications; Drug development with Recombinant DNA

Technology; Gene Therapy Applications in Medicine

siRNA, Micro-RNA Drugs; Recombinant Vaccines; Drugs that

reverse Drug Resistance

Course Learning Outcomes Program Learning

Teaching Methods

Assessment Methods

Outcomes

1) Understands theoretical background of the application of biotechnology techniques and applications on therapeutic products

2,4,9 1,2 A,C,D

2) Learns types of cells used in Tissue Engineering and Recombinant technology

2,3,4,7 1,2 A,C,D

3) Learns Gene Therapy and effect on

ethics 2,3,4,7 1,2 A,C,D

Teaching Methods: 1: Lecture, 2: Question-Answer, 3: Laboratory, 4: Case-study

Assessment Methods: A: Testing, B: Laboratory, C: Homework, D: Project

COURSE CONTENT

Week Topics Study Materials

1 Introduction to Medical Biotechnology Textbook and Current

Literature

2

Protein isolation and expression technics in Medical

Biotechnology

Textbook and Current

Literature

3

Biotechnology in Pharmaceutical Production Textbook and Current

Literature

4

Tissue Engineering Textbook and Current

Literature

5

Monoclonal antibodies and cellular targeted immunologic

therapeutic applications

Textbook and Current

Literature

6

Drug development with Recombinant DNA Technology I Textbook and Current

Literature

7

Drug development with Recombinant DNA Technology II Textbook and Current

Literature

8

Mid-term Textbook and Current

Literature

9

Gene Therapy Applications in Medicine I Textbook and Current

Literature

10

Gene Therapy Applications in Medicine I Textbook and Current

Literature

11

siRNA, Micro-RNA Drugs Textbook and Current

Literature

12

Recombinant Vaccines I Textbook and Current

Literature

13

Recombinant Vaccines II Textbook and Current

Literature

14

Drugs that reverse Drug Resistance Textbook and Current

Literature

RECOMMENDED SOURCES

Textbook Pongracz & Keen, Medical Biotechnology, Churchill Livingston, Elsevier

Additional Resources Current Literatures about Medical Biotechnolgy

MATERIAL SHARING

Documents Lecture notes are given to students

Assignments Project assignment sheet containing project subjects and directions about how to prepare presentation is given to students

Exams 1 Midterm, 1 Project Presentation and 1 Final

ASSESSMENT

IN-TERM STUDIES NUMBER PERCENTAGE

Mid-terms 1 50

Term Project 1 50

Total 100

CONTRIBUTION OF FINAL EXAMINATION TO OVERALL GRADE

40

CONTRIBUTION OF IN-TERM STUDIES TO OVERALL GRADE

60

Total 100

COURSE CATEGORY Field Courses

COURSE'S CONTRIBUTION TO PROGRAM

No Program Learning Outcomes

Contribution Level

1 2 3 4 5

1 Advanced level knowledge of mathematics, statistics, and bioengineering.

2 The ability of designing biological systems, analysis or process in order to meet up with the desired requirements/products.

X

3

The ability of identification and describing the engineering problems in biotechnology and bioengineering and proposing solution by making use of most up-to-date techniques and instruments.

X

4

The ability of working efficiently in interdisciplinary teams and being definitive in decision making process by taking responsibilities.

X

5

The ability of developing efficient communicating skills in the field of biotechnology and presenting oneself efficiently in social and scientific arena/platforms.

6

The ability to have occupational ethics and social responsibilities, intellectual conscious in areas of professional conversations, declarations, and applications.

7 The ability of perceiving occupational ethics and their implications on the society at legal and economic level.

X

8 The ability of retaining the necessity of lifelong education, learning, and improvement and gain the skills to achieve this.

9 The ability of perceiving the impact of bioengineering, genetics, and biotechnology products and solutions at the environmental, global and social levels.

X

10 The ability to express oneself in English orally and in writing at global platform.

ECTS ALLOCATED BASED ON STUDENT WORKLOAD BY THE COURSE DESCRIPTION

Activities Quantity Duration (Hour)

Total Workload

(Hour)

Course Duration (Excluding the exam weeks: 14x Total course hours)

14 3 42

Hours for off-the-classroom study (Pre-study, practice) 12 9 108

Mid-term examination 1 3 3

Laboratory - - -

Homework - - -

Project 1 30 30

Final examination 1 3 3

Total Work Load 186

Total Work Load / 25 (h) 7.44

ECTS Credit of the Course 8