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Pt: RAAGAS, NORWIN PHARMACOLOGICAL SHEET

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Drug name General action Specific action indication contraindication

Adverse effect Nursingresponsibility

1. Cefuroxime750mgIVTT q 8H

4. Metronidazole 500 gIVTT q 8H

-Antibiotic-Cephalosporins(secondgeneration)

-Antibiotic-Antibacterial-Amebicide-Antiprotozoal

-Bactericidal:inhibits synthesisof bacterial cellwall, causing celldeath.

-Bactericidal:Inhibits DNAsynthesis inspecificsanaerobes,causing cell

death;antiprotozoal-trichomonacidal,amebicidal:biochemicalmechanism ofaction in notknown.

-lowerrespiratoryinfections causedby S.pneumoniae, S.aureus, E.coli,Klebsiela, H.influenzae, S.pyrogenes.

-septicemiacaused by S.pneumoniae, S.aureus, E.coli,Klebsiela, H.influenzae.-Perioperativeprophylaxis.

-preoperative,intraoperative,postoperativeprophylaxis for

patientsundergoingcolorectalsurgery-Trichonomiasis-Acute intestinalamebiasis-prophylaxis for

-allergy tocephalosporinsor penicillins.-use cautiouslywith renal failure,lactation andpregnancy.

-hypersensitivitytometronidazole;pregnancy-use cautiouslywith CNSdisease, hepatic

disease,candidiasis,blood dyscrasias,lactation.

CNS: headache,dizziness,lethargy,paresthesiasGI: N&V, diarrhea,anorexia,abdominal pain,flatulence, livertoxicity

GU: nephrotoxicityHematologic:bone marrowdepressionLocal: pain,abscess atinjection site,phlebitis, inflationat IV site

CNS: headache,dizziness, alaxia,vertigo,

incoordination,insomnia,seizures, fatigueperipheralneuropathy.GI: unpleasantmetallic taste,anorexia, N&V,

-check for liverand renaldysfunction,lactation,pregnancy, andallergy tomedication-sensitivity tetsbefore and

during therapy ifexpectedresponse is notseen-have vitamin Kavailable in caseof hypopro-thrombinemiaoccurs-discontinue ifhypersensitivityreactions occur.

-teach pt toavoid alcoholwhile taking thisdrug, that the ptwill experiencethese sideeffects: stomachupset ordiarrhea.

-assess for CNSor hepaticdisease;candidiasis,blood dyscarias,pregnancy,lactation.-

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PT: DATIG, R PHARMACOLOGICAL SHEET

D G l ti S ifi ti I di ti t i di ti Ad ff t N i

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Drug name General action Specific action Indication contraindication Adverse effect Nursingresponsibility

1. Cefuroxime 750mgIVTT q 8H

2. Ranitidine50g IVTT q 8H

-Antibiotic-Cephalosporins(secondgeneration)

-Histamine2(H2)antagonist

-Bactericidal:inhibits synthesisof bacterial cellwall, causing celldeath.

-Competitivelyinhibits the

action ofhistamine at theH2 receptors ofthe parietal cellsof the stomach,inhibiting basalgastric acidsecretion and

astric acid

-lowerrespiratoryinfections causedby S.pneumoniae, S.aureus, E.coli,Klebsiela, H.influenzae, S.pyrogenes.

-septicemiacaused by S.pneumoniae, S.aureus, E.coli,Klebsiela, H.influenzae.-Perioperativeprophylaxis.

-short-termtreatment foractive duodenalulcer-short-termtreatment ofactive, benigngastric ulcer-treatment of

-allergy tocephalosporinsor penicillins.-use cautiouslywith renal failure,lactation andpregnancy

-allergy toranitidine,lactation-use cautiously

with impairedrenal or hepaticfunction,pregnancy.

CNS: headache,dizziness,lethargy,paresthesiasGI: N&V,diarrhea,anorexia,abdominal pain,flatulence, liver

toxicityGU:nephrotoxicityHematologic:bone marrowdepressionLocal: pain,abscess atinjection site,phlebitis,inflation at IV site

CNS : headache,malaise,dizziness,somnolence,insomnia, vertigoCV : tachycardia,

-check for liverand renaldysfunction,lactation,pregnancy, andallergy tomedication-sensitivity tetsbefore and

during therapy ifexpectedresponse is notseen-have vitamin Kavailable in caseof hypopro-thrombinemiaoccurs-discontinue ifhypersensitivityreactions occur.

-teach pt to avoidalcohol whiletaking this drug,that the pt willexperience theseside effects:stomach upset ordiarrhea.

-assess forallergy to drug,impaired real orhepatic function,lactation,