pharmacology
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pharmacology multiple choice questionTRANSCRIPT
PHARMACOLOGY YR ONE QUIZ
1. Weak bases are absorbed efficiently across the epithelial cells of the stomach. T/F
2. A small Vd indicates extensive binding to plasma proteins. T/F
3. Absorption of a weak-base drug is more likely to occur from the intestines than from the stomach. T/F
4. A basic drug is more ionized at PH 8 than PH2. T/F
5. Competitive antagonism cannot be reversed by increasing the amount of agonist present. T/F
6. A drug which is reabsorbed by the renal tubules is likely to have a longer half-life than one which is not reabsorbed by the renal tubules. T/F
7. What is the rate limiting step for a highly lipid soluble drug? F/T
8. Which route of administration is most likely to subject a drug to first pass effect?
9. Two drugs act on the same organ though independent receptors. This is _________ antagonism.
10. Define the following terms: - Half life - Therapeutic Window- Inverse agonist - Pharmacodynamics- Bioavailability - Competitive antagonist
(ANSWER ANY TWO OF THE FOLLOWING QUESTIONS 11-15) 5marks each
11. How does PH influence drug pharmacokinetics?
12. Drug plasma binding has the advantage of acting as drug reservoirs but it also has the disadvantage of drug-drug interaction that causes toxicity, explain
13. Explain with examples the clinical relevance on enzyme induction/inhibition.
14. Pharmacotherapy can fail for pharmacodynamic or pharmacokinetic reasons. Explain this statement.
15. Metabolism is a very important aspect in relation to drug therapeutic effect, duration drug action and drug elimination. Explain how metabolism affects the above three aspects.