pharmacology of general anesthetics dr. ashraf arafat, md dr. ashraf arafat, md assistant professor...
TRANSCRIPT
![Page 1: Pharmacology of general anesthetics Dr. Ashraf Arafat, MD Dr. Ashraf Arafat, MD Assistant Professor Department of Anesthesia, King Saud University 1](https://reader035.vdocuments.net/reader035/viewer/2022062300/56649e255503460f94b13ab7/html5/thumbnails/1.jpg)
Pharmacology of general anesthetics
Dr. Ashraf Arafat, MDDr. Ashraf Arafat, MDAssistant Professor Assistant Professor
Department of Anesthesia, King Saud University
11
![Page 2: Pharmacology of general anesthetics Dr. Ashraf Arafat, MD Dr. Ashraf Arafat, MD Assistant Professor Department of Anesthesia, King Saud University 1](https://reader035.vdocuments.net/reader035/viewer/2022062300/56649e255503460f94b13ab7/html5/thumbnails/2.jpg)
22
![Page 3: Pharmacology of general anesthetics Dr. Ashraf Arafat, MD Dr. Ashraf Arafat, MD Assistant Professor Department of Anesthesia, King Saud University 1](https://reader035.vdocuments.net/reader035/viewer/2022062300/56649e255503460f94b13ab7/html5/thumbnails/3.jpg)
Benzodiazepines (BZ)Benzodiazepines (BZ)
The 3 main drugs used in this category are diazepam, The 3 main drugs used in this category are diazepam, lorazepam and midazolam. lorazepam and midazolam.
Primary uses:Primary uses:
Anti-anxiety agent pre-op for premedication.Anti-anxiety agent pre-op for premedication.
SedationSedation
They are inadequate for use in surgical anesthesia “on They are inadequate for use in surgical anesthesia “on their own”, and must therefore be used with another their own”, and must therefore be used with another anesthetic agent (i.e. an inhalation anesthetic). anesthetic agent (i.e. an inhalation anesthetic).
33
![Page 4: Pharmacology of general anesthetics Dr. Ashraf Arafat, MD Dr. Ashraf Arafat, MD Assistant Professor Department of Anesthesia, King Saud University 1](https://reader035.vdocuments.net/reader035/viewer/2022062300/56649e255503460f94b13ab7/html5/thumbnails/4.jpg)
Advantages:Advantages:Relatively rapid onsetRelatively rapid onset
Cause amnesiaCause amnesia
Relatively little cardiovascular effectRelatively little cardiovascular effect
Anti-convulsantAnti-convulsant
Disadvantages:Disadvantages:Not analgesicNot analgesic
Cause respiratory depressionCause respiratory depression
Long-acting (diazepam or repeated inj. of midazolam)Long-acting (diazepam or repeated inj. of midazolam)
44
![Page 5: Pharmacology of general anesthetics Dr. Ashraf Arafat, MD Dr. Ashraf Arafat, MD Assistant Professor Department of Anesthesia, King Saud University 1](https://reader035.vdocuments.net/reader035/viewer/2022062300/56649e255503460f94b13ab7/html5/thumbnails/5.jpg)
a. diazepam (Valium)a. diazepam (Valium)It is water-insoluble, so IV use requires a non-It is water-insoluble, so IV use requires a non-aqueous vehicle which can cause local irritation/pain aqueous vehicle which can cause local irritation/pain
b. midazolam (Dormicum)b. midazolam (Dormicum)- water soluble, so drug of choice for IV administration - water soluble, so drug of choice for IV administration -It has a more rapid onset and more rapid elimination It has a more rapid onset and more rapid elimination than the other BZ’s. than the other BZ’s. -The most potent amnestic The most potent amnestic
c. lorazepam (Ativan)c. lorazepam (Ativan)water-insoluble, water-insoluble, less potent amnestic than less potent amnestic than midazolam, but a more potent amnestic than midazolam, but a more potent amnestic than diazepam. diazepam.
55
![Page 6: Pharmacology of general anesthetics Dr. Ashraf Arafat, MD Dr. Ashraf Arafat, MD Assistant Professor Department of Anesthesia, King Saud University 1](https://reader035.vdocuments.net/reader035/viewer/2022062300/56649e255503460f94b13ab7/html5/thumbnails/6.jpg)
BarbituratesBarbiturates
The 3 main drugs used in this category are The 3 main drugs used in this category are thiopental, thiamylal, and methohexital. thiopental, thiamylal, and methohexital.
Primary Use: Primary Use: Induction of anesthesiaInduction of anesthesia
Advantages: Advantages:
Rapid onset (10 - 30 sec)Rapid onset (10 - 30 sec)
Short duration (5 – 8 min) initial dose; redistributed Short duration (5 – 8 min) initial dose; redistributed from brain to muscle; prolonged on repeated from brain to muscle; prolonged on repeated injectioninjection
66
![Page 7: Pharmacology of general anesthetics Dr. Ashraf Arafat, MD Dr. Ashraf Arafat, MD Assistant Professor Department of Anesthesia, King Saud University 1](https://reader035.vdocuments.net/reader035/viewer/2022062300/56649e255503460f94b13ab7/html5/thumbnails/7.jpg)
Disadvantages:Disadvantages:Not analgesicNot analgesic
Decrease blood pressureDecrease blood pressure
Decrease respiratory rate and tidal volume or Decrease respiratory rate and tidal volume or apnea.apnea.
Coughing, laryngospasm, bronchospasm.Coughing, laryngospasm, bronchospasm.
77
![Page 8: Pharmacology of general anesthetics Dr. Ashraf Arafat, MD Dr. Ashraf Arafat, MD Assistant Professor Department of Anesthesia, King Saud University 1](https://reader035.vdocuments.net/reader035/viewer/2022062300/56649e255503460f94b13ab7/html5/thumbnails/8.jpg)
OpioidsOpioidsOpioids produce moderate sedation and profound Opioids produce moderate sedation and profound analgesia. They exert their effects by binding with analgesia. They exert their effects by binding with opioid receptors in CNS ( 3 major opioid receptors opioid receptors in CNS ( 3 major opioid receptors μ μ (mu), (mu), κκ (kappa), and (kappa), and δδ (delta). (delta).
The opioids most commonly used are The opioids most commonly used are
fentanyl fentanyl
sufentanil citrate (Sufenta)sufentanil citrate (Sufenta)
alfentanil (Alfenta)alfentanil (Alfenta)
remifentanil (Ultiva)remifentanil (Ultiva)
88
![Page 9: Pharmacology of general anesthetics Dr. Ashraf Arafat, MD Dr. Ashraf Arafat, MD Assistant Professor Department of Anesthesia, King Saud University 1](https://reader035.vdocuments.net/reader035/viewer/2022062300/56649e255503460f94b13ab7/html5/thumbnails/9.jpg)
Primary uses:Primary uses:
Analgesia Analgesia
Advantages:Advantages:
Profound analgesiaProfound analgesia
Relative cardiovascular stabilityRelative cardiovascular stability
High potency, short duration (15-30 min.; High potency, short duration (15-30 min.; Remifentanil; 5 min) except morphineRemifentanil; 5 min) except morphine
Reduces emergence phenomenaReduces emergence phenomena
Reversible by opioid receptor antagonistsReversible by opioid receptor antagonists
Disadvantages:Disadvantages:
NauseaNausea
Slow gastric emptyingSlow gastric emptying
Respiratory depression at high doses (assisted Respiratory depression at high doses (assisted ventilation required).ventilation required).
99
![Page 10: Pharmacology of general anesthetics Dr. Ashraf Arafat, MD Dr. Ashraf Arafat, MD Assistant Professor Department of Anesthesia, King Saud University 1](https://reader035.vdocuments.net/reader035/viewer/2022062300/56649e255503460f94b13ab7/html5/thumbnails/10.jpg)
FentanylFentanyl
A potent synthetic opioid agonist with between 50-100 A potent synthetic opioid agonist with between 50-100 times the analgesic potency of morphine. times the analgesic potency of morphine.
Used to aid induction and maintenance of general Used to aid induction and maintenance of general anesthesia and to supplement regional and spinal anesthesia and to supplement regional and spinal anesthesia. anesthesia.
Ability to maintain cardiac stability. Ability to maintain cardiac stability.
Sufentanil citrate (Sufenta)Sufentanil citrate (Sufenta)Rapid induction of analgesia (similar to Fentanyl)Rapid induction of analgesia (similar to Fentanyl)Compared to fentanyl and sufentanil, alfentanil has a Compared to fentanyl and sufentanil, alfentanil has a shorter duration of action because its high protein shorter duration of action because its high protein binding and relatively low lipid solubility .binding and relatively low lipid solubility .
1010
![Page 11: Pharmacology of general anesthetics Dr. Ashraf Arafat, MD Dr. Ashraf Arafat, MD Assistant Professor Department of Anesthesia, King Saud University 1](https://reader035.vdocuments.net/reader035/viewer/2022062300/56649e255503460f94b13ab7/html5/thumbnails/11.jpg)
Remifentanil (Ultiva)Remifentanil (Ultiva)
Ultra short acting and rapidly cleared because it’s Ultra short acting and rapidly cleared because it’s ester linkages are susceptible to hydrolysis by ester linkages are susceptible to hydrolysis by esterases in tissues and RBC’s. esterases in tissues and RBC’s.
MorphineMorphine
May produce hypotension and bronchoconstriction May produce hypotension and bronchoconstriction as a consequence of its histamine-releasing as a consequence of its histamine-releasing action.action.
1111
![Page 12: Pharmacology of general anesthetics Dr. Ashraf Arafat, MD Dr. Ashraf Arafat, MD Assistant Professor Department of Anesthesia, King Saud University 1](https://reader035.vdocuments.net/reader035/viewer/2022062300/56649e255503460f94b13ab7/html5/thumbnails/12.jpg)
KetamineKetamineA complete i.v. anesthetic -causes “dissociative A complete i.v. anesthetic -causes “dissociative anesthesia”anesthesia”
Primary uses:Primary uses:Induction or anesthesia in at risk patients w/ Induction or anesthesia in at risk patients w/ cardiovascular problemscardiovascular problems
Sedation or general anesthesia in childrenSedation or general anesthesia in children
Advantages:Advantages:
Cardiovascular stimulantCardiovascular stimulant
BronchodilatorBronchodilator
Profound analgesia and amnesiaProfound analgesia and amnesia1212
![Page 13: Pharmacology of general anesthetics Dr. Ashraf Arafat, MD Dr. Ashraf Arafat, MD Assistant Professor Department of Anesthesia, King Saud University 1](https://reader035.vdocuments.net/reader035/viewer/2022062300/56649e255503460f94b13ab7/html5/thumbnails/13.jpg)
Disadvantages:Disadvantages:
Emergence reactions (not in children <15; Emergence reactions (not in children <15; adults >65)adults >65)
Increases intracranial pressureIncreases intracranial pressure
Suppresses respiration (less severe than Suppresses respiration (less severe than other anesthetics)other anesthetics)
1313
![Page 14: Pharmacology of general anesthetics Dr. Ashraf Arafat, MD Dr. Ashraf Arafat, MD Assistant Professor Department of Anesthesia, King Saud University 1](https://reader035.vdocuments.net/reader035/viewer/2022062300/56649e255503460f94b13ab7/html5/thumbnails/14.jpg)
Propofol (Diprivan)Propofol (Diprivan)
Primary uses:Primary uses:
A sedative/hypnotic A sedative/hypnotic
Induction or maintenance of general anesthesia. Induction or maintenance of general anesthesia.
Sedating intubated, mechanically ventilated Sedating intubated, mechanically ventilated patients. patients.
Advantages: Advantages:
Rapid induction and recovery times even after Rapid induction and recovery times even after repeated injectionsrepeated injections
Anti-emetic propertiesAnti-emetic properties
1414
![Page 15: Pharmacology of general anesthetics Dr. Ashraf Arafat, MD Dr. Ashraf Arafat, MD Assistant Professor Department of Anesthesia, King Saud University 1](https://reader035.vdocuments.net/reader035/viewer/2022062300/56649e255503460f94b13ab7/html5/thumbnails/15.jpg)
Disadvantages:Disadvantages:
Pain on injectionPain on injection
Involuntary muscular movementInvoluntary muscular movement
Respiratory depression ,apnea Respiratory depression ,apnea
bradycardia and hypotension. bradycardia and hypotension.
1515
![Page 16: Pharmacology of general anesthetics Dr. Ashraf Arafat, MD Dr. Ashraf Arafat, MD Assistant Professor Department of Anesthesia, King Saud University 1](https://reader035.vdocuments.net/reader035/viewer/2022062300/56649e255503460f94b13ab7/html5/thumbnails/16.jpg)
EtomidateEtomidatePrimary use: Primary use: Induction in patients w/ cardiovascular problemsInduction in patients w/ cardiovascular problems
Advantages:Advantages:Rapid inductionRapid induction
Ultra-short acting (5 min)Ultra-short acting (5 min)
No cardiovascular depressionNo cardiovascular depression
Minimal respiratory depressionMinimal respiratory depression
Disadvantages:Disadvantages:
Pain on injectionPain on injection
Involuntary muscular movementInvoluntary muscular movement
Nausea and vomitingNausea and vomiting
HiccupsHiccups
Not analgesicNot analgesic1616
![Page 17: Pharmacology of general anesthetics Dr. Ashraf Arafat, MD Dr. Ashraf Arafat, MD Assistant Professor Department of Anesthesia, King Saud University 1](https://reader035.vdocuments.net/reader035/viewer/2022062300/56649e255503460f94b13ab7/html5/thumbnails/17.jpg)
1717
![Page 18: Pharmacology of general anesthetics Dr. Ashraf Arafat, MD Dr. Ashraf Arafat, MD Assistant Professor Department of Anesthesia, King Saud University 1](https://reader035.vdocuments.net/reader035/viewer/2022062300/56649e255503460f94b13ab7/html5/thumbnails/18.jpg)
Desflurane Desflurane Advantages:Advantages:
Rapid onset and recovery of anesthesia (useful for Rapid onset and recovery of anesthesia (useful for outpatient procedures)outpatient procedures)
One of least metabolized to toxic byproductsOne of least metabolized to toxic byproducts
Disadvantages:Disadvantages:Low volatility, so requires a special vaporizerLow volatility, so requires a special vaporizer
Pungent and irritating to the airway (leading to more Pungent and irritating to the airway (leading to more coughing, laryngospasm, so it is not as useful for coughing, laryngospasm, so it is not as useful for extended surgical procedures)extended surgical procedures)
High inspired gas concentrations lead to a significant High inspired gas concentrations lead to a significant increase in the patient’s BP & HR.increase in the patient’s BP & HR.
1818
![Page 19: Pharmacology of general anesthetics Dr. Ashraf Arafat, MD Dr. Ashraf Arafat, MD Assistant Professor Department of Anesthesia, King Saud University 1](https://reader035.vdocuments.net/reader035/viewer/2022062300/56649e255503460f94b13ab7/html5/thumbnails/19.jpg)
sevoflurane:sevoflurane:AdvantagesAdvantages::
Rapid onset and very rapid recovery of anesthesia Rapid onset and very rapid recovery of anesthesia (useful with children)(useful with children)
Not as pungent as desflurane (also useful with Not as pungent as desflurane (also useful with children) children)
Has good bronchodilating properties and is the agent Has good bronchodilating properties and is the agent of choice in patients with asthma, bronchitis, and COPD. of choice in patients with asthma, bronchitis, and COPD. It has little effect on the heart rate. It has little effect on the heart rate.
1919
![Page 20: Pharmacology of general anesthetics Dr. Ashraf Arafat, MD Dr. Ashraf Arafat, MD Assistant Professor Department of Anesthesia, King Saud University 1](https://reader035.vdocuments.net/reader035/viewer/2022062300/56649e255503460f94b13ab7/html5/thumbnails/20.jpg)
Disadvantages:Disadvantages:
Carbon dioxide absorbents in anesthesia Carbon dioxide absorbents in anesthesia machines degrade sevoflurane to a fluorinated machines degrade sevoflurane to a fluorinated hydrocarbon, which is degraded by renal lyase hydrocarbon, which is degraded by renal lyase enzymes to a thioacylhalide.enzymes to a thioacylhalide.
This compound has been observed to cause This compound has been observed to cause necrosis of the proximal tubule in rats. necrosis of the proximal tubule in rats.
2020
![Page 21: Pharmacology of general anesthetics Dr. Ashraf Arafat, MD Dr. Ashraf Arafat, MD Assistant Professor Department of Anesthesia, King Saud University 1](https://reader035.vdocuments.net/reader035/viewer/2022062300/56649e255503460f94b13ab7/html5/thumbnails/21.jpg)
Isoflurane:Isoflurane:
Advantages:Advantages:It causes peripheral vasodilation and increased It causes peripheral vasodilation and increased
coronary blood flow (useful in patients with ischemic coronary blood flow (useful in patients with ischemic heart disease)heart disease)
Disadvantages:Disadvantages:Moderate solubility, so recovery from anesthesia Moderate solubility, so recovery from anesthesia
may be delayedmay be delayed
Isoflurane can make the heart “more sensitive” to Isoflurane can make the heart “more sensitive” to circulating catecholamines (like epinephrine). circulating catecholamines (like epinephrine).
2121
![Page 22: Pharmacology of general anesthetics Dr. Ashraf Arafat, MD Dr. Ashraf Arafat, MD Assistant Professor Department of Anesthesia, King Saud University 1](https://reader035.vdocuments.net/reader035/viewer/2022062300/56649e255503460f94b13ab7/html5/thumbnails/22.jpg)
Halothane Halothane Used for induction in children (sweet Used for induction in children (sweet pleasant odor); pleasant odor);
Toxicity – cardiac arrhythmias, Toxicity – cardiac arrhythmias,
““halothane hepatitis” (rare). halothane hepatitis” (rare).
2222
![Page 23: Pharmacology of general anesthetics Dr. Ashraf Arafat, MD Dr. Ashraf Arafat, MD Assistant Professor Department of Anesthesia, King Saud University 1](https://reader035.vdocuments.net/reader035/viewer/2022062300/56649e255503460f94b13ab7/html5/thumbnails/23.jpg)
Nitrous OxideNitrous OxideNot used alone (except where full anesthesia Not used alone (except where full anesthesia not necessary; e.g. dental procedures);not necessary; e.g. dental procedures);
Causes more nausea/vomiting;Causes more nausea/vomiting; Contraindicated in patients with air filled cavities Contraindicated in patients with air filled cavities
(e.g. air embolus, pneumothorax, etc) or vitamin (e.g. air embolus, pneumothorax, etc) or vitamin B12 deficiency. B12 deficiency.
2323
![Page 24: Pharmacology of general anesthetics Dr. Ashraf Arafat, MD Dr. Ashraf Arafat, MD Assistant Professor Department of Anesthesia, King Saud University 1](https://reader035.vdocuments.net/reader035/viewer/2022062300/56649e255503460f94b13ab7/html5/thumbnails/24.jpg)
2424
![Page 25: Pharmacology of general anesthetics Dr. Ashraf Arafat, MD Dr. Ashraf Arafat, MD Assistant Professor Department of Anesthesia, King Saud University 1](https://reader035.vdocuments.net/reader035/viewer/2022062300/56649e255503460f94b13ab7/html5/thumbnails/25.jpg)
D. Neuromuscular blocking D. Neuromuscular blocking drugsdrugs
Used to perform tracheal intubation, facilitate Used to perform tracheal intubation, facilitate ventilation and to provide optimal surgical operating ventilation and to provide optimal surgical operating conditions, for example during laparotomy. conditions, for example during laparotomy.
2525
![Page 26: Pharmacology of general anesthetics Dr. Ashraf Arafat, MD Dr. Ashraf Arafat, MD Assistant Professor Department of Anesthesia, King Saud University 1](https://reader035.vdocuments.net/reader035/viewer/2022062300/56649e255503460f94b13ab7/html5/thumbnails/26.jpg)
Depolarizing(Succinycholine)Depolarizing(Succinycholine)Structurally similar to acetylcholine and function as Structurally similar to acetylcholine and function as competitive inhibitors. competitive inhibitors.
Very short duration of action Very short duration of action
Metabolized very quickly by an enzyme called Metabolized very quickly by an enzyme called plasma cholinesterase. plasma cholinesterase.
A useful drug in situations where muscle relaxation A useful drug in situations where muscle relaxation is needed for only a short time such as to facilitate is needed for only a short time such as to facilitate intubation. intubation.
2626
![Page 27: Pharmacology of general anesthetics Dr. Ashraf Arafat, MD Dr. Ashraf Arafat, MD Assistant Professor Department of Anesthesia, King Saud University 1](https://reader035.vdocuments.net/reader035/viewer/2022062300/56649e255503460f94b13ab7/html5/thumbnails/27.jpg)
Side effects :Side effects :Fasciculations .Fasciculations .
Muscle painMuscle pain
Bradycardia.Bradycardia.
Increases in ocular and gastric pressure,Increases in ocular and gastric pressure,
Hyperkalemia .Hyperkalemia .
Anaphylaxis. Anaphylaxis.
Malignant hyperthermia: a dramatic increase in Malignant hyperthermia: a dramatic increase in body temperature, acidosis, electrolyte imbalance body temperature, acidosis, electrolyte imbalance and shock and shock
2727
![Page 28: Pharmacology of general anesthetics Dr. Ashraf Arafat, MD Dr. Ashraf Arafat, MD Assistant Professor Department of Anesthesia, King Saud University 1](https://reader035.vdocuments.net/reader035/viewer/2022062300/56649e255503460f94b13ab7/html5/thumbnails/28.jpg)
Nondepolarizing blockersNondepolarizing blockersThey act by competitively blocking the binding of ACh to its receptors and inhibit muscular and inhibit muscular contraction. contraction.
2828
![Page 29: Pharmacology of general anesthetics Dr. Ashraf Arafat, MD Dr. Ashraf Arafat, MD Assistant Professor Department of Anesthesia, King Saud University 1](https://reader035.vdocuments.net/reader035/viewer/2022062300/56649e255503460f94b13ab7/html5/thumbnails/29.jpg)
Pancuronium bromide (Pavulon)Pancuronium bromide (Pavulon)
The first steroid NMBD in clinical use has a slow The first steroid NMBD in clinical use has a slow onset and long duration of action. onset and long duration of action.
It does not cause histamine releaseIt does not cause histamine release
Weak sympathomimetic properties and causes Weak sympathomimetic properties and causes tachycardia. tachycardia.
It is partly de-acylated in the liver to a metabolite It is partly de-acylated in the liver to a metabolite with neuromuscular blocking properties, and with neuromuscular blocking properties, and partly excreted unchanged in the urine. partly excreted unchanged in the urine.
Its action is prolonged in renal and hepatic Its action is prolonged in renal and hepatic impairment. impairment.
2929
![Page 30: Pharmacology of general anesthetics Dr. Ashraf Arafat, MD Dr. Ashraf Arafat, MD Assistant Professor Department of Anesthesia, King Saud University 1](https://reader035.vdocuments.net/reader035/viewer/2022062300/56649e255503460f94b13ab7/html5/thumbnails/30.jpg)
Atracurium besylate (Tracrium)Atracurium besylate (Tracrium)Widely used and have an intermediate onset and Widely used and have an intermediate onset and duration of action .duration of action .
It causes release of histamine but has no direct It causes release of histamine but has no direct cardiovascular effects.cardiovascular effects.
MetabolismMetabolism is by Hofmann degradation and ester is by Hofmann degradation and ester hydrolysis in the plasma, hence its duration of hydrolysis in the plasma, hence its duration of action is independent of renal and hepatic action is independent of renal and hepatic function. function.
A breakdown product of atracurium, A breakdown product of atracurium, laudanosinelaudanosine may accumulate due to very slow hepatic may accumulate due to very slow hepatic metabolism and upon crossing into the brain may metabolism and upon crossing into the brain may cause seizures cause seizures
3030
![Page 31: Pharmacology of general anesthetics Dr. Ashraf Arafat, MD Dr. Ashraf Arafat, MD Assistant Professor Department of Anesthesia, King Saud University 1](https://reader035.vdocuments.net/reader035/viewer/2022062300/56649e255503460f94b13ab7/html5/thumbnails/31.jpg)
Cisatracurium(Nimbex)Cisatracurium(Nimbex)
Isomer of atracuriumIsomer of atracurium
Less laudanosine formed .Less laudanosine formed .
Unlike atracurium it does not release histamine. Unlike atracurium it does not release histamine.
It is It is metabolised metabolised by Hofmann degradation and by Hofmann degradation and does not accumulate in renal failure. does not accumulate in renal failure.
3131
![Page 32: Pharmacology of general anesthetics Dr. Ashraf Arafat, MD Dr. Ashraf Arafat, MD Assistant Professor Department of Anesthesia, King Saud University 1](https://reader035.vdocuments.net/reader035/viewer/2022062300/56649e255503460f94b13ab7/html5/thumbnails/32.jpg)
Vecuronium Vecuronium bromide(Norcuron)bromide(Norcuron)
Vecuronium is structurally similar to pancuronium Vecuronium is structurally similar to pancuronium but has a slightly faster onset and shorter but has a slightly faster onset and shorter (intermediate) duration of action.(intermediate) duration of action.
It does not release histamine or have any It does not release histamine or have any cardiovascular effects. cardiovascular effects.
MetabolismMetabolism in the liver occurs active metabolites in the liver occurs active metabolites before being excreted in the bile and urine.before being excreted in the bile and urine.
Lack of dependence on good kidney function for Lack of dependence on good kidney function for elimination provide advantages over other elimination provide advantages over other neuromuscular blocking agents. neuromuscular blocking agents.
3232
![Page 33: Pharmacology of general anesthetics Dr. Ashraf Arafat, MD Dr. Ashraf Arafat, MD Assistant Professor Department of Anesthesia, King Saud University 1](https://reader035.vdocuments.net/reader035/viewer/2022062300/56649e255503460f94b13ab7/html5/thumbnails/33.jpg)
Rocuronium.Rocuronium. The most rapid onset of the clinically available The most rapid onset of the clinically available non-depolarizing NMBDs. Intubating conditions non-depolarizing NMBDs. Intubating conditions can be achieved in 60-90 seconds after an can be achieved in 60-90 seconds after an induction dose of 0.6 mg/Kg.induction dose of 0.6 mg/Kg.
An intermediate duration of action .An intermediate duration of action .
MetabolisedMetabolised in the liver and excreted in the bile. in the liver and excreted in the bile.
Minimal cardiovascular effects .Minimal cardiovascular effects .
Does not release histamine, Does not release histamine,
Higher incidence of anaphylactic reactions Higher incidence of anaphylactic reactions
3333
![Page 34: Pharmacology of general anesthetics Dr. Ashraf Arafat, MD Dr. Ashraf Arafat, MD Assistant Professor Department of Anesthesia, King Saud University 1](https://reader035.vdocuments.net/reader035/viewer/2022062300/56649e255503460f94b13ab7/html5/thumbnails/34.jpg)
Anticholinesterases Anticholinesterases (Neostigmine)(Neostigmine)
(acetylcholinesterase inhibitors) are agents (acetylcholinesterase inhibitors) are agents
that inhibit the action of the acetylcholinesterase that inhibit the action of the acetylcholinesterase enzyme at the neuromuscular enzyme at the neuromuscular
junction. junction. Clinical tests of adequate resolution of Clinical tests of adequate resolution of
neuromuscular block include the ability to lift the neuromuscular block include the ability to lift the head from the bed for 5 seconds, head from the bed for 5 seconds,
No role for anticholinesterases in reversing the No role for anticholinesterases in reversing the effects of suxamethonium. effects of suxamethonium.
3434
![Page 35: Pharmacology of general anesthetics Dr. Ashraf Arafat, MD Dr. Ashraf Arafat, MD Assistant Professor Department of Anesthesia, King Saud University 1](https://reader035.vdocuments.net/reader035/viewer/2022062300/56649e255503460f94b13ab7/html5/thumbnails/35.jpg)
Side effects Side effects
Bradycardia, miosis, GI upset, Bradycardia, miosis, GI upset,
Nausea, bronchospasm, increased bronchial Nausea, bronchospasm, increased bronchial secretions, sweating and salivation. secretions, sweating and salivation.
For this reason an antimuscarinic such as For this reason an antimuscarinic such as glycopyrronium or atropine must be administered glycopyrronium or atropine must be administered along with the anticholinesterase to minimise these along with the anticholinesterase to minimise these effects. effects.
3535
![Page 36: Pharmacology of general anesthetics Dr. Ashraf Arafat, MD Dr. Ashraf Arafat, MD Assistant Professor Department of Anesthesia, King Saud University 1](https://reader035.vdocuments.net/reader035/viewer/2022062300/56649e255503460f94b13ab7/html5/thumbnails/36.jpg)
3636