pharmacros collagen proactive bovine commercial presentation … · what is hydrolyzed collagen...

HIGH Q UA L I T Y F O O D S U P P L E M E N T O F H Y D R O LY Z E D C O L L A G E N

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Liquid Collagenpro-active bovine

Halal & Kosher Certified

WHAT IS COLLAGENCollagen is the protein that forms connective fibers in tissues such as:

Collagen is the key component of the basic structures of the human body and the connective tissue, composing:

▪ Collagen also acts as a kind of intracellular “glue” that gives support, shape and bulk to blood vessels, bones, and organs such

as the heart, kidneys and liver

▪ Collagen is also required to restore blood vessels, bruises, and broken bones

▪ It promotes lean muscle mass, skin beauty, increased energy and helps joint symptoms

▪ As the most abundant protein in the body, collagen accounts for more mass than all the other proteins put together

▪ Skin

▪ Ligaments

▪ Cartilage

▪ Tendons

▪ Joints

▪ Bones

▪ Gums

▪ Teeth

▪ 30% of the total body proteins ▪ 75% of the protein that makes up skin

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pro-active bovineLiquid Collagen

WHAT IS COLLAGEN

Collagen is responsible for:

▪ The outer body (skin and hair)

▪ The flexibility & mobility of the body’s structural components

▪ (cartilages & joints)

▪ The smooth functioning of internal organs

▪ The maintenance of good form for blood vessels and bone density

As we age, our organism tends to produce less collagen at a declining rate of about 1,5% per year from the age of 25 onwards.As a result, bones lose density, joints become more rigid, hair volume decreases, skin elasticity lessens and muscles weaken.The number and activity of skin cells (fibroblasts), that produce collagen, decreases. As fibroblasts become less active, thecollagen matrix which provides skin firmness and structure, starts to break down. Skin then becomes dehydrated and thinner,plus, fine lines, wrinkles and deep furrows start to appear.The ageing process is accelerated from several external factors:▪ pollution▪ smoking▪ excessive sun exposure

▪ stress▪ certain diseases▪ long-term use of certain drugs

Since sufficient quantity of Collagen cannot be provided through the consumption of different kind of food, therefore the intakeof Collagen is essential.

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WHAT IS HYDROLYZED COLLAGENHydrolyzed collagen, which is the leading form of collagen, is produced

through the process of enzymatic hydrolysis of collagen protein.

The process of hydrolysis involves breaking down the molecular bonds

between individual collagen strands using combinations of enzymes.

This process doesn’t use heat, chemicals or acids, but rather collagen is

dissolved in water.

The hydrolysis process results in reducing the collagen proteins of about

300,000 Da into small peptides having an average molecular weight

between 2000 and 5000 Da.

Clinical studies have shown that the percentage of bioavailability is more

than 90%1,2. Oral administration of hydrolysed collagen is absorbed

within the first 12 hours from the intake.

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WHAT IS HYDROLYZED COLLAGENHydrolyzed collagen contains 20 amino acids, which together represent around 50% of the total amino acid content.

Hydrolyzed Collagen’s peptides contain three times higher amount of proline,

glycine and hydroxyproline amino acids. These amino acids are essential for the

synthesis of new collagen and they strengthen the stability of collagen’s structure

in the body.

Amino acids %

Proline/Hydroxyproline 25%

Glycine 20%

Glutamic acid 11%

Arginine 8%

Alanine 8%

Other essential amino acids 16%

Other non-essential amino acids

12%


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WHY IS HYDROLYZED COLLAGEN SO IMPORTANT

Stimulation of collagen in the body has a positive impact on our health by revealing

a youthful, vibrant, fresh and vitalinner beauty

Hydrolyzed Collagen is too important for our body because:

▪ It is easily absorbed (high percentage of bioavailability)

▪ It releases three times more amino acids which are essential for the synthesis of new Collagen in the organism

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WHAT IS COLLAGEN PRO-ACTIVEPro-active bovine liquid collagen is a unique dietary supplement of a premium

Hydrolyzed Collagen, rich in specific amino acids that are easily absorbed by the human

body.

▪ Hydrolyzed Collagen (Type II) of high quality, enhanced with Vitamins B1, B2, B5, B6 & Magnesium

▪ With a very high percentage of oral absorption (more than 90%1,2)

▪ For women & men

▪ In liquid form

▪ Available in two delicious flavors of Strawberry & Lemon

▪ Fat-free

▪ Completely safe with no contraindications or side effects

Daily use of collagen Pro-active is clinically proven that reveals your younger self!

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Halal & Kosher Certified

COLLAGEN PRO-ACTIVE COMPOSITION

Each 25 ml (daily dose) contains:

Daily Dosage: A measuring cup per day diluted in a glass of water or juice, is recommended, preferably before evening sleep. Shake well before each use. Store in a cool and dry place, away from direct light and below 25°C.

Active Ingredients Per 25ml % RDA**

Hydrolyzed collagen* 10,000mg N/A

Magnesium 56,3mg 14,82%

Vitamin B5 6mg 100%

Vitamin B2 1.40mg 100%



*Bovine originated **RDA=Recommended Daily Allowance

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COLLAGEN PRO-ACTIVE PROPERTIESMagnesium (Mg) contributes to:• A reduction of tiredness and fatigue• Electrolyte balance• Normal energy yielding metabolism• Normal functioning of the nervous system• Normal muscle function / neurotransmission and muscle contraction including heart muscle

• Normal protein synthesis• Normal psychological function• The maintenance of normal bones• The maintenance of normal teeth• The process of cell division

Vitamin B5 (Pantothenic Acid):• Normal energy yielding metabolism • Normal mental performance• Normal synthesis and metabolism of steroid hormones,vitamin D and some neurotransmitters

•The reduction of tiredness and fatigue

Vitamin B6 (Pyridoxine):• Normal cysteine synthesis • Normal energy yielding metabolism • Normal functioning of the nervous system• Normal homocysteine metabolism• Normal protein and glycogen metabolism • Normal psychological function• Normal red blood cell formation• Normal function of the immune system • The reduction of tiredness and fatigue• The regulation of hormonal activity

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COLLAGEN PRO-ACTIVE PROPERTIESVitamin B2 (Riboflavin):• Normal energy yielding metabolism • Normal functioning of the nervous system• The maintenance of normal skin• The maintenance of normal red blood cells• The maintenance of normal mucous membranes • The maintenance of normal vision• The normal metabolism of iron • The protection of cells from oxidative stress / protection of DNA, proteins and lipids from

oxidative damage • The reduction of tiredness and fatigue

Vitamin B1 (Thiamine): Normal energy yielding metabolism Normal functioning of the nervous system Normal psychological functions Normal function of the heart

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MECHANISM OF ACTION (JOINT CARTILAGES)

The figure demonstrates the uniquemechanism of action of collagen.

When Pro-active bovine liquidcollagen is ingested, BioactiveCollagen Peptides (BCPs) areabsorbed and pass into jointcartilage, where they assist thecollagen synthesis.

Additionally, BCPs stimulate the anabolic phase of the cartilage matrix turnover and, over time, may helpimprove joint health. Thus, the potential exists for collagen to work on a molecular level with the metabolicprocess of cartilage and stimulate its regeneration.

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BENEFITS IN HEALTH▪ Provides a powerful antioxidant action19

▪ Activates energy production in the organism through Magnesium and Vitamins B5, B2, B6 & B1

▪ Contributes to the reduction of tiredness and fatigue through Magnesium and Vitamins B5, B2 & B6

▪ Contributes to the normal muscle function through maintenance and growth through Collagen Protein through Magnesium

▪ Promotes much easier sports and recreational activity3

▪ Contributes to decrease joint rigidity and mobility pain3

▪ Contributes to increase the articular cartilage thickness of joints4

▪ Reduces the risk of joint & cartilage injury and supports recovery time after physical activity4

▪ Contributes to increase the cartilage mass4

▪ Contributes to the normal function of bones through development and growth11

Clinically Proven

Effectiveness

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BENEFITS IN HEALTH▪ Assists in the improvement of Osteoarthritis and Osteoporosis10,11,12,17

▪ Promotes a normal function of the cardiovascular & nervous system through Magnesium and Vitamins B2, B6 & B1

▪ Affect the size of the collagen fibrils in the tendon & may improve the mechanical properties of the tendon9

▪ Contributes to normal psychological function & mental performance, while providing “anti-stress” properties through Vitamin B1

▪ Assists in the normal metabolism of fat and protein in the organism, while supporting active nutrition through Magnesium and Vitamins B5, B2, B6 & B1

▪ Maintains a healthy digestive tract14,15,16

▪ Maintains strong teeth and gums through Magnesium

Clinically Proven

Effectiveness

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BENEFITS IN BEAUTY▪ Enhances skin beauty

▪ Contributes to the maintenance of normal skin tonicity

▪ Contributes to the maintenance of skin elasticity & hydration6

▪ May help to fight against the visible signs of skin aging

▪ Contribute to the stimulatory effect of the Collagen biosynthesis in the body tissue13

▪ May function as a stimuli for fibroblasts to effect repair of damaged tissue8

▪ Improves skin’s dryness5

▪ Enhances hair strength and appearance from 5% to 45%7

Clinically Proven

Effectiveness

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(1) Asghar, A – 1982 chemical biochemical and functional characteristics of collagen—Advances in Food Research vol 28 p 231

(2) Oesser, S – 1999 oral administration of 14cgelatinhydrolasate Journal of Nutrition vol 129 p1891

(3) Arquel-Porcell, P. Pujol-Amat, 1996, Study on the action of a nutritional supplement that focuses on joint pain produced by osteoarthritis or joint aging in a population who regularly performs low-intensity exercise.

(4) J. Ll. Ribas, O. Molinero, 1998, Study on the effect of a nutritional supplement with gelatin hydrolysates that focuses on the prevention of sport injury.

(5) Sumada E, Hirota A et al.: The effect of oral ingest of collagen peptide on skin hydration and biochemical data on blood. J. Nutri Food 7

(6) Morganti P, Randazzo S, Bruno C 1988: Oral treatment of skin dryness. Cosmet Toilet. 103 77-80

(7) Study of Food and Nutrition Research Department of New Jersey (1976)

(8) Arnold E. POSTLETHWAITE, Jerome M. SEYER, Andrew H. KANG, Chemotactic attraction of human fibroblasts to type I, II, and III collagens and collagen-derived peptides, The Veterans Administration Hospital and Departments of Medicine and Biochemistry, University of Tennessee Center for the Health Sciences, Memphis, Tennessee 38104, Proc. Natl. Acad. Sci. USA, Cell Biology, Vol. 75, No. 2, pp. 871-875, February 1978

REFERENCES

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(9) Jun Minagughi 1, Yoh-ichi Koyama 3, Matsuko Meguri 1, Yoshinao hosaka 1, Hiromi Ueda 1, Masashi Kosubata 3, Arisa hirota 3, Shinkichi Irie 3, Naoki Mafune 2, Kazushige Takehana 1, Effects of Ingestion of Collagen Peptide on Collagen Fibrils and Glycosaminoglycans in Achilles Tendon, J Nutr Sci Vitaminol. 51, p. 169-174, 2005.

1 Department of Veterinary Anatomy, School of Veterinary Medicine,

2 Department of Food Science, School of Dairy Science, Rakuno Gakuen University, Hokkaido, 069-8501, Japan,

3 Nippi Research Institute of Biomatrix, Nippi Inc., Tokyo, 120-8601, Japan.

(10) Gulay Karaguzel, Michael F. Holick, Diagnosis and treatment of osteopenia, DOI 10.1007/s11154-010-9154-0, Rev EndocrMetab Disord (2010) 11:237–251, Springer Science+Business Media, LLC 2011.

(11) Roland W. Moskowitz, Role of Collagen Hydrolysate in Bone and Joint Disease, Seminars in Arthritis and Rheumatism, Vol. 30, No 2 (October), 2000: pp. 87-99.

(12) J. A. Pasco, E. Seeman, M. J. Henry, E. N. Merriman, G. C. Nicholson, M. A. Kotowicz, The population burden of fractures originates in women with osteopenia, not osteoporosis, Osteoporos Int (2006) 17: 1404–1409, DOI 10.1007/s00198-006-0135-9, International Osteoporosis Foundation and National Osteoporosis Foundation 2006.

REFERENCES

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(13) Steffen Oesser, Jurgen Seifert, Stimulation of type II collagen biosynthesis and secretion in bovine chondrocytes cultured with degraded collagen, Cell Tissue Res (2003) 311:393-399, DOI 0.1007/s00441-003-0702-8, Springer-Verlag 2003.

(14) http://www.naturalhealth365.com/food_news/gelatin.html

(15) http://www.vitalproteins.com/blog/healthy-digestion-collagen

(16) http://draxe.com/what-is-collagen/

(17) David E. Trentham, Roselynn A. Dynesius-Trentham, E. John Orav, Daniel Combitchi, Carlos Lorenzo, Kathryn Lea Sewell, David A. Hafler, Howard L. Weiner, Effects of Oral Administration of Type II Collagen on Rheumatoid Arthritis, Published in the prestigious journal Science, September 24, 1993.

(18) http://www.huffingtonpost.com/2012/06/22/fructose-sugar-moderation-diabetes_n_1618908.html

(19) Dr. E. Meucci, M. C. Mele, Amino acids and plasma antioxidant capacity, 1997, Volume 12, Issue 3-4, pp 373-377.

REFERENCES

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http://draxe.com/what-is-collagen/

http://www.huffingtonpost.com/2012/06/22/fructose-sugar-moderation-diabetes_n_1618908.html

CLINICAL STUDIES FOR PRO-ACTIVE BOVINE LIQUID COLLAGEN(3) A. Arquel-Porcell, P. Pujol-Amat (1996)

Study on the action of a nutritional supplement that focuses on joint pain produced by osteoarthritis or joint aging in a population who regularly performs low-intensity exercise.

The sociomedical implications were analyzed in a population aged over 65.

In order to evaluate the possible benefit of the nutritional supplement in this aged population, a naturally occurring hydrolyzed collagen compound enriched with magnesium and vitamin B complex, which acts on joint pain and helps play sports, was administered to 20 volunteers for 16 weeks.

The results of this study showed that test compound, which was well accepted and safe, improved the subjective and objective response to mobility and pain relief in 84.2% of subjects.

More specifically, the results obtained, show the action of test compound inducing a gradual and statistically significant decrease in the number of patients with strong and moderate pain, which became slight along the study duration.

Rigidity on starting movement decreased considerably in moderate or severe rigidity groups in respect to assessment at baseline. Groups show a significant amelioration of symptoms at week 4, 8, 12 and 16. At week 4 clinical improvement was already observed in 36.8% of patients and then reached up to 84.2% at week 16.

All the patients reported that the performance of their sports / recreational activity was much easier, especially because of a decrease of joint rigidity and mobility pain.

No side-effects were observed to the patients during or after the study.

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(4) J. Ll. Ribas, O. Molinero (1998)

Study on the effect of a nutritional supplement with gelatin hydrolysates that focuses on the prevention of sport injury.

The action of the nutritional supplement containing gelatine hydrolysate was assessed on articular cartilage thickness in sportsmen and sportswomen.

The administration of a daily dose of gelatine hydrolysate (10 g) enriched with vitamin B complex and magnesium for 6 months significantly increased the articular cartilage thickness of scapulohumeral joint and femorotibial joint. A 14% average increase was observed in treated patients.

In the control group, after the 6-month length of the study, not only there was any increase in articular cartilage thickness 16% but also a significant 13% decrease of cartilage biometrical values.

These results indicated that the long-term dosing of a gelatine hydrolysate enriched with vitamin B complex and magnesium to sportsmen and sportswomen may be useful in the prevention of joint injury.

More specifically, M. Adam (1991) reported that the oral administration of gelatine preparations improved the symptoms in 52 patients suffering from joint degeneration of hip and knee, while, Trentham et al (1993) observed a decrease in the number of painful joints in 60 patients with severe rheumatoid arthritis after oral administration of Type II collagen for three months. Additionally, Arquer and Pujol (1996) reported that in 20 patients, whose physical activity was limited to pain on movement, the administration for 16 weeks of a dietary supplementation containing highly purified gelatine hydrolysates produced a gradual and statistically significant decrease in the number of patients with strong and moderate pain together with reduction of rigidity on starting movement.

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CLINICAL STUDIES FOR PRO-ACTIVE BOVINE LIQUID COLLAGEN

CERTIFICATIONS & PATENTS

• FDA registration processed

• EU & Africa registered* (Spain, Hellas, Cyprus, Romania, Bulgaria, South Africa)

• Hydrolyzed Collagen Type II is the only Collagen peptides with Patent protection

within U.S.A. for the regeneration of cartilages

•Halal certified

•Kosher certified

*Free Sale Certificate has been issued by the Health Authorities of Spain and Bulgaria so far

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Pharmacros AD (Gr)80, Chlois str.,Metamorfosi, 14452,Athens, Greece+30 211 10 70 200

e-mail: [email protected] www.pharmacros.com

Pharmacros LP80, Chlois str.,Metamorfosi, 14452,Athens, Greece+30 211 10 70 270

pharmacros collagen proactive bovine commercial presentation … · what is hydrolyzed collagen...

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