phenoxodiol shows promising antitumour activity

Inpharma 1392 - 21 Jun 2003 Phenoxodiol shows promising antitumour activity Preclinical evidence suggests that the synthetic phenolic hormone analogue, phenoxodiol * , is an effective chemopreventive agent against 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary carcinogenesis, according to a multinational group of researchers. The diets of female Sprague-Dawley rats were supplemented with phenoxodiol at doses of 50 mg/kg (low-dose) and 75 mg/kg (high-dose). An unsupplemented group of rats served as controls. Mammary carcinomas were induced in all three groups of animals by DMBA injection one week after the mice began eating the experimental diets. At 120 days after DMBA treatment, tumour incidence rates were significantly lower in recipients of phenoxodiol 50 and 70 mg/kg, compared with controls (65% and 70% vs 94.7%, respectively). In addition, compared with the control diet, mean tumour multiplicity was significantly reduced in the low-dose and high-dose phenoxodiol diets (by 43% and 50%) and median tumour latency was significantly increased (by 32% and 39%). Survival of the phenoxodiol- supplemented rats was apparently higher than that of controls, although the researchers comment that "this observation may be due to an unusually large number of animals that died in the control group for reasons unrelated to tumour burden". * Novogen; phase II in fallopian tube cancer, leukaemia, ovarian cancer and skin cancer Constantinou AI, et al. Phenoxodiol, a novel isoflavone derivative, inhibits dimethylbenz[a]anthracene (DMBA)-induced mammary carcinogenesis in female Sprague-Dawley rats. European Journal of Cancer 39: 1012-1018, May 2003 800941918 1 Inpharma 21 Jun 2003 No. 1392 1173-8324/10/1392-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved

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Inpharma 1392 - 21 Jun 2003

Phenoxodiol shows promisingantitumour activity

Preclinical evidence suggests that the syntheticphenolic hormone analogue, phenoxodiol*, is aneffective chemopreventive agent against7,12-dimethylbenz(a)anthracene (DMBA)-inducedmammary carcinogenesis, according to a multinationalgroup of researchers.

The diets of female Sprague-Dawley rats weresupplemented with phenoxodiol at doses of 50 mg/kg(low-dose) and 75 mg/kg (high-dose). Anunsupplemented group of rats served as controls.Mammary carcinomas were induced in all three groupsof animals by DMBA injection one week after the micebegan eating the experimental diets.

At 120 days after DMBA treatment, tumour incidencerates were significantly lower in recipients ofphenoxodiol 50 and 70 mg/kg, compared with controls(65% and 70% vs 94.7%, respectively). In addition,compared with the control diet, mean tumourmultiplicity was significantly reduced in the low-doseand high-dose phenoxodiol diets (by 43% and 50%) andmedian tumour latency was significantly increased (by32% and 39%). Survival of the phenoxodiol-supplemented rats was apparently higher than that ofcontrols, although the researchers comment that "thisobservation may be due to an unusually large number ofanimals that died in the control group for reasonsunrelated to tumour burden".* Novogen; phase II in fallopian tube cancer, leukaemia, ovariancancer and skin cancer

Constantinou AI, et al. Phenoxodiol, a novel isoflavone derivative, inhibitsdimethylbenz[a]anthracene (DMBA)-induced mammary carcinogenesis in femaleSprague-Dawley rats. European Journal of Cancer 39: 1012-1018, May2003 800941918

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