PRESENTED BY

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Alex Swarbrick, PhD

Associate Professor of Medicine at UNSW Sydney, Laboratory Head in the GarvanInstitute

of Medical Research, NHMRC Senior Research Fellow, Co-head of the Breast Translational

Oncology Program in the Kinghorn Cancer Center, Sydney, Australia

Carl June, MDDirector of the Center for Cellular Immunotherapies at the Perleman School of Medicine and

Director of the Parker Institute for Cancer Immunotherapy at the University of Pennsylvania

Paolo Ascierto, MDDirector, IRCCS Instituto Nazionale Tumori Fondazione G Pascale

Peggy Sotiropoulou, PhD

Director of Research & Development, Celyad, Mont-Saint-Guibert, Belgium

Aleix Prat, MD, PhD

Head Medical Oncology Department - Hospital Clinic of Barcelona, Head Translational Genomics

& Targeted Therapeutics in Solid Tumors Group, Institut d’Investigacions Biomèdiques August Pi i

Sunyer (IDIBAPS), Hospital Clinic of Barcelona, American Association for Cancer Research

Alessandra Cesano, MD, PhD

Chief Medical Officer at ESSA Pharmaceuticals

Moderators

Plenary Speakers

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SPEAKERS

Juraj Adamik, PhDResearch Scientist

Parker Institute for Cancer Immunotherapy

Jenny Cronin, PhDAssociate Product Manager

NanoString Technologies

Jan Davidson, MD, PhDSenior Director

Clinical Research, MacroGenics Inc.

Anushka Dikshit, PhDApplication Scientist

Advanced Cell Diagnostics

Kit Fuhrman, PhDGeoMX RNA Product Manager

NanoString Technologies

Sergio Rutella, MD, PhD, FRCPathProfessor of Cancer Immunotherapy

John van Geest Cancer Research Centre, School of

Science and Technology, Nottingham Trent University

William L. Hwang, MD, PhDClinical Fellow in Radiation Oncology

Massachusetts General Hospital, Radiation Oncology

Arutha Kulasinghe, PhDPeter Doherty NHMRC Early Career Fellow at the

Queensland University of Technology (QUT)

Lisa Rydén, MD, PhDProfessor i Kirurgi, Lund University, Medical

Faculty, dept of Clinical Sciences Lund, div of

Oncology and Surgery

Noemi Reguart, MD, PhDThoracic Oncology Consultant

Hospital Clínic de Barcelona

Erin Piazza, PhDSenior Bioinformatics Scientist

NanoString Technologies

Peter Nelson, MDProfessor of Medicine

University of Washington

E. Aubrey Thompson, PhDProfessor of Cancer Biology

Mayo Clinic Comprehensive Cancer Center

Jon Zugazagoitia, MD, PhDPhysician Scientist

Department of Medical Oncology Lung Cancer Unit

Dana Mustafa, PhDAssistant Professor

Group Leader of the Tumor Immuno-Pathology (TIP)

Laboratory, Erasmus University Medical Center

Melanie Spears, PhDPrincipal Research Scientist

Ontario Institute for Cancer Research

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Beijing CST Wednesday 20 May (11:00 AM-8:00 PM Beijing CST)

11:00 AM-1:00 PM Exhibits Hall/Poster Viewing/Networking

1:00 PM-1:45 PM Plenary Session. Speaker: Carl June

1:45 PM-2:00 PM Break

Spatial Biology Track Biomarker Discovery Track

2:00 PM-2:15 PM Moderator Alex Swarbrick Alessandra Cesano

The Promise of Spatial Biology Biomarker Discovery for Precision Medicine

2:15 PM-2:45 PM Speaker Alex Swarbrick Aubrey Thompson

Talk title:A Multi-omic single cell and spatial atlas of breast cancer reveals stromal suppression of anti-cancer immunity

Digital spatial mapping of the immune landscape of triple negative breast cancer reveals novel features of immune-tumor cell interaction

2:45 PM-3:15 PM Speaker William Hwang Jon Zugazagoitia

Talk title:

Single-nucleus RNA-seq reveals distinct intratumoral transcriptomic heterogeneity in treatment-naïve and chemoradiotherapy-treated primary pancreatic ductal adenocarcinoma

Discovery of biomarkers associated with benefit from PD-1 checkpoint blockade in non-small-cell lung cancer (NSCLC) using high-plex digital spatial profiling

3:15 PM-3:45 PM Break

3:45 PM-4:15 PM Speaker Arutha Kulasinghe Melanie Spears

Talk title:Highly multiplexed digital spatial profiling of the tumor microenvironment of head and neck squamous cell carcinoma patients treated with immune checkpoint therapy

Assessing immune biomarkers of response to anthracyclines in breast cancer

4:15 PM-4:45 PM Speaker Anushka Dikshit Dana Mustafa

Talk title:Molecularly Guided High Plex Spatial Profiling in the Tumor Microenvironment

The Immune Microenvironment of Pancreatic Cancer

4:45 PM-5:15 PM Speaker Kit Fuhrman Erin Piazza

Talk title:Cancer Transcriptome Atlas with NGS Readout – The essential tool for spatial genomics in oncology

Tumor Signaling 360 Panel: A 360° View of Altered Signaling Pathways in Cancer

5:15 PM-6:00 PM Exhibits/Poster Session/Networking

AGENDA

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Beijing CST Thursday 21 May (11:00 AM-7:30 PM Beijing CST)

11:00 AM-1:00 PM Exhibits Hall/Poster Viewing/Networking

1:00 PM-1:45 PM Plenary Session Speaker: Paolo Ascierto

1:45 PM-2:00 PM Break

Immuno-Oncology Track Clinical Applications Track

2:00-2:15 PM Moderator Peggy Sotirpoulou Aleix Prat

Advances in Immuno-oncology Leveraging Signatures in the Clinical Setting

2:15 PM-2:45 PM Speaker Peter Nelson Aleix Prat

Talk title:Spatial landscape of the immune microenvironment in metastatic prostate cancer using GeoMx™ Digital Spatial Profiler

Primary results of SOLTI-1402/CORALLEEN phase 2 trial of neoadjuvant ribociclib plus letrozole versus chemotherapy in PAM50 Luminal B early breast cancer: an open-label, multicenter, two-arm, randomized study

2:45 PM-3:15 PM Speaker Sergio Rutella Noemi Reguart

Talk title:Immune infiltration correlates with TP53 mutational status in a multi-cohort acute myeloid leukemia study

Lung Cancer Gene Fusion Assays using NanoString® nCounter® Technology

3:15 PM-3:45 PM Break

3:45 PM-5:15 PM Speaker Juraj Adamik Lisa Rydén

Talk title:Molecular and Immunologic Profiling of CD8 T Cell Responses in Patients Receiving a Multiple Antigen-Engineered Dendritic Cell Vaccine

Comparison of PAM50 intrinsic subtype profiles in matched primary and metastatic breast cancer samples from the CTC-MBC trial (NCT01322893) shows a significant shift towards more aggressive subtypes throughout tumor progression

5:15 PM-5:45 PM Speaker Jenny Cronin Jan Davidson

Talk title:GeoMx® Protein Offerings: Fully validated antibodies to meet your spatial profiling needs

Flotetuzumab (FLZ), an Investigational CD123 x CD3 Bispecific Dart® Protein-Induced Clustering of CD3+ T Cells and CD123+ AML Cells in Bone Marrow Biopsies Is Associated with Response to Treatment in Primary Refractory AML Patients

5:45 PM-6:30 PM Exhibits/Poster Session/Networking

AGENDA

Presenters Title

Dan Zollinger NanoString Technologies

Molecularly guided digital spatial profiling for highly multiplexed analysis of gene expression with spatial

and single cell resolution

Heather Ann Brauer NanoString Technologies

Using multi-omic profiling to unravel the complexity of triple-negative breast cancer (TNBC)

Sarah Church NanoString Technologies

Deep Spatial Profiling of the Immune Landscape of MSI and MSS Colorectal Tumors

Jessie Perez NanoString Technologies

Transcriptomic Characterization of Immune Response within Diverse Tumor Environments using the

NanoString® nCounter® PanCancer IO 360™ Assay

Yugi Ren NanoString Technologies

Genomic Characterization of Breast Cancer Heterogeneity using Breast Cancer 360™

Alan Huang NanoString Technologies

Fusion Gene Detection in Cell-free Plasma by NanoString Low Input Fusion assay

Parick Danaher NanoString Technologies

Updating immune cell deconvolution for the spatial genomics era

Jason Reeves NanoString Technologies

Enabling pathway analysis of RNA expression in formalin-fixed paraffin embedded tissues with the GeoMx™

DSP platform

©2020 NanoString Technologies, Inc. All rights reserved.

APR 2020 MK2433

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