populomics, personalized medicine

POPULOMICS AND PERSONALIZED MEDICINE

Bradford W. Hesse, PhDChief, NCI Health Comm. and Informatics Research

Friday, March 14, 14

Wired Magazine, July 2010

• Invested $50 million in Parkinson’s research

• Started public blog on LRRK2

• Is leveraging the power of “big data” to accelerate the science

• Helped found, with wife Anne Wojcicki, 23andMe


Data-Intensive Research Paradigm to Speed Discovery?

Traditional Model

• Hypothesis

• Studies

• Data aggregation

• Analysis

• Writing

• Submission

• Acceptance (NEJM)

• Publication

Time Elapsed: 6 years


Data-Intensive Research Paradigm to Speed Discovery?

Genetics Initiative

• Tool construction

• Recruitment

• Analysis

• Presentation

Time Elapsed: 8 months


A Fourth Paradigm in Science?


A New Era in Health?:,

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mAP OF DISIUPTILsE IWWDIIRTIORJ

The Institute for the Future’s Health Horizons Program hasdeveloped a new paradigm for disruptive innovation inthe global health economy—we call it “Open Health.” Thisparadigm leverages the concepts and successes of openinnovation and open-source software, and applies themto the world of health. Open Health strategies will redefinethe research and development process and will require aradically new way of thinking about innovation systems, theinstitutional culture of firms, partnerships, and collaborations,and the very meaning of health itself. The implications ofOpen Health are relevant to all stakeholders in the globalhealth economy, be they beauty, food, consumer electronics,biopharma, health care, or medical technology companies.As it diffuses across industries, Open Health will inspire newapproaches to meeting significant global health problems,and it will provide a framework for generating and sustainingnew business models of tomorrow.

We have identified ten core principles that serve as afoundation for implementing Open Health strategies. This mappresents these principles in the context of emerging trendsand innovation leaders. It describes the external forces that aredriving Open Health and emphasizes the networks and culture,the ethos and skills, the business models and strategies, andthe tools and platforms that will shape innovation systems inthe global health economy over the next decade.

The Open Health Map of Disruptive Innovation (SR-1117A)is your guide to putting Open Health into practice. Use it,along with its companion piece, the Open Health Toolkit: AFramework for Innovation (SR-1117B), to build the capacity toinnovate to solve health’s pressing problems.

A Fourth Paradigm in Science?


A Fourth Paradigm in Science?Molecules to Populations

Genomics

Nanotechnology

ProteomicsPopulomics

Forman MR, Greene SM, Avis NE, et al. Bioinformatics: Tools to accelerate population science and disease control research. Am J Prev Med. Jun 2010;38(6):646-651.


https://cabig.nci.nih.gov/participants

https://cabig.nci.nih.gov/participants

http://images.google.com/imgres?imgurl=http://genetics.gsk.com/graphics/dna-big.gif&imgrefurl=http://genetics.gsk.com/overview.htm&h=615&w=314&sz=29&hl=en&start=9&tbnid=vadS5SMaoT5uZM:&tbnh=136&tbnw=69&prev=/images%253Fq%253Dgenetic%252Bresearch%2526svnum%253D10%2526hl%253Den%2526lr%253D

http://images.google.com/imgres?imgurl=http://genetics.gsk.com/graphics/dna-big.gif&imgrefurl=http://genetics.gsk.com/overview.htm&h=615&w=314&sz=29&hl=en&start=9&tbnid=vadS5SMaoT5uZM:&tbnh=136&tbnw=69&prev=/images%253Fq%253Dgenetic%252Bresearch%2526svnum%253D10%2526hl%253Den%2526lr%253D

Platforms for participation

Harnessing collective intelligence

Data as the new “Intel Inside”

End of the software release cycle

Lightweight programming models

Software above the level of the single device

Rich user experience

From Web 2.0 to Health 2.0

*Source: http://oreilly.com/web2/archive/what-is-web-20.html

Facets of Web 2.0*


http://oreilly.com/web2/archive/what-is-web-20.html


Platforms for participation







From Web 2.0 to Health 2.0

*Source: http://oreilly.com/web2/archive/what-is-web-20.html

Facets of Web 2.0*Facets of Web 2.0*Platforms for participation










Hesse B, W. , Sproull L, Kiesler SB, Walsh JP. Returns to science: computer networks in oceanography. Commun. ACM. 1993;36(8):90-101.


Hesse B, W. , Sproull L, Kiesler SB, Walsh JP. Returns to science: computer networks in oceanography. Commun. ACM. 1993;36(8):90-101.

• Data Liquidity


Hesse, B. W., Hansen, D., Finholt, T., Munson, S., Kellogg, W., & Thomas, J. C. (2010). Social Participation in Health 2.0. IEEE Computer, 43(12), 45-52.

• Platforms for Participation• Harnessing Collective Intelligence


• Software above single device

Hesse BW. Enhancing Consumer Involvement in Health Care. In: Parker JC, Thornson E, eds. Health Communication in the New Media Landscape. New York, NY: Springer Publishing Company; 2008:119-149.


Hesse BW. Time to reboot: resetting health care to support tobacco dependency treatment services. Am J Prev Med. Dec 2010;39(6 Suppl 1):S85-87.

ClearPractice, Inc. • Rich User Experience


The Learning Healthcare System

Hesse BW, Woods SS, Ahern DK. Nudging Best Practice: The HITECH Act and Behavioral Medicine. Translational Behavioral Medicine. 2011;1(1):175-181.


Hesse BW. Public Health Informatics. In: Gibbons MC, editor. eHealth Solutions for Healthcare Disparities. New York, NY: Springer; 2007. p. 109-129.

Data-informed Personalized Medicine


Stay Tuned!


populomics, personalized medicine

Health & Medicine

health care

nci health

open health strategies

health communica

meaning of health

world of health

open health toolkit

implications of open