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4thFloor Philippine Pediatric Society (PPS) Building, 52 Kalayaan Avenue, Barangay Malaya, Quezon City 1105 PhilippinesTelephone: (632) 434-3946 Mobile: (63-922) 8019057 E-mail address: devpedphil@gmail.com

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Philippine Society for Developmental and Behavioral Pediatrics

Position Statement on Stem Cell Therapy for Neurodevelopmental

and Behavioral DisordersPhilippine Society for Developmental and Behavioral Pediatrics

October 8, 2013

The society acknowledges the potential of using stem cell therapy as a

treatment option for developmental disabilities. However, there is

currently no strong scientific evidence to recommend the use of stem

cells as treatment for neurodevelopmental disorders, developmental

disabilities and central nervous system disorders including but not limited to

autism spectrum disorder, cerebral palsy, global developmental delay and

intellectual disability. Since the long term safety and effectiveness of the

use of stem cells in humans have not been established at this time, its use

for these conditions should be confined to well-designed clinical trials

that include the necessary ethical, scientific and regulatory controls.

At present, the society strongly encourages the use of evidence-based

interventions for developmental and behavioral conditions, under the

guidance and recommendation of a Developmental-Behavioral Pediatrician

or Neurodevelopmental Pediatrician duly board certified to practice in the

Philippines.

References:Borlongan CV, Weiss MD. Baby STEPS: a giant leap for cell therapy in neonatal brain injury. Pediatr Res. 2011Jul;70(1):3-9.

Chen G, Wang Y, Xu Z, Fang F, Xu R, Wang Y, Hu X, Fan L, Liu H. Neural stem cell-like cells derived fromautologous bone mesenchymal stem cells for the treatment of patients with cerebral palsy. J Transl Med. 2013Jan 26;11:21.

Gaspard N, Vanderhaeghen P. From stem cells to neural networks: recent advances and perspectives forneurodevelopmental disorders. Dev Med Child Neurol. 2011 Jan;53(1):13-7.

Daley GQ. The promise and perils of stem cell therapeutics. Cell Stem Cell. 2012 Jun 14;10(6):740-9.

Ichim TE, Solano F, Glenn E, Morales F, Smith L, Zabrecky G, Riordan NH. Stem cell therapy for autism. JTransl Med. 2007 Jun 27;5:30.

Kiskinis E, Eggan K. Progress toward the clinical application of patient-specific pluripotent stem cells. J ClinInvest. 2010 Jan;120(1):51-9.

Li M, Yu A, Zhang F, Dai G, Cheng H, Wang X, An Y. Treatment of one case of cerebral palsy combined withposterior visual pathway injury using autologous bone marrow mesenchymal stem cells. J Transl Med. 2012 May18;10:100.

Lv YT, Zhang Y, Liu M, Qiuwaxi JN, Ashwood P, Cho SC, Huan Y, Ge RC, Chen XW, Wang ZJ, Kim BJ, Hu X.Transplantation of human cord blood mononuclear cells and umbilical cord-derived mesenchymal stem cells inautism. J Transl Med. 2013 Aug 27;11(1):196.

Pabon MM, Borlongan CV. Advances in the cell-based treatment of neonatal hypoxic-ischemic brain injury.Future Neurol. 2013 Mar 1;8 2 :193-203.

OFFICERS and BOARD OFTRUSTEES 2013

PresidentMa. Theresa Arranz-Lim, MD

Vice-President Bernadette Carpio-Benitez, MD

SecretaryJacqueline O. Navarro, MD

Assistant SecretaryErmenilda L. Avendao, MD

TreasurerRita Paz Rowena A. De Guzman, MD

Assistant TreasurerAgnes G. Falcotelo, MD

PROMa. Rochelle B. Pacifico, MD

PPS LiaisonMa. Noemi T. Salazar, MD

Awards and MembershipStella G. Manalo, MD

Immediate Past PresidentJoselyn A. Eusebio, MD

Founding PresidentPerla D. Santos Ocampo, MD

8/13/2019 Position Paper on Stem Cell Therapy 131008

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4thFloor Philippine Pediatric Society (PPS) Building, 52 Kalayaan Avenue, Barangay Malaya, Quezon City 1105 PhilippinesTelephone: (632) 434-3946 Mobile: (63-922) 8019057 E-mail address: devpedphil@gmail.com

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Philippine Society for Developmental and Behavioral Pediatrics

References (continued)

Regenberg AC, Hutchinson LA, Schanker B, Mathews DJ. Medicine on the fringe: stem cell-based interventions in advance of evidence. Stem Cells. 2009

Sep;27(9):2312-9.

Siniscalco D, Bradstreet JJ, Antonucci N. Therapeutic role of hematopoietic stem cells in autism spectrum disorder-related inflammation. Front Immunol.2013;4:140.

Siniscalco D, Sapone A, Cirillo A, Giordano C, Maione S, Antonucci N. Autism spectrum disorders: is mesenchymal stem cell personalized therapy the future?J Biomed Biotechnol. 2012;2012:480289.

Vaccarino FM, Urban AE, Stevens HE, Szekely A, Abyzov A, Grigorenko EL, Gerstein M, Weissman S. Annual Research Review: The promise of stem cellresearch for neuropsychiatric disorders. J Child Psychol Psychiatry. 2011 Apr;52(4):504-16.

Wang F, Maeda N, Yasuhara T, Kameda M, Tsuru E, Yamashita T, Shen Y, Tsuda M, Date I, Sagara Y. The therapeutic potential of human umbilical cordblood transplantation for neonatal hypoxic-ischemic brain injury and ischemic stroke. Acta Med Okayama. 2012;66(6):429-34.