postdoctoral position in viral oncogenesis · 2020-01-07 · 2. protein-mediated viral latency is a...
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POSTDOCTORAL POSITION IN VIRAL ONCOGENESIS
University of Pittsburgh Cancer Virology Program http://www.tumorvirology.pitt.edu
• Eligible for $60,000 Hillman Postdoc Award annual salary, plus $10,000 educational bonus • Supported by NIH NCI R35 Outstanding Investigator and R01 Awards. Our laboratory investigates two human cancer viruses we discovered, KSHV/HHV8 and Merkel cell polyomavirus, and develops new technologies to discover other human tumor viruses. Current projects involve studies on viral circular RNAs, SCF E3 ligase targeting of viral proteins, mitotic translation regulation and new virus discovery. Strong molecular biology skills are required. Expertise in transcriptomics/proteomics, mass spectrometry, immunohistochemistry, UNIX-based bioinformatics, and virology are helpful, though not required. But enthusiasm to learn these and other techniques is essential. Pittsburgh is beautiful and affordable with tremendous cultural and outdoor resources (www.huffpost.com/entry/pittsburgh-health_n_4339476). The Hillman Cancer Center’s Cancer Virology Program is a leading international academic center for research on cancer and infection.
Patrick S. Moore ([email protected]) and Yuan Chang ([email protected]), Cancer Virology Program Reseach Pav 1.8, University of Pittsburgh Hillman Cancer Center 5117 Centre Ave, Pittsburgh, PA 15213
EBV circular RNAs
circBARTs
Divergent Primer Pair
A
p4E-BP1S65/S101
total 4E-BP1
p4E-BP1T37/T46
Empty sT
αTubulin
sT
αβγδ
αβγδ
αβγδ
Empty sT
Basic
γβα
δ
Acidic Acidic Basic
B
total 4E-BP1
0 2 4 6 12 24
αTubulin
p4E-BP1T37/T46
sT
p4E-BP1S65/S101
PP242 (h)
Empty sT sTmLSD
0 2 4 6 12 24 0 2 4 6 12 24 γβα
δ
γβα
δ
γβα
δ
γβα
δ
γβα
δ
HPyV7:NewHumanPathogen MCVsTregulationofmitotic4E-BP1
Virus-encodedcircularRNAs Proteomicapproachesfortumor-virusdiscovery
Recent Publications: 1. Circular DNA tumor viruses make circular RNAs. PNAS 115:E8737-E8745;2018. 2. Protein-mediated viral latency is a novel mechanism for Merkel cell polyomavirus persistence. PNAS 114:E4040-E4047;
2017. 3. Mitotic protein kinase CDK1 phosphorylation of mRNA translation regulator 4E-BP1 Ser83 may contribute to cell
transformation. PNAS 113(30):8466-71; 2016 4. Human polyomavirus 7-associated pruritic rash and viremia in transplant recipients. J Infect Dis 211:1560-5; 2015. https://scholar.google.com/citations?user=C0GXFrwAAAAJ&hl=en&oi=ao