Poster Draft from Bioengineering’s Capstone

Design Course

NanoStitch

Cutting-edge nanoshell technology offers a new wave of biomedical research that can be directly applied to the clinical setting. While current methods of wound closure, such as sutures and liquid adhesives, encounter problems arising from scarring, cost, infection and inconvenience, current research has shown promising results for the implementation of nanoshells in the field of laser tissue welding1. A significant setback to current laser wound closure techniques is the large user variability. To address the pitfalls of previous wound closure techniques, Team Lazer has designed and built a prototype of an easily applicable device and a user-friendly program to address the concerns of safety and consistency arising from the variables of laser distance, angle, and motion along with the surface temperature of the skin.

1. Gobin AM, O'neal DP, Watkins DM, Halas NJ, Drezek RA, West JL. Near infrared laser-tissue welding using nanoshells as an exogenous absorber. Lasers Surg Med. 2005 Aug;37(2):123-9.

Special Thanks to:• Andre Gobin• Dr. Jennifer West, Rice University• Dr. Oden, Rice University• CBEN• Brown Foundation Teaching Grant

Introduction

Device Concept

A Nanoshell Assisted Laser Tissue Welding Device Team Lazer, Rice University

Presented by Karl Balsara, Marc Burrell, Mike Cordray and Sanjay Maniar

Temperature Sensor

Laser Mounting Bracket

Motor

DampenedArm

ProximitySensor

Prototype Requirements

• Easily Portable

• Costs < $1500

• Volume < 3ft³

• Sensing Distance: 2-10cm

• Depth of Laser Penetration: 2-3mm

• User-friendly computer interface

Safety Concerns Addressed

• Size of Wound: 2-5cm

• Maximum Safety

• Highly Consistent

• Highly Repeatable

Patient Safety

• Temperature monitoring prevents damage to skin

• Modulated laser intensity to prevent burns

• Reduced manipulation of wound Less opportunity for infection

• Motorized angle adjustment allows for consistent application to skin

User Safety

• User interface alarms operator when critical temperature is reached

• Proximity to skin determined in real-time

• Automatic Shut-off System

Technical Specifications

Laser• FAP I Laser System made by Coherent Inc.,• Output: 14 W/cm²• Spot Size: 5 mm spot size

Solder Solution• Gold nanoshells peak absorbance of 821 nm • Nanoshell suspension of 7x1010 particles/ml

Temperature Sensor• Raytek MI Series• System response time of 150 ms

Proximity Sensor• Banner U-Gage S18U Analog Sensor• Measures distance between 3cm – 30cm

Software• Built in LABVIEW, easily upgradable • Easy to use Interface

Conclusions

• Current methods of wound closure are inconvenient and increase patient’s susceptibility to infection and scarring

• Incorporation of distance and temperature sensors into a user-friendly software program results in a safer and more consistent wound closure

Safe and Effective Solution

Acknowledgments and References

User Interface

• Visible alarms

• Temperature at wound and distance to wound highly visible

• Emergency stop button to cut laser power

• Easy calibration to ensure consistency between trials

• Visible indication of current laser power

Nanostitch

• Insert graph of tensile strength of Nanostitch vs. Suture

•Results coming

•Insert table of Nanostitch vs handheld laser application to show increased consistency (lower standard deviation) for device

•Results coming

NanoStitch

Cutting-edge nanoshell technology offers a new wave of biomedical research that can be directly applied to the clinical setting. While current methods of wound closure, such as sutures and liquid adhesives, encounter problems arising from scarring, cost, infection and inconvenience, current research has shown promising results for the implementation of nanoshells in the field of laser tissue welding1. A significant setback to current laser wound closure techniques is the large user variability. To address the pitfalls of previous wound closure techniques, Team Lazer has designed and built a prototype of an easily applicable device and a user-friendly program to address the concerns of safety and consistency arising from the variables of laser distance, angle, and motion along with the surface temperature of the skin.

1. Gobin AM, O'neal DP, Watkins DM, Halas NJ, Drezek RA, West JL. Near infrared laser-tissue welding using nanoshells as an exogenous absorber. Lasers Surg Med. 2005 Aug;37(2):123-9.

Special Thanks to:• Andre Gobin• Dr. Jennifer West, Rice University• Dr. Oden, Rice University• CBEN• Brown Foundation Teaching Grant

Introduction

Device Concept

A Nanoshell Assisted Laser Tissue Welding Device Team Lazer, Rice University

Presented by Karl Balsara, Marc Burrell, Mike Cordray and Sanjay Maniar

Temperature Sensor

Laser Mounting Bracket

Motor

DampenedArm

ProximitySensor

Prototype Requirements

• Easily Portable

• Costs < $1500

• Volume < 3ft³

• Sensing Distance: 2-10cm

• Depth of Laser Penetration: 2-3mm

• User-friendly computer interface

Safety Concerns Addressed

• Size of Wound: 2-5cm

• Maximum Safety

• Highly Consistent

• Highly Repeatable

Patient Safety

• Temperature monitoring prevents damage to skin

• Modulated laser intensity to prevent burns

• Reduced manipulation of wound Less opportunity for infection

• Motorized angle adjustment allows for consistent application to skin

User Safety

• User interface alarms operator when critical temperature is reached

• Proximity to skin determined in real-time

• Automatic Shut-off System

Technical Specifications

Laser• FAP I Laser System made by Coherent Inc.,• Output: 14 W/cm²• Spot Size: 5 mm spot size

Solder Solution• Gold nanoshells peak absorbance of 821 nm • Nanoshell suspension of 7x1010 particles/ml

Temperature Sensor• Raytek MI Series• System response time of 150 ms

Proximity Sensor• Banner U-Gage S18U Analog Sensor• Measures distance between 3cm – 30cm

Software• Built in LABVIEW, easily upgradable • Easy to use Interface

Conclusions

• Current methods of wound closure are inconvenient and increase patient’s susceptibility to infection and scarring

• Incorporation of distance and temperature sensors into a user-friendly software program results in a safer and more consistent wound closure

Safe and Effective Solution

Acknowledgments and References

User Interface

• Visible alarms

• Temperature at wound and distance to wound highly visible

• Emergency stop button to cut laser power

• Easy calibration to ensure consistency between trials

• Visible indication of current laser power

Nanostitch

• Insert graph of tensile strength of Nanostitch vs. Suture

•Results coming

•Insert table of Nanostitch vs handheld laser application to show increased consistency (lower standard deviation) for device

•Results coming

Add Dept. of BIOE and contact info

Cut

NanoStitch

Cutting-edge nanoshell technology offers a new wave of biomedical research that can be directly applied to the clinical setting. While current methods of wound closure, such as sutures and liquid adhesives, encounter problems arising from scarring, cost, infection and inconvenience, current research has shown promising results for the implementation of nanoshells in the field of laser tissue welding1. A significant setback to current laser wound closure techniques is the large user variability. To address the pitfalls of previous wound closure techniques, Team Lazer has designed and built a prototype of an easily applicable device and a user-friendly program to address the concerns of safety and consistency arising from the variables of laser distance, angle, and motion along with the surface temperature of the skin.

1. Gobin AM, O'neal DP, Watkins DM, Halas NJ, Drezek RA, West JL. Near infrared laser-tissue welding using nanoshells as an exogenous absorber. Lasers Surg Med. 2005 Aug;37(2):123-9.

Special Thanks to:• Andre Gobin• Dr. Jennifer West, Rice University• Dr. Oden, Rice University• CBEN• Brown Foundation Teaching Grant

Introduction

Device Concept

A Nanoshell Assisted Laser Tissue Welding Device Team Lazer, Rice University

Presented by Karl Balsara, Marc Burrell, Mike Cordray and Sanjay Maniar

Temperature Sensor

Laser Mounting Bracket

Motor

DampenedArm

ProximitySensor

Prototype Requirements

• Easily Portable

• Costs < $1500

• Volume < 3ft³

• Sensing Distance: 2-10cm

• Depth of Laser Penetration: 2-3mm

• User-friendly computer interface

Safety Concerns Addressed

• Size of Wound: 2-5cm

• Maximum Safety

• Highly Consistent

• Highly Repeatable

Patient Safety

• Temperature monitoring prevents damage to skin

• Modulated laser intensity to prevent burns

• Reduced manipulation of wound Less opportunity for infection

• Motorized angle adjustment allows for consistent application to skin

User Safety

• User interface alarms operator when critical temperature is reached

• Proximity to skin determined in real-time

• Automatic Shut-off System

Technical Specifications

Laser• FAP I Laser System made by Coherent Inc.,• Output: 14 W/cm²• Spot Size: 5 mm spot size

Solder Solution• Gold nanoshells peak absorbance of 821 nm • Nanoshell suspension of 7x1010 particles/ml

Temperature Sensor• Raytek MI Series• System response time of 150 ms

Proximity Sensor• Banner U-Gage S18U Analog Sensor• Measures distance between 3cm – 30cm

Software• Built in LABVIEW, easily upgradable • Easy to use Interface

Conclusions

• Current methods of wound closure are inconvenient and increase patient’s susceptibility to infection and scarring

• Incorporation of distance and temperature sensors into a user-friendly software program results in a safer and more consistent wound closure

Safe and Effective Solution

Acknowledgments and References

User Interface

• Visible alarms

• Temperature at wound and distance to wound highly visible

• Emergency stop button to cut laser power

• Easy calibration to ensure consistency between trials

• Visible indication of current laser power

Nanostitch

• Insert graph of tensile strength of Nanostitch vs. Suture

•Results coming

•Insert table of Nanostitch vs handheld laser application to show increased consistency (lower standard deviation) for device

•Results coming

NanoStitch

Cutting-edge nanoshell technology offers a new wave of biomedical research that can be directly applied to the clinical setting. While current methods of wound closure, such as sutures and liquid adhesives, encounter problems arising from scarring, cost, infection and inconvenience, current research has shown promising results for the implementation of nanoshells in the field of laser tissue welding1. A significant setback to current laser wound closure techniques is the large user variability. To address the pitfalls of previous wound closure techniques, Team Lazer has designed and built a prototype of an easily applicable device and a user-friendly program to address the concerns of safety and consistency arising from the variables of laser distance, angle, and motion along with the surface temperature of the skin.

1. Gobin AM, O'neal DP, Watkins DM, Halas NJ, Drezek RA, West JL. Near infrared laser-tissue welding using nanoshells as an exogenous absorber. Lasers Surg Med. 2005 Aug;37(2):123-9.

Special Thanks to:• Andre Gobin• Dr. Jennifer West, Rice University• Dr. Oden, Rice University• CBEN• Brown Foundation Teaching Grant

Introduction

Device Concept

A Nanoshell Assisted Laser Tissue Welding Device Team Lazer, Rice University

Presented by Karl Balsara, Marc Burrell, Mike Cordray and Sanjay Maniar

Temperature Sensor

Laser Mounting Bracket

Motor

DampenedArm

ProximitySensor

Safety Concerns Addressed

• Size of Wound: 2-5cm

• Maximum Safety

• Highly Consistent

• Highly Repeatable

Patient Safety

• Temperature monitoring prevents damage to skin

• Modulated laser intensity to prevent burns

• Reduced manipulation of wound Less opportunity for infection

• Motorized angle adjustment allows for consistent application to skin

User Safety

• User interface alarms operator when critical temperature is reached

• Proximity to skin determined in real-time

• Automatic Shut-off System

Technical Specifications

Laser• FAP I Laser System made by Coherent Inc.,• Output: 14 W/cm²• Spot Size: 5 mm spot size

Solder Solution• Gold nanoshells peak absorbance of 821 nm • Nanoshell suspension of 7x1010 particles/ml

Temperature Sensor• Raytek MI Series• System response time of 150 ms

Proximity Sensor• Banner U-Gage S18U Analog Sensor• Measures distance between 3cm – 30cm

Software• Built in LABVIEW, easily upgradable • Easy to use Interface

Conclusions

• Current methods of wound closure are inconvenient and increase patient’s susceptibility to infection and scarring

• Incorporation of distance and temperature sensors into a user-friendly software program results in a safer and more consistent wound closure

Safe and Effective Solution

Acknowledgments and References

User Interface

• Visible alarms

• Temperature at wound and distance to wound highly visible

• Emergency stop button to cut laser power

• Easy calibration to ensure consistency between trials

• Visible indication of current laser power

Nanostitch

• Insert graph of tensile strength of Nanostitch vs. Suture

•Results coming

•Insert table of Nanostitch vs handheld laser application to show increased consistency (lower standard deviation) for device

•Results coming

Good decision to use bold to call attention to description of your design, but this large block of text doesn’t provide an easy entry point into the poster. Reorganize and edit!

NanoStitch

Cutting-edge nanoshell technology offers a new wave of biomedical research that can be directly applied to the clinical setting. While current methods of wound closure, such as sutures and liquid adhesives, encounter problems arising from scarring, cost, infection and inconvenience, current research has shown promising results for the implementation of nanoshells in the field of laser tissue welding1. A significant setback to current laser wound closure techniques is the large user variability. To address the pitfalls of previous wound closure techniques, Team Lazer has designed and built a prototype of an easily applicable device and a user-friendly program to address the concerns of safety and consistency arising from the variables of laser distance, angle, and motion along with the surface temperature of the skin.

1. Gobin AM, O'neal DP, Watkins DM, Halas NJ, Drezek RA, West JL. Near infrared laser-tissue welding using nanoshells as an exogenous absorber. Lasers Surg Med. 2005 Aug;37(2):123-9.

Special Thanks to:• Andre Gobin• Dr. Jennifer West, Rice University• Dr. Oden, Rice University• CBEN• Brown Foundation Teaching Grant

Introduction

Device Concept

A Nanoshell Assisted Laser Tissue Welding Device Team Lazer, Rice University

Presented by Karl Balsara, Marc Burrell, Mike Cordray and Sanjay Maniar

Temperature Sensor

Laser Mounting Bracket

Motor

DampenedArm

ProximitySensor

Prototype Requirements

• Easily Portable

• Costs < $1500

• Volume < 3ft³

• Sensing Distance: 2-10cm

• Depth of Laser Penetration: 2-3mm

• User-friendly computer interface

Safety Concerns Addressed

• Size of Wound: 2-5cm

• Maximum Safety

• Highly Consistent

• Highly Repeatable

Patient Safety

• Temperature monitoring prevents damage to skin

• Modulated laser intensity to prevent burns

• Reduced manipulation of wound Less opportunity for infection

• Motorized angle adjustment allows for consistent application to skin

User Safety

• User interface alarms operator when critical temperature is reached

• Proximity to skin determined in real-time

• Automatic Shut-off System

Technical Specifications

Laser• FAP I Laser System made by Coherent Inc.,• Output: 14 W/cm²• Spot Size: 5 mm spot size

Solder Solution• Gold nanoshells peak absorbance of 821 nm • Nanoshell suspension of 7x1010 particles/ml

Temperature Sensor• Raytek MI Series• System response time of 150 ms

Proximity Sensor• Banner U-Gage S18U Analog Sensor• Measures distance between 3cm – 30cm

Software• Built in LABVIEW, easily upgradable • Easy to use Interface

Conclusions

• Current methods of wound closure are inconvenient and increase patient’s susceptibility to infection and scarring

• Incorporation of distance and temperature sensors into a user-friendly software program results in a safer and more consistent wound closure

Safe and Effective Solution

Acknowledgments and References

User Interface

• Visible alarms

• Temperature at wound and distance to wound highly visible

• Emergency stop button to cut laser power

• Easy calibration to ensure consistency between trials

• Visible indication of current laser power

Nanostitch

• Insert graph of tensile strength of Nanostitch vs. Suture

•Results coming

•Insert table of Nanostitch vs handheld laser application to show increased consistency (lower standard deviation) for device

•Results coming

Why report volume in ft3?

Re-order based on importance or group by implicit logical categories

Cut “s” in “Costs”

NanoStitch

Cutting-edge nanoshell technology offers a new wave of biomedical research that can be directly applied to the clinical setting. While current methods of wound closure, such as sutures and liquid adhesives, encounter problems arising from scarring, cost, infection and inconvenience, current research has shown promising results for the implementation of nanoshells in the field of laser tissue welding1. A significant setback to current laser wound closure techniques is the large user variability. To address the pitfalls of previous wound closure techniques, Team Lazer has designed and built a prototype of an easily applicable device and a user-friendly program to address the concerns of safety and consistency arising from the variables of laser distance, angle, and motion along with the surface temperature of the skin.

1. Gobin AM, O'neal DP, Watkins DM, Halas NJ, Drezek RA, West JL. Near infrared laser-tissue welding using nanoshells as an exogenous absorber. Lasers Surg Med. 2005 Aug;37(2):123-9.

Special Thanks to:• Andre Gobin• Dr. Jennifer West, Rice University• Dr. Oden, Rice University• CBEN• Brown Foundation Teaching Grant

Introduction

Device Concept

A Nanoshell Assisted Laser Tissue Welding Device Team Lazer, Rice University

Presented by Karl Balsara, Marc Burrell, Mike Cordray and Sanjay Maniar

Temperature Sensor

Laser Mounting Bracket

Motor

DampenedArm

ProximitySensor

Prototype Requirements

• Easily Portable

• Costs < $1500

• Volume < 3ft³

• Sensing Distance: 2-10cm

• Depth of Laser Penetration: 2-3mm

• User-friendly computer interface

Safety Concerns Addressed

• Size of Wound: 2-5cm

• Maximum Safety

• Highly Consistent

• Highly Repeatable

Patient Safety

• Temperature monitoring prevents damage to skin

• Modulated laser intensity to prevent burns

• Reduced manipulation of wound Less opportunity for infection

• Motorized angle adjustment allows for consistent application to skin

User Safety

• User interface alarms operator when critical temperature is reached

• Proximity to skin determined in real-time

• Automatic Shut-off System

Technical Specifications

Laser• FAP I Laser System made by Coherent Inc.,• Output: 14 W/cm²• Spot Size: 5 mm spot size

Solder Solution• Gold nanoshells peak absorbance of 821 nm • Nanoshell suspension of 7x1010 particles/ml

Temperature Sensor• Raytek MI Series• System response time of 150 ms

Proximity Sensor• Banner U-Gage S18U Analog Sensor• Measures distance between 3cm – 30cm

Software• Built in LABVIEW, easily upgradable • Easy to use Interface

Conclusions

• Current methods of wound closure are inconvenient and increase patient’s susceptibility to infection and scarring

• Incorporation of distance and temperature sensors into a user-friendly software program results in a safer and more consistent wound closure

Safe and Effective Solution

Acknowledgments and References

User Interface

• Visible alarms

• Temperature at wound and distance to wound highly visible

• Emergency stop button to cut laser power

• Easy calibration to ensure consistency between trials

• Visible indication of current laser power

Nanostitch

• Insert graph of tensile strength of Nanostitch vs. Suture

•Results coming

•Insert table of Nanostitch vs handheld laser application to show increased consistency (lower standard deviation) for device

•Results coming

Don’t justify line spacing because it creates odd spaces between words.

Lower case “s”

NanoStitch

Cutting-edge nanoshell technology offers a new wave of biomedical research that can be directly applied to the clinical setting. While current methods of wound closure, such as sutures and liquid adhesives, encounter problems arising from scarring, cost, infection and inconvenience, current research has shown promising results for the implementation of nanoshells in the field of laser tissue welding1. A significant setback to current laser wound closure techniques is the large user variability. To address the pitfalls of previous wound closure techniques, Team Lazer has designed and built a prototype of an easily applicable device and a user-friendly program to address the concerns of safety and consistency arising from the variables of laser distance, angle, and motion along with the surface temperature of the skin.

1. Gobin AM, O'neal DP, Watkins DM, Halas NJ, Drezek RA, West JL. Near infrared laser-tissue welding using nanoshells as an exogenous absorber. Lasers Surg Med. 2005 Aug;37(2):123-9.

Special Thanks to:• Andre Gobin• Dr. Jennifer West, Rice University• Dr. Oden, Rice University• CBEN• Brown Foundation Teaching Grant

Introduction

Device Concept

A Nanoshell Assisted Laser Tissue Welding Device Team Lazer, Rice University

Presented by Karl Balsara, Marc Burrell, Mike Cordray and Sanjay Maniar

Temperature Sensor

Laser Mounting Bracket

Motor

DampenedArm

ProximitySensor

Prototype Requirements

• Easily Portable

• Costs < $1500

• Volume < 3ft³

• Sensing Distance: 2-10cm

• Depth of Laser Penetration: 2-3mm

• User-friendly computer interface

Safety Concerns Addressed

• Size of Wound: 2-5cm

• Maximum Safety

• Highly Consistent

• Highly Repeatable

Patient Safety

• Temperature monitoring prevents damage to skin

• Modulated laser intensity to prevent burns

• Reduced manipulation of wound Less opportunity for infection

• Motorized angle adjustment allows for consistent application to skin

User Safety

• User interface alarms operator when critical temperature is reached

• Proximity to skin determined in real-time

• Automatic Shut-off System

Technical Specifications

Laser• FAP I Laser System made by Coherent Inc.,• Output: 14 W/cm²• Spot Size: 5 mm spot size

Solder Solution• Gold nanoshells peak absorbance of 821 nm • Nanoshell suspension of 7x1010 particles/ml

Temperature Sensor• Raytek MI Series• System response time of 150 ms

Proximity Sensor• Banner U-Gage S18U Analog Sensor• Measures distance between 3cm – 30cm

Software• Built in LABVIEW, easily upgradable • Easy to use Interface

Conclusions

• Current methods of wound closure are inconvenient and increase patient’s susceptibility to infection and scarring

• Incorporation of distance and temperature sensors into a user-friendly software program results in a safer and more consistent wound closure

Safe and Effective Solution

Acknowledgments and References

User Interface

• Visible alarms

• Temperature at wound and distance to wound highly visible

• Emergency stop button to cut laser power

• Easy calibration to ensure consistency between trials

• Visible indication of current laser power

Nanostitch

• Insert graph of tensile strength of Nanostitch vs. Suture

•Results coming

•Insert table of Nanostitch vs handheld laser application to show increased consistency (lower standard deviation) for device

•Results coming

Nice large image to highlight design, but replace with image of device put together. Use callouts for key components.

Serif fontExplain how it works.

NanoStitch

Cutting-edge nanoshell technology offers a new wave of biomedical research that can be directly applied to the clinical setting. While current methods of wound closure, such as sutures and liquid adhesives, encounter problems arising from scarring, cost, infection and inconvenience, current research has shown promising results for the implementation of nanoshells in the field of laser tissue welding1. A significant setback to current laser wound closure techniques is the large user variability. To address the pitfalls of previous wound closure techniques, Team Lazer has designed and built a prototype of an easily applicable device and a user-friendly program to address the concerns of safety and consistency arising from the variables of laser distance, angle, and motion along with the surface temperature of the skin.

1. Gobin AM, O'neal DP, Watkins DM, Halas NJ, Drezek RA, West JL. Near infrared laser-tissue welding using nanoshells as an exogenous absorber. Lasers Surg Med. 2005 Aug;37(2):123-9.

Special Thanks to:• Andre Gobin• Dr. Jennifer West, Rice University• Dr. Oden, Rice University• CBEN• Brown Foundation Teaching Grant

Introduction

Device Concept

A Nanoshell Assisted Laser Tissue Welding Device Team Lazer, Rice University

Presented by Karl Balsara, Marc Burrell, Mike Cordray and Sanjay Maniar

Temperature Sensor

Laser Mounting Bracket

Motor

DampenedArm

ProximitySensor

Prototype Requirements

• Easily Portable

• Costs < $1500

• Volume < 3ft³

• Sensing Distance: 2-10cm

• Depth of Laser Penetration: 2-3mm

• User-friendly computer interface

Safety Concerns Addressed

• Size of Wound: 2-5cm

• Maximum Safety

• Highly Consistent

• Highly Repeatable

Patient Safety

• Temperature monitoring prevents damage to skin

• Modulated laser intensity to prevent burns

• Reduced manipulation of wound Less opportunity for infection

• Motorized angle adjustment allows for consistent application to skin

User Safety

• User interface alarms operator when critical temperature is reached

• Proximity to skin determined in real-time

• Automatic Shut-off System

Technical Specifications

Laser• FAP I Laser System made by Coherent Inc.,• Output: 14 W/cm²• Spot Size: 5 mm spot size

Solder Solution• Gold nanoshells peak absorbance of 821 nm • Nanoshell suspension of 7x1010 particles/ml

Temperature Sensor• Raytek MI Series• System response time of 150 ms

Proximity Sensor• Banner U-Gage S18U Analog Sensor• Measures distance between 3cm – 30cm

Software• Built in LABVIEW, easily upgradable • Easy to use Interface

Conclusions

• Current methods of wound closure are inconvenient and increase patient’s susceptibility to infection and scarring

• Incorporation of distance and temperature sensors into a user-friendly software program results in a safer and more consistent wound closure

Safe and Effective Solution

Acknowledgments and References

User Interface

• Visible alarms

• Temperature at wound and distance to wound highly visible

• Emergency stop button to cut laser power

• Easy calibration to ensure consistency between trials

• Visible indication of current laser power

Nanostitch

• Insert graph of tensile strength of Nanostitch vs. Suture

•Results coming

•Insert table of Nanostitch vs handheld laser application to show increased consistency (lower standard deviation) for device

•Results coming

Use one font consistently.

What’s the purpose of this section? The text bullets seem to explain the obvious.

NanoStitch

Cutting-edge nanoshell technology offers a new wave of biomedical research that can be directly applied to the clinical setting. While current methods of wound closure, such as sutures and liquid adhesives, encounter problems arising from scarring, cost, infection and inconvenience, current research has shown promising results for the implementation of nanoshells in the field of laser tissue welding1. A significant setback to current laser wound closure techniques is the large user variability. To address the pitfalls of previous wound closure techniques, Team Lazer has designed and built a prototype of an easily applicable device and a user-friendly program to address the concerns of safety and consistency arising from the variables of laser distance, angle, and motion along with the surface temperature of the skin.

1. Gobin AM, O'neal DP, Watkins DM, Halas NJ, Drezek RA, West JL. Near infrared laser-tissue welding using nanoshells as an exogenous absorber. Lasers Surg Med. 2005 Aug;37(2):123-9.

Special Thanks to:• Andre Gobin• Dr. Jennifer West, Rice University• Dr. Oden, Rice University• CBEN• Brown Foundation Teaching Grant

Introduction

Device Concept

A Nanoshell Assisted Laser Tissue Welding Device Team Lazer, Rice University

Presented by Karl Balsara, Marc Burrell, Mike Cordray and Sanjay Maniar

Temperature Sensor

Laser Mounting Bracket

Motor

DampenedArm

ProximitySensor

Prototype Requirements

• Easily Portable

• Costs < $1500

• Volume < 3ft³

• Sensing Distance: 2-10cm

• Depth of Laser Penetration: 2-3mm

• User-friendly computer interface

Safety Concerns Addressed

• Size of Wound: 2-5cm

• Maximum Safety

• Highly Consistent

• Highly Repeatable

Patient Safety

• Temperature monitoring prevents damage to skin

• Modulated laser intensity to prevent burns

• Reduced manipulation of wound Less opportunity for infection

• Motorized angle adjustment allows for consistent application to skin

User Safety

• User interface alarms operator when critical temperature is reached

• Proximity to skin determined in real-time

• Automatic Shut-off System

Technical Specifications

Laser• FAP I Laser System made by Coherent Inc.,• Output: 14 W/cm²• Spot Size: 5 mm spot size

Solder Solution• Gold nanoshells peak absorbance of 821 nm • Nanoshell suspension of 7x1010 particles/ml

Temperature Sensor• Raytek MI Series• System response time of 150 ms

Proximity Sensor• Banner U-Gage S18U Analog Sensor• Measures distance between 3cm – 30cm

Software• Built in LABVIEW, easily upgradable • Easy to use Interface

Conclusions

• Current methods of wound closure are inconvenient and increase patient’s susceptibility to infection and scarring

• Incorporation of distance and temperature sensors into a user-friendly software program results in a safer and more consistent wound closure

Safe and Effective Solution

Acknowledgments and References

User Interface

• Visible alarms

• Temperature at wound and distance to wound highly visible

• Emergency stop button to cut laser power

• Easy calibration to ensure consistency between trials

• Visible indication of current laser power

Nanostitch

• Insert graph of tensile strength of Nanostitch vs. Suture

•Results coming

•Insert table of Nanostitch vs handheld laser application to show increased consistency (lower standard deviation) for device

•Results coming

Need to describe testing.

NanoStitch

Cutting-edge nanoshell technology offers a new wave of biomedical research that can be directly applied to the clinical setting. While current methods of wound closure, such as sutures and liquid adhesives, encounter problems arising from scarring, cost, infection and inconvenience, current research has shown promising results for the implementation of nanoshells in the field of laser tissue welding1. A significant setback to current laser wound closure techniques is the large user variability. To address the pitfalls of previous wound closure techniques, Team Lazer has designed and built a prototype of an easily applicable device and a user-friendly program to address the concerns of safety and consistency arising from the variables of laser distance, angle, and motion along with the surface temperature of the skin.

1. Gobin AM, O'neal DP, Watkins DM, Halas NJ, Drezek RA, West JL. Near infrared laser-tissue welding using nanoshells as an exogenous absorber. Lasers Surg Med. 2005 Aug;37(2):123-9.

Special Thanks to:• Andre Gobin• Dr. Jennifer West, Rice University• Dr. Oden, Rice University• CBEN• Brown Foundation Teaching Grant

Introduction

Device Concept

A Nanoshell Assisted Laser Tissue Welding Device Team Lazer, Rice University

Presented by Karl Balsara, Marc Burrell, Mike Cordray and Sanjay Maniar

Temperature Sensor

Laser Mounting Bracket

Motor

DampenedArm

ProximitySensor

Prototype Requirements

• Easily Portable

• Costs < $1500

• Volume < 3ft³

• Sensing Distance: 2-10cm

• Depth of Laser Penetration: 2-3mm

• User-friendly computer interface

Safety Concerns Addressed

• Size of Wound: 2-5cm

• Maximum Safety

• Highly Consistent

• Highly Repeatable

Patient Safety

• Temperature monitoring prevents damage to skin

• Modulated laser intensity to prevent burns

• Reduced manipulation of wound Less opportunity for infection

• Motorized angle adjustment allows for consistent application to skin

User Safety

• User interface alarms operator when critical temperature is reached

• Proximity to skin determined in real-time

• Automatic Shut-off System

Technical Specifications

Laser• FAP I Laser System made by Coherent Inc.,• Output: 14 W/cm²• Spot Size: 5 mm spot size

Solder Solution• Gold nanoshells peak absorbance of 821 nm • Nanoshell suspension of 7x1010 particles/ml

Temperature Sensor• Raytek MI Series• System response time of 150 ms

Proximity Sensor• Banner U-Gage S18U Analog Sensor• Measures distance between 3cm – 30cm

Software• Built in LABVIEW, easily upgradable • Easy to use Interface

Conclusions

• Current methods of wound closure are inconvenient and increase patient’s susceptibility to infection and scarring

• Incorporation of distance and temperature sensors into a user-friendly software program results in a safer and more consistent wound closure

Safe and Effective Solution

Acknowledgments and References

User Interface

• Visible alarms

• Temperature at wound and distance to wound highly visible

• Emergency stop button to cut laser power

• Easy calibration to ensure consistency between trials

• Visible indication of current laser power

Nanostitch

• Insert graph of tensile strength of Nanostitch vs. Suture

•Results coming

•Insert table of Nanostitch vs handheld laser application to show increased consistency (lower standard deviation) for device

•Results coming

What’s this?

Need to report results in more detail.

NanoStitch

Cutting-edge nanoshell technology offers a new wave of biomedical research that can be directly applied to the clinical setting. While current methods of wound closure, such as sutures and liquid adhesives, encounter problems arising from scarring, cost, infection and inconvenience, current research has shown promising results for the implementation of nanoshells in the field of laser tissue welding1. A significant setback to current laser wound closure techniques is the large user variability. To address the pitfalls of previous wound closure techniques, Team Lazer has designed and built a prototype of an easily applicable device and a user-friendly program to address the concerns of safety and consistency arising from the variables of laser distance, angle, and motion along with the surface temperature of the skin.

1. Gobin AM, O'neal DP, Watkins DM, Halas NJ, Drezek RA, West JL. Near infrared laser-tissue welding using nanoshells as an exogenous absorber. Lasers Surg Med. 2005 Aug;37(2):123-9.

Special Thanks to:• Andre Gobin• Dr. Jennifer West, Rice University• Dr. Oden, Rice University• CBEN• Brown Foundation Teaching Grant

Introduction

Device Concept

A Nanoshell Assisted Laser Tissue Welding Device Team Lazer, Rice University

Presented by Karl Balsara, Marc Burrell, Mike Cordray and Sanjay Maniar

Temperature Sensor

Laser Mounting Bracket

Motor

DampenedArm

ProximitySensor

Prototype Requirements

• Easily Portable

• Costs < $1500

• Volume < 3ft³

• Sensing Distance: 2-10cm

• Depth of Laser Penetration: 2-3mm

• User-friendly computer interface

Safety Concerns Addressed

• Size of Wound: 2-5cm

• Maximum Safety

• Highly Consistent

• Highly Repeatable

Patient Safety

• Temperature monitoring prevents damage to skin

• Modulated laser intensity to prevent burns

• Reduced manipulation of wound Less opportunity for infection

• Motorized angle adjustment allows for consistent application to skin

User Safety

• User interface alarms operator when critical temperature is reached

• Proximity to skin determined in real-time

• Automatic Shut-off System

Technical Specifications

Laser• FAP I Laser System made by Coherent Inc.,• Output: 14 W/cm²• Spot Size: 5 mm spot size

Solder Solution• Gold nanoshells peak absorbance of 821 nm • Nanoshell suspension of 7x1010 particles/ml

Temperature Sensor• Raytek MI Series• System response time of 150 ms

Proximity Sensor• Banner U-Gage S18U Analog Sensor• Measures distance between 3cm – 30cm

Software• Built in LABVIEW, easily upgradable • Easy to use Interface

Conclusions

• Current methods of wound closure are inconvenient and increase patient’s susceptibility to infection and scarring

• Incorporation of distance and temperature sensors into a user-friendly software program results in a safer and more consistent wound closure

Safe and Effective Solution

Acknowledgments and References

User Interface

• Visible alarms

• Temperature at wound and distance to wound highly visible

• Emergency stop button to cut laser power

• Easy calibration to ensure consistency between trials

• Visible indication of current laser power

Nanostitch

• Insert graph of tensile strength of Nanostitch vs. Suture

•Results coming

•Insert table of Nanostitch vs handheld laser application to show increased consistency (lower standard deviation) for device

•Results coming

These aren’t conclusions. Focus on your design’s features and advantages

NanoStitch

Cutting-edge nanoshell technology offers a new wave of biomedical research that can be directly applied to the clinical setting. While current methods of wound closure, such as sutures and liquid adhesives, encounter problems arising from scarring, cost, infection and inconvenience, current research has shown promising results for the implementation of nanoshells in the field of laser tissue welding1. A significant setback to current laser wound closure techniques is the large user variability. To address the pitfalls of previous wound closure techniques, Team Lazer has designed and built a prototype of an easily applicable device and a user-friendly program to address the concerns of safety and consistency arising from the variables of laser distance, angle, and motion along with the surface temperature of the skin.

1. Gobin AM, O'neal DP, Watkins DM, Halas NJ, Drezek RA, West JL. Near infrared laser-tissue welding using nanoshells as an exogenous absorber. Lasers Surg Med. 2005 Aug;37(2):123-9.

Special Thanks to:• Andre Gobin• Dr. Jennifer West, Rice University• Dr. Oden, Rice University• CBEN• Brown Foundation Teaching Grant

Introduction

Device Concept

A Nanoshell Assisted Laser Tissue Welding Device Team Lazer, Rice University

Presented by Karl Balsara, Marc Burrell, Mike Cordray and Sanjay Maniar

Temperature Sensor

Laser Mounting Bracket

Motor

DampenedArm

ProximitySensor

Prototype Requirements

• Easily Portable

• Costs < $1500

• Volume < 3ft³

• Sensing Distance: 2-10cm

• Depth of Laser Penetration: 2-3mm

• User-friendly computer interface

Safety Concerns Addressed

• Size of Wound: 2-5cm

• Maximum Safety

• Highly Consistent

• Highly Repeatable

Patient Safety

• Temperature monitoring prevents damage to skin

• Modulated laser intensity to prevent burns

• Reduced manipulation of wound Less opportunity for infection

• Motorized angle adjustment allows for consistent application to skin

User Safety

• User interface alarms operator when critical temperature is reached

• Proximity to skin determined in real-time

• Automatic Shut-off System

Technical Specifications

Laser• FAP I Laser System made by Coherent Inc.,• Output: 14 W/cm²• Spot Size: 5 mm spot size

Solder Solution• Gold nanoshells peak absorbance of 821 nm • Nanoshell suspension of 7x1010 particles/ml

Temperature Sensor• Raytek MI Series• System response time of 150 ms

Proximity Sensor• Banner U-Gage S18U Analog Sensor• Measures distance between 3cm – 30cm

Software• Built in LABVIEW, easily upgradable • Easy to use Interface

Conclusions

• Current methods of wound closure are inconvenient and increase patient’s susceptibility to infection and scarring

• Incorporation of distance and temperature sensors into a user-friendly software program results in a safer and more consistent wound closure

Safe and Effective Solution

Acknowledgments and References

User Interface

• Visible alarms

• Temperature at wound and distance to wound highly visible

• Emergency stop button to cut laser power

• Easy calibration to ensure consistency between trials

• Visible indication of current laser power

Nanostitch

• Insert graph of tensile strength of Nanostitch vs. Suture

•Results coming

•Insert table of Nanostitch vs handheld laser application to show increased consistency (lower standard deviation) for device

•Results coming

Use paragraph form to create more space above for testing and results.

Spell out CBEN. Italicize journals.

Capital “N”

Revised poster . . .

NanoStitch

Current methods of wound closure, such as sutures and liquid adhesives, lead to increased scarring, cost, inconvenience, and possibility for infection. A new approach that combines nanoshell technology with laser tissue welding1 appears promising. However, the problem of user variability remains to be solved. Team Lazer has designed and built a prototype of an easily applicable device and a user-friendly software to address the concerns of safety and consistency arising from the variables of laser distance, angle, and motion along with the surface temperature of the skin.

1. Gobin AM, O'neal DP, Watkins DM, Halas NJ, Drezek RA, West JL. Near infrared laser-tissue welding using nanoshells as an exogenous absorber. Lasers Surg Med. 2005 Aug;37(2):123-9.

Special Thanks:Team Lazer would like to thank Andre Gobin, Dr. Jennifer West, Dr. Maria Oden, Joseph Gesenhues, the Center for Biological and Environmental Nanotechnology and the Brown Foundation Teaching Grant for all of their help and support throughout the entire design process.

Introduction

NanoStitch Concept

A Nanoshell Assisted Laser Tissue Welding System Team Lazer, Department of Bioengineering, Rice University

Presented by Karl Balsara, Marc Burrell, Mike Cordray and Sanjay Maniarteamlazer@gmail.com

Prototype Requirements

• Easily Portable

• Maximum Safety

• Cost < $5 per use

• Cost < $1500 per device

• Operable with minimal training

• Highly Consistent & Repeatable

• Operator friendly computer interface

Safety Concerns Addressed

• Size of Wound: 2-5cm

• Volume < 2m³

• Sensing Distance: 2-10cm

Patient Safety

•Temperature monitoring prevents damage to skin

•Modulated laser intensity to prevent burns

•Reduced manipulation of wound Less opportunity for infection

•Motorized angle adjustment allows for consistent application to skin

Operator Safety

•Alarms when critical temperature is reached

•Proximity to skin determined in real-time

•Automatic Shut-off system

Conclusions

• NanoStitch goes one step further than conventional hand-held laser tissue welding technology.

• The incorporation of real-time feedback controlled distance and temperature sensors into a user-friendly software program results in a safer and more consistent wound closure.

Safe and Effective Solution

Acknowledgments and References

NanoStitch User Interface

Method of Wound Closure

Young's Modulus Yield Point Ultimate Tensile Stress

NanoStitch (n=5)0.044 ± 0.009

N/mm²0.019± 0.027

N/mm²0.013 ± 0.0038

N/mm²

Handheld (n=5)0.028 ± 0.016

N/mm² 0.013± 0.022

N/mm²0.008 ± 0.0055

N/mm²

Suture (n=5)0.030 ± 0.016

N/mm²0.012 ± 0.006

N/mm²0.015 ± 0.011

N/mm²

• Mechanical tensile failure tests were implemented to determine efficacy of NanoStitch • No significant difference between tensile strength of NanoStitch and Suturing Technique (two-sample t-test, <0.05)

• NanoStitch exhibits significantly greater Young’s Modulus over Handheld technique (two-sample t-test, <0.05)

• Qualitative analysis illustrate more frequent failure at grip site, rather than welding site, during NanoStitch testing

Set Up

• Laser adjusted to desired conditions

• Distance and temperature sensor calibrated

Sample Preparation

• Chicken samples isolated

• Nanoshell solder applied directly to wound

Commence Annealing Process

• Laser shined over wound to begin closure

• Motor adjusts angle of laser to maintain surface

exposure

Safety Feedback Mechanisms

• If temperature becomes too high, alarms trigger

operator and laser intensity ramped down

• Operator notified of distance to wound in real-time to

ensure consistency

Safe, Successful Wound Closure!!

How it Works

NanoStitch

Current methods of wound closure, such as sutures and liquid adhesives, lead to increased scarring, cost, inconvenience, and possibility for infection. A new approach that combines nanoshell technology with laser tissue welding1 appears promising. However, the problem of user variability remains to be solved. Team Lazer has designed and built a prototype of an easily applicable device and a user-friendly software to address the concerns of safety and consistency arising from the variables of laser distance, angle, and motion along with the surface temperature of the skin.

1. Gobin AM, O'neal DP, Watkins DM, Halas NJ, Drezek RA, West JL. Near infrared laser-tissue welding using nanoshells as an exogenous absorber. Lasers Surg Med. 2005 Aug;37(2):123-9.

Special Thanks:Team Lazer would like to thank Andre Gobin, Dr. Jennifer West, Dr. Maria Oden, Joseph Gesenhues, the Center for Biological and Environmental Nanotechnology and the Brown Foundation Teaching Grant for all of their help and support throughout the entire design process.

Introduction

NanoStitch Concept

A Nanoshell Assisted Laser Tissue Welding System Team Lazer, Department of Bioengineering, Rice University

Presented by Karl Balsara, Marc Burrell, Mike Cordray and Sanjay Maniarteamlazer@gmail.com

Prototype Requirements

• Easily Portable

• Maximum Safety

• Cost < $5 per use

• Cost < $1500 per device

• Operable with minimal training

• Highly Consistent & Repeatable

• Operator friendly computer interface

Safety Concerns Addressed

• Size of Wound: 2-5cm

• Volume < 2m³

• Sensing Distance: 2-10cm

Patient Safety

•Temperature monitoring prevents damage to skin

•Modulated laser intensity to prevent burns

•Reduced manipulation of wound Less opportunity for infection

•Motorized angle adjustment allows for consistent application to skin

Operator Safety

•Alarms when critical temperature is reached

•Proximity to skin determined in real-time

•Automatic Shut-off system

Conclusions

• NanoStitch goes one step further than conventional hand-held laser tissue welding technology.

• The incorporation of real-time feedback controlled distance and temperature sensors into a user-friendly software program results in a safer and more consistent wound closure.

Safe and Effective Solution

Acknowledgments and References

NanoStitch User Interface

Method of Wound Closure

Young's Modulus Yield Point Ultimate Tensile Stress

NanoStitch (n=5)0.044 ± 0.009

N/mm²0.019± 0.027

N/mm²0.013 ± 0.0038

N/mm²

Handheld (n=5)0.028 ± 0.016

N/mm² 0.013± 0.022

N/mm²0.008 ± 0.0055

N/mm²

Suture (n=5)0.030 ± 0.016

N/mm²0.012 ± 0.006

N/mm²0.015 ± 0.011

N/mm²

• Mechanical tensile failure tests were implemented to determine efficacy of NanoStitch • No significant difference between tensile strength of NanoStitch and Suturing Technique (two-sample t-test, <0.05)

• NanoStitch exhibits significantly greater Young’s Modulus over Handheld technique (two-sample t-test, <0.05)

• Qualitative analysis illustrate more frequent failure at grip site, rather than welding site, during NanoStitch testing

Set Up

• Laser adjusted to desired conditions

• Distance and temperature sensor calibrated

Sample Preparation

• Chicken samples isolated

• Nanoshell solder applied directly to wound

Commence Annealing Process

• Laser shined over wound to begin closure

• Motor adjusts angle of laser to maintain surface

exposure

Safety Feedback Mechanisms

• If temperature becomes too high, alarms trigger

operator and laser intensity ramped down

• Operator notified of distance to wound in real-time to

ensure consistency

Safe, Successful Wound Closure!!

How it Works

Overall, revised poster contains an appropriate balance of text and visuals.

Excellent use of images, text boxes, and arrows to represent the device and how it works. Use of red/blue in this section provides additional coherence.

Layout is accessible.

Material is comprehensible. Formatting is consistent.