poster presentation 1 - convention.co.jp filethe 28th annual meeting of the international society...

The 28th Annual Meeting of the International Society for Heart Research Japanese Section

December 2nd (Fri) 17：10～17：50 Room 201＋202＋203

Poster Presentation 1

Cardiac hypertrophy 1

Chairperson： Hiroyuki Takano (Chiba University)

P 1-1 Activation of calmodulin kinase is a mechanism of reactive oxygen species

increase in diabetic heart Yasushi Teshima, Satoru Nishio, Naohiko Takahashi, Luong Cong Thuc, Akira Fukui, Osamu Kume, Kaori Ezaki, Hiroko Miyazaki, Kunio Yufu, Mikiko Nakagawa, Tetsunori Saikawa (Department of Laboratory Examination and Diagnostics, Oita University)

P 1-2 Natural killer T cells play a protective role in the development of cardiac

hypertrophy and heart failure after pressure overload in mice Masashige Takahashi1, Shintaro Kinugawa1, Tomoyasu Kadoguchi1, Shingo Takada1, Yoshihiro Masaki1, Arata Fukushima1, Tsuneaki Homma1, Tadashi Suga1, Taisuke Ono1, Mochamad Ali Sobirin2, Hiroyuki Tsutsui1

(1Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, 2Faculty of Medicine, Diponegoro University, Semarang-Indonesia)

P 1-3 Chemical Endoplasmic Reticulum Chaperone Alleviates Doxorubicin-induced

Cardiotoxicity and Cardiac Failure Hai Ying Fu, Tetsuo Minamino, Shoji Sanada, Issei Komuro (Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine)





Chairperson： Koji Hasegawa (National Hospital Organization Kyoto Medical Center)

P 2-1 Receptor for Activated Protein Kinase C1 is a novel component of p300/GATA4

complex and required for hypertrophic responses in cardiac myocytes Hidetoshi Suzuki1, Yoichi Sunagawa2, Yasufumi Katanasaka1, Nobuko Okamura1, Taishi Terada1, Masatoshi Namiki1, Yukiko Nakagawa1, Akihisa Sugimoto1, Hiromichi Wada3, Akira Shimatsu3, Takeshi Kimura4, Masatoshi Fujita5, Koji Hasegawa3, Tatsuya Morimoto1 (1Division of Molecular Medicine, School of Pharmaceutical Sciences, University of Shizuoka, 2Division of Molecular Medicine, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan and Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan, 3Division of Translational Research, Kyoto Medical Center, National Hospital Organization, Kyoto, Japan, 4Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan, 5Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan)

P 2-2 Transducin beta-like protein 1 suppresses p300/GATA4-induced hypertrophic

responses in cardiomyocytes Masatoshi Namiki1, Yasufumi Katanasaka1, Yoichi Sunagawa2, Hidetoshi Suzuki1, Sho Hirota1, Taishi Terada1, Yukiko Nakagawa1, Hiromichi Wada3, Akira Shimatsu3, Masatoshi Fujita2, Koji Hasegawa3, Tatsuya Morimoto1 (1Division of Molecular Medicine, University of Shizuoka, 2Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan, 3Division of Translational Research, Kyoto Medical Center, Kyoto, Japan)

P 2-3 Inhibition of I-kappaB Phosphorylation Prevents Load-induced Cardiac

Dysfunction in Mice Tetsu Tanaka1, Jun-ichi Suzuki2, Masahito Ogawa2, Asuka Yoshida3, Yasunobu Hirata2, Ryozo Nagai4, Mitsuaki Isobe1 (Departments of Cardiovascular Medicine, Tokyo Medical and Dental University, 2Departments of Advanced Clinical Science and Therapeutics, the University of Tokyo, 3Departments of Periodontology, Tokyo Medical and Dental University, 4Departments of Cardiovascular Medicine, the University of Tokyo)




Cardiac remodeling 1

Chairperson： Tomomi Ide (Kyushu University)

P 3-1 Circulating TNNI3K levels as a new diagnosis biomarker for acute myocardial

infarction, its background, current situation and perspectives Zhong-Fang Lai (Department of Pharmacology and Molecular Therapeutics, Graduate School of Medical Sciences, Kumamoto University)

P 3-2 L-carnitine Supplementation Prevents Cardiac Fibrosis and Heart Failure with

Preserved Ejection Fraction by Promoting Cardiac Prostacyclin Production Yosuke Omori1, Yasushi Sakata1, Tomohito Ohtani1, Yasuharu Takeda1, Shunsuke Tamaki1, Daisuke Kamimura1, Yasumasa Tsukamoto1, Yukitoshi Ikeya1, Tomoyoshi Soga2, Kazuhiro Yamamoto3, Toshiaki Mano1, Issei Komuro1 (1Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, 2Institute for Advanced Biosciences, Keio University, Tsuruoka, Japan, 3Division of Molecular Medicine and Therapeutics, Tottori University Faculty of Medicine, Yonago, Japan)

P 3-3 Cardiac-specific overexpression of phosphoglycerate mutase, a glycolytic enzyme,

induces pro-inflammatory response and cardiac dysfunction in mice Junji Okuda1, Shinnichiro Niizuma1, Yasutaka Inuzuka1, Takao Kato1, Tsuneaki Kawashima1, Yodo Tamaki1, Akira Kawamoto1, Yohei Tanada1, Michiko Narazaki2, Tetsuya Matsuda2, Hiroshi Kondoh3, Toru Kita1, Takeshi Kimura1, Tetsuo Shioi1 (1Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, 2Department of Systems Science, Graduate School of Informatics, Kyoto University, Japan, 3Department of Geriatric Medicine, Graduate School of Medicine, Kyoto University, Japan)





Chairperson： Yasuchika Takeishi (Fukushima Medical University)

P 4-1 Involvement of lipid binding protein in the modulation of parasympathetic

receptor signaling in atria Hiroko Maruyama, Masanori Ito, Hiroko Izumi-Nakaseko, Atsushi Sugiyama, Satomi Adachi-Akahane (Department of Pharmacology, Toho University/School of Medicine)

P 4-2 Gene delivery of suppressor of cytokine signaling 1 (SOCS1) inhibits myocardial

inflammation in experimental autoimmune myocarditis Kazuko Tajiri1, Kyoko Imanaka-Yoshida2, Michiaki Hiroe3, Tetsuji Naka4, Kazutaka Aonuma1, Yasuhiro Yasutomi5 (1Department of Cardiovascular Medicine, Majors of Medical Schiences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 2Department of Pathology and Matrix Biology, Mie University Graduate School of Medicine , Japan, 3Department of Cardiology, National Center of Global Health and Medicine, Japan, 4Laboratory of Immune Signal, National Institution of Biomedical Innovation, Japan, 5Laboratory of Immunoregulation and Vaccine Research, Tsukuba Primate Research Center, National Institution of Biomedical Innovation, Japan)

P 4-3 Macrolide Antibiotics Attenuate Ventricular Contraction Failure after Ischemia,

Myocarditis and Transplant Rejection Jun-ichi Suzuki1, Masahito Ogawa1, Yasunobu Hirata1, Ryozo Nagai2, Mitsuaki Isobe3 (1Department of Advanced Clinical Science and Therapeutics, University of Tokyo, 2Department of Cardiovascular Medicine, University of Tokyo, 3Department of Cardiovascular Medicine, Tokyo Medical and Dental University)





Chairperson： Hideharu Hayashi (Hamamatsu University)

P 5-1 The Activation of Natural Killer T Cells Ameliorates Myocardial Ischemia

Reperfusion Injury in Mice Tsuneaki Homma, Shintaro Kinugawa, Masashige Takahashi, Mochamad Ali Sobirin, Takashi Yokota, Taisuke Ono, Arata Fukushima, Tadashi Suga, Shingo Takada, Yoshihiro Masaki, Tomoyasu Kadoguchi, Hiroyuki Tsutsui (Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine)

P 5-2 Periodontal pathogens, Aggregatibacter actinomycetemcomitans is one of the

factors of deterioration of myocardial infarction Tomoya Hanatani1, Jun-ichi Suzuki2, Masahito Ogawa2, Norio Aoyama1, Naho Kobayashi1, Norihiko Ashigaki1, Asuka Yoshida1, Yuichi Izumi1, Mituaki Isobe3 (1Section of Periodontology, Department of Hard Tissue Engineering, Graduate School Tokyo Medical and Dental University, 2Advanced Clinical Science and Therapeutics/ University of Tokyo, Japan, 3Cardiovascular/ Tokyo Medical and Dental University, Japan)

P 5-3 A Novel ex vivo Cardiac Insulin Resistance Model Using Differentiated H9c2 Cell

and Saturated Fatty Acids Mamoru Nobuhara, Masao Saotome, Tomoyuki Watanabe, Tsuyoshi Urushida, Hideki Katoh, Hiroshi Satoh, Hideharu Hayashi (Internal Medicine 3, Hamamatsu University School of Medicine)




Atherosclerosis 1

Chairperson： Masashi Arai (Gunma University)

P 6-1 16-week high intensity aerobic exercise may not be effective on obesity

Ho-dirk Kim, Loan Tran (Department of Anatomy Cardiovascular Research Unit, Sungkyunkwan University School of Medicine)

P 6-2 Atorvastatin Counteracts Thromboxane A2- induced, Rho kinase-Mediated

Endothelial Cell Damage via PI3 kinase-Akt Dependent Pathway Ryoji Yokota (Cardiovascular Center, Nara Hospital, Kinki University School of Medicine)

P 6-3 Novel selective NFκB inhibitor compound suppresses pulmonary arterial smooth

muscle cell proliferation for pulmonary arterial hypertension Susumu Hosokawa1, Go Haraguchi2, Akihito Sasaki1, Shozaburo Doi1, Mitsuaki Isobe3 (1Department of Pediatrics, Tokyo Medical and Dental University School of Medicine, 2Division of Intensive Care Unit, Tokyo Medical and Dental University School of Medicine, 3Department of Cardiovascular Medicine, Tokyo Medical and Dental University School of Medicine)




Clinical 1

Chairperson： Nobuakira Takeda (Jikei University School of Medicine)

P 7-1 Elevated ratio of placental growth factor to soluble fms-like tyrosine kinase-1

predicts an adverse outcome in patients with chronic coronary artery disease Takaki Matsumoto, Shiro Uemura, Masaru Matsui, Ayako Senoo, Yukiji Takeda, Kenji Onoue, Manabu Horii, Yoshihiko Saito (First Department of Internal Medicine, Nara Medical University, 840 Shijo-cho, Kashihara city, Nara, Japan)

P 7-2 The Association of Circulating MicroRNAs with Prognosis of Patients after

Acute Myocardial Infarction Sen Matsumoto, Yasuhiko Sakata, Issei Komuro (Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine)

P 7-3 No Evidence of Persistent Infection with Hepatitis C Virus in the Myocardium of

Patients with End-stage Idiopathic Dilated Cardiomyopathy Shigekazu Fujioka (Department of Rehabilitation Science, Osaka Health Science University)




Arrhythmia 1

Chairperson： Satomi Adachi-Akahane (Toho University)

P 8-1 Genetic deletion of transcription factor in cardiac conduction system mimicked

early repolarization syndrome in mouse Tetsuo Sasano1, Akiko Koizumi2, Wataru Kimura3, Naoyuki Miura3, Kenzo Hirao4, Mitsuaki Isobe1, Tetsushi Furukawa2

(1Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Japan, 2Bio-informational Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, Japan, 3Department of Biochemistry, Hamamatsu Medical College, Japan, 4Heart Rhythm Center, Tokyo Medical and Dental University, Japan)

P 8-2 NOS1AP Deletion Enhanced Ventricular Arrhythmogenicity and Cardiac Death

in Pressure Overloaded condition Tetsuo Sasano1, Kenzo Hirao2, Tadashi Okamura3, Norihiro Kato3, Mitsuaki Isobe1， Tetsushi Furukawa4 (1Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Japan, 2Heart Rhythm Center, Tokyo Medical and Dental University, Japan, 3Research Institute National Center for Global Health and Medicine, Japan, 4Department of Bio-informational Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, Japan)

P 8-3 Hyperthermia-induced Arrhythmias and Sudden Death in Mouse Model of

Dravet Syndrome Tetsuo Sasano1, Yumi Horigome2, Yukitoshi Takahashi2, Ikuo Ogiwara3, Mitsuaki Isobe1, Tetsushi Furukawa4 (1Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Japan, 2Shizuoka Institute of Epilepsy and Neurological Disorders, Japan 3Laboratories for Neurogenetics, RIKEN Brain Science Institute, Japan, 4Department of Bio-informational Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, Japan)


December 3rd (Sat) 15：40～16：30 Room 201＋202＋203



Chairperson： Hiroyuki Watanabe (Akita University)

P 9-1 Tolerance to pressure-overload in the left ventricle of STIM1 knockout mouse.

Takayoshi Ohba1, Hiroyuki Watanabe2, Kyoichi Ono1, Hiroshi Ito2 (1Department of Cell Physiology, Akita University Graduate School of Medicine, 2Department of Internal Medicine Division of Cardiovascular and Respiratory Medicine, Akita University Graduate School of Medicine, Japan)

P 9-2 Cardiac macrophages are essential for the myocardial protective response to

pressure overload Munehiko Shibata, Ichiro Manabe, Ryozo Nagai (Deparment of Cardiovascular Medicine, The University of Tokyo)

P 9-3 Endoplasmic reticulum stress induces cardiomyocyte apoptosis during

pathological cardiac hypertrophy through the p38 MAPK pathway Flori R. Sari1, Kenichi Watanabe1, Bambang Widyantoro2, Rajarajan A. Thandavarayan1, Meilei Harima1, Vijayakumar Sukumaran1, Vivian Soetikno1, Arun Prasath Lakshmanan1, Somasundaram Arumugam1, Shaosong Zhang3, Anthony J. Muslin4 (1Department of Clinical Pharmacology, Niigata University of Pharmacy and Applied LifeSciences, 2Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Japan, 3Lightlab Imaging, Inc., One Technology Park Drive, Westford, Massachusetts 01886, USA, 4Center for Cardiovascular Research, John Milliken Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA)





Chairperson： Kouichirou Kuwahara (Kyoto University)

P 10-1 Brain Inflammation mediated by AT1 Receptor-activated Toll-like Receptor 4

Causes Sympathoexcitation in Myocardial Infarction-induced Heart Failure Kiyohiro Ogawa, Yoshitaka Hirooka, Takuya Kishi, Kenji Sunagawa (Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences)

P 10-2 Changes in vascular properties, not ventricular properties, predominantly

contribute to baroreflex regulation of arterial pressure Takafumi Sakamoto, Yoshinori Murayama, Tomoyuki Tobushi, Kazuo Sakamoto, Atsushi Tanaka, Keita Saku, Kazuya Hosokawa, Ken Onizuka, Takeo Fujino, Kota Funakoshi, Kenji Sunagawa (Cardiovascular Medicine, Kyushu university graduate school of medical sciences)

P 10-3 Establishment of a Novel Murine Model of Ischemic Cardiomyopathy

Hajime Nakaoka1, Yumiko Nakagawa-Toyama2, Makoto Nishida2, Kazumi Tsubakio-Yamamoto1, Taiji Yamashita1, Kazuhiro Nakatani1, Ryota Kawase1, Daisaku Masuda1, Tohru Ohama2, Masato Ishigami3, Monty Kriger4, Shizuya Yamashita1, Issei Komuro1 (1Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, 2Health Care Center, Osaka University, Osaka, Japan, 3Division of Health Science, Osaka University Graduate School of Medicine, Osaka, Japan, 4Department of Biology, Massachusetts Institute of Technology, Boston, USA)

P 10-4 Senescence marker protein-30 deficiency impairs myocardium-induced dilation

in coronary arterioles associated with reactive oxygen species in aging Hiroyuki Mizukami, Shu-ichi Saitoh, Shinya Yamada, Hirofumi Machii, Hitoshi Suzuki, Yasuchika Takeishi (Department of Cardiology and Hematology, Fukushima Medical University)





Chairperson： Go Haraguchi (Tokyo Medical and Dental University)

P 11-1 The LV stiffness during underperfusion and reperfusion in diabetic rat hearts

with calcitonin gene-related peptide (CGRP) Makie Higuchi, Takamoto Akamine (Division of Pharmacology, Kyushu University of Nursing & Social Welfare)

P 11-2 The relationship between severity of heart failure and cardiomyocite function in

an inherited dilated cardiomyopathy mouse model Fuminori Odagiri1, Masami Sugihara1, Takeshi Suzuki1, Hiroyuki Daida1, Nagomi Kurebayashi2 (1Department of Pharmacology, Department of Cardiology, Juntendo University School of Medicine, 2Department of Pharmacology, Juntendo University School of Medicine)

P 11-3 Inhibition of IκB Phosphorylation by a Novel IKK Inhibitor IMD-1041

Attenuates Myocardial Dysfunction after Infarction Ryo Matsumoto1, Jun-ichi Suzuki2, Masahito Ogawa2, Tomoya Hanatani3, Yasunobu Hirata2, Ryozo Nagai3, Mitsuaki Isobe1

(1Departments of Cardiovascular Medicine, Tokyo Medical and Dental University, 2Departments of Advanced Clinical Science and Therapeutics, the University of Tokyo, 3Departments of Periodontology, Tokyo Medical and Dental University, 4Departments of Cardiovascular Medicine, the University of Tokyo)

P 11-4 An Comparison between Angiotensin Converting Enzyme Inhibitor and

Angiotensin Receptor II Blocker for the Suppresses Contrast Media Induced Renal Dysfunction in a Murine Model of Subtotal Nephrectomy Masahito Ogawa1, Jun-ichi Suzuki1, Yasunobu Hirata1, Ryozo Nagai2, Mitsuaki Isobe3

(1Departments of Advanced Clinical Science and Therapeutics, the University of Tokyo, 2Departments of Cardiovascular Medicine, the University of Tokyo, 3Department of Cardiovascular Medicine, Tokyo Medical and Dental University)





Chairperson： Ichiro Manabe (The University of Tokyo)

P 12-1 A Direct Renin Inhibitor Negates Ischemia-Induced Cardiac Remodeling with

Chronic Kidney Disease in Mice Masahito Ogawa1, Jun-ichi Suzuki1§, Yasunobu Hirata1, Ryozo Nagai2, Mitsuaki Isobe3

(1Departments of Advanced Clinical Science and Therapeutics, the University of Tokyo, 2Departments of Cardiovascular Medicine, the University of Tokyo, 3Department of Cardiovascular Medicine, Tokyo Medical and Dental University)

P 12-2 Switching of HIF-α isoforms is critical in the resolution of inflammation

Norihiko Takeda, Hajime Abe, Hiroaki Semba, Ichiro Manabe, Ryozo Nagai (Department of Cardiovascular Medicine, University of Tokyo)

P 12-3 The Essential Role of Transsulfuration Pathway in Fasting-induced

Cardioprotection against Ischemic/reperfusion Injury Ken Shinmura1, Kayoko Tamaki1, Shintaro Nakano2, Noriyuki Akaboshi2, Hidenori Yamada2, Motoaki Sano1, Makoto Suematsu2, Isao Ishii2 (1Department of Internal Medicine, Keio University School of Medicine, 2Department of Biochemistry and Integrative Medical biology, Keio University School of Medicine, Japan)

P 12-4 Dysregulation of the mitochondrial permeability transition pore by increased

UPRs in the ER and mitochondria underlies loss of protection in diabetic hearts. Takahito Itoh, Kouzu Hidemichi, Miki Takayuki, Tanno Masaya, Atsushi Kuno, Tatsuya Sato, Daisuke Sunaga, Satoko Ishikawa, Tetsuji Miura (Second Department of Internal Medicine, Sapporo Medical University School of Medicine)




Cardiac regeneration 1

Chairperson： Hiroshi Akazawa (Osaka University Graduate School of Medicine)

P 13-1 Br-DIF-1 accelerates 1% dimethyl sulfoxide-induced cardiomyocyte

differentiation of P19CL6 embryonic carcinoma cells Kazuhiko Seya1, Kouta Kanemaru1, Mizuho Matsuki2, Kyoko Hongo1, Haruo Kitahara2, Haruhisa Kikuchi3, Yoshiteru Oshima3, Yuzuru Kubohara4, Ken Okumura5, Shigeru Motomura1, Ken-Ichi Furukawa1 (1Department of Pharmacology, Hirosaki University Graduate School of Medicine, 2Faculty of Education, Hirosaki University, Japan, 3Graduate School of Pharmaceutical Sciences, Tohoku University, Japan, 4Department of Molecular and Cellular Biology, Institute for Molecular and Cellular Regulation, Gunma University, Japan, 5Department of Cardiology, Respiratory Medicine and Nephrology, Hirosaki University Graduate School of Medicine, Japan)

P 13-2 The combination therapy with myoblast sheet transplantation and novel peptide

WiDa for cardiac failure Ayako Uchinaka, Yoshinosuke Hamada, Naomasa Kawaguchi, Seiji Mori, Nariaki Matsuura (Department of Molecular pathology, Graduate School of Medicine and Health Sciences, Osaka University)

P 13-3 Role of Autophagy in Imatinib-Mediated Cardiac toxicity

Miyuki Kobara1, Kazuki Noda1, Jiahong Wang1, Hiroe Toba1, Eri Kanai2, Satoaki Matoba2, Hiroaki Matsubara2, Tetsuo Nakata1 (1Department of Clinical Pharmacology, Kyoto Pharmaceutical University, 2Department of Cardiovascular Medicine, Kyoto Prefectural University of Medicine, Japan)

P 13-4 Autoimplantation of Astrocyte into Cardiovascular Center of Brainstem Causes

Sympathoinhibition and Decreases the Mortality Rate in Myocardial Infarction-induced Heart Failure Takuya Kishi1, Yoshitaka Hirooka2, Kenji Sunagawa1 (1Department of Advanced Therapeutics for Cardiovascular Diseases, Kyushu University Graduate School of Medical Sciences, 2Department of Advanced Cardiovascular Regulation and Therapeutics, Kyushu University Graduate School of Medical Sciences, Japan)




Atherosclerosis 2

Chairperson： Toshihiro Ichiki (Kyushu University)

P 14-1 Artificial Baroreceptor System Restores Physiological Volume Buffering

Function in Pulmonary Edema Induced by Baroreflex Failure Kazuya Hosokawa, Kouta Funakoshi, Takafumi Sakamoto, Ken Onitsuka, Kazuo Sakamoto, Tomoyuki Tobushi, Takeo Fujino, Keita Saku, Masataka Ikeda, Takamori Kakino, Yoshinori Murayama, Tomomi Ide, Kenji Sunagawa (Department of cardiovascular medicine, Kyushu university graduate school of medical sciences)

P 14-2 Relationship between Periodontal Bacteria and Arterial Injury

Naho Kobayashi1, Jun-ichi Suzuki2, Masahito Ogawa2, Norio Aoyama1, Tomoya Hanatani1, Norihiko Ashigaki1, Asuka Yoshida1, Yuichi Izumi1, Mitsuaki Isobe3 (1Department of Periodontology, Tokyo Medical and Dental University, 2Department of Advanced Clinical Science and Therapeutic, the University of Tokyo, Japan, 3Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Japan)

P 14-3 Periodontal Pathogens Deteriorated Survival Rate after Subtotal Nephrectomy

in Mice. Norihiko Ashigaki1, Jun-ichi Suzuki2, Masahito Ogawa2, Norio Aoyama1, Naho Kobayashi1, Asuka Yoshida1, Ryo Watanabe3, Yuichi Izumi1, Mitsuaki Isobe3 (1Section of Periogineeringdontology, Department of Hard Tissue En, Graduate School Tokyo Medical and Dntal University, 2Advanced clinical science and therapeutics/University of Tokyo, Japan, 3Cardiovascular/Tokyo Medical and dental university, Japan)




Atherosclerosis 3

Chairperson： Takayuki Shindo (Shinshu University)

P 15-1 M1 Macrophages Have Characteristic Role in Atherogenesis: Transcriptional

analysis of human polarized macrophages in Oxidized Low-density Lipoprotein Uptake. Kuniaki Hirose1, Kazunori Shimada1, Takashi Kiyanagi1, Chihiro Iwahara2, Hitoshi Nakayama2, Kazuhisa Iwabuchi2, Hiroyuki Daida1 (1Department of Cardiovascular Medicine, Juntendo University School of Medicine, 2Institute for Environmental and Gender Specific Medicine, Juntendo University Graduate School of Medicine)

P 15-2 Endothelial Gab1 Deletion Accelerates Angiotensin II-Dependent Vascular

Inflammation and Atherosclerosis in ApoE Knockout Mice Yoshikazu Nakaoka1, Kaori Higuchi1, Wataru Shioyama1, Yoh Arita1, Takahiro Hasihmoto1, Tadashi Kuroda1, Yasushi Fujio1, Keiko Yamauchi-Takihara1, Mikikyasu Shirai2, Naoki Mochizuki3, Issei Komuro1 (1Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, 2Department of Cardiac Physiology, National Cerebral and Cardiovascular Center Research Institute, 3Department of Cell Biology, National Cerebral and Cardiovascular Center Research Institute)

P 15-3 A Novel IKK Inhibitor Prevents Neointimal Formation after Arterial Injury

Rikuta Hamaya1, Jun-ichi Suzuki2, Masahito Ogawa2, Naho Kobayashi3, Yasunobu Hirata2, Ryozo Nagai4, Mitsuaki Isobe1 (1Departments of Cardiovascular Medicine, Tokyo Medical and Dental University, 2Departments of Advanced Clinical Science and Therapeutics, the University of Tokyo, 3Departments of Periodontology, Tokyo Medical and Dental University, 4Departments of Cardiovascular Medicine, the University of Tokyo)

P 15-4 Can FDG-PET/CT Diagnose Cardiac Sarcoidosis? ―The role of new index, max

SUV gradient in myocardium with cardiac sarcoidosis― Daisuke Tezuka, Haraguchi Go, Hiroshi Ohigashi, Chisato Takamura, Masanori Konishi, Mitsuaki Isobe (Department of Cardiovascular Medicine, Tokyo Medical and Dental University)




Clinical 2

Chairperson： Makoto Kodama (Niigata University Graduate School of Medical & Dental Sciences)

P 16-1 Is the carotid intima-media thickness really a good surrogate of atherosclerosis ?

Ho-dirk Kim, Loan Tran (Department of Anatomy, Sungkyunkwan University School of Medicine CV Research Unit)

P 16-2 Status of blood pressure control in patients with flash pulmonary edema

Yukako Ohno, Masahiro Ito, Makoto Kodama, Takeshi Kashimura, Hiroaki Obata, Makoto Tomita, Haruo Hanawa, Yoshifusa Aizawa (First Department of Internal Medicine Niigata University Medical Hospital)

P 16-3 Aortic Stenosis Presenting As Flash Pulmonary Edema

Masataka Arita, Yukako Ohno, Makoto Tomita, Hiroaki Obata, Takeshi Kashimura, Masahiro Ito, Haruo Hanawa, Makoto Kodama (First Department of Internal Mecine, Niigata Unversity Medical Hospital)




Arrhythmia 2

Chairperson： Tetuo Sasano (Tokyo Medical and Dental University)

P 17-1 Eplerenone prevents connexin43 dispersion and mediates mRNA expression of

SERCA2a and KCNE1/KCNQ1 ratio, leading to the suppression of ventricular arrhythmias Kazuki Noda, Miyuki Kobara, Jiahong Wang, Hiroe Toba, Tetsuo Nakata (Department of Clinical Pharmacology, Kyoto Pharmaceutical University)

P 17-2 A lipid binding protein participates in the regulation of Ca2+ signaling through

modulation of L-type Ca2+ channel CaV1.2 function in atria. Hiroko Izumi-Nakaseko, Masanori Ito, Hiroko Maruyama, Atsushi Sugiyama, Satomi Adachi-Akahane (Department of Pharmacology, Toho University/School of Medicine)

P 17-3 Membrane Potential and Intracellular Calcium Oscillations in the Guinea-Pig

and Rat Pulmonary Vein Myocardium Iyuki Namekata, Yayoi Tsuneoka, Akiko Akiba, Hideki Nakamura, Hideaki Shimada, HikaruTanaka (Department of Pharmacology, Toho University Faculty of Pharmaceutical Sciences)

poster presentation 1 - convention.co.jp filethe 28th annual meeting of the international society...

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