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Page 1: PowerPoint Presentation · (GO). Plasma concentrations of each DAA were assessed over 24 hours. Maximum concentration (Cmax) and Area Under the Curve (AUC) were calculated for each
Page 2: PowerPoint Presentation · (GO). Plasma concentrations of each DAA were assessed over 24 hours. Maximum concentration (Cmax) and Area Under the Curve (AUC) were calculated for each
Page 3: PowerPoint Presentation · (GO). Plasma concentrations of each DAA were assessed over 24 hours. Maximum concentration (Cmax) and Area Under the Curve (AUC) were calculated for each
Page 4: PowerPoint Presentation · (GO). Plasma concentrations of each DAA were assessed over 24 hours. Maximum concentration (Cmax) and Area Under the Curve (AUC) were calculated for each
Page 5: PowerPoint Presentation · (GO). Plasma concentrations of each DAA were assessed over 24 hours. Maximum concentration (Cmax) and Area Under the Curve (AUC) were calculated for each

OVERVIEW

• HCV Global Situation Analysis

• Pharco Pharmaceuticals, (Access, R&D and

Challenges )

• What can we do to improve accessibility

worldwide ?

• Shortening HCV treatment to < 4 weeks

(Professor Raymond F Schinazi)

• Actions speak louder than words (Key Messages)

Page 6: PowerPoint Presentation · (GO). Plasma concentrations of each DAA were assessed over 24 hours. Maximum concentration (Cmax) and Area Under the Curve (AUC) were calculated for each
Page 7: PowerPoint Presentation · (GO). Plasma concentrations of each DAA were assessed over 24 hours. Maximum concentration (Cmax) and Area Under the Curve (AUC) were calculated for each
Page 8: PowerPoint Presentation · (GO). Plasma concentrations of each DAA were assessed over 24 hours. Maximum concentration (Cmax) and Area Under the Curve (AUC) were calculated for each
Page 9: PowerPoint Presentation · (GO). Plasma concentrations of each DAA were assessed over 24 hours. Maximum concentration (Cmax) and Area Under the Curve (AUC) were calculated for each
Page 10: PowerPoint Presentation · (GO). Plasma concentrations of each DAA were assessed over 24 hours. Maximum concentration (Cmax) and Area Under the Curve (AUC) were calculated for each
Page 11: PowerPoint Presentation · (GO). Plasma concentrations of each DAA were assessed over 24 hours. Maximum concentration (Cmax) and Area Under the Curve (AUC) were calculated for each
Page 12: PowerPoint Presentation · (GO). Plasma concentrations of each DAA were assessed over 24 hours. Maximum concentration (Cmax) and Area Under the Curve (AUC) were calculated for each
Page 13: PowerPoint Presentation · (GO). Plasma concentrations of each DAA were assessed over 24 hours. Maximum concentration (Cmax) and Area Under the Curve (AUC) were calculated for each
Page 14: PowerPoint Presentation · (GO). Plasma concentrations of each DAA were assessed over 24 hours. Maximum concentration (Cmax) and Area Under the Curve (AUC) were calculated for each
Page 15: PowerPoint Presentation · (GO). Plasma concentrations of each DAA were assessed over 24 hours. Maximum concentration (Cmax) and Area Under the Curve (AUC) were calculated for each
Page 16: PowerPoint Presentation · (GO). Plasma concentrations of each DAA were assessed over 24 hours. Maximum concentration (Cmax) and Area Under the Curve (AUC) were calculated for each
Page 17: PowerPoint Presentation · (GO). Plasma concentrations of each DAA were assessed over 24 hours. Maximum concentration (Cmax) and Area Under the Curve (AUC) were calculated for each

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Page 18: PowerPoint Presentation · (GO). Plasma concentrations of each DAA were assessed over 24 hours. Maximum concentration (Cmax) and Area Under the Curve (AUC) were calculated for each
Page 19: PowerPoint Presentation · (GO). Plasma concentrations of each DAA were assessed over 24 hours. Maximum concentration (Cmax) and Area Under the Curve (AUC) were calculated for each

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Page 20: PowerPoint Presentation · (GO). Plasma concentrations of each DAA were assessed over 24 hours. Maximum concentration (Cmax) and Area Under the Curve (AUC) were calculated for each
Page 21: PowerPoint Presentation · (GO). Plasma concentrations of each DAA were assessed over 24 hours. Maximum concentration (Cmax) and Area Under the Curve (AUC) were calculated for each
Page 22: PowerPoint Presentation · (GO). Plasma concentrations of each DAA were assessed over 24 hours. Maximum concentration (Cmax) and Area Under the Curve (AUC) were calculated for each
Page 23: PowerPoint Presentation · (GO). Plasma concentrations of each DAA were assessed over 24 hours. Maximum concentration (Cmax) and Area Under the Curve (AUC) were calculated for each

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Page 24: PowerPoint Presentation · (GO). Plasma concentrations of each DAA were assessed over 24 hours. Maximum concentration (Cmax) and Area Under the Curve (AUC) were calculated for each
Page 25: PowerPoint Presentation · (GO). Plasma concentrations of each DAA were assessed over 24 hours. Maximum concentration (Cmax) and Area Under the Curve (AUC) were calculated for each
Page 26: PowerPoint Presentation · (GO). Plasma concentrations of each DAA were assessed over 24 hours. Maximum concentration (Cmax) and Area Under the Curve (AUC) were calculated for each
Page 27: PowerPoint Presentation · (GO). Plasma concentrations of each DAA were assessed over 24 hours. Maximum concentration (Cmax) and Area Under the Curve (AUC) were calculated for each
Page 28: PowerPoint Presentation · (GO). Plasma concentrations of each DAA were assessed over 24 hours. Maximum concentration (Cmax) and Area Under the Curve (AUC) were calculated for each

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Page 29: PowerPoint Presentation · (GO). Plasma concentrations of each DAA were assessed over 24 hours. Maximum concentration (Cmax) and Area Under the Curve (AUC) were calculated for each
Page 30: PowerPoint Presentation · (GO). Plasma concentrations of each DAA were assessed over 24 hours. Maximum concentration (Cmax) and Area Under the Curve (AUC) were calculated for each
Page 31: PowerPoint Presentation · (GO). Plasma concentrations of each DAA were assessed over 24 hours. Maximum concentration (Cmax) and Area Under the Curve (AUC) were calculated for each
Page 32: PowerPoint Presentation · (GO). Plasma concentrations of each DAA were assessed over 24 hours. Maximum concentration (Cmax) and Area Under the Curve (AUC) were calculated for each
Page 33: PowerPoint Presentation · (GO). Plasma concentrations of each DAA were assessed over 24 hours. Maximum concentration (Cmax) and Area Under the Curve (AUC) were calculated for each
Page 34: PowerPoint Presentation · (GO). Plasma concentrations of each DAA were assessed over 24 hours. Maximum concentration (Cmax) and Area Under the Curve (AUC) were calculated for each
Page 35: PowerPoint Presentation · (GO). Plasma concentrations of each DAA were assessed over 24 hours. Maximum concentration (Cmax) and Area Under the Curve (AUC) were calculated for each
Page 36: PowerPoint Presentation · (GO). Plasma concentrations of each DAA were assessed over 24 hours. Maximum concentration (Cmax) and Area Under the Curve (AUC) were calculated for each
Page 37: PowerPoint Presentation · (GO). Plasma concentrations of each DAA were assessed over 24 hours. Maximum concentration (Cmax) and Area Under the Curve (AUC) were calculated for each
Page 38: PowerPoint Presentation · (GO). Plasma concentrations of each DAA were assessed over 24 hours. Maximum concentration (Cmax) and Area Under the Curve (AUC) were calculated for each
Page 39: PowerPoint Presentation · (GO). Plasma concentrations of each DAA were assessed over 24 hours. Maximum concentration (Cmax) and Area Under the Curve (AUC) were calculated for each
Page 40: PowerPoint Presentation · (GO). Plasma concentrations of each DAA were assessed over 24 hours. Maximum concentration (Cmax) and Area Under the Curve (AUC) were calculated for each
Page 41: PowerPoint Presentation · (GO). Plasma concentrations of each DAA were assessed over 24 hours. Maximum concentration (Cmax) and Area Under the Curve (AUC) were calculated for each

Shortening HCV treatment to < 4 weeks Raymond F Schinazi, PhD, DSc Francis Winship Walters Professor of Pediatrics and Chemistry

Emory University , Atlanta, GA, US

Place image here

Page 42: PowerPoint Presentation · (GO). Plasma concentrations of each DAA were assessed over 24 hours. Maximum concentration (Cmax) and Area Under the Curve (AUC) were calculated for each

Short Duration DAA Therapy for

Hepatitis C: How Short Can We Go?

Shyam Kottilil MD, Ph.D.

Institute of Human Virology, University of Maryland, Baltimore, MD

HEPDART

Kona, HI

December 4, 2017

Page 43: PowerPoint Presentation · (GO). Plasma concentrations of each DAA were assessed over 24 hours. Maximum concentration (Cmax) and Area Under the Curve (AUC) were calculated for each

Short Duration HCV Therapy

Emmanuel B…..Kottilil S. Lau G. (2017) Lancet G&H

Page 44: PowerPoint Presentation · (GO). Plasma concentrations of each DAA were assessed over 24 hours. Maximum concentration (Cmax) and Area Under the Curve (AUC) were calculated for each
Page 45: PowerPoint Presentation · (GO). Plasma concentrations of each DAA were assessed over 24 hours. Maximum concentration (Cmax) and Area Under the Curve (AUC) were calculated for each
Page 46: PowerPoint Presentation · (GO). Plasma concentrations of each DAA were assessed over 24 hours. Maximum concentration (Cmax) and Area Under the Curve (AUC) were calculated for each
Page 47: PowerPoint Presentation · (GO). Plasma concentrations of each DAA were assessed over 24 hours. Maximum concentration (Cmax) and Area Under the Curve (AUC) were calculated for each
Page 48: PowerPoint Presentation · (GO). Plasma concentrations of each DAA were assessed over 24 hours. Maximum concentration (Cmax) and Area Under the Curve (AUC) were calculated for each

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Page 49: PowerPoint Presentation · (GO). Plasma concentrations of each DAA were assessed over 24 hours. Maximum concentration (Cmax) and Area Under the Curve (AUC) were calculated for each
Page 50: PowerPoint Presentation · (GO). Plasma concentrations of each DAA were assessed over 24 hours. Maximum concentration (Cmax) and Area Under the Curve (AUC) were calculated for each

Key Messages

1) Egypt succeeded in transferring its position from the highest prevalence of infection with Hepatitis C worldwide, to the first country to treat all waiting list (No Patient left Behind).

2) Under the umbrella of WHO, partnership between DNDi, MPP, and Governments of low and medium income countries to find solutions for cancer and NCDs. (Together We Can).

3) Together we can eliminate Hepatitis C from low and

medium income countries, saving hundreds of thousands

of lives annually, (Stop The Wait).

Page 51: PowerPoint Presentation · (GO). Plasma concentrations of each DAA were assessed over 24 hours. Maximum concentration (Cmax) and Area Under the Curve (AUC) were calculated for each
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