prabhava- the ultimate action of a dravya
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TRANSCRIPT
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Is this knowledge enough???
Do we have to explore & revive the intricacies of the basic knowledge we possess…..
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Do question, even the basics!You will be a fool for once!If you don't, you will be, for a lifetime..” ― Himmilicious
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Reviving the concept ofPrabhava
Department of Dravyagunavijnana
VPSV Ayurveda College,Kottakkal
Dr. Praseetha P G Dr.N.Manojkumar
I MD Scholar Reader
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1. Origin of the concept
2. Defining Prabhava
3. Concept in detail
4. Authenticity
5. Importance of Prabhava
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Prabhava
प्र + भू� + घञ्�
(वै�चास्पत्यमा�)“ प्रकृ� ष्टो भू�वै प्रभू�वै:”
प्रभूवैति" सू�मात्य#तिवैशि%ष्टो भूवैति" द्रव्य अना'ना इति" प्रभू�वै: I
(चाक्रप�णिणं)
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Defining Prabhava
रसूवै+य#तिवैप�कृ�ना� सू�मा�न्य यत्र लक्ष्य"' I तिवै%'ष: कृमा#णं� चा�वै प्रभू�वैस्"स्य सू स्मा�":II
(चा.सू�-२६)
रसूवै+य#तिवैप�कृ�ना� परस्परसू�म्य' अतिप यद्� तिवैशि%ष्टो कृमा# दृश्य"' ""� प्रभू�वैजं तिवैद्धि9 I
(इन्दु)
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Concept of Prabhava
प्रभू�वै अशिचान्त्य: कृ=दृकृ� कृद्� कृ> "स्य इति" ज्ञा�"> ना %क्य"'
सूद्तिप "त्कृ�रणं माहा�भू�"तिवै%'षपरिरणं�मा�ख्यअस्मातिDधै�: "त्र�यिधैगन्"> ना %क्य": इत्यर्थ#:
(इन्दु)
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Various terminologies
रसूग>णंभू�"सूमा>द्�य�श्च एष� अनावैधै�रणं+य "र्थ�रसूभू�"सूमा>द्�य�ना� अन्य'ष� अन्यर्थ�वै+य#त्वै�"�
(ना�ग�जं>#ना)
अमा+मा�स्य�न्यशिचान्त्य�तिना प्रशिसू9�तिना स्वैभू�वै":
आगमा'ना पय ज्य�तिना भू'षजं�तिना तिवैचाक्षणं�:(सू>.सू�-४०)
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प्रत्यक्षलक्षणंफल�: प्रशिसू9�श्च स्वैभू�वै":
नाOषधै+हाP">णिभूर्विवैR9�ना� पर+क्ष'" कृद्�चानाI
सूहास्रे'णं�तिप हा'"�ना� ना�म्बष्टो�दिद्र्विवैRर'च्य"' "स्मा�णिWष्ठे'W> माति"मा�ना� आगमा' ना "> हा'">ष>II
(सू>.सू�-४०)
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Different interpretation
Cakrapani:
Veerya-
Chintya sakthi
Achintya sakthi
"त्द्र�व्यमा�त्माना� तिकृञ्चिञ्चा"� Prabhava
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Passing time & changing theories
Hallmark of many systems of medicine
Certain levels of uncertainty
What to believe? What to forget ?
Approximate or Accurate?
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Ayurveda- The Eternal Science
Time tested science of life
Time-tested theories
Accept defeat rather than fake win
Reasoning beyond one’s logic
Prabhava
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अप्रधै�ना�: प�र्थकृ� "स्मा�द्� रसू� द्या�: सूणिश्र"�स्"> "' I प्रभू�वै�श्च य" द्रव्य' द्रव्य श्र'ष्ठेमा" मा"मा�II
(अ.सू.सू�-१७)
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Importance of Prabhava
Acintya
Daivapratighata
Visapratighata
Darsanat
Sravanat
Tulyarsagunesu Visesata
Adhbuta Karma
Agama
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Prabhavaja Karmas
• Aushadikarma - Pharmacological• Agadiyakarma – Toxic & Antitoxic• Rakshoghnakarma- Antimicrobial• Bhautikakarma – Physical • Manasakarma -
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Anthraquinines & Carbohydrates
• Pharmacognostic Studies on the Roots of Baliospermum
Raziana keshav Et Yog. G.V.R. Joseph , CCRAS,Kerala
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Tikta RasaT2Rs- T2R4, T2R107 and T2R38 expressed in multiple regions of the rat brain-brain stem,
cerebellum, cortex and nucleus accumbens. Functional bitter taste receptors are expressed in brain cells.• Singh N, Vrontakis M, Parkinson F, Chelikani P
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Sweet Taste
• The heterodimeric sweet taste receptor has multiple
potential ligand binding sites.
Cui M et.al, Mount Sinai School of Medicine,Newyork
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Rakshoghna karma
Anti-microbial activity
• Antimicrobial Activity of Clitoria ternatea (L.) Extracts
L. Kamilla et.al
• In vitro assessment of potenial of Commiphora whighti(Arn) gum extract
Kalpesh.B et.alo
• n
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Manidharana & MantrasPsychologicalColourVibrationsAsterism & Chatoyancy• Rendering gems with aterism or
chatoyancy S Yokoi, K Kurashige, J Toriwaki - The Visual Computer, 1986 – Springer
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Garbhasaya Rasayana
Active principles-
one stimulating and the other relaxing
Stimulate the uterus, making the contraction more frequent and prolonged.
Crystalline glycoside stimulate uterine contraction
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• Oxytocic activity of a pure phenolic glycoside (P2) from Saraca indica Linn (Ashoka): a short communication.
Satyavati GV et al• Ashoka (Saraca indica) increase estrogen
levels and normalize the endometrium during menstruation (The Antiseptic, Vol.95, October 1998, p.329).
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• Mechanistic clues in cardioprotective effect of Terminalia arjuna bark extract in isoprotrenol -induced chronic heart failure in rats.
Parveen A, Babbar R, Agarwal S, Kotwani A
Department of Physiology, Maulana Azad Medical College, University of Delhi, India
• Antianginal and cardioprotective effects of Terminalia arjuna, an indigenous drug, in coronary artery disease.
Dwivedi S, Agarwal MP.
Department of Medicine, UCMS, Delhi
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Receptor- Effector Theory
• Receptor:
Macromolecule/ Binding site on or inside effector cell
To recognise the signal molecule/ drug
Initiate response
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Types
Type 1 : Channel-linkedType 2 : G-protien-coupledType 3 : Kinase-linkedType 4 : Gene transcription
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Induced Fit
• A situation where the receptor changes shape as it binds to a ligand so that its binding site more closely conforms to the shape of the ligand.
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Active Chemical Constituents
That performs the intended chemistry or biochemisrty
Inducing specific response
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द्रव्य�णिणं तिहा द्रव्यप्रभू�वै�द्� ग>णंप्रभू�वै�द्� द्रव्यग>णंप्रभू�वै�च्च "स्मिस्माना� "स्मिस्माना� कृ�ल' "त्त्द्यिधैकृरणंमा�सू�द्या� "� "� चा
य>शि^मार्थ_ चा " "माणिभूप्र'त्य य"� कृ> वै#न्तिन्" ""� कृमा# I (चा.सू�-२६)
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Conclusion
Indication for further Research
Substitution
Use of single drugs
Identification of specific chemical constituents
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Reference
• Rendering gems with aterism or chatoyancy
S Yokoi, K Kurashige, J Toriwaki - The Visual Computer, 1986 – Springer