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PRECIOUS MOVEMENTS, PRECIOUS MOMENTS Symptomatic slow-acting treatment of hip and knee osteoarthritis Piascledine_Patient_Leaflet-148x210-090915_EN.indd 1 11/09/2015 15:27

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PRECIOUS MOVEMENTS,PRECIOUS MOMENTS

Symptomatic slow-acting treatment of hip and knee osteoarthritis

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Bone (including osteoblasts)

Synovial Membrane

Articular cartilage

Fibrous joint capsule

Joint cavity filled with synovial fluid

Ligaments

What is osteoarthritis?

Arthritis is a general term that means “joint inflammation”. Osteoarthritis (OA) is a type of arthritis. It occurs when the cartilage covering the end of the bones thins and eventually wears away, leading to pain as the bones rub against each other. Inflammation usually accompanies cartilage breakdown and contributes to pain and disability.

What causes osteoarthritis?

In most cases of OA, the specific cause of disease is not known. How- ever, certain factors may increase the risk of developing OA. Some of these risk factors include: heredity, advanced age, obesity, joint injury or joint overuse.

What joints does osteoarthritis affect?

OA can occur in any joint, but most often affects the hands and weight- bearing joints such as the hips, knees, and in the spine. OA of the hip and knee are the most debilitating forms of the disease.

Is osteoarthritis common?

Yes. In fact, OA is the most common joint disease in the world. The WHO (World Health Organization) estimates that about 10% of the world’s population over 60 years of age has OA.1

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Who does osteoarthritis affect?

OA affects people of all ethnic groups in all geographic locations. Elderly people are especially affected by OA. After the age of 40, the incidence of OA increases rapidly with each passing decade in all joints. This is likely due to an accumulated exposure to various risk factors, such as weight gain and joint stress. In addition, after the age of 50, OA affects more women than men, and women are more likely to have severe OA as well.

What are the symptoms of osteoarthritis?

Common symptoms of OA include:

Joint pain during or after use, or after a period of inactivity

Joint tenderness, stiffness, or sometimes swelling

Bony enlargements in the middle and end joints of the fingers

These symptoms of OA tend to develop gradually and may get worse over time.

How does osteoarthritis impact the lives of those affected?

OA may affect life in 2 ways:

First, the pain associated with OA may impact quality of life, as it may reduce mobility, thereby impairing the ability to work and limiting daily activities.

Second, OA may affect mental health. Living with pain and disability can cause prolonged stress, negatively affecting emotional health and well-being.

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How is osteoarthritis diagnosed?

In addition to assessing joint pain and mobility impairment, doctors may also use X-rays to help diagnose OA. X-rays can reveal if and how much cartilage has been lost from the affected joint(s). Sometimes blood tests are also done to rule out other forms of arthritis.

How is osteoarthritis treated?

Although there is no known cure for OA, the available treatments can help to reduce pain and improve joint function. Currently, there are 3 types of treatment strategies:

Education and lifestyle changes: Recommende d first line, they include weight reduction, pain management strategies, exercise, physical therapy and/or walking aids.

Medication: To decrease joint inflammation and pain; may include creams, pills, or injections directly into the affected joint(s). There are 2 main types of oral medication:

Fast-acting anti-inflammatory drugs, which include paracetamol and Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) such as ibuprofen

SYmptomatic Slow-Acting Drugs for OA (SYSADOA), which include avocado/soybean oil unsaponifiables (ASU), chondroitin, glucosamine and diacerein

Surgery: Reserved for the most severe cases (e.g. joint replacement)

How do fast-acting anti-inflammatory drugs work?

As their name implies, these drugs are used for immediate relief from pain and inflammation in the joints. Although they may help to control pain and improve function in the short-term, they are associated with gastrointestinal (GI) distress, such as upset stomach, cramping, diarrhea, ulcers and even bleeding. Newer types of NSAIDs, called COX-2 selective inhibitors, are associated with fewer GI side effects but increase the risk for cardiovascular disease.

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How do Symptomatic Slow-Acting Drugs for Osteoarthritis (SYSADOA) work?

SYSADOA relieve OA pain and help improve joint function over the long- term. They also help to lessen the use of anti-inflammatory medications, thereby lowering the risk of gastrointestinal side effects.2-4

What are avocado and soybean oil unsaponifiables (ASU) and how do they work?

ASU are natural vegetable extracts made from avocado and soybean oils. Experts think ASU slows the production of some inflammatory chemicals which cause the breakdown of cartilage in OA-affected joints. Taking ASU may help to slow or even prevent the breakdown of cartilage which occurs in OA.

Osteoarthritis (OA) is a joint inflammation in which the cartilage covering the bones thins and eventually wears off.

The cause of OA is not known, but many risk factors may increase the risk of developing it: heredity, advanced age, obesity and joint injury or overuse.

OA is the most common joint disease. It affects 10% of people over 60 years of age around the world.

OA impacts both quality of life and emotional health and well-being.

Treatment of arthritis consists of:• Lifestyle changes, such as weight loss and physical therapy• Medication, such as fast acting anti-inflammatory drugs and SYSADOA

(Symptomatic Slow-Acting Drugs for OA)• Surgery, such as joint replacement in the most severe cases

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My doctor has prescribedPIASCLEDINE®300 for my osteoarthritis

What types of OA can PIASCLEDINE®300 be used to treat?

PIASCLEDINE®300 is indicated to treat the symptoms of hip and knee OA.

Has PIASCLEDINE®300 been shown to work?Yes. Several clinical trials have demonstrated the efficacy and tolerability of PIASCLEDINE®300 in the treatment of hip and knee OA. Specifically, PIASCLEDINE®300 has been shown to reduce pain, improve joint function, and reduce reliance on NSAIDs for pain relief.3,5,6

What is PIASCLEDINE®300?PIASCLEDINE®300 presents as a 300 mg capsule composed of avocado oil unsaponifiables (100 mg/capsule) and soya oil unsaponifiables (200 mg/capsule).

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When can I expect to notice the benefits of taking PIASCLEDINE®300?

In clinical studies conducted with patients suffering from hip and knee OA, patients given PIASCLEDINE®300 noticed improvements in symptoms after only 1 month6 and were less likely to resume NSAID therapy after only 6 weeks of treatment.5 PIASCLEDINE®300 was also shown to reduce pain and improve function after only 2 months of treatment.3

How and when will I take PIASCLEDINE®300 capsules?

One capsule of PIASCLEDINE®300 (300 mg) should be taken once a day during a meal with a large glass of water.

Is PIASCLEDINE®300 known to interact with other drugs?

No. PIASCLEDINE®300 does not have any reported drug-drug interactions.

Is PIASCLEDINE®300 known to have any side effects?

PIASCLEDINE®300 is usually very well-tolerated, however, some patients may experience side effects.7 Regurgitation of a “fatty” odour may occur, but can be prevented by taking capsules during a meal. Also, some patients may experience mild gastrointestinal side effects which tend to resolve spontaneously. Rarely, patients may experience hyper-sensitivity reactions or elevations of liver enzymes.

Are there any precautions to taking PIASCLEDINE®300?

PIASCLEDINE®300 is not recommended during pregnancy or lactation due to a lack of clinical studies on the effect of PIASCLEDINE®300 during fetal development.

1. Symmons D, et al. Geneva: World Health Organization, 2004. 2. Zhang W, Moskowitz RW, Nuki G et al. OARSI recommendations for the management

of hip and knee osteoarthritis. Osteoarthritis Cartilage 2008;16:137-62.3. Maheu E, et al. Arthritis Rheum 1998;41:81-91.4. Dougados M. Joint Bone Spine 2006; 73: 606-9.5. Blotman F, et al. Rev Rhum (Engl Ed) 1997;64:825-34.6. Appelboom T, et al. Scand

J Rheumatol 2001;30:242-7. 7. PIASCLEDINE®300

Information for the user.

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For more information on osteoarthritis, please visit our website

Laboratoires Expanscience

10, avenue de l’Arche, 92419 Courbevoie Cedex - FranceTél.: +33 (0)1 43 34 60 00 - Fax : +33 (0)1 43 34 61 00

www.expanscience.com

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