prescription drug list changes - cigna...nutritional/dietary pregenna, trinaz any generic prenatal...

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Generic medications start with a lowercase letter and brand name medications start with a capital letter. 951714 UPDATED_05/21/2021 Changes are being made to Cigna’s Prescription Drug List (formulary) that may affect some of your patients. These changes are listed by formulary name and by effective date. Below is the list of medications that are changing coverage levels. Please note that the coverage status of medications under our Prescription Drug Lists are always subject to the cost-share requirements, exclusions and coverage limitations of particular benefit plans. Drug lists used by patients who have coverage through their employer STANDARD FORMULARY PRESCRIPTION DRUG LIST CHANGES For Providers 2021 Start date of change* , ** Drug class Medications moving to preferred brand June 22, 2021 PAIN RELIEF AND INFLAMMATORY DISEASE Reditrex May 15, 2021 EYE CONDITIONS Eysuvis GASTROINTESTINAL/HEARTBURN Sutab January 1, 2021 AIDS/HIV Juluca ASTHMA/COPD/RESPIRATORY Bevespi DIABETES Baqsimi GASTROINTESTINAL/HEARTBURN Pancreaze INFECTIONS Epclusa, Harvoni PAIN RELIEF AND INFLAMMATORY DISEASE Taltz Start date of change* , ** Drug class Medications becoming non-preferred brand Generic and/or preferred brand alternatives June 29, 2021 BLOOD PRESSURE/HEART MEDICATIONS Orladeyo 1 Lupron Depot June 22, 2021 CANCER Orgovyx 1 No preferred formulary drug alternatives. June 15, 2021 GASTROINTESTINAL/HEARTBURN Lubiprostone 8 mcg, 24 mcg capsule Amitiza June 1, 2021 SKIN CONDITIONS Winlevi 1% cream Generic products (e.g. adapalene; tretinoin; clindamycin-benzoyl peroxide) Wynzora 0.005%-0.064% cream betamethasone DP, fluocinolone, fluticasone, mometasone, trimacinolone, calcipotriene, calcipotriene-betamethasone DP

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Page 1: PRESCRIPTION DRUG LIST CHANGES - Cigna...NUTRITIONAL/DIETARY PreGenna, Trinaz Any generic prenatal vitamin PAIN RELIEF AND INFLAMMATORY DISEASE Amerge generic triptans (e.g. naratriptan;

Generic medications start with a lowercase letter and brand name medications start with a capital letter.

951714 UPDATED_05/21/2021

Changes are being made to Cigna’s Prescription Drug List (formulary) that may affect some of your patients. These changes are listed by formulary name and by effective date.

Below is the list of medications that are changing coverage levels. Please note that the coverage status of medications under our Prescription Drug Lists are always subject to the cost-share requirements, exclusions and coverage limitations of particular benefit plans.

Drug lists used by patients who have coverage through their employer

STANDARD FORMULARY

PRESCRIPTION DRUG LIST CHANGES

For Providers 2021

Start date of change*,**

Drug class Medications moving to preferred brand

June 22, 2021 PAIN RELIEF AND INFLAMMATORY DISEASE Reditrex

May 15, 2021 EYE CONDITIONS Eysuvis

GASTROINTESTINAL/HEARTBURN Sutab

January 1, 2021 AIDS/HIV Juluca

ASTHMA/COPD/RESPIRATORY Bevespi

DIABETES Baqsimi

GASTROINTESTINAL/HEARTBURN Pancreaze

INFECTIONS Epclusa, Harvoni

PAIN RELIEF AND INFLAMMATORY DISEASE Taltz

Start date of change*,**

Drug classMedications becoming non-preferred brand

Generic and/or preferred brand alternatives

June 29, 2021 BLOOD PRESSURE/HEART MEDICATIONS Orladeyo1 Lupron Depot

June 22, 2021 CANCER Orgovyx1 No preferred formulary drug alternatives.

June 15, 2021 GASTROINTESTINAL/HEARTBURN Lubiprostone 8 mcg, 24 mcg capsule Amitiza

June 1, 2021 SKIN CONDITIONS Winlevi 1% cream Generic products (e.g. adapalene; tretinoin; clindamycin-benzoyl peroxide)

Wynzora 0.005%-0.064% cream betamethasone DP, fluocinolone, fluticasone, mometasone, trimacinolone, calcipotriene, calcipotriene-betamethasone DP

Page 2: PRESCRIPTION DRUG LIST CHANGES - Cigna...NUTRITIONAL/DIETARY PreGenna, Trinaz Any generic prenatal vitamin PAIN RELIEF AND INFLAMMATORY DISEASE Amerge generic triptans (e.g. naratriptan;

STANDARD FORMULARY (cont)

Generic medications start with a lowercase letter and brand name medications start with a capital letter.

Start date of change*,**

Drug classMedications becoming non-preferred brand

Generic and/or preferred brand alternatives

June 1, 2021 URINARY TRACT CONDITIONS Vesicare LS 5 mg/5 mL suspension oxybutynin chloride, oxybutynin chloride ER, darifenacin ER, solifenacin, tolterodine, tolterodine ER, tropsium

May 15, 2021 EYE CONDITIONS Lacrisert Restasis, Restasis Multi-dose, Xiidra

May 2, 2021 PAIN RELIEF AND INFLAMMATORY DISEASE Qdolo tramadol

May 1, 2021 SKIN PREPS Impeklo topical betamethasone dipropionate (augmented) 0.05%, clobetasol propionate 0.05%, halobetasol propionate 0.05%, fluocinolide 0.1%

April 18, 2021 HORMONAL AGENTS Alkindi Sprinkle hydrocortisone 5mg tablet

March 28, 2021 BLOOD PRESSURE/HEART MEDICATIONS Conjupri amlodipine, felodipine, nifedipine, nicardipine

January 1, 2021 AIDS/HIV Intelence1 Talk to your doctor about other alternatives

BLOOD MODIFIERS/BLEEDING DISORDERS Amicar 0.25 g/ml oral solution1 aminocaproic acid 0.25g/ml oral solution

BLOOD PRESSURE/HEART MEDICATIONS Multaq, Norpace CR 150mg Talk to your doctor about other alternatives

CANCER Tabloid Talk to your doctor about other alternatives

ERECTILE DYSFUNCTION Caverject Impulse Syringe MUSE

EYE CONDITIONS Lotemax 0.5% drops loteprednol 0.5% drops

HORMONAL AGENTS Armour Thyroid, Synthroid, Unithroid levothyroxine

INFECTIONS Kitabis Pak1 tobramycin pak 300mg/5ml

SEIZURE DISORDERS Lyrica 20mg/ml oral solution pregabalin 20mg/ml oral solution

SUBSTANCE ABUSE Bunavail buprenorphine/naloxone film or sublingual tablet, Zubsolv

WEIGHT MANAGEMENT Megace ES 625mg/5ml oral suspension megestrol 625ml/5ml oral suspensionStart date of change*,**

Drug class Medications that will need approval (prior authorization)^

June 29, 2021 BLOOD PRESSURE/HEART MEDICATIONS Orladeyo1

June 22, 2021 PAIN RELIEF AND INFLAMMATORY DISEASE Reditrex

June 1, 2021 ASTHMA/COPD/RESPIRATORY Zokinvy

March 14, 2021 CANCER Gavreto

January 1, 2021 BLOOD THINNERS/ANTI-CLOTTING Eliquis4, Pradaxa4, Savaysa4, Xarelto4

PAIN RELIEF AND INFLAMMATORY DISEASE diclofenac 1.3% patch, Flector 1.3% patch5, Voltaren 1% gel5

Start date of change*,**

Drug class Medications that will have a quantity limit

June 29, 2021 BLOOD PRESSURE/HEART MEDICATIONS Orladeyo1

June 1, 2021 ASTHMA/COPD/RESPIRATORY Zokinvy

May 15, 2021 EYE CONDITIONS Eysuvis

May 2, 2021 PAIN RELIEF AND INFLAMMATORY DISEASE Qdolo

Page 3: PRESCRIPTION DRUG LIST CHANGES - Cigna...NUTRITIONAL/DIETARY PreGenna, Trinaz Any generic prenatal vitamin PAIN RELIEF AND INFLAMMATORY DISEASE Amerge generic triptans (e.g. naratriptan;

STANDARD FORMULARY (cont)

Generic medications start with a lowercase letter and brand name medications start with a capital letter.

Start date of change*,**

Drug class Medications that will have a quantity limit

March 14, 2021 CANCER GavretoStart date of change*,**

Drug classMedications that will no longer be covered^^

Generic and/or preferred brand alternatives

June 29, 2021 SKIN CONDITIONS Klisyri topical fluorouracil, imiquimod 5% cream

June 22, 2021 GASTROINTESTINAL/HEARTBURN Reltone ursodiol

HORMONAL AGENTS Thyquidity levothyroxine, levoxyl, Levo-T, Unithroid, Euthyrox

June 15, 2021 GASTROINTESTINAL/HEARTBURN Lubiprostone 8 mcg, 24 mcg capsule Amitiza

June 1, 2021 SKIN CONDITIONS Winlevi 1% cream Generic products (e.g. adapalene; tretinoin; clindamycin-benzoyl peroxide)

June 1, 2021 SKIN CONDITIONS (cont) Wynzora 0.005%-0.064% cream betamethasone DP, fluocinolone, fluticasone, mometasone, trimacinolone, calcipotriene, calcipotriene-betamethasone DP

URINARY TRACT CONDITIONS Vesicare LS 5 mg/5 mL suspension oxybutynin chloride, oxybutynin chloride ER, darifenacin ER, solifenacin, tolterodine, tolterodine ER, tropsium

May 2, 2021 PAIN RELIEF AND INFLAMMATORY DISEASE Qdolo tramadol

May 1, 2021 SKIN PREPS Impeklo topical betamethasone dipropionate (augmented) 0.05%, clobetasol propionate 0.05%, halobetasol propionate 0.05%, fluocinolide 0.1%

April 18, 2021 HORMONAL AGENTS Alkindi Sprinkle hydrocortisone 5mg tablet

March 28, 2021 BLOOD PRESSURE/HEART MEDICATIONS Conjupri amlodipine, felodipine, nifedipine, nicardipine

January 1, 2021 ASTHMA/COPD/RESPIRATORY ProAir HFA7, ProAir RespiClick7, Ventolin HFA7

albuterol HFA

DIABETES Kombiglyze XR8, Onglyza8 metformin, Janumet, Janumet XR, Januvia

EYE CONDITIONS Lumigan7, Travatan Z, Xalatan, Xelpros, Zioptan9

bimatoprost, latanoprost, travoprost

GASTROINTESTINAL/HEARTBURN Creon7, Pertzye, Zenpep7 Pancreaze

Motegrity, Trulance7, Zelnorm Amitiza, Linzess

Sensipar cinacalcet

HORMONAL AGENTS TaperDex dexamethasone 1.5mg tablet

INFECTIONS Baraclude entecavir tablet

Noxafil tablet posaconazole DR 100mg tablet

MULTIPLE SCLEROSIS Ampyra ER7 dalfampridine ER

NUTRITIONAL/DIETARY PreGenna, Trinaz Any generic prenatal vitamin

PAIN RELIEF AND INFLAMMATORY DISEASE Amerge generic triptans (e.g. naratriptan; sumatriptan)

Page 4: PRESCRIPTION DRUG LIST CHANGES - Cigna...NUTRITIONAL/DIETARY PreGenna, Trinaz Any generic prenatal vitamin PAIN RELIEF AND INFLAMMATORY DISEASE Amerge generic triptans (e.g. naratriptan;

STANDARD FORMULARY (cont)

Generic medications start with a lowercase letter and brand name medications start with a capital letter.

Start date of change*,**

Drug classMedications that will no longer be covered^^

Generic and/or preferred brand alternatives

January 1, 2021 PAIN RELIEF AND INFLAMMATORY DISEASE butalbital-acetaminophen 50-300mg tablet butalbutal-acetaminophen 50-325mg tablet

Cosentyx10 Enbrel, Humira, Otezla, Skyrizi, Stelara, Taltz

Frova, Maxalt, Maxalt MLT, Relpax generic triptans (e.g. naratriptan; sumatriptan)

SEIZURE DISORDERS Felbatol11 felbamate

Keppra/Keppra XR11 levetiracetam/levetiracetam ER

Lamictal XR Start Kit11 lamotrigine ER

Lamictal/ODT/XR11 lamotrigine, lamotrigine ER, lamotrigine ODT

Qudexy XR11, Trokendi XR11 topiramate ER

Sabril11 vigabatrin, vigadrone

Topamax11 topiramate

Trileptal11 oxcarbazepine

Zonegran11 zonisamide

SKIN CONDITIONS Apexicon E5, diflorasone, Impoyz5, Olux5, Olux-E5, psorcon

betamethasone, clobetasol, halobetasol

Condylox imiquimod 5% cream packet, podofilox 0.5% topical solution

Cordran5 betamethasone, clobetasol, fluocinolone, fluticasone, halobetasol

Finacea Foam7, Finacea Gel, MetroCream, MetroGel, MetroLotion, Soolantra12

azelaic acid, topical metronidazole

flurandrenolide, hydrocortisone butyrate lipid cream, lotion5, Pandel5

betamethasone, fluocinolone, fluticasone

Sorilux calcitriol, tazarotene, topical calcipotriene

Tridesilon5 alclometasone, desonide, triamcinolone

Xolegel ciclopirox 0.77% gel, ciclopirox 1% shampoo, ketoconazole 2% cream, ketoconazole 2% foam, selenium 2.5% lotion, sodium sulfacetamide 10% shampoo

SLEEP DISORDERS/SEDATIVES Belsomra8 DayvigoURINARY TRACT CONDITIONS Procysbi4 Cystagon

Start date of change*,**

Drug classMedications that will be excluded from coverage

Additional information

January 1, 2021 SKIN CONDITIONS Rosadan Kits azelaic acid, topical metronidazole

Page 5: PRESCRIPTION DRUG LIST CHANGES - Cigna...NUTRITIONAL/DIETARY PreGenna, Trinaz Any generic prenatal vitamin PAIN RELIEF AND INFLAMMATORY DISEASE Amerge generic triptans (e.g. naratriptan;

Generic medications start with a lowercase letter and brand name medications start with a capital letter.

VALUE FORMULARY

Start date of change*,**

Drug class Medications moving to preferred brand

June 22, 2021 PAIN RELIEF AND INFLAMMATORY DISEASE Reditrex

May 15, 2021 EYE CONDITIONS Eysuvis

GASTROINTESTINAL/HEARTBURN Sutab

January 1, 2021 AIDS/HIV Juluca

DIABETES Baqsimi

GASTROINTESTINAL/HEARTBURN Pancreaze

INFECTIONS Epclusa, Harvoni

PAIN RELIEF AND INFLAMMATORY DISEASE Ajovy13, Emgality13, Taltz

SEIZURE DISORDERS Vimpat

URINARY TRACT CONDITIONS Cystagon

Start date of change*,**

Drug classMedications becoming non-preferred brand

Generic and/or preferred brand alternatives

June 29, 2021 BLOOD PRESSURE/HEART MEDICATIONS Orladeyo1 No preferred formulary drug alternatives

June 22, 2021 CANCER Orgovyx1 Lupron Depot

June 15, 2021 GASTROINTESTINAL/HEARTBURN Lubiprostone 8 mcg, 24 mcg capsule Amitiza

June 1, 2021 SKIN CONDITIONS Winlevi 1% cream Generic products (e.g. adapalene; tretinoin; clindamycin-benzoyl peroxide)

Wynzora 0.005%-0.064% cream betamethasone DP, fluocinolone, fluticasone, mometasone, trimacinolone, calcipotriene, calcipotriene-betamethasone DP

URINARY TRACT CONDITIONS Vesicare LS 5 mg/5 mL suspension oxybutynin chloride, oxybutynin chloride ER, darifenacin ER, solifenacin, tolterodine, tolterodine ER, tropsium

May 2, 2021 PAIN RELIEF AND INFLAMMATORY DISEASE Qdolo tramadol

May 1, 2021 SKIN PREPS Impeklo topical betamethasone dipropionate (augmented) 0.05%, clobetasol propionate 0.05%, halobetasol propionate 0.05%, fluocinolide 0.1%

April 18, 2021 HORMONAL AGENTS Alkindi Sprinkle hydrocortisone 5mg tablet

March 28, 2021 BLOOD PRESSURE/HEART MEDICATIONS Conjupri amlodipine, felodipine, nifedipine, nicardipine

January 1, 2021 AIDS/HIV Intelence1 Talk to your doctor about other alternatives

ERECTILE DYSFUNCTION Caverject Impulse Syringe MUSE

HORMONAL AGENTS Unithroid 75mcg tablet levothyroxine

INFECTIONS Kitabis Pak1 tobramycin pak 300mg/5ml

SEIZURE DISORDERS Lyrica 20mg/ml oral solution pregabalin 20mg/ml oral solution

SUBSTANCE ABUSE Bunavail buprenorphine/naloxone film or sublingual tablet, Zubsolv

WEIGHT MANAGEMENT Megace ES 625mg/5ml oral suspension megestrol 625ml/5ml oral suspension

Page 6: PRESCRIPTION DRUG LIST CHANGES - Cigna...NUTRITIONAL/DIETARY PreGenna, Trinaz Any generic prenatal vitamin PAIN RELIEF AND INFLAMMATORY DISEASE Amerge generic triptans (e.g. naratriptan;

Generic medications start with a lowercase letter and brand name medications start with a capital letter.

VALUE FORMULARY (cont)

Start date of change*,**

Drug class Medications that will need approval (prior authorization)^

June 29, 2021 BLOOD PRESSURE/HEART MEDICATIONS Orladeyo1

June 22, 2021 PAIN RELIEF AND INFLAMMATORY DISEASE Reditrex

June 1, 2021 ASTHMA/COPD/RESPIRATORY Zokinvy

March 14, 2021 CANCER Gavreto

January 1, 2021 BLOOD THINNERS/ANTI-CLOTTING Eliquis4, Pradaxa4, Savaysa4, Xarelto4

HORMONAL AGENTS Tirosint, Tirosint-Sol

Start date of change*,**

Drug class Medications that will have a quantity limit

June 29, 2021 BLOOD PRESSURE/HEART MEDICATIONS Orladeyo1

June 1, 2021 ASTHMA/COPD/RESPIRATORY Zokinvy

May 15, 2021 EYE CONDITIONS Eysuvis

May 2, 2021 PAIN RELIEF AND INFLAMMATORY DISEASE Qdolo

March 14, 2021 CANCER Gavreto

Start date of change*,**

Drug classMedications that will no longer be covered^^

Generic and/or preferred brand alternatives

June 29, 2021 SKIN CONDITIONS Klisyri topical fluorouracil, imiquimod 5% cream

June 22, 2021 GASTROINTESTINAL/HEARTBURN Reltone ursodiol

HORMONAL AGENTS Thyquidity levothyroxine, levoxyl, Levo-T, Unithroid, Euthyrox

June 15, 2021 GASTROINTESTINAL/HEARTBURN Lubiprostone 8 mcg, 24 mcg capsule Amitiza

June 1, 2021 SKIN CONDITIONS Winlevi 1% cream Generic products (e.g. adapalene; tretinoin; clindamycin-benzoyl peroxide)

Wynzora 0.005%-0.064% cream betamethasone DP, fluocinolone, fluticasone, mometasone, trimacinolone, calcipotriene, calcipotriene-betamethasone DP

URINARY TRACT CONDITIONS Vesicare LS 5 mg/5 mL suspension oxybutynin chloride, oxybutynin chloride ER, darifenacin ER, solifenacin, tolterodine, tolterodine ER, tropsium

May 2, 2021 PAIN RELIEF AND INFLAMMATORY DISEASE Qdolo tramadol

May 1, 2021 SKIN PREPS Impeklo topical betamethasone dipropionate (augmented) 0.05%, clobetasol propionate 0.05%, halobetasol propionate 0.05%, fluocinolide 0.1%

April 18, 2021 HORMONAL AGENTS Alkindi Sprinkle hydrocortisone 5mg tablet

March 28, 2021 BLOOD PRESSURE/HEART MEDICATIONS Conjupri amlodipine, felodipine, nifedipine, nicardipine

January 1, 2021 ASTHMA/COPD/RESPIRATORY Advair HFA7, Breo Ellipta7 Dulera, fluticasone-salmeterol (generic Advair Diskus), fluticasone-salmeterol (generic Airduo), Symbicort, Wixela Inhub

ProAir HFA7, ProAir RespiClick7 albuterol HFA

Page 7: PRESCRIPTION DRUG LIST CHANGES - Cigna...NUTRITIONAL/DIETARY PreGenna, Trinaz Any generic prenatal vitamin PAIN RELIEF AND INFLAMMATORY DISEASE Amerge generic triptans (e.g. naratriptan;

VALUE FORMULARY (cont)

Generic medications start with a lowercase letter and brand name medications start with a capital letter.

Start date of change*,**

Drug classMedications that will no longer be covered^^

Generic and/or preferred brand alternatives

April 18, 2021 HORMONAL AGENTS Alkindi Sprinkle hydrocortisone 5mg tablet

January 1, 2021 CONTRACEPTION PRODUCTS Balcoltra, Natazia, Slynd, Taytulla Generic oral contraceptives (e.g. levonorgestrel-ethinyl estradiol)

DIABETES GlucaGen HypoKit7, Gvoke Baqsimi, Glucagon Emergency Kit

EYE CONDITIONS Cequa, Restasis MultiDose7, Xiidra7 Restasis

Travatan Z, Xalatan, Xelpros, Zioptan9 bimatoprost, latanoprost, travoprost

GASTROINTESTINAL/HEARTBURN Creon7, Pertzye, Zenpep7 Pancreaze

Linzess7, Motegrity, Trulance7, Zelnorm Amitiza

Sensipar cinacalcet

HORMONAL AGENTS TaperDex dexamethasone 1.5mg tablet

INFECTIONS Baraclude entecavir tablet

Noxafil tablet posaconazole DR 100mg tablet

MULTIPLE SCLEROSIS Ampyra ER7 dalfampridine ER

NUTRITIONAL/DIETARY PreGenna, Trinaz Any generic prenatal vitamin

PAIN RELIEF AND INFLAMMATORY DISEASE Amerge generic triptans (e.g. naratriptan; sumatriptan)

butalbital-acetaminophen 50-300mg tablet butalbital-acetaminophen 50-325mg tablet

Cosentyx10 Enbrel, Humira, Otezla, Skyrizi, Stelara, Taltz

diclofenac 1.3% patch, Flector 1.3% patch5, Voltaren 1% gel5

diclofenac 1% gel, generic oral NSAIDs (e.g. celecoxib; meloxicam)

Frova, Maxalt, Maxalt MLT, Relpax generic triptans (e.g. naratriptan; sumatriptan)

SEIZURE DISORDERS Felbatol11 felbamate

Keppra/Keppra XR11 levetiracetam/levetiracetam ER

Lamictal XR Start Kit11 lamotrigine ER

Lamictal/ODT/XR11 lamotrigine, lamotrigine ER, lamotrigine ODT

Qudexy XR11, Trokendi XR11 topiramate ER

Sabril11 vigabatrin, vigadrone

Topamax11 topiramate

Trileptal11 oxcarbazepine

Zonegran11 zonisamide

SKIN CONDITIONS Apexicon E5, diflorasone, Impoyz5, Olux5, Olux-E5, Psorcon

betamethasone, clobetasol, halobetasol

Condylox imiquimod 5% cream packet, podofilox 0.5% topical solution

Cordran5 betamethasone, clobetasol, fluocinolone, fluticasone, halobetasol

Page 8: PRESCRIPTION DRUG LIST CHANGES - Cigna...NUTRITIONAL/DIETARY PreGenna, Trinaz Any generic prenatal vitamin PAIN RELIEF AND INFLAMMATORY DISEASE Amerge generic triptans (e.g. naratriptan;

VALUE FORMULARY (cont)

Generic medications start with a lowercase letter and brand name medications start with a capital letter.

LEGACY (STANDARD) FORMULARY

Start date of change*,**

Drug classMedications that will no longer be covered^^

Generic and/or preferred brand alternatives

January 1, 2021 SKIN CONDITIONS Finacea foam, Finacea gel, MetroCream, MetroGel, MetroLotion, Soolantra12

azelaic acid, topical metronidazole

flurandrenolide, hydrocortisone butyrate lipid cream, lotion5, Pandel5

betamethasone, fluocinolone, fluticasone

Tridesilon5 alclometasone, desonide, triamcinolone

Xolegel ciclopirox 0.77% gel, ciclopirox 1% shampoo, ketoconazole 2% cream, ketoconazole 2% foam, selenium 2.5% lotion, sodium sulfacetamide 10% shampoo

SLEEP DISORDERS/SEDATIVES Belsomra8 DayvigoURINARY TRACT CONDITIONS Procysbi4 Cystagon

Start date of change*,**

Drug classMedications that will be excluded from coverage

Additional information

January 1, 2021 ALLERGY/NASAL SPRAYS Beconase AQ, flunisolide, mometasone, Nasonex, Omnaris, Qnasl, Qnasl Children, Xhance, Zetonna

generics products available over-the-counter (e.g. budesonide, fluticasone)

fluticasone 50 mcg spray generics products available over-the-counter (e.g. budesonide)

EYE CONDITIONS azelastine, Bepreve, epinastine, Lastacaft, Pazeo, Zerviate

products available over-the-counter (e.g. Alaway, Pataday)

SKIN CONDITIONS Rosadan Kits azelaic acid, topical metronidazole

Start date of change*,**

Drug class Medications moving to preferred brand

June 22, 2021 PAIN RELIEF AND INFLAMMATORY DISEASE Reditrex

May 15, 2021 EYE CONDITIONS Eysuvis

GASTROINTESTINAL/HEARTBURN Sutab

January 1, 2021 AIDS/HIV Juluca

ASTHMA/COPD/RESPIRATORY Bevespi

DIABETES Baqsimi

GASTROINTESTINAL/HEARTBURN pancreaze

INFECTIONS Epclusa

Harvoni

PAIN RELIEF AND INFLAMMATORY DISEASE Taltz

Start date of change*,**

Drug classMedications becoming non-preferred brand

Generic and/or preferred brand alternatives

June 29, 2021 BLOOD PRESSURE/HEART MEDICATIONS Orladeyo1 No preferred formulary drug alternatives

SKIN CONDITIONS Klisyri topical fluorouracil, imiquimod 5% cream, Fluoroplex

Page 9: PRESCRIPTION DRUG LIST CHANGES - Cigna...NUTRITIONAL/DIETARY PreGenna, Trinaz Any generic prenatal vitamin PAIN RELIEF AND INFLAMMATORY DISEASE Amerge generic triptans (e.g. naratriptan;

Generic medications start with a lowercase letter and brand name medications start with a capital letter.

LEGACY (STANDARD) FORMULARY

Start date of change*,**

Drug classMedications becoming non-preferred brand

Generic and/or preferred brand alternatives

June 22, 2021 CANCER Orgovyx1 Lupron Depot

HORMONAL AGENTS Thyquidity levothyroxine, levoxyl, Levo-T, Unithroid, Euthyrox

GASTROINTESTINAL/HEARTBURN Reltone ursodiol

June 15, 2021 GASTROINTESTINAL/HEARTBURN Lubiprostone 8 mcg, 24 mcg capsule Amitiza

June 1, 2021 SKIN CONDITIONS Winlevi 1% cream Generic products (e.g. adapalene; tretinoin; clindamycin-benzoyl peroxide)

Wynzora 0.005%-0.064% cream betamethasone DP, fluocinolone, fluticasone, mometasone, trimacinolone, calcipotriene, calcipotriene-betamethasone DP

URINARY TRACT CONDITIONS Vesicare LS 5 mg/5 mL suspension oxybutynin chloride, oxybutynin chloride ER, darifenacin ER, solifenacin, tolterodine, tolterodine ER, tropsium

May 15, 2021 EYE CONDITIONS Lacrisert Restasis, Restasis Multi-dose, Xiidra

May 2, 2021 PAIN RELIEF AND INFLAMMATORY DISEASE Qdolo tramadol

May 1, 2021 SKIN PREPS Impeklo topical betamethasone dipropionate (augmented) 0.05%, clobetasol propionate 0.05%, halobetasol propionate 0.05%, fluocinolide 0.1%

April 18, 2021 HORMONAL AGENTS Alkindi Sprinkle hydrocortisone 5mg tablet

March 28, 2021 BLOOD PRESSURE/HEART MEDICATIONS Conjupri amlodipine, felodipine, nifedipine, nicardipine

January 1, 2021 AIDS/HIV Intelence1 Talk to your doctor about other alternatives

ASTHMA/COPD/RESPIRATORY ProAir HFA, ProAir RespiClick, Ventolin HFA albuterol HFA

BLOOD MODIFIERS/BLEEDING DISORDERS Amicar 0.25 g/ml oral solution1 aminocaproic acid 0.25g/ml oral solution

BLOOD PRESSURE/HEART MEDICATIONS MULTAQ, Norpace CR 150mg Talk to your doctor about other alternatives

CANCER Tabloid Talk to your doctor about other alternatives

DIABETES Kombiglyze XR14, Onglyza14 metformin, Janumet, Janumet XR, Januvia

ERECTILE DYSFUNCTION Caverject Impulse Syringe1 MUSE

EYE CONDITIONS Lotemax 0.5% drops loteprednol 0.5% drops

Lumigan bimatoprost, latanoprost, travoprost

GASTROINTESTINAL/HEARTBURN Creon, Zenpep Pancreaze

Trulance Amitiza, Linzess

HORMONAL AGENTS Armour Thyroid, Synthroid, Unithroid levothyroxine

INFECTIONS Kitabis Pak1 tobramycin pak 300mg/5ml

MULTIPLE SCLEROSIS Ampyra ER dalfampridine ER

PAIN RELIEF AND INFLAMMATORY DISEASE Cosentyx5 Enbrel, Humira, Otezla, Skyrizi, Stelara, Taltz

SEIZURE DISORDERS Lamictal XR Start Kit lamotrigine ER

Lyrica 20mg/ml oral solution pregabalin 20mg/ml oral solution

Page 10: PRESCRIPTION DRUG LIST CHANGES - Cigna...NUTRITIONAL/DIETARY PreGenna, Trinaz Any generic prenatal vitamin PAIN RELIEF AND INFLAMMATORY DISEASE Amerge generic triptans (e.g. naratriptan;

LEGACY (STANDARD) FORMULARY (cont)

Generic medications start with a lowercase letter and brand name medications start with a capital letter.

Start date of change*,**

Drug classMedications becoming non-preferred brand

Generic and/or preferred brand alternatives

January 1, 2021 SEIZURE DISORDERS (cont) Qudexy XR, Trokendi XR topiramate ER

Sabril vigabatrin, vigadrone

SKIN CONDITIONS Finacea foam, Soolantra14 azelaic acid, topical metronidazole

Psorcon betamethasone, clobetasol, halobetasol

SLEEP DISORDERS/SEDATIVES Belsomra8 Dayvigo

SUBSTANCE ABUSE Bunavail buprenorphine/naloxone film or sublingual tablet, Zubsolv

WEIGHT MANAGEMENT Megace ES 625mg/5ml oral suspension megestrol 625ml/5ml oral suspension

Start date of change*,**

Drug class Medications that will need approval (prior authorization)^

June 29, 2021 BLOOD PRESSURE/HEART MEDICATIONS Orladeyo1

June 22, 2021 GASTROINTESTINAL/HEARTBURN Reltone

HORMONAL AGENTS Thyquidity

PAIN RELIEF AND INFLAMMATORY DISEASE Reditrex

June 15, 2021 URINARY TRACT CONDITIONS Lubiprostone 8 mcg, 24 mcg capsule

June 1, 2021 ASTHMA/COPD/RESPIRATORY Zokinvy

SKIN CONDITIONS Winlevi 1% cream

Wynzora 0.005%-0.064% cream

May 2, 2021 PAIN RELIEF AND INFLAMMATORY DISEASE Qdolo

May 1, 2021 SKIN PREPS Impeklo

April 18, 2021 HORMONAL AGENTS Alkindi Sprinkle

March 28, 2021 BLOOD PRESSURE/HEART MEDICATIONS Conjupri

March 14, 2021 CANCER Gavreto

January 1, 2021 ALLERGY/NASAL SPRAYS carbinoxamine, EpiPen, EpiPen Jr, RyVent

ANXIETY/DEPRESSION/BIPOLAR DISORDER Anafranil, Aplenzin, Ativan, Cymbalta, Lexapro, Pamelor, Parnate, Pexeva, Tofranil, Wellbutrin XL

ASTHMA/COPD/RESPIRATORY Elixophyllin, Proventil HFA, Zyflo, Zyflo CR

ATTENTION DEFICIT HYPERACTIVITY DISORDER Desoxyn, Dexedrine

BLOOD PRESSURE/HEART MEDICATIONS Betapace, Cardizem, Cardizem CD, Consensi, Isordil, Isordil Titradose, Lanoxin

BLOOD THINNERS/ANTI-CLOTTING Eliquis, Pradaxa, Savaysa, Xarelto, Yosprala

CANCER Nilandron

CHOLESTEROL MEDICATIONS Antara, Fenoglide, Lipitor

COUGH/COLD MEDICATIONS benzonatate, TussiCaps

DIABETES Fortamet, Glumetza, metformin ER Gastric, metformin ER Osmotic

DIURETICS Edecrin

EYE CONDITIONS Travatan Z, Vyzulta, Xalatan, Xelpros, Zioptan9

GASTROINTESTINAL/HEARTBURN Anusol-HC suppository, Cortifoam, Librax, Lotronex, Marinol, Motegtrity, Nexium, Omeclamox-Pak, omeprazole, Pepcid suspension, tablet, Pertzye, Prevacid SoluTab, Pylera, Rowasa, Sensipar, Uceris rectal foam, Zegerid capsule, packet, Zelnorm, Zofran, Zuplenz

HORMONAL AGENTS DDAVP nasal spray, solution, tablet, Dexpak, Rayos, TaperDex, Uceris tablet

Page 11: PRESCRIPTION DRUG LIST CHANGES - Cigna...NUTRITIONAL/DIETARY PreGenna, Trinaz Any generic prenatal vitamin PAIN RELIEF AND INFLAMMATORY DISEASE Amerge generic triptans (e.g. naratriptan;

LEGACY (STANDARD) FORMULARY (cont)

Generic medications start with a lowercase letter and brand name medications start with a capital letter.

Start date of change*,**

Drug class Medications that will need approval (prior authorization)^

January 1, 2021 INFECTIONS Augmentin, Baraclude, Diflucan, Doryx, E.E.S. 200, EryPed 400, Mepron, Minocin, Mycobutin, Noxafil tablet, Oracea, Sitavig, Solodyn, Sporanox, Targadox, Valcyte, Vancocin, Vibramycin, Zovirax capsule, suspension, tablet

MISCELLANEOUS Horizant

NUTRITIONAL/DIETARY PreGenna, Trinaz

PAIN RELIEF AND INFLAMMATORY DISEASE Allzital, Amerge, Amrix, BUPAP, Butalbital-acetaminophen 50-300mg tablet, Cambia, chlorzoxazone, ConZip, D.H.E.45, diclofenac 1.3% patch5, 1.5% topical solution, Duexis, Ergomar, Fenortho 200 mg capsule, Flector 1.3 % patch5, Frova, Gralise, Imitrex, Indocin, levorphanol, Lorzone, Maxalt, Maxalt MLT, Migranal, Naprelan, naproxen CR, Onzetra Xsail, Pennsaid, Relpax, roxicodone, Soriatane, Sprix, Tivorbex, Treximet, Vanatol LQ, Vimovo , Vivlodex, Voltaren 1% gel5, Zembrace Symtouch, Zipsor, Zomig, Zomig ZMT, Zorvolex

PARKINSON’S DISEASE Lodosyn, Requip XL, Zelapar

SCHIZOPHRENIA/ANTI-PSYCHOTICS FazaClo, Geodon, Versacloz, Zyprexa, Zyprexa Zydis

SEIZURE DISORDERS Mysoline

SKIN CONDITIONS Aldara, Anusol-HC cream, Apexicon E5, Bensal HP, Benzaclin, Carac, Clindage, Clobex shampoo, spray, topical lotion, Condylox, Cordran5, Cutivate, diclofenac 3% gel, diflorasone, Ertaczo, Exelderm, Extina, Finacea gel, flurandrenolide, Halog cream, ointment, hydrocortisone butyrate lipid cream, lotion5, Impoyz5, Jublia, Kenalog 0.147 mg/gm spray, Kerydin, Locoid, Loprox 0.77% cream, 1% shampoo, Luzu, MetroCream, MetroGel, MetroLotion, Noritate, Olux5, Olux-E5, Oxistat, Pandel5, Penlac, Prudoxin, Sernivo, Sorilux, Trainex, Tridesilon5, Ultravate, Vanos, Verdeso, Vusion, Xerese, Xolegel, Ziana, Zonalon, Zovirax cream, ointment, Zyclara

SLEEP DISORDERS/SEDATIVES Ambien, Ambien CR, Edular, Intermezzo, Nuvigil, Provigil, Restoril, Zolpimist

SUBSTANCE ABUSE EvzioStart date of change*,**

Drug class Medications that will have a quantity limit

June 29, 2021 BLOOD PRESSURE/HEART MEDICATIONS Orladeyo1

June 1, 2021 ASTHMA/COPD/RESPIRATORY Zokinvy

May 15, 2021 EYE CONDITIONS Eysuvis

May 2, 2021 PAIN RELIEF AND INFLAMMATORY DISEASE Qdolo

March 14, 2021 CANCER GavretoStart date of change*,**

Drug classMedications being added to Step Therapy Program^,^^

Generic and/or preferred brand alternatives

June 29, 2021 SKIN CONDITIONS Klisyri topical fluorouracil, imiquimod 5% cream, Fluoroplex

June 1, 2021 URINARY TRACT CONDITIONS Vesicare LS 5 mg/5 mL suspension oxybutynin chloride, oxybutynin chloride ER, darifenacin ER, solifenacin, tolterodine, tolterodine ER, tropsium

Start date of change*,**

Drug classMedications that will be excluded from coverage

Additional information

January 1, 2021 SKIN CONDITIONS Rosadan Kits azelaic acid, topical metronidazole

Page 12: PRESCRIPTION DRUG LIST CHANGES - Cigna...NUTRITIONAL/DIETARY PreGenna, Trinaz Any generic prenatal vitamin PAIN RELIEF AND INFLAMMATORY DISEASE Amerge generic triptans (e.g. naratriptan;

Generic medications start with a lowercase letter and brand name medications start with a capital letter.

PERFORMANCE FORMULARY

Start date of change*,**

Drug class Medications moving to preferred brand

June 22, 2021 PAIN RELIEF AND INFLAMMATORY DISEASE Reditrex

May 15, 2021 EYE CONDITIONS Eysuvis

GASTROINTESTINAL/HEARTBURN Sutab

April 1, 2021 CANCER Riabni

January 1, 2021 AIDS/HIV Juluca

ASTHMA/COPD/RESPIRATORY Bevespi

DIABETES Baqsimi

GASTROINTESTINAL/HEARTBURN Pancreaze

INFECTIONS Epclusa, Harvoni

PAIN RELIEF AND INFLAMMATORY DISEASE Taltz

Start date of change*,**

Drug classMedications becoming non-preferred brand

Generic and/or preferred brand alternatives

June 29, 2021 BLOOD PRESSURE/HEART MEDICATIONS Orladeyo1 Lupron Depot

June 22, 2021 CANCER Orgovyx1 No preferred formulary drug alternatives.

June 15, 2021 GASTROINTESTINAL/HEARTBURN Lubiprostone 8 mcg, 24 mcg capsule Amitiza

June 1, 2021 SKIN CONDITIONS Winlevi 1% cream Generic products (e.g. adapalene; tretinoin; clindamycin-benzoyl peroxide)

Wynzora 0.005%-0.064% cream betamethasone DP, fluocinolone, fluticasone, mometasone, trimacinolone, calcipotriene, calcipotriene-betamethasone DP

URINARY TRACT CONDITIONS Vesicare LS 5 mg/5 mL suspension oxybutynin chloride, oxybutynin chloride ER, darifenacin ER, solifenacin, tolterodine, tolterodine ER, tropsium

May 2, 2021 PAIN RELIEF AND INFLAMMATORY DISEASE Qdolo tramadol

May 1, 2021 SKIN PREPS Impeklo topical betamethasone dipropionate (augmented) 0.05%, clobetasol propionate 0.05%, halobetasol propionate 0.05%, fluocinolide 0.1%

April 18, 2021 HORMONAL AGENTS Alkindi Sprinkle hydrocortisone 5mg tablet

March 28, 2021 BLOOD PRESSURE/HEART MEDICATIONS Conjupri amlodipine, felodipine, nifedipine, nicardipine

January 1, 2021 AIDS/HIV Intelence1 Talk to your doctor about other alternatives

BLOOD PRESSURE/HEART MEDICATIONS MULTAQ Talk to your doctor about other alternatives

EYE CONDITIONS Lotemax 0.5% drops loteprednol 0.5% drops

HORMONAL AGENTS Armour Thyroid, Synthroid, Unithroid levothyroxine

INFECTIONS Kitabis Pak1 tobramycin pak 300mg/5ml

SEIZURE DISORDERS Lyrica 20mg/ml oral solution pregabalin 20mg/ml oral solution

SUBSTANCE ABUSE Bunavail buprenorphine/naloxone film or sublingual tablet, Zubsolv

Page 13: PRESCRIPTION DRUG LIST CHANGES - Cigna...NUTRITIONAL/DIETARY PreGenna, Trinaz Any generic prenatal vitamin PAIN RELIEF AND INFLAMMATORY DISEASE Amerge generic triptans (e.g. naratriptan;

PERFORMANCE FORMULARY (cont)

Generic medications start with a lowercase letter and brand name medications start with a capital letter.

Start date of change*,**

Drug classMedications becoming non-preferred brand

Generic and/or preferred brand alternatives

January 1, 2021 SUBSTANCE ABUSE Probuphine Talk to your doctor about other alternativesStart date of change*,**

Drug class Medications that will need approval (prior authorization)^

June 29, 2021 BLOOD PRESSURE/HEART MEDICATIONS Orladeyo1

June 22, 2021 PAIN RELIEF AND INFLAMMATORY DISEASE Reditrex

June 1, 2021 ASTHMA/COPD/RESPIRATORY Zokinvy

March 14, 2021 CANCER Gavreto

January 1, 2021 BLOOD THINNERS/ANTI-CLOTTING Eliquis4, Pradaxa4, Savaysa4, Xarelto4

PAIN RELIEF AND INFLAMMATORY DISEASE diclofenac 1.3% patch, Flextor 1.3% patch5, Voltaren 1% gel5

Start date of change*,**

Drug class Medications that will have a quantity limit

June 29, 2021 BLOOD PRESSURE/HEART MEDICATIONS Orladeyo1

June 1, 2021 ASTHMA/COPD/RESPIRATORY Zokinvy

May 15, 2021 EYE CONDITIONS Eysuvis

May 2, 2021 PAIN RELIEF AND INFLAMMATORY DISEASE Qdolo

March 14, 2021 CANCER GavretoStart date of change*,**

Drug classMedications that will no longer be covered^^

Generic and/or preferred brand alternatives

June 29, 2021 SKIN CONDITIONS Klisyri topical fluorouracil, imiquimod 5% cream

June 22, 2021 GASTROINTESTINAL/HEARTBURN Reltone ursodiol

HORMONAL AGENTS Thyquidity levothyroxine, levoxyl, Levo-T, Unithroid, Euthyrox

June 15, 2021 GASTROINTESTINAL/HEARTBURN Lubiprostone 8 mcg, 24 mcg capsule Amitiza

June 1, 2021 SKIN CONDITIONS Winlevi 1% cream Generic products (e.g. adapalene; tretinoin; clindamycin-benzoyl peroxide)

Wynzora 0.005%-0.064% cream betamethasone DP, fluocinolone, fluticasone, mometasone, trimacinolone, calcipotriene, calcipotriene-betamethasone DP

URINARY TRACT CONDITIONS Vesicare LS 5 mg/5 mL suspension oxybutynin chloride, oxybutynin chloride ER, darifenacin ER, solifenacin, tolterodine, tolterodine ER, tropsium

May 2, 2021 PAIN RELIEF AND INFLAMMATORY DISEASE Qdolo tramadol

May 1, 2021 SKIN PREPS Impeklo topical betamethasone dipropionate (augmented) 0.05%, clobetasol propionate 0.05%, halobetasol propionate 0.05%, fluocinolide 0.1%

April 18, 2021 HORMONAL AGENTS Alkindi Sprinkle hydrocortisone 5mg tablet

March 28, 2021 BLOOD PRESSURE/HEART MEDICATIONS Conjupri amlodipine, felodipine, nifedipine, nicardipine

Page 14: PRESCRIPTION DRUG LIST CHANGES - Cigna...NUTRITIONAL/DIETARY PreGenna, Trinaz Any generic prenatal vitamin PAIN RELIEF AND INFLAMMATORY DISEASE Amerge generic triptans (e.g. naratriptan;

PERFORMANCE FORMULARY (cont)

Generic medications start with a lowercase letter and brand name medications start with a capital letter.

Start date of change*,**

Drug classMedications that will no longer be covered^^

Generic and/or preferred brand alternatives

January 1, 2021 ASTHMA/COPD/RESPIRATORY ProAir HFA7, ProAir RespiClick7, Ventolin HFA7

albuterol HFA

DIABETES Kombiglyze XR8, Onglyza8 metformin, Janumet, Janumet XR, Januvia

EYE CONDITIONS Lumigan7, Travatan Z, Xalatan, Xelpros, Zioptan9

bimatoprost, latanoprost, travoprost

GASTROINTESTINAL/HEARTBURN Creon7, Pertzye7, Zenpep7 Pancreaze

Motegrity, Trulance7, Zelnorm Amitiza, Linzess

Sensipar cinacalcet

HORMONAL AGENTS TaperDex dexamethasone 1.5mg tablet

INFECTIONS Baraclude entecavir tablet

Noxafil tablet posaconazole DR 100mg tablet

MULTIPLE SCLEROSIS Ampyra ER7 dalfampridine ER

NUTRITIONAL/DIETARY PreGenna, Trinaz Any generic prenatal vitamin

PAIN RELIEF AND INFLAMMATORY DISEASE Amerge, Frova, Maxalt, Maxalt MLT, Relpax generic triptans (e.g. naratriptan; sumatriptan)

butalbital-acetaminophen 50-300mg tablet butalbital-acetaminophen 50-325mg tablet

Cosentyx10 Enbrel, Humira, Otezla, Skyrizi, Stelara, Taltz

SEIZURE DISORDERS Felbatol11 felbamate

Keppra/Keppra XR11 levetiracetam/levetiracetam ER

Lamictal XR Start Kit11 lamotrigine ER

Lamictal/ODT/XR11 lamotrigine, lamotrigine ER, lamotrigine ODT

Qudexy XR6, Trokendi XR11 topiramate ER

Sabril11 vigabatrin, vigadrone

Topamax11 topiramate

Trileptal11 oxcarbazepine

Zonegran11 zonisamide

SKIN CONDITIONS Apexicon E5, diflorasone, Impoyz5, Olux5, Olux-E5, Psorcon

betamethasone, clobetasol, halobetasol

Condylox imiquimod 5% cream packet, podofilox 0.5% topical solution

Cordran5 betamethasone, clobetasol, fluocinolone, fluticasone, halobetasol

Finacea7, MetroCream, MetroGel, MetroLotion, Soolantra12

azelaic acid, topical metronidazole

flurandrenolide, Pandel5 betamethasone, fluocinolone, fluticasone

hydrocortisone butyrate lipid cream, lotion5 betamethasone, fluocinolone, fluticasone

Sorilux calcitriol, tazarotene, topical calcipotriene

Page 15: PRESCRIPTION DRUG LIST CHANGES - Cigna...NUTRITIONAL/DIETARY PreGenna, Trinaz Any generic prenatal vitamin PAIN RELIEF AND INFLAMMATORY DISEASE Amerge generic triptans (e.g. naratriptan;

Generic medications start with a lowercase letter and brand name medications start with a capital letter.

ADVANTAGE FORMULARY

Start date of change*,**

Drug classMedications that will no longer be covered^^

Generic and/or preferred brand alternatives

January1, 2021 SKIN CONDITIONS (cont) Tridesilon5 alclometasone, desonide, triamcinolone

Xolegel ciclopirox 0.77% gel, ciclopirox 1% shampoo, ketoconazole 2% cream, ketoconazole 2% foam, selenium 2.5% lotion, sodium sulfacetamide 10% shampoo

SLEEP DISORDERS/SEDATIVES Belsomra8 Dayvigo

URINARY TRACT CONDITIONS Procysbi4 CystagonStart date of change*,**

Drug classMedications that will be excluded from coverage

Additional information

January 1, 2021 SKIN CONDITIONS Rosadan Kits azelaic acid, topical metronidazole

PERFORMANCE FORMULARY (cont)

Start date of change*,**

Drug class Medications moving to preferred brand

June 22, 2021 PAIN RELIEF AND INFLAMMATORY DISEASE Reditrex

May 15, 2021 EYE CONDITIONS Eysuvis

GASTROINTESTINAL/HEARTBURN Sutab

April 1, 2021 CANCER Riabni

January 1, 2021 AIDS/HIV Juluca

DIABETES Baqsimi

GASTROINTESTINAL/HEARTBURN Pancreaze

INFECTIONS Epclusa, Harvoni

PAIN RELIEF AND INFLAMMATORY DISEASE Ajovy13, Emgality13, Taltz

SEIZURE DISORDERS VIMPAT

URINARY TRACT CONDITIONS Cystagon

Start date of change*,**

Drug classMedications becoming non-preferred brand

Generic and/or preferred brand alternatives

June 29, 2021 BLOOD PRESSURE/HEART MEDICATIONS Orladeyo1 Lupron Depot

June 22, 2021 CANCER Orgovyx1 No preferred formulary drug alternatives.

June 15, 2021 GASTROINTESTINAL/HEARTBURN Lubiprostone 8 mcg, 24 mcg capsule Amitiza

June 1, 2021 SKIN CONDITIONS Winlevi 1% cream Generic products (e.g. adapalene; tretinoin; clindamycin-benzoyl peroxide)

Wynzora 0.005%-0.064% cream betamethasone DP, fluocinolone, fluticasone, mometasone, trimacinolone, calcipotriene, calcipotriene-betamethasone DP

URINARY TRACT CONDITIONS Vesicare LS 5 mg/5 mL suspension oxybutynin chloride, oxybutynin chloride ER, darifenacin ER, solifenacin, tolterodine, tolterodine ER, tropsium

May 2, 2021 PAIN RELIEF AND INFLAMMATORY DISEASE Qdolo tramadol

Page 16: PRESCRIPTION DRUG LIST CHANGES - Cigna...NUTRITIONAL/DIETARY PreGenna, Trinaz Any generic prenatal vitamin PAIN RELIEF AND INFLAMMATORY DISEASE Amerge generic triptans (e.g. naratriptan;

ADVANTAGE FORMULARY (cont)

Generic medications start with a lowercase letter and brand name medications start with a capital letter.

Start date of change*,**

Drug classMedications becoming non-preferred brand

Generic and/or preferred brand alternatives

June 29, 2021 BLOOD PRESSURE/HEART MEDICATIONS Orladeyo1 Lupron Depot

May 1, 2021 SKIN PREPS Impeklo topical betamethasone dipropionate (augmented) 0.05%, clobetasol propionate 0.05%, halobetasol propionate 0.05%, fluocinolide 0.1%

April 18, 2021 HORMONAL AGENTS Alkindi Sprinkle hydrocortisone 5mg tablet

March 28, 2021 BLOOD PRESSURE/HEART MEDICATIONS Conjupri amlodipine, felodipine, nifedipine, nicardipine

January 1, 2021 AIDS/HIV Intelence1 Talk to your doctor about other alternatives

HORMONAL AGENTS Unithroid 75mcg tablet levothyroxine

INFECTIONS Kitabis Pak1 tobramycin pak 300mg/5ml

SEIZURE DISORDERS Lyrica 20mg/ml oral solution pregabalin 20mg/ml oral solution

SUBSTANCE ABUSE Bunavail buprenorphine/naloxone film or sublingual tablet, Zubsolv

Probuphine Talk to your doctor about other alternatives

WEIGHT MANAGEMENT Megace ES 625mg/5ml oral suspension megestrol 625ml/5ml oral suspension

Start date of change*,**

Drug class Medications that will need approval (prior authorization)^

June 29, 2021 BLOOD PRESSURE/HEART MEDICATIONS Orladeyo1

June 22, 2021 PAIN RELIEF AND INFLAMMATORY DISEASE Reditrex

June 1, 2021 ASTHMA/COPD/RESPIRATORY Zokinvy

March 14, 2021 CANCER Gavreto

January 1, 2021 BLOOD THINNERS/ANTI-CLOTTING Eliquis4, Pradaxa4, Savaysa4, Xarelto4

HORMONAL AGENTS Tirosint, Tirosint-SOL

Start date of change*,**

Drug class Medications that will have a quantity limit

June 29, 2021 BLOOD PRESSURE/HEART MEDICATIONS Orladeyo1

June 1, 2021 ASTHMA/COPD/RESPIRATORY Zokinvy

May 15, 2021 EYE CONDITIONS Eysuvis

May 2, 2021 PAIN RELIEF AND INFLAMMATORY DISEASE Qdolo

March 14, 2021 CANCER Gavreto

Start date of change*,**

Drug classMedications that will no longer be covered^^

Generic and/or preferred brand alternatives

June 29, 2021 SKIN CONDITIONS Klisyri topical fluorouracil, imiquimod 5% cream

June 22, 2021 GASTROINTESTINAL/HEARTBURN Reltone ursodiol

HORMONAL AGENTS Thyquidity levothyroxine, levoxyl, Levo-T, Unithroid, Euthyrox

June 15, 2021 GASTROINTESTINAL/HEARTBURN Lubiprostone 8 mcg, 24 mcg capsule Amitiza

June 1, 2021 SKIN CONDITIONS Winlevi 1% cream Generic products (e.g. adapalene; tretinoin; clindamycin-benzoyl peroxide)

Page 17: PRESCRIPTION DRUG LIST CHANGES - Cigna...NUTRITIONAL/DIETARY PreGenna, Trinaz Any generic prenatal vitamin PAIN RELIEF AND INFLAMMATORY DISEASE Amerge generic triptans (e.g. naratriptan;

ADVANTAGE FORMULARY (cont)

Generic medications start with a lowercase letter and brand name medications start with a capital letter.

Start date of change*,**

Drug classMedications that will no longer be covered^^

Generic and/or preferred brand alternatives

June 1, 2021 SKIN CONDITIONS (cont) Wynzora 0.005%-0.064% cream betamethasone DP, fluocinolone, fluticasone, mometasone, trimacinolone, calcipotriene, calcipotriene-betamethasone DP

URINARY TRACT CONDITIONS Vesicare LS 5 mg/5 mL suspension oxybutynin chloride, oxybutynin chloride ER, darifenacin ER, solifenacin, tolterodine, tolterodine ER, tropsium

May 2, 2021 PAIN RELIEF AND INFLAMMATORY DISEASE Qdolo tramadol

May 1, 2021 SKIN PREPS Impeklo topical betamethasone dipropionate (augmented) 0.05%, clobetasol propionate 0.05%, halobetasol propionate 0.05%, fluocinolide 0.1%

April 18, 2021 HORMONAL AGENTS Alkindi Sprinkle hydrocortisone 5mg tablet

March 28, 2021 BLOOD PRESSURE/HEART MEDICATIONS Conjupri amlodipine, felodipine, nifedipine, nicardipine

January 1, 2021 ASTHMA/COPD/RESPIRATORY Advair HFA7, Breo Ellipta7 Dulera, fluticasone-salmeterol (generic Advair Diskus), fluticasone-salmeterol (generic Airduo), Symbicort, Wixela Inhub

ProAir HFA7, ProAir RespiClick7 albuterol HFA

CONTRACEPTION PRODUCTS Balcoltra, Natazia, Slynd, Taytulla Generic oral contraceptives (e.g. levonorgestrel-ethinyl estradiol)

DIABETES GlucaGen HypoKit7, Gvoke Baqsimi, Glucagon Emergency Kit

EYE CONDITIONS Cequa, Restasis MultiDose7, Xiidra7 Restasis

Travatan Z, Xalatan, Xelpros, Zioptan9 bimatoprost, latanoprost, travoprost

GASTROINTESTINAL/HEARTBURN Creon7, Pertzye, Zenpep7 Pancreaze

Linzess7, Motegrity, Trulance7, Zelnorm Amitiza

Sensipar cinacalcet

HORMONAL AGENTS TaperDex dexamethasone 1.5mg tablet

INFECTIONS Baraclude entecavir tablet

Noxafil tablet posaconazole DR 100mg tablet

MULTIPLE SCLEROSIS Ampyra ER7 dalfampridine ER

NUTRITIONAL/DIETARY PreGenna, Trinaz Any generic prenatal vitamin

PAIN RELIEF AND INFLAMMATORY DISEASE Amerge generic triptans (e.g. naratriptan; sumatriptan)

butalbital-acetaminophen 50-300mg tablet butalbutal-acetaminophen 50-325mg tablet

Cosentyx10 Enbrel, Humira, Otezla, Skyrizi, Stelara, Taltz

diclofenac 1.3% patch, Flector 1.3% patch5, Voltaren 1% gel5

diclofenac 1% gel, generic oral NSAIDs (e.g. celecoxib; meloxicam)

Page 18: PRESCRIPTION DRUG LIST CHANGES - Cigna...NUTRITIONAL/DIETARY PreGenna, Trinaz Any generic prenatal vitamin PAIN RELIEF AND INFLAMMATORY DISEASE Amerge generic triptans (e.g. naratriptan;

ADVANTAGE FORMULARY (cont)

Generic medications start with a lowercase letter and brand name medications start with a capital letter.

Start date of change*,**

Drug classMedications that will no longer be covered^^

Generic and/or preferred brand alternatives

January 1, 2021 PAIN RELIEF AND INFLAMMATORY DISEASE (cont)

Frova, Maxalt, Maxalt MLT, Relpax generic triptans (e.g. naratriptan; sumatriptan)

SEIZURE DISORDERS Felbatol11 felbamate

Keppra/Keppra XR11 levetiracetam/levetiracetam ER

Lamictal XR Start Kit11 lamotrigine ER

Lamictal/ODT/XR11 lamotrigine, lamotrigine ER, lamotrigine ODT

Qudexy XR5, Trokendi XR11 topiramate ER

Sabril11 vigabatrin, vigadrone

Topamax11 topiramate

Trileptal11 oxcarbazepine

Zonegran11 zonisamide

SKIN CONDITIONS Apexicon E5, diflorasone, Impoyz5, Olux5, Olux-E5, Psorcon

betamethasone, clobetasol, halobetasol

Condylox imiquimod 5% cream packet, podofilox 0.5% topical solution

Cordran5 betamethasone, clobetasol, fluocinolone, fluticasone, halobetasol

Finacea, MetroCream, MetroGel, MetroLotion, Soolantra12

azelaic acid, topical metronidazole

flurandrenolide, hydrocortisone butyrate lipid cream, lotion5, Pandel5

betamethasone, fluocinolone, fluticasone

Tridesilon5 alclometasone, desonide, triamcinolone

Xolegel ciclopirox 0.77% gel, ciclopirox 1% shampoo, ketoconazole 2% cream, ketoconazole 2% foam, selenium 2.5% lotion, sodium sulfacetamide 10% shampoo

SLEEP DISORDERS/SEDATIVES Belsomra8 Dayvigo

URINARY TRACT CONDITIONS Procysbi4 CystagonStart date of change*,**

Drug classMedications that will be excluded from coverage

Additional information

January 1, 2021 ALLERGY/NASAL SPRAYS Beconase AQ, flunisolide, mometasone, Nasonex, Omnaris, Qnasl, Qnasl Children, Xhance, Zetonna

generics products available over-the-counter (e.g. budesonide, fluticasone)

EYE CONDITIONS azelastine, Bepreve, epinastine, Lastacaft, Pazeo, Zerviate

products available over-the-counter (e.g. Alaway, Pataday)

SKIN CONDITIONS Rosadan Kits azelaic acid, topical metronidazole

Page 19: PRESCRIPTION DRUG LIST CHANGES - Cigna...NUTRITIONAL/DIETARY PreGenna, Trinaz Any generic prenatal vitamin PAIN RELIEF AND INFLAMMATORY DISEASE Amerge generic triptans (e.g. naratriptan;

Generic medications start with a lowercase letter and brand name medications start with a capital letter.

LEGACY (PERFORMANCE) FORMULARY

Start date of change*,**

Drug class Medications moving to preferred brand

June 22, 2021 PAIN RELIEF AND INFLAMMATORY DISEASE Reditrex

May 15, 2021 EYE CONDITIONS Eysuvis

GASTROINTESTINAL/HEARTBURN Sutab

April 1, 2021 CANCER Riabni

January 1, 2021 AIDS/HIV Juluca

ASTHMA/COPD/RESPIRATORY Bevespi

DIABETES Baqsimi

GASTROINTESTINAL/HEARTBURN Pancreaze

INFECTIONS Epclusa, Harvoni

PAIN RELIEF AND INFLAMMATORY DISEASE Taltz

Start date of change*,**

Drug classMedications becoming non-preferred brand

Generic and/or preferred brand alternatives

June 29, 2021 BLOOD PRESSURE/HEART MEDICATIONS Orladeyo1 No preferred formulary drug alternatives

SKIN CONDITIONS Klisyri topical fluorouracil, imiquimod 5% cream, Fluoroplex

June 22, 2021 CANCER Orgovyx1 Lupron Depot

HORMONAL AGENTS Thyquidity levothyroxine, levoxyl, Levo-T, Unithroid, Euthyrox

GASTROINTESTINAL/HEARTBURN Reltone ursodiol

June 15, 2021 GASTROINTESTINAL/HEARTBURN Lubiprostone 8 mcg, 24 mcg capsule Amitiza

June 1, 2021 SKIN CONDITIONS Winlevi 1% cream Generic products (e.g. adapalene; tretinoin; clindamycin-benzoyl peroxide)

Wynzora 0.005%-0.064% cream betamethasone DP, fluocinolone, fluticasone, mometasone, trimacinolone, calcipotriene, calcipotriene-betamethasone DP

URINARY TRACT CONDITIONS Vesicare LS 5 mg/5 mL suspension oxybutynin chloride, oxybutynin chloride ER, darifenacin ER, solifenacin, tolterodine, tolterodine ER, tropsium

May 2, 2021 PAIN RELIEF AND INFLAMMATORY DISEASE Qdolo tramadol

May 1, 2021 SKIN PREPS Impeklo topical betamethasone dipropionate (augmented) 0.05%, clobetasol propionate 0.05%, halobetasol propionate 0.05%, fluocinolide 0.1%

April 18, 2021 HORMONAL AGENTS Alkindi Sprinkle hydrocortisone 5mg tablet

March 28, 2021 BLOOD PRESSURE/HEART MEDICATIONS Conjupri amlodipine, felodipine, nifedipine, nicardipine

January 1, 2021 AIDS/HIV Intelence1 Talk to your doctor about other alternatives

ASTHMA/COPD/RESPIRATORY ProAir HFA, ProAir RespiClick, Ventolin HFA albuterol HFA

BLOOD PRESSURE/HEART MEDICATIONS MULTAQ Talk to your doctor about other alternatives

Page 20: PRESCRIPTION DRUG LIST CHANGES - Cigna...NUTRITIONAL/DIETARY PreGenna, Trinaz Any generic prenatal vitamin PAIN RELIEF AND INFLAMMATORY DISEASE Amerge generic triptans (e.g. naratriptan;

LEGACY (PERFORMANCE) FORMULARY (cont)

Generic medications start with a lowercase letter and brand name medications start with a capital letter.

Start date of change*,**

Drug classMedications becoming non-preferred brand

Generic and/or preferred brand alternatives

January 1, 2021 DIABETES Kombiglyze XR14, Onglyza14 metformin, Janumet, Janumet XR, Januvia

EYE CONDITIONS Lotemax 0.5% drops loteprednol 0.5% drops

Lumigan bimatoprost, latanoprost, travoprost

GASTROINTESTINAL/HEARTBURN Creon, Zenpep Pancreaze

Trulance Amitiza, Linzess

HORMONAL AGENTS Armour Thyroid, Synthroid, Unithroid 75mcg tablet

levothyroxine

INFECTIONS Kitabis Pak1 tobramycin pak 300mg/5ml

MULTIPLE SCLEROSIS Ampyra ER dalfampridine ER

PAIN RELIEF AND INFLAMMATORY DISEASE Cosentyx1,4 Enbrel, Humira, Otezla, Skyrizi, Stelara, Taltz

SEIZURE DISORDERS Lamictal XR Start Kit lamotrigine ER

Lyrica 20mg/ml oral solution pregabalin 20mg/ml oral solution

Qudexy XR, Trokendi XR topiramate ER

Sabril1 vigabatrin, vigadrone

SKIN CONDITIONS Finacea foam, Soolantra14 azelaic acid, topical metronidazole

Psorcon betamethasone, clobetasol, halobetasol

SLEEP DISORDERS/SEDATIVES Belsomra8 Dayvigo

SUBSTANCE ABUSE Bunavail buprenorphine/naloxone film or sublingual tablet, Zubsolv

Probuphine Talk to your doctor about other alternatives

WEIGHT MANAGEMENT Megace ES 625mg/5ml oral suspension megestrol 625ml/5ml oral suspension

Start date of change*,**

Drug class Medications that will need approval (prior authorization)^

June 29, 2021 BLOOD PRESSURE/HEART MEDICATIONS Orladeyo1

June 22, 2021 GASTROINTESTINAL/HEARTBURN Reltone

HORMONAL AGENTS Thyquidity

PAIN RELIEF AND INFLAMMATORY DISEASE Reditrex

June 15, 2021 GASTROINTESTINAL/HEARTBURN Lubiprostone 8 mcg, 24 mcg capsule

June 1, 2021 ASTHMA/COPD/RESPIRATORY Zokinvy

SKIN CONDITIONS Winlevi 1% cream

Wynzora 0.005%-0.064% cream

May 2, 2021 PAIN RELIEF AND INFLAMMATORY DISEASE Qdolo

May 1, 2021 SKIN PREPS Impeklo

April 18, 2021 HORMONAL AGENTS Alkindi Sprinkle

March 28, 2021 BLOOD PRESSURE/HEART MEDICATIONS Conjupri

March 14, 2021 CANCER Gavreto

Page 21: PRESCRIPTION DRUG LIST CHANGES - Cigna...NUTRITIONAL/DIETARY PreGenna, Trinaz Any generic prenatal vitamin PAIN RELIEF AND INFLAMMATORY DISEASE Amerge generic triptans (e.g. naratriptan;

LEGACY (PERFORMANCE) FORMULARY (cont)

Generic medications start with a lowercase letter and brand name medications start with a capital letter.

Start date of change*,**

Drug class Medications that will need approval (prior authorization)^

January 1, 2021 ANXIETY/DEPRESSION/BIPOLAR DISORDER Anafranil, Aplenzin, Ativan, Cymbalta, Lexapro, Pamelor, Parnate, Pexeva, Tofranil, Wellbutrin XL

ASTHMA/COPD/RESPIRATORY Elixophyllin, Proventil HFA, Zyflo, Zyflo CR

ATTENTION DEFICIT HYPERACTIVITY DISORDER Desoxyn, Dexedrine

BLOOD PRESSURE/HEART MEDICATIONS Betapace, Cardizem, Cardizem CD, Consensi, Isordil, Isordil Titradose, Lanoxin

BLOOD THINNERS/ANTI-CLOTTING Eliquis, Pradaxa, Savaysa, Xarelto, Yosprala

CANCER Aldara, Nilandron, Zyclara

CHOLESTEROL MEDICATIONS Antara, Fenoglide, Lipitor

COUGH/COLD MEDICATIONS benzonatate, TussiCaps

DIABETES Fortamet, Glumetza, metformin ER Gastric, metformin ER Osmotic

DIURETICS Edecrin

EYE CONDITIONS Travatan Z, Vyzulta, Xalatan, Xelpros, Zioptan9

GASTROINTESTINAL/HEARTBURN Anusol-HC suppository, Cortifoam, Librax, Lotronex, Marinol, Motegrity, Nexium, Omeclamox-Pak, omeprazole, Pepcid suspension, tablet, Pertzye, Prevacid SoluTab, Pylera, Rowasa, Sensipar, Uceris rectal foam, Zegerid capsule, packet, Zelnorm, Zofran, Zuplenz

HORMONAL AGENTS DDAVP nasal spray, solution, tablet, Dexpak, Rayos, TaperDex, Uceris tablet

INFECTIONS Augmentin, Baraclude, Diflucan, Doryx, E.E.S. 200 EryPed 400, Mepron, Minocin, Mycobutin, Noxafil tablet, Oracea, Sitavig, Solodyn, Sporanox, Targadox, Valcyte, Vancocin, Vibramycin, Zovirax capsule, suspension, tablet

MISCELLANEOUS Horizant

NUTRITIONAL/DIETARY PreGenna, Trinaz

PAIN RELIEF AND INFLAMMATORY DISEASE Allzital, Amerge, Amrix, BUPAP, butalbital-acetaminophen 50-300mg tablet, Cambia, chlorzoxazone, ConZip, D.H.E.45, diclofenac 1.3% patch5, 1.5% topical solution, Duexis, Ergomar, Fenortho 200 mg capsule, Flector 1.3% patch5, Frova, Gralise, Imitrex, Indocin, levorphanol, Lorzone, Maxalt, Maxalt MLT, Migranal, Naprelan, naproxen CR, Onzetra Xsail, Pennsaid, Relpax, Roxicodone, Soriatane, Sprix, Tivorbex, Treximet, Vanatol LQ, Vimovo, Vivlodex, Votaren 1% gel5, Zembrace Symtouch, Zipsor, Zomig, Zomig ZMT, Zorvolex

PARKINSON'S DISEASE Lodosyn, Requip XL, Zelapar

SCHIZOPHRENIA/ANTI-PSYCHOTICS FazaClo, Geodon, Versacloz, Zyprexa, Zyprexa Zydis

SEIZURE DISORDERS Mysoline

SKIN CONDITIONS Anusol-HC cream, Apexicon E5, Bensal HP, Benzaclin, Carac, Clindagel, Clobex shampoo, spray, topical lotion, Condylox, Cordran5, Cutivate, diclofenac 3% gel, diflorasone, Ertaczo, Exelderm, Extina, Finacea gel, flurandrenolide, Halog cream, ointment, hydrocortisone butyrate lipid cream, lotion5, Impoyz5, Jublia, Kenalog 0.147mg/gm spray, Kerydin, Locoid, Loprox 0.77% cream, 1% shampoo, Luzu, MetroCream, MetroGel, MetroLotion, Noritate, Olux5, Olux-E5, Oxistat, Pandel5, Penlac, Prudoxin, Sernivo, Sorilux, Trainex, Tridesilon2, Ultravate, Vanos, Verdeso, Vusion, Xerese, Xolegel, Ziana, Zonalon, Zovirax cream, ointment

SLEEP DISORDERS/SEDATIVES Ambien, Ambien CR, Edular, Intermezzo, Nuvigil, Provigil, Restoril, Zolpimist

Page 22: PRESCRIPTION DRUG LIST CHANGES - Cigna...NUTRITIONAL/DIETARY PreGenna, Trinaz Any generic prenatal vitamin PAIN RELIEF AND INFLAMMATORY DISEASE Amerge generic triptans (e.g. naratriptan;

LEGACY (PERFORMANCE) FORMULARY (cont)

CIGNA TOTAL SAVINGS FORMULARY

Generic medications start with a lowercase letter and brand name medications start with a capital letter.

Start date of change*,**

Drug class Medications that will need approval (prior authorization)^

January 1, 2021 SUBSTANCE ABUSE Evzio

Start date of change*,**

Drug class Medications that will have a quantity limit

June 29, 2021 BLOOD PRESSURE/HEART MEDICATIONS Orladeyo1

June 1, 2021 ASTHMA/COPD/RESPIRATORY Zokinvy

May 15, 2021 EYE CONDITIONS Eysuvis

May 2, 2021 PAIN RELIEF AND INFLAMMATORY DISEASE Qdolo

March 14, 2021 CANCER Gavreto

Start date of change*,**

Drug classMedications being added to Step Therapy Program^,^^

Generic and/or preferred brand alternatives

June 29, 2021 SKIN CONDITIONS Klisyri topical fluorouracil, imiquimod 5% cream, Fluoroplex

June 1, 2021 URINARY TRACT CONDITIONS Vesicare LS 5 mg/5 mL suspension oxybutynin chloride, oxybutynin chloride ER, darifenacin ER, solifenacin, tolterodine, tolterodine ER, tropsium

Start date of change*,**

Drug classMedications that will be excluded from coverage

Additional information

January 1, 2021 SKIN CONDITIONS Rosadan Kits azelaic acid, topical metronidazole

Start date of change*,**

Drug class Medications moving to preferred brand

June 22, 2021 PAIN RELIEF AND INFLAMMATORY DISEASE Reditrex

May 15, 2021 EYE CONDITIONS Eysuvis

GASTROINTESTINAL/HEARTBURN Sutab

January 1, 2021 AIDS/HIV Juluca

DIABETES Baqsimi

Jentadueto15, Jentadueto XR15, Tradjenta15

GASTROINTESTINAL/HEARTBURN Pancreaze

HORMONAL AGENTS Imvexxy, Intrarosa

INFECTIONS Epclusa, Harvoni

PAIN RELIEF AND INFLAMMATORY DISEASE Ajovy13, Cimzia, Emgality13, Olumiant

SEIZURE DISORDERS VIMPAT

URINARY TRACT CONDITIONS Cystagon

Start date of change*,**

Drug classMedications becoming non-preferred brand

Generic and/or preferred brand alternatives

June 29, 2021 BLOOD PRESSURE/HEART MEDICATIONS Orladeyo1 Lupron Depot

June 22, 2021 CANCER Orgovyx1 No preferred formulary drug alternatives.

Page 23: PRESCRIPTION DRUG LIST CHANGES - Cigna...NUTRITIONAL/DIETARY PreGenna, Trinaz Any generic prenatal vitamin PAIN RELIEF AND INFLAMMATORY DISEASE Amerge generic triptans (e.g. naratriptan;

CIGNA TOTAL SAVINGS FORMULARY (cont)

Generic medications start with a lowercase letter and brand name medications start with a capital letter.

Start date of change*,**

Drug classMedications becoming non-preferred brand

Generic and/or preferred brand alternatives

June 15, 2021 GASTROINTESTINAL/HEARTBURN Lubiprostone 8 mcg, 24 mcg capsule Amitiza

June 1, 2021 SKIN CONDITIONS Winlevi 1% cream Generic products (e.g. adapalene; tretinoin; clindamycin-benzoyl peroxide)

Wynzora 0.005%-0.064% cream betamethasone DP, fluocinolone, fluticasone, mometasone, trimacinolone, calcipotriene, calcipotriene-betamethasone DP

URINARY TRACT CONDITIONS Vesicare LS 5 mg/5 mL suspension oxybutynin chloride, oxybutynin chloride ER, darifenacin ER, solifenacin, tolterodine, tolterodine ER, tropsium

May 2, 2021 PAIN RELIEF AND INFLAMMATORY DISEASE Qdolo tramadol

May 1, 2021 SKIN PREPS Impeklo topical betamethasone dipropionate (augmented) 0.05%, clobetasol propionate 0.05%, halobetasol propionate 0.05%, fluocinolide 0.1%

April 18, 2021 HORMONAL AGENTS Alkindi Sprinkle hydrocortisone 5mg tablet

March 28, 2021 BLOOD PRESSURE/HEART MEDICATIONS Conjupri amlodipine, felodipine, nifedipine, nicardipine

January 1, 2021 AIDS/HIV Atripla1, Descovy1, Intelence1, Selzentry1, Symtuza1, Truvada1

Talk to your doctor about other alternatives

ERECTILE DYSFUNCTION Caverject Impulse Syringe Talk to your doctor about other alternatives

INFECTIONS Kitabis Pak1 tobramycin pak 300mg/5ml

SEIZURE DISORDERS Lyrica 20mg/ml oral solution pregabalin 20mg/ml oral solution

SUBSTANCE ABUSE Bunavail buprenorphine/naloxone film or sublingual tablet, Zubsolv

WEIGHT MANAGEMENT Megace ES 625mg/5ml oral suspension megestrol 625ml/5ml oral suspension

Start date of change*,**

Drug class Medications that will need approval (prior authorization)^

June 29, 2021 BLOOD PRESSURE/HEART MEDICATIONS Orladeyo1

June 22, 2021 PAIN RELIEF AND INFLAMMATORY DISEASE Reditrex

June 1, 2021 ASTHMA/COPD/RESPIRATORY Zokinvy

March 14, 2021 CANCER Gavreto

January 1, 2021 BLOOD THINNERS/ANTI-CLOTTING Eliquis4, Pradaxa4, Savaysa4, Xarelto4

Start date of change*,**

Drug class Medications that will have a quantity limit

June 29, 2021 BLOOD PRESSURE/HEART MEDICATIONS Orladeyo1

June 1, 2021 ASTHMA/COPD/RESPIRATORY Zokinvy

May 15, 2021 EYE CONDITIONS Eysuvis

May 2, 2021 PAIN RELIEF AND INFLAMMATORY DISEASE Qdolo

March 14, 2021 CANCER Gavreto

Start date of change*,**

Drug classMedications being added to Step Therapy Program^,^^

Generic and/or preferred brand alternatives

July 1, 2021 DIABETES Jentadueto, Jentadueto XR, Tradjenta metformin

Page 24: PRESCRIPTION DRUG LIST CHANGES - Cigna...NUTRITIONAL/DIETARY PreGenna, Trinaz Any generic prenatal vitamin PAIN RELIEF AND INFLAMMATORY DISEASE Amerge generic triptans (e.g. naratriptan;

Generic medications start with a lowercase letter and brand name medications start with a capital letter.

CIGNA TOTAL SAVINGS FORMULARY (cont)

Start date of change*,**

Drug classMedications that will no longer be covered^^

Generic and/or preferred brand alternatives

June 29, 2021 SKIN CONDITIONS Klisyri topical fluorouracil, imiquimod 5% cream, Fluoroplex

June 22, 2021 GASTROINTESTINAL/HEARTBURN Reltone ursodiol

HORMONAL AGENTS Thyquidity levothyroxine, levoxyl, Levo-T, Unithroid, Euthyrox

June 15, 2021 GASTROINTESTINAL/HEARTBURN Lubiprostone 8 mcg, 24 mcg capsule Amitiza

June 1, 2021 SKIN CONDITIONS Winlevi 1% cream Generic products (e.g. adapalene; tretinoin; clindamycin-benzoyl peroxide)

Wynzora 0.005%-0.064% cream betamethasone DP, fluocinolone, fluticasone, mometasone, trimacinolone, calcipotriene, calcipotriene-betamethasone DP

URINARY TRACT CONDITIONS Vesicare LS 5 mg/5 mL suspension oxybutynin chloride, oxybutynin chloride ER, darifenacin ER, solifenacin, tolterodine, tolterodine ER, tropsium

May 2, 2021 PAIN RELIEF AND INFLAMMATORY DISEASE Qdolo tramadol

May 1, 2021 SKIN PREPS Impeklo topical betamethasone (augmented) 0.05%, clobetasol 0.05%, halobetasol propionate 0.05%, fluocinolide 0.1%

April 18, 2021 HORMONAL AGENTS Alkindi Sprinkle hydrocortisone 5mg tablet

March 28, 2021 BLOOD PRESSURE/HEART MEDICATIONS Conjupri amlodipine, felodipine, nifedipine, nicardipine

January 1, 2021 ANXIETY/DEPRESSION/BIPOLAR DISORDER Forfivo XL bupropion XL tablet

Paxil CR paroxetine ER

ASTHMA/COPD/RESPIRATORY Advair HFA7, Breo Ellipta7 Dulera, fluticasone-salmeterol (generic Advair Diskus), fluticasone-salmeterol (generic Airduo), Symbicort, Wixela Inhub

Kalydeco5, Orkambi5, Symdeko5 Trikafta3

ProAir HFA7, ProAir RespiClick7 albuterol HFA

ATTENTION DEFICIT HYPERACTIVITY DISORDER Intuniv guanfacine ER

Strattera atomoxetine capsule

BLOOD PRESSURE/HEART MEDICATIONS Ranexa ranolazine ER

CANCER Pomalyst5 Revlimid

CHOLESTEROL MEDICATIONS Lovaza omega-3 acid ethyl esters capsule

CONTRACEPTION PRODUCTS Balcoltra, Loseasonique, Natazia, Quartette, Slynd, Taytulla7

Generic oral contraceptives (e.g. levonorgestrel-ethinyl estradiol)

Beyaz, Safyral, Yasmin 28, Yaz Generic oral contraceptives (e.g. drospirenone-ethinyl estradiol-levomefolate)

Depo-Provera medroxyprogesterone

Estrostep FE Generic oral contraceptives (e.g. Tilia FE, Tri-Legest FE)

Page 25: PRESCRIPTION DRUG LIST CHANGES - Cigna...NUTRITIONAL/DIETARY PreGenna, Trinaz Any generic prenatal vitamin PAIN RELIEF AND INFLAMMATORY DISEASE Amerge generic triptans (e.g. naratriptan;

CIGNA TOTAL SAVINGS FORMULARY (cont)

Generic medications start with a lowercase letter and brand name medications start with a capital letter.

Start date of change*,**

Drug classMedications that will no longer be covered^^

Generic and/or preferred brand alternatives

January 1, 2021 CONTRACEPTION PRODUCTS Generess FE, Layolis FE, Loestrin FE, Miastrin 24 FE

Generic oral contraceptives (e.g. norethindrone-ethinyl estradiol-FE)

Loestrin Generic oral contraceptives (e.g. norethindrone-ethinyl estradiol)

Mirapex ER 4.5mg tablet pramipexole ER 4.5mg tablet

NuvaRing etonogestrel-ethinyl estradiol vaginal ring

Ortho Micronor Generic oral contraceptives (e.g. norethindrone 0.35mg)

Prenatabas FA Pretab 29mg-1mg tablet

DIABETES GlucaGen HypoKit7, Gvoke Baqsimi, Glucagon Emergency Kit

Janumet8, Janumet XR8, Januvia8 metformin, Jentadueto, Jentadueto XR, Tradjenta

EYE CONDITIONS Cequa, Restasis MultiDose7, Xiidra7 Restasis

FML Liquifilm fluorometholone eye drops

Lotemax drops loteprednol 0.5% drops

Travatan Z, Xalatan, Xelpros, Zioptan9 bimatoprost, latanoprost, travoprost

GASTROINTESTINAL/HEARTBURN Apriso mesalamine ER capsule

Carafate7 sucralfate

Creon7, Pertzye, Zenpep7 Pancreaze

Linzess7, Motegrity, Trulance7, Zelnorm Amitiza

Sensipar cinacalcet

HORMONAL AGENTS Armour Thyroid, Synthroid7, Tirosint, Tirosint Sol, Unithroid7

levothyroxine

Cortef hydrocortisone tablet

Minivelle estradiol patch

TaperDex dexamethasone 1.5mg tablet

Vivelle-Dot estradiol patch

INFECTIONS Baraclude entecavir tablet

Noxafil tablet posaconazole DR 100mg tablet

Sulfatrim sulfamethoxazole-TMP suspension

Tamiflu oseltamivir

MULTIPLE SCLEROSIS Ampyra ER7 dalfampridine ER

Avonex7, Extavia7, Plegridy7, Rebif7 Betaseron, glatiramer, Glatopa

Gilenya7, Mavenclad, Mayzent7, Tecfidera7, Zeposia7

Vumerity

NUTRITIONAL/DIETARY PreGenna, Trinaz Any generic prenatal vitamin

VitaTrue Combo Pack Prena1 True Combo Pack

PAIN RELIEF AND INFLAMMATORY DISEASE Amerge, Frova, Maxalt, Maxalt MLT, Relpax generic triptans (e.g. naratriptan; sumatriptan)

Page 26: PRESCRIPTION DRUG LIST CHANGES - Cigna...NUTRITIONAL/DIETARY PreGenna, Trinaz Any generic prenatal vitamin PAIN RELIEF AND INFLAMMATORY DISEASE Amerge generic triptans (e.g. naratriptan;

Generic medications start with a lowercase letter and brand name medications start with a capital letter.

CIGNA TOTAL SAVINGS FORMULARY (cont)

Start date of change*,**

Drug classMedications that will no longer be covered^^

Generic and/or preferred brand alternatives

January 1, 2021 PAIN RELIEF AND INFLAMMATORY DISEASE (cont)

butalbital-acetaminophen 50-300mg tablet butalbutal-acetaminophen 50-325mg tablet

diclofenac 1.3% patch, Flector 1.3% patch3,5, Voltaren 1% gel5

diclofenac 1% gel, oral generic Rx NSAIDs (e.g. celecoxib; meloxicam)

Humira7 Actemra, Cimzia, Cosentyx, Enbrel, Simponi 100mg, Stelara, Tremfya

Ilumya7, Otezla7, Skyrizi7 Cimzia, Cosentyx, Enbrel, Olumiant, Stelara, Tremfya

Kevzara, Rinvoq7 Actemra, Cimzia, Enbrel, Olumiant

Orencia Actemra, Cimzia, Cosentyx, Enbrel, Olumiant, Stelara

Uloric febuxostat

Xeljanz7, Xeljanz XR7 Actemra, Cimzia, Cosentyx, Enbrel, Olumiant, Simponi 100mg, Stelara

SEIZURE DISORDERS Carbatrol, Tegretol XR carbamazepine ER capsule

Depakote divalproex

Depakote ER divalproex ER

Depakote Sprinkle divalproex DR sprinkle capsule

Felbatol11 felbamate

Keppra/Keppra X11 levetiracetam/levetiracetam ER

Lamictal XR Start Kit11 lamotrigine ER

Lamictal/ODT/XR11 lamotrigine, lamotrigine ER, lamotrigine ODT

Onfi clobazam

Qudexy XR11, Trokendi XR11 topiramate ER

Sabril11 vigabatrin, vigadrone

Topamax11 topiramate

Trileptal11 oxcarbazepine

Zonegran11 zonisamide

SKIN CONDITIONS Apexicon E5, diflorasone, Impoyz5, Olux5, Olux-E5, Psorcon7

betamethasone, clobetasol, halobetasol

Condylox imiquimod 5% cream packet, podofilox 0.5% topical solution

Cordran5 betamethasone, clobetasol, fluocinolone, fluticasone, halobetasol

Elidel pimecrolimus cream

Finacea, MetroCream, MetroGel, MetroLotion, Soolantra12

azelaic acid, topical metronidazole

flurandrenolide, hydrocortisone butyrate lipid cream, lotion5, Pandel5

betamethasone, fluocinolone, fluticasone

Page 27: PRESCRIPTION DRUG LIST CHANGES - Cigna...NUTRITIONAL/DIETARY PreGenna, Trinaz Any generic prenatal vitamin PAIN RELIEF AND INFLAMMATORY DISEASE Amerge generic triptans (e.g. naratriptan;

CIGNA NATIONAL PRESCRIPTION DRUG LIST

Generic medications start with a lowercase letter and brand name medications start with a capital letter.

CIGNA TOTAL SAVINGS FORMULARY (cont)

Start date of change*,**

Drug classMedications that will no longer be covered^^

Generic and/or preferred brand alternatives

January 1, 2021 SKIN CONDITIONS (cont) Tridesilon5 alclometasone, desonide, triamcinolone

Xolegel ciclopirox 0.77% gel, ciclopirox 1% shampoo, ketoconazole 2% cream, ketoconazole 2% foam, selenium 2.5% lotion, sodium sulfacetamide 10% shampoo

SLEEP DISORDERS/SEDATIVES Belsomra8 Dayvigo

TRANSPLANT MEDICATIONS Myfortic mycophenolic acid

Prograf tacrolimus

URINARY TRACT CONDITIONS Procysbi4 CystagonStart date of change*,**

Drug classMedications that will be excluded from coverage

Additional information

January 1, 2021 ALLERGY/NASAL SPRAYS Beconase AQ, Nasonex, Omnaris, Qnasl, Qnasl Children, Xhance, Zetonna,

flunisolide, fluticasone, mometasone

flunisolide, mometasone spray generics products available over-the-counter (e.g. budesonide, fluticasone)

fluticasone 50 mcg spray generics products available over-the-counter (e.g. budesonide)

EYE CONDITIONS azelastine, epinastine products available over-the-counter (e.g. Alaway, Pataday)

Bepreve, Lastacaft, Pazeo, Zerviate azelastine, epinastine eye drops

SKIN CONDITIONS Rosadan Kits azelaic acid, topical metronidazole

Start date of change*,**

Drug class Medications moving to preferred brand

May 7, 2021 CANCER Tabrecta1

April 16, 2021 BLOOD PRESSURE/HEART MEDICATIONS Verquvo

April 2, 2021 CANCER Xtandi

MULTIPLE SCLEROSIS Plegridy1

March 19, 2021 MULTIPLE SCLEROSIS Mayzent 0.25 MG Starter Pack

February 19, 2021 MULTIPLE SCLEROSIS Aubagio1

Start date of change*,**

Drug classMedications becoming non-preferred brand

Generic and/or preferred brand alternatives

April 2, 2021 URINARY TRACT CONDITIONS Gemtesa 75mg tablet darifenacin er, oxybutynin chloride er, tolterodine tartrate er, trospium chloride, Myrbetriq, Toviaz ER

March 19, 2021 BLOOD PRESSURE/HEART MEDICATIONS Orladeyo1 Takhzyro

INFECTIONS Dificid 40mg/ml suspension vancomycin hcl

February 5, 2021 EYE CONDITIONS Eysuvis 0.25% Eye Drops loteprednol etabonate, artificial tears

January 22, 2021 INFECTIONS Alinia 500mg Tablet nitazoxanide

Page 28: PRESCRIPTION DRUG LIST CHANGES - Cigna...NUTRITIONAL/DIETARY PreGenna, Trinaz Any generic prenatal vitamin PAIN RELIEF AND INFLAMMATORY DISEASE Amerge generic triptans (e.g. naratriptan;

Generic medications start with a lowercase letter and brand name medications start with a capital letter.

CIGNA NATIONAL PRESCRIPTION DRUG LIST cont.

Start date of change*,**

Drug classMedications becoming non-preferred brand

Generic and/or preferred brand alternatives

January 16, 2021 HORMONAL AGENTS Mycapssa DR 20 mg capsule1 Somatuline Depot

PARKINSON’S DISEASE Ongentys 50 mg capsule entacapone

Start date of change*,**

Drug class Medications that will need approval (prior authorization)^

May 17, 2021 BLOOD MODIFIERS/BLEEDING DISORDERS Nyvepria1

April 1, 2021 EYE CONDITIONS Eysuvis 0.25% ophthalmic suspension

Lacrisert

HORMONAL AGENTS Synarel1

January 16, 2021 HORMONAL AGENTS Mycapssa DR 20 mg capsule1

PARKINSON’S DISEASE Ongentys 50 mg capsule

January 15, 2021 ASTHMA/COPD/RESPIRATORY Zokinvy1

Start date of change*,**

Drug class Medications that will have a quantity limit

May 17, 2021 CANCER Vitrakvi1

HORMONAL AGENTS Xyosted

NUTRITIONAL/DIETARY Nascobal 500mcg/0.1ml nasal spray device

PAIN RELIEF AND INFLAMMATORY DISEASE Humira 80mg/0.8ml pen1

SKIN CONDITIONS Condylox 0.5% gel

May 17, 2021 SLEEP DISORDERS/SEDATIVES Hetlioz LQ 4mg/ml oral suspension1

May 3, 2021 NUTRITIONAL/DIETARY Calcium 667mg

Phoslyra 667mg/5ml oral solution

Renvela

April 15, 2021 DIABETES Ozempic 4mg/3ml (1.34mg/ml) pre-filled pen

April 1, 2021 ANXIETY/DEPRESSION/BIPOLAR DISORDER Pexeva

PAIN RELIEF AND INFLAMMATORY DISEASE Xeljanz 1 mg/ml oral solution1

SKIN CONDITIONS Gentamicin 0.1% cream, ointment

March 15, 2021 ASTHMA/COPD/RESPIRATORY Trikafta 100/50/75 mg-150 mg tablets1

BLOOD PRESSURE/HEART MEDICATIONS Verquvo

NUTRITIONAL/DIETARY Velphoro 500 mg tablets

SLEEP DISORDERS/SEDATIVES Xyrem1

Xywav1

March 2, 2021 ANTIPARKINSON DRUGS Inbrija 42 mg capsules1

ASTHMA/COPD/RESPIRATORY Trelegy Ellipta 200/62.5/25 mcg

Zokinvy1

HORMONAL AGENTS Divigel 1.25 gram

PARKINSON’S DISEASE Ongentys 25 mg, 50 mg capsules

Page 29: PRESCRIPTION DRUG LIST CHANGES - Cigna...NUTRITIONAL/DIETARY PreGenna, Trinaz Any generic prenatal vitamin PAIN RELIEF AND INFLAMMATORY DISEASE Amerge generic triptans (e.g. naratriptan;

Generic medications start with a lowercase letter and brand name medications start with a capital letter.

CIGNA NATIONAL PRESCRIPTION DRUG LIST cont.

Start date of change*,**

Drug class Medications that will have a quantity limit

March 2, 2021 SEIZURE DISORDERS Fintepla 2.2 mg/ml oral solution1

February 15, 2021 CONTRACEPTION PRODUCTS Phexxi

February 5, 2021 EYE CONDITIONS Eysuvis 0.25% ophthalmic suspension

Start date of change*,**

Drug classMedications being added to Step Therapy Program^,^^

Generic and/or preferred brand alternatives

April 15, 2021 INFECTIONS Vibramycin cap, suspension, and syrup Doxycycline, Minocycline

SKIN CONDITIONS Kerydin generic (Tavaborale) Ciclodan 8% topical solution (branded generic), ciclopirox 8% topical solution, ciclopirox 8% treatment kit

Start date of change*,**

Drug classMedications that will no longer be covered^^

Generic and/or preferred brand alternatives

May 16, 2021 AIDS/HIV Cabenuva suspension atazanavir, lamivudine, Dovato, Edurant, Juluca, Prezista, Tivicay

CANCER Tepmetko1 Tabrecta

CONTRACEPTION PRODUCTS Tyblume altavera, aviane, falmina, lessina, levonor-eth etrad, portia, vienva

PAIN RELIEF AND INFlAMMATORY DISEASE Reditrex methotrexage inj, Rasuvo

SKIN CONDITIONS Tazarotene 0.1% foam tazarotene cream, Tazorac gel

TRANSPLANT MEDICATIONS Lupkynis1 mycophenolate, prednisone

April 16, 2021 CANCER Orgovyx1 Eligard, Firmagon

Riabni 100mg/10ml, 500mg/50ml vial1 Ruxience

GASTROINTESTINAL/HEARTBURN Reltone 200 mg, 400 mg capsule ursodiol

HORMONAL AGENTS Thyquidity euthyrox, levo-t, levothyroxine, levoxyl

SKIN CONDITIONS Impeklo 0.05% Lotion betamethasone dipropionate, clobetasol, desonide, desoximetasone, diflorasone, fluocinonide, halcinonide

Klisyri 1% ointment packet diclofenac 3% gel, fluorouracil 5% cream, solution, imiquimod 5% cream

April 1, 2021 ANXIETY/DEPRESSION/BIPOLAR DISORDER Pexeva, Viibryd citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, sertraline

BLOOD PRESSURE/HEART MEDICATIONS Bystolic atenolol, carvedilol, metoprolol succinate

Edarbi candesartan, irbesartan, losartan, olmesartan, telmisartan, valsartan

Edarbyclor candesartan-HCTZ, irbesartan-HCTZ, losartan-HCTZ, olmesartan-HCTZ, telmisartan-HCTZ, valsartan-HCTZ, chlorthalidone plus valsartan

CONTRACEPTION PRODUCTS Annovera generic oral contraceptives, Xulane patches

Balcoltra Aviane, Larissia, Lessina, levonorgestrel-eth estradiol, Sronyx, Vienva

Lo Loestrin FE Blisolvi FE, Blisolvi 24 FE, Hailey FE, Junel FE, Larin FE, Melodetta 24 FE, norethindrone-eth estradiol FE

Page 30: PRESCRIPTION DRUG LIST CHANGES - Cigna...NUTRITIONAL/DIETARY PreGenna, Trinaz Any generic prenatal vitamin PAIN RELIEF AND INFLAMMATORY DISEASE Amerge generic triptans (e.g. naratriptan;

Generic medications start with a lowercase letter and brand name medications start with a capital letter.

CIGNA NATIONAL PRESCRIPTION DRUG LIST cont.

Start date of change*,**

Drug classMedications that will no longer be covered^^

Generic and/or preferred brand alternatives

April 1, 2021 CONTRACEPTION PRODUCTS Natazia Blisolvi FE, drospirenone-ethinyl estradiol, Estarylla, Junel FE, Sprintec, Tri-Sprintec

Slynd generic progestin-only oral contraceptives

Taytulla Gemmily, norethindrone-eth estradiol FE

DIABETES Afrezza Humalog, Lyumjev

GASTROINTESTINAL/HEARTBURN Clenpiq Gavilyte-G, peg-electrolyte solution, peg-3350, Trilyte with Flavor packets.

Golytely Packets Gavilyte-G, peg-electrolyte solution, peg-3350, Trilyte with Flavor packets.

Plenvu Gavilyte-G, peg-electrolyte solution, peg-3350, Trilyte with Flavor packets.

Suprep Gavilyte-G, peg-electrolyte solution, peg-3350, Trilyte with Flavor packets.

HORMONAL AGENTS Osphena estradiol (cream), Yuvafem, Estring, Premarin (cream)

Premarin Tablets estradiol tablets

Premphase Amabelz, estradiol-norethindrone acetate, Fyavolv, Jinteli, Mimvey, norethindrone-ethinyl estradiol

Prempro Amabelz, estradiol-norethindrone acetate, Fyavolv, Jinteli, Mimvey, norethindrone-ethinyl estradiol

SKIN CONDITIONS Drysol Over the counter alternatives.

March 16, 2021 GASTROINTESTINAL/HEARTBURN Lubiprostone 8 mcg, 24 mcg capsule Linzess, Trulance

PAIN RELIEF AND INFLAMMATORY DISEASE Zolmitriptan 2.5 mg, 5 mg Nasal Spray sumatriptan nasal, Zomig nasal

SKIN CONDITIONS Wynzora 0.005%-0.064% Cream betamethasone dipropionate, calcipotriene-betamethasone dipropionate, clobetasol propionate, diflorasone diacetate, calcipotriene (generic), Enstilar

URINARY TRACT CONDITIONS Vesicare LS 5 MG/5 ML supension oxybutynin, oxybutynin ER

March 12, 2021 PAIN RELIEF AND INFLAMMATORY DISEASE Qdolo 5 MG/ML Solution tramadol (generic tablet)

March 2, 2021 BLOOD PRESSURE/HEART MEDICATIONS Conjupri amlodipine, felodipine, nifedipine, nicardipine

GASTROINTESTINAL/HEARTBURN Sutab 1.479-0.225-0.188 GM tab Gavilyte-G, peg-electrolyte solution, peg-3350, Trilyte with Flavor packets.

SKIN CONDITIONS Winlevi 1% cream clindamycin topical, clindamycin-tretionin, erythromycin topical, tretinoin, Amzeeq, Onexton

February 5, 2021 EYE CONDITIONS Eysuvis 0.25% Eye Drops loteprednol etabonate, artificial tears

Page 31: PRESCRIPTION DRUG LIST CHANGES - Cigna...NUTRITIONAL/DIETARY PreGenna, Trinaz Any generic prenatal vitamin PAIN RELIEF AND INFLAMMATORY DISEASE Amerge generic triptans (e.g. naratriptan;

Medications moving to a higher cost-share tier

New cost-share tier Generic and/or preferred brand alternatives

Descovy T4 emtricitabine/tenofovir disoproxil fumarate 200mg-300mg (generic Truvada)

vancomycin capsule T4 FirvanqMedications that will need approval (prior authorization)

Additional information

capecitabine Your patient can only receive this medication if you request and receive approval from Cigna.

deferasirox

Descovy

Nuedexta

penicillamine

teriparatide 620mcg/2.48ml (generic Forteo)

tobramycin 300mg/5ml inhalation

Vascepa

Drug lists used by patients who purchase their own health plan

CIGNA ESSENTIAL PRESCRIPTION DRUG LIST (for Colorado and Utah)

Medications being added to the Step Therapy program

Generic and/or preferred brand alternatives

Xeljanz XR1 Humira (needs approval)

Xeljanz1

Generic medications start with a lowercase letter and brand name medications start with a capital letter.

Medications that will no longer be covered Generic and/or preferred brand alternatives

Afinitor Tablet everolimus tablet

alogliptin Onglyza

alogliptin/metformin Kombiglyze XR

alogliptin/pioglitazone Kombiglyze XR

Apriso ER mesalamine

Atripla efavirenz/emtricitabine/tenofovir df

Cuprimine penicillamine

Depen penicillamine

Exjade deferasirox

Firazyr icatibant

Forteo teriparatide

Glucagen Gvoke

Glucagon Gvoke

Jadenu Sprinkle & Tablet deferasirox

Letairis ambrisentan

Levocarnitine IV levocarnitine solution or tablet

Lyrica pregabalin

Moxeza moxifloxacin hcl

Prudoxin doxepin 5% cream

Page 32: PRESCRIPTION DRUG LIST CHANGES - Cigna...NUTRITIONAL/DIETARY PreGenna, Trinaz Any generic prenatal vitamin PAIN RELIEF AND INFLAMMATORY DISEASE Amerge generic triptans (e.g. naratriptan;

Generic medications start with a lowercase letter and brand name medications start with a capital letter.

Medications that will no longer be covered Generic and/or preferred brand alternatives

Samsca tolvaptan

Saphris asenapine maleate

Sensipar cinacalcet

Tarceva erlotinib hcl

Tracleer 62.5mg & 125mg bosentan

Truvada 200mg-300mg emtricitabine/tenofovir disoproxil fumarate 200mg-300mg (generic Truvada)

Tykerb lapatinib ditosylate

Zortress everolimus

CIGNA ESSENTIAL PRESCRIPTION DRUG LIST (for Colorado and Utah) cont.

Medications that will be excluded from coverage Additional information

Iodosorb Gel Talk with your patient about switching to a covered alternative.

Lugol's Strong Iodine Solution

Medications moving to a higher cost-share tier

New cost-share tier Generic and/or preferred brand alternatives

vancomycin capsule T4 Firvanq

Descovy T4 emtricitabine/tenofovir disoproxil fumarate 200mg-300mg (generic Truvada)

CIGNA PLUS PRESCRIPTION DRUG LIST (for Illinois, Kansas, Missouri, North Carolina and Tennessee)

Medications that will need approval (prior authorization)

Additional information

capecitabine Your patient can only receive this medication if you request and receive approval from Cigna.deferasirox

Descovy

Ferriprox

Fycompa

Nuedexta

penicillamine

teriparatide 620mcg/2.48ml (generic Forteo)

tobramycin 300mg/5ml inhalation

trientine

Vascepa

Medications being added to the Step Therapy program

Generic and/or preferred brand alternatives

Xeljanz XR1 Humira (needs approval)

Xeljanz1

Page 33: PRESCRIPTION DRUG LIST CHANGES - Cigna...NUTRITIONAL/DIETARY PreGenna, Trinaz Any generic prenatal vitamin PAIN RELIEF AND INFLAMMATORY DISEASE Amerge generic triptans (e.g. naratriptan;

Generic medications start with a lowercase letter and brand name medications start with a capital letter.

CIGNA PLUS PRESCRIPTION DRUG LIST (for Illinois, Kansas, Missouri, North Carolina and Tennessee) cont.

Medications that will no longer be covered Generic and/or preferred brand alternatives

Afinitor Tablet everolimus tablet

alogliptin Onglyza

alogliptin/metformin Kombiglyze XR

alogliptin/pioglitazone Kombiglyze XR

Apriso ER mesalamine

Atripla efavirenz/emtricitabine/tenofovir df

Carnitor SF Oral Solution levocarnitine sf oral solution

Cuprimine penicillamine

Depen penicillamine

Dyrenium triamterene

Exjade deferasirox

Firazyr icatibant

Forteo teriparatide

Glucagen Gvoke

Glucagon Gvoke

Halog 0.1% Cream halcinonide

Jadenu Sprinkle & Tablet deferasirox

Letairis ambrisentan

Levocarnitine IV levocarnitine solution or tablet

Lotemax 0.5% Eye Drops loteprednol etabonate 0.5% eye drops

Lyrica pregabalin

Moxeza moxifloxacin hcl

Naftin 1% Gel naftifine hcl 1% gel

Nascobal cyanocobalamin inj

Noxafil DR 100mg Tablet posaconazole 100mg tablet

Prudoxin doxepin 5% cream

Restasis cyclosporine eye drops

Samsca tolvaptan

Saphris asenapine maleate

Sensipar cinacalcet

Suprax 400mg Capsule cefixime 400mg capsule

Tarceva erlotinib hcl

Tracleer 62.5mg & 125mg bosentan

Truvada 200mg-300mg emtricitabine/tenofovir disoproxil fumarate 200mg-300mg (generic Truvada)

Tykerb lapatinib ditosylate

Uloric febuxostat

Page 34: PRESCRIPTION DRUG LIST CHANGES - Cigna...NUTRITIONAL/DIETARY PreGenna, Trinaz Any generic prenatal vitamin PAIN RELIEF AND INFLAMMATORY DISEASE Amerge generic triptans (e.g. naratriptan;

Generic medications start with a lowercase letter and brand name medications start with a capital letter.

CIGNA PLUS PRESCRIPTION DRUG LIST (for Illinois, Kansas, Missouri, North Carolina and Tennessee) cont.

Medications that will no longer be covered Generic and/or preferred brand alternatives

Velphoro sucroferric oxyhydroxide

Zortress everolimus

Medications that will be excluded from coverage Additional information

Iodosorb Gel Talk with your patient about switching to a covered alternative.

Lugol's Strong Iodine Solution

CIGNA PLUS PRESCRIPTION DRUG LIST (for Florida)

Medications moving to a higher cost-share tier

New cost-share tier Generic and/or preferred brand alternatives

vancomycin capsule T4 Firvanq

Medications that will need approval (prior authorization)

Additional information

capecitabine Your patient can only receive this medication if you request and receive approval from Cigna.deferasirox

Descovy

Ferriprox

Fycompa

Nuedexta Your patient can only receive this medication if you request and receive approval from Cigna.penicillamine

teriparatide 620mcg/2.48ml (generic Forteo)

tobramycin 300mg/5ml inhalation

trientine

Truvada 200mg-300mg

Vascepa

Medications being added to the Step Therapy program

Generic and/or preferred brand alternatives

Xeljanz XR1 Humira (needs approval)

Xeljanz1

Medications that will no longer be covered Generic and/or preferred brand alternatives

Afinitor Tablet everolimus tablet

alogliptin Onglyza

alogliptin/metformin Kombiglyze XR

alogliptin/pioglitazone Kombiglyze XR

Apriso ER mesalamine

Carnitor SF Oral Solution levocarnitine sf oral solution

Page 35: PRESCRIPTION DRUG LIST CHANGES - Cigna...NUTRITIONAL/DIETARY PreGenna, Trinaz Any generic prenatal vitamin PAIN RELIEF AND INFLAMMATORY DISEASE Amerge generic triptans (e.g. naratriptan;

Generic medications start with a lowercase letter and brand name medications start with a capital letter.

CIGNA PLUS PRESCRIPTION DRUG LIST (for Florida) cont.

Medications that will no longer be covered Generic and/or preferred brand alternatives

Cuprimine penicillamine

Depen penicillamine

Dyrenium triamterene

Exjade deferasirox

Firazyr icatibant

Forteo teriparatide

Glucagen Gvoke

Glucagon Gvoke

Halog 0.1% Cream halcinonide

Jadenu Sprinkle & Tablet deferasirox

Letairis ambrisentan

Levocarnitine IV levocarnitine solution or tablet

Lotemax 0.5% Eye Drops loteprednol etabonate 0.5% eye drops

Lyrica pregabalin

Moxeza moxifloxacin hcl

Naftin 1% Gel naftifine hcl 1% gel

Nascobal cyanocobalamin inj

Noxafil DR 100mg Tablet posaconazole 100mg tablet

Prudoxin doxepin 5% cream

Restasis cyclosporine eye drops

Samsca tolvaptan

Saphris asenapine maleate

Sensipar cinacalcet

Suprax 400mg Capsule cefixime 400mg capsule

Tarceva erlotinib hcl

Tracleer 62.5mg & 125mg bosentan

Tykerb lapatinib ditosylate

Uloric febuxostat

Velphoro sucroferric oxyhydroxide

Zortress everolimus

Medications that will be excluded from coverage Additional information

Iodosorb Gel Talk with your patient about switching to a covered alternative.

Lugol's Strong Iodine Solution

Page 36: PRESCRIPTION DRUG LIST CHANGES - Cigna...NUTRITIONAL/DIETARY PreGenna, Trinaz Any generic prenatal vitamin PAIN RELIEF AND INFLAMMATORY DISEASE Amerge generic triptans (e.g. naratriptan;

Generic medications start with a lowercase letter and brand name medications start with a capital letter.

CIGNA PREMIERE PRESCRIPTION DRUG LIST (for Arizona and Virginia)

Medications moving to a higher cost-share tier

New cost-share tier Generic and/or preferred brand alternatives

Descovy T4 emtricitabine/tenofovir disoproxil fumarate 200mg-300mg (generic Truvada)

vancomycin capsule T4 Firvanq

Medications that will need approval (prior authorization)

Additional information

capecitabine Your patient can only receive this medication if you request and receive approval from Cigna.deferasirox

Descovy

Ferriprox

Fycompa

Nuedexta

penicillamine

teriparatide 620mcg/2.48ml (generic Forteo)

tobramycin 300mg/5ml inhalation

trientine

Vascepa

Medications being added to the Step Therapy program

Generic and/or preferred brand alternatives

Xeljanz XR1 Humira (needs approval)

Xeljanz1

Medications that will no longer be covered Generic and/or preferred brand alternatives

Afinitor Tablet everolimus tablet

alogliptin Onglyza

alogliptin/metformin Kombiglyze XR

alogliptin/pioglitazone Kombiglyze XR

Apriso ER mesalamine

Atripla efavirenz/emtricitabine/tenofovir df

Carnitor SF Oral Solution levocarnitine sf oral solution

Cuprimine penicillamine

Depen penicillamine

Dyrenium triamterene

Exjade deferasirox

Firazyr icatibant

Forteo teriparatide

Glucagen Gvoke

Glucagon Gvoke

Halog 0.1% Cream halcinonide

Jadenu Sprinkle & Tablet deferasirox

Page 37: PRESCRIPTION DRUG LIST CHANGES - Cigna...NUTRITIONAL/DIETARY PreGenna, Trinaz Any generic prenatal vitamin PAIN RELIEF AND INFLAMMATORY DISEASE Amerge generic triptans (e.g. naratriptan;

Generic medications start with a lowercase letter and brand name medications start with a capital letter.

CIGNA PREMIERE PRESCRIPTION DRUG LIST (for Arizona and Virginia) cont.

Medications that will no longer be covered Generic and/or preferred brand alternatives

Letairis ambrisentan

Levocarnitine IV levocarnitine solution or tablet

Lotemax 0.5% Eye Drops loteprednol etabonate 0.5% eye drops

Lyrica pregabalin

Moxeza moxifloxacin hcl

Naftin 1% Gel naftifine hcl 1% gel

Nascobal cyanocobalamin inj

Noxafil DR 100mg Tablet posaconazole 100mg tablet

Prudoxin doxepin 5% cream

Restasis cyclosporine eye drops

Samsca tolvaptan

Saphris asenapine maleate

Sensipar cinacalcet

Suprax 400mg Capsule cefixime 400mg capsule

Tarceva erlotinib hcl

Tracleer 62.5mg & 125mg bosentan

Truvada 200mg-300mg emtricitabine/tenofovir disoproxil fumarate 200mg-300mg (generic Truvada)

Tykerb lapatinib ditosylate

Uloric febuxostat

Velphoro sucroferric oxyhydroxide

Zortress everolimus

Medications that will be excluded from coverage Additional information

Iodosorb Gel Talk with your patient about switching to a covered alternative.

Lugol's Strong Iodine Solution

Page 38: PRESCRIPTION DRUG LIST CHANGES - Cigna...NUTRITIONAL/DIETARY PreGenna, Trinaz Any generic prenatal vitamin PAIN RELIEF AND INFLAMMATORY DISEASE Amerge generic triptans (e.g. naratriptan;

* State laws in Texas and Louisiana may require your plan to cover these medications at the current benefit level until your plan renews. This means that if the medication is taken off the drug list, is moved to a higher cost-share tier or needs approval from Cigna before your plan will cover it, these changes may not begin until your plan’s renewal date. Customers can call the number on their Cigna ID card to find out if these state laws apply to your plan.

** State law in Illinois may require your plan to cover these medications at your current benefit level until your plan renews. This means that if customers currently have prior authorization for your plan to cover the medication, the drug list change(s) listed here may not affect them until your plan renewal date. If customers do not currently have prior authorization, they may continue to receive coverage at the current benefit level if their doctor requests it. Customers can call the number on their Cigna ID card to find out if this state law applies to your plan.

1. This is a specialty drug. For plans that cover specialty drugs on a specialty tier, this change won’t affect its cost.

2. If your plan has Member Pay Difference (MPD), the MPD penalty will apply to this drug as of 1/1/21. However, if your plan allows for Dispense as Written (DAW) and the doctor requests the brand, the penalty won’t apply.

3. These changes may not apply to your specific plan. Not all plans include requirements for prior authorization, quantity limits and/or Step Therapy.

4. For new prescriptions only. This change won’t affect customers currently taking this drug.

5. Current authorizations will expire 1/1/21. There is a “medical necessity” review process in place for customers who want to continue using this drug.

6. There is a “medical necessity” review process in place for customers who have proven they have exhausted drug alternatives and want to use a drug moving to not-covered status.

7. If Cigna approves continued coverage of this drug, the customer will pay a higher cost-share to fill the prescription.

8. This drug will no longer part of Step Therapy as of 1/1/21. Current authorizations will expire 1/1/21. There is a “medical necessity” review process in place for customers who want to continue using this drug. However, if Cigna approves continued coverage, the customer will pay a higher cost-share to fill the prescription.

9. This drug will no longer part of Step Therapy as of 1/1/21. Current authorizations will expire 1/1/21. There is a “medical necessity” review process in place for customers who want to continue using this drug.

10. Current authorizations will expire 1/1/21. There is a “medical necessity” review process in place for customers who want to continue using this drug. However, if Cigna approves continued coverage, the customer will pay a higher cost-share to fill the prescription.

11. This change doesn’t affect customers currently taking this drug to treat a seizure condition. Current authorizations will expire 1/1/21. There is a “medical necessity” review process in place for customers who want to continue using this drug.

12. If Cigna approves continued coverage of this drug, the customer will pay a higher cost-share to fill the prescription. This drug may also be subject to a MPD penalty.

13. This change won’t affect customers currently taking this drug until their current authorization expires.

14. This drug also requires prior authorization as of 1/1/21.

15. This drug will be part of Step Therapy as of 1/1/21. Current authorizations will expire 1/1/21. There is a “medical necessity” review process in place for customers who want to continue using this drug.

16. There is a “medical necessity” review process in place for customers who have proven they have exhausted drug alternatives and want to use a Step Therapy drug.

Cigna reserves the right to make changes to the Drug List without notice. Your plan may cover additional medications; please refer to your enrollment materials for details. Cigna does not take responsibility for any medication decisions made by the doctor or pharmacist. Cigna may receive payments from manufacturers of certain preferred brand medications, and in limited instances, certain non-preferred brand medications, that may or may not be shared with your plan depending on its arrangement with Cigna. Depending upon plan design, market conditions, the extent to which manufacturer payments are shared with your plan and other factors as of the date of service, the preferred brand medication may or may not represent the lowest-cost brand medication within its class for you and/or your plan. Health benefit plans vary, but in general to be eligible for coverage a drug must be approved by the Food and Drug Administration (FDA), prescribed by a health care professional, purchased from a licensed pharmacy and medically necessary. If your plan provides coverage for certain prescription drugs with no cost-share, you may be required to use an in-network pharmacy to fill the prescription. If you use a pharmacy that does not participate in your plan’s network, your prescription may not be covered, or reimbursement may be limited by your plan’s copayment, coinsurance or deductible requirements. Certain features described in this document may not be applicable to your specific health plan, and plan features may vary by location and plan type. Refer to your plan documents for costs and complete details of your plan’s prescription drug coverage.

All Cigna products and services are provided exclusively by or through operating subsidiaries of Cigna Corporation, including Cigna Health and Life Insurance Company, Connecticut General Life Insurance Company, and HMO or service company subsidiaries of Cigna Health Corporation. The Cigna name, logo, and other Cigna marks are owned by Cigna Intellectual Property, Inc.

951714 © 2021 Cigna. Some content provided under license. CRP2012_007122.1 UPDATED_05/21/2021