Results

Materials and methods

Acknowledgments

ZARATE-MORALES, A., GASPAR-CARCAMO, R.E., LOPEZ-RODRIGUEZ, V., FLORES-MORENO, A., TREJO-BALLADO, F., AVILA-RODRIGUEZ, M.A.

Unidad PET, Facultad de Medicina, Universidad Nacional Autónoma de México, 04510 , D.F. México.

Introduction

Conclusions

This work was supported by CONACYT Grant 121652, UNAM-DGAPA-PAPIIT TA200512 and International Atomic Energy Agency RC16467.

RDS 111 in 2008(8 targets, 40 A)

Acceptance test of the system was performed by irradiating the gold disk for 2h at 40µA without apparent signal of damage. The solid target system have been tested successfully producing Ga and Cu radioisotopes by irradiating electrodeposited targets of Zn and Ni, respectively. Nevertheless the success, some problems: Poor cooling-water system Difficulty for irradiation of foils Although not common, target jamming after bombardment

Eclipse HP in 2011

(4 targets, 60A)

A dual beam line (BL) RDS 111 cyclotron for radionuclide production wasinstalled at the National Autonomous University of Mexico in 2001. One ofthe BL´s was upgraded to Eclipse HP in 2008 and the second BL wasrecently upgraded (2011) with the option for the irradiation of solidtargets for the production of metallic radioisotopes.

Automatic and manual operation of the solid target system ispossible from the cyclotron control software and thegraphical user interface (GUI) shows the status of all involvedparameters.

natZn or natNi targets were preparedby electrodeposition of ZnCl2 orNi(NO3)2 on gold disk.

Zn Target (x10)

5.5 V, 30 min(70 – 50 mA)

Ni Target (x10)

3.4 V, 9 h(30 – 20 mA)

In vivo serial microPET images demonstrated rapidC6 tumor uptake of 66Ga-DOTA-E-[c(RGDfK)2]

A solid target system was fitted onto an existing self-shielded 11 MeV cyclotron. In our experience the system is capable to produceuseful quantities of metallic PET radionuclides for preclinical applications, mainly limited by the manual removal of the target thatincreases radiation exposure to personnel.

11 MeV Protons

Cooling water(7 °C)

natZn or natNi targets were left on the tungstencontainer over 17 and 1 h respectively, so thatshort- lived products could decay.

natZn targets were bombarded(10 to 40 µA) 1 h

natNi targets were bombarded (5 µA) 30 min

Micro-derenzo phantom and mice withsubcutaneously growing C6 xenografts microPETimages were acquired using a microPET scanner (Focus 120 Concorde Microsystem).

(Focus 120)

66Ga (56% +, Emax = 4.2 MeV)

The radiochemical separation wasachieved using cation-exchangechromatography

At the beginning the mostcommon problem with the Zn-targets was due to poor qualityelectrodeposition but now it isunder control.

1 h biodistribution 3 h biodistribution 20 h biodistribution 24h biodistribution