The fabrication and characterization of poly (dimethyl-co-methylmethacrylate) siloxane/ poly (ethylene glycol) diacrylate for tissue engineering application

The fabrication and characterization of poly (dimethyl-co-methylmethacrylate) siloxane/ poly (ethylene glycol) diacrylate for tissue engineering (TE) application Name: Lim Kar WaiLecture: Dr. Zuratul Ain Abdul Binti HamidDate: 9 October 2015Tissue engineering applicationEvolution of scaffold materials in engineered tissueCriteria for scaffolding materials in tissue engineering applicationsMaterials studied

hydrophobic inorganic polymers(matrix)

biocompatibilityexcellent gas permeabilityhighly flexible when lightly crosslinkedhydrophilic organic polymers(crosslinker)

biocompatibilityexcellent water permeability

Flow chart of the research studyResearch objective:To fabricate a 3-dimensional porous structure hydrogel with excellent mass transport properties

Step 1: Synthesis of poly (dimethyl-co-methylhydrido) siloxane precursor solution (PDDMHS)Chemical formulation for synthesis of PDMMHSChemicalConcentration (mmole)Mass (g)Boiling point ( C)Volume (L)D467.4320.0175-176-D4H11.242.7--HMDS3.750.6--Trifflic acid-16220Let mass of D4= 20gConcentration= 20/296.62= 0.0674 mole

Hence, mole of D4H needed=0.0674 3/18= 0.01124 mole mass od D4H needed= 2.70g

Hence, mole of HMDS needed= 0.0674 1/18= 0.00375 mole mass of HMDS needed= 0.00375 162.38= 0.60 g

Step 2: Synthesis of poly (dimethyl-co-methylmethacrylate) siloxane precursor solution(PDMMMS)

Step 3: Hydrogel fabricationUV-crosslinking using UV chamber equipped with Philip uv-A tube that emit energy in the wavelength region of 300-400 nm.

Photoinitiator used: Irgacure 651 Parameter studied: Different weight ratio of PDMMMS and PEGDA Characterization: Chemical FTIR, gel content, swelling ratio, thermal properties, mechanical properties and morphologyThank You