presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

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Dr/ ABD ALLAH NAZEER. MD. Ultrasound of the adrenal glands and the kidneys.

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Page 1: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Dr ABD ALLAH NAZEER MD

Ultrasound of the adrenal glands and the kidneys

Diagram of the adrenal glands showing

their relations to neighboring organs

Cross-sectional diagram at the level of the adrenal glands The adrenal glands are the Y-shaped structures lying anteromedial to the kidneys Pa = pancreas rK = right kidney lK = left kidney A = aorta V = inferior vena cava SC = spinal column

Anatomy The adrenal glands are small caplike glandular organs situated in close

proximity to the kidneys Often these ldquosuprarenalrdquo glands are incorrectly

looked for above the kidneys but the term ldquoadrenalrdquo correctly implies that each

gland is predominantly medial to the upper pole of the associated kidney The

right adrenal gland has a linear or V shape while the left adrenal gland is more

V- or Y-shaped

The wings of each gland are 2 ndash 5 cm long and 6 ndash 10 mm thick Their

physiological function is hormone production The adrenal cortex secretes

cortisol aldosterone and sex hormones while the adrenal medulla secretes

epinephrine and norepinephrine

The normal adrenal glands are difficult to visualize with ultrasound This

requires good scanning conditions a high-resolution transducer and a

meticulous examination by a knowledgeable sonographer It is more accurate

then to speak of evaluating the ldquoadrenal regionrdquo rather than the glands

themselves CT can consistently define the normal-sized adrenal glands giving

this study a priority role in the primary imaging of these structures

The EUS of the upper gastrointestinal tract shows the adrenal gland in the best picture quality but this is possible only on the left side the right adrenal gland in EUS is detectable only in 30-40 of examinations The attending vessels (left Aa and Vv suprarenales) are visible only with the endosonographical technique In primary diagnostics the indicated EUS is not favored

EchogenicityWhen the normal adrenal glands are seen using

ultrasound they have a long and hyperechoic

narrow shape typically with 5 layers of stratification with a hypoechoic cortex and medulla

The adrenal glands can almost always be visualized in newborns The physiological hypertrophy at this stage of life results in relatively large glands that can easily be identified using ultrasound and show clear corticomedullary differentiation Normal adrenal gland On the right side the normal adrenal gland regularly is visible using optimized examination techniques (approximately 1 x 4 cm) The left adrenal gland is in generally only visible in about 40-50 of all cases

Sonoanatomy of the left adrenal gland - image by high resolution endosonography The proximal and the caudal limbs are visible in high resolution quality and the adrenal gland-marrow is more echorich

Adrenal gland hyperplasia Hyperplastic adrenal glands are usually hypoechoic especially

in the cortical zone They appear plump and elongated may

show low-level nodular echoes and the borderline between

cortex and marrow disappears

The adrenal gland here are larger than 10 mm usually are only

moderately enlarged (to 2 cm)

Adrenal hyperplasia can occur for example as an adaptive

response in ACTH-dependent Cushing syndrome

It may have a paraneoplastic cause or it may occur in

hyperaldosteronism The hyperplasia is even bilateral in most

cases For the advanced examiner the adrenal glands are poorly

demarcated from their surroundings

Again CT provides a better view of the hyperplastic adrenal

glands which usually cannot be detected with ultrasound Also

the EUS on the left side shows the hyperplastic adrenal gland

better than transcutaneous ultrasound Differentiation to

adenoma normally is only possible by histology or cytology (so

FNB)

EUS shows on left side an enlarged proximal shank

of adrenal gland which occurs in nodular hyperplasia

Adrenal Cyst A cyst of the adrenal region is anechoic has smooth margins and shows distal acoustic enhancement Its extent is variable True cysts have regular walls and are filled with serous material

Round sharply circumscribed echo-free mass located dorsal

to the right liver and cranial to the right kidney adrenal cyst

Intra-adrenal Hemorrhage (Hematoma) Bleeding into an adrenal gland is anechoic in its early

stage It can occur in newborns due to obstetric trauma

hypoxia or coagulation disorders Intra-adrenal

hemorrhage may correlate clinically with adrenal

insufficiency

A large central hemorrhage (adrenal apoplexy)

consistently leads to the marked enlargement of the gland

An older hemorrhage becomes increasingly echogenic

over time and may eventually be completely absorbed

Differentiation is required from partially cystic neuroblastomas in small children

Up to 25 of patients who sustain blunt abdominal trauma are discovered to have hematomas in the adrenal region They also occur in patients on anticoagulant medication and can lead to hypocortisolism (Addison disease)

Cystic anechoic mass in the left adrenal gland representing a hemorrhage

Echo -free intra-adrenal hemorrhage in a

newborn with high resolution ultrasound

Adrenal Abscess An abscess of the adrenal glands is rarely anechoic It is usually hypoechoic

or has a complex echo structure When the contents are anechoic the clinical

and laboratory findings can differentiate the lesion from an ordinary cyst The

wall is irregular and distal acoustic enhancement may be present

Transverse ultrasound image reveals anechoic cystic masses containing internal echoes and debris at bilateral supra renal area and right is measuring more than left

Longitudinal ultrasound image reveals anechoic cystic abscess With wall calcification and needle in the lesion during procedure

Benign adrenal gland tumours Adenoma Adenomas are uniformly hypoechoic with smooth margins and a round to oval shape although some lesions have scalloped borders (polycyclic) Adenomas occasionally have an inhomogeneous appearance Autopsy statistics indicate that they are quite common (10ndash20) but most adenomas (90) produce no endocrine symptoms they are bdquosilentldquo and too small to be seen with ultrasound The average size of adenomas in one study was 15 cm although they may exceed 5 cm in diameter In a small percentage of patients adenomas are bilateral Functioning and nonfunctioning adenomas are indistinguishable by their sonographic features

Medial to the upper pole of the right kidney is a sharply circumscribed hypoechoic mass typical adrenal adenoma

Hypoechoic sharply circumscribed adenoma of the right adrenal gland discovered

at routine ultrasound (confirmed by ultrasound-guided fine-needle aspiration)

Approximately 5 cm hypoechoic inhomogenous mass above the right kidney adenoma (incidentaloma) without associated symptoms detected at routine upper abdominal ultrasound Histology identified as an adrenal adenoma (most common incidentaloma)

Lipoma Myelolipoma

Lipoma A pure lipoma of the adrenal glands has

smooth margins and high homogeneous

echogenicity In contrast to the mixed tissues of

myolipoma posterior acoustic shadowing does

not occur Lipoma is rare and shows no proliferative tendency

Myelolipoma Adrenal myelolipoma has smooth margins and a homogeneous hyperechoic structure It resembles a renal angiomyolipoma in its sonographic features Posterior acoustic shadowing is often present Malignant transformation is not known to occur The tumour consists histologically of fat and bone marrow tissue (hematopoietic cells and reticular cells) Intratumoral hemorrhage and calcifications may be seen

Homogeneous sharply circumscribed hyperechoic tumour adjacent to the right kidney Classic adrenal myelolipoma

In CEUS a myelolipoma shows a nearly constant

contrast enhancement without wash out

Calcification Complete or partial calcification of the adrenal glands is characterized by a

typical echo complex with a posterior acoustic shadow Calcifications can

result from a retained intra-adrenal hemorrhage or a prior inflammatory

process (eg tuberculosis) Patients occasionally show the clinical

manifestations of Addison disease However calcifications can also develop in

tumours (carcinoma metastases Pheochromocytoma adenoma)

In the proximal left kidney in the adrenal gland region wefound a classical calcification with dorsal acoustic shadow

Small calcifications also occur in tumours of adrenal gland most often observed in pheochromocytoma

Malignant adrenal gland tumours Metastases With their rich blood supply the adrenal glands are the fourth

most frequent site for hematogenous metastasis Metastases

to the adrenal glands account for the majority of solid adrenal

tumours after the adenomas

In contrast to adenomas these lesions are less homogeneous

and often have irregular margins The most common

primaries are bronchial carcinoma (25ndash30 ) breast

carcinoma and malignant melanoma Other possible sources

are gastrointestinal urological and gynecological tumours

(renal carcinoma gastric carcinoma pancreatic carcinoma

and others) Adrenal metastases are bilateral in up to 30 of

cases and this can produce the clinical manifestations of

Addison disease Bronchial carcinoma is virtually the only

tumour that is associated with isolated adrenal metastases

(in ca 15-20 )

Large metastasis from bronchial carcinoma on the right

side with a very inhomogeneous internal structure Solid

components are seen along with central liquid areas

Transverse scan shows a metastasis with a complex echo structure ldquowedgedrdquo between right lobe of the liver inferior vena cava the kidney and spinal column

Transverse scan of a metastasis of the right adrenal gland with complex structure beside a primary tumour of lung cancer

Partial metastases esp of lung cancer show

a wash out of contrast media in late phase

US examination longitudinal view Above the right kidney in the adrenal region a solid slightly inhomogeneous mass can be seen Neuroblastoma MRI examination

axial T2 weighted image Irregular large solid inhomogeneous retroperitoneal tumor

Pheochromocytoma Pheochromocytoma is a tumour of the adrenal medulla that is generally

detected sonographically (80ndash90 of cases) following the appearance

of clinical symptoms (hypertension and tachycardia caused by

increased catecholamine secretion)

Most pheochromocytomas are already several centimeters in diameter

when diagnosed They have smooth margins a round shape and a

nonhomogeneous or complex echo structure

Hypoechoic liquid components are also observed A spectrum of

appearances may be seen Pheochromocytomas are bilateral in

approximately 10 of cases and extra-adrenal in 10ndash20

The ldquoZuckerkandl organrdquo should be looked for at the level of the origin

of the inferior mesenteric artery anterior to the aorta

Other extra-adrenal sites are the renal hilum bladder wall and thorax

Pheochromocytoma is occasionally seen posterior to the renal vein in

transverse scans Rarely pheochromocytoma is diagnosed in the

setting of multiple endocrine neoplasia (MEN) From 2 to 5 of

pheochromocytomas are malignant Owing to the risk of inciting a

hypertensive crisis fine-needle aspiration biopsy causes discrepant

discussions about FNB

Nonhomogeneous tumour with a hyperechoic center (positive endocrine test increased catecholamine secretion) ndash Pheochromocytoma

Large functionally active pheochromocytoma (7 cm in diameter) The scan shows that most of tumour is hypoechoic with some hyperechoic regions

Lymphoma The adrenal region is a rare extranodal site of occurrence for lymphoma

Foci of lymphomatous infiltration have smooth borders and are

hypoechoic Differentiation is required from lymphomas in the renal or

splenic hilum If invasion by lymphoma is suspected other nodal

stations should be scanned and commonly infiltrated organs (spleen

liver) should be closely scrutinized

Perisplenic lymphoma in the left adrenal region of a patient with B-cell lymphoma

Colour Doppler shows hypervascularisation of the lymphatic tissue

Adrenal Carcinoma Adrenal carcinoma is usually inhomogeneous hypoechoic or echo complex with irregular margins It frequently infiltrates its surroundings and metastases can be demonstrated in the adrenal region and in other organs (eg the liver) The adrenal carcinoma is a very rare (1 17 million inhabitants) highly malignant tumour with a poor prognosis Adrenal carcinoma is indistinguishable sonographically from a metastasis although the visualization of additional tumours can advance the differential diagnosis Most adrenal carcinomas are hormone-producing Sometimes one can get evidence from detection of other tumour sign The tumour is usually detected only after it has reached considerable size (often gt8 cm) Intratumoral hemorrhage necrotic foci and calcifications may occur adding to the variegated appearance

Adrenal carcinoma may be hypoechoic or may have a complex echo structure Usually it

was relatively large when diagnosed (in this case 8 cm times 9 cm) and had irregular margins

Right adrenal adenocarcinoma A Sonogram showing a complex mass with cystic changes in the right adrenal gland (arrows) B Computed tomogram showing the mass (arrows)

Incidentaloma An incidentaloma is an adrenal tumour that is detected incidentally in an asymptomatic patient Incidentalomas are found in 1 of CT examinations They are much less common in ultrasound examinations because of the difficulty in defining small lesions (lt 2 cm) The predominantly hypoechoic tumours account for the great majority of incidentalomas shows the algorithm used in the investigation of incidentalomas Approximately 10 to 15 of these tumours are hormonally active In some cases ultrasound-guided fine-needle aspiration can also aid in the evaluation of incidentalomas but only ca 1 to 2 of these tumours are malignant

Abdominal ultrasound examination incidentally found most hypoechoic lesions

smaller 2 cm without clinical symptoms ndash which is typical for incidentalomas

Histoplasmosis is a geographically restricted form of

fungal infection Adrenal involvement is seen in disseminated disease but sometimes it may be the only site of demonstrable disease Early diagnosis and treatment may save the patient from catastrophic adrenal insufficiency We present two patients showing bilateral adrenomegaly on ultrasonography and contrast-enhanced CT and was diagnosed to have histoplasmosis on fine-needle aspiration cytology

Histoplasmosis is an infective condition caused by a

dimorphic saprophytic fungus Histoplasma capsulatum and is acquired by inhalation of its spores Soil rich in bird and bat dropping is its natural habitat and it exists as a mycelium in the atmosphere

Both adrenal gland were enlarged and hypoechoic at US study

US show bilateral hypoechoic lesions and CT showed peripherally enhancing hypodense bilateral adrenals with peripheral rim and septate enhancement

ULTRASOUND OF THE ADULT KIDNEY ndash Normal

Coronal scan plane for the Right Kidney Longitudinal Normal Kidney

Scan plane transverse kidney Transverse normal image

Common anatomical variantsAtrophic small kidneyHorseshoe kidneyEctopic kidneyDuplex kidneyCross fused ectopiaUnilateral renal agenesis

COMMON PATHOLOGYCalculusRenal cyst Cortical and Para-pelvicAngiomyolipmaRenal infectionRenal cell carcinomaTransitional cell carcinomaMedullary sponge kidneyPolycystic kidney disease

Horseshoe kidney A transverse and longitudinal view across the midline showing the isthmus across the aorta

Cross fused ectopic kidney The left kidney is fused to the lower pole of the right kidney

A baggy extra-renal pelvis

Pelvic ectopic kidney

UltrasonographyOn sonograms stones are demonstrated as bright echogenic foci with posterior acoustic shadowing Stones are visualized fairly well with US in the kidneys and the distal ureter at or near the UVJ especially if dilatation is present US is good for the visualization of complications such as hydronephrosis (or other signs of obstruction) however some patients with acute obstruction have little or no dilationIn particular US is helpful in evaluating those with renal insufficiency or contraindications for the use of contrast media however US is often skipped in favor of nonenhanced CTIn addition US is good for characterizing lucent filling defects that are visualized as stones on IVU However US does not provide direct physiologic information regarding the degree of obstruction Doppler imaging may demonstrate a high resistive index in acute obstruction but this may not occur immediately or after forniceal rupture Absence of the ureteral jet as visualized with color Doppler on the symptomatic side is presumptive evidence for a high-grade obstruction in a well-hydrated patient

Degree of confidenceUS is very insensitive for stones especially stones smaller than 2 mm stones at the UPJ or stones in the mid ureter Fowler et al suggest that US has a sensitivity as low as 24 compared with nonenhanced CT Furthermore estimations of stone size may not be accurate Compared with nonenhanced CT US is more dependent on the operators ability and more time consuming

False positivesnegativesUS is fairly specific when stones are seen with a specificity as high as 90 With US matrix or indinavir stones may have soft tissue echogenicity without shadowing False-positive findings may result from renal vascular calcifications False-positive diagnoses of hydronephrosis also result from dilated vascular structures in the renal hilum Doppler imaging is helpful in distinguishing dilated vascular structures from hydronephrosis

Renal sonogram demonstrates an echogenic shadowing calculus in the renal collecting system with hydronephrosis

US images for renal stones

US images of staghorn stones

US images for ureteric stones

US images for nephrocalcinosis

Renal cystA renal cyst is a fluid collection in the kidney There are several types based on the Bosniak classification The majority are benign simple cysts that can be monitored and not intervened upon However some are cancerous or are suspicious for cancer and are commonly removed in a surgical procedure called nephrectomyNumerous renal cysts are seen in the cystic kidney diseases which include polycystic kidney diseaseand medullary sponge kidney

The Bosniak classification categorizes renal cysts into five groupsCategory I

Benign simple cyst with thin wall without septa calcifications or solid

components

It does not enhance with contrast and has a density equal to that of water

Category IIBenign cyst with a few thin septa which may contain fine calcifications or a

small

segment of mildly thickened calcification This includes homogenous

high-attenuation lesions less than 3 cm with sharp margins(Rich Kosak) but

without enhancement

Category IIFWell marginated cysts with a number of thin septa with or without mild

enhancement or thickening of septa Calcifications may be present these

may be thick and nodular There are no enhancing soft tissue components

This also includes nonenhancing high-attenuation lesions that are completely

contained within the kidney and are 3 cm or larger

Category IIIIndeterminate cystic masses with thickened irregular septa with enhancement

Category IVMalignant cystic masses with all the characteristics of category III lesions

but also with enhancing soft tissue components independent of but adjacent

to the septa

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 11)

Classic findings of a simple cyst(Bosniak category 111)

Classic findings of a simple cyst(Bosniak category 1V)

Para-pelvic cyst USamp CT images

US of polycystic kidney disease

Renal infection

US of acute pyelonephritis

Acute bacterial pyelonephritis (a) US scan shows a wedge-shaped hyperechoic focus (arrowhead) in the upper pole of the right kidney related to acute bacterial pyelonephritis (b) Color flow US image demonstrates diminished flow through the involved area

US and color Doppler images of right kidney shows focal hyperechoic nephritis with decreased perfusion at the Doppler US

US and color Doppler images of kidney shows two multifocal nephritis with decreased perfusion at the Doppler US

Masslike appearance of acute bacterial pyelonephritis US and CT images

Emphysematous pyelonephritis (a) US image shows nondependent echoes within the left kidney that demonstrate a ring-down artifact (b) Corresponding CT scan helps confirm that this pattern is caused by intraparenchymal air

Xanthogranulomatous pyelonephritis (a) Contrast-enhanced CT scan demonstrates bilateral staghorn calculi with distention of the right collecting system secondary to inflammatory debris (b) US scan also shows the dilated

collecting system (arrowheads) and a shadowing calculus (arrow)

Early and mature abscess cavities (a) US scan demonstrates a geographic hypoechoic focus from an abscess in the upper pole of the right kidney (b) On a US scan of a more mature abscess the cavity is better defined with a visible pseudocapsule and through transmission that is evidenced by increased echogenicity deep to the upper pole lesion

Pyohydronephrosis

Pyohydronephrosis

Renal hydatidosis is an insidious disease and patients

often present with nonspecific clinical signs or symptoms Presenting complaints are dull flank pain hematuria palpable flank mass hypertension and renal colic

Disseminated abdominal retroperitoneal and pelvic hydatid disease (a) The right kidney is pushed to the midline and the left kidney is hydronephrotic and shrunken by retroperitoneal hydatid cysts (b) Ultrasound of the abdomen showing cystic lesions in the retroperitoneum in the position of the kidneys

Hydatid disease of the kidney US and CT images

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 2: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Diagram of the adrenal glands showing

their relations to neighboring organs

Cross-sectional diagram at the level of the adrenal glands The adrenal glands are the Y-shaped structures lying anteromedial to the kidneys Pa = pancreas rK = right kidney lK = left kidney A = aorta V = inferior vena cava SC = spinal column

Anatomy The adrenal glands are small caplike glandular organs situated in close

proximity to the kidneys Often these ldquosuprarenalrdquo glands are incorrectly

looked for above the kidneys but the term ldquoadrenalrdquo correctly implies that each

gland is predominantly medial to the upper pole of the associated kidney The

right adrenal gland has a linear or V shape while the left adrenal gland is more

V- or Y-shaped

The wings of each gland are 2 ndash 5 cm long and 6 ndash 10 mm thick Their

physiological function is hormone production The adrenal cortex secretes

cortisol aldosterone and sex hormones while the adrenal medulla secretes

epinephrine and norepinephrine

The normal adrenal glands are difficult to visualize with ultrasound This

requires good scanning conditions a high-resolution transducer and a

meticulous examination by a knowledgeable sonographer It is more accurate

then to speak of evaluating the ldquoadrenal regionrdquo rather than the glands

themselves CT can consistently define the normal-sized adrenal glands giving

this study a priority role in the primary imaging of these structures

The EUS of the upper gastrointestinal tract shows the adrenal gland in the best picture quality but this is possible only on the left side the right adrenal gland in EUS is detectable only in 30-40 of examinations The attending vessels (left Aa and Vv suprarenales) are visible only with the endosonographical technique In primary diagnostics the indicated EUS is not favored

EchogenicityWhen the normal adrenal glands are seen using

ultrasound they have a long and hyperechoic

narrow shape typically with 5 layers of stratification with a hypoechoic cortex and medulla

The adrenal glands can almost always be visualized in newborns The physiological hypertrophy at this stage of life results in relatively large glands that can easily be identified using ultrasound and show clear corticomedullary differentiation Normal adrenal gland On the right side the normal adrenal gland regularly is visible using optimized examination techniques (approximately 1 x 4 cm) The left adrenal gland is in generally only visible in about 40-50 of all cases

Sonoanatomy of the left adrenal gland - image by high resolution endosonography The proximal and the caudal limbs are visible in high resolution quality and the adrenal gland-marrow is more echorich

Adrenal gland hyperplasia Hyperplastic adrenal glands are usually hypoechoic especially

in the cortical zone They appear plump and elongated may

show low-level nodular echoes and the borderline between

cortex and marrow disappears

The adrenal gland here are larger than 10 mm usually are only

moderately enlarged (to 2 cm)

Adrenal hyperplasia can occur for example as an adaptive

response in ACTH-dependent Cushing syndrome

It may have a paraneoplastic cause or it may occur in

hyperaldosteronism The hyperplasia is even bilateral in most

cases For the advanced examiner the adrenal glands are poorly

demarcated from their surroundings

Again CT provides a better view of the hyperplastic adrenal

glands which usually cannot be detected with ultrasound Also

the EUS on the left side shows the hyperplastic adrenal gland

better than transcutaneous ultrasound Differentiation to

adenoma normally is only possible by histology or cytology (so

FNB)

EUS shows on left side an enlarged proximal shank

of adrenal gland which occurs in nodular hyperplasia

Adrenal Cyst A cyst of the adrenal region is anechoic has smooth margins and shows distal acoustic enhancement Its extent is variable True cysts have regular walls and are filled with serous material

Round sharply circumscribed echo-free mass located dorsal

to the right liver and cranial to the right kidney adrenal cyst

Intra-adrenal Hemorrhage (Hematoma) Bleeding into an adrenal gland is anechoic in its early

stage It can occur in newborns due to obstetric trauma

hypoxia or coagulation disorders Intra-adrenal

hemorrhage may correlate clinically with adrenal

insufficiency

A large central hemorrhage (adrenal apoplexy)

consistently leads to the marked enlargement of the gland

An older hemorrhage becomes increasingly echogenic

over time and may eventually be completely absorbed

Differentiation is required from partially cystic neuroblastomas in small children

Up to 25 of patients who sustain blunt abdominal trauma are discovered to have hematomas in the adrenal region They also occur in patients on anticoagulant medication and can lead to hypocortisolism (Addison disease)

Cystic anechoic mass in the left adrenal gland representing a hemorrhage

Echo -free intra-adrenal hemorrhage in a

newborn with high resolution ultrasound

Adrenal Abscess An abscess of the adrenal glands is rarely anechoic It is usually hypoechoic

or has a complex echo structure When the contents are anechoic the clinical

and laboratory findings can differentiate the lesion from an ordinary cyst The

wall is irregular and distal acoustic enhancement may be present

Transverse ultrasound image reveals anechoic cystic masses containing internal echoes and debris at bilateral supra renal area and right is measuring more than left

Longitudinal ultrasound image reveals anechoic cystic abscess With wall calcification and needle in the lesion during procedure

Benign adrenal gland tumours Adenoma Adenomas are uniformly hypoechoic with smooth margins and a round to oval shape although some lesions have scalloped borders (polycyclic) Adenomas occasionally have an inhomogeneous appearance Autopsy statistics indicate that they are quite common (10ndash20) but most adenomas (90) produce no endocrine symptoms they are bdquosilentldquo and too small to be seen with ultrasound The average size of adenomas in one study was 15 cm although they may exceed 5 cm in diameter In a small percentage of patients adenomas are bilateral Functioning and nonfunctioning adenomas are indistinguishable by their sonographic features

Medial to the upper pole of the right kidney is a sharply circumscribed hypoechoic mass typical adrenal adenoma

Hypoechoic sharply circumscribed adenoma of the right adrenal gland discovered

at routine ultrasound (confirmed by ultrasound-guided fine-needle aspiration)

Approximately 5 cm hypoechoic inhomogenous mass above the right kidney adenoma (incidentaloma) without associated symptoms detected at routine upper abdominal ultrasound Histology identified as an adrenal adenoma (most common incidentaloma)

Lipoma Myelolipoma

Lipoma A pure lipoma of the adrenal glands has

smooth margins and high homogeneous

echogenicity In contrast to the mixed tissues of

myolipoma posterior acoustic shadowing does

not occur Lipoma is rare and shows no proliferative tendency

Myelolipoma Adrenal myelolipoma has smooth margins and a homogeneous hyperechoic structure It resembles a renal angiomyolipoma in its sonographic features Posterior acoustic shadowing is often present Malignant transformation is not known to occur The tumour consists histologically of fat and bone marrow tissue (hematopoietic cells and reticular cells) Intratumoral hemorrhage and calcifications may be seen

Homogeneous sharply circumscribed hyperechoic tumour adjacent to the right kidney Classic adrenal myelolipoma

In CEUS a myelolipoma shows a nearly constant

contrast enhancement without wash out

Calcification Complete or partial calcification of the adrenal glands is characterized by a

typical echo complex with a posterior acoustic shadow Calcifications can

result from a retained intra-adrenal hemorrhage or a prior inflammatory

process (eg tuberculosis) Patients occasionally show the clinical

manifestations of Addison disease However calcifications can also develop in

tumours (carcinoma metastases Pheochromocytoma adenoma)

In the proximal left kidney in the adrenal gland region wefound a classical calcification with dorsal acoustic shadow

Small calcifications also occur in tumours of adrenal gland most often observed in pheochromocytoma

Malignant adrenal gland tumours Metastases With their rich blood supply the adrenal glands are the fourth

most frequent site for hematogenous metastasis Metastases

to the adrenal glands account for the majority of solid adrenal

tumours after the adenomas

In contrast to adenomas these lesions are less homogeneous

and often have irregular margins The most common

primaries are bronchial carcinoma (25ndash30 ) breast

carcinoma and malignant melanoma Other possible sources

are gastrointestinal urological and gynecological tumours

(renal carcinoma gastric carcinoma pancreatic carcinoma

and others) Adrenal metastases are bilateral in up to 30 of

cases and this can produce the clinical manifestations of

Addison disease Bronchial carcinoma is virtually the only

tumour that is associated with isolated adrenal metastases

(in ca 15-20 )

Large metastasis from bronchial carcinoma on the right

side with a very inhomogeneous internal structure Solid

components are seen along with central liquid areas

Transverse scan shows a metastasis with a complex echo structure ldquowedgedrdquo between right lobe of the liver inferior vena cava the kidney and spinal column

Transverse scan of a metastasis of the right adrenal gland with complex structure beside a primary tumour of lung cancer

Partial metastases esp of lung cancer show

a wash out of contrast media in late phase

US examination longitudinal view Above the right kidney in the adrenal region a solid slightly inhomogeneous mass can be seen Neuroblastoma MRI examination

axial T2 weighted image Irregular large solid inhomogeneous retroperitoneal tumor

Pheochromocytoma Pheochromocytoma is a tumour of the adrenal medulla that is generally

detected sonographically (80ndash90 of cases) following the appearance

of clinical symptoms (hypertension and tachycardia caused by

increased catecholamine secretion)

Most pheochromocytomas are already several centimeters in diameter

when diagnosed They have smooth margins a round shape and a

nonhomogeneous or complex echo structure

Hypoechoic liquid components are also observed A spectrum of

appearances may be seen Pheochromocytomas are bilateral in

approximately 10 of cases and extra-adrenal in 10ndash20

The ldquoZuckerkandl organrdquo should be looked for at the level of the origin

of the inferior mesenteric artery anterior to the aorta

Other extra-adrenal sites are the renal hilum bladder wall and thorax

Pheochromocytoma is occasionally seen posterior to the renal vein in

transverse scans Rarely pheochromocytoma is diagnosed in the

setting of multiple endocrine neoplasia (MEN) From 2 to 5 of

pheochromocytomas are malignant Owing to the risk of inciting a

hypertensive crisis fine-needle aspiration biopsy causes discrepant

discussions about FNB

Nonhomogeneous tumour with a hyperechoic center (positive endocrine test increased catecholamine secretion) ndash Pheochromocytoma

Large functionally active pheochromocytoma (7 cm in diameter) The scan shows that most of tumour is hypoechoic with some hyperechoic regions

Lymphoma The adrenal region is a rare extranodal site of occurrence for lymphoma

Foci of lymphomatous infiltration have smooth borders and are

hypoechoic Differentiation is required from lymphomas in the renal or

splenic hilum If invasion by lymphoma is suspected other nodal

stations should be scanned and commonly infiltrated organs (spleen

liver) should be closely scrutinized

Perisplenic lymphoma in the left adrenal region of a patient with B-cell lymphoma

Colour Doppler shows hypervascularisation of the lymphatic tissue

Adrenal Carcinoma Adrenal carcinoma is usually inhomogeneous hypoechoic or echo complex with irregular margins It frequently infiltrates its surroundings and metastases can be demonstrated in the adrenal region and in other organs (eg the liver) The adrenal carcinoma is a very rare (1 17 million inhabitants) highly malignant tumour with a poor prognosis Adrenal carcinoma is indistinguishable sonographically from a metastasis although the visualization of additional tumours can advance the differential diagnosis Most adrenal carcinomas are hormone-producing Sometimes one can get evidence from detection of other tumour sign The tumour is usually detected only after it has reached considerable size (often gt8 cm) Intratumoral hemorrhage necrotic foci and calcifications may occur adding to the variegated appearance

Adrenal carcinoma may be hypoechoic or may have a complex echo structure Usually it

was relatively large when diagnosed (in this case 8 cm times 9 cm) and had irregular margins

Right adrenal adenocarcinoma A Sonogram showing a complex mass with cystic changes in the right adrenal gland (arrows) B Computed tomogram showing the mass (arrows)

Incidentaloma An incidentaloma is an adrenal tumour that is detected incidentally in an asymptomatic patient Incidentalomas are found in 1 of CT examinations They are much less common in ultrasound examinations because of the difficulty in defining small lesions (lt 2 cm) The predominantly hypoechoic tumours account for the great majority of incidentalomas shows the algorithm used in the investigation of incidentalomas Approximately 10 to 15 of these tumours are hormonally active In some cases ultrasound-guided fine-needle aspiration can also aid in the evaluation of incidentalomas but only ca 1 to 2 of these tumours are malignant

Abdominal ultrasound examination incidentally found most hypoechoic lesions

smaller 2 cm without clinical symptoms ndash which is typical for incidentalomas

Histoplasmosis is a geographically restricted form of

fungal infection Adrenal involvement is seen in disseminated disease but sometimes it may be the only site of demonstrable disease Early diagnosis and treatment may save the patient from catastrophic adrenal insufficiency We present two patients showing bilateral adrenomegaly on ultrasonography and contrast-enhanced CT and was diagnosed to have histoplasmosis on fine-needle aspiration cytology

Histoplasmosis is an infective condition caused by a

dimorphic saprophytic fungus Histoplasma capsulatum and is acquired by inhalation of its spores Soil rich in bird and bat dropping is its natural habitat and it exists as a mycelium in the atmosphere

Both adrenal gland were enlarged and hypoechoic at US study

US show bilateral hypoechoic lesions and CT showed peripherally enhancing hypodense bilateral adrenals with peripheral rim and septate enhancement

ULTRASOUND OF THE ADULT KIDNEY ndash Normal

Coronal scan plane for the Right Kidney Longitudinal Normal Kidney

Scan plane transverse kidney Transverse normal image

Common anatomical variantsAtrophic small kidneyHorseshoe kidneyEctopic kidneyDuplex kidneyCross fused ectopiaUnilateral renal agenesis

COMMON PATHOLOGYCalculusRenal cyst Cortical and Para-pelvicAngiomyolipmaRenal infectionRenal cell carcinomaTransitional cell carcinomaMedullary sponge kidneyPolycystic kidney disease

Horseshoe kidney A transverse and longitudinal view across the midline showing the isthmus across the aorta

Cross fused ectopic kidney The left kidney is fused to the lower pole of the right kidney

A baggy extra-renal pelvis

Pelvic ectopic kidney

UltrasonographyOn sonograms stones are demonstrated as bright echogenic foci with posterior acoustic shadowing Stones are visualized fairly well with US in the kidneys and the distal ureter at or near the UVJ especially if dilatation is present US is good for the visualization of complications such as hydronephrosis (or other signs of obstruction) however some patients with acute obstruction have little or no dilationIn particular US is helpful in evaluating those with renal insufficiency or contraindications for the use of contrast media however US is often skipped in favor of nonenhanced CTIn addition US is good for characterizing lucent filling defects that are visualized as stones on IVU However US does not provide direct physiologic information regarding the degree of obstruction Doppler imaging may demonstrate a high resistive index in acute obstruction but this may not occur immediately or after forniceal rupture Absence of the ureteral jet as visualized with color Doppler on the symptomatic side is presumptive evidence for a high-grade obstruction in a well-hydrated patient

Degree of confidenceUS is very insensitive for stones especially stones smaller than 2 mm stones at the UPJ or stones in the mid ureter Fowler et al suggest that US has a sensitivity as low as 24 compared with nonenhanced CT Furthermore estimations of stone size may not be accurate Compared with nonenhanced CT US is more dependent on the operators ability and more time consuming

False positivesnegativesUS is fairly specific when stones are seen with a specificity as high as 90 With US matrix or indinavir stones may have soft tissue echogenicity without shadowing False-positive findings may result from renal vascular calcifications False-positive diagnoses of hydronephrosis also result from dilated vascular structures in the renal hilum Doppler imaging is helpful in distinguishing dilated vascular structures from hydronephrosis

Renal sonogram demonstrates an echogenic shadowing calculus in the renal collecting system with hydronephrosis

US images for renal stones

US images of staghorn stones

US images for ureteric stones

US images for nephrocalcinosis

Renal cystA renal cyst is a fluid collection in the kidney There are several types based on the Bosniak classification The majority are benign simple cysts that can be monitored and not intervened upon However some are cancerous or are suspicious for cancer and are commonly removed in a surgical procedure called nephrectomyNumerous renal cysts are seen in the cystic kidney diseases which include polycystic kidney diseaseand medullary sponge kidney

The Bosniak classification categorizes renal cysts into five groupsCategory I

Benign simple cyst with thin wall without septa calcifications or solid

components

It does not enhance with contrast and has a density equal to that of water

Category IIBenign cyst with a few thin septa which may contain fine calcifications or a

small

segment of mildly thickened calcification This includes homogenous

high-attenuation lesions less than 3 cm with sharp margins(Rich Kosak) but

without enhancement

Category IIFWell marginated cysts with a number of thin septa with or without mild

enhancement or thickening of septa Calcifications may be present these

may be thick and nodular There are no enhancing soft tissue components

This also includes nonenhancing high-attenuation lesions that are completely

contained within the kidney and are 3 cm or larger

Category IIIIndeterminate cystic masses with thickened irregular septa with enhancement

Category IVMalignant cystic masses with all the characteristics of category III lesions

but also with enhancing soft tissue components independent of but adjacent

to the septa

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 11)

Classic findings of a simple cyst(Bosniak category 111)

Classic findings of a simple cyst(Bosniak category 1V)

Para-pelvic cyst USamp CT images

US of polycystic kidney disease

Renal infection

US of acute pyelonephritis

Acute bacterial pyelonephritis (a) US scan shows a wedge-shaped hyperechoic focus (arrowhead) in the upper pole of the right kidney related to acute bacterial pyelonephritis (b) Color flow US image demonstrates diminished flow through the involved area

US and color Doppler images of right kidney shows focal hyperechoic nephritis with decreased perfusion at the Doppler US

US and color Doppler images of kidney shows two multifocal nephritis with decreased perfusion at the Doppler US

Masslike appearance of acute bacterial pyelonephritis US and CT images

Emphysematous pyelonephritis (a) US image shows nondependent echoes within the left kidney that demonstrate a ring-down artifact (b) Corresponding CT scan helps confirm that this pattern is caused by intraparenchymal air

Xanthogranulomatous pyelonephritis (a) Contrast-enhanced CT scan demonstrates bilateral staghorn calculi with distention of the right collecting system secondary to inflammatory debris (b) US scan also shows the dilated

collecting system (arrowheads) and a shadowing calculus (arrow)

Early and mature abscess cavities (a) US scan demonstrates a geographic hypoechoic focus from an abscess in the upper pole of the right kidney (b) On a US scan of a more mature abscess the cavity is better defined with a visible pseudocapsule and through transmission that is evidenced by increased echogenicity deep to the upper pole lesion

Pyohydronephrosis

Pyohydronephrosis

Renal hydatidosis is an insidious disease and patients

often present with nonspecific clinical signs or symptoms Presenting complaints are dull flank pain hematuria palpable flank mass hypertension and renal colic

Disseminated abdominal retroperitoneal and pelvic hydatid disease (a) The right kidney is pushed to the midline and the left kidney is hydronephrotic and shrunken by retroperitoneal hydatid cysts (b) Ultrasound of the abdomen showing cystic lesions in the retroperitoneum in the position of the kidneys

Hydatid disease of the kidney US and CT images

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 3: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Anatomy The adrenal glands are small caplike glandular organs situated in close

proximity to the kidneys Often these ldquosuprarenalrdquo glands are incorrectly

looked for above the kidneys but the term ldquoadrenalrdquo correctly implies that each

gland is predominantly medial to the upper pole of the associated kidney The

right adrenal gland has a linear or V shape while the left adrenal gland is more

V- or Y-shaped

The wings of each gland are 2 ndash 5 cm long and 6 ndash 10 mm thick Their

physiological function is hormone production The adrenal cortex secretes

cortisol aldosterone and sex hormones while the adrenal medulla secretes

epinephrine and norepinephrine

The normal adrenal glands are difficult to visualize with ultrasound This

requires good scanning conditions a high-resolution transducer and a

meticulous examination by a knowledgeable sonographer It is more accurate

then to speak of evaluating the ldquoadrenal regionrdquo rather than the glands

themselves CT can consistently define the normal-sized adrenal glands giving

this study a priority role in the primary imaging of these structures

The EUS of the upper gastrointestinal tract shows the adrenal gland in the best picture quality but this is possible only on the left side the right adrenal gland in EUS is detectable only in 30-40 of examinations The attending vessels (left Aa and Vv suprarenales) are visible only with the endosonographical technique In primary diagnostics the indicated EUS is not favored

EchogenicityWhen the normal adrenal glands are seen using

ultrasound they have a long and hyperechoic

narrow shape typically with 5 layers of stratification with a hypoechoic cortex and medulla

The adrenal glands can almost always be visualized in newborns The physiological hypertrophy at this stage of life results in relatively large glands that can easily be identified using ultrasound and show clear corticomedullary differentiation Normal adrenal gland On the right side the normal adrenal gland regularly is visible using optimized examination techniques (approximately 1 x 4 cm) The left adrenal gland is in generally only visible in about 40-50 of all cases

Sonoanatomy of the left adrenal gland - image by high resolution endosonography The proximal and the caudal limbs are visible in high resolution quality and the adrenal gland-marrow is more echorich

Adrenal gland hyperplasia Hyperplastic adrenal glands are usually hypoechoic especially

in the cortical zone They appear plump and elongated may

show low-level nodular echoes and the borderline between

cortex and marrow disappears

The adrenal gland here are larger than 10 mm usually are only

moderately enlarged (to 2 cm)

Adrenal hyperplasia can occur for example as an adaptive

response in ACTH-dependent Cushing syndrome

It may have a paraneoplastic cause or it may occur in

hyperaldosteronism The hyperplasia is even bilateral in most

cases For the advanced examiner the adrenal glands are poorly

demarcated from their surroundings

Again CT provides a better view of the hyperplastic adrenal

glands which usually cannot be detected with ultrasound Also

the EUS on the left side shows the hyperplastic adrenal gland

better than transcutaneous ultrasound Differentiation to

adenoma normally is only possible by histology or cytology (so

FNB)

EUS shows on left side an enlarged proximal shank

of adrenal gland which occurs in nodular hyperplasia

Adrenal Cyst A cyst of the adrenal region is anechoic has smooth margins and shows distal acoustic enhancement Its extent is variable True cysts have regular walls and are filled with serous material

Round sharply circumscribed echo-free mass located dorsal

to the right liver and cranial to the right kidney adrenal cyst

Intra-adrenal Hemorrhage (Hematoma) Bleeding into an adrenal gland is anechoic in its early

stage It can occur in newborns due to obstetric trauma

hypoxia or coagulation disorders Intra-adrenal

hemorrhage may correlate clinically with adrenal

insufficiency

A large central hemorrhage (adrenal apoplexy)

consistently leads to the marked enlargement of the gland

An older hemorrhage becomes increasingly echogenic

over time and may eventually be completely absorbed

Differentiation is required from partially cystic neuroblastomas in small children

Up to 25 of patients who sustain blunt abdominal trauma are discovered to have hematomas in the adrenal region They also occur in patients on anticoagulant medication and can lead to hypocortisolism (Addison disease)

Cystic anechoic mass in the left adrenal gland representing a hemorrhage

Echo -free intra-adrenal hemorrhage in a

newborn with high resolution ultrasound

Adrenal Abscess An abscess of the adrenal glands is rarely anechoic It is usually hypoechoic

or has a complex echo structure When the contents are anechoic the clinical

and laboratory findings can differentiate the lesion from an ordinary cyst The

wall is irregular and distal acoustic enhancement may be present

Transverse ultrasound image reveals anechoic cystic masses containing internal echoes and debris at bilateral supra renal area and right is measuring more than left

Longitudinal ultrasound image reveals anechoic cystic abscess With wall calcification and needle in the lesion during procedure

Benign adrenal gland tumours Adenoma Adenomas are uniformly hypoechoic with smooth margins and a round to oval shape although some lesions have scalloped borders (polycyclic) Adenomas occasionally have an inhomogeneous appearance Autopsy statistics indicate that they are quite common (10ndash20) but most adenomas (90) produce no endocrine symptoms they are bdquosilentldquo and too small to be seen with ultrasound The average size of adenomas in one study was 15 cm although they may exceed 5 cm in diameter In a small percentage of patients adenomas are bilateral Functioning and nonfunctioning adenomas are indistinguishable by their sonographic features

Medial to the upper pole of the right kidney is a sharply circumscribed hypoechoic mass typical adrenal adenoma

Hypoechoic sharply circumscribed adenoma of the right adrenal gland discovered

at routine ultrasound (confirmed by ultrasound-guided fine-needle aspiration)

Approximately 5 cm hypoechoic inhomogenous mass above the right kidney adenoma (incidentaloma) without associated symptoms detected at routine upper abdominal ultrasound Histology identified as an adrenal adenoma (most common incidentaloma)

Lipoma Myelolipoma

Lipoma A pure lipoma of the adrenal glands has

smooth margins and high homogeneous

echogenicity In contrast to the mixed tissues of

myolipoma posterior acoustic shadowing does

not occur Lipoma is rare and shows no proliferative tendency

Myelolipoma Adrenal myelolipoma has smooth margins and a homogeneous hyperechoic structure It resembles a renal angiomyolipoma in its sonographic features Posterior acoustic shadowing is often present Malignant transformation is not known to occur The tumour consists histologically of fat and bone marrow tissue (hematopoietic cells and reticular cells) Intratumoral hemorrhage and calcifications may be seen

Homogeneous sharply circumscribed hyperechoic tumour adjacent to the right kidney Classic adrenal myelolipoma

In CEUS a myelolipoma shows a nearly constant

contrast enhancement without wash out

Calcification Complete or partial calcification of the adrenal glands is characterized by a

typical echo complex with a posterior acoustic shadow Calcifications can

result from a retained intra-adrenal hemorrhage or a prior inflammatory

process (eg tuberculosis) Patients occasionally show the clinical

manifestations of Addison disease However calcifications can also develop in

tumours (carcinoma metastases Pheochromocytoma adenoma)

In the proximal left kidney in the adrenal gland region wefound a classical calcification with dorsal acoustic shadow

Small calcifications also occur in tumours of adrenal gland most often observed in pheochromocytoma

Malignant adrenal gland tumours Metastases With their rich blood supply the adrenal glands are the fourth

most frequent site for hematogenous metastasis Metastases

to the adrenal glands account for the majority of solid adrenal

tumours after the adenomas

In contrast to adenomas these lesions are less homogeneous

and often have irregular margins The most common

primaries are bronchial carcinoma (25ndash30 ) breast

carcinoma and malignant melanoma Other possible sources

are gastrointestinal urological and gynecological tumours

(renal carcinoma gastric carcinoma pancreatic carcinoma

and others) Adrenal metastases are bilateral in up to 30 of

cases and this can produce the clinical manifestations of

Addison disease Bronchial carcinoma is virtually the only

tumour that is associated with isolated adrenal metastases

(in ca 15-20 )

Large metastasis from bronchial carcinoma on the right

side with a very inhomogeneous internal structure Solid

components are seen along with central liquid areas

Transverse scan shows a metastasis with a complex echo structure ldquowedgedrdquo between right lobe of the liver inferior vena cava the kidney and spinal column

Transverse scan of a metastasis of the right adrenal gland with complex structure beside a primary tumour of lung cancer

Partial metastases esp of lung cancer show

a wash out of contrast media in late phase

US examination longitudinal view Above the right kidney in the adrenal region a solid slightly inhomogeneous mass can be seen Neuroblastoma MRI examination

axial T2 weighted image Irregular large solid inhomogeneous retroperitoneal tumor

Pheochromocytoma Pheochromocytoma is a tumour of the adrenal medulla that is generally

detected sonographically (80ndash90 of cases) following the appearance

of clinical symptoms (hypertension and tachycardia caused by

increased catecholamine secretion)

Most pheochromocytomas are already several centimeters in diameter

when diagnosed They have smooth margins a round shape and a

nonhomogeneous or complex echo structure

Hypoechoic liquid components are also observed A spectrum of

appearances may be seen Pheochromocytomas are bilateral in

approximately 10 of cases and extra-adrenal in 10ndash20

The ldquoZuckerkandl organrdquo should be looked for at the level of the origin

of the inferior mesenteric artery anterior to the aorta

Other extra-adrenal sites are the renal hilum bladder wall and thorax

Pheochromocytoma is occasionally seen posterior to the renal vein in

transverse scans Rarely pheochromocytoma is diagnosed in the

setting of multiple endocrine neoplasia (MEN) From 2 to 5 of

pheochromocytomas are malignant Owing to the risk of inciting a

hypertensive crisis fine-needle aspiration biopsy causes discrepant

discussions about FNB

Nonhomogeneous tumour with a hyperechoic center (positive endocrine test increased catecholamine secretion) ndash Pheochromocytoma

Large functionally active pheochromocytoma (7 cm in diameter) The scan shows that most of tumour is hypoechoic with some hyperechoic regions

Lymphoma The adrenal region is a rare extranodal site of occurrence for lymphoma

Foci of lymphomatous infiltration have smooth borders and are

hypoechoic Differentiation is required from lymphomas in the renal or

splenic hilum If invasion by lymphoma is suspected other nodal

stations should be scanned and commonly infiltrated organs (spleen

liver) should be closely scrutinized

Perisplenic lymphoma in the left adrenal region of a patient with B-cell lymphoma

Colour Doppler shows hypervascularisation of the lymphatic tissue

Adrenal Carcinoma Adrenal carcinoma is usually inhomogeneous hypoechoic or echo complex with irregular margins It frequently infiltrates its surroundings and metastases can be demonstrated in the adrenal region and in other organs (eg the liver) The adrenal carcinoma is a very rare (1 17 million inhabitants) highly malignant tumour with a poor prognosis Adrenal carcinoma is indistinguishable sonographically from a metastasis although the visualization of additional tumours can advance the differential diagnosis Most adrenal carcinomas are hormone-producing Sometimes one can get evidence from detection of other tumour sign The tumour is usually detected only after it has reached considerable size (often gt8 cm) Intratumoral hemorrhage necrotic foci and calcifications may occur adding to the variegated appearance

Adrenal carcinoma may be hypoechoic or may have a complex echo structure Usually it

was relatively large when diagnosed (in this case 8 cm times 9 cm) and had irregular margins

Right adrenal adenocarcinoma A Sonogram showing a complex mass with cystic changes in the right adrenal gland (arrows) B Computed tomogram showing the mass (arrows)

Incidentaloma An incidentaloma is an adrenal tumour that is detected incidentally in an asymptomatic patient Incidentalomas are found in 1 of CT examinations They are much less common in ultrasound examinations because of the difficulty in defining small lesions (lt 2 cm) The predominantly hypoechoic tumours account for the great majority of incidentalomas shows the algorithm used in the investigation of incidentalomas Approximately 10 to 15 of these tumours are hormonally active In some cases ultrasound-guided fine-needle aspiration can also aid in the evaluation of incidentalomas but only ca 1 to 2 of these tumours are malignant

Abdominal ultrasound examination incidentally found most hypoechoic lesions

smaller 2 cm without clinical symptoms ndash which is typical for incidentalomas

Histoplasmosis is a geographically restricted form of

fungal infection Adrenal involvement is seen in disseminated disease but sometimes it may be the only site of demonstrable disease Early diagnosis and treatment may save the patient from catastrophic adrenal insufficiency We present two patients showing bilateral adrenomegaly on ultrasonography and contrast-enhanced CT and was diagnosed to have histoplasmosis on fine-needle aspiration cytology

Histoplasmosis is an infective condition caused by a

dimorphic saprophytic fungus Histoplasma capsulatum and is acquired by inhalation of its spores Soil rich in bird and bat dropping is its natural habitat and it exists as a mycelium in the atmosphere

Both adrenal gland were enlarged and hypoechoic at US study

US show bilateral hypoechoic lesions and CT showed peripherally enhancing hypodense bilateral adrenals with peripheral rim and septate enhancement

ULTRASOUND OF THE ADULT KIDNEY ndash Normal

Coronal scan plane for the Right Kidney Longitudinal Normal Kidney

Scan plane transverse kidney Transverse normal image

Common anatomical variantsAtrophic small kidneyHorseshoe kidneyEctopic kidneyDuplex kidneyCross fused ectopiaUnilateral renal agenesis

COMMON PATHOLOGYCalculusRenal cyst Cortical and Para-pelvicAngiomyolipmaRenal infectionRenal cell carcinomaTransitional cell carcinomaMedullary sponge kidneyPolycystic kidney disease

Horseshoe kidney A transverse and longitudinal view across the midline showing the isthmus across the aorta

Cross fused ectopic kidney The left kidney is fused to the lower pole of the right kidney

A baggy extra-renal pelvis

Pelvic ectopic kidney

UltrasonographyOn sonograms stones are demonstrated as bright echogenic foci with posterior acoustic shadowing Stones are visualized fairly well with US in the kidneys and the distal ureter at or near the UVJ especially if dilatation is present US is good for the visualization of complications such as hydronephrosis (or other signs of obstruction) however some patients with acute obstruction have little or no dilationIn particular US is helpful in evaluating those with renal insufficiency or contraindications for the use of contrast media however US is often skipped in favor of nonenhanced CTIn addition US is good for characterizing lucent filling defects that are visualized as stones on IVU However US does not provide direct physiologic information regarding the degree of obstruction Doppler imaging may demonstrate a high resistive index in acute obstruction but this may not occur immediately or after forniceal rupture Absence of the ureteral jet as visualized with color Doppler on the symptomatic side is presumptive evidence for a high-grade obstruction in a well-hydrated patient

Degree of confidenceUS is very insensitive for stones especially stones smaller than 2 mm stones at the UPJ or stones in the mid ureter Fowler et al suggest that US has a sensitivity as low as 24 compared with nonenhanced CT Furthermore estimations of stone size may not be accurate Compared with nonenhanced CT US is more dependent on the operators ability and more time consuming

False positivesnegativesUS is fairly specific when stones are seen with a specificity as high as 90 With US matrix or indinavir stones may have soft tissue echogenicity without shadowing False-positive findings may result from renal vascular calcifications False-positive diagnoses of hydronephrosis also result from dilated vascular structures in the renal hilum Doppler imaging is helpful in distinguishing dilated vascular structures from hydronephrosis

Renal sonogram demonstrates an echogenic shadowing calculus in the renal collecting system with hydronephrosis

US images for renal stones

US images of staghorn stones

US images for ureteric stones

US images for nephrocalcinosis

Renal cystA renal cyst is a fluid collection in the kidney There are several types based on the Bosniak classification The majority are benign simple cysts that can be monitored and not intervened upon However some are cancerous or are suspicious for cancer and are commonly removed in a surgical procedure called nephrectomyNumerous renal cysts are seen in the cystic kidney diseases which include polycystic kidney diseaseand medullary sponge kidney

The Bosniak classification categorizes renal cysts into five groupsCategory I

Benign simple cyst with thin wall without septa calcifications or solid

components

It does not enhance with contrast and has a density equal to that of water

Category IIBenign cyst with a few thin septa which may contain fine calcifications or a

small

segment of mildly thickened calcification This includes homogenous

high-attenuation lesions less than 3 cm with sharp margins(Rich Kosak) but

without enhancement

Category IIFWell marginated cysts with a number of thin septa with or without mild

enhancement or thickening of septa Calcifications may be present these

may be thick and nodular There are no enhancing soft tissue components

This also includes nonenhancing high-attenuation lesions that are completely

contained within the kidney and are 3 cm or larger

Category IIIIndeterminate cystic masses with thickened irregular septa with enhancement

Category IVMalignant cystic masses with all the characteristics of category III lesions

but also with enhancing soft tissue components independent of but adjacent

to the septa

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 11)

Classic findings of a simple cyst(Bosniak category 111)

Classic findings of a simple cyst(Bosniak category 1V)

Para-pelvic cyst USamp CT images

US of polycystic kidney disease

Renal infection

US of acute pyelonephritis

Acute bacterial pyelonephritis (a) US scan shows a wedge-shaped hyperechoic focus (arrowhead) in the upper pole of the right kidney related to acute bacterial pyelonephritis (b) Color flow US image demonstrates diminished flow through the involved area

US and color Doppler images of right kidney shows focal hyperechoic nephritis with decreased perfusion at the Doppler US

US and color Doppler images of kidney shows two multifocal nephritis with decreased perfusion at the Doppler US

Masslike appearance of acute bacterial pyelonephritis US and CT images

Emphysematous pyelonephritis (a) US image shows nondependent echoes within the left kidney that demonstrate a ring-down artifact (b) Corresponding CT scan helps confirm that this pattern is caused by intraparenchymal air

Xanthogranulomatous pyelonephritis (a) Contrast-enhanced CT scan demonstrates bilateral staghorn calculi with distention of the right collecting system secondary to inflammatory debris (b) US scan also shows the dilated

collecting system (arrowheads) and a shadowing calculus (arrow)

Early and mature abscess cavities (a) US scan demonstrates a geographic hypoechoic focus from an abscess in the upper pole of the right kidney (b) On a US scan of a more mature abscess the cavity is better defined with a visible pseudocapsule and through transmission that is evidenced by increased echogenicity deep to the upper pole lesion

Pyohydronephrosis

Pyohydronephrosis

Renal hydatidosis is an insidious disease and patients

often present with nonspecific clinical signs or symptoms Presenting complaints are dull flank pain hematuria palpable flank mass hypertension and renal colic

Disseminated abdominal retroperitoneal and pelvic hydatid disease (a) The right kidney is pushed to the midline and the left kidney is hydronephrotic and shrunken by retroperitoneal hydatid cysts (b) Ultrasound of the abdomen showing cystic lesions in the retroperitoneum in the position of the kidneys

Hydatid disease of the kidney US and CT images

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 4: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

EchogenicityWhen the normal adrenal glands are seen using

ultrasound they have a long and hyperechoic

narrow shape typically with 5 layers of stratification with a hypoechoic cortex and medulla

The adrenal glands can almost always be visualized in newborns The physiological hypertrophy at this stage of life results in relatively large glands that can easily be identified using ultrasound and show clear corticomedullary differentiation Normal adrenal gland On the right side the normal adrenal gland regularly is visible using optimized examination techniques (approximately 1 x 4 cm) The left adrenal gland is in generally only visible in about 40-50 of all cases

Sonoanatomy of the left adrenal gland - image by high resolution endosonography The proximal and the caudal limbs are visible in high resolution quality and the adrenal gland-marrow is more echorich

Adrenal gland hyperplasia Hyperplastic adrenal glands are usually hypoechoic especially

in the cortical zone They appear plump and elongated may

show low-level nodular echoes and the borderline between

cortex and marrow disappears

The adrenal gland here are larger than 10 mm usually are only

moderately enlarged (to 2 cm)

Adrenal hyperplasia can occur for example as an adaptive

response in ACTH-dependent Cushing syndrome

It may have a paraneoplastic cause or it may occur in

hyperaldosteronism The hyperplasia is even bilateral in most

cases For the advanced examiner the adrenal glands are poorly

demarcated from their surroundings

Again CT provides a better view of the hyperplastic adrenal

glands which usually cannot be detected with ultrasound Also

the EUS on the left side shows the hyperplastic adrenal gland

better than transcutaneous ultrasound Differentiation to

adenoma normally is only possible by histology or cytology (so

FNB)

EUS shows on left side an enlarged proximal shank

of adrenal gland which occurs in nodular hyperplasia

Adrenal Cyst A cyst of the adrenal region is anechoic has smooth margins and shows distal acoustic enhancement Its extent is variable True cysts have regular walls and are filled with serous material

Round sharply circumscribed echo-free mass located dorsal

to the right liver and cranial to the right kidney adrenal cyst

Intra-adrenal Hemorrhage (Hematoma) Bleeding into an adrenal gland is anechoic in its early

stage It can occur in newborns due to obstetric trauma

hypoxia or coagulation disorders Intra-adrenal

hemorrhage may correlate clinically with adrenal

insufficiency

A large central hemorrhage (adrenal apoplexy)

consistently leads to the marked enlargement of the gland

An older hemorrhage becomes increasingly echogenic

over time and may eventually be completely absorbed

Differentiation is required from partially cystic neuroblastomas in small children

Up to 25 of patients who sustain blunt abdominal trauma are discovered to have hematomas in the adrenal region They also occur in patients on anticoagulant medication and can lead to hypocortisolism (Addison disease)

Cystic anechoic mass in the left adrenal gland representing a hemorrhage

Echo -free intra-adrenal hemorrhage in a

newborn with high resolution ultrasound

Adrenal Abscess An abscess of the adrenal glands is rarely anechoic It is usually hypoechoic

or has a complex echo structure When the contents are anechoic the clinical

and laboratory findings can differentiate the lesion from an ordinary cyst The

wall is irregular and distal acoustic enhancement may be present

Transverse ultrasound image reveals anechoic cystic masses containing internal echoes and debris at bilateral supra renal area and right is measuring more than left

Longitudinal ultrasound image reveals anechoic cystic abscess With wall calcification and needle in the lesion during procedure

Benign adrenal gland tumours Adenoma Adenomas are uniformly hypoechoic with smooth margins and a round to oval shape although some lesions have scalloped borders (polycyclic) Adenomas occasionally have an inhomogeneous appearance Autopsy statistics indicate that they are quite common (10ndash20) but most adenomas (90) produce no endocrine symptoms they are bdquosilentldquo and too small to be seen with ultrasound The average size of adenomas in one study was 15 cm although they may exceed 5 cm in diameter In a small percentage of patients adenomas are bilateral Functioning and nonfunctioning adenomas are indistinguishable by their sonographic features

Medial to the upper pole of the right kidney is a sharply circumscribed hypoechoic mass typical adrenal adenoma

Hypoechoic sharply circumscribed adenoma of the right adrenal gland discovered

at routine ultrasound (confirmed by ultrasound-guided fine-needle aspiration)

Approximately 5 cm hypoechoic inhomogenous mass above the right kidney adenoma (incidentaloma) without associated symptoms detected at routine upper abdominal ultrasound Histology identified as an adrenal adenoma (most common incidentaloma)

Lipoma Myelolipoma

Lipoma A pure lipoma of the adrenal glands has

smooth margins and high homogeneous

echogenicity In contrast to the mixed tissues of

myolipoma posterior acoustic shadowing does

not occur Lipoma is rare and shows no proliferative tendency

Myelolipoma Adrenal myelolipoma has smooth margins and a homogeneous hyperechoic structure It resembles a renal angiomyolipoma in its sonographic features Posterior acoustic shadowing is often present Malignant transformation is not known to occur The tumour consists histologically of fat and bone marrow tissue (hematopoietic cells and reticular cells) Intratumoral hemorrhage and calcifications may be seen

Homogeneous sharply circumscribed hyperechoic tumour adjacent to the right kidney Classic adrenal myelolipoma

In CEUS a myelolipoma shows a nearly constant

contrast enhancement without wash out

Calcification Complete or partial calcification of the adrenal glands is characterized by a

typical echo complex with a posterior acoustic shadow Calcifications can

result from a retained intra-adrenal hemorrhage or a prior inflammatory

process (eg tuberculosis) Patients occasionally show the clinical

manifestations of Addison disease However calcifications can also develop in

tumours (carcinoma metastases Pheochromocytoma adenoma)

In the proximal left kidney in the adrenal gland region wefound a classical calcification with dorsal acoustic shadow

Small calcifications also occur in tumours of adrenal gland most often observed in pheochromocytoma

Malignant adrenal gland tumours Metastases With their rich blood supply the adrenal glands are the fourth

most frequent site for hematogenous metastasis Metastases

to the adrenal glands account for the majority of solid adrenal

tumours after the adenomas

In contrast to adenomas these lesions are less homogeneous

and often have irregular margins The most common

primaries are bronchial carcinoma (25ndash30 ) breast

carcinoma and malignant melanoma Other possible sources

are gastrointestinal urological and gynecological tumours

(renal carcinoma gastric carcinoma pancreatic carcinoma

and others) Adrenal metastases are bilateral in up to 30 of

cases and this can produce the clinical manifestations of

Addison disease Bronchial carcinoma is virtually the only

tumour that is associated with isolated adrenal metastases

(in ca 15-20 )

Large metastasis from bronchial carcinoma on the right

side with a very inhomogeneous internal structure Solid

components are seen along with central liquid areas

Transverse scan shows a metastasis with a complex echo structure ldquowedgedrdquo between right lobe of the liver inferior vena cava the kidney and spinal column

Transverse scan of a metastasis of the right adrenal gland with complex structure beside a primary tumour of lung cancer

Partial metastases esp of lung cancer show

a wash out of contrast media in late phase

US examination longitudinal view Above the right kidney in the adrenal region a solid slightly inhomogeneous mass can be seen Neuroblastoma MRI examination

axial T2 weighted image Irregular large solid inhomogeneous retroperitoneal tumor

Pheochromocytoma Pheochromocytoma is a tumour of the adrenal medulla that is generally

detected sonographically (80ndash90 of cases) following the appearance

of clinical symptoms (hypertension and tachycardia caused by

increased catecholamine secretion)

Most pheochromocytomas are already several centimeters in diameter

when diagnosed They have smooth margins a round shape and a

nonhomogeneous or complex echo structure

Hypoechoic liquid components are also observed A spectrum of

appearances may be seen Pheochromocytomas are bilateral in

approximately 10 of cases and extra-adrenal in 10ndash20

The ldquoZuckerkandl organrdquo should be looked for at the level of the origin

of the inferior mesenteric artery anterior to the aorta

Other extra-adrenal sites are the renal hilum bladder wall and thorax

Pheochromocytoma is occasionally seen posterior to the renal vein in

transverse scans Rarely pheochromocytoma is diagnosed in the

setting of multiple endocrine neoplasia (MEN) From 2 to 5 of

pheochromocytomas are malignant Owing to the risk of inciting a

hypertensive crisis fine-needle aspiration biopsy causes discrepant

discussions about FNB

Nonhomogeneous tumour with a hyperechoic center (positive endocrine test increased catecholamine secretion) ndash Pheochromocytoma

Large functionally active pheochromocytoma (7 cm in diameter) The scan shows that most of tumour is hypoechoic with some hyperechoic regions

Lymphoma The adrenal region is a rare extranodal site of occurrence for lymphoma

Foci of lymphomatous infiltration have smooth borders and are

hypoechoic Differentiation is required from lymphomas in the renal or

splenic hilum If invasion by lymphoma is suspected other nodal

stations should be scanned and commonly infiltrated organs (spleen

liver) should be closely scrutinized

Perisplenic lymphoma in the left adrenal region of a patient with B-cell lymphoma

Colour Doppler shows hypervascularisation of the lymphatic tissue

Adrenal Carcinoma Adrenal carcinoma is usually inhomogeneous hypoechoic or echo complex with irregular margins It frequently infiltrates its surroundings and metastases can be demonstrated in the adrenal region and in other organs (eg the liver) The adrenal carcinoma is a very rare (1 17 million inhabitants) highly malignant tumour with a poor prognosis Adrenal carcinoma is indistinguishable sonographically from a metastasis although the visualization of additional tumours can advance the differential diagnosis Most adrenal carcinomas are hormone-producing Sometimes one can get evidence from detection of other tumour sign The tumour is usually detected only after it has reached considerable size (often gt8 cm) Intratumoral hemorrhage necrotic foci and calcifications may occur adding to the variegated appearance

Adrenal carcinoma may be hypoechoic or may have a complex echo structure Usually it

was relatively large when diagnosed (in this case 8 cm times 9 cm) and had irregular margins

Right adrenal adenocarcinoma A Sonogram showing a complex mass with cystic changes in the right adrenal gland (arrows) B Computed tomogram showing the mass (arrows)

Incidentaloma An incidentaloma is an adrenal tumour that is detected incidentally in an asymptomatic patient Incidentalomas are found in 1 of CT examinations They are much less common in ultrasound examinations because of the difficulty in defining small lesions (lt 2 cm) The predominantly hypoechoic tumours account for the great majority of incidentalomas shows the algorithm used in the investigation of incidentalomas Approximately 10 to 15 of these tumours are hormonally active In some cases ultrasound-guided fine-needle aspiration can also aid in the evaluation of incidentalomas but only ca 1 to 2 of these tumours are malignant

Abdominal ultrasound examination incidentally found most hypoechoic lesions

smaller 2 cm without clinical symptoms ndash which is typical for incidentalomas

Histoplasmosis is a geographically restricted form of

fungal infection Adrenal involvement is seen in disseminated disease but sometimes it may be the only site of demonstrable disease Early diagnosis and treatment may save the patient from catastrophic adrenal insufficiency We present two patients showing bilateral adrenomegaly on ultrasonography and contrast-enhanced CT and was diagnosed to have histoplasmosis on fine-needle aspiration cytology

Histoplasmosis is an infective condition caused by a

dimorphic saprophytic fungus Histoplasma capsulatum and is acquired by inhalation of its spores Soil rich in bird and bat dropping is its natural habitat and it exists as a mycelium in the atmosphere

Both adrenal gland were enlarged and hypoechoic at US study

US show bilateral hypoechoic lesions and CT showed peripherally enhancing hypodense bilateral adrenals with peripheral rim and septate enhancement

ULTRASOUND OF THE ADULT KIDNEY ndash Normal

Coronal scan plane for the Right Kidney Longitudinal Normal Kidney

Scan plane transverse kidney Transverse normal image

Common anatomical variantsAtrophic small kidneyHorseshoe kidneyEctopic kidneyDuplex kidneyCross fused ectopiaUnilateral renal agenesis

COMMON PATHOLOGYCalculusRenal cyst Cortical and Para-pelvicAngiomyolipmaRenal infectionRenal cell carcinomaTransitional cell carcinomaMedullary sponge kidneyPolycystic kidney disease

Horseshoe kidney A transverse and longitudinal view across the midline showing the isthmus across the aorta

Cross fused ectopic kidney The left kidney is fused to the lower pole of the right kidney

A baggy extra-renal pelvis

Pelvic ectopic kidney

UltrasonographyOn sonograms stones are demonstrated as bright echogenic foci with posterior acoustic shadowing Stones are visualized fairly well with US in the kidneys and the distal ureter at or near the UVJ especially if dilatation is present US is good for the visualization of complications such as hydronephrosis (or other signs of obstruction) however some patients with acute obstruction have little or no dilationIn particular US is helpful in evaluating those with renal insufficiency or contraindications for the use of contrast media however US is often skipped in favor of nonenhanced CTIn addition US is good for characterizing lucent filling defects that are visualized as stones on IVU However US does not provide direct physiologic information regarding the degree of obstruction Doppler imaging may demonstrate a high resistive index in acute obstruction but this may not occur immediately or after forniceal rupture Absence of the ureteral jet as visualized with color Doppler on the symptomatic side is presumptive evidence for a high-grade obstruction in a well-hydrated patient

Degree of confidenceUS is very insensitive for stones especially stones smaller than 2 mm stones at the UPJ or stones in the mid ureter Fowler et al suggest that US has a sensitivity as low as 24 compared with nonenhanced CT Furthermore estimations of stone size may not be accurate Compared with nonenhanced CT US is more dependent on the operators ability and more time consuming

False positivesnegativesUS is fairly specific when stones are seen with a specificity as high as 90 With US matrix or indinavir stones may have soft tissue echogenicity without shadowing False-positive findings may result from renal vascular calcifications False-positive diagnoses of hydronephrosis also result from dilated vascular structures in the renal hilum Doppler imaging is helpful in distinguishing dilated vascular structures from hydronephrosis

Renal sonogram demonstrates an echogenic shadowing calculus in the renal collecting system with hydronephrosis

US images for renal stones

US images of staghorn stones

US images for ureteric stones

US images for nephrocalcinosis

Renal cystA renal cyst is a fluid collection in the kidney There are several types based on the Bosniak classification The majority are benign simple cysts that can be monitored and not intervened upon However some are cancerous or are suspicious for cancer and are commonly removed in a surgical procedure called nephrectomyNumerous renal cysts are seen in the cystic kidney diseases which include polycystic kidney diseaseand medullary sponge kidney

The Bosniak classification categorizes renal cysts into five groupsCategory I

Benign simple cyst with thin wall without septa calcifications or solid

components

It does not enhance with contrast and has a density equal to that of water

Category IIBenign cyst with a few thin septa which may contain fine calcifications or a

small

segment of mildly thickened calcification This includes homogenous

high-attenuation lesions less than 3 cm with sharp margins(Rich Kosak) but

without enhancement

Category IIFWell marginated cysts with a number of thin septa with or without mild

enhancement or thickening of septa Calcifications may be present these

may be thick and nodular There are no enhancing soft tissue components

This also includes nonenhancing high-attenuation lesions that are completely

contained within the kidney and are 3 cm or larger

Category IIIIndeterminate cystic masses with thickened irregular septa with enhancement

Category IVMalignant cystic masses with all the characteristics of category III lesions

but also with enhancing soft tissue components independent of but adjacent

to the septa

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 11)

Classic findings of a simple cyst(Bosniak category 111)

Classic findings of a simple cyst(Bosniak category 1V)

Para-pelvic cyst USamp CT images

US of polycystic kidney disease

Renal infection

US of acute pyelonephritis

Acute bacterial pyelonephritis (a) US scan shows a wedge-shaped hyperechoic focus (arrowhead) in the upper pole of the right kidney related to acute bacterial pyelonephritis (b) Color flow US image demonstrates diminished flow through the involved area

US and color Doppler images of right kidney shows focal hyperechoic nephritis with decreased perfusion at the Doppler US

US and color Doppler images of kidney shows two multifocal nephritis with decreased perfusion at the Doppler US

Masslike appearance of acute bacterial pyelonephritis US and CT images

Emphysematous pyelonephritis (a) US image shows nondependent echoes within the left kidney that demonstrate a ring-down artifact (b) Corresponding CT scan helps confirm that this pattern is caused by intraparenchymal air

Xanthogranulomatous pyelonephritis (a) Contrast-enhanced CT scan demonstrates bilateral staghorn calculi with distention of the right collecting system secondary to inflammatory debris (b) US scan also shows the dilated

collecting system (arrowheads) and a shadowing calculus (arrow)

Early and mature abscess cavities (a) US scan demonstrates a geographic hypoechoic focus from an abscess in the upper pole of the right kidney (b) On a US scan of a more mature abscess the cavity is better defined with a visible pseudocapsule and through transmission that is evidenced by increased echogenicity deep to the upper pole lesion

Pyohydronephrosis

Pyohydronephrosis

Renal hydatidosis is an insidious disease and patients

often present with nonspecific clinical signs or symptoms Presenting complaints are dull flank pain hematuria palpable flank mass hypertension and renal colic

Disseminated abdominal retroperitoneal and pelvic hydatid disease (a) The right kidney is pushed to the midline and the left kidney is hydronephrotic and shrunken by retroperitoneal hydatid cysts (b) Ultrasound of the abdomen showing cystic lesions in the retroperitoneum in the position of the kidneys

Hydatid disease of the kidney US and CT images

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 5: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Sonoanatomy of the left adrenal gland - image by high resolution endosonography The proximal and the caudal limbs are visible in high resolution quality and the adrenal gland-marrow is more echorich

Adrenal gland hyperplasia Hyperplastic adrenal glands are usually hypoechoic especially

in the cortical zone They appear plump and elongated may

show low-level nodular echoes and the borderline between

cortex and marrow disappears

The adrenal gland here are larger than 10 mm usually are only

moderately enlarged (to 2 cm)

Adrenal hyperplasia can occur for example as an adaptive

response in ACTH-dependent Cushing syndrome

It may have a paraneoplastic cause or it may occur in

hyperaldosteronism The hyperplasia is even bilateral in most

cases For the advanced examiner the adrenal glands are poorly

demarcated from their surroundings

Again CT provides a better view of the hyperplastic adrenal

glands which usually cannot be detected with ultrasound Also

the EUS on the left side shows the hyperplastic adrenal gland

better than transcutaneous ultrasound Differentiation to

adenoma normally is only possible by histology or cytology (so

FNB)

EUS shows on left side an enlarged proximal shank

of adrenal gland which occurs in nodular hyperplasia

Adrenal Cyst A cyst of the adrenal region is anechoic has smooth margins and shows distal acoustic enhancement Its extent is variable True cysts have regular walls and are filled with serous material

Round sharply circumscribed echo-free mass located dorsal

to the right liver and cranial to the right kidney adrenal cyst

Intra-adrenal Hemorrhage (Hematoma) Bleeding into an adrenal gland is anechoic in its early

stage It can occur in newborns due to obstetric trauma

hypoxia or coagulation disorders Intra-adrenal

hemorrhage may correlate clinically with adrenal

insufficiency

A large central hemorrhage (adrenal apoplexy)

consistently leads to the marked enlargement of the gland

An older hemorrhage becomes increasingly echogenic

over time and may eventually be completely absorbed

Differentiation is required from partially cystic neuroblastomas in small children

Up to 25 of patients who sustain blunt abdominal trauma are discovered to have hematomas in the adrenal region They also occur in patients on anticoagulant medication and can lead to hypocortisolism (Addison disease)

Cystic anechoic mass in the left adrenal gland representing a hemorrhage

Echo -free intra-adrenal hemorrhage in a

newborn with high resolution ultrasound

Adrenal Abscess An abscess of the adrenal glands is rarely anechoic It is usually hypoechoic

or has a complex echo structure When the contents are anechoic the clinical

and laboratory findings can differentiate the lesion from an ordinary cyst The

wall is irregular and distal acoustic enhancement may be present

Transverse ultrasound image reveals anechoic cystic masses containing internal echoes and debris at bilateral supra renal area and right is measuring more than left

Longitudinal ultrasound image reveals anechoic cystic abscess With wall calcification and needle in the lesion during procedure

Benign adrenal gland tumours Adenoma Adenomas are uniformly hypoechoic with smooth margins and a round to oval shape although some lesions have scalloped borders (polycyclic) Adenomas occasionally have an inhomogeneous appearance Autopsy statistics indicate that they are quite common (10ndash20) but most adenomas (90) produce no endocrine symptoms they are bdquosilentldquo and too small to be seen with ultrasound The average size of adenomas in one study was 15 cm although they may exceed 5 cm in diameter In a small percentage of patients adenomas are bilateral Functioning and nonfunctioning adenomas are indistinguishable by their sonographic features

Medial to the upper pole of the right kidney is a sharply circumscribed hypoechoic mass typical adrenal adenoma

Hypoechoic sharply circumscribed adenoma of the right adrenal gland discovered

at routine ultrasound (confirmed by ultrasound-guided fine-needle aspiration)

Approximately 5 cm hypoechoic inhomogenous mass above the right kidney adenoma (incidentaloma) without associated symptoms detected at routine upper abdominal ultrasound Histology identified as an adrenal adenoma (most common incidentaloma)

Lipoma Myelolipoma

Lipoma A pure lipoma of the adrenal glands has

smooth margins and high homogeneous

echogenicity In contrast to the mixed tissues of

myolipoma posterior acoustic shadowing does

not occur Lipoma is rare and shows no proliferative tendency

Myelolipoma Adrenal myelolipoma has smooth margins and a homogeneous hyperechoic structure It resembles a renal angiomyolipoma in its sonographic features Posterior acoustic shadowing is often present Malignant transformation is not known to occur The tumour consists histologically of fat and bone marrow tissue (hematopoietic cells and reticular cells) Intratumoral hemorrhage and calcifications may be seen

Homogeneous sharply circumscribed hyperechoic tumour adjacent to the right kidney Classic adrenal myelolipoma

In CEUS a myelolipoma shows a nearly constant

contrast enhancement without wash out

Calcification Complete or partial calcification of the adrenal glands is characterized by a

typical echo complex with a posterior acoustic shadow Calcifications can

result from a retained intra-adrenal hemorrhage or a prior inflammatory

process (eg tuberculosis) Patients occasionally show the clinical

manifestations of Addison disease However calcifications can also develop in

tumours (carcinoma metastases Pheochromocytoma adenoma)

In the proximal left kidney in the adrenal gland region wefound a classical calcification with dorsal acoustic shadow

Small calcifications also occur in tumours of adrenal gland most often observed in pheochromocytoma

Malignant adrenal gland tumours Metastases With their rich blood supply the adrenal glands are the fourth

most frequent site for hematogenous metastasis Metastases

to the adrenal glands account for the majority of solid adrenal

tumours after the adenomas

In contrast to adenomas these lesions are less homogeneous

and often have irregular margins The most common

primaries are bronchial carcinoma (25ndash30 ) breast

carcinoma and malignant melanoma Other possible sources

are gastrointestinal urological and gynecological tumours

(renal carcinoma gastric carcinoma pancreatic carcinoma

and others) Adrenal metastases are bilateral in up to 30 of

cases and this can produce the clinical manifestations of

Addison disease Bronchial carcinoma is virtually the only

tumour that is associated with isolated adrenal metastases

(in ca 15-20 )

Large metastasis from bronchial carcinoma on the right

side with a very inhomogeneous internal structure Solid

components are seen along with central liquid areas

Transverse scan shows a metastasis with a complex echo structure ldquowedgedrdquo between right lobe of the liver inferior vena cava the kidney and spinal column

Transverse scan of a metastasis of the right adrenal gland with complex structure beside a primary tumour of lung cancer

Partial metastases esp of lung cancer show

a wash out of contrast media in late phase

US examination longitudinal view Above the right kidney in the adrenal region a solid slightly inhomogeneous mass can be seen Neuroblastoma MRI examination

axial T2 weighted image Irregular large solid inhomogeneous retroperitoneal tumor

Pheochromocytoma Pheochromocytoma is a tumour of the adrenal medulla that is generally

detected sonographically (80ndash90 of cases) following the appearance

of clinical symptoms (hypertension and tachycardia caused by

increased catecholamine secretion)

Most pheochromocytomas are already several centimeters in diameter

when diagnosed They have smooth margins a round shape and a

nonhomogeneous or complex echo structure

Hypoechoic liquid components are also observed A spectrum of

appearances may be seen Pheochromocytomas are bilateral in

approximately 10 of cases and extra-adrenal in 10ndash20

The ldquoZuckerkandl organrdquo should be looked for at the level of the origin

of the inferior mesenteric artery anterior to the aorta

Other extra-adrenal sites are the renal hilum bladder wall and thorax

Pheochromocytoma is occasionally seen posterior to the renal vein in

transverse scans Rarely pheochromocytoma is diagnosed in the

setting of multiple endocrine neoplasia (MEN) From 2 to 5 of

pheochromocytomas are malignant Owing to the risk of inciting a

hypertensive crisis fine-needle aspiration biopsy causes discrepant

discussions about FNB

Nonhomogeneous tumour with a hyperechoic center (positive endocrine test increased catecholamine secretion) ndash Pheochromocytoma

Large functionally active pheochromocytoma (7 cm in diameter) The scan shows that most of tumour is hypoechoic with some hyperechoic regions

Lymphoma The adrenal region is a rare extranodal site of occurrence for lymphoma

Foci of lymphomatous infiltration have smooth borders and are

hypoechoic Differentiation is required from lymphomas in the renal or

splenic hilum If invasion by lymphoma is suspected other nodal

stations should be scanned and commonly infiltrated organs (spleen

liver) should be closely scrutinized

Perisplenic lymphoma in the left adrenal region of a patient with B-cell lymphoma

Colour Doppler shows hypervascularisation of the lymphatic tissue

Adrenal Carcinoma Adrenal carcinoma is usually inhomogeneous hypoechoic or echo complex with irregular margins It frequently infiltrates its surroundings and metastases can be demonstrated in the adrenal region and in other organs (eg the liver) The adrenal carcinoma is a very rare (1 17 million inhabitants) highly malignant tumour with a poor prognosis Adrenal carcinoma is indistinguishable sonographically from a metastasis although the visualization of additional tumours can advance the differential diagnosis Most adrenal carcinomas are hormone-producing Sometimes one can get evidence from detection of other tumour sign The tumour is usually detected only after it has reached considerable size (often gt8 cm) Intratumoral hemorrhage necrotic foci and calcifications may occur adding to the variegated appearance

Adrenal carcinoma may be hypoechoic or may have a complex echo structure Usually it

was relatively large when diagnosed (in this case 8 cm times 9 cm) and had irregular margins

Right adrenal adenocarcinoma A Sonogram showing a complex mass with cystic changes in the right adrenal gland (arrows) B Computed tomogram showing the mass (arrows)

Incidentaloma An incidentaloma is an adrenal tumour that is detected incidentally in an asymptomatic patient Incidentalomas are found in 1 of CT examinations They are much less common in ultrasound examinations because of the difficulty in defining small lesions (lt 2 cm) The predominantly hypoechoic tumours account for the great majority of incidentalomas shows the algorithm used in the investigation of incidentalomas Approximately 10 to 15 of these tumours are hormonally active In some cases ultrasound-guided fine-needle aspiration can also aid in the evaluation of incidentalomas but only ca 1 to 2 of these tumours are malignant

Abdominal ultrasound examination incidentally found most hypoechoic lesions

smaller 2 cm without clinical symptoms ndash which is typical for incidentalomas

Histoplasmosis is a geographically restricted form of

fungal infection Adrenal involvement is seen in disseminated disease but sometimes it may be the only site of demonstrable disease Early diagnosis and treatment may save the patient from catastrophic adrenal insufficiency We present two patients showing bilateral adrenomegaly on ultrasonography and contrast-enhanced CT and was diagnosed to have histoplasmosis on fine-needle aspiration cytology

Histoplasmosis is an infective condition caused by a

dimorphic saprophytic fungus Histoplasma capsulatum and is acquired by inhalation of its spores Soil rich in bird and bat dropping is its natural habitat and it exists as a mycelium in the atmosphere

Both adrenal gland were enlarged and hypoechoic at US study

US show bilateral hypoechoic lesions and CT showed peripherally enhancing hypodense bilateral adrenals with peripheral rim and septate enhancement

ULTRASOUND OF THE ADULT KIDNEY ndash Normal

Coronal scan plane for the Right Kidney Longitudinal Normal Kidney

Scan plane transverse kidney Transverse normal image

Common anatomical variantsAtrophic small kidneyHorseshoe kidneyEctopic kidneyDuplex kidneyCross fused ectopiaUnilateral renal agenesis

COMMON PATHOLOGYCalculusRenal cyst Cortical and Para-pelvicAngiomyolipmaRenal infectionRenal cell carcinomaTransitional cell carcinomaMedullary sponge kidneyPolycystic kidney disease

Horseshoe kidney A transverse and longitudinal view across the midline showing the isthmus across the aorta

Cross fused ectopic kidney The left kidney is fused to the lower pole of the right kidney

A baggy extra-renal pelvis

Pelvic ectopic kidney

UltrasonographyOn sonograms stones are demonstrated as bright echogenic foci with posterior acoustic shadowing Stones are visualized fairly well with US in the kidneys and the distal ureter at or near the UVJ especially if dilatation is present US is good for the visualization of complications such as hydronephrosis (or other signs of obstruction) however some patients with acute obstruction have little or no dilationIn particular US is helpful in evaluating those with renal insufficiency or contraindications for the use of contrast media however US is often skipped in favor of nonenhanced CTIn addition US is good for characterizing lucent filling defects that are visualized as stones on IVU However US does not provide direct physiologic information regarding the degree of obstruction Doppler imaging may demonstrate a high resistive index in acute obstruction but this may not occur immediately or after forniceal rupture Absence of the ureteral jet as visualized with color Doppler on the symptomatic side is presumptive evidence for a high-grade obstruction in a well-hydrated patient

Degree of confidenceUS is very insensitive for stones especially stones smaller than 2 mm stones at the UPJ or stones in the mid ureter Fowler et al suggest that US has a sensitivity as low as 24 compared with nonenhanced CT Furthermore estimations of stone size may not be accurate Compared with nonenhanced CT US is more dependent on the operators ability and more time consuming

False positivesnegativesUS is fairly specific when stones are seen with a specificity as high as 90 With US matrix or indinavir stones may have soft tissue echogenicity without shadowing False-positive findings may result from renal vascular calcifications False-positive diagnoses of hydronephrosis also result from dilated vascular structures in the renal hilum Doppler imaging is helpful in distinguishing dilated vascular structures from hydronephrosis

Renal sonogram demonstrates an echogenic shadowing calculus in the renal collecting system with hydronephrosis

US images for renal stones

US images of staghorn stones

US images for ureteric stones

US images for nephrocalcinosis

Renal cystA renal cyst is a fluid collection in the kidney There are several types based on the Bosniak classification The majority are benign simple cysts that can be monitored and not intervened upon However some are cancerous or are suspicious for cancer and are commonly removed in a surgical procedure called nephrectomyNumerous renal cysts are seen in the cystic kidney diseases which include polycystic kidney diseaseand medullary sponge kidney

The Bosniak classification categorizes renal cysts into five groupsCategory I

Benign simple cyst with thin wall without septa calcifications or solid

components

It does not enhance with contrast and has a density equal to that of water

Category IIBenign cyst with a few thin septa which may contain fine calcifications or a

small

segment of mildly thickened calcification This includes homogenous

high-attenuation lesions less than 3 cm with sharp margins(Rich Kosak) but

without enhancement

Category IIFWell marginated cysts with a number of thin septa with or without mild

enhancement or thickening of septa Calcifications may be present these

may be thick and nodular There are no enhancing soft tissue components

This also includes nonenhancing high-attenuation lesions that are completely

contained within the kidney and are 3 cm or larger

Category IIIIndeterminate cystic masses with thickened irregular septa with enhancement

Category IVMalignant cystic masses with all the characteristics of category III lesions

but also with enhancing soft tissue components independent of but adjacent

to the septa

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 11)

Classic findings of a simple cyst(Bosniak category 111)

Classic findings of a simple cyst(Bosniak category 1V)

Para-pelvic cyst USamp CT images

US of polycystic kidney disease

Renal infection

US of acute pyelonephritis

Acute bacterial pyelonephritis (a) US scan shows a wedge-shaped hyperechoic focus (arrowhead) in the upper pole of the right kidney related to acute bacterial pyelonephritis (b) Color flow US image demonstrates diminished flow through the involved area

US and color Doppler images of right kidney shows focal hyperechoic nephritis with decreased perfusion at the Doppler US

US and color Doppler images of kidney shows two multifocal nephritis with decreased perfusion at the Doppler US

Masslike appearance of acute bacterial pyelonephritis US and CT images

Emphysematous pyelonephritis (a) US image shows nondependent echoes within the left kidney that demonstrate a ring-down artifact (b) Corresponding CT scan helps confirm that this pattern is caused by intraparenchymal air

Xanthogranulomatous pyelonephritis (a) Contrast-enhanced CT scan demonstrates bilateral staghorn calculi with distention of the right collecting system secondary to inflammatory debris (b) US scan also shows the dilated

collecting system (arrowheads) and a shadowing calculus (arrow)

Early and mature abscess cavities (a) US scan demonstrates a geographic hypoechoic focus from an abscess in the upper pole of the right kidney (b) On a US scan of a more mature abscess the cavity is better defined with a visible pseudocapsule and through transmission that is evidenced by increased echogenicity deep to the upper pole lesion

Pyohydronephrosis

Pyohydronephrosis

Renal hydatidosis is an insidious disease and patients

often present with nonspecific clinical signs or symptoms Presenting complaints are dull flank pain hematuria palpable flank mass hypertension and renal colic

Disseminated abdominal retroperitoneal and pelvic hydatid disease (a) The right kidney is pushed to the midline and the left kidney is hydronephrotic and shrunken by retroperitoneal hydatid cysts (b) Ultrasound of the abdomen showing cystic lesions in the retroperitoneum in the position of the kidneys

Hydatid disease of the kidney US and CT images

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 6: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Adrenal gland hyperplasia Hyperplastic adrenal glands are usually hypoechoic especially

in the cortical zone They appear plump and elongated may

show low-level nodular echoes and the borderline between

cortex and marrow disappears

The adrenal gland here are larger than 10 mm usually are only

moderately enlarged (to 2 cm)

Adrenal hyperplasia can occur for example as an adaptive

response in ACTH-dependent Cushing syndrome

It may have a paraneoplastic cause or it may occur in

hyperaldosteronism The hyperplasia is even bilateral in most

cases For the advanced examiner the adrenal glands are poorly

demarcated from their surroundings

Again CT provides a better view of the hyperplastic adrenal

glands which usually cannot be detected with ultrasound Also

the EUS on the left side shows the hyperplastic adrenal gland

better than transcutaneous ultrasound Differentiation to

adenoma normally is only possible by histology or cytology (so

FNB)

EUS shows on left side an enlarged proximal shank

of adrenal gland which occurs in nodular hyperplasia

Adrenal Cyst A cyst of the adrenal region is anechoic has smooth margins and shows distal acoustic enhancement Its extent is variable True cysts have regular walls and are filled with serous material

Round sharply circumscribed echo-free mass located dorsal

to the right liver and cranial to the right kidney adrenal cyst

Intra-adrenal Hemorrhage (Hematoma) Bleeding into an adrenal gland is anechoic in its early

stage It can occur in newborns due to obstetric trauma

hypoxia or coagulation disorders Intra-adrenal

hemorrhage may correlate clinically with adrenal

insufficiency

A large central hemorrhage (adrenal apoplexy)

consistently leads to the marked enlargement of the gland

An older hemorrhage becomes increasingly echogenic

over time and may eventually be completely absorbed

Differentiation is required from partially cystic neuroblastomas in small children

Up to 25 of patients who sustain blunt abdominal trauma are discovered to have hematomas in the adrenal region They also occur in patients on anticoagulant medication and can lead to hypocortisolism (Addison disease)

Cystic anechoic mass in the left adrenal gland representing a hemorrhage

Echo -free intra-adrenal hemorrhage in a

newborn with high resolution ultrasound

Adrenal Abscess An abscess of the adrenal glands is rarely anechoic It is usually hypoechoic

or has a complex echo structure When the contents are anechoic the clinical

and laboratory findings can differentiate the lesion from an ordinary cyst The

wall is irregular and distal acoustic enhancement may be present

Transverse ultrasound image reveals anechoic cystic masses containing internal echoes and debris at bilateral supra renal area and right is measuring more than left

Longitudinal ultrasound image reveals anechoic cystic abscess With wall calcification and needle in the lesion during procedure

Benign adrenal gland tumours Adenoma Adenomas are uniformly hypoechoic with smooth margins and a round to oval shape although some lesions have scalloped borders (polycyclic) Adenomas occasionally have an inhomogeneous appearance Autopsy statistics indicate that they are quite common (10ndash20) but most adenomas (90) produce no endocrine symptoms they are bdquosilentldquo and too small to be seen with ultrasound The average size of adenomas in one study was 15 cm although they may exceed 5 cm in diameter In a small percentage of patients adenomas are bilateral Functioning and nonfunctioning adenomas are indistinguishable by their sonographic features

Medial to the upper pole of the right kidney is a sharply circumscribed hypoechoic mass typical adrenal adenoma

Hypoechoic sharply circumscribed adenoma of the right adrenal gland discovered

at routine ultrasound (confirmed by ultrasound-guided fine-needle aspiration)

Approximately 5 cm hypoechoic inhomogenous mass above the right kidney adenoma (incidentaloma) without associated symptoms detected at routine upper abdominal ultrasound Histology identified as an adrenal adenoma (most common incidentaloma)

Lipoma Myelolipoma

Lipoma A pure lipoma of the adrenal glands has

smooth margins and high homogeneous

echogenicity In contrast to the mixed tissues of

myolipoma posterior acoustic shadowing does

not occur Lipoma is rare and shows no proliferative tendency

Myelolipoma Adrenal myelolipoma has smooth margins and a homogeneous hyperechoic structure It resembles a renal angiomyolipoma in its sonographic features Posterior acoustic shadowing is often present Malignant transformation is not known to occur The tumour consists histologically of fat and bone marrow tissue (hematopoietic cells and reticular cells) Intratumoral hemorrhage and calcifications may be seen

Homogeneous sharply circumscribed hyperechoic tumour adjacent to the right kidney Classic adrenal myelolipoma

In CEUS a myelolipoma shows a nearly constant

contrast enhancement without wash out

Calcification Complete or partial calcification of the adrenal glands is characterized by a

typical echo complex with a posterior acoustic shadow Calcifications can

result from a retained intra-adrenal hemorrhage or a prior inflammatory

process (eg tuberculosis) Patients occasionally show the clinical

manifestations of Addison disease However calcifications can also develop in

tumours (carcinoma metastases Pheochromocytoma adenoma)

In the proximal left kidney in the adrenal gland region wefound a classical calcification with dorsal acoustic shadow

Small calcifications also occur in tumours of adrenal gland most often observed in pheochromocytoma

Malignant adrenal gland tumours Metastases With their rich blood supply the adrenal glands are the fourth

most frequent site for hematogenous metastasis Metastases

to the adrenal glands account for the majority of solid adrenal

tumours after the adenomas

In contrast to adenomas these lesions are less homogeneous

and often have irregular margins The most common

primaries are bronchial carcinoma (25ndash30 ) breast

carcinoma and malignant melanoma Other possible sources

are gastrointestinal urological and gynecological tumours

(renal carcinoma gastric carcinoma pancreatic carcinoma

and others) Adrenal metastases are bilateral in up to 30 of

cases and this can produce the clinical manifestations of

Addison disease Bronchial carcinoma is virtually the only

tumour that is associated with isolated adrenal metastases

(in ca 15-20 )

Large metastasis from bronchial carcinoma on the right

side with a very inhomogeneous internal structure Solid

components are seen along with central liquid areas

Transverse scan shows a metastasis with a complex echo structure ldquowedgedrdquo between right lobe of the liver inferior vena cava the kidney and spinal column

Transverse scan of a metastasis of the right adrenal gland with complex structure beside a primary tumour of lung cancer

Partial metastases esp of lung cancer show

a wash out of contrast media in late phase

US examination longitudinal view Above the right kidney in the adrenal region a solid slightly inhomogeneous mass can be seen Neuroblastoma MRI examination

axial T2 weighted image Irregular large solid inhomogeneous retroperitoneal tumor

Pheochromocytoma Pheochromocytoma is a tumour of the adrenal medulla that is generally

detected sonographically (80ndash90 of cases) following the appearance

of clinical symptoms (hypertension and tachycardia caused by

increased catecholamine secretion)

Most pheochromocytomas are already several centimeters in diameter

when diagnosed They have smooth margins a round shape and a

nonhomogeneous or complex echo structure

Hypoechoic liquid components are also observed A spectrum of

appearances may be seen Pheochromocytomas are bilateral in

approximately 10 of cases and extra-adrenal in 10ndash20

The ldquoZuckerkandl organrdquo should be looked for at the level of the origin

of the inferior mesenteric artery anterior to the aorta

Other extra-adrenal sites are the renal hilum bladder wall and thorax

Pheochromocytoma is occasionally seen posterior to the renal vein in

transverse scans Rarely pheochromocytoma is diagnosed in the

setting of multiple endocrine neoplasia (MEN) From 2 to 5 of

pheochromocytomas are malignant Owing to the risk of inciting a

hypertensive crisis fine-needle aspiration biopsy causes discrepant

discussions about FNB

Nonhomogeneous tumour with a hyperechoic center (positive endocrine test increased catecholamine secretion) ndash Pheochromocytoma

Large functionally active pheochromocytoma (7 cm in diameter) The scan shows that most of tumour is hypoechoic with some hyperechoic regions

Lymphoma The adrenal region is a rare extranodal site of occurrence for lymphoma

Foci of lymphomatous infiltration have smooth borders and are

hypoechoic Differentiation is required from lymphomas in the renal or

splenic hilum If invasion by lymphoma is suspected other nodal

stations should be scanned and commonly infiltrated organs (spleen

liver) should be closely scrutinized

Perisplenic lymphoma in the left adrenal region of a patient with B-cell lymphoma

Colour Doppler shows hypervascularisation of the lymphatic tissue

Adrenal Carcinoma Adrenal carcinoma is usually inhomogeneous hypoechoic or echo complex with irregular margins It frequently infiltrates its surroundings and metastases can be demonstrated in the adrenal region and in other organs (eg the liver) The adrenal carcinoma is a very rare (1 17 million inhabitants) highly malignant tumour with a poor prognosis Adrenal carcinoma is indistinguishable sonographically from a metastasis although the visualization of additional tumours can advance the differential diagnosis Most adrenal carcinomas are hormone-producing Sometimes one can get evidence from detection of other tumour sign The tumour is usually detected only after it has reached considerable size (often gt8 cm) Intratumoral hemorrhage necrotic foci and calcifications may occur adding to the variegated appearance

Adrenal carcinoma may be hypoechoic or may have a complex echo structure Usually it

was relatively large when diagnosed (in this case 8 cm times 9 cm) and had irregular margins

Right adrenal adenocarcinoma A Sonogram showing a complex mass with cystic changes in the right adrenal gland (arrows) B Computed tomogram showing the mass (arrows)

Incidentaloma An incidentaloma is an adrenal tumour that is detected incidentally in an asymptomatic patient Incidentalomas are found in 1 of CT examinations They are much less common in ultrasound examinations because of the difficulty in defining small lesions (lt 2 cm) The predominantly hypoechoic tumours account for the great majority of incidentalomas shows the algorithm used in the investigation of incidentalomas Approximately 10 to 15 of these tumours are hormonally active In some cases ultrasound-guided fine-needle aspiration can also aid in the evaluation of incidentalomas but only ca 1 to 2 of these tumours are malignant

Abdominal ultrasound examination incidentally found most hypoechoic lesions

smaller 2 cm without clinical symptoms ndash which is typical for incidentalomas

Histoplasmosis is a geographically restricted form of

fungal infection Adrenal involvement is seen in disseminated disease but sometimes it may be the only site of demonstrable disease Early diagnosis and treatment may save the patient from catastrophic adrenal insufficiency We present two patients showing bilateral adrenomegaly on ultrasonography and contrast-enhanced CT and was diagnosed to have histoplasmosis on fine-needle aspiration cytology

Histoplasmosis is an infective condition caused by a

dimorphic saprophytic fungus Histoplasma capsulatum and is acquired by inhalation of its spores Soil rich in bird and bat dropping is its natural habitat and it exists as a mycelium in the atmosphere

Both adrenal gland were enlarged and hypoechoic at US study

US show bilateral hypoechoic lesions and CT showed peripherally enhancing hypodense bilateral adrenals with peripheral rim and septate enhancement

ULTRASOUND OF THE ADULT KIDNEY ndash Normal

Coronal scan plane for the Right Kidney Longitudinal Normal Kidney

Scan plane transverse kidney Transverse normal image

Common anatomical variantsAtrophic small kidneyHorseshoe kidneyEctopic kidneyDuplex kidneyCross fused ectopiaUnilateral renal agenesis

COMMON PATHOLOGYCalculusRenal cyst Cortical and Para-pelvicAngiomyolipmaRenal infectionRenal cell carcinomaTransitional cell carcinomaMedullary sponge kidneyPolycystic kidney disease

Horseshoe kidney A transverse and longitudinal view across the midline showing the isthmus across the aorta

Cross fused ectopic kidney The left kidney is fused to the lower pole of the right kidney

A baggy extra-renal pelvis

Pelvic ectopic kidney

UltrasonographyOn sonograms stones are demonstrated as bright echogenic foci with posterior acoustic shadowing Stones are visualized fairly well with US in the kidneys and the distal ureter at or near the UVJ especially if dilatation is present US is good for the visualization of complications such as hydronephrosis (or other signs of obstruction) however some patients with acute obstruction have little or no dilationIn particular US is helpful in evaluating those with renal insufficiency or contraindications for the use of contrast media however US is often skipped in favor of nonenhanced CTIn addition US is good for characterizing lucent filling defects that are visualized as stones on IVU However US does not provide direct physiologic information regarding the degree of obstruction Doppler imaging may demonstrate a high resistive index in acute obstruction but this may not occur immediately or after forniceal rupture Absence of the ureteral jet as visualized with color Doppler on the symptomatic side is presumptive evidence for a high-grade obstruction in a well-hydrated patient

Degree of confidenceUS is very insensitive for stones especially stones smaller than 2 mm stones at the UPJ or stones in the mid ureter Fowler et al suggest that US has a sensitivity as low as 24 compared with nonenhanced CT Furthermore estimations of stone size may not be accurate Compared with nonenhanced CT US is more dependent on the operators ability and more time consuming

False positivesnegativesUS is fairly specific when stones are seen with a specificity as high as 90 With US matrix or indinavir stones may have soft tissue echogenicity without shadowing False-positive findings may result from renal vascular calcifications False-positive diagnoses of hydronephrosis also result from dilated vascular structures in the renal hilum Doppler imaging is helpful in distinguishing dilated vascular structures from hydronephrosis

Renal sonogram demonstrates an echogenic shadowing calculus in the renal collecting system with hydronephrosis

US images for renal stones

US images of staghorn stones

US images for ureteric stones

US images for nephrocalcinosis

Renal cystA renal cyst is a fluid collection in the kidney There are several types based on the Bosniak classification The majority are benign simple cysts that can be monitored and not intervened upon However some are cancerous or are suspicious for cancer and are commonly removed in a surgical procedure called nephrectomyNumerous renal cysts are seen in the cystic kidney diseases which include polycystic kidney diseaseand medullary sponge kidney

The Bosniak classification categorizes renal cysts into five groupsCategory I

Benign simple cyst with thin wall without septa calcifications or solid

components

It does not enhance with contrast and has a density equal to that of water

Category IIBenign cyst with a few thin septa which may contain fine calcifications or a

small

segment of mildly thickened calcification This includes homogenous

high-attenuation lesions less than 3 cm with sharp margins(Rich Kosak) but

without enhancement

Category IIFWell marginated cysts with a number of thin septa with or without mild

enhancement or thickening of septa Calcifications may be present these

may be thick and nodular There are no enhancing soft tissue components

This also includes nonenhancing high-attenuation lesions that are completely

contained within the kidney and are 3 cm or larger

Category IIIIndeterminate cystic masses with thickened irregular septa with enhancement

Category IVMalignant cystic masses with all the characteristics of category III lesions

but also with enhancing soft tissue components independent of but adjacent

to the septa

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 11)

Classic findings of a simple cyst(Bosniak category 111)

Classic findings of a simple cyst(Bosniak category 1V)

Para-pelvic cyst USamp CT images

US of polycystic kidney disease

Renal infection

US of acute pyelonephritis

Acute bacterial pyelonephritis (a) US scan shows a wedge-shaped hyperechoic focus (arrowhead) in the upper pole of the right kidney related to acute bacterial pyelonephritis (b) Color flow US image demonstrates diminished flow through the involved area

US and color Doppler images of right kidney shows focal hyperechoic nephritis with decreased perfusion at the Doppler US

US and color Doppler images of kidney shows two multifocal nephritis with decreased perfusion at the Doppler US

Masslike appearance of acute bacterial pyelonephritis US and CT images

Emphysematous pyelonephritis (a) US image shows nondependent echoes within the left kidney that demonstrate a ring-down artifact (b) Corresponding CT scan helps confirm that this pattern is caused by intraparenchymal air

Xanthogranulomatous pyelonephritis (a) Contrast-enhanced CT scan demonstrates bilateral staghorn calculi with distention of the right collecting system secondary to inflammatory debris (b) US scan also shows the dilated

collecting system (arrowheads) and a shadowing calculus (arrow)

Early and mature abscess cavities (a) US scan demonstrates a geographic hypoechoic focus from an abscess in the upper pole of the right kidney (b) On a US scan of a more mature abscess the cavity is better defined with a visible pseudocapsule and through transmission that is evidenced by increased echogenicity deep to the upper pole lesion

Pyohydronephrosis

Pyohydronephrosis

Renal hydatidosis is an insidious disease and patients

often present with nonspecific clinical signs or symptoms Presenting complaints are dull flank pain hematuria palpable flank mass hypertension and renal colic

Disseminated abdominal retroperitoneal and pelvic hydatid disease (a) The right kidney is pushed to the midline and the left kidney is hydronephrotic and shrunken by retroperitoneal hydatid cysts (b) Ultrasound of the abdomen showing cystic lesions in the retroperitoneum in the position of the kidneys

Hydatid disease of the kidney US and CT images

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 7: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

EUS shows on left side an enlarged proximal shank

of adrenal gland which occurs in nodular hyperplasia

Adrenal Cyst A cyst of the adrenal region is anechoic has smooth margins and shows distal acoustic enhancement Its extent is variable True cysts have regular walls and are filled with serous material

Round sharply circumscribed echo-free mass located dorsal

to the right liver and cranial to the right kidney adrenal cyst

Intra-adrenal Hemorrhage (Hematoma) Bleeding into an adrenal gland is anechoic in its early

stage It can occur in newborns due to obstetric trauma

hypoxia or coagulation disorders Intra-adrenal

hemorrhage may correlate clinically with adrenal

insufficiency

A large central hemorrhage (adrenal apoplexy)

consistently leads to the marked enlargement of the gland

An older hemorrhage becomes increasingly echogenic

over time and may eventually be completely absorbed

Differentiation is required from partially cystic neuroblastomas in small children

Up to 25 of patients who sustain blunt abdominal trauma are discovered to have hematomas in the adrenal region They also occur in patients on anticoagulant medication and can lead to hypocortisolism (Addison disease)

Cystic anechoic mass in the left adrenal gland representing a hemorrhage

Echo -free intra-adrenal hemorrhage in a

newborn with high resolution ultrasound

Adrenal Abscess An abscess of the adrenal glands is rarely anechoic It is usually hypoechoic

or has a complex echo structure When the contents are anechoic the clinical

and laboratory findings can differentiate the lesion from an ordinary cyst The

wall is irregular and distal acoustic enhancement may be present

Transverse ultrasound image reveals anechoic cystic masses containing internal echoes and debris at bilateral supra renal area and right is measuring more than left

Longitudinal ultrasound image reveals anechoic cystic abscess With wall calcification and needle in the lesion during procedure

Benign adrenal gland tumours Adenoma Adenomas are uniformly hypoechoic with smooth margins and a round to oval shape although some lesions have scalloped borders (polycyclic) Adenomas occasionally have an inhomogeneous appearance Autopsy statistics indicate that they are quite common (10ndash20) but most adenomas (90) produce no endocrine symptoms they are bdquosilentldquo and too small to be seen with ultrasound The average size of adenomas in one study was 15 cm although they may exceed 5 cm in diameter In a small percentage of patients adenomas are bilateral Functioning and nonfunctioning adenomas are indistinguishable by their sonographic features

Medial to the upper pole of the right kidney is a sharply circumscribed hypoechoic mass typical adrenal adenoma

Hypoechoic sharply circumscribed adenoma of the right adrenal gland discovered

at routine ultrasound (confirmed by ultrasound-guided fine-needle aspiration)

Approximately 5 cm hypoechoic inhomogenous mass above the right kidney adenoma (incidentaloma) without associated symptoms detected at routine upper abdominal ultrasound Histology identified as an adrenal adenoma (most common incidentaloma)

Lipoma Myelolipoma

Lipoma A pure lipoma of the adrenal glands has

smooth margins and high homogeneous

echogenicity In contrast to the mixed tissues of

myolipoma posterior acoustic shadowing does

not occur Lipoma is rare and shows no proliferative tendency

Myelolipoma Adrenal myelolipoma has smooth margins and a homogeneous hyperechoic structure It resembles a renal angiomyolipoma in its sonographic features Posterior acoustic shadowing is often present Malignant transformation is not known to occur The tumour consists histologically of fat and bone marrow tissue (hematopoietic cells and reticular cells) Intratumoral hemorrhage and calcifications may be seen

Homogeneous sharply circumscribed hyperechoic tumour adjacent to the right kidney Classic adrenal myelolipoma

In CEUS a myelolipoma shows a nearly constant

contrast enhancement without wash out

Calcification Complete or partial calcification of the adrenal glands is characterized by a

typical echo complex with a posterior acoustic shadow Calcifications can

result from a retained intra-adrenal hemorrhage or a prior inflammatory

process (eg tuberculosis) Patients occasionally show the clinical

manifestations of Addison disease However calcifications can also develop in

tumours (carcinoma metastases Pheochromocytoma adenoma)

In the proximal left kidney in the adrenal gland region wefound a classical calcification with dorsal acoustic shadow

Small calcifications also occur in tumours of adrenal gland most often observed in pheochromocytoma

Malignant adrenal gland tumours Metastases With their rich blood supply the adrenal glands are the fourth

most frequent site for hematogenous metastasis Metastases

to the adrenal glands account for the majority of solid adrenal

tumours after the adenomas

In contrast to adenomas these lesions are less homogeneous

and often have irregular margins The most common

primaries are bronchial carcinoma (25ndash30 ) breast

carcinoma and malignant melanoma Other possible sources

are gastrointestinal urological and gynecological tumours

(renal carcinoma gastric carcinoma pancreatic carcinoma

and others) Adrenal metastases are bilateral in up to 30 of

cases and this can produce the clinical manifestations of

Addison disease Bronchial carcinoma is virtually the only

tumour that is associated with isolated adrenal metastases

(in ca 15-20 )

Large metastasis from bronchial carcinoma on the right

side with a very inhomogeneous internal structure Solid

components are seen along with central liquid areas

Transverse scan shows a metastasis with a complex echo structure ldquowedgedrdquo between right lobe of the liver inferior vena cava the kidney and spinal column

Transverse scan of a metastasis of the right adrenal gland with complex structure beside a primary tumour of lung cancer

Partial metastases esp of lung cancer show

a wash out of contrast media in late phase

US examination longitudinal view Above the right kidney in the adrenal region a solid slightly inhomogeneous mass can be seen Neuroblastoma MRI examination

axial T2 weighted image Irregular large solid inhomogeneous retroperitoneal tumor

Pheochromocytoma Pheochromocytoma is a tumour of the adrenal medulla that is generally

detected sonographically (80ndash90 of cases) following the appearance

of clinical symptoms (hypertension and tachycardia caused by

increased catecholamine secretion)

Most pheochromocytomas are already several centimeters in diameter

when diagnosed They have smooth margins a round shape and a

nonhomogeneous or complex echo structure

Hypoechoic liquid components are also observed A spectrum of

appearances may be seen Pheochromocytomas are bilateral in

approximately 10 of cases and extra-adrenal in 10ndash20

The ldquoZuckerkandl organrdquo should be looked for at the level of the origin

of the inferior mesenteric artery anterior to the aorta

Other extra-adrenal sites are the renal hilum bladder wall and thorax

Pheochromocytoma is occasionally seen posterior to the renal vein in

transverse scans Rarely pheochromocytoma is diagnosed in the

setting of multiple endocrine neoplasia (MEN) From 2 to 5 of

pheochromocytomas are malignant Owing to the risk of inciting a

hypertensive crisis fine-needle aspiration biopsy causes discrepant

discussions about FNB

Nonhomogeneous tumour with a hyperechoic center (positive endocrine test increased catecholamine secretion) ndash Pheochromocytoma

Large functionally active pheochromocytoma (7 cm in diameter) The scan shows that most of tumour is hypoechoic with some hyperechoic regions

Lymphoma The adrenal region is a rare extranodal site of occurrence for lymphoma

Foci of lymphomatous infiltration have smooth borders and are

hypoechoic Differentiation is required from lymphomas in the renal or

splenic hilum If invasion by lymphoma is suspected other nodal

stations should be scanned and commonly infiltrated organs (spleen

liver) should be closely scrutinized

Perisplenic lymphoma in the left adrenal region of a patient with B-cell lymphoma

Colour Doppler shows hypervascularisation of the lymphatic tissue

Adrenal Carcinoma Adrenal carcinoma is usually inhomogeneous hypoechoic or echo complex with irregular margins It frequently infiltrates its surroundings and metastases can be demonstrated in the adrenal region and in other organs (eg the liver) The adrenal carcinoma is a very rare (1 17 million inhabitants) highly malignant tumour with a poor prognosis Adrenal carcinoma is indistinguishable sonographically from a metastasis although the visualization of additional tumours can advance the differential diagnosis Most adrenal carcinomas are hormone-producing Sometimes one can get evidence from detection of other tumour sign The tumour is usually detected only after it has reached considerable size (often gt8 cm) Intratumoral hemorrhage necrotic foci and calcifications may occur adding to the variegated appearance

Adrenal carcinoma may be hypoechoic or may have a complex echo structure Usually it

was relatively large when diagnosed (in this case 8 cm times 9 cm) and had irregular margins

Right adrenal adenocarcinoma A Sonogram showing a complex mass with cystic changes in the right adrenal gland (arrows) B Computed tomogram showing the mass (arrows)

Incidentaloma An incidentaloma is an adrenal tumour that is detected incidentally in an asymptomatic patient Incidentalomas are found in 1 of CT examinations They are much less common in ultrasound examinations because of the difficulty in defining small lesions (lt 2 cm) The predominantly hypoechoic tumours account for the great majority of incidentalomas shows the algorithm used in the investigation of incidentalomas Approximately 10 to 15 of these tumours are hormonally active In some cases ultrasound-guided fine-needle aspiration can also aid in the evaluation of incidentalomas but only ca 1 to 2 of these tumours are malignant

Abdominal ultrasound examination incidentally found most hypoechoic lesions

smaller 2 cm without clinical symptoms ndash which is typical for incidentalomas

Histoplasmosis is a geographically restricted form of

fungal infection Adrenal involvement is seen in disseminated disease but sometimes it may be the only site of demonstrable disease Early diagnosis and treatment may save the patient from catastrophic adrenal insufficiency We present two patients showing bilateral adrenomegaly on ultrasonography and contrast-enhanced CT and was diagnosed to have histoplasmosis on fine-needle aspiration cytology

Histoplasmosis is an infective condition caused by a

dimorphic saprophytic fungus Histoplasma capsulatum and is acquired by inhalation of its spores Soil rich in bird and bat dropping is its natural habitat and it exists as a mycelium in the atmosphere

Both adrenal gland were enlarged and hypoechoic at US study

US show bilateral hypoechoic lesions and CT showed peripherally enhancing hypodense bilateral adrenals with peripheral rim and septate enhancement

ULTRASOUND OF THE ADULT KIDNEY ndash Normal

Coronal scan plane for the Right Kidney Longitudinal Normal Kidney

Scan plane transverse kidney Transverse normal image

Common anatomical variantsAtrophic small kidneyHorseshoe kidneyEctopic kidneyDuplex kidneyCross fused ectopiaUnilateral renal agenesis

COMMON PATHOLOGYCalculusRenal cyst Cortical and Para-pelvicAngiomyolipmaRenal infectionRenal cell carcinomaTransitional cell carcinomaMedullary sponge kidneyPolycystic kidney disease

Horseshoe kidney A transverse and longitudinal view across the midline showing the isthmus across the aorta

Cross fused ectopic kidney The left kidney is fused to the lower pole of the right kidney

A baggy extra-renal pelvis

Pelvic ectopic kidney

UltrasonographyOn sonograms stones are demonstrated as bright echogenic foci with posterior acoustic shadowing Stones are visualized fairly well with US in the kidneys and the distal ureter at or near the UVJ especially if dilatation is present US is good for the visualization of complications such as hydronephrosis (or other signs of obstruction) however some patients with acute obstruction have little or no dilationIn particular US is helpful in evaluating those with renal insufficiency or contraindications for the use of contrast media however US is often skipped in favor of nonenhanced CTIn addition US is good for characterizing lucent filling defects that are visualized as stones on IVU However US does not provide direct physiologic information regarding the degree of obstruction Doppler imaging may demonstrate a high resistive index in acute obstruction but this may not occur immediately or after forniceal rupture Absence of the ureteral jet as visualized with color Doppler on the symptomatic side is presumptive evidence for a high-grade obstruction in a well-hydrated patient

Degree of confidenceUS is very insensitive for stones especially stones smaller than 2 mm stones at the UPJ or stones in the mid ureter Fowler et al suggest that US has a sensitivity as low as 24 compared with nonenhanced CT Furthermore estimations of stone size may not be accurate Compared with nonenhanced CT US is more dependent on the operators ability and more time consuming

False positivesnegativesUS is fairly specific when stones are seen with a specificity as high as 90 With US matrix or indinavir stones may have soft tissue echogenicity without shadowing False-positive findings may result from renal vascular calcifications False-positive diagnoses of hydronephrosis also result from dilated vascular structures in the renal hilum Doppler imaging is helpful in distinguishing dilated vascular structures from hydronephrosis

Renal sonogram demonstrates an echogenic shadowing calculus in the renal collecting system with hydronephrosis

US images for renal stones

US images of staghorn stones

US images for ureteric stones

US images for nephrocalcinosis

Renal cystA renal cyst is a fluid collection in the kidney There are several types based on the Bosniak classification The majority are benign simple cysts that can be monitored and not intervened upon However some are cancerous or are suspicious for cancer and are commonly removed in a surgical procedure called nephrectomyNumerous renal cysts are seen in the cystic kidney diseases which include polycystic kidney diseaseand medullary sponge kidney

The Bosniak classification categorizes renal cysts into five groupsCategory I

Benign simple cyst with thin wall without septa calcifications or solid

components

It does not enhance with contrast and has a density equal to that of water

Category IIBenign cyst with a few thin septa which may contain fine calcifications or a

small

segment of mildly thickened calcification This includes homogenous

high-attenuation lesions less than 3 cm with sharp margins(Rich Kosak) but

without enhancement

Category IIFWell marginated cysts with a number of thin septa with or without mild

enhancement or thickening of septa Calcifications may be present these

may be thick and nodular There are no enhancing soft tissue components

This also includes nonenhancing high-attenuation lesions that are completely

contained within the kidney and are 3 cm or larger

Category IIIIndeterminate cystic masses with thickened irregular septa with enhancement

Category IVMalignant cystic masses with all the characteristics of category III lesions

but also with enhancing soft tissue components independent of but adjacent

to the septa

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 11)

Classic findings of a simple cyst(Bosniak category 111)

Classic findings of a simple cyst(Bosniak category 1V)

Para-pelvic cyst USamp CT images

US of polycystic kidney disease

Renal infection

US of acute pyelonephritis

Acute bacterial pyelonephritis (a) US scan shows a wedge-shaped hyperechoic focus (arrowhead) in the upper pole of the right kidney related to acute bacterial pyelonephritis (b) Color flow US image demonstrates diminished flow through the involved area

US and color Doppler images of right kidney shows focal hyperechoic nephritis with decreased perfusion at the Doppler US

US and color Doppler images of kidney shows two multifocal nephritis with decreased perfusion at the Doppler US

Masslike appearance of acute bacterial pyelonephritis US and CT images

Emphysematous pyelonephritis (a) US image shows nondependent echoes within the left kidney that demonstrate a ring-down artifact (b) Corresponding CT scan helps confirm that this pattern is caused by intraparenchymal air

Xanthogranulomatous pyelonephritis (a) Contrast-enhanced CT scan demonstrates bilateral staghorn calculi with distention of the right collecting system secondary to inflammatory debris (b) US scan also shows the dilated

collecting system (arrowheads) and a shadowing calculus (arrow)

Early and mature abscess cavities (a) US scan demonstrates a geographic hypoechoic focus from an abscess in the upper pole of the right kidney (b) On a US scan of a more mature abscess the cavity is better defined with a visible pseudocapsule and through transmission that is evidenced by increased echogenicity deep to the upper pole lesion

Pyohydronephrosis

Pyohydronephrosis

Renal hydatidosis is an insidious disease and patients

often present with nonspecific clinical signs or symptoms Presenting complaints are dull flank pain hematuria palpable flank mass hypertension and renal colic

Disseminated abdominal retroperitoneal and pelvic hydatid disease (a) The right kidney is pushed to the midline and the left kidney is hydronephrotic and shrunken by retroperitoneal hydatid cysts (b) Ultrasound of the abdomen showing cystic lesions in the retroperitoneum in the position of the kidneys

Hydatid disease of the kidney US and CT images

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 8: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Adrenal Cyst A cyst of the adrenal region is anechoic has smooth margins and shows distal acoustic enhancement Its extent is variable True cysts have regular walls and are filled with serous material

Round sharply circumscribed echo-free mass located dorsal

to the right liver and cranial to the right kidney adrenal cyst

Intra-adrenal Hemorrhage (Hematoma) Bleeding into an adrenal gland is anechoic in its early

stage It can occur in newborns due to obstetric trauma

hypoxia or coagulation disorders Intra-adrenal

hemorrhage may correlate clinically with adrenal

insufficiency

A large central hemorrhage (adrenal apoplexy)

consistently leads to the marked enlargement of the gland

An older hemorrhage becomes increasingly echogenic

over time and may eventually be completely absorbed

Differentiation is required from partially cystic neuroblastomas in small children

Up to 25 of patients who sustain blunt abdominal trauma are discovered to have hematomas in the adrenal region They also occur in patients on anticoagulant medication and can lead to hypocortisolism (Addison disease)

Cystic anechoic mass in the left adrenal gland representing a hemorrhage

Echo -free intra-adrenal hemorrhage in a

newborn with high resolution ultrasound

Adrenal Abscess An abscess of the adrenal glands is rarely anechoic It is usually hypoechoic

or has a complex echo structure When the contents are anechoic the clinical

and laboratory findings can differentiate the lesion from an ordinary cyst The

wall is irregular and distal acoustic enhancement may be present

Transverse ultrasound image reveals anechoic cystic masses containing internal echoes and debris at bilateral supra renal area and right is measuring more than left

Longitudinal ultrasound image reveals anechoic cystic abscess With wall calcification and needle in the lesion during procedure

Benign adrenal gland tumours Adenoma Adenomas are uniformly hypoechoic with smooth margins and a round to oval shape although some lesions have scalloped borders (polycyclic) Adenomas occasionally have an inhomogeneous appearance Autopsy statistics indicate that they are quite common (10ndash20) but most adenomas (90) produce no endocrine symptoms they are bdquosilentldquo and too small to be seen with ultrasound The average size of adenomas in one study was 15 cm although they may exceed 5 cm in diameter In a small percentage of patients adenomas are bilateral Functioning and nonfunctioning adenomas are indistinguishable by their sonographic features

Medial to the upper pole of the right kidney is a sharply circumscribed hypoechoic mass typical adrenal adenoma

Hypoechoic sharply circumscribed adenoma of the right adrenal gland discovered

at routine ultrasound (confirmed by ultrasound-guided fine-needle aspiration)

Approximately 5 cm hypoechoic inhomogenous mass above the right kidney adenoma (incidentaloma) without associated symptoms detected at routine upper abdominal ultrasound Histology identified as an adrenal adenoma (most common incidentaloma)

Lipoma Myelolipoma

Lipoma A pure lipoma of the adrenal glands has

smooth margins and high homogeneous

echogenicity In contrast to the mixed tissues of

myolipoma posterior acoustic shadowing does

not occur Lipoma is rare and shows no proliferative tendency

Myelolipoma Adrenal myelolipoma has smooth margins and a homogeneous hyperechoic structure It resembles a renal angiomyolipoma in its sonographic features Posterior acoustic shadowing is often present Malignant transformation is not known to occur The tumour consists histologically of fat and bone marrow tissue (hematopoietic cells and reticular cells) Intratumoral hemorrhage and calcifications may be seen

Homogeneous sharply circumscribed hyperechoic tumour adjacent to the right kidney Classic adrenal myelolipoma

In CEUS a myelolipoma shows a nearly constant

contrast enhancement without wash out

Calcification Complete or partial calcification of the adrenal glands is characterized by a

typical echo complex with a posterior acoustic shadow Calcifications can

result from a retained intra-adrenal hemorrhage or a prior inflammatory

process (eg tuberculosis) Patients occasionally show the clinical

manifestations of Addison disease However calcifications can also develop in

tumours (carcinoma metastases Pheochromocytoma adenoma)

In the proximal left kidney in the adrenal gland region wefound a classical calcification with dorsal acoustic shadow

Small calcifications also occur in tumours of adrenal gland most often observed in pheochromocytoma

Malignant adrenal gland tumours Metastases With their rich blood supply the adrenal glands are the fourth

most frequent site for hematogenous metastasis Metastases

to the adrenal glands account for the majority of solid adrenal

tumours after the adenomas

In contrast to adenomas these lesions are less homogeneous

and often have irregular margins The most common

primaries are bronchial carcinoma (25ndash30 ) breast

carcinoma and malignant melanoma Other possible sources

are gastrointestinal urological and gynecological tumours

(renal carcinoma gastric carcinoma pancreatic carcinoma

and others) Adrenal metastases are bilateral in up to 30 of

cases and this can produce the clinical manifestations of

Addison disease Bronchial carcinoma is virtually the only

tumour that is associated with isolated adrenal metastases

(in ca 15-20 )

Large metastasis from bronchial carcinoma on the right

side with a very inhomogeneous internal structure Solid

components are seen along with central liquid areas

Transverse scan shows a metastasis with a complex echo structure ldquowedgedrdquo between right lobe of the liver inferior vena cava the kidney and spinal column

Transverse scan of a metastasis of the right adrenal gland with complex structure beside a primary tumour of lung cancer

Partial metastases esp of lung cancer show

a wash out of contrast media in late phase

US examination longitudinal view Above the right kidney in the adrenal region a solid slightly inhomogeneous mass can be seen Neuroblastoma MRI examination

axial T2 weighted image Irregular large solid inhomogeneous retroperitoneal tumor

Pheochromocytoma Pheochromocytoma is a tumour of the adrenal medulla that is generally

detected sonographically (80ndash90 of cases) following the appearance

of clinical symptoms (hypertension and tachycardia caused by

increased catecholamine secretion)

Most pheochromocytomas are already several centimeters in diameter

when diagnosed They have smooth margins a round shape and a

nonhomogeneous or complex echo structure

Hypoechoic liquid components are also observed A spectrum of

appearances may be seen Pheochromocytomas are bilateral in

approximately 10 of cases and extra-adrenal in 10ndash20

The ldquoZuckerkandl organrdquo should be looked for at the level of the origin

of the inferior mesenteric artery anterior to the aorta

Other extra-adrenal sites are the renal hilum bladder wall and thorax

Pheochromocytoma is occasionally seen posterior to the renal vein in

transverse scans Rarely pheochromocytoma is diagnosed in the

setting of multiple endocrine neoplasia (MEN) From 2 to 5 of

pheochromocytomas are malignant Owing to the risk of inciting a

hypertensive crisis fine-needle aspiration biopsy causes discrepant

discussions about FNB

Nonhomogeneous tumour with a hyperechoic center (positive endocrine test increased catecholamine secretion) ndash Pheochromocytoma

Large functionally active pheochromocytoma (7 cm in diameter) The scan shows that most of tumour is hypoechoic with some hyperechoic regions

Lymphoma The adrenal region is a rare extranodal site of occurrence for lymphoma

Foci of lymphomatous infiltration have smooth borders and are

hypoechoic Differentiation is required from lymphomas in the renal or

splenic hilum If invasion by lymphoma is suspected other nodal

stations should be scanned and commonly infiltrated organs (spleen

liver) should be closely scrutinized

Perisplenic lymphoma in the left adrenal region of a patient with B-cell lymphoma

Colour Doppler shows hypervascularisation of the lymphatic tissue

Adrenal Carcinoma Adrenal carcinoma is usually inhomogeneous hypoechoic or echo complex with irregular margins It frequently infiltrates its surroundings and metastases can be demonstrated in the adrenal region and in other organs (eg the liver) The adrenal carcinoma is a very rare (1 17 million inhabitants) highly malignant tumour with a poor prognosis Adrenal carcinoma is indistinguishable sonographically from a metastasis although the visualization of additional tumours can advance the differential diagnosis Most adrenal carcinomas are hormone-producing Sometimes one can get evidence from detection of other tumour sign The tumour is usually detected only after it has reached considerable size (often gt8 cm) Intratumoral hemorrhage necrotic foci and calcifications may occur adding to the variegated appearance

Adrenal carcinoma may be hypoechoic or may have a complex echo structure Usually it

was relatively large when diagnosed (in this case 8 cm times 9 cm) and had irregular margins

Right adrenal adenocarcinoma A Sonogram showing a complex mass with cystic changes in the right adrenal gland (arrows) B Computed tomogram showing the mass (arrows)

Incidentaloma An incidentaloma is an adrenal tumour that is detected incidentally in an asymptomatic patient Incidentalomas are found in 1 of CT examinations They are much less common in ultrasound examinations because of the difficulty in defining small lesions (lt 2 cm) The predominantly hypoechoic tumours account for the great majority of incidentalomas shows the algorithm used in the investigation of incidentalomas Approximately 10 to 15 of these tumours are hormonally active In some cases ultrasound-guided fine-needle aspiration can also aid in the evaluation of incidentalomas but only ca 1 to 2 of these tumours are malignant

Abdominal ultrasound examination incidentally found most hypoechoic lesions

smaller 2 cm without clinical symptoms ndash which is typical for incidentalomas

Histoplasmosis is a geographically restricted form of

fungal infection Adrenal involvement is seen in disseminated disease but sometimes it may be the only site of demonstrable disease Early diagnosis and treatment may save the patient from catastrophic adrenal insufficiency We present two patients showing bilateral adrenomegaly on ultrasonography and contrast-enhanced CT and was diagnosed to have histoplasmosis on fine-needle aspiration cytology

Histoplasmosis is an infective condition caused by a

dimorphic saprophytic fungus Histoplasma capsulatum and is acquired by inhalation of its spores Soil rich in bird and bat dropping is its natural habitat and it exists as a mycelium in the atmosphere

Both adrenal gland were enlarged and hypoechoic at US study

US show bilateral hypoechoic lesions and CT showed peripherally enhancing hypodense bilateral adrenals with peripheral rim and septate enhancement

ULTRASOUND OF THE ADULT KIDNEY ndash Normal

Coronal scan plane for the Right Kidney Longitudinal Normal Kidney

Scan plane transverse kidney Transverse normal image

Common anatomical variantsAtrophic small kidneyHorseshoe kidneyEctopic kidneyDuplex kidneyCross fused ectopiaUnilateral renal agenesis

COMMON PATHOLOGYCalculusRenal cyst Cortical and Para-pelvicAngiomyolipmaRenal infectionRenal cell carcinomaTransitional cell carcinomaMedullary sponge kidneyPolycystic kidney disease

Horseshoe kidney A transverse and longitudinal view across the midline showing the isthmus across the aorta

Cross fused ectopic kidney The left kidney is fused to the lower pole of the right kidney

A baggy extra-renal pelvis

Pelvic ectopic kidney

UltrasonographyOn sonograms stones are demonstrated as bright echogenic foci with posterior acoustic shadowing Stones are visualized fairly well with US in the kidneys and the distal ureter at or near the UVJ especially if dilatation is present US is good for the visualization of complications such as hydronephrosis (or other signs of obstruction) however some patients with acute obstruction have little or no dilationIn particular US is helpful in evaluating those with renal insufficiency or contraindications for the use of contrast media however US is often skipped in favor of nonenhanced CTIn addition US is good for characterizing lucent filling defects that are visualized as stones on IVU However US does not provide direct physiologic information regarding the degree of obstruction Doppler imaging may demonstrate a high resistive index in acute obstruction but this may not occur immediately or after forniceal rupture Absence of the ureteral jet as visualized with color Doppler on the symptomatic side is presumptive evidence for a high-grade obstruction in a well-hydrated patient

Degree of confidenceUS is very insensitive for stones especially stones smaller than 2 mm stones at the UPJ or stones in the mid ureter Fowler et al suggest that US has a sensitivity as low as 24 compared with nonenhanced CT Furthermore estimations of stone size may not be accurate Compared with nonenhanced CT US is more dependent on the operators ability and more time consuming

False positivesnegativesUS is fairly specific when stones are seen with a specificity as high as 90 With US matrix or indinavir stones may have soft tissue echogenicity without shadowing False-positive findings may result from renal vascular calcifications False-positive diagnoses of hydronephrosis also result from dilated vascular structures in the renal hilum Doppler imaging is helpful in distinguishing dilated vascular structures from hydronephrosis

Renal sonogram demonstrates an echogenic shadowing calculus in the renal collecting system with hydronephrosis

US images for renal stones

US images of staghorn stones

US images for ureteric stones

US images for nephrocalcinosis

Renal cystA renal cyst is a fluid collection in the kidney There are several types based on the Bosniak classification The majority are benign simple cysts that can be monitored and not intervened upon However some are cancerous or are suspicious for cancer and are commonly removed in a surgical procedure called nephrectomyNumerous renal cysts are seen in the cystic kidney diseases which include polycystic kidney diseaseand medullary sponge kidney

The Bosniak classification categorizes renal cysts into five groupsCategory I

Benign simple cyst with thin wall without septa calcifications or solid

components

It does not enhance with contrast and has a density equal to that of water

Category IIBenign cyst with a few thin septa which may contain fine calcifications or a

small

segment of mildly thickened calcification This includes homogenous

high-attenuation lesions less than 3 cm with sharp margins(Rich Kosak) but

without enhancement

Category IIFWell marginated cysts with a number of thin septa with or without mild

enhancement or thickening of septa Calcifications may be present these

may be thick and nodular There are no enhancing soft tissue components

This also includes nonenhancing high-attenuation lesions that are completely

contained within the kidney and are 3 cm or larger

Category IIIIndeterminate cystic masses with thickened irregular septa with enhancement

Category IVMalignant cystic masses with all the characteristics of category III lesions

but also with enhancing soft tissue components independent of but adjacent

to the septa

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 11)

Classic findings of a simple cyst(Bosniak category 111)

Classic findings of a simple cyst(Bosniak category 1V)

Para-pelvic cyst USamp CT images

US of polycystic kidney disease

Renal infection

US of acute pyelonephritis

Acute bacterial pyelonephritis (a) US scan shows a wedge-shaped hyperechoic focus (arrowhead) in the upper pole of the right kidney related to acute bacterial pyelonephritis (b) Color flow US image demonstrates diminished flow through the involved area

US and color Doppler images of right kidney shows focal hyperechoic nephritis with decreased perfusion at the Doppler US

US and color Doppler images of kidney shows two multifocal nephritis with decreased perfusion at the Doppler US

Masslike appearance of acute bacterial pyelonephritis US and CT images

Emphysematous pyelonephritis (a) US image shows nondependent echoes within the left kidney that demonstrate a ring-down artifact (b) Corresponding CT scan helps confirm that this pattern is caused by intraparenchymal air

Xanthogranulomatous pyelonephritis (a) Contrast-enhanced CT scan demonstrates bilateral staghorn calculi with distention of the right collecting system secondary to inflammatory debris (b) US scan also shows the dilated

collecting system (arrowheads) and a shadowing calculus (arrow)

Early and mature abscess cavities (a) US scan demonstrates a geographic hypoechoic focus from an abscess in the upper pole of the right kidney (b) On a US scan of a more mature abscess the cavity is better defined with a visible pseudocapsule and through transmission that is evidenced by increased echogenicity deep to the upper pole lesion

Pyohydronephrosis

Pyohydronephrosis

Renal hydatidosis is an insidious disease and patients

often present with nonspecific clinical signs or symptoms Presenting complaints are dull flank pain hematuria palpable flank mass hypertension and renal colic

Disseminated abdominal retroperitoneal and pelvic hydatid disease (a) The right kidney is pushed to the midline and the left kidney is hydronephrotic and shrunken by retroperitoneal hydatid cysts (b) Ultrasound of the abdomen showing cystic lesions in the retroperitoneum in the position of the kidneys

Hydatid disease of the kidney US and CT images

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 9: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Intra-adrenal Hemorrhage (Hematoma) Bleeding into an adrenal gland is anechoic in its early

stage It can occur in newborns due to obstetric trauma

hypoxia or coagulation disorders Intra-adrenal

hemorrhage may correlate clinically with adrenal

insufficiency

A large central hemorrhage (adrenal apoplexy)

consistently leads to the marked enlargement of the gland

An older hemorrhage becomes increasingly echogenic

over time and may eventually be completely absorbed

Differentiation is required from partially cystic neuroblastomas in small children

Up to 25 of patients who sustain blunt abdominal trauma are discovered to have hematomas in the adrenal region They also occur in patients on anticoagulant medication and can lead to hypocortisolism (Addison disease)

Cystic anechoic mass in the left adrenal gland representing a hemorrhage

Echo -free intra-adrenal hemorrhage in a

newborn with high resolution ultrasound

Adrenal Abscess An abscess of the adrenal glands is rarely anechoic It is usually hypoechoic

or has a complex echo structure When the contents are anechoic the clinical

and laboratory findings can differentiate the lesion from an ordinary cyst The

wall is irregular and distal acoustic enhancement may be present

Transverse ultrasound image reveals anechoic cystic masses containing internal echoes and debris at bilateral supra renal area and right is measuring more than left

Longitudinal ultrasound image reveals anechoic cystic abscess With wall calcification and needle in the lesion during procedure

Benign adrenal gland tumours Adenoma Adenomas are uniformly hypoechoic with smooth margins and a round to oval shape although some lesions have scalloped borders (polycyclic) Adenomas occasionally have an inhomogeneous appearance Autopsy statistics indicate that they are quite common (10ndash20) but most adenomas (90) produce no endocrine symptoms they are bdquosilentldquo and too small to be seen with ultrasound The average size of adenomas in one study was 15 cm although they may exceed 5 cm in diameter In a small percentage of patients adenomas are bilateral Functioning and nonfunctioning adenomas are indistinguishable by their sonographic features

Medial to the upper pole of the right kidney is a sharply circumscribed hypoechoic mass typical adrenal adenoma

Hypoechoic sharply circumscribed adenoma of the right adrenal gland discovered

at routine ultrasound (confirmed by ultrasound-guided fine-needle aspiration)

Approximately 5 cm hypoechoic inhomogenous mass above the right kidney adenoma (incidentaloma) without associated symptoms detected at routine upper abdominal ultrasound Histology identified as an adrenal adenoma (most common incidentaloma)

Lipoma Myelolipoma

Lipoma A pure lipoma of the adrenal glands has

smooth margins and high homogeneous

echogenicity In contrast to the mixed tissues of

myolipoma posterior acoustic shadowing does

not occur Lipoma is rare and shows no proliferative tendency

Myelolipoma Adrenal myelolipoma has smooth margins and a homogeneous hyperechoic structure It resembles a renal angiomyolipoma in its sonographic features Posterior acoustic shadowing is often present Malignant transformation is not known to occur The tumour consists histologically of fat and bone marrow tissue (hematopoietic cells and reticular cells) Intratumoral hemorrhage and calcifications may be seen

Homogeneous sharply circumscribed hyperechoic tumour adjacent to the right kidney Classic adrenal myelolipoma

In CEUS a myelolipoma shows a nearly constant

contrast enhancement without wash out

Calcification Complete or partial calcification of the adrenal glands is characterized by a

typical echo complex with a posterior acoustic shadow Calcifications can

result from a retained intra-adrenal hemorrhage or a prior inflammatory

process (eg tuberculosis) Patients occasionally show the clinical

manifestations of Addison disease However calcifications can also develop in

tumours (carcinoma metastases Pheochromocytoma adenoma)

In the proximal left kidney in the adrenal gland region wefound a classical calcification with dorsal acoustic shadow

Small calcifications also occur in tumours of adrenal gland most often observed in pheochromocytoma

Malignant adrenal gland tumours Metastases With their rich blood supply the adrenal glands are the fourth

most frequent site for hematogenous metastasis Metastases

to the adrenal glands account for the majority of solid adrenal

tumours after the adenomas

In contrast to adenomas these lesions are less homogeneous

and often have irregular margins The most common

primaries are bronchial carcinoma (25ndash30 ) breast

carcinoma and malignant melanoma Other possible sources

are gastrointestinal urological and gynecological tumours

(renal carcinoma gastric carcinoma pancreatic carcinoma

and others) Adrenal metastases are bilateral in up to 30 of

cases and this can produce the clinical manifestations of

Addison disease Bronchial carcinoma is virtually the only

tumour that is associated with isolated adrenal metastases

(in ca 15-20 )

Large metastasis from bronchial carcinoma on the right

side with a very inhomogeneous internal structure Solid

components are seen along with central liquid areas

Transverse scan shows a metastasis with a complex echo structure ldquowedgedrdquo between right lobe of the liver inferior vena cava the kidney and spinal column

Transverse scan of a metastasis of the right adrenal gland with complex structure beside a primary tumour of lung cancer

Partial metastases esp of lung cancer show

a wash out of contrast media in late phase

US examination longitudinal view Above the right kidney in the adrenal region a solid slightly inhomogeneous mass can be seen Neuroblastoma MRI examination

axial T2 weighted image Irregular large solid inhomogeneous retroperitoneal tumor

Pheochromocytoma Pheochromocytoma is a tumour of the adrenal medulla that is generally

detected sonographically (80ndash90 of cases) following the appearance

of clinical symptoms (hypertension and tachycardia caused by

increased catecholamine secretion)

Most pheochromocytomas are already several centimeters in diameter

when diagnosed They have smooth margins a round shape and a

nonhomogeneous or complex echo structure

Hypoechoic liquid components are also observed A spectrum of

appearances may be seen Pheochromocytomas are bilateral in

approximately 10 of cases and extra-adrenal in 10ndash20

The ldquoZuckerkandl organrdquo should be looked for at the level of the origin

of the inferior mesenteric artery anterior to the aorta

Other extra-adrenal sites are the renal hilum bladder wall and thorax

Pheochromocytoma is occasionally seen posterior to the renal vein in

transverse scans Rarely pheochromocytoma is diagnosed in the

setting of multiple endocrine neoplasia (MEN) From 2 to 5 of

pheochromocytomas are malignant Owing to the risk of inciting a

hypertensive crisis fine-needle aspiration biopsy causes discrepant

discussions about FNB

Nonhomogeneous tumour with a hyperechoic center (positive endocrine test increased catecholamine secretion) ndash Pheochromocytoma

Large functionally active pheochromocytoma (7 cm in diameter) The scan shows that most of tumour is hypoechoic with some hyperechoic regions

Lymphoma The adrenal region is a rare extranodal site of occurrence for lymphoma

Foci of lymphomatous infiltration have smooth borders and are

hypoechoic Differentiation is required from lymphomas in the renal or

splenic hilum If invasion by lymphoma is suspected other nodal

stations should be scanned and commonly infiltrated organs (spleen

liver) should be closely scrutinized

Perisplenic lymphoma in the left adrenal region of a patient with B-cell lymphoma

Colour Doppler shows hypervascularisation of the lymphatic tissue

Adrenal Carcinoma Adrenal carcinoma is usually inhomogeneous hypoechoic or echo complex with irregular margins It frequently infiltrates its surroundings and metastases can be demonstrated in the adrenal region and in other organs (eg the liver) The adrenal carcinoma is a very rare (1 17 million inhabitants) highly malignant tumour with a poor prognosis Adrenal carcinoma is indistinguishable sonographically from a metastasis although the visualization of additional tumours can advance the differential diagnosis Most adrenal carcinomas are hormone-producing Sometimes one can get evidence from detection of other tumour sign The tumour is usually detected only after it has reached considerable size (often gt8 cm) Intratumoral hemorrhage necrotic foci and calcifications may occur adding to the variegated appearance

Adrenal carcinoma may be hypoechoic or may have a complex echo structure Usually it

was relatively large when diagnosed (in this case 8 cm times 9 cm) and had irregular margins

Right adrenal adenocarcinoma A Sonogram showing a complex mass with cystic changes in the right adrenal gland (arrows) B Computed tomogram showing the mass (arrows)

Incidentaloma An incidentaloma is an adrenal tumour that is detected incidentally in an asymptomatic patient Incidentalomas are found in 1 of CT examinations They are much less common in ultrasound examinations because of the difficulty in defining small lesions (lt 2 cm) The predominantly hypoechoic tumours account for the great majority of incidentalomas shows the algorithm used in the investigation of incidentalomas Approximately 10 to 15 of these tumours are hormonally active In some cases ultrasound-guided fine-needle aspiration can also aid in the evaluation of incidentalomas but only ca 1 to 2 of these tumours are malignant

Abdominal ultrasound examination incidentally found most hypoechoic lesions

smaller 2 cm without clinical symptoms ndash which is typical for incidentalomas

Histoplasmosis is a geographically restricted form of

fungal infection Adrenal involvement is seen in disseminated disease but sometimes it may be the only site of demonstrable disease Early diagnosis and treatment may save the patient from catastrophic adrenal insufficiency We present two patients showing bilateral adrenomegaly on ultrasonography and contrast-enhanced CT and was diagnosed to have histoplasmosis on fine-needle aspiration cytology

Histoplasmosis is an infective condition caused by a

dimorphic saprophytic fungus Histoplasma capsulatum and is acquired by inhalation of its spores Soil rich in bird and bat dropping is its natural habitat and it exists as a mycelium in the atmosphere

Both adrenal gland were enlarged and hypoechoic at US study

US show bilateral hypoechoic lesions and CT showed peripherally enhancing hypodense bilateral adrenals with peripheral rim and septate enhancement

ULTRASOUND OF THE ADULT KIDNEY ndash Normal

Coronal scan plane for the Right Kidney Longitudinal Normal Kidney

Scan plane transverse kidney Transverse normal image

Common anatomical variantsAtrophic small kidneyHorseshoe kidneyEctopic kidneyDuplex kidneyCross fused ectopiaUnilateral renal agenesis

COMMON PATHOLOGYCalculusRenal cyst Cortical and Para-pelvicAngiomyolipmaRenal infectionRenal cell carcinomaTransitional cell carcinomaMedullary sponge kidneyPolycystic kidney disease

Horseshoe kidney A transverse and longitudinal view across the midline showing the isthmus across the aorta

Cross fused ectopic kidney The left kidney is fused to the lower pole of the right kidney

A baggy extra-renal pelvis

Pelvic ectopic kidney

UltrasonographyOn sonograms stones are demonstrated as bright echogenic foci with posterior acoustic shadowing Stones are visualized fairly well with US in the kidneys and the distal ureter at or near the UVJ especially if dilatation is present US is good for the visualization of complications such as hydronephrosis (or other signs of obstruction) however some patients with acute obstruction have little or no dilationIn particular US is helpful in evaluating those with renal insufficiency or contraindications for the use of contrast media however US is often skipped in favor of nonenhanced CTIn addition US is good for characterizing lucent filling defects that are visualized as stones on IVU However US does not provide direct physiologic information regarding the degree of obstruction Doppler imaging may demonstrate a high resistive index in acute obstruction but this may not occur immediately or after forniceal rupture Absence of the ureteral jet as visualized with color Doppler on the symptomatic side is presumptive evidence for a high-grade obstruction in a well-hydrated patient

Degree of confidenceUS is very insensitive for stones especially stones smaller than 2 mm stones at the UPJ or stones in the mid ureter Fowler et al suggest that US has a sensitivity as low as 24 compared with nonenhanced CT Furthermore estimations of stone size may not be accurate Compared with nonenhanced CT US is more dependent on the operators ability and more time consuming

False positivesnegativesUS is fairly specific when stones are seen with a specificity as high as 90 With US matrix or indinavir stones may have soft tissue echogenicity without shadowing False-positive findings may result from renal vascular calcifications False-positive diagnoses of hydronephrosis also result from dilated vascular structures in the renal hilum Doppler imaging is helpful in distinguishing dilated vascular structures from hydronephrosis

Renal sonogram demonstrates an echogenic shadowing calculus in the renal collecting system with hydronephrosis

US images for renal stones

US images of staghorn stones

US images for ureteric stones

US images for nephrocalcinosis

Renal cystA renal cyst is a fluid collection in the kidney There are several types based on the Bosniak classification The majority are benign simple cysts that can be monitored and not intervened upon However some are cancerous or are suspicious for cancer and are commonly removed in a surgical procedure called nephrectomyNumerous renal cysts are seen in the cystic kidney diseases which include polycystic kidney diseaseand medullary sponge kidney

The Bosniak classification categorizes renal cysts into five groupsCategory I

Benign simple cyst with thin wall without septa calcifications or solid

components

It does not enhance with contrast and has a density equal to that of water

Category IIBenign cyst with a few thin septa which may contain fine calcifications or a

small

segment of mildly thickened calcification This includes homogenous

high-attenuation lesions less than 3 cm with sharp margins(Rich Kosak) but

without enhancement

Category IIFWell marginated cysts with a number of thin septa with or without mild

enhancement or thickening of septa Calcifications may be present these

may be thick and nodular There are no enhancing soft tissue components

This also includes nonenhancing high-attenuation lesions that are completely

contained within the kidney and are 3 cm or larger

Category IIIIndeterminate cystic masses with thickened irregular septa with enhancement

Category IVMalignant cystic masses with all the characteristics of category III lesions

but also with enhancing soft tissue components independent of but adjacent

to the septa

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 11)

Classic findings of a simple cyst(Bosniak category 111)

Classic findings of a simple cyst(Bosniak category 1V)

Para-pelvic cyst USamp CT images

US of polycystic kidney disease

Renal infection

US of acute pyelonephritis

Acute bacterial pyelonephritis (a) US scan shows a wedge-shaped hyperechoic focus (arrowhead) in the upper pole of the right kidney related to acute bacterial pyelonephritis (b) Color flow US image demonstrates diminished flow through the involved area

US and color Doppler images of right kidney shows focal hyperechoic nephritis with decreased perfusion at the Doppler US

US and color Doppler images of kidney shows two multifocal nephritis with decreased perfusion at the Doppler US

Masslike appearance of acute bacterial pyelonephritis US and CT images

Emphysematous pyelonephritis (a) US image shows nondependent echoes within the left kidney that demonstrate a ring-down artifact (b) Corresponding CT scan helps confirm that this pattern is caused by intraparenchymal air

Xanthogranulomatous pyelonephritis (a) Contrast-enhanced CT scan demonstrates bilateral staghorn calculi with distention of the right collecting system secondary to inflammatory debris (b) US scan also shows the dilated

collecting system (arrowheads) and a shadowing calculus (arrow)

Early and mature abscess cavities (a) US scan demonstrates a geographic hypoechoic focus from an abscess in the upper pole of the right kidney (b) On a US scan of a more mature abscess the cavity is better defined with a visible pseudocapsule and through transmission that is evidenced by increased echogenicity deep to the upper pole lesion

Pyohydronephrosis

Pyohydronephrosis

Renal hydatidosis is an insidious disease and patients

often present with nonspecific clinical signs or symptoms Presenting complaints are dull flank pain hematuria palpable flank mass hypertension and renal colic

Disseminated abdominal retroperitoneal and pelvic hydatid disease (a) The right kidney is pushed to the midline and the left kidney is hydronephrotic and shrunken by retroperitoneal hydatid cysts (b) Ultrasound of the abdomen showing cystic lesions in the retroperitoneum in the position of the kidneys

Hydatid disease of the kidney US and CT images

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 10: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Cystic anechoic mass in the left adrenal gland representing a hemorrhage

Echo -free intra-adrenal hemorrhage in a

newborn with high resolution ultrasound

Adrenal Abscess An abscess of the adrenal glands is rarely anechoic It is usually hypoechoic

or has a complex echo structure When the contents are anechoic the clinical

and laboratory findings can differentiate the lesion from an ordinary cyst The

wall is irregular and distal acoustic enhancement may be present

Transverse ultrasound image reveals anechoic cystic masses containing internal echoes and debris at bilateral supra renal area and right is measuring more than left

Longitudinal ultrasound image reveals anechoic cystic abscess With wall calcification and needle in the lesion during procedure

Benign adrenal gland tumours Adenoma Adenomas are uniformly hypoechoic with smooth margins and a round to oval shape although some lesions have scalloped borders (polycyclic) Adenomas occasionally have an inhomogeneous appearance Autopsy statistics indicate that they are quite common (10ndash20) but most adenomas (90) produce no endocrine symptoms they are bdquosilentldquo and too small to be seen with ultrasound The average size of adenomas in one study was 15 cm although they may exceed 5 cm in diameter In a small percentage of patients adenomas are bilateral Functioning and nonfunctioning adenomas are indistinguishable by their sonographic features

Medial to the upper pole of the right kidney is a sharply circumscribed hypoechoic mass typical adrenal adenoma

Hypoechoic sharply circumscribed adenoma of the right adrenal gland discovered

at routine ultrasound (confirmed by ultrasound-guided fine-needle aspiration)

Approximately 5 cm hypoechoic inhomogenous mass above the right kidney adenoma (incidentaloma) without associated symptoms detected at routine upper abdominal ultrasound Histology identified as an adrenal adenoma (most common incidentaloma)

Lipoma Myelolipoma

Lipoma A pure lipoma of the adrenal glands has

smooth margins and high homogeneous

echogenicity In contrast to the mixed tissues of

myolipoma posterior acoustic shadowing does

not occur Lipoma is rare and shows no proliferative tendency

Myelolipoma Adrenal myelolipoma has smooth margins and a homogeneous hyperechoic structure It resembles a renal angiomyolipoma in its sonographic features Posterior acoustic shadowing is often present Malignant transformation is not known to occur The tumour consists histologically of fat and bone marrow tissue (hematopoietic cells and reticular cells) Intratumoral hemorrhage and calcifications may be seen

Homogeneous sharply circumscribed hyperechoic tumour adjacent to the right kidney Classic adrenal myelolipoma

In CEUS a myelolipoma shows a nearly constant

contrast enhancement without wash out

Calcification Complete or partial calcification of the adrenal glands is characterized by a

typical echo complex with a posterior acoustic shadow Calcifications can

result from a retained intra-adrenal hemorrhage or a prior inflammatory

process (eg tuberculosis) Patients occasionally show the clinical

manifestations of Addison disease However calcifications can also develop in

tumours (carcinoma metastases Pheochromocytoma adenoma)

In the proximal left kidney in the adrenal gland region wefound a classical calcification with dorsal acoustic shadow

Small calcifications also occur in tumours of adrenal gland most often observed in pheochromocytoma

Malignant adrenal gland tumours Metastases With their rich blood supply the adrenal glands are the fourth

most frequent site for hematogenous metastasis Metastases

to the adrenal glands account for the majority of solid adrenal

tumours after the adenomas

In contrast to adenomas these lesions are less homogeneous

and often have irregular margins The most common

primaries are bronchial carcinoma (25ndash30 ) breast

carcinoma and malignant melanoma Other possible sources

are gastrointestinal urological and gynecological tumours

(renal carcinoma gastric carcinoma pancreatic carcinoma

and others) Adrenal metastases are bilateral in up to 30 of

cases and this can produce the clinical manifestations of

Addison disease Bronchial carcinoma is virtually the only

tumour that is associated with isolated adrenal metastases

(in ca 15-20 )

Large metastasis from bronchial carcinoma on the right

side with a very inhomogeneous internal structure Solid

components are seen along with central liquid areas

Transverse scan shows a metastasis with a complex echo structure ldquowedgedrdquo between right lobe of the liver inferior vena cava the kidney and spinal column

Transverse scan of a metastasis of the right adrenal gland with complex structure beside a primary tumour of lung cancer

Partial metastases esp of lung cancer show

a wash out of contrast media in late phase

US examination longitudinal view Above the right kidney in the adrenal region a solid slightly inhomogeneous mass can be seen Neuroblastoma MRI examination

axial T2 weighted image Irregular large solid inhomogeneous retroperitoneal tumor

Pheochromocytoma Pheochromocytoma is a tumour of the adrenal medulla that is generally

detected sonographically (80ndash90 of cases) following the appearance

of clinical symptoms (hypertension and tachycardia caused by

increased catecholamine secretion)

Most pheochromocytomas are already several centimeters in diameter

when diagnosed They have smooth margins a round shape and a

nonhomogeneous or complex echo structure

Hypoechoic liquid components are also observed A spectrum of

appearances may be seen Pheochromocytomas are bilateral in

approximately 10 of cases and extra-adrenal in 10ndash20

The ldquoZuckerkandl organrdquo should be looked for at the level of the origin

of the inferior mesenteric artery anterior to the aorta

Other extra-adrenal sites are the renal hilum bladder wall and thorax

Pheochromocytoma is occasionally seen posterior to the renal vein in

transverse scans Rarely pheochromocytoma is diagnosed in the

setting of multiple endocrine neoplasia (MEN) From 2 to 5 of

pheochromocytomas are malignant Owing to the risk of inciting a

hypertensive crisis fine-needle aspiration biopsy causes discrepant

discussions about FNB

Nonhomogeneous tumour with a hyperechoic center (positive endocrine test increased catecholamine secretion) ndash Pheochromocytoma

Large functionally active pheochromocytoma (7 cm in diameter) The scan shows that most of tumour is hypoechoic with some hyperechoic regions

Lymphoma The adrenal region is a rare extranodal site of occurrence for lymphoma

Foci of lymphomatous infiltration have smooth borders and are

hypoechoic Differentiation is required from lymphomas in the renal or

splenic hilum If invasion by lymphoma is suspected other nodal

stations should be scanned and commonly infiltrated organs (spleen

liver) should be closely scrutinized

Perisplenic lymphoma in the left adrenal region of a patient with B-cell lymphoma

Colour Doppler shows hypervascularisation of the lymphatic tissue

Adrenal Carcinoma Adrenal carcinoma is usually inhomogeneous hypoechoic or echo complex with irregular margins It frequently infiltrates its surroundings and metastases can be demonstrated in the adrenal region and in other organs (eg the liver) The adrenal carcinoma is a very rare (1 17 million inhabitants) highly malignant tumour with a poor prognosis Adrenal carcinoma is indistinguishable sonographically from a metastasis although the visualization of additional tumours can advance the differential diagnosis Most adrenal carcinomas are hormone-producing Sometimes one can get evidence from detection of other tumour sign The tumour is usually detected only after it has reached considerable size (often gt8 cm) Intratumoral hemorrhage necrotic foci and calcifications may occur adding to the variegated appearance

Adrenal carcinoma may be hypoechoic or may have a complex echo structure Usually it

was relatively large when diagnosed (in this case 8 cm times 9 cm) and had irregular margins

Right adrenal adenocarcinoma A Sonogram showing a complex mass with cystic changes in the right adrenal gland (arrows) B Computed tomogram showing the mass (arrows)

Incidentaloma An incidentaloma is an adrenal tumour that is detected incidentally in an asymptomatic patient Incidentalomas are found in 1 of CT examinations They are much less common in ultrasound examinations because of the difficulty in defining small lesions (lt 2 cm) The predominantly hypoechoic tumours account for the great majority of incidentalomas shows the algorithm used in the investigation of incidentalomas Approximately 10 to 15 of these tumours are hormonally active In some cases ultrasound-guided fine-needle aspiration can also aid in the evaluation of incidentalomas but only ca 1 to 2 of these tumours are malignant

Abdominal ultrasound examination incidentally found most hypoechoic lesions

smaller 2 cm without clinical symptoms ndash which is typical for incidentalomas

Histoplasmosis is a geographically restricted form of

fungal infection Adrenal involvement is seen in disseminated disease but sometimes it may be the only site of demonstrable disease Early diagnosis and treatment may save the patient from catastrophic adrenal insufficiency We present two patients showing bilateral adrenomegaly on ultrasonography and contrast-enhanced CT and was diagnosed to have histoplasmosis on fine-needle aspiration cytology

Histoplasmosis is an infective condition caused by a

dimorphic saprophytic fungus Histoplasma capsulatum and is acquired by inhalation of its spores Soil rich in bird and bat dropping is its natural habitat and it exists as a mycelium in the atmosphere

Both adrenal gland were enlarged and hypoechoic at US study

US show bilateral hypoechoic lesions and CT showed peripherally enhancing hypodense bilateral adrenals with peripheral rim and septate enhancement

ULTRASOUND OF THE ADULT KIDNEY ndash Normal

Coronal scan plane for the Right Kidney Longitudinal Normal Kidney

Scan plane transverse kidney Transverse normal image

Common anatomical variantsAtrophic small kidneyHorseshoe kidneyEctopic kidneyDuplex kidneyCross fused ectopiaUnilateral renal agenesis

COMMON PATHOLOGYCalculusRenal cyst Cortical and Para-pelvicAngiomyolipmaRenal infectionRenal cell carcinomaTransitional cell carcinomaMedullary sponge kidneyPolycystic kidney disease

Horseshoe kidney A transverse and longitudinal view across the midline showing the isthmus across the aorta

Cross fused ectopic kidney The left kidney is fused to the lower pole of the right kidney

A baggy extra-renal pelvis

Pelvic ectopic kidney

UltrasonographyOn sonograms stones are demonstrated as bright echogenic foci with posterior acoustic shadowing Stones are visualized fairly well with US in the kidneys and the distal ureter at or near the UVJ especially if dilatation is present US is good for the visualization of complications such as hydronephrosis (or other signs of obstruction) however some patients with acute obstruction have little or no dilationIn particular US is helpful in evaluating those with renal insufficiency or contraindications for the use of contrast media however US is often skipped in favor of nonenhanced CTIn addition US is good for characterizing lucent filling defects that are visualized as stones on IVU However US does not provide direct physiologic information regarding the degree of obstruction Doppler imaging may demonstrate a high resistive index in acute obstruction but this may not occur immediately or after forniceal rupture Absence of the ureteral jet as visualized with color Doppler on the symptomatic side is presumptive evidence for a high-grade obstruction in a well-hydrated patient

Degree of confidenceUS is very insensitive for stones especially stones smaller than 2 mm stones at the UPJ or stones in the mid ureter Fowler et al suggest that US has a sensitivity as low as 24 compared with nonenhanced CT Furthermore estimations of stone size may not be accurate Compared with nonenhanced CT US is more dependent on the operators ability and more time consuming

False positivesnegativesUS is fairly specific when stones are seen with a specificity as high as 90 With US matrix or indinavir stones may have soft tissue echogenicity without shadowing False-positive findings may result from renal vascular calcifications False-positive diagnoses of hydronephrosis also result from dilated vascular structures in the renal hilum Doppler imaging is helpful in distinguishing dilated vascular structures from hydronephrosis

Renal sonogram demonstrates an echogenic shadowing calculus in the renal collecting system with hydronephrosis

US images for renal stones

US images of staghorn stones

US images for ureteric stones

US images for nephrocalcinosis

Renal cystA renal cyst is a fluid collection in the kidney There are several types based on the Bosniak classification The majority are benign simple cysts that can be monitored and not intervened upon However some are cancerous or are suspicious for cancer and are commonly removed in a surgical procedure called nephrectomyNumerous renal cysts are seen in the cystic kidney diseases which include polycystic kidney diseaseand medullary sponge kidney

The Bosniak classification categorizes renal cysts into five groupsCategory I

Benign simple cyst with thin wall without septa calcifications or solid

components

It does not enhance with contrast and has a density equal to that of water

Category IIBenign cyst with a few thin septa which may contain fine calcifications or a

small

segment of mildly thickened calcification This includes homogenous

high-attenuation lesions less than 3 cm with sharp margins(Rich Kosak) but

without enhancement

Category IIFWell marginated cysts with a number of thin septa with or without mild

enhancement or thickening of septa Calcifications may be present these

may be thick and nodular There are no enhancing soft tissue components

This also includes nonenhancing high-attenuation lesions that are completely

contained within the kidney and are 3 cm or larger

Category IIIIndeterminate cystic masses with thickened irregular septa with enhancement

Category IVMalignant cystic masses with all the characteristics of category III lesions

but also with enhancing soft tissue components independent of but adjacent

to the septa

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 11)

Classic findings of a simple cyst(Bosniak category 111)

Classic findings of a simple cyst(Bosniak category 1V)

Para-pelvic cyst USamp CT images

US of polycystic kidney disease

Renal infection

US of acute pyelonephritis

Acute bacterial pyelonephritis (a) US scan shows a wedge-shaped hyperechoic focus (arrowhead) in the upper pole of the right kidney related to acute bacterial pyelonephritis (b) Color flow US image demonstrates diminished flow through the involved area

US and color Doppler images of right kidney shows focal hyperechoic nephritis with decreased perfusion at the Doppler US

US and color Doppler images of kidney shows two multifocal nephritis with decreased perfusion at the Doppler US

Masslike appearance of acute bacterial pyelonephritis US and CT images

Emphysematous pyelonephritis (a) US image shows nondependent echoes within the left kidney that demonstrate a ring-down artifact (b) Corresponding CT scan helps confirm that this pattern is caused by intraparenchymal air

Xanthogranulomatous pyelonephritis (a) Contrast-enhanced CT scan demonstrates bilateral staghorn calculi with distention of the right collecting system secondary to inflammatory debris (b) US scan also shows the dilated

collecting system (arrowheads) and a shadowing calculus (arrow)

Early and mature abscess cavities (a) US scan demonstrates a geographic hypoechoic focus from an abscess in the upper pole of the right kidney (b) On a US scan of a more mature abscess the cavity is better defined with a visible pseudocapsule and through transmission that is evidenced by increased echogenicity deep to the upper pole lesion

Pyohydronephrosis

Pyohydronephrosis

Renal hydatidosis is an insidious disease and patients

often present with nonspecific clinical signs or symptoms Presenting complaints are dull flank pain hematuria palpable flank mass hypertension and renal colic

Disseminated abdominal retroperitoneal and pelvic hydatid disease (a) The right kidney is pushed to the midline and the left kidney is hydronephrotic and shrunken by retroperitoneal hydatid cysts (b) Ultrasound of the abdomen showing cystic lesions in the retroperitoneum in the position of the kidneys

Hydatid disease of the kidney US and CT images

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 11: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Echo -free intra-adrenal hemorrhage in a

newborn with high resolution ultrasound

Adrenal Abscess An abscess of the adrenal glands is rarely anechoic It is usually hypoechoic

or has a complex echo structure When the contents are anechoic the clinical

and laboratory findings can differentiate the lesion from an ordinary cyst The

wall is irregular and distal acoustic enhancement may be present

Transverse ultrasound image reveals anechoic cystic masses containing internal echoes and debris at bilateral supra renal area and right is measuring more than left

Longitudinal ultrasound image reveals anechoic cystic abscess With wall calcification and needle in the lesion during procedure

Benign adrenal gland tumours Adenoma Adenomas are uniformly hypoechoic with smooth margins and a round to oval shape although some lesions have scalloped borders (polycyclic) Adenomas occasionally have an inhomogeneous appearance Autopsy statistics indicate that they are quite common (10ndash20) but most adenomas (90) produce no endocrine symptoms they are bdquosilentldquo and too small to be seen with ultrasound The average size of adenomas in one study was 15 cm although they may exceed 5 cm in diameter In a small percentage of patients adenomas are bilateral Functioning and nonfunctioning adenomas are indistinguishable by their sonographic features

Medial to the upper pole of the right kidney is a sharply circumscribed hypoechoic mass typical adrenal adenoma

Hypoechoic sharply circumscribed adenoma of the right adrenal gland discovered

at routine ultrasound (confirmed by ultrasound-guided fine-needle aspiration)

Approximately 5 cm hypoechoic inhomogenous mass above the right kidney adenoma (incidentaloma) without associated symptoms detected at routine upper abdominal ultrasound Histology identified as an adrenal adenoma (most common incidentaloma)

Lipoma Myelolipoma

Lipoma A pure lipoma of the adrenal glands has

smooth margins and high homogeneous

echogenicity In contrast to the mixed tissues of

myolipoma posterior acoustic shadowing does

not occur Lipoma is rare and shows no proliferative tendency

Myelolipoma Adrenal myelolipoma has smooth margins and a homogeneous hyperechoic structure It resembles a renal angiomyolipoma in its sonographic features Posterior acoustic shadowing is often present Malignant transformation is not known to occur The tumour consists histologically of fat and bone marrow tissue (hematopoietic cells and reticular cells) Intratumoral hemorrhage and calcifications may be seen

Homogeneous sharply circumscribed hyperechoic tumour adjacent to the right kidney Classic adrenal myelolipoma

In CEUS a myelolipoma shows a nearly constant

contrast enhancement without wash out

Calcification Complete or partial calcification of the adrenal glands is characterized by a

typical echo complex with a posterior acoustic shadow Calcifications can

result from a retained intra-adrenal hemorrhage or a prior inflammatory

process (eg tuberculosis) Patients occasionally show the clinical

manifestations of Addison disease However calcifications can also develop in

tumours (carcinoma metastases Pheochromocytoma adenoma)

In the proximal left kidney in the adrenal gland region wefound a classical calcification with dorsal acoustic shadow

Small calcifications also occur in tumours of adrenal gland most often observed in pheochromocytoma

Malignant adrenal gland tumours Metastases With their rich blood supply the adrenal glands are the fourth

most frequent site for hematogenous metastasis Metastases

to the adrenal glands account for the majority of solid adrenal

tumours after the adenomas

In contrast to adenomas these lesions are less homogeneous

and often have irregular margins The most common

primaries are bronchial carcinoma (25ndash30 ) breast

carcinoma and malignant melanoma Other possible sources

are gastrointestinal urological and gynecological tumours

(renal carcinoma gastric carcinoma pancreatic carcinoma

and others) Adrenal metastases are bilateral in up to 30 of

cases and this can produce the clinical manifestations of

Addison disease Bronchial carcinoma is virtually the only

tumour that is associated with isolated adrenal metastases

(in ca 15-20 )

Large metastasis from bronchial carcinoma on the right

side with a very inhomogeneous internal structure Solid

components are seen along with central liquid areas

Transverse scan shows a metastasis with a complex echo structure ldquowedgedrdquo between right lobe of the liver inferior vena cava the kidney and spinal column

Transverse scan of a metastasis of the right adrenal gland with complex structure beside a primary tumour of lung cancer

Partial metastases esp of lung cancer show

a wash out of contrast media in late phase

US examination longitudinal view Above the right kidney in the adrenal region a solid slightly inhomogeneous mass can be seen Neuroblastoma MRI examination

axial T2 weighted image Irregular large solid inhomogeneous retroperitoneal tumor

Pheochromocytoma Pheochromocytoma is a tumour of the adrenal medulla that is generally

detected sonographically (80ndash90 of cases) following the appearance

of clinical symptoms (hypertension and tachycardia caused by

increased catecholamine secretion)

Most pheochromocytomas are already several centimeters in diameter

when diagnosed They have smooth margins a round shape and a

nonhomogeneous or complex echo structure

Hypoechoic liquid components are also observed A spectrum of

appearances may be seen Pheochromocytomas are bilateral in

approximately 10 of cases and extra-adrenal in 10ndash20

The ldquoZuckerkandl organrdquo should be looked for at the level of the origin

of the inferior mesenteric artery anterior to the aorta

Other extra-adrenal sites are the renal hilum bladder wall and thorax

Pheochromocytoma is occasionally seen posterior to the renal vein in

transverse scans Rarely pheochromocytoma is diagnosed in the

setting of multiple endocrine neoplasia (MEN) From 2 to 5 of

pheochromocytomas are malignant Owing to the risk of inciting a

hypertensive crisis fine-needle aspiration biopsy causes discrepant

discussions about FNB

Nonhomogeneous tumour with a hyperechoic center (positive endocrine test increased catecholamine secretion) ndash Pheochromocytoma

Large functionally active pheochromocytoma (7 cm in diameter) The scan shows that most of tumour is hypoechoic with some hyperechoic regions

Lymphoma The adrenal region is a rare extranodal site of occurrence for lymphoma

Foci of lymphomatous infiltration have smooth borders and are

hypoechoic Differentiation is required from lymphomas in the renal or

splenic hilum If invasion by lymphoma is suspected other nodal

stations should be scanned and commonly infiltrated organs (spleen

liver) should be closely scrutinized

Perisplenic lymphoma in the left adrenal region of a patient with B-cell lymphoma

Colour Doppler shows hypervascularisation of the lymphatic tissue

Adrenal Carcinoma Adrenal carcinoma is usually inhomogeneous hypoechoic or echo complex with irregular margins It frequently infiltrates its surroundings and metastases can be demonstrated in the adrenal region and in other organs (eg the liver) The adrenal carcinoma is a very rare (1 17 million inhabitants) highly malignant tumour with a poor prognosis Adrenal carcinoma is indistinguishable sonographically from a metastasis although the visualization of additional tumours can advance the differential diagnosis Most adrenal carcinomas are hormone-producing Sometimes one can get evidence from detection of other tumour sign The tumour is usually detected only after it has reached considerable size (often gt8 cm) Intratumoral hemorrhage necrotic foci and calcifications may occur adding to the variegated appearance

Adrenal carcinoma may be hypoechoic or may have a complex echo structure Usually it

was relatively large when diagnosed (in this case 8 cm times 9 cm) and had irregular margins

Right adrenal adenocarcinoma A Sonogram showing a complex mass with cystic changes in the right adrenal gland (arrows) B Computed tomogram showing the mass (arrows)

Incidentaloma An incidentaloma is an adrenal tumour that is detected incidentally in an asymptomatic patient Incidentalomas are found in 1 of CT examinations They are much less common in ultrasound examinations because of the difficulty in defining small lesions (lt 2 cm) The predominantly hypoechoic tumours account for the great majority of incidentalomas shows the algorithm used in the investigation of incidentalomas Approximately 10 to 15 of these tumours are hormonally active In some cases ultrasound-guided fine-needle aspiration can also aid in the evaluation of incidentalomas but only ca 1 to 2 of these tumours are malignant

Abdominal ultrasound examination incidentally found most hypoechoic lesions

smaller 2 cm without clinical symptoms ndash which is typical for incidentalomas

Histoplasmosis is a geographically restricted form of

fungal infection Adrenal involvement is seen in disseminated disease but sometimes it may be the only site of demonstrable disease Early diagnosis and treatment may save the patient from catastrophic adrenal insufficiency We present two patients showing bilateral adrenomegaly on ultrasonography and contrast-enhanced CT and was diagnosed to have histoplasmosis on fine-needle aspiration cytology

Histoplasmosis is an infective condition caused by a

dimorphic saprophytic fungus Histoplasma capsulatum and is acquired by inhalation of its spores Soil rich in bird and bat dropping is its natural habitat and it exists as a mycelium in the atmosphere

Both adrenal gland were enlarged and hypoechoic at US study

US show bilateral hypoechoic lesions and CT showed peripherally enhancing hypodense bilateral adrenals with peripheral rim and septate enhancement

ULTRASOUND OF THE ADULT KIDNEY ndash Normal

Coronal scan plane for the Right Kidney Longitudinal Normal Kidney

Scan plane transverse kidney Transverse normal image

Common anatomical variantsAtrophic small kidneyHorseshoe kidneyEctopic kidneyDuplex kidneyCross fused ectopiaUnilateral renal agenesis

COMMON PATHOLOGYCalculusRenal cyst Cortical and Para-pelvicAngiomyolipmaRenal infectionRenal cell carcinomaTransitional cell carcinomaMedullary sponge kidneyPolycystic kidney disease

Horseshoe kidney A transverse and longitudinal view across the midline showing the isthmus across the aorta

Cross fused ectopic kidney The left kidney is fused to the lower pole of the right kidney

A baggy extra-renal pelvis

Pelvic ectopic kidney

UltrasonographyOn sonograms stones are demonstrated as bright echogenic foci with posterior acoustic shadowing Stones are visualized fairly well with US in the kidneys and the distal ureter at or near the UVJ especially if dilatation is present US is good for the visualization of complications such as hydronephrosis (or other signs of obstruction) however some patients with acute obstruction have little or no dilationIn particular US is helpful in evaluating those with renal insufficiency or contraindications for the use of contrast media however US is often skipped in favor of nonenhanced CTIn addition US is good for characterizing lucent filling defects that are visualized as stones on IVU However US does not provide direct physiologic information regarding the degree of obstruction Doppler imaging may demonstrate a high resistive index in acute obstruction but this may not occur immediately or after forniceal rupture Absence of the ureteral jet as visualized with color Doppler on the symptomatic side is presumptive evidence for a high-grade obstruction in a well-hydrated patient

Degree of confidenceUS is very insensitive for stones especially stones smaller than 2 mm stones at the UPJ or stones in the mid ureter Fowler et al suggest that US has a sensitivity as low as 24 compared with nonenhanced CT Furthermore estimations of stone size may not be accurate Compared with nonenhanced CT US is more dependent on the operators ability and more time consuming

False positivesnegativesUS is fairly specific when stones are seen with a specificity as high as 90 With US matrix or indinavir stones may have soft tissue echogenicity without shadowing False-positive findings may result from renal vascular calcifications False-positive diagnoses of hydronephrosis also result from dilated vascular structures in the renal hilum Doppler imaging is helpful in distinguishing dilated vascular structures from hydronephrosis

Renal sonogram demonstrates an echogenic shadowing calculus in the renal collecting system with hydronephrosis

US images for renal stones

US images of staghorn stones

US images for ureteric stones

US images for nephrocalcinosis

Renal cystA renal cyst is a fluid collection in the kidney There are several types based on the Bosniak classification The majority are benign simple cysts that can be monitored and not intervened upon However some are cancerous or are suspicious for cancer and are commonly removed in a surgical procedure called nephrectomyNumerous renal cysts are seen in the cystic kidney diseases which include polycystic kidney diseaseand medullary sponge kidney

The Bosniak classification categorizes renal cysts into five groupsCategory I

Benign simple cyst with thin wall without septa calcifications or solid

components

It does not enhance with contrast and has a density equal to that of water

Category IIBenign cyst with a few thin septa which may contain fine calcifications or a

small

segment of mildly thickened calcification This includes homogenous

high-attenuation lesions less than 3 cm with sharp margins(Rich Kosak) but

without enhancement

Category IIFWell marginated cysts with a number of thin septa with or without mild

enhancement or thickening of septa Calcifications may be present these

may be thick and nodular There are no enhancing soft tissue components

This also includes nonenhancing high-attenuation lesions that are completely

contained within the kidney and are 3 cm or larger

Category IIIIndeterminate cystic masses with thickened irregular septa with enhancement

Category IVMalignant cystic masses with all the characteristics of category III lesions

but also with enhancing soft tissue components independent of but adjacent

to the septa

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 11)

Classic findings of a simple cyst(Bosniak category 111)

Classic findings of a simple cyst(Bosniak category 1V)

Para-pelvic cyst USamp CT images

US of polycystic kidney disease

Renal infection

US of acute pyelonephritis

Acute bacterial pyelonephritis (a) US scan shows a wedge-shaped hyperechoic focus (arrowhead) in the upper pole of the right kidney related to acute bacterial pyelonephritis (b) Color flow US image demonstrates diminished flow through the involved area

US and color Doppler images of right kidney shows focal hyperechoic nephritis with decreased perfusion at the Doppler US

US and color Doppler images of kidney shows two multifocal nephritis with decreased perfusion at the Doppler US

Masslike appearance of acute bacterial pyelonephritis US and CT images

Emphysematous pyelonephritis (a) US image shows nondependent echoes within the left kidney that demonstrate a ring-down artifact (b) Corresponding CT scan helps confirm that this pattern is caused by intraparenchymal air

Xanthogranulomatous pyelonephritis (a) Contrast-enhanced CT scan demonstrates bilateral staghorn calculi with distention of the right collecting system secondary to inflammatory debris (b) US scan also shows the dilated

collecting system (arrowheads) and a shadowing calculus (arrow)

Early and mature abscess cavities (a) US scan demonstrates a geographic hypoechoic focus from an abscess in the upper pole of the right kidney (b) On a US scan of a more mature abscess the cavity is better defined with a visible pseudocapsule and through transmission that is evidenced by increased echogenicity deep to the upper pole lesion

Pyohydronephrosis

Pyohydronephrosis

Renal hydatidosis is an insidious disease and patients

often present with nonspecific clinical signs or symptoms Presenting complaints are dull flank pain hematuria palpable flank mass hypertension and renal colic

Disseminated abdominal retroperitoneal and pelvic hydatid disease (a) The right kidney is pushed to the midline and the left kidney is hydronephrotic and shrunken by retroperitoneal hydatid cysts (b) Ultrasound of the abdomen showing cystic lesions in the retroperitoneum in the position of the kidneys

Hydatid disease of the kidney US and CT images

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 12: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Adrenal Abscess An abscess of the adrenal glands is rarely anechoic It is usually hypoechoic

or has a complex echo structure When the contents are anechoic the clinical

and laboratory findings can differentiate the lesion from an ordinary cyst The

wall is irregular and distal acoustic enhancement may be present

Transverse ultrasound image reveals anechoic cystic masses containing internal echoes and debris at bilateral supra renal area and right is measuring more than left

Longitudinal ultrasound image reveals anechoic cystic abscess With wall calcification and needle in the lesion during procedure

Benign adrenal gland tumours Adenoma Adenomas are uniformly hypoechoic with smooth margins and a round to oval shape although some lesions have scalloped borders (polycyclic) Adenomas occasionally have an inhomogeneous appearance Autopsy statistics indicate that they are quite common (10ndash20) but most adenomas (90) produce no endocrine symptoms they are bdquosilentldquo and too small to be seen with ultrasound The average size of adenomas in one study was 15 cm although they may exceed 5 cm in diameter In a small percentage of patients adenomas are bilateral Functioning and nonfunctioning adenomas are indistinguishable by their sonographic features

Medial to the upper pole of the right kidney is a sharply circumscribed hypoechoic mass typical adrenal adenoma

Hypoechoic sharply circumscribed adenoma of the right adrenal gland discovered

at routine ultrasound (confirmed by ultrasound-guided fine-needle aspiration)

Approximately 5 cm hypoechoic inhomogenous mass above the right kidney adenoma (incidentaloma) without associated symptoms detected at routine upper abdominal ultrasound Histology identified as an adrenal adenoma (most common incidentaloma)

Lipoma Myelolipoma

Lipoma A pure lipoma of the adrenal glands has

smooth margins and high homogeneous

echogenicity In contrast to the mixed tissues of

myolipoma posterior acoustic shadowing does

not occur Lipoma is rare and shows no proliferative tendency

Myelolipoma Adrenal myelolipoma has smooth margins and a homogeneous hyperechoic structure It resembles a renal angiomyolipoma in its sonographic features Posterior acoustic shadowing is often present Malignant transformation is not known to occur The tumour consists histologically of fat and bone marrow tissue (hematopoietic cells and reticular cells) Intratumoral hemorrhage and calcifications may be seen

Homogeneous sharply circumscribed hyperechoic tumour adjacent to the right kidney Classic adrenal myelolipoma

In CEUS a myelolipoma shows a nearly constant

contrast enhancement without wash out

Calcification Complete or partial calcification of the adrenal glands is characterized by a

typical echo complex with a posterior acoustic shadow Calcifications can

result from a retained intra-adrenal hemorrhage or a prior inflammatory

process (eg tuberculosis) Patients occasionally show the clinical

manifestations of Addison disease However calcifications can also develop in

tumours (carcinoma metastases Pheochromocytoma adenoma)

In the proximal left kidney in the adrenal gland region wefound a classical calcification with dorsal acoustic shadow

Small calcifications also occur in tumours of adrenal gland most often observed in pheochromocytoma

Malignant adrenal gland tumours Metastases With their rich blood supply the adrenal glands are the fourth

most frequent site for hematogenous metastasis Metastases

to the adrenal glands account for the majority of solid adrenal

tumours after the adenomas

In contrast to adenomas these lesions are less homogeneous

and often have irregular margins The most common

primaries are bronchial carcinoma (25ndash30 ) breast

carcinoma and malignant melanoma Other possible sources

are gastrointestinal urological and gynecological tumours

(renal carcinoma gastric carcinoma pancreatic carcinoma

and others) Adrenal metastases are bilateral in up to 30 of

cases and this can produce the clinical manifestations of

Addison disease Bronchial carcinoma is virtually the only

tumour that is associated with isolated adrenal metastases

(in ca 15-20 )

Large metastasis from bronchial carcinoma on the right

side with a very inhomogeneous internal structure Solid

components are seen along with central liquid areas

Transverse scan shows a metastasis with a complex echo structure ldquowedgedrdquo between right lobe of the liver inferior vena cava the kidney and spinal column

Transverse scan of a metastasis of the right adrenal gland with complex structure beside a primary tumour of lung cancer

Partial metastases esp of lung cancer show

a wash out of contrast media in late phase

US examination longitudinal view Above the right kidney in the adrenal region a solid slightly inhomogeneous mass can be seen Neuroblastoma MRI examination

axial T2 weighted image Irregular large solid inhomogeneous retroperitoneal tumor

Pheochromocytoma Pheochromocytoma is a tumour of the adrenal medulla that is generally

detected sonographically (80ndash90 of cases) following the appearance

of clinical symptoms (hypertension and tachycardia caused by

increased catecholamine secretion)

Most pheochromocytomas are already several centimeters in diameter

when diagnosed They have smooth margins a round shape and a

nonhomogeneous or complex echo structure

Hypoechoic liquid components are also observed A spectrum of

appearances may be seen Pheochromocytomas are bilateral in

approximately 10 of cases and extra-adrenal in 10ndash20

The ldquoZuckerkandl organrdquo should be looked for at the level of the origin

of the inferior mesenteric artery anterior to the aorta

Other extra-adrenal sites are the renal hilum bladder wall and thorax

Pheochromocytoma is occasionally seen posterior to the renal vein in

transverse scans Rarely pheochromocytoma is diagnosed in the

setting of multiple endocrine neoplasia (MEN) From 2 to 5 of

pheochromocytomas are malignant Owing to the risk of inciting a

hypertensive crisis fine-needle aspiration biopsy causes discrepant

discussions about FNB

Nonhomogeneous tumour with a hyperechoic center (positive endocrine test increased catecholamine secretion) ndash Pheochromocytoma

Large functionally active pheochromocytoma (7 cm in diameter) The scan shows that most of tumour is hypoechoic with some hyperechoic regions

Lymphoma The adrenal region is a rare extranodal site of occurrence for lymphoma

Foci of lymphomatous infiltration have smooth borders and are

hypoechoic Differentiation is required from lymphomas in the renal or

splenic hilum If invasion by lymphoma is suspected other nodal

stations should be scanned and commonly infiltrated organs (spleen

liver) should be closely scrutinized

Perisplenic lymphoma in the left adrenal region of a patient with B-cell lymphoma

Colour Doppler shows hypervascularisation of the lymphatic tissue

Adrenal Carcinoma Adrenal carcinoma is usually inhomogeneous hypoechoic or echo complex with irregular margins It frequently infiltrates its surroundings and metastases can be demonstrated in the adrenal region and in other organs (eg the liver) The adrenal carcinoma is a very rare (1 17 million inhabitants) highly malignant tumour with a poor prognosis Adrenal carcinoma is indistinguishable sonographically from a metastasis although the visualization of additional tumours can advance the differential diagnosis Most adrenal carcinomas are hormone-producing Sometimes one can get evidence from detection of other tumour sign The tumour is usually detected only after it has reached considerable size (often gt8 cm) Intratumoral hemorrhage necrotic foci and calcifications may occur adding to the variegated appearance

Adrenal carcinoma may be hypoechoic or may have a complex echo structure Usually it

was relatively large when diagnosed (in this case 8 cm times 9 cm) and had irregular margins

Right adrenal adenocarcinoma A Sonogram showing a complex mass with cystic changes in the right adrenal gland (arrows) B Computed tomogram showing the mass (arrows)

Incidentaloma An incidentaloma is an adrenal tumour that is detected incidentally in an asymptomatic patient Incidentalomas are found in 1 of CT examinations They are much less common in ultrasound examinations because of the difficulty in defining small lesions (lt 2 cm) The predominantly hypoechoic tumours account for the great majority of incidentalomas shows the algorithm used in the investigation of incidentalomas Approximately 10 to 15 of these tumours are hormonally active In some cases ultrasound-guided fine-needle aspiration can also aid in the evaluation of incidentalomas but only ca 1 to 2 of these tumours are malignant

Abdominal ultrasound examination incidentally found most hypoechoic lesions

smaller 2 cm without clinical symptoms ndash which is typical for incidentalomas

Histoplasmosis is a geographically restricted form of

fungal infection Adrenal involvement is seen in disseminated disease but sometimes it may be the only site of demonstrable disease Early diagnosis and treatment may save the patient from catastrophic adrenal insufficiency We present two patients showing bilateral adrenomegaly on ultrasonography and contrast-enhanced CT and was diagnosed to have histoplasmosis on fine-needle aspiration cytology

Histoplasmosis is an infective condition caused by a

dimorphic saprophytic fungus Histoplasma capsulatum and is acquired by inhalation of its spores Soil rich in bird and bat dropping is its natural habitat and it exists as a mycelium in the atmosphere

Both adrenal gland were enlarged and hypoechoic at US study

US show bilateral hypoechoic lesions and CT showed peripherally enhancing hypodense bilateral adrenals with peripheral rim and septate enhancement

ULTRASOUND OF THE ADULT KIDNEY ndash Normal

Coronal scan plane for the Right Kidney Longitudinal Normal Kidney

Scan plane transverse kidney Transverse normal image

Common anatomical variantsAtrophic small kidneyHorseshoe kidneyEctopic kidneyDuplex kidneyCross fused ectopiaUnilateral renal agenesis

COMMON PATHOLOGYCalculusRenal cyst Cortical and Para-pelvicAngiomyolipmaRenal infectionRenal cell carcinomaTransitional cell carcinomaMedullary sponge kidneyPolycystic kidney disease

Horseshoe kidney A transverse and longitudinal view across the midline showing the isthmus across the aorta

Cross fused ectopic kidney The left kidney is fused to the lower pole of the right kidney

A baggy extra-renal pelvis

Pelvic ectopic kidney

UltrasonographyOn sonograms stones are demonstrated as bright echogenic foci with posterior acoustic shadowing Stones are visualized fairly well with US in the kidneys and the distal ureter at or near the UVJ especially if dilatation is present US is good for the visualization of complications such as hydronephrosis (or other signs of obstruction) however some patients with acute obstruction have little or no dilationIn particular US is helpful in evaluating those with renal insufficiency or contraindications for the use of contrast media however US is often skipped in favor of nonenhanced CTIn addition US is good for characterizing lucent filling defects that are visualized as stones on IVU However US does not provide direct physiologic information regarding the degree of obstruction Doppler imaging may demonstrate a high resistive index in acute obstruction but this may not occur immediately or after forniceal rupture Absence of the ureteral jet as visualized with color Doppler on the symptomatic side is presumptive evidence for a high-grade obstruction in a well-hydrated patient

Degree of confidenceUS is very insensitive for stones especially stones smaller than 2 mm stones at the UPJ or stones in the mid ureter Fowler et al suggest that US has a sensitivity as low as 24 compared with nonenhanced CT Furthermore estimations of stone size may not be accurate Compared with nonenhanced CT US is more dependent on the operators ability and more time consuming

False positivesnegativesUS is fairly specific when stones are seen with a specificity as high as 90 With US matrix or indinavir stones may have soft tissue echogenicity without shadowing False-positive findings may result from renal vascular calcifications False-positive diagnoses of hydronephrosis also result from dilated vascular structures in the renal hilum Doppler imaging is helpful in distinguishing dilated vascular structures from hydronephrosis

Renal sonogram demonstrates an echogenic shadowing calculus in the renal collecting system with hydronephrosis

US images for renal stones

US images of staghorn stones

US images for ureteric stones

US images for nephrocalcinosis

Renal cystA renal cyst is a fluid collection in the kidney There are several types based on the Bosniak classification The majority are benign simple cysts that can be monitored and not intervened upon However some are cancerous or are suspicious for cancer and are commonly removed in a surgical procedure called nephrectomyNumerous renal cysts are seen in the cystic kidney diseases which include polycystic kidney diseaseand medullary sponge kidney

The Bosniak classification categorizes renal cysts into five groupsCategory I

Benign simple cyst with thin wall without septa calcifications or solid

components

It does not enhance with contrast and has a density equal to that of water

Category IIBenign cyst with a few thin septa which may contain fine calcifications or a

small

segment of mildly thickened calcification This includes homogenous

high-attenuation lesions less than 3 cm with sharp margins(Rich Kosak) but

without enhancement

Category IIFWell marginated cysts with a number of thin septa with or without mild

enhancement or thickening of septa Calcifications may be present these

may be thick and nodular There are no enhancing soft tissue components

This also includes nonenhancing high-attenuation lesions that are completely

contained within the kidney and are 3 cm or larger

Category IIIIndeterminate cystic masses with thickened irregular septa with enhancement

Category IVMalignant cystic masses with all the characteristics of category III lesions

but also with enhancing soft tissue components independent of but adjacent

to the septa

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 11)

Classic findings of a simple cyst(Bosniak category 111)

Classic findings of a simple cyst(Bosniak category 1V)

Para-pelvic cyst USamp CT images

US of polycystic kidney disease

Renal infection

US of acute pyelonephritis

Acute bacterial pyelonephritis (a) US scan shows a wedge-shaped hyperechoic focus (arrowhead) in the upper pole of the right kidney related to acute bacterial pyelonephritis (b) Color flow US image demonstrates diminished flow through the involved area

US and color Doppler images of right kidney shows focal hyperechoic nephritis with decreased perfusion at the Doppler US

US and color Doppler images of kidney shows two multifocal nephritis with decreased perfusion at the Doppler US

Masslike appearance of acute bacterial pyelonephritis US and CT images

Emphysematous pyelonephritis (a) US image shows nondependent echoes within the left kidney that demonstrate a ring-down artifact (b) Corresponding CT scan helps confirm that this pattern is caused by intraparenchymal air

Xanthogranulomatous pyelonephritis (a) Contrast-enhanced CT scan demonstrates bilateral staghorn calculi with distention of the right collecting system secondary to inflammatory debris (b) US scan also shows the dilated

collecting system (arrowheads) and a shadowing calculus (arrow)

Early and mature abscess cavities (a) US scan demonstrates a geographic hypoechoic focus from an abscess in the upper pole of the right kidney (b) On a US scan of a more mature abscess the cavity is better defined with a visible pseudocapsule and through transmission that is evidenced by increased echogenicity deep to the upper pole lesion

Pyohydronephrosis

Pyohydronephrosis

Renal hydatidosis is an insidious disease and patients

often present with nonspecific clinical signs or symptoms Presenting complaints are dull flank pain hematuria palpable flank mass hypertension and renal colic

Disseminated abdominal retroperitoneal and pelvic hydatid disease (a) The right kidney is pushed to the midline and the left kidney is hydronephrotic and shrunken by retroperitoneal hydatid cysts (b) Ultrasound of the abdomen showing cystic lesions in the retroperitoneum in the position of the kidneys

Hydatid disease of the kidney US and CT images

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 13: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Longitudinal ultrasound image reveals anechoic cystic abscess With wall calcification and needle in the lesion during procedure

Benign adrenal gland tumours Adenoma Adenomas are uniformly hypoechoic with smooth margins and a round to oval shape although some lesions have scalloped borders (polycyclic) Adenomas occasionally have an inhomogeneous appearance Autopsy statistics indicate that they are quite common (10ndash20) but most adenomas (90) produce no endocrine symptoms they are bdquosilentldquo and too small to be seen with ultrasound The average size of adenomas in one study was 15 cm although they may exceed 5 cm in diameter In a small percentage of patients adenomas are bilateral Functioning and nonfunctioning adenomas are indistinguishable by their sonographic features

Medial to the upper pole of the right kidney is a sharply circumscribed hypoechoic mass typical adrenal adenoma

Hypoechoic sharply circumscribed adenoma of the right adrenal gland discovered

at routine ultrasound (confirmed by ultrasound-guided fine-needle aspiration)

Approximately 5 cm hypoechoic inhomogenous mass above the right kidney adenoma (incidentaloma) without associated symptoms detected at routine upper abdominal ultrasound Histology identified as an adrenal adenoma (most common incidentaloma)

Lipoma Myelolipoma

Lipoma A pure lipoma of the adrenal glands has

smooth margins and high homogeneous

echogenicity In contrast to the mixed tissues of

myolipoma posterior acoustic shadowing does

not occur Lipoma is rare and shows no proliferative tendency

Myelolipoma Adrenal myelolipoma has smooth margins and a homogeneous hyperechoic structure It resembles a renal angiomyolipoma in its sonographic features Posterior acoustic shadowing is often present Malignant transformation is not known to occur The tumour consists histologically of fat and bone marrow tissue (hematopoietic cells and reticular cells) Intratumoral hemorrhage and calcifications may be seen

Homogeneous sharply circumscribed hyperechoic tumour adjacent to the right kidney Classic adrenal myelolipoma

In CEUS a myelolipoma shows a nearly constant

contrast enhancement without wash out

Calcification Complete or partial calcification of the adrenal glands is characterized by a

typical echo complex with a posterior acoustic shadow Calcifications can

result from a retained intra-adrenal hemorrhage or a prior inflammatory

process (eg tuberculosis) Patients occasionally show the clinical

manifestations of Addison disease However calcifications can also develop in

tumours (carcinoma metastases Pheochromocytoma adenoma)

In the proximal left kidney in the adrenal gland region wefound a classical calcification with dorsal acoustic shadow

Small calcifications also occur in tumours of adrenal gland most often observed in pheochromocytoma

Malignant adrenal gland tumours Metastases With their rich blood supply the adrenal glands are the fourth

most frequent site for hematogenous metastasis Metastases

to the adrenal glands account for the majority of solid adrenal

tumours after the adenomas

In contrast to adenomas these lesions are less homogeneous

and often have irregular margins The most common

primaries are bronchial carcinoma (25ndash30 ) breast

carcinoma and malignant melanoma Other possible sources

are gastrointestinal urological and gynecological tumours

(renal carcinoma gastric carcinoma pancreatic carcinoma

and others) Adrenal metastases are bilateral in up to 30 of

cases and this can produce the clinical manifestations of

Addison disease Bronchial carcinoma is virtually the only

tumour that is associated with isolated adrenal metastases

(in ca 15-20 )

Large metastasis from bronchial carcinoma on the right

side with a very inhomogeneous internal structure Solid

components are seen along with central liquid areas

Transverse scan shows a metastasis with a complex echo structure ldquowedgedrdquo between right lobe of the liver inferior vena cava the kidney and spinal column

Transverse scan of a metastasis of the right adrenal gland with complex structure beside a primary tumour of lung cancer

Partial metastases esp of lung cancer show

a wash out of contrast media in late phase

US examination longitudinal view Above the right kidney in the adrenal region a solid slightly inhomogeneous mass can be seen Neuroblastoma MRI examination

axial T2 weighted image Irregular large solid inhomogeneous retroperitoneal tumor

Pheochromocytoma Pheochromocytoma is a tumour of the adrenal medulla that is generally

detected sonographically (80ndash90 of cases) following the appearance

of clinical symptoms (hypertension and tachycardia caused by

increased catecholamine secretion)

Most pheochromocytomas are already several centimeters in diameter

when diagnosed They have smooth margins a round shape and a

nonhomogeneous or complex echo structure

Hypoechoic liquid components are also observed A spectrum of

appearances may be seen Pheochromocytomas are bilateral in

approximately 10 of cases and extra-adrenal in 10ndash20

The ldquoZuckerkandl organrdquo should be looked for at the level of the origin

of the inferior mesenteric artery anterior to the aorta

Other extra-adrenal sites are the renal hilum bladder wall and thorax

Pheochromocytoma is occasionally seen posterior to the renal vein in

transverse scans Rarely pheochromocytoma is diagnosed in the

setting of multiple endocrine neoplasia (MEN) From 2 to 5 of

pheochromocytomas are malignant Owing to the risk of inciting a

hypertensive crisis fine-needle aspiration biopsy causes discrepant

discussions about FNB

Nonhomogeneous tumour with a hyperechoic center (positive endocrine test increased catecholamine secretion) ndash Pheochromocytoma

Large functionally active pheochromocytoma (7 cm in diameter) The scan shows that most of tumour is hypoechoic with some hyperechoic regions

Lymphoma The adrenal region is a rare extranodal site of occurrence for lymphoma

Foci of lymphomatous infiltration have smooth borders and are

hypoechoic Differentiation is required from lymphomas in the renal or

splenic hilum If invasion by lymphoma is suspected other nodal

stations should be scanned and commonly infiltrated organs (spleen

liver) should be closely scrutinized

Perisplenic lymphoma in the left adrenal region of a patient with B-cell lymphoma

Colour Doppler shows hypervascularisation of the lymphatic tissue

Adrenal Carcinoma Adrenal carcinoma is usually inhomogeneous hypoechoic or echo complex with irregular margins It frequently infiltrates its surroundings and metastases can be demonstrated in the adrenal region and in other organs (eg the liver) The adrenal carcinoma is a very rare (1 17 million inhabitants) highly malignant tumour with a poor prognosis Adrenal carcinoma is indistinguishable sonographically from a metastasis although the visualization of additional tumours can advance the differential diagnosis Most adrenal carcinomas are hormone-producing Sometimes one can get evidence from detection of other tumour sign The tumour is usually detected only after it has reached considerable size (often gt8 cm) Intratumoral hemorrhage necrotic foci and calcifications may occur adding to the variegated appearance

Adrenal carcinoma may be hypoechoic or may have a complex echo structure Usually it

was relatively large when diagnosed (in this case 8 cm times 9 cm) and had irregular margins

Right adrenal adenocarcinoma A Sonogram showing a complex mass with cystic changes in the right adrenal gland (arrows) B Computed tomogram showing the mass (arrows)

Incidentaloma An incidentaloma is an adrenal tumour that is detected incidentally in an asymptomatic patient Incidentalomas are found in 1 of CT examinations They are much less common in ultrasound examinations because of the difficulty in defining small lesions (lt 2 cm) The predominantly hypoechoic tumours account for the great majority of incidentalomas shows the algorithm used in the investigation of incidentalomas Approximately 10 to 15 of these tumours are hormonally active In some cases ultrasound-guided fine-needle aspiration can also aid in the evaluation of incidentalomas but only ca 1 to 2 of these tumours are malignant

Abdominal ultrasound examination incidentally found most hypoechoic lesions

smaller 2 cm without clinical symptoms ndash which is typical for incidentalomas

Histoplasmosis is a geographically restricted form of

fungal infection Adrenal involvement is seen in disseminated disease but sometimes it may be the only site of demonstrable disease Early diagnosis and treatment may save the patient from catastrophic adrenal insufficiency We present two patients showing bilateral adrenomegaly on ultrasonography and contrast-enhanced CT and was diagnosed to have histoplasmosis on fine-needle aspiration cytology

Histoplasmosis is an infective condition caused by a

dimorphic saprophytic fungus Histoplasma capsulatum and is acquired by inhalation of its spores Soil rich in bird and bat dropping is its natural habitat and it exists as a mycelium in the atmosphere

Both adrenal gland were enlarged and hypoechoic at US study

US show bilateral hypoechoic lesions and CT showed peripherally enhancing hypodense bilateral adrenals with peripheral rim and septate enhancement

ULTRASOUND OF THE ADULT KIDNEY ndash Normal

Coronal scan plane for the Right Kidney Longitudinal Normal Kidney

Scan plane transverse kidney Transverse normal image

Common anatomical variantsAtrophic small kidneyHorseshoe kidneyEctopic kidneyDuplex kidneyCross fused ectopiaUnilateral renal agenesis

COMMON PATHOLOGYCalculusRenal cyst Cortical and Para-pelvicAngiomyolipmaRenal infectionRenal cell carcinomaTransitional cell carcinomaMedullary sponge kidneyPolycystic kidney disease

Horseshoe kidney A transverse and longitudinal view across the midline showing the isthmus across the aorta

Cross fused ectopic kidney The left kidney is fused to the lower pole of the right kidney

A baggy extra-renal pelvis

Pelvic ectopic kidney

UltrasonographyOn sonograms stones are demonstrated as bright echogenic foci with posterior acoustic shadowing Stones are visualized fairly well with US in the kidneys and the distal ureter at or near the UVJ especially if dilatation is present US is good for the visualization of complications such as hydronephrosis (or other signs of obstruction) however some patients with acute obstruction have little or no dilationIn particular US is helpful in evaluating those with renal insufficiency or contraindications for the use of contrast media however US is often skipped in favor of nonenhanced CTIn addition US is good for characterizing lucent filling defects that are visualized as stones on IVU However US does not provide direct physiologic information regarding the degree of obstruction Doppler imaging may demonstrate a high resistive index in acute obstruction but this may not occur immediately or after forniceal rupture Absence of the ureteral jet as visualized with color Doppler on the symptomatic side is presumptive evidence for a high-grade obstruction in a well-hydrated patient

Degree of confidenceUS is very insensitive for stones especially stones smaller than 2 mm stones at the UPJ or stones in the mid ureter Fowler et al suggest that US has a sensitivity as low as 24 compared with nonenhanced CT Furthermore estimations of stone size may not be accurate Compared with nonenhanced CT US is more dependent on the operators ability and more time consuming

False positivesnegativesUS is fairly specific when stones are seen with a specificity as high as 90 With US matrix or indinavir stones may have soft tissue echogenicity without shadowing False-positive findings may result from renal vascular calcifications False-positive diagnoses of hydronephrosis also result from dilated vascular structures in the renal hilum Doppler imaging is helpful in distinguishing dilated vascular structures from hydronephrosis

Renal sonogram demonstrates an echogenic shadowing calculus in the renal collecting system with hydronephrosis

US images for renal stones

US images of staghorn stones

US images for ureteric stones

US images for nephrocalcinosis

Renal cystA renal cyst is a fluid collection in the kidney There are several types based on the Bosniak classification The majority are benign simple cysts that can be monitored and not intervened upon However some are cancerous or are suspicious for cancer and are commonly removed in a surgical procedure called nephrectomyNumerous renal cysts are seen in the cystic kidney diseases which include polycystic kidney diseaseand medullary sponge kidney

The Bosniak classification categorizes renal cysts into five groupsCategory I

Benign simple cyst with thin wall without septa calcifications or solid

components

It does not enhance with contrast and has a density equal to that of water

Category IIBenign cyst with a few thin septa which may contain fine calcifications or a

small

segment of mildly thickened calcification This includes homogenous

high-attenuation lesions less than 3 cm with sharp margins(Rich Kosak) but

without enhancement

Category IIFWell marginated cysts with a number of thin septa with or without mild

enhancement or thickening of septa Calcifications may be present these

may be thick and nodular There are no enhancing soft tissue components

This also includes nonenhancing high-attenuation lesions that are completely

contained within the kidney and are 3 cm or larger

Category IIIIndeterminate cystic masses with thickened irregular septa with enhancement

Category IVMalignant cystic masses with all the characteristics of category III lesions

but also with enhancing soft tissue components independent of but adjacent

to the septa

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 11)

Classic findings of a simple cyst(Bosniak category 111)

Classic findings of a simple cyst(Bosniak category 1V)

Para-pelvic cyst USamp CT images

US of polycystic kidney disease

Renal infection

US of acute pyelonephritis

Acute bacterial pyelonephritis (a) US scan shows a wedge-shaped hyperechoic focus (arrowhead) in the upper pole of the right kidney related to acute bacterial pyelonephritis (b) Color flow US image demonstrates diminished flow through the involved area

US and color Doppler images of right kidney shows focal hyperechoic nephritis with decreased perfusion at the Doppler US

US and color Doppler images of kidney shows two multifocal nephritis with decreased perfusion at the Doppler US

Masslike appearance of acute bacterial pyelonephritis US and CT images

Emphysematous pyelonephritis (a) US image shows nondependent echoes within the left kidney that demonstrate a ring-down artifact (b) Corresponding CT scan helps confirm that this pattern is caused by intraparenchymal air

Xanthogranulomatous pyelonephritis (a) Contrast-enhanced CT scan demonstrates bilateral staghorn calculi with distention of the right collecting system secondary to inflammatory debris (b) US scan also shows the dilated

collecting system (arrowheads) and a shadowing calculus (arrow)

Early and mature abscess cavities (a) US scan demonstrates a geographic hypoechoic focus from an abscess in the upper pole of the right kidney (b) On a US scan of a more mature abscess the cavity is better defined with a visible pseudocapsule and through transmission that is evidenced by increased echogenicity deep to the upper pole lesion

Pyohydronephrosis

Pyohydronephrosis

Renal hydatidosis is an insidious disease and patients

often present with nonspecific clinical signs or symptoms Presenting complaints are dull flank pain hematuria palpable flank mass hypertension and renal colic

Disseminated abdominal retroperitoneal and pelvic hydatid disease (a) The right kidney is pushed to the midline and the left kidney is hydronephrotic and shrunken by retroperitoneal hydatid cysts (b) Ultrasound of the abdomen showing cystic lesions in the retroperitoneum in the position of the kidneys

Hydatid disease of the kidney US and CT images

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 14: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Benign adrenal gland tumours Adenoma Adenomas are uniformly hypoechoic with smooth margins and a round to oval shape although some lesions have scalloped borders (polycyclic) Adenomas occasionally have an inhomogeneous appearance Autopsy statistics indicate that they are quite common (10ndash20) but most adenomas (90) produce no endocrine symptoms they are bdquosilentldquo and too small to be seen with ultrasound The average size of adenomas in one study was 15 cm although they may exceed 5 cm in diameter In a small percentage of patients adenomas are bilateral Functioning and nonfunctioning adenomas are indistinguishable by their sonographic features

Medial to the upper pole of the right kidney is a sharply circumscribed hypoechoic mass typical adrenal adenoma

Hypoechoic sharply circumscribed adenoma of the right adrenal gland discovered

at routine ultrasound (confirmed by ultrasound-guided fine-needle aspiration)

Approximately 5 cm hypoechoic inhomogenous mass above the right kidney adenoma (incidentaloma) without associated symptoms detected at routine upper abdominal ultrasound Histology identified as an adrenal adenoma (most common incidentaloma)

Lipoma Myelolipoma

Lipoma A pure lipoma of the adrenal glands has

smooth margins and high homogeneous

echogenicity In contrast to the mixed tissues of

myolipoma posterior acoustic shadowing does

not occur Lipoma is rare and shows no proliferative tendency

Myelolipoma Adrenal myelolipoma has smooth margins and a homogeneous hyperechoic structure It resembles a renal angiomyolipoma in its sonographic features Posterior acoustic shadowing is often present Malignant transformation is not known to occur The tumour consists histologically of fat and bone marrow tissue (hematopoietic cells and reticular cells) Intratumoral hemorrhage and calcifications may be seen

Homogeneous sharply circumscribed hyperechoic tumour adjacent to the right kidney Classic adrenal myelolipoma

In CEUS a myelolipoma shows a nearly constant

contrast enhancement without wash out

Calcification Complete or partial calcification of the adrenal glands is characterized by a

typical echo complex with a posterior acoustic shadow Calcifications can

result from a retained intra-adrenal hemorrhage or a prior inflammatory

process (eg tuberculosis) Patients occasionally show the clinical

manifestations of Addison disease However calcifications can also develop in

tumours (carcinoma metastases Pheochromocytoma adenoma)

In the proximal left kidney in the adrenal gland region wefound a classical calcification with dorsal acoustic shadow

Small calcifications also occur in tumours of adrenal gland most often observed in pheochromocytoma

Malignant adrenal gland tumours Metastases With their rich blood supply the adrenal glands are the fourth

most frequent site for hematogenous metastasis Metastases

to the adrenal glands account for the majority of solid adrenal

tumours after the adenomas

In contrast to adenomas these lesions are less homogeneous

and often have irregular margins The most common

primaries are bronchial carcinoma (25ndash30 ) breast

carcinoma and malignant melanoma Other possible sources

are gastrointestinal urological and gynecological tumours

(renal carcinoma gastric carcinoma pancreatic carcinoma

and others) Adrenal metastases are bilateral in up to 30 of

cases and this can produce the clinical manifestations of

Addison disease Bronchial carcinoma is virtually the only

tumour that is associated with isolated adrenal metastases

(in ca 15-20 )

Large metastasis from bronchial carcinoma on the right

side with a very inhomogeneous internal structure Solid

components are seen along with central liquid areas

Transverse scan shows a metastasis with a complex echo structure ldquowedgedrdquo between right lobe of the liver inferior vena cava the kidney and spinal column

Transverse scan of a metastasis of the right adrenal gland with complex structure beside a primary tumour of lung cancer

Partial metastases esp of lung cancer show

a wash out of contrast media in late phase

US examination longitudinal view Above the right kidney in the adrenal region a solid slightly inhomogeneous mass can be seen Neuroblastoma MRI examination

axial T2 weighted image Irregular large solid inhomogeneous retroperitoneal tumor

Pheochromocytoma Pheochromocytoma is a tumour of the adrenal medulla that is generally

detected sonographically (80ndash90 of cases) following the appearance

of clinical symptoms (hypertension and tachycardia caused by

increased catecholamine secretion)

Most pheochromocytomas are already several centimeters in diameter

when diagnosed They have smooth margins a round shape and a

nonhomogeneous or complex echo structure

Hypoechoic liquid components are also observed A spectrum of

appearances may be seen Pheochromocytomas are bilateral in

approximately 10 of cases and extra-adrenal in 10ndash20

The ldquoZuckerkandl organrdquo should be looked for at the level of the origin

of the inferior mesenteric artery anterior to the aorta

Other extra-adrenal sites are the renal hilum bladder wall and thorax

Pheochromocytoma is occasionally seen posterior to the renal vein in

transverse scans Rarely pheochromocytoma is diagnosed in the

setting of multiple endocrine neoplasia (MEN) From 2 to 5 of

pheochromocytomas are malignant Owing to the risk of inciting a

hypertensive crisis fine-needle aspiration biopsy causes discrepant

discussions about FNB

Nonhomogeneous tumour with a hyperechoic center (positive endocrine test increased catecholamine secretion) ndash Pheochromocytoma

Large functionally active pheochromocytoma (7 cm in diameter) The scan shows that most of tumour is hypoechoic with some hyperechoic regions

Lymphoma The adrenal region is a rare extranodal site of occurrence for lymphoma

Foci of lymphomatous infiltration have smooth borders and are

hypoechoic Differentiation is required from lymphomas in the renal or

splenic hilum If invasion by lymphoma is suspected other nodal

stations should be scanned and commonly infiltrated organs (spleen

liver) should be closely scrutinized

Perisplenic lymphoma in the left adrenal region of a patient with B-cell lymphoma

Colour Doppler shows hypervascularisation of the lymphatic tissue

Adrenal Carcinoma Adrenal carcinoma is usually inhomogeneous hypoechoic or echo complex with irregular margins It frequently infiltrates its surroundings and metastases can be demonstrated in the adrenal region and in other organs (eg the liver) The adrenal carcinoma is a very rare (1 17 million inhabitants) highly malignant tumour with a poor prognosis Adrenal carcinoma is indistinguishable sonographically from a metastasis although the visualization of additional tumours can advance the differential diagnosis Most adrenal carcinomas are hormone-producing Sometimes one can get evidence from detection of other tumour sign The tumour is usually detected only after it has reached considerable size (often gt8 cm) Intratumoral hemorrhage necrotic foci and calcifications may occur adding to the variegated appearance

Adrenal carcinoma may be hypoechoic or may have a complex echo structure Usually it

was relatively large when diagnosed (in this case 8 cm times 9 cm) and had irregular margins

Right adrenal adenocarcinoma A Sonogram showing a complex mass with cystic changes in the right adrenal gland (arrows) B Computed tomogram showing the mass (arrows)

Incidentaloma An incidentaloma is an adrenal tumour that is detected incidentally in an asymptomatic patient Incidentalomas are found in 1 of CT examinations They are much less common in ultrasound examinations because of the difficulty in defining small lesions (lt 2 cm) The predominantly hypoechoic tumours account for the great majority of incidentalomas shows the algorithm used in the investigation of incidentalomas Approximately 10 to 15 of these tumours are hormonally active In some cases ultrasound-guided fine-needle aspiration can also aid in the evaluation of incidentalomas but only ca 1 to 2 of these tumours are malignant

Abdominal ultrasound examination incidentally found most hypoechoic lesions

smaller 2 cm without clinical symptoms ndash which is typical for incidentalomas

Histoplasmosis is a geographically restricted form of

fungal infection Adrenal involvement is seen in disseminated disease but sometimes it may be the only site of demonstrable disease Early diagnosis and treatment may save the patient from catastrophic adrenal insufficiency We present two patients showing bilateral adrenomegaly on ultrasonography and contrast-enhanced CT and was diagnosed to have histoplasmosis on fine-needle aspiration cytology

Histoplasmosis is an infective condition caused by a

dimorphic saprophytic fungus Histoplasma capsulatum and is acquired by inhalation of its spores Soil rich in bird and bat dropping is its natural habitat and it exists as a mycelium in the atmosphere

Both adrenal gland were enlarged and hypoechoic at US study

US show bilateral hypoechoic lesions and CT showed peripherally enhancing hypodense bilateral adrenals with peripheral rim and septate enhancement

ULTRASOUND OF THE ADULT KIDNEY ndash Normal

Coronal scan plane for the Right Kidney Longitudinal Normal Kidney

Scan plane transverse kidney Transverse normal image

Common anatomical variantsAtrophic small kidneyHorseshoe kidneyEctopic kidneyDuplex kidneyCross fused ectopiaUnilateral renal agenesis

COMMON PATHOLOGYCalculusRenal cyst Cortical and Para-pelvicAngiomyolipmaRenal infectionRenal cell carcinomaTransitional cell carcinomaMedullary sponge kidneyPolycystic kidney disease

Horseshoe kidney A transverse and longitudinal view across the midline showing the isthmus across the aorta

Cross fused ectopic kidney The left kidney is fused to the lower pole of the right kidney

A baggy extra-renal pelvis

Pelvic ectopic kidney

UltrasonographyOn sonograms stones are demonstrated as bright echogenic foci with posterior acoustic shadowing Stones are visualized fairly well with US in the kidneys and the distal ureter at or near the UVJ especially if dilatation is present US is good for the visualization of complications such as hydronephrosis (or other signs of obstruction) however some patients with acute obstruction have little or no dilationIn particular US is helpful in evaluating those with renal insufficiency or contraindications for the use of contrast media however US is often skipped in favor of nonenhanced CTIn addition US is good for characterizing lucent filling defects that are visualized as stones on IVU However US does not provide direct physiologic information regarding the degree of obstruction Doppler imaging may demonstrate a high resistive index in acute obstruction but this may not occur immediately or after forniceal rupture Absence of the ureteral jet as visualized with color Doppler on the symptomatic side is presumptive evidence for a high-grade obstruction in a well-hydrated patient

Degree of confidenceUS is very insensitive for stones especially stones smaller than 2 mm stones at the UPJ or stones in the mid ureter Fowler et al suggest that US has a sensitivity as low as 24 compared with nonenhanced CT Furthermore estimations of stone size may not be accurate Compared with nonenhanced CT US is more dependent on the operators ability and more time consuming

False positivesnegativesUS is fairly specific when stones are seen with a specificity as high as 90 With US matrix or indinavir stones may have soft tissue echogenicity without shadowing False-positive findings may result from renal vascular calcifications False-positive diagnoses of hydronephrosis also result from dilated vascular structures in the renal hilum Doppler imaging is helpful in distinguishing dilated vascular structures from hydronephrosis

Renal sonogram demonstrates an echogenic shadowing calculus in the renal collecting system with hydronephrosis

US images for renal stones

US images of staghorn stones

US images for ureteric stones

US images for nephrocalcinosis

Renal cystA renal cyst is a fluid collection in the kidney There are several types based on the Bosniak classification The majority are benign simple cysts that can be monitored and not intervened upon However some are cancerous or are suspicious for cancer and are commonly removed in a surgical procedure called nephrectomyNumerous renal cysts are seen in the cystic kidney diseases which include polycystic kidney diseaseand medullary sponge kidney

The Bosniak classification categorizes renal cysts into five groupsCategory I

Benign simple cyst with thin wall without septa calcifications or solid

components

It does not enhance with contrast and has a density equal to that of water

Category IIBenign cyst with a few thin septa which may contain fine calcifications or a

small

segment of mildly thickened calcification This includes homogenous

high-attenuation lesions less than 3 cm with sharp margins(Rich Kosak) but

without enhancement

Category IIFWell marginated cysts with a number of thin septa with or without mild

enhancement or thickening of septa Calcifications may be present these

may be thick and nodular There are no enhancing soft tissue components

This also includes nonenhancing high-attenuation lesions that are completely

contained within the kidney and are 3 cm or larger

Category IIIIndeterminate cystic masses with thickened irregular septa with enhancement

Category IVMalignant cystic masses with all the characteristics of category III lesions

but also with enhancing soft tissue components independent of but adjacent

to the septa

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 11)

Classic findings of a simple cyst(Bosniak category 111)

Classic findings of a simple cyst(Bosniak category 1V)

Para-pelvic cyst USamp CT images

US of polycystic kidney disease

Renal infection

US of acute pyelonephritis

Acute bacterial pyelonephritis (a) US scan shows a wedge-shaped hyperechoic focus (arrowhead) in the upper pole of the right kidney related to acute bacterial pyelonephritis (b) Color flow US image demonstrates diminished flow through the involved area

US and color Doppler images of right kidney shows focal hyperechoic nephritis with decreased perfusion at the Doppler US

US and color Doppler images of kidney shows two multifocal nephritis with decreased perfusion at the Doppler US

Masslike appearance of acute bacterial pyelonephritis US and CT images

Emphysematous pyelonephritis (a) US image shows nondependent echoes within the left kidney that demonstrate a ring-down artifact (b) Corresponding CT scan helps confirm that this pattern is caused by intraparenchymal air

Xanthogranulomatous pyelonephritis (a) Contrast-enhanced CT scan demonstrates bilateral staghorn calculi with distention of the right collecting system secondary to inflammatory debris (b) US scan also shows the dilated

collecting system (arrowheads) and a shadowing calculus (arrow)

Early and mature abscess cavities (a) US scan demonstrates a geographic hypoechoic focus from an abscess in the upper pole of the right kidney (b) On a US scan of a more mature abscess the cavity is better defined with a visible pseudocapsule and through transmission that is evidenced by increased echogenicity deep to the upper pole lesion

Pyohydronephrosis

Pyohydronephrosis

Renal hydatidosis is an insidious disease and patients

often present with nonspecific clinical signs or symptoms Presenting complaints are dull flank pain hematuria palpable flank mass hypertension and renal colic

Disseminated abdominal retroperitoneal and pelvic hydatid disease (a) The right kidney is pushed to the midline and the left kidney is hydronephrotic and shrunken by retroperitoneal hydatid cysts (b) Ultrasound of the abdomen showing cystic lesions in the retroperitoneum in the position of the kidneys

Hydatid disease of the kidney US and CT images

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 15: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Medial to the upper pole of the right kidney is a sharply circumscribed hypoechoic mass typical adrenal adenoma

Hypoechoic sharply circumscribed adenoma of the right adrenal gland discovered

at routine ultrasound (confirmed by ultrasound-guided fine-needle aspiration)

Approximately 5 cm hypoechoic inhomogenous mass above the right kidney adenoma (incidentaloma) without associated symptoms detected at routine upper abdominal ultrasound Histology identified as an adrenal adenoma (most common incidentaloma)

Lipoma Myelolipoma

Lipoma A pure lipoma of the adrenal glands has

smooth margins and high homogeneous

echogenicity In contrast to the mixed tissues of

myolipoma posterior acoustic shadowing does

not occur Lipoma is rare and shows no proliferative tendency

Myelolipoma Adrenal myelolipoma has smooth margins and a homogeneous hyperechoic structure It resembles a renal angiomyolipoma in its sonographic features Posterior acoustic shadowing is often present Malignant transformation is not known to occur The tumour consists histologically of fat and bone marrow tissue (hematopoietic cells and reticular cells) Intratumoral hemorrhage and calcifications may be seen

Homogeneous sharply circumscribed hyperechoic tumour adjacent to the right kidney Classic adrenal myelolipoma

In CEUS a myelolipoma shows a nearly constant

contrast enhancement without wash out

Calcification Complete or partial calcification of the adrenal glands is characterized by a

typical echo complex with a posterior acoustic shadow Calcifications can

result from a retained intra-adrenal hemorrhage or a prior inflammatory

process (eg tuberculosis) Patients occasionally show the clinical

manifestations of Addison disease However calcifications can also develop in

tumours (carcinoma metastases Pheochromocytoma adenoma)

In the proximal left kidney in the adrenal gland region wefound a classical calcification with dorsal acoustic shadow

Small calcifications also occur in tumours of adrenal gland most often observed in pheochromocytoma

Malignant adrenal gland tumours Metastases With their rich blood supply the adrenal glands are the fourth

most frequent site for hematogenous metastasis Metastases

to the adrenal glands account for the majority of solid adrenal

tumours after the adenomas

In contrast to adenomas these lesions are less homogeneous

and often have irregular margins The most common

primaries are bronchial carcinoma (25ndash30 ) breast

carcinoma and malignant melanoma Other possible sources

are gastrointestinal urological and gynecological tumours

(renal carcinoma gastric carcinoma pancreatic carcinoma

and others) Adrenal metastases are bilateral in up to 30 of

cases and this can produce the clinical manifestations of

Addison disease Bronchial carcinoma is virtually the only

tumour that is associated with isolated adrenal metastases

(in ca 15-20 )

Large metastasis from bronchial carcinoma on the right

side with a very inhomogeneous internal structure Solid

components are seen along with central liquid areas

Transverse scan shows a metastasis with a complex echo structure ldquowedgedrdquo between right lobe of the liver inferior vena cava the kidney and spinal column

Transverse scan of a metastasis of the right adrenal gland with complex structure beside a primary tumour of lung cancer

Partial metastases esp of lung cancer show

a wash out of contrast media in late phase

US examination longitudinal view Above the right kidney in the adrenal region a solid slightly inhomogeneous mass can be seen Neuroblastoma MRI examination

axial T2 weighted image Irregular large solid inhomogeneous retroperitoneal tumor

Pheochromocytoma Pheochromocytoma is a tumour of the adrenal medulla that is generally

detected sonographically (80ndash90 of cases) following the appearance

of clinical symptoms (hypertension and tachycardia caused by

increased catecholamine secretion)

Most pheochromocytomas are already several centimeters in diameter

when diagnosed They have smooth margins a round shape and a

nonhomogeneous or complex echo structure

Hypoechoic liquid components are also observed A spectrum of

appearances may be seen Pheochromocytomas are bilateral in

approximately 10 of cases and extra-adrenal in 10ndash20

The ldquoZuckerkandl organrdquo should be looked for at the level of the origin

of the inferior mesenteric artery anterior to the aorta

Other extra-adrenal sites are the renal hilum bladder wall and thorax

Pheochromocytoma is occasionally seen posterior to the renal vein in

transverse scans Rarely pheochromocytoma is diagnosed in the

setting of multiple endocrine neoplasia (MEN) From 2 to 5 of

pheochromocytomas are malignant Owing to the risk of inciting a

hypertensive crisis fine-needle aspiration biopsy causes discrepant

discussions about FNB

Nonhomogeneous tumour with a hyperechoic center (positive endocrine test increased catecholamine secretion) ndash Pheochromocytoma

Large functionally active pheochromocytoma (7 cm in diameter) The scan shows that most of tumour is hypoechoic with some hyperechoic regions

Lymphoma The adrenal region is a rare extranodal site of occurrence for lymphoma

Foci of lymphomatous infiltration have smooth borders and are

hypoechoic Differentiation is required from lymphomas in the renal or

splenic hilum If invasion by lymphoma is suspected other nodal

stations should be scanned and commonly infiltrated organs (spleen

liver) should be closely scrutinized

Perisplenic lymphoma in the left adrenal region of a patient with B-cell lymphoma

Colour Doppler shows hypervascularisation of the lymphatic tissue

Adrenal Carcinoma Adrenal carcinoma is usually inhomogeneous hypoechoic or echo complex with irregular margins It frequently infiltrates its surroundings and metastases can be demonstrated in the adrenal region and in other organs (eg the liver) The adrenal carcinoma is a very rare (1 17 million inhabitants) highly malignant tumour with a poor prognosis Adrenal carcinoma is indistinguishable sonographically from a metastasis although the visualization of additional tumours can advance the differential diagnosis Most adrenal carcinomas are hormone-producing Sometimes one can get evidence from detection of other tumour sign The tumour is usually detected only after it has reached considerable size (often gt8 cm) Intratumoral hemorrhage necrotic foci and calcifications may occur adding to the variegated appearance

Adrenal carcinoma may be hypoechoic or may have a complex echo structure Usually it

was relatively large when diagnosed (in this case 8 cm times 9 cm) and had irregular margins

Right adrenal adenocarcinoma A Sonogram showing a complex mass with cystic changes in the right adrenal gland (arrows) B Computed tomogram showing the mass (arrows)

Incidentaloma An incidentaloma is an adrenal tumour that is detected incidentally in an asymptomatic patient Incidentalomas are found in 1 of CT examinations They are much less common in ultrasound examinations because of the difficulty in defining small lesions (lt 2 cm) The predominantly hypoechoic tumours account for the great majority of incidentalomas shows the algorithm used in the investigation of incidentalomas Approximately 10 to 15 of these tumours are hormonally active In some cases ultrasound-guided fine-needle aspiration can also aid in the evaluation of incidentalomas but only ca 1 to 2 of these tumours are malignant

Abdominal ultrasound examination incidentally found most hypoechoic lesions

smaller 2 cm without clinical symptoms ndash which is typical for incidentalomas

Histoplasmosis is a geographically restricted form of

fungal infection Adrenal involvement is seen in disseminated disease but sometimes it may be the only site of demonstrable disease Early diagnosis and treatment may save the patient from catastrophic adrenal insufficiency We present two patients showing bilateral adrenomegaly on ultrasonography and contrast-enhanced CT and was diagnosed to have histoplasmosis on fine-needle aspiration cytology

Histoplasmosis is an infective condition caused by a

dimorphic saprophytic fungus Histoplasma capsulatum and is acquired by inhalation of its spores Soil rich in bird and bat dropping is its natural habitat and it exists as a mycelium in the atmosphere

Both adrenal gland were enlarged and hypoechoic at US study

US show bilateral hypoechoic lesions and CT showed peripherally enhancing hypodense bilateral adrenals with peripheral rim and septate enhancement

ULTRASOUND OF THE ADULT KIDNEY ndash Normal

Coronal scan plane for the Right Kidney Longitudinal Normal Kidney

Scan plane transverse kidney Transverse normal image

Common anatomical variantsAtrophic small kidneyHorseshoe kidneyEctopic kidneyDuplex kidneyCross fused ectopiaUnilateral renal agenesis

COMMON PATHOLOGYCalculusRenal cyst Cortical and Para-pelvicAngiomyolipmaRenal infectionRenal cell carcinomaTransitional cell carcinomaMedullary sponge kidneyPolycystic kidney disease

Horseshoe kidney A transverse and longitudinal view across the midline showing the isthmus across the aorta

Cross fused ectopic kidney The left kidney is fused to the lower pole of the right kidney

A baggy extra-renal pelvis

Pelvic ectopic kidney

UltrasonographyOn sonograms stones are demonstrated as bright echogenic foci with posterior acoustic shadowing Stones are visualized fairly well with US in the kidneys and the distal ureter at or near the UVJ especially if dilatation is present US is good for the visualization of complications such as hydronephrosis (or other signs of obstruction) however some patients with acute obstruction have little or no dilationIn particular US is helpful in evaluating those with renal insufficiency or contraindications for the use of contrast media however US is often skipped in favor of nonenhanced CTIn addition US is good for characterizing lucent filling defects that are visualized as stones on IVU However US does not provide direct physiologic information regarding the degree of obstruction Doppler imaging may demonstrate a high resistive index in acute obstruction but this may not occur immediately or after forniceal rupture Absence of the ureteral jet as visualized with color Doppler on the symptomatic side is presumptive evidence for a high-grade obstruction in a well-hydrated patient

Degree of confidenceUS is very insensitive for stones especially stones smaller than 2 mm stones at the UPJ or stones in the mid ureter Fowler et al suggest that US has a sensitivity as low as 24 compared with nonenhanced CT Furthermore estimations of stone size may not be accurate Compared with nonenhanced CT US is more dependent on the operators ability and more time consuming

False positivesnegativesUS is fairly specific when stones are seen with a specificity as high as 90 With US matrix or indinavir stones may have soft tissue echogenicity without shadowing False-positive findings may result from renal vascular calcifications False-positive diagnoses of hydronephrosis also result from dilated vascular structures in the renal hilum Doppler imaging is helpful in distinguishing dilated vascular structures from hydronephrosis

Renal sonogram demonstrates an echogenic shadowing calculus in the renal collecting system with hydronephrosis

US images for renal stones

US images of staghorn stones

US images for ureteric stones

US images for nephrocalcinosis

Renal cystA renal cyst is a fluid collection in the kidney There are several types based on the Bosniak classification The majority are benign simple cysts that can be monitored and not intervened upon However some are cancerous or are suspicious for cancer and are commonly removed in a surgical procedure called nephrectomyNumerous renal cysts are seen in the cystic kidney diseases which include polycystic kidney diseaseand medullary sponge kidney

The Bosniak classification categorizes renal cysts into five groupsCategory I

Benign simple cyst with thin wall without septa calcifications or solid

components

It does not enhance with contrast and has a density equal to that of water

Category IIBenign cyst with a few thin septa which may contain fine calcifications or a

small

segment of mildly thickened calcification This includes homogenous

high-attenuation lesions less than 3 cm with sharp margins(Rich Kosak) but

without enhancement

Category IIFWell marginated cysts with a number of thin septa with or without mild

enhancement or thickening of septa Calcifications may be present these

may be thick and nodular There are no enhancing soft tissue components

This also includes nonenhancing high-attenuation lesions that are completely

contained within the kidney and are 3 cm or larger

Category IIIIndeterminate cystic masses with thickened irregular septa with enhancement

Category IVMalignant cystic masses with all the characteristics of category III lesions

but also with enhancing soft tissue components independent of but adjacent

to the septa

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 11)

Classic findings of a simple cyst(Bosniak category 111)

Classic findings of a simple cyst(Bosniak category 1V)

Para-pelvic cyst USamp CT images

US of polycystic kidney disease

Renal infection

US of acute pyelonephritis

Acute bacterial pyelonephritis (a) US scan shows a wedge-shaped hyperechoic focus (arrowhead) in the upper pole of the right kidney related to acute bacterial pyelonephritis (b) Color flow US image demonstrates diminished flow through the involved area

US and color Doppler images of right kidney shows focal hyperechoic nephritis with decreased perfusion at the Doppler US

US and color Doppler images of kidney shows two multifocal nephritis with decreased perfusion at the Doppler US

Masslike appearance of acute bacterial pyelonephritis US and CT images

Emphysematous pyelonephritis (a) US image shows nondependent echoes within the left kidney that demonstrate a ring-down artifact (b) Corresponding CT scan helps confirm that this pattern is caused by intraparenchymal air

Xanthogranulomatous pyelonephritis (a) Contrast-enhanced CT scan demonstrates bilateral staghorn calculi with distention of the right collecting system secondary to inflammatory debris (b) US scan also shows the dilated

collecting system (arrowheads) and a shadowing calculus (arrow)

Early and mature abscess cavities (a) US scan demonstrates a geographic hypoechoic focus from an abscess in the upper pole of the right kidney (b) On a US scan of a more mature abscess the cavity is better defined with a visible pseudocapsule and through transmission that is evidenced by increased echogenicity deep to the upper pole lesion

Pyohydronephrosis

Pyohydronephrosis

Renal hydatidosis is an insidious disease and patients

often present with nonspecific clinical signs or symptoms Presenting complaints are dull flank pain hematuria palpable flank mass hypertension and renal colic

Disseminated abdominal retroperitoneal and pelvic hydatid disease (a) The right kidney is pushed to the midline and the left kidney is hydronephrotic and shrunken by retroperitoneal hydatid cysts (b) Ultrasound of the abdomen showing cystic lesions in the retroperitoneum in the position of the kidneys

Hydatid disease of the kidney US and CT images

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 16: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Hypoechoic sharply circumscribed adenoma of the right adrenal gland discovered

at routine ultrasound (confirmed by ultrasound-guided fine-needle aspiration)

Approximately 5 cm hypoechoic inhomogenous mass above the right kidney adenoma (incidentaloma) without associated symptoms detected at routine upper abdominal ultrasound Histology identified as an adrenal adenoma (most common incidentaloma)

Lipoma Myelolipoma

Lipoma A pure lipoma of the adrenal glands has

smooth margins and high homogeneous

echogenicity In contrast to the mixed tissues of

myolipoma posterior acoustic shadowing does

not occur Lipoma is rare and shows no proliferative tendency

Myelolipoma Adrenal myelolipoma has smooth margins and a homogeneous hyperechoic structure It resembles a renal angiomyolipoma in its sonographic features Posterior acoustic shadowing is often present Malignant transformation is not known to occur The tumour consists histologically of fat and bone marrow tissue (hematopoietic cells and reticular cells) Intratumoral hemorrhage and calcifications may be seen

Homogeneous sharply circumscribed hyperechoic tumour adjacent to the right kidney Classic adrenal myelolipoma

In CEUS a myelolipoma shows a nearly constant

contrast enhancement without wash out

Calcification Complete or partial calcification of the adrenal glands is characterized by a

typical echo complex with a posterior acoustic shadow Calcifications can

result from a retained intra-adrenal hemorrhage or a prior inflammatory

process (eg tuberculosis) Patients occasionally show the clinical

manifestations of Addison disease However calcifications can also develop in

tumours (carcinoma metastases Pheochromocytoma adenoma)

In the proximal left kidney in the adrenal gland region wefound a classical calcification with dorsal acoustic shadow

Small calcifications also occur in tumours of adrenal gland most often observed in pheochromocytoma

Malignant adrenal gland tumours Metastases With their rich blood supply the adrenal glands are the fourth

most frequent site for hematogenous metastasis Metastases

to the adrenal glands account for the majority of solid adrenal

tumours after the adenomas

In contrast to adenomas these lesions are less homogeneous

and often have irregular margins The most common

primaries are bronchial carcinoma (25ndash30 ) breast

carcinoma and malignant melanoma Other possible sources

are gastrointestinal urological and gynecological tumours

(renal carcinoma gastric carcinoma pancreatic carcinoma

and others) Adrenal metastases are bilateral in up to 30 of

cases and this can produce the clinical manifestations of

Addison disease Bronchial carcinoma is virtually the only

tumour that is associated with isolated adrenal metastases

(in ca 15-20 )

Large metastasis from bronchial carcinoma on the right

side with a very inhomogeneous internal structure Solid

components are seen along with central liquid areas

Transverse scan shows a metastasis with a complex echo structure ldquowedgedrdquo between right lobe of the liver inferior vena cava the kidney and spinal column

Transverse scan of a metastasis of the right adrenal gland with complex structure beside a primary tumour of lung cancer

Partial metastases esp of lung cancer show

a wash out of contrast media in late phase

US examination longitudinal view Above the right kidney in the adrenal region a solid slightly inhomogeneous mass can be seen Neuroblastoma MRI examination

axial T2 weighted image Irregular large solid inhomogeneous retroperitoneal tumor

Pheochromocytoma Pheochromocytoma is a tumour of the adrenal medulla that is generally

detected sonographically (80ndash90 of cases) following the appearance

of clinical symptoms (hypertension and tachycardia caused by

increased catecholamine secretion)

Most pheochromocytomas are already several centimeters in diameter

when diagnosed They have smooth margins a round shape and a

nonhomogeneous or complex echo structure

Hypoechoic liquid components are also observed A spectrum of

appearances may be seen Pheochromocytomas are bilateral in

approximately 10 of cases and extra-adrenal in 10ndash20

The ldquoZuckerkandl organrdquo should be looked for at the level of the origin

of the inferior mesenteric artery anterior to the aorta

Other extra-adrenal sites are the renal hilum bladder wall and thorax

Pheochromocytoma is occasionally seen posterior to the renal vein in

transverse scans Rarely pheochromocytoma is diagnosed in the

setting of multiple endocrine neoplasia (MEN) From 2 to 5 of

pheochromocytomas are malignant Owing to the risk of inciting a

hypertensive crisis fine-needle aspiration biopsy causes discrepant

discussions about FNB

Nonhomogeneous tumour with a hyperechoic center (positive endocrine test increased catecholamine secretion) ndash Pheochromocytoma

Large functionally active pheochromocytoma (7 cm in diameter) The scan shows that most of tumour is hypoechoic with some hyperechoic regions

Lymphoma The adrenal region is a rare extranodal site of occurrence for lymphoma

Foci of lymphomatous infiltration have smooth borders and are

hypoechoic Differentiation is required from lymphomas in the renal or

splenic hilum If invasion by lymphoma is suspected other nodal

stations should be scanned and commonly infiltrated organs (spleen

liver) should be closely scrutinized

Perisplenic lymphoma in the left adrenal region of a patient with B-cell lymphoma

Colour Doppler shows hypervascularisation of the lymphatic tissue

Adrenal Carcinoma Adrenal carcinoma is usually inhomogeneous hypoechoic or echo complex with irregular margins It frequently infiltrates its surroundings and metastases can be demonstrated in the adrenal region and in other organs (eg the liver) The adrenal carcinoma is a very rare (1 17 million inhabitants) highly malignant tumour with a poor prognosis Adrenal carcinoma is indistinguishable sonographically from a metastasis although the visualization of additional tumours can advance the differential diagnosis Most adrenal carcinomas are hormone-producing Sometimes one can get evidence from detection of other tumour sign The tumour is usually detected only after it has reached considerable size (often gt8 cm) Intratumoral hemorrhage necrotic foci and calcifications may occur adding to the variegated appearance

Adrenal carcinoma may be hypoechoic or may have a complex echo structure Usually it

was relatively large when diagnosed (in this case 8 cm times 9 cm) and had irregular margins

Right adrenal adenocarcinoma A Sonogram showing a complex mass with cystic changes in the right adrenal gland (arrows) B Computed tomogram showing the mass (arrows)

Incidentaloma An incidentaloma is an adrenal tumour that is detected incidentally in an asymptomatic patient Incidentalomas are found in 1 of CT examinations They are much less common in ultrasound examinations because of the difficulty in defining small lesions (lt 2 cm) The predominantly hypoechoic tumours account for the great majority of incidentalomas shows the algorithm used in the investigation of incidentalomas Approximately 10 to 15 of these tumours are hormonally active In some cases ultrasound-guided fine-needle aspiration can also aid in the evaluation of incidentalomas but only ca 1 to 2 of these tumours are malignant

Abdominal ultrasound examination incidentally found most hypoechoic lesions

smaller 2 cm without clinical symptoms ndash which is typical for incidentalomas

Histoplasmosis is a geographically restricted form of

fungal infection Adrenal involvement is seen in disseminated disease but sometimes it may be the only site of demonstrable disease Early diagnosis and treatment may save the patient from catastrophic adrenal insufficiency We present two patients showing bilateral adrenomegaly on ultrasonography and contrast-enhanced CT and was diagnosed to have histoplasmosis on fine-needle aspiration cytology

Histoplasmosis is an infective condition caused by a

dimorphic saprophytic fungus Histoplasma capsulatum and is acquired by inhalation of its spores Soil rich in bird and bat dropping is its natural habitat and it exists as a mycelium in the atmosphere

Both adrenal gland were enlarged and hypoechoic at US study

US show bilateral hypoechoic lesions and CT showed peripherally enhancing hypodense bilateral adrenals with peripheral rim and septate enhancement

ULTRASOUND OF THE ADULT KIDNEY ndash Normal

Coronal scan plane for the Right Kidney Longitudinal Normal Kidney

Scan plane transverse kidney Transverse normal image

Common anatomical variantsAtrophic small kidneyHorseshoe kidneyEctopic kidneyDuplex kidneyCross fused ectopiaUnilateral renal agenesis

COMMON PATHOLOGYCalculusRenal cyst Cortical and Para-pelvicAngiomyolipmaRenal infectionRenal cell carcinomaTransitional cell carcinomaMedullary sponge kidneyPolycystic kidney disease

Horseshoe kidney A transverse and longitudinal view across the midline showing the isthmus across the aorta

Cross fused ectopic kidney The left kidney is fused to the lower pole of the right kidney

A baggy extra-renal pelvis

Pelvic ectopic kidney

UltrasonographyOn sonograms stones are demonstrated as bright echogenic foci with posterior acoustic shadowing Stones are visualized fairly well with US in the kidneys and the distal ureter at or near the UVJ especially if dilatation is present US is good for the visualization of complications such as hydronephrosis (or other signs of obstruction) however some patients with acute obstruction have little or no dilationIn particular US is helpful in evaluating those with renal insufficiency or contraindications for the use of contrast media however US is often skipped in favor of nonenhanced CTIn addition US is good for characterizing lucent filling defects that are visualized as stones on IVU However US does not provide direct physiologic information regarding the degree of obstruction Doppler imaging may demonstrate a high resistive index in acute obstruction but this may not occur immediately or after forniceal rupture Absence of the ureteral jet as visualized with color Doppler on the symptomatic side is presumptive evidence for a high-grade obstruction in a well-hydrated patient

Degree of confidenceUS is very insensitive for stones especially stones smaller than 2 mm stones at the UPJ or stones in the mid ureter Fowler et al suggest that US has a sensitivity as low as 24 compared with nonenhanced CT Furthermore estimations of stone size may not be accurate Compared with nonenhanced CT US is more dependent on the operators ability and more time consuming

False positivesnegativesUS is fairly specific when stones are seen with a specificity as high as 90 With US matrix or indinavir stones may have soft tissue echogenicity without shadowing False-positive findings may result from renal vascular calcifications False-positive diagnoses of hydronephrosis also result from dilated vascular structures in the renal hilum Doppler imaging is helpful in distinguishing dilated vascular structures from hydronephrosis

Renal sonogram demonstrates an echogenic shadowing calculus in the renal collecting system with hydronephrosis

US images for renal stones

US images of staghorn stones

US images for ureteric stones

US images for nephrocalcinosis

Renal cystA renal cyst is a fluid collection in the kidney There are several types based on the Bosniak classification The majority are benign simple cysts that can be monitored and not intervened upon However some are cancerous or are suspicious for cancer and are commonly removed in a surgical procedure called nephrectomyNumerous renal cysts are seen in the cystic kidney diseases which include polycystic kidney diseaseand medullary sponge kidney

The Bosniak classification categorizes renal cysts into five groupsCategory I

Benign simple cyst with thin wall without septa calcifications or solid

components

It does not enhance with contrast and has a density equal to that of water

Category IIBenign cyst with a few thin septa which may contain fine calcifications or a

small

segment of mildly thickened calcification This includes homogenous

high-attenuation lesions less than 3 cm with sharp margins(Rich Kosak) but

without enhancement

Category IIFWell marginated cysts with a number of thin septa with or without mild

enhancement or thickening of septa Calcifications may be present these

may be thick and nodular There are no enhancing soft tissue components

This also includes nonenhancing high-attenuation lesions that are completely

contained within the kidney and are 3 cm or larger

Category IIIIndeterminate cystic masses with thickened irregular septa with enhancement

Category IVMalignant cystic masses with all the characteristics of category III lesions

but also with enhancing soft tissue components independent of but adjacent

to the septa

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 11)

Classic findings of a simple cyst(Bosniak category 111)

Classic findings of a simple cyst(Bosniak category 1V)

Para-pelvic cyst USamp CT images

US of polycystic kidney disease

Renal infection

US of acute pyelonephritis

Acute bacterial pyelonephritis (a) US scan shows a wedge-shaped hyperechoic focus (arrowhead) in the upper pole of the right kidney related to acute bacterial pyelonephritis (b) Color flow US image demonstrates diminished flow through the involved area

US and color Doppler images of right kidney shows focal hyperechoic nephritis with decreased perfusion at the Doppler US

US and color Doppler images of kidney shows two multifocal nephritis with decreased perfusion at the Doppler US

Masslike appearance of acute bacterial pyelonephritis US and CT images

Emphysematous pyelonephritis (a) US image shows nondependent echoes within the left kidney that demonstrate a ring-down artifact (b) Corresponding CT scan helps confirm that this pattern is caused by intraparenchymal air

Xanthogranulomatous pyelonephritis (a) Contrast-enhanced CT scan demonstrates bilateral staghorn calculi with distention of the right collecting system secondary to inflammatory debris (b) US scan also shows the dilated

collecting system (arrowheads) and a shadowing calculus (arrow)

Early and mature abscess cavities (a) US scan demonstrates a geographic hypoechoic focus from an abscess in the upper pole of the right kidney (b) On a US scan of a more mature abscess the cavity is better defined with a visible pseudocapsule and through transmission that is evidenced by increased echogenicity deep to the upper pole lesion

Pyohydronephrosis

Pyohydronephrosis

Renal hydatidosis is an insidious disease and patients

often present with nonspecific clinical signs or symptoms Presenting complaints are dull flank pain hematuria palpable flank mass hypertension and renal colic

Disseminated abdominal retroperitoneal and pelvic hydatid disease (a) The right kidney is pushed to the midline and the left kidney is hydronephrotic and shrunken by retroperitoneal hydatid cysts (b) Ultrasound of the abdomen showing cystic lesions in the retroperitoneum in the position of the kidneys

Hydatid disease of the kidney US and CT images

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 17: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Approximately 5 cm hypoechoic inhomogenous mass above the right kidney adenoma (incidentaloma) without associated symptoms detected at routine upper abdominal ultrasound Histology identified as an adrenal adenoma (most common incidentaloma)

Lipoma Myelolipoma

Lipoma A pure lipoma of the adrenal glands has

smooth margins and high homogeneous

echogenicity In contrast to the mixed tissues of

myolipoma posterior acoustic shadowing does

not occur Lipoma is rare and shows no proliferative tendency

Myelolipoma Adrenal myelolipoma has smooth margins and a homogeneous hyperechoic structure It resembles a renal angiomyolipoma in its sonographic features Posterior acoustic shadowing is often present Malignant transformation is not known to occur The tumour consists histologically of fat and bone marrow tissue (hematopoietic cells and reticular cells) Intratumoral hemorrhage and calcifications may be seen

Homogeneous sharply circumscribed hyperechoic tumour adjacent to the right kidney Classic adrenal myelolipoma

In CEUS a myelolipoma shows a nearly constant

contrast enhancement without wash out

Calcification Complete or partial calcification of the adrenal glands is characterized by a

typical echo complex with a posterior acoustic shadow Calcifications can

result from a retained intra-adrenal hemorrhage or a prior inflammatory

process (eg tuberculosis) Patients occasionally show the clinical

manifestations of Addison disease However calcifications can also develop in

tumours (carcinoma metastases Pheochromocytoma adenoma)

In the proximal left kidney in the adrenal gland region wefound a classical calcification with dorsal acoustic shadow

Small calcifications also occur in tumours of adrenal gland most often observed in pheochromocytoma

Malignant adrenal gland tumours Metastases With their rich blood supply the adrenal glands are the fourth

most frequent site for hematogenous metastasis Metastases

to the adrenal glands account for the majority of solid adrenal

tumours after the adenomas

In contrast to adenomas these lesions are less homogeneous

and often have irregular margins The most common

primaries are bronchial carcinoma (25ndash30 ) breast

carcinoma and malignant melanoma Other possible sources

are gastrointestinal urological and gynecological tumours

(renal carcinoma gastric carcinoma pancreatic carcinoma

and others) Adrenal metastases are bilateral in up to 30 of

cases and this can produce the clinical manifestations of

Addison disease Bronchial carcinoma is virtually the only

tumour that is associated with isolated adrenal metastases

(in ca 15-20 )

Large metastasis from bronchial carcinoma on the right

side with a very inhomogeneous internal structure Solid

components are seen along with central liquid areas

Transverse scan shows a metastasis with a complex echo structure ldquowedgedrdquo between right lobe of the liver inferior vena cava the kidney and spinal column

Transverse scan of a metastasis of the right adrenal gland with complex structure beside a primary tumour of lung cancer

Partial metastases esp of lung cancer show

a wash out of contrast media in late phase

US examination longitudinal view Above the right kidney in the adrenal region a solid slightly inhomogeneous mass can be seen Neuroblastoma MRI examination

axial T2 weighted image Irregular large solid inhomogeneous retroperitoneal tumor

Pheochromocytoma Pheochromocytoma is a tumour of the adrenal medulla that is generally

detected sonographically (80ndash90 of cases) following the appearance

of clinical symptoms (hypertension and tachycardia caused by

increased catecholamine secretion)

Most pheochromocytomas are already several centimeters in diameter

when diagnosed They have smooth margins a round shape and a

nonhomogeneous or complex echo structure

Hypoechoic liquid components are also observed A spectrum of

appearances may be seen Pheochromocytomas are bilateral in

approximately 10 of cases and extra-adrenal in 10ndash20

The ldquoZuckerkandl organrdquo should be looked for at the level of the origin

of the inferior mesenteric artery anterior to the aorta

Other extra-adrenal sites are the renal hilum bladder wall and thorax

Pheochromocytoma is occasionally seen posterior to the renal vein in

transverse scans Rarely pheochromocytoma is diagnosed in the

setting of multiple endocrine neoplasia (MEN) From 2 to 5 of

pheochromocytomas are malignant Owing to the risk of inciting a

hypertensive crisis fine-needle aspiration biopsy causes discrepant

discussions about FNB

Nonhomogeneous tumour with a hyperechoic center (positive endocrine test increased catecholamine secretion) ndash Pheochromocytoma

Large functionally active pheochromocytoma (7 cm in diameter) The scan shows that most of tumour is hypoechoic with some hyperechoic regions

Lymphoma The adrenal region is a rare extranodal site of occurrence for lymphoma

Foci of lymphomatous infiltration have smooth borders and are

hypoechoic Differentiation is required from lymphomas in the renal or

splenic hilum If invasion by lymphoma is suspected other nodal

stations should be scanned and commonly infiltrated organs (spleen

liver) should be closely scrutinized

Perisplenic lymphoma in the left adrenal region of a patient with B-cell lymphoma

Colour Doppler shows hypervascularisation of the lymphatic tissue

Adrenal Carcinoma Adrenal carcinoma is usually inhomogeneous hypoechoic or echo complex with irregular margins It frequently infiltrates its surroundings and metastases can be demonstrated in the adrenal region and in other organs (eg the liver) The adrenal carcinoma is a very rare (1 17 million inhabitants) highly malignant tumour with a poor prognosis Adrenal carcinoma is indistinguishable sonographically from a metastasis although the visualization of additional tumours can advance the differential diagnosis Most adrenal carcinomas are hormone-producing Sometimes one can get evidence from detection of other tumour sign The tumour is usually detected only after it has reached considerable size (often gt8 cm) Intratumoral hemorrhage necrotic foci and calcifications may occur adding to the variegated appearance

Adrenal carcinoma may be hypoechoic or may have a complex echo structure Usually it

was relatively large when diagnosed (in this case 8 cm times 9 cm) and had irregular margins

Right adrenal adenocarcinoma A Sonogram showing a complex mass with cystic changes in the right adrenal gland (arrows) B Computed tomogram showing the mass (arrows)

Incidentaloma An incidentaloma is an adrenal tumour that is detected incidentally in an asymptomatic patient Incidentalomas are found in 1 of CT examinations They are much less common in ultrasound examinations because of the difficulty in defining small lesions (lt 2 cm) The predominantly hypoechoic tumours account for the great majority of incidentalomas shows the algorithm used in the investigation of incidentalomas Approximately 10 to 15 of these tumours are hormonally active In some cases ultrasound-guided fine-needle aspiration can also aid in the evaluation of incidentalomas but only ca 1 to 2 of these tumours are malignant

Abdominal ultrasound examination incidentally found most hypoechoic lesions

smaller 2 cm without clinical symptoms ndash which is typical for incidentalomas

Histoplasmosis is a geographically restricted form of

fungal infection Adrenal involvement is seen in disseminated disease but sometimes it may be the only site of demonstrable disease Early diagnosis and treatment may save the patient from catastrophic adrenal insufficiency We present two patients showing bilateral adrenomegaly on ultrasonography and contrast-enhanced CT and was diagnosed to have histoplasmosis on fine-needle aspiration cytology

Histoplasmosis is an infective condition caused by a

dimorphic saprophytic fungus Histoplasma capsulatum and is acquired by inhalation of its spores Soil rich in bird and bat dropping is its natural habitat and it exists as a mycelium in the atmosphere

Both adrenal gland were enlarged and hypoechoic at US study

US show bilateral hypoechoic lesions and CT showed peripherally enhancing hypodense bilateral adrenals with peripheral rim and septate enhancement

ULTRASOUND OF THE ADULT KIDNEY ndash Normal

Coronal scan plane for the Right Kidney Longitudinal Normal Kidney

Scan plane transverse kidney Transverse normal image

Common anatomical variantsAtrophic small kidneyHorseshoe kidneyEctopic kidneyDuplex kidneyCross fused ectopiaUnilateral renal agenesis

COMMON PATHOLOGYCalculusRenal cyst Cortical and Para-pelvicAngiomyolipmaRenal infectionRenal cell carcinomaTransitional cell carcinomaMedullary sponge kidneyPolycystic kidney disease

Horseshoe kidney A transverse and longitudinal view across the midline showing the isthmus across the aorta

Cross fused ectopic kidney The left kidney is fused to the lower pole of the right kidney

A baggy extra-renal pelvis

Pelvic ectopic kidney

UltrasonographyOn sonograms stones are demonstrated as bright echogenic foci with posterior acoustic shadowing Stones are visualized fairly well with US in the kidneys and the distal ureter at or near the UVJ especially if dilatation is present US is good for the visualization of complications such as hydronephrosis (or other signs of obstruction) however some patients with acute obstruction have little or no dilationIn particular US is helpful in evaluating those with renal insufficiency or contraindications for the use of contrast media however US is often skipped in favor of nonenhanced CTIn addition US is good for characterizing lucent filling defects that are visualized as stones on IVU However US does not provide direct physiologic information regarding the degree of obstruction Doppler imaging may demonstrate a high resistive index in acute obstruction but this may not occur immediately or after forniceal rupture Absence of the ureteral jet as visualized with color Doppler on the symptomatic side is presumptive evidence for a high-grade obstruction in a well-hydrated patient

Degree of confidenceUS is very insensitive for stones especially stones smaller than 2 mm stones at the UPJ or stones in the mid ureter Fowler et al suggest that US has a sensitivity as low as 24 compared with nonenhanced CT Furthermore estimations of stone size may not be accurate Compared with nonenhanced CT US is more dependent on the operators ability and more time consuming

False positivesnegativesUS is fairly specific when stones are seen with a specificity as high as 90 With US matrix or indinavir stones may have soft tissue echogenicity without shadowing False-positive findings may result from renal vascular calcifications False-positive diagnoses of hydronephrosis also result from dilated vascular structures in the renal hilum Doppler imaging is helpful in distinguishing dilated vascular structures from hydronephrosis

Renal sonogram demonstrates an echogenic shadowing calculus in the renal collecting system with hydronephrosis

US images for renal stones

US images of staghorn stones

US images for ureteric stones

US images for nephrocalcinosis

Renal cystA renal cyst is a fluid collection in the kidney There are several types based on the Bosniak classification The majority are benign simple cysts that can be monitored and not intervened upon However some are cancerous or are suspicious for cancer and are commonly removed in a surgical procedure called nephrectomyNumerous renal cysts are seen in the cystic kidney diseases which include polycystic kidney diseaseand medullary sponge kidney

The Bosniak classification categorizes renal cysts into five groupsCategory I

Benign simple cyst with thin wall without septa calcifications or solid

components

It does not enhance with contrast and has a density equal to that of water

Category IIBenign cyst with a few thin septa which may contain fine calcifications or a

small

segment of mildly thickened calcification This includes homogenous

high-attenuation lesions less than 3 cm with sharp margins(Rich Kosak) but

without enhancement

Category IIFWell marginated cysts with a number of thin septa with or without mild

enhancement or thickening of septa Calcifications may be present these

may be thick and nodular There are no enhancing soft tissue components

This also includes nonenhancing high-attenuation lesions that are completely

contained within the kidney and are 3 cm or larger

Category IIIIndeterminate cystic masses with thickened irregular septa with enhancement

Category IVMalignant cystic masses with all the characteristics of category III lesions

but also with enhancing soft tissue components independent of but adjacent

to the septa

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 11)

Classic findings of a simple cyst(Bosniak category 111)

Classic findings of a simple cyst(Bosniak category 1V)

Para-pelvic cyst USamp CT images

US of polycystic kidney disease

Renal infection

US of acute pyelonephritis

Acute bacterial pyelonephritis (a) US scan shows a wedge-shaped hyperechoic focus (arrowhead) in the upper pole of the right kidney related to acute bacterial pyelonephritis (b) Color flow US image demonstrates diminished flow through the involved area

US and color Doppler images of right kidney shows focal hyperechoic nephritis with decreased perfusion at the Doppler US

US and color Doppler images of kidney shows two multifocal nephritis with decreased perfusion at the Doppler US

Masslike appearance of acute bacterial pyelonephritis US and CT images

Emphysematous pyelonephritis (a) US image shows nondependent echoes within the left kidney that demonstrate a ring-down artifact (b) Corresponding CT scan helps confirm that this pattern is caused by intraparenchymal air

Xanthogranulomatous pyelonephritis (a) Contrast-enhanced CT scan demonstrates bilateral staghorn calculi with distention of the right collecting system secondary to inflammatory debris (b) US scan also shows the dilated

collecting system (arrowheads) and a shadowing calculus (arrow)

Early and mature abscess cavities (a) US scan demonstrates a geographic hypoechoic focus from an abscess in the upper pole of the right kidney (b) On a US scan of a more mature abscess the cavity is better defined with a visible pseudocapsule and through transmission that is evidenced by increased echogenicity deep to the upper pole lesion

Pyohydronephrosis

Pyohydronephrosis

Renal hydatidosis is an insidious disease and patients

often present with nonspecific clinical signs or symptoms Presenting complaints are dull flank pain hematuria palpable flank mass hypertension and renal colic

Disseminated abdominal retroperitoneal and pelvic hydatid disease (a) The right kidney is pushed to the midline and the left kidney is hydronephrotic and shrunken by retroperitoneal hydatid cysts (b) Ultrasound of the abdomen showing cystic lesions in the retroperitoneum in the position of the kidneys

Hydatid disease of the kidney US and CT images

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 18: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Lipoma Myelolipoma

Lipoma A pure lipoma of the adrenal glands has

smooth margins and high homogeneous

echogenicity In contrast to the mixed tissues of

myolipoma posterior acoustic shadowing does

not occur Lipoma is rare and shows no proliferative tendency

Myelolipoma Adrenal myelolipoma has smooth margins and a homogeneous hyperechoic structure It resembles a renal angiomyolipoma in its sonographic features Posterior acoustic shadowing is often present Malignant transformation is not known to occur The tumour consists histologically of fat and bone marrow tissue (hematopoietic cells and reticular cells) Intratumoral hemorrhage and calcifications may be seen

Homogeneous sharply circumscribed hyperechoic tumour adjacent to the right kidney Classic adrenal myelolipoma

In CEUS a myelolipoma shows a nearly constant

contrast enhancement without wash out

Calcification Complete or partial calcification of the adrenal glands is characterized by a

typical echo complex with a posterior acoustic shadow Calcifications can

result from a retained intra-adrenal hemorrhage or a prior inflammatory

process (eg tuberculosis) Patients occasionally show the clinical

manifestations of Addison disease However calcifications can also develop in

tumours (carcinoma metastases Pheochromocytoma adenoma)

In the proximal left kidney in the adrenal gland region wefound a classical calcification with dorsal acoustic shadow

Small calcifications also occur in tumours of adrenal gland most often observed in pheochromocytoma

Malignant adrenal gland tumours Metastases With their rich blood supply the adrenal glands are the fourth

most frequent site for hematogenous metastasis Metastases

to the adrenal glands account for the majority of solid adrenal

tumours after the adenomas

In contrast to adenomas these lesions are less homogeneous

and often have irregular margins The most common

primaries are bronchial carcinoma (25ndash30 ) breast

carcinoma and malignant melanoma Other possible sources

are gastrointestinal urological and gynecological tumours

(renal carcinoma gastric carcinoma pancreatic carcinoma

and others) Adrenal metastases are bilateral in up to 30 of

cases and this can produce the clinical manifestations of

Addison disease Bronchial carcinoma is virtually the only

tumour that is associated with isolated adrenal metastases

(in ca 15-20 )

Large metastasis from bronchial carcinoma on the right

side with a very inhomogeneous internal structure Solid

components are seen along with central liquid areas

Transverse scan shows a metastasis with a complex echo structure ldquowedgedrdquo between right lobe of the liver inferior vena cava the kidney and spinal column

Transverse scan of a metastasis of the right adrenal gland with complex structure beside a primary tumour of lung cancer

Partial metastases esp of lung cancer show

a wash out of contrast media in late phase

US examination longitudinal view Above the right kidney in the adrenal region a solid slightly inhomogeneous mass can be seen Neuroblastoma MRI examination

axial T2 weighted image Irregular large solid inhomogeneous retroperitoneal tumor

Pheochromocytoma Pheochromocytoma is a tumour of the adrenal medulla that is generally

detected sonographically (80ndash90 of cases) following the appearance

of clinical symptoms (hypertension and tachycardia caused by

increased catecholamine secretion)

Most pheochromocytomas are already several centimeters in diameter

when diagnosed They have smooth margins a round shape and a

nonhomogeneous or complex echo structure

Hypoechoic liquid components are also observed A spectrum of

appearances may be seen Pheochromocytomas are bilateral in

approximately 10 of cases and extra-adrenal in 10ndash20

The ldquoZuckerkandl organrdquo should be looked for at the level of the origin

of the inferior mesenteric artery anterior to the aorta

Other extra-adrenal sites are the renal hilum bladder wall and thorax

Pheochromocytoma is occasionally seen posterior to the renal vein in

transverse scans Rarely pheochromocytoma is diagnosed in the

setting of multiple endocrine neoplasia (MEN) From 2 to 5 of

pheochromocytomas are malignant Owing to the risk of inciting a

hypertensive crisis fine-needle aspiration biopsy causes discrepant

discussions about FNB

Nonhomogeneous tumour with a hyperechoic center (positive endocrine test increased catecholamine secretion) ndash Pheochromocytoma

Large functionally active pheochromocytoma (7 cm in diameter) The scan shows that most of tumour is hypoechoic with some hyperechoic regions

Lymphoma The adrenal region is a rare extranodal site of occurrence for lymphoma

Foci of lymphomatous infiltration have smooth borders and are

hypoechoic Differentiation is required from lymphomas in the renal or

splenic hilum If invasion by lymphoma is suspected other nodal

stations should be scanned and commonly infiltrated organs (spleen

liver) should be closely scrutinized

Perisplenic lymphoma in the left adrenal region of a patient with B-cell lymphoma

Colour Doppler shows hypervascularisation of the lymphatic tissue

Adrenal Carcinoma Adrenal carcinoma is usually inhomogeneous hypoechoic or echo complex with irregular margins It frequently infiltrates its surroundings and metastases can be demonstrated in the adrenal region and in other organs (eg the liver) The adrenal carcinoma is a very rare (1 17 million inhabitants) highly malignant tumour with a poor prognosis Adrenal carcinoma is indistinguishable sonographically from a metastasis although the visualization of additional tumours can advance the differential diagnosis Most adrenal carcinomas are hormone-producing Sometimes one can get evidence from detection of other tumour sign The tumour is usually detected only after it has reached considerable size (often gt8 cm) Intratumoral hemorrhage necrotic foci and calcifications may occur adding to the variegated appearance

Adrenal carcinoma may be hypoechoic or may have a complex echo structure Usually it

was relatively large when diagnosed (in this case 8 cm times 9 cm) and had irregular margins

Right adrenal adenocarcinoma A Sonogram showing a complex mass with cystic changes in the right adrenal gland (arrows) B Computed tomogram showing the mass (arrows)

Incidentaloma An incidentaloma is an adrenal tumour that is detected incidentally in an asymptomatic patient Incidentalomas are found in 1 of CT examinations They are much less common in ultrasound examinations because of the difficulty in defining small lesions (lt 2 cm) The predominantly hypoechoic tumours account for the great majority of incidentalomas shows the algorithm used in the investigation of incidentalomas Approximately 10 to 15 of these tumours are hormonally active In some cases ultrasound-guided fine-needle aspiration can also aid in the evaluation of incidentalomas but only ca 1 to 2 of these tumours are malignant

Abdominal ultrasound examination incidentally found most hypoechoic lesions

smaller 2 cm without clinical symptoms ndash which is typical for incidentalomas

Histoplasmosis is a geographically restricted form of

fungal infection Adrenal involvement is seen in disseminated disease but sometimes it may be the only site of demonstrable disease Early diagnosis and treatment may save the patient from catastrophic adrenal insufficiency We present two patients showing bilateral adrenomegaly on ultrasonography and contrast-enhanced CT and was diagnosed to have histoplasmosis on fine-needle aspiration cytology

Histoplasmosis is an infective condition caused by a

dimorphic saprophytic fungus Histoplasma capsulatum and is acquired by inhalation of its spores Soil rich in bird and bat dropping is its natural habitat and it exists as a mycelium in the atmosphere

Both adrenal gland were enlarged and hypoechoic at US study

US show bilateral hypoechoic lesions and CT showed peripherally enhancing hypodense bilateral adrenals with peripheral rim and septate enhancement

ULTRASOUND OF THE ADULT KIDNEY ndash Normal

Coronal scan plane for the Right Kidney Longitudinal Normal Kidney

Scan plane transverse kidney Transverse normal image

Common anatomical variantsAtrophic small kidneyHorseshoe kidneyEctopic kidneyDuplex kidneyCross fused ectopiaUnilateral renal agenesis

COMMON PATHOLOGYCalculusRenal cyst Cortical and Para-pelvicAngiomyolipmaRenal infectionRenal cell carcinomaTransitional cell carcinomaMedullary sponge kidneyPolycystic kidney disease

Horseshoe kidney A transverse and longitudinal view across the midline showing the isthmus across the aorta

Cross fused ectopic kidney The left kidney is fused to the lower pole of the right kidney

A baggy extra-renal pelvis

Pelvic ectopic kidney

UltrasonographyOn sonograms stones are demonstrated as bright echogenic foci with posterior acoustic shadowing Stones are visualized fairly well with US in the kidneys and the distal ureter at or near the UVJ especially if dilatation is present US is good for the visualization of complications such as hydronephrosis (or other signs of obstruction) however some patients with acute obstruction have little or no dilationIn particular US is helpful in evaluating those with renal insufficiency or contraindications for the use of contrast media however US is often skipped in favor of nonenhanced CTIn addition US is good for characterizing lucent filling defects that are visualized as stones on IVU However US does not provide direct physiologic information regarding the degree of obstruction Doppler imaging may demonstrate a high resistive index in acute obstruction but this may not occur immediately or after forniceal rupture Absence of the ureteral jet as visualized with color Doppler on the symptomatic side is presumptive evidence for a high-grade obstruction in a well-hydrated patient

Degree of confidenceUS is very insensitive for stones especially stones smaller than 2 mm stones at the UPJ or stones in the mid ureter Fowler et al suggest that US has a sensitivity as low as 24 compared with nonenhanced CT Furthermore estimations of stone size may not be accurate Compared with nonenhanced CT US is more dependent on the operators ability and more time consuming

False positivesnegativesUS is fairly specific when stones are seen with a specificity as high as 90 With US matrix or indinavir stones may have soft tissue echogenicity without shadowing False-positive findings may result from renal vascular calcifications False-positive diagnoses of hydronephrosis also result from dilated vascular structures in the renal hilum Doppler imaging is helpful in distinguishing dilated vascular structures from hydronephrosis

Renal sonogram demonstrates an echogenic shadowing calculus in the renal collecting system with hydronephrosis

US images for renal stones

US images of staghorn stones

US images for ureteric stones

US images for nephrocalcinosis

Renal cystA renal cyst is a fluid collection in the kidney There are several types based on the Bosniak classification The majority are benign simple cysts that can be monitored and not intervened upon However some are cancerous or are suspicious for cancer and are commonly removed in a surgical procedure called nephrectomyNumerous renal cysts are seen in the cystic kidney diseases which include polycystic kidney diseaseand medullary sponge kidney

The Bosniak classification categorizes renal cysts into five groupsCategory I

Benign simple cyst with thin wall without septa calcifications or solid

components

It does not enhance with contrast and has a density equal to that of water

Category IIBenign cyst with a few thin septa which may contain fine calcifications or a

small

segment of mildly thickened calcification This includes homogenous

high-attenuation lesions less than 3 cm with sharp margins(Rich Kosak) but

without enhancement

Category IIFWell marginated cysts with a number of thin septa with or without mild

enhancement or thickening of septa Calcifications may be present these

may be thick and nodular There are no enhancing soft tissue components

This also includes nonenhancing high-attenuation lesions that are completely

contained within the kidney and are 3 cm or larger

Category IIIIndeterminate cystic masses with thickened irregular septa with enhancement

Category IVMalignant cystic masses with all the characteristics of category III lesions

but also with enhancing soft tissue components independent of but adjacent

to the septa

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 11)

Classic findings of a simple cyst(Bosniak category 111)

Classic findings of a simple cyst(Bosniak category 1V)

Para-pelvic cyst USamp CT images

US of polycystic kidney disease

Renal infection

US of acute pyelonephritis

Acute bacterial pyelonephritis (a) US scan shows a wedge-shaped hyperechoic focus (arrowhead) in the upper pole of the right kidney related to acute bacterial pyelonephritis (b) Color flow US image demonstrates diminished flow through the involved area

US and color Doppler images of right kidney shows focal hyperechoic nephritis with decreased perfusion at the Doppler US

US and color Doppler images of kidney shows two multifocal nephritis with decreased perfusion at the Doppler US

Masslike appearance of acute bacterial pyelonephritis US and CT images

Emphysematous pyelonephritis (a) US image shows nondependent echoes within the left kidney that demonstrate a ring-down artifact (b) Corresponding CT scan helps confirm that this pattern is caused by intraparenchymal air

Xanthogranulomatous pyelonephritis (a) Contrast-enhanced CT scan demonstrates bilateral staghorn calculi with distention of the right collecting system secondary to inflammatory debris (b) US scan also shows the dilated

collecting system (arrowheads) and a shadowing calculus (arrow)

Early and mature abscess cavities (a) US scan demonstrates a geographic hypoechoic focus from an abscess in the upper pole of the right kidney (b) On a US scan of a more mature abscess the cavity is better defined with a visible pseudocapsule and through transmission that is evidenced by increased echogenicity deep to the upper pole lesion

Pyohydronephrosis

Pyohydronephrosis

Renal hydatidosis is an insidious disease and patients

often present with nonspecific clinical signs or symptoms Presenting complaints are dull flank pain hematuria palpable flank mass hypertension and renal colic

Disseminated abdominal retroperitoneal and pelvic hydatid disease (a) The right kidney is pushed to the midline and the left kidney is hydronephrotic and shrunken by retroperitoneal hydatid cysts (b) Ultrasound of the abdomen showing cystic lesions in the retroperitoneum in the position of the kidneys

Hydatid disease of the kidney US and CT images

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 19: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Homogeneous sharply circumscribed hyperechoic tumour adjacent to the right kidney Classic adrenal myelolipoma

In CEUS a myelolipoma shows a nearly constant

contrast enhancement without wash out

Calcification Complete or partial calcification of the adrenal glands is characterized by a

typical echo complex with a posterior acoustic shadow Calcifications can

result from a retained intra-adrenal hemorrhage or a prior inflammatory

process (eg tuberculosis) Patients occasionally show the clinical

manifestations of Addison disease However calcifications can also develop in

tumours (carcinoma metastases Pheochromocytoma adenoma)

In the proximal left kidney in the adrenal gland region wefound a classical calcification with dorsal acoustic shadow

Small calcifications also occur in tumours of adrenal gland most often observed in pheochromocytoma

Malignant adrenal gland tumours Metastases With their rich blood supply the adrenal glands are the fourth

most frequent site for hematogenous metastasis Metastases

to the adrenal glands account for the majority of solid adrenal

tumours after the adenomas

In contrast to adenomas these lesions are less homogeneous

and often have irregular margins The most common

primaries are bronchial carcinoma (25ndash30 ) breast

carcinoma and malignant melanoma Other possible sources

are gastrointestinal urological and gynecological tumours

(renal carcinoma gastric carcinoma pancreatic carcinoma

and others) Adrenal metastases are bilateral in up to 30 of

cases and this can produce the clinical manifestations of

Addison disease Bronchial carcinoma is virtually the only

tumour that is associated with isolated adrenal metastases

(in ca 15-20 )

Large metastasis from bronchial carcinoma on the right

side with a very inhomogeneous internal structure Solid

components are seen along with central liquid areas

Transverse scan shows a metastasis with a complex echo structure ldquowedgedrdquo between right lobe of the liver inferior vena cava the kidney and spinal column

Transverse scan of a metastasis of the right adrenal gland with complex structure beside a primary tumour of lung cancer

Partial metastases esp of lung cancer show

a wash out of contrast media in late phase

US examination longitudinal view Above the right kidney in the adrenal region a solid slightly inhomogeneous mass can be seen Neuroblastoma MRI examination

axial T2 weighted image Irregular large solid inhomogeneous retroperitoneal tumor

Pheochromocytoma Pheochromocytoma is a tumour of the adrenal medulla that is generally

detected sonographically (80ndash90 of cases) following the appearance

of clinical symptoms (hypertension and tachycardia caused by

increased catecholamine secretion)

Most pheochromocytomas are already several centimeters in diameter

when diagnosed They have smooth margins a round shape and a

nonhomogeneous or complex echo structure

Hypoechoic liquid components are also observed A spectrum of

appearances may be seen Pheochromocytomas are bilateral in

approximately 10 of cases and extra-adrenal in 10ndash20

The ldquoZuckerkandl organrdquo should be looked for at the level of the origin

of the inferior mesenteric artery anterior to the aorta

Other extra-adrenal sites are the renal hilum bladder wall and thorax

Pheochromocytoma is occasionally seen posterior to the renal vein in

transverse scans Rarely pheochromocytoma is diagnosed in the

setting of multiple endocrine neoplasia (MEN) From 2 to 5 of

pheochromocytomas are malignant Owing to the risk of inciting a

hypertensive crisis fine-needle aspiration biopsy causes discrepant

discussions about FNB

Nonhomogeneous tumour with a hyperechoic center (positive endocrine test increased catecholamine secretion) ndash Pheochromocytoma

Large functionally active pheochromocytoma (7 cm in diameter) The scan shows that most of tumour is hypoechoic with some hyperechoic regions

Lymphoma The adrenal region is a rare extranodal site of occurrence for lymphoma

Foci of lymphomatous infiltration have smooth borders and are

hypoechoic Differentiation is required from lymphomas in the renal or

splenic hilum If invasion by lymphoma is suspected other nodal

stations should be scanned and commonly infiltrated organs (spleen

liver) should be closely scrutinized

Perisplenic lymphoma in the left adrenal region of a patient with B-cell lymphoma

Colour Doppler shows hypervascularisation of the lymphatic tissue

Adrenal Carcinoma Adrenal carcinoma is usually inhomogeneous hypoechoic or echo complex with irregular margins It frequently infiltrates its surroundings and metastases can be demonstrated in the adrenal region and in other organs (eg the liver) The adrenal carcinoma is a very rare (1 17 million inhabitants) highly malignant tumour with a poor prognosis Adrenal carcinoma is indistinguishable sonographically from a metastasis although the visualization of additional tumours can advance the differential diagnosis Most adrenal carcinomas are hormone-producing Sometimes one can get evidence from detection of other tumour sign The tumour is usually detected only after it has reached considerable size (often gt8 cm) Intratumoral hemorrhage necrotic foci and calcifications may occur adding to the variegated appearance

Adrenal carcinoma may be hypoechoic or may have a complex echo structure Usually it

was relatively large when diagnosed (in this case 8 cm times 9 cm) and had irregular margins

Right adrenal adenocarcinoma A Sonogram showing a complex mass with cystic changes in the right adrenal gland (arrows) B Computed tomogram showing the mass (arrows)

Incidentaloma An incidentaloma is an adrenal tumour that is detected incidentally in an asymptomatic patient Incidentalomas are found in 1 of CT examinations They are much less common in ultrasound examinations because of the difficulty in defining small lesions (lt 2 cm) The predominantly hypoechoic tumours account for the great majority of incidentalomas shows the algorithm used in the investigation of incidentalomas Approximately 10 to 15 of these tumours are hormonally active In some cases ultrasound-guided fine-needle aspiration can also aid in the evaluation of incidentalomas but only ca 1 to 2 of these tumours are malignant

Abdominal ultrasound examination incidentally found most hypoechoic lesions

smaller 2 cm without clinical symptoms ndash which is typical for incidentalomas

Histoplasmosis is a geographically restricted form of

fungal infection Adrenal involvement is seen in disseminated disease but sometimes it may be the only site of demonstrable disease Early diagnosis and treatment may save the patient from catastrophic adrenal insufficiency We present two patients showing bilateral adrenomegaly on ultrasonography and contrast-enhanced CT and was diagnosed to have histoplasmosis on fine-needle aspiration cytology

Histoplasmosis is an infective condition caused by a

dimorphic saprophytic fungus Histoplasma capsulatum and is acquired by inhalation of its spores Soil rich in bird and bat dropping is its natural habitat and it exists as a mycelium in the atmosphere

Both adrenal gland were enlarged and hypoechoic at US study

US show bilateral hypoechoic lesions and CT showed peripherally enhancing hypodense bilateral adrenals with peripheral rim and septate enhancement

ULTRASOUND OF THE ADULT KIDNEY ndash Normal

Coronal scan plane for the Right Kidney Longitudinal Normal Kidney

Scan plane transverse kidney Transverse normal image

Common anatomical variantsAtrophic small kidneyHorseshoe kidneyEctopic kidneyDuplex kidneyCross fused ectopiaUnilateral renal agenesis

COMMON PATHOLOGYCalculusRenal cyst Cortical and Para-pelvicAngiomyolipmaRenal infectionRenal cell carcinomaTransitional cell carcinomaMedullary sponge kidneyPolycystic kidney disease

Horseshoe kidney A transverse and longitudinal view across the midline showing the isthmus across the aorta

Cross fused ectopic kidney The left kidney is fused to the lower pole of the right kidney

A baggy extra-renal pelvis

Pelvic ectopic kidney

UltrasonographyOn sonograms stones are demonstrated as bright echogenic foci with posterior acoustic shadowing Stones are visualized fairly well with US in the kidneys and the distal ureter at or near the UVJ especially if dilatation is present US is good for the visualization of complications such as hydronephrosis (or other signs of obstruction) however some patients with acute obstruction have little or no dilationIn particular US is helpful in evaluating those with renal insufficiency or contraindications for the use of contrast media however US is often skipped in favor of nonenhanced CTIn addition US is good for characterizing lucent filling defects that are visualized as stones on IVU However US does not provide direct physiologic information regarding the degree of obstruction Doppler imaging may demonstrate a high resistive index in acute obstruction but this may not occur immediately or after forniceal rupture Absence of the ureteral jet as visualized with color Doppler on the symptomatic side is presumptive evidence for a high-grade obstruction in a well-hydrated patient

Degree of confidenceUS is very insensitive for stones especially stones smaller than 2 mm stones at the UPJ or stones in the mid ureter Fowler et al suggest that US has a sensitivity as low as 24 compared with nonenhanced CT Furthermore estimations of stone size may not be accurate Compared with nonenhanced CT US is more dependent on the operators ability and more time consuming

False positivesnegativesUS is fairly specific when stones are seen with a specificity as high as 90 With US matrix or indinavir stones may have soft tissue echogenicity without shadowing False-positive findings may result from renal vascular calcifications False-positive diagnoses of hydronephrosis also result from dilated vascular structures in the renal hilum Doppler imaging is helpful in distinguishing dilated vascular structures from hydronephrosis

Renal sonogram demonstrates an echogenic shadowing calculus in the renal collecting system with hydronephrosis

US images for renal stones

US images of staghorn stones

US images for ureteric stones

US images for nephrocalcinosis

Renal cystA renal cyst is a fluid collection in the kidney There are several types based on the Bosniak classification The majority are benign simple cysts that can be monitored and not intervened upon However some are cancerous or are suspicious for cancer and are commonly removed in a surgical procedure called nephrectomyNumerous renal cysts are seen in the cystic kidney diseases which include polycystic kidney diseaseand medullary sponge kidney

The Bosniak classification categorizes renal cysts into five groupsCategory I

Benign simple cyst with thin wall without septa calcifications or solid

components

It does not enhance with contrast and has a density equal to that of water

Category IIBenign cyst with a few thin septa which may contain fine calcifications or a

small

segment of mildly thickened calcification This includes homogenous

high-attenuation lesions less than 3 cm with sharp margins(Rich Kosak) but

without enhancement

Category IIFWell marginated cysts with a number of thin septa with or without mild

enhancement or thickening of septa Calcifications may be present these

may be thick and nodular There are no enhancing soft tissue components

This also includes nonenhancing high-attenuation lesions that are completely

contained within the kidney and are 3 cm or larger

Category IIIIndeterminate cystic masses with thickened irregular septa with enhancement

Category IVMalignant cystic masses with all the characteristics of category III lesions

but also with enhancing soft tissue components independent of but adjacent

to the septa

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 11)

Classic findings of a simple cyst(Bosniak category 111)

Classic findings of a simple cyst(Bosniak category 1V)

Para-pelvic cyst USamp CT images

US of polycystic kidney disease

Renal infection

US of acute pyelonephritis

Acute bacterial pyelonephritis (a) US scan shows a wedge-shaped hyperechoic focus (arrowhead) in the upper pole of the right kidney related to acute bacterial pyelonephritis (b) Color flow US image demonstrates diminished flow through the involved area

US and color Doppler images of right kidney shows focal hyperechoic nephritis with decreased perfusion at the Doppler US

US and color Doppler images of kidney shows two multifocal nephritis with decreased perfusion at the Doppler US

Masslike appearance of acute bacterial pyelonephritis US and CT images

Emphysematous pyelonephritis (a) US image shows nondependent echoes within the left kidney that demonstrate a ring-down artifact (b) Corresponding CT scan helps confirm that this pattern is caused by intraparenchymal air

Xanthogranulomatous pyelonephritis (a) Contrast-enhanced CT scan demonstrates bilateral staghorn calculi with distention of the right collecting system secondary to inflammatory debris (b) US scan also shows the dilated

collecting system (arrowheads) and a shadowing calculus (arrow)

Early and mature abscess cavities (a) US scan demonstrates a geographic hypoechoic focus from an abscess in the upper pole of the right kidney (b) On a US scan of a more mature abscess the cavity is better defined with a visible pseudocapsule and through transmission that is evidenced by increased echogenicity deep to the upper pole lesion

Pyohydronephrosis

Pyohydronephrosis

Renal hydatidosis is an insidious disease and patients

often present with nonspecific clinical signs or symptoms Presenting complaints are dull flank pain hematuria palpable flank mass hypertension and renal colic

Disseminated abdominal retroperitoneal and pelvic hydatid disease (a) The right kidney is pushed to the midline and the left kidney is hydronephrotic and shrunken by retroperitoneal hydatid cysts (b) Ultrasound of the abdomen showing cystic lesions in the retroperitoneum in the position of the kidneys

Hydatid disease of the kidney US and CT images

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 20: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

In CEUS a myelolipoma shows a nearly constant

contrast enhancement without wash out

Calcification Complete or partial calcification of the adrenal glands is characterized by a

typical echo complex with a posterior acoustic shadow Calcifications can

result from a retained intra-adrenal hemorrhage or a prior inflammatory

process (eg tuberculosis) Patients occasionally show the clinical

manifestations of Addison disease However calcifications can also develop in

tumours (carcinoma metastases Pheochromocytoma adenoma)

In the proximal left kidney in the adrenal gland region wefound a classical calcification with dorsal acoustic shadow

Small calcifications also occur in tumours of adrenal gland most often observed in pheochromocytoma

Malignant adrenal gland tumours Metastases With their rich blood supply the adrenal glands are the fourth

most frequent site for hematogenous metastasis Metastases

to the adrenal glands account for the majority of solid adrenal

tumours after the adenomas

In contrast to adenomas these lesions are less homogeneous

and often have irregular margins The most common

primaries are bronchial carcinoma (25ndash30 ) breast

carcinoma and malignant melanoma Other possible sources

are gastrointestinal urological and gynecological tumours

(renal carcinoma gastric carcinoma pancreatic carcinoma

and others) Adrenal metastases are bilateral in up to 30 of

cases and this can produce the clinical manifestations of

Addison disease Bronchial carcinoma is virtually the only

tumour that is associated with isolated adrenal metastases

(in ca 15-20 )

Large metastasis from bronchial carcinoma on the right

side with a very inhomogeneous internal structure Solid

components are seen along with central liquid areas

Transverse scan shows a metastasis with a complex echo structure ldquowedgedrdquo between right lobe of the liver inferior vena cava the kidney and spinal column

Transverse scan of a metastasis of the right adrenal gland with complex structure beside a primary tumour of lung cancer

Partial metastases esp of lung cancer show

a wash out of contrast media in late phase

US examination longitudinal view Above the right kidney in the adrenal region a solid slightly inhomogeneous mass can be seen Neuroblastoma MRI examination

axial T2 weighted image Irregular large solid inhomogeneous retroperitoneal tumor

Pheochromocytoma Pheochromocytoma is a tumour of the adrenal medulla that is generally

detected sonographically (80ndash90 of cases) following the appearance

of clinical symptoms (hypertension and tachycardia caused by

increased catecholamine secretion)

Most pheochromocytomas are already several centimeters in diameter

when diagnosed They have smooth margins a round shape and a

nonhomogeneous or complex echo structure

Hypoechoic liquid components are also observed A spectrum of

appearances may be seen Pheochromocytomas are bilateral in

approximately 10 of cases and extra-adrenal in 10ndash20

The ldquoZuckerkandl organrdquo should be looked for at the level of the origin

of the inferior mesenteric artery anterior to the aorta

Other extra-adrenal sites are the renal hilum bladder wall and thorax

Pheochromocytoma is occasionally seen posterior to the renal vein in

transverse scans Rarely pheochromocytoma is diagnosed in the

setting of multiple endocrine neoplasia (MEN) From 2 to 5 of

pheochromocytomas are malignant Owing to the risk of inciting a

hypertensive crisis fine-needle aspiration biopsy causes discrepant

discussions about FNB

Nonhomogeneous tumour with a hyperechoic center (positive endocrine test increased catecholamine secretion) ndash Pheochromocytoma

Large functionally active pheochromocytoma (7 cm in diameter) The scan shows that most of tumour is hypoechoic with some hyperechoic regions

Lymphoma The adrenal region is a rare extranodal site of occurrence for lymphoma

Foci of lymphomatous infiltration have smooth borders and are

hypoechoic Differentiation is required from lymphomas in the renal or

splenic hilum If invasion by lymphoma is suspected other nodal

stations should be scanned and commonly infiltrated organs (spleen

liver) should be closely scrutinized

Perisplenic lymphoma in the left adrenal region of a patient with B-cell lymphoma

Colour Doppler shows hypervascularisation of the lymphatic tissue

Adrenal Carcinoma Adrenal carcinoma is usually inhomogeneous hypoechoic or echo complex with irregular margins It frequently infiltrates its surroundings and metastases can be demonstrated in the adrenal region and in other organs (eg the liver) The adrenal carcinoma is a very rare (1 17 million inhabitants) highly malignant tumour with a poor prognosis Adrenal carcinoma is indistinguishable sonographically from a metastasis although the visualization of additional tumours can advance the differential diagnosis Most adrenal carcinomas are hormone-producing Sometimes one can get evidence from detection of other tumour sign The tumour is usually detected only after it has reached considerable size (often gt8 cm) Intratumoral hemorrhage necrotic foci and calcifications may occur adding to the variegated appearance

Adrenal carcinoma may be hypoechoic or may have a complex echo structure Usually it

was relatively large when diagnosed (in this case 8 cm times 9 cm) and had irregular margins

Right adrenal adenocarcinoma A Sonogram showing a complex mass with cystic changes in the right adrenal gland (arrows) B Computed tomogram showing the mass (arrows)

Incidentaloma An incidentaloma is an adrenal tumour that is detected incidentally in an asymptomatic patient Incidentalomas are found in 1 of CT examinations They are much less common in ultrasound examinations because of the difficulty in defining small lesions (lt 2 cm) The predominantly hypoechoic tumours account for the great majority of incidentalomas shows the algorithm used in the investigation of incidentalomas Approximately 10 to 15 of these tumours are hormonally active In some cases ultrasound-guided fine-needle aspiration can also aid in the evaluation of incidentalomas but only ca 1 to 2 of these tumours are malignant

Abdominal ultrasound examination incidentally found most hypoechoic lesions

smaller 2 cm without clinical symptoms ndash which is typical for incidentalomas

Histoplasmosis is a geographically restricted form of

fungal infection Adrenal involvement is seen in disseminated disease but sometimes it may be the only site of demonstrable disease Early diagnosis and treatment may save the patient from catastrophic adrenal insufficiency We present two patients showing bilateral adrenomegaly on ultrasonography and contrast-enhanced CT and was diagnosed to have histoplasmosis on fine-needle aspiration cytology

Histoplasmosis is an infective condition caused by a

dimorphic saprophytic fungus Histoplasma capsulatum and is acquired by inhalation of its spores Soil rich in bird and bat dropping is its natural habitat and it exists as a mycelium in the atmosphere

Both adrenal gland were enlarged and hypoechoic at US study

US show bilateral hypoechoic lesions and CT showed peripherally enhancing hypodense bilateral adrenals with peripheral rim and septate enhancement

ULTRASOUND OF THE ADULT KIDNEY ndash Normal

Coronal scan plane for the Right Kidney Longitudinal Normal Kidney

Scan plane transverse kidney Transverse normal image

Common anatomical variantsAtrophic small kidneyHorseshoe kidneyEctopic kidneyDuplex kidneyCross fused ectopiaUnilateral renal agenesis

COMMON PATHOLOGYCalculusRenal cyst Cortical and Para-pelvicAngiomyolipmaRenal infectionRenal cell carcinomaTransitional cell carcinomaMedullary sponge kidneyPolycystic kidney disease

Horseshoe kidney A transverse and longitudinal view across the midline showing the isthmus across the aorta

Cross fused ectopic kidney The left kidney is fused to the lower pole of the right kidney

A baggy extra-renal pelvis

Pelvic ectopic kidney

UltrasonographyOn sonograms stones are demonstrated as bright echogenic foci with posterior acoustic shadowing Stones are visualized fairly well with US in the kidneys and the distal ureter at or near the UVJ especially if dilatation is present US is good for the visualization of complications such as hydronephrosis (or other signs of obstruction) however some patients with acute obstruction have little or no dilationIn particular US is helpful in evaluating those with renal insufficiency or contraindications for the use of contrast media however US is often skipped in favor of nonenhanced CTIn addition US is good for characterizing lucent filling defects that are visualized as stones on IVU However US does not provide direct physiologic information regarding the degree of obstruction Doppler imaging may demonstrate a high resistive index in acute obstruction but this may not occur immediately or after forniceal rupture Absence of the ureteral jet as visualized with color Doppler on the symptomatic side is presumptive evidence for a high-grade obstruction in a well-hydrated patient

Degree of confidenceUS is very insensitive for stones especially stones smaller than 2 mm stones at the UPJ or stones in the mid ureter Fowler et al suggest that US has a sensitivity as low as 24 compared with nonenhanced CT Furthermore estimations of stone size may not be accurate Compared with nonenhanced CT US is more dependent on the operators ability and more time consuming

False positivesnegativesUS is fairly specific when stones are seen with a specificity as high as 90 With US matrix or indinavir stones may have soft tissue echogenicity without shadowing False-positive findings may result from renal vascular calcifications False-positive diagnoses of hydronephrosis also result from dilated vascular structures in the renal hilum Doppler imaging is helpful in distinguishing dilated vascular structures from hydronephrosis

Renal sonogram demonstrates an echogenic shadowing calculus in the renal collecting system with hydronephrosis

US images for renal stones

US images of staghorn stones

US images for ureteric stones

US images for nephrocalcinosis

Renal cystA renal cyst is a fluid collection in the kidney There are several types based on the Bosniak classification The majority are benign simple cysts that can be monitored and not intervened upon However some are cancerous or are suspicious for cancer and are commonly removed in a surgical procedure called nephrectomyNumerous renal cysts are seen in the cystic kidney diseases which include polycystic kidney diseaseand medullary sponge kidney

The Bosniak classification categorizes renal cysts into five groupsCategory I

Benign simple cyst with thin wall without septa calcifications or solid

components

It does not enhance with contrast and has a density equal to that of water

Category IIBenign cyst with a few thin septa which may contain fine calcifications or a

small

segment of mildly thickened calcification This includes homogenous

high-attenuation lesions less than 3 cm with sharp margins(Rich Kosak) but

without enhancement

Category IIFWell marginated cysts with a number of thin septa with or without mild

enhancement or thickening of septa Calcifications may be present these

may be thick and nodular There are no enhancing soft tissue components

This also includes nonenhancing high-attenuation lesions that are completely

contained within the kidney and are 3 cm or larger

Category IIIIndeterminate cystic masses with thickened irregular septa with enhancement

Category IVMalignant cystic masses with all the characteristics of category III lesions

but also with enhancing soft tissue components independent of but adjacent

to the septa

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 11)

Classic findings of a simple cyst(Bosniak category 111)

Classic findings of a simple cyst(Bosniak category 1V)

Para-pelvic cyst USamp CT images

US of polycystic kidney disease

Renal infection

US of acute pyelonephritis

Acute bacterial pyelonephritis (a) US scan shows a wedge-shaped hyperechoic focus (arrowhead) in the upper pole of the right kidney related to acute bacterial pyelonephritis (b) Color flow US image demonstrates diminished flow through the involved area

US and color Doppler images of right kidney shows focal hyperechoic nephritis with decreased perfusion at the Doppler US

US and color Doppler images of kidney shows two multifocal nephritis with decreased perfusion at the Doppler US

Masslike appearance of acute bacterial pyelonephritis US and CT images

Emphysematous pyelonephritis (a) US image shows nondependent echoes within the left kidney that demonstrate a ring-down artifact (b) Corresponding CT scan helps confirm that this pattern is caused by intraparenchymal air

Xanthogranulomatous pyelonephritis (a) Contrast-enhanced CT scan demonstrates bilateral staghorn calculi with distention of the right collecting system secondary to inflammatory debris (b) US scan also shows the dilated

collecting system (arrowheads) and a shadowing calculus (arrow)

Early and mature abscess cavities (a) US scan demonstrates a geographic hypoechoic focus from an abscess in the upper pole of the right kidney (b) On a US scan of a more mature abscess the cavity is better defined with a visible pseudocapsule and through transmission that is evidenced by increased echogenicity deep to the upper pole lesion

Pyohydronephrosis

Pyohydronephrosis

Renal hydatidosis is an insidious disease and patients

often present with nonspecific clinical signs or symptoms Presenting complaints are dull flank pain hematuria palpable flank mass hypertension and renal colic

Disseminated abdominal retroperitoneal and pelvic hydatid disease (a) The right kidney is pushed to the midline and the left kidney is hydronephrotic and shrunken by retroperitoneal hydatid cysts (b) Ultrasound of the abdomen showing cystic lesions in the retroperitoneum in the position of the kidneys

Hydatid disease of the kidney US and CT images

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 21: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Calcification Complete or partial calcification of the adrenal glands is characterized by a

typical echo complex with a posterior acoustic shadow Calcifications can

result from a retained intra-adrenal hemorrhage or a prior inflammatory

process (eg tuberculosis) Patients occasionally show the clinical

manifestations of Addison disease However calcifications can also develop in

tumours (carcinoma metastases Pheochromocytoma adenoma)

In the proximal left kidney in the adrenal gland region wefound a classical calcification with dorsal acoustic shadow

Small calcifications also occur in tumours of adrenal gland most often observed in pheochromocytoma

Malignant adrenal gland tumours Metastases With their rich blood supply the adrenal glands are the fourth

most frequent site for hematogenous metastasis Metastases

to the adrenal glands account for the majority of solid adrenal

tumours after the adenomas

In contrast to adenomas these lesions are less homogeneous

and often have irregular margins The most common

primaries are bronchial carcinoma (25ndash30 ) breast

carcinoma and malignant melanoma Other possible sources

are gastrointestinal urological and gynecological tumours

(renal carcinoma gastric carcinoma pancreatic carcinoma

and others) Adrenal metastases are bilateral in up to 30 of

cases and this can produce the clinical manifestations of

Addison disease Bronchial carcinoma is virtually the only

tumour that is associated with isolated adrenal metastases

(in ca 15-20 )

Large metastasis from bronchial carcinoma on the right

side with a very inhomogeneous internal structure Solid

components are seen along with central liquid areas

Transverse scan shows a metastasis with a complex echo structure ldquowedgedrdquo between right lobe of the liver inferior vena cava the kidney and spinal column

Transverse scan of a metastasis of the right adrenal gland with complex structure beside a primary tumour of lung cancer

Partial metastases esp of lung cancer show

a wash out of contrast media in late phase

US examination longitudinal view Above the right kidney in the adrenal region a solid slightly inhomogeneous mass can be seen Neuroblastoma MRI examination

axial T2 weighted image Irregular large solid inhomogeneous retroperitoneal tumor

Pheochromocytoma Pheochromocytoma is a tumour of the adrenal medulla that is generally

detected sonographically (80ndash90 of cases) following the appearance

of clinical symptoms (hypertension and tachycardia caused by

increased catecholamine secretion)

Most pheochromocytomas are already several centimeters in diameter

when diagnosed They have smooth margins a round shape and a

nonhomogeneous or complex echo structure

Hypoechoic liquid components are also observed A spectrum of

appearances may be seen Pheochromocytomas are bilateral in

approximately 10 of cases and extra-adrenal in 10ndash20

The ldquoZuckerkandl organrdquo should be looked for at the level of the origin

of the inferior mesenteric artery anterior to the aorta

Other extra-adrenal sites are the renal hilum bladder wall and thorax

Pheochromocytoma is occasionally seen posterior to the renal vein in

transverse scans Rarely pheochromocytoma is diagnosed in the

setting of multiple endocrine neoplasia (MEN) From 2 to 5 of

pheochromocytomas are malignant Owing to the risk of inciting a

hypertensive crisis fine-needle aspiration biopsy causes discrepant

discussions about FNB

Nonhomogeneous tumour with a hyperechoic center (positive endocrine test increased catecholamine secretion) ndash Pheochromocytoma

Large functionally active pheochromocytoma (7 cm in diameter) The scan shows that most of tumour is hypoechoic with some hyperechoic regions

Lymphoma The adrenal region is a rare extranodal site of occurrence for lymphoma

Foci of lymphomatous infiltration have smooth borders and are

hypoechoic Differentiation is required from lymphomas in the renal or

splenic hilum If invasion by lymphoma is suspected other nodal

stations should be scanned and commonly infiltrated organs (spleen

liver) should be closely scrutinized

Perisplenic lymphoma in the left adrenal region of a patient with B-cell lymphoma

Colour Doppler shows hypervascularisation of the lymphatic tissue

Adrenal Carcinoma Adrenal carcinoma is usually inhomogeneous hypoechoic or echo complex with irregular margins It frequently infiltrates its surroundings and metastases can be demonstrated in the adrenal region and in other organs (eg the liver) The adrenal carcinoma is a very rare (1 17 million inhabitants) highly malignant tumour with a poor prognosis Adrenal carcinoma is indistinguishable sonographically from a metastasis although the visualization of additional tumours can advance the differential diagnosis Most adrenal carcinomas are hormone-producing Sometimes one can get evidence from detection of other tumour sign The tumour is usually detected only after it has reached considerable size (often gt8 cm) Intratumoral hemorrhage necrotic foci and calcifications may occur adding to the variegated appearance

Adrenal carcinoma may be hypoechoic or may have a complex echo structure Usually it

was relatively large when diagnosed (in this case 8 cm times 9 cm) and had irregular margins

Right adrenal adenocarcinoma A Sonogram showing a complex mass with cystic changes in the right adrenal gland (arrows) B Computed tomogram showing the mass (arrows)

Incidentaloma An incidentaloma is an adrenal tumour that is detected incidentally in an asymptomatic patient Incidentalomas are found in 1 of CT examinations They are much less common in ultrasound examinations because of the difficulty in defining small lesions (lt 2 cm) The predominantly hypoechoic tumours account for the great majority of incidentalomas shows the algorithm used in the investigation of incidentalomas Approximately 10 to 15 of these tumours are hormonally active In some cases ultrasound-guided fine-needle aspiration can also aid in the evaluation of incidentalomas but only ca 1 to 2 of these tumours are malignant

Abdominal ultrasound examination incidentally found most hypoechoic lesions

smaller 2 cm without clinical symptoms ndash which is typical for incidentalomas

Histoplasmosis is a geographically restricted form of

fungal infection Adrenal involvement is seen in disseminated disease but sometimes it may be the only site of demonstrable disease Early diagnosis and treatment may save the patient from catastrophic adrenal insufficiency We present two patients showing bilateral adrenomegaly on ultrasonography and contrast-enhanced CT and was diagnosed to have histoplasmosis on fine-needle aspiration cytology

Histoplasmosis is an infective condition caused by a

dimorphic saprophytic fungus Histoplasma capsulatum and is acquired by inhalation of its spores Soil rich in bird and bat dropping is its natural habitat and it exists as a mycelium in the atmosphere

Both adrenal gland were enlarged and hypoechoic at US study

US show bilateral hypoechoic lesions and CT showed peripherally enhancing hypodense bilateral adrenals with peripheral rim and septate enhancement

ULTRASOUND OF THE ADULT KIDNEY ndash Normal

Coronal scan plane for the Right Kidney Longitudinal Normal Kidney

Scan plane transverse kidney Transverse normal image

Common anatomical variantsAtrophic small kidneyHorseshoe kidneyEctopic kidneyDuplex kidneyCross fused ectopiaUnilateral renal agenesis

COMMON PATHOLOGYCalculusRenal cyst Cortical and Para-pelvicAngiomyolipmaRenal infectionRenal cell carcinomaTransitional cell carcinomaMedullary sponge kidneyPolycystic kidney disease

Horseshoe kidney A transverse and longitudinal view across the midline showing the isthmus across the aorta

Cross fused ectopic kidney The left kidney is fused to the lower pole of the right kidney

A baggy extra-renal pelvis

Pelvic ectopic kidney

UltrasonographyOn sonograms stones are demonstrated as bright echogenic foci with posterior acoustic shadowing Stones are visualized fairly well with US in the kidneys and the distal ureter at or near the UVJ especially if dilatation is present US is good for the visualization of complications such as hydronephrosis (or other signs of obstruction) however some patients with acute obstruction have little or no dilationIn particular US is helpful in evaluating those with renal insufficiency or contraindications for the use of contrast media however US is often skipped in favor of nonenhanced CTIn addition US is good for characterizing lucent filling defects that are visualized as stones on IVU However US does not provide direct physiologic information regarding the degree of obstruction Doppler imaging may demonstrate a high resistive index in acute obstruction but this may not occur immediately or after forniceal rupture Absence of the ureteral jet as visualized with color Doppler on the symptomatic side is presumptive evidence for a high-grade obstruction in a well-hydrated patient

Degree of confidenceUS is very insensitive for stones especially stones smaller than 2 mm stones at the UPJ or stones in the mid ureter Fowler et al suggest that US has a sensitivity as low as 24 compared with nonenhanced CT Furthermore estimations of stone size may not be accurate Compared with nonenhanced CT US is more dependent on the operators ability and more time consuming

False positivesnegativesUS is fairly specific when stones are seen with a specificity as high as 90 With US matrix or indinavir stones may have soft tissue echogenicity without shadowing False-positive findings may result from renal vascular calcifications False-positive diagnoses of hydronephrosis also result from dilated vascular structures in the renal hilum Doppler imaging is helpful in distinguishing dilated vascular structures from hydronephrosis

Renal sonogram demonstrates an echogenic shadowing calculus in the renal collecting system with hydronephrosis

US images for renal stones

US images of staghorn stones

US images for ureteric stones

US images for nephrocalcinosis

Renal cystA renal cyst is a fluid collection in the kidney There are several types based on the Bosniak classification The majority are benign simple cysts that can be monitored and not intervened upon However some are cancerous or are suspicious for cancer and are commonly removed in a surgical procedure called nephrectomyNumerous renal cysts are seen in the cystic kidney diseases which include polycystic kidney diseaseand medullary sponge kidney

The Bosniak classification categorizes renal cysts into five groupsCategory I

Benign simple cyst with thin wall without septa calcifications or solid

components

It does not enhance with contrast and has a density equal to that of water

Category IIBenign cyst with a few thin septa which may contain fine calcifications or a

small

segment of mildly thickened calcification This includes homogenous

high-attenuation lesions less than 3 cm with sharp margins(Rich Kosak) but

without enhancement

Category IIFWell marginated cysts with a number of thin septa with or without mild

enhancement or thickening of septa Calcifications may be present these

may be thick and nodular There are no enhancing soft tissue components

This also includes nonenhancing high-attenuation lesions that are completely

contained within the kidney and are 3 cm or larger

Category IIIIndeterminate cystic masses with thickened irregular septa with enhancement

Category IVMalignant cystic masses with all the characteristics of category III lesions

but also with enhancing soft tissue components independent of but adjacent

to the septa

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 11)

Classic findings of a simple cyst(Bosniak category 111)

Classic findings of a simple cyst(Bosniak category 1V)

Para-pelvic cyst USamp CT images

US of polycystic kidney disease

Renal infection

US of acute pyelonephritis

Acute bacterial pyelonephritis (a) US scan shows a wedge-shaped hyperechoic focus (arrowhead) in the upper pole of the right kidney related to acute bacterial pyelonephritis (b) Color flow US image demonstrates diminished flow through the involved area

US and color Doppler images of right kidney shows focal hyperechoic nephritis with decreased perfusion at the Doppler US

US and color Doppler images of kidney shows two multifocal nephritis with decreased perfusion at the Doppler US

Masslike appearance of acute bacterial pyelonephritis US and CT images

Emphysematous pyelonephritis (a) US image shows nondependent echoes within the left kidney that demonstrate a ring-down artifact (b) Corresponding CT scan helps confirm that this pattern is caused by intraparenchymal air

Xanthogranulomatous pyelonephritis (a) Contrast-enhanced CT scan demonstrates bilateral staghorn calculi with distention of the right collecting system secondary to inflammatory debris (b) US scan also shows the dilated

collecting system (arrowheads) and a shadowing calculus (arrow)

Early and mature abscess cavities (a) US scan demonstrates a geographic hypoechoic focus from an abscess in the upper pole of the right kidney (b) On a US scan of a more mature abscess the cavity is better defined with a visible pseudocapsule and through transmission that is evidenced by increased echogenicity deep to the upper pole lesion

Pyohydronephrosis

Pyohydronephrosis

Renal hydatidosis is an insidious disease and patients

often present with nonspecific clinical signs or symptoms Presenting complaints are dull flank pain hematuria palpable flank mass hypertension and renal colic

Disseminated abdominal retroperitoneal and pelvic hydatid disease (a) The right kidney is pushed to the midline and the left kidney is hydronephrotic and shrunken by retroperitoneal hydatid cysts (b) Ultrasound of the abdomen showing cystic lesions in the retroperitoneum in the position of the kidneys

Hydatid disease of the kidney US and CT images

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 22: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Small calcifications also occur in tumours of adrenal gland most often observed in pheochromocytoma

Malignant adrenal gland tumours Metastases With their rich blood supply the adrenal glands are the fourth

most frequent site for hematogenous metastasis Metastases

to the adrenal glands account for the majority of solid adrenal

tumours after the adenomas

In contrast to adenomas these lesions are less homogeneous

and often have irregular margins The most common

primaries are bronchial carcinoma (25ndash30 ) breast

carcinoma and malignant melanoma Other possible sources

are gastrointestinal urological and gynecological tumours

(renal carcinoma gastric carcinoma pancreatic carcinoma

and others) Adrenal metastases are bilateral in up to 30 of

cases and this can produce the clinical manifestations of

Addison disease Bronchial carcinoma is virtually the only

tumour that is associated with isolated adrenal metastases

(in ca 15-20 )

Large metastasis from bronchial carcinoma on the right

side with a very inhomogeneous internal structure Solid

components are seen along with central liquid areas

Transverse scan shows a metastasis with a complex echo structure ldquowedgedrdquo between right lobe of the liver inferior vena cava the kidney and spinal column

Transverse scan of a metastasis of the right adrenal gland with complex structure beside a primary tumour of lung cancer

Partial metastases esp of lung cancer show

a wash out of contrast media in late phase

US examination longitudinal view Above the right kidney in the adrenal region a solid slightly inhomogeneous mass can be seen Neuroblastoma MRI examination

axial T2 weighted image Irregular large solid inhomogeneous retroperitoneal tumor

Pheochromocytoma Pheochromocytoma is a tumour of the adrenal medulla that is generally

detected sonographically (80ndash90 of cases) following the appearance

of clinical symptoms (hypertension and tachycardia caused by

increased catecholamine secretion)

Most pheochromocytomas are already several centimeters in diameter

when diagnosed They have smooth margins a round shape and a

nonhomogeneous or complex echo structure

Hypoechoic liquid components are also observed A spectrum of

appearances may be seen Pheochromocytomas are bilateral in

approximately 10 of cases and extra-adrenal in 10ndash20

The ldquoZuckerkandl organrdquo should be looked for at the level of the origin

of the inferior mesenteric artery anterior to the aorta

Other extra-adrenal sites are the renal hilum bladder wall and thorax

Pheochromocytoma is occasionally seen posterior to the renal vein in

transverse scans Rarely pheochromocytoma is diagnosed in the

setting of multiple endocrine neoplasia (MEN) From 2 to 5 of

pheochromocytomas are malignant Owing to the risk of inciting a

hypertensive crisis fine-needle aspiration biopsy causes discrepant

discussions about FNB

Nonhomogeneous tumour with a hyperechoic center (positive endocrine test increased catecholamine secretion) ndash Pheochromocytoma

Large functionally active pheochromocytoma (7 cm in diameter) The scan shows that most of tumour is hypoechoic with some hyperechoic regions

Lymphoma The adrenal region is a rare extranodal site of occurrence for lymphoma

Foci of lymphomatous infiltration have smooth borders and are

hypoechoic Differentiation is required from lymphomas in the renal or

splenic hilum If invasion by lymphoma is suspected other nodal

stations should be scanned and commonly infiltrated organs (spleen

liver) should be closely scrutinized

Perisplenic lymphoma in the left adrenal region of a patient with B-cell lymphoma

Colour Doppler shows hypervascularisation of the lymphatic tissue

Adrenal Carcinoma Adrenal carcinoma is usually inhomogeneous hypoechoic or echo complex with irregular margins It frequently infiltrates its surroundings and metastases can be demonstrated in the adrenal region and in other organs (eg the liver) The adrenal carcinoma is a very rare (1 17 million inhabitants) highly malignant tumour with a poor prognosis Adrenal carcinoma is indistinguishable sonographically from a metastasis although the visualization of additional tumours can advance the differential diagnosis Most adrenal carcinomas are hormone-producing Sometimes one can get evidence from detection of other tumour sign The tumour is usually detected only after it has reached considerable size (often gt8 cm) Intratumoral hemorrhage necrotic foci and calcifications may occur adding to the variegated appearance

Adrenal carcinoma may be hypoechoic or may have a complex echo structure Usually it

was relatively large when diagnosed (in this case 8 cm times 9 cm) and had irregular margins

Right adrenal adenocarcinoma A Sonogram showing a complex mass with cystic changes in the right adrenal gland (arrows) B Computed tomogram showing the mass (arrows)

Incidentaloma An incidentaloma is an adrenal tumour that is detected incidentally in an asymptomatic patient Incidentalomas are found in 1 of CT examinations They are much less common in ultrasound examinations because of the difficulty in defining small lesions (lt 2 cm) The predominantly hypoechoic tumours account for the great majority of incidentalomas shows the algorithm used in the investigation of incidentalomas Approximately 10 to 15 of these tumours are hormonally active In some cases ultrasound-guided fine-needle aspiration can also aid in the evaluation of incidentalomas but only ca 1 to 2 of these tumours are malignant

Abdominal ultrasound examination incidentally found most hypoechoic lesions

smaller 2 cm without clinical symptoms ndash which is typical for incidentalomas

Histoplasmosis is a geographically restricted form of

fungal infection Adrenal involvement is seen in disseminated disease but sometimes it may be the only site of demonstrable disease Early diagnosis and treatment may save the patient from catastrophic adrenal insufficiency We present two patients showing bilateral adrenomegaly on ultrasonography and contrast-enhanced CT and was diagnosed to have histoplasmosis on fine-needle aspiration cytology

Histoplasmosis is an infective condition caused by a

dimorphic saprophytic fungus Histoplasma capsulatum and is acquired by inhalation of its spores Soil rich in bird and bat dropping is its natural habitat and it exists as a mycelium in the atmosphere

Both adrenal gland were enlarged and hypoechoic at US study

US show bilateral hypoechoic lesions and CT showed peripherally enhancing hypodense bilateral adrenals with peripheral rim and septate enhancement

ULTRASOUND OF THE ADULT KIDNEY ndash Normal

Coronal scan plane for the Right Kidney Longitudinal Normal Kidney

Scan plane transverse kidney Transverse normal image

Common anatomical variantsAtrophic small kidneyHorseshoe kidneyEctopic kidneyDuplex kidneyCross fused ectopiaUnilateral renal agenesis

COMMON PATHOLOGYCalculusRenal cyst Cortical and Para-pelvicAngiomyolipmaRenal infectionRenal cell carcinomaTransitional cell carcinomaMedullary sponge kidneyPolycystic kidney disease

Horseshoe kidney A transverse and longitudinal view across the midline showing the isthmus across the aorta

Cross fused ectopic kidney The left kidney is fused to the lower pole of the right kidney

A baggy extra-renal pelvis

Pelvic ectopic kidney

UltrasonographyOn sonograms stones are demonstrated as bright echogenic foci with posterior acoustic shadowing Stones are visualized fairly well with US in the kidneys and the distal ureter at or near the UVJ especially if dilatation is present US is good for the visualization of complications such as hydronephrosis (or other signs of obstruction) however some patients with acute obstruction have little or no dilationIn particular US is helpful in evaluating those with renal insufficiency or contraindications for the use of contrast media however US is often skipped in favor of nonenhanced CTIn addition US is good for characterizing lucent filling defects that are visualized as stones on IVU However US does not provide direct physiologic information regarding the degree of obstruction Doppler imaging may demonstrate a high resistive index in acute obstruction but this may not occur immediately or after forniceal rupture Absence of the ureteral jet as visualized with color Doppler on the symptomatic side is presumptive evidence for a high-grade obstruction in a well-hydrated patient

Degree of confidenceUS is very insensitive for stones especially stones smaller than 2 mm stones at the UPJ or stones in the mid ureter Fowler et al suggest that US has a sensitivity as low as 24 compared with nonenhanced CT Furthermore estimations of stone size may not be accurate Compared with nonenhanced CT US is more dependent on the operators ability and more time consuming

False positivesnegativesUS is fairly specific when stones are seen with a specificity as high as 90 With US matrix or indinavir stones may have soft tissue echogenicity without shadowing False-positive findings may result from renal vascular calcifications False-positive diagnoses of hydronephrosis also result from dilated vascular structures in the renal hilum Doppler imaging is helpful in distinguishing dilated vascular structures from hydronephrosis

Renal sonogram demonstrates an echogenic shadowing calculus in the renal collecting system with hydronephrosis

US images for renal stones

US images of staghorn stones

US images for ureteric stones

US images for nephrocalcinosis

Renal cystA renal cyst is a fluid collection in the kidney There are several types based on the Bosniak classification The majority are benign simple cysts that can be monitored and not intervened upon However some are cancerous or are suspicious for cancer and are commonly removed in a surgical procedure called nephrectomyNumerous renal cysts are seen in the cystic kidney diseases which include polycystic kidney diseaseand medullary sponge kidney

The Bosniak classification categorizes renal cysts into five groupsCategory I

Benign simple cyst with thin wall without septa calcifications or solid

components

It does not enhance with contrast and has a density equal to that of water

Category IIBenign cyst with a few thin septa which may contain fine calcifications or a

small

segment of mildly thickened calcification This includes homogenous

high-attenuation lesions less than 3 cm with sharp margins(Rich Kosak) but

without enhancement

Category IIFWell marginated cysts with a number of thin septa with or without mild

enhancement or thickening of septa Calcifications may be present these

may be thick and nodular There are no enhancing soft tissue components

This also includes nonenhancing high-attenuation lesions that are completely

contained within the kidney and are 3 cm or larger

Category IIIIndeterminate cystic masses with thickened irregular septa with enhancement

Category IVMalignant cystic masses with all the characteristics of category III lesions

but also with enhancing soft tissue components independent of but adjacent

to the septa

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 11)

Classic findings of a simple cyst(Bosniak category 111)

Classic findings of a simple cyst(Bosniak category 1V)

Para-pelvic cyst USamp CT images

US of polycystic kidney disease

Renal infection

US of acute pyelonephritis

Acute bacterial pyelonephritis (a) US scan shows a wedge-shaped hyperechoic focus (arrowhead) in the upper pole of the right kidney related to acute bacterial pyelonephritis (b) Color flow US image demonstrates diminished flow through the involved area

US and color Doppler images of right kidney shows focal hyperechoic nephritis with decreased perfusion at the Doppler US

US and color Doppler images of kidney shows two multifocal nephritis with decreased perfusion at the Doppler US

Masslike appearance of acute bacterial pyelonephritis US and CT images

Emphysematous pyelonephritis (a) US image shows nondependent echoes within the left kidney that demonstrate a ring-down artifact (b) Corresponding CT scan helps confirm that this pattern is caused by intraparenchymal air

Xanthogranulomatous pyelonephritis (a) Contrast-enhanced CT scan demonstrates bilateral staghorn calculi with distention of the right collecting system secondary to inflammatory debris (b) US scan also shows the dilated

collecting system (arrowheads) and a shadowing calculus (arrow)

Early and mature abscess cavities (a) US scan demonstrates a geographic hypoechoic focus from an abscess in the upper pole of the right kidney (b) On a US scan of a more mature abscess the cavity is better defined with a visible pseudocapsule and through transmission that is evidenced by increased echogenicity deep to the upper pole lesion

Pyohydronephrosis

Pyohydronephrosis

Renal hydatidosis is an insidious disease and patients

often present with nonspecific clinical signs or symptoms Presenting complaints are dull flank pain hematuria palpable flank mass hypertension and renal colic

Disseminated abdominal retroperitoneal and pelvic hydatid disease (a) The right kidney is pushed to the midline and the left kidney is hydronephrotic and shrunken by retroperitoneal hydatid cysts (b) Ultrasound of the abdomen showing cystic lesions in the retroperitoneum in the position of the kidneys

Hydatid disease of the kidney US and CT images

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 23: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Malignant adrenal gland tumours Metastases With their rich blood supply the adrenal glands are the fourth

most frequent site for hematogenous metastasis Metastases

to the adrenal glands account for the majority of solid adrenal

tumours after the adenomas

In contrast to adenomas these lesions are less homogeneous

and often have irregular margins The most common

primaries are bronchial carcinoma (25ndash30 ) breast

carcinoma and malignant melanoma Other possible sources

are gastrointestinal urological and gynecological tumours

(renal carcinoma gastric carcinoma pancreatic carcinoma

and others) Adrenal metastases are bilateral in up to 30 of

cases and this can produce the clinical manifestations of

Addison disease Bronchial carcinoma is virtually the only

tumour that is associated with isolated adrenal metastases

(in ca 15-20 )

Large metastasis from bronchial carcinoma on the right

side with a very inhomogeneous internal structure Solid

components are seen along with central liquid areas

Transverse scan shows a metastasis with a complex echo structure ldquowedgedrdquo between right lobe of the liver inferior vena cava the kidney and spinal column

Transverse scan of a metastasis of the right adrenal gland with complex structure beside a primary tumour of lung cancer

Partial metastases esp of lung cancer show

a wash out of contrast media in late phase

US examination longitudinal view Above the right kidney in the adrenal region a solid slightly inhomogeneous mass can be seen Neuroblastoma MRI examination

axial T2 weighted image Irregular large solid inhomogeneous retroperitoneal tumor

Pheochromocytoma Pheochromocytoma is a tumour of the adrenal medulla that is generally

detected sonographically (80ndash90 of cases) following the appearance

of clinical symptoms (hypertension and tachycardia caused by

increased catecholamine secretion)

Most pheochromocytomas are already several centimeters in diameter

when diagnosed They have smooth margins a round shape and a

nonhomogeneous or complex echo structure

Hypoechoic liquid components are also observed A spectrum of

appearances may be seen Pheochromocytomas are bilateral in

approximately 10 of cases and extra-adrenal in 10ndash20

The ldquoZuckerkandl organrdquo should be looked for at the level of the origin

of the inferior mesenteric artery anterior to the aorta

Other extra-adrenal sites are the renal hilum bladder wall and thorax

Pheochromocytoma is occasionally seen posterior to the renal vein in

transverse scans Rarely pheochromocytoma is diagnosed in the

setting of multiple endocrine neoplasia (MEN) From 2 to 5 of

pheochromocytomas are malignant Owing to the risk of inciting a

hypertensive crisis fine-needle aspiration biopsy causes discrepant

discussions about FNB

Nonhomogeneous tumour with a hyperechoic center (positive endocrine test increased catecholamine secretion) ndash Pheochromocytoma

Large functionally active pheochromocytoma (7 cm in diameter) The scan shows that most of tumour is hypoechoic with some hyperechoic regions

Lymphoma The adrenal region is a rare extranodal site of occurrence for lymphoma

Foci of lymphomatous infiltration have smooth borders and are

hypoechoic Differentiation is required from lymphomas in the renal or

splenic hilum If invasion by lymphoma is suspected other nodal

stations should be scanned and commonly infiltrated organs (spleen

liver) should be closely scrutinized

Perisplenic lymphoma in the left adrenal region of a patient with B-cell lymphoma

Colour Doppler shows hypervascularisation of the lymphatic tissue

Adrenal Carcinoma Adrenal carcinoma is usually inhomogeneous hypoechoic or echo complex with irregular margins It frequently infiltrates its surroundings and metastases can be demonstrated in the adrenal region and in other organs (eg the liver) The adrenal carcinoma is a very rare (1 17 million inhabitants) highly malignant tumour with a poor prognosis Adrenal carcinoma is indistinguishable sonographically from a metastasis although the visualization of additional tumours can advance the differential diagnosis Most adrenal carcinomas are hormone-producing Sometimes one can get evidence from detection of other tumour sign The tumour is usually detected only after it has reached considerable size (often gt8 cm) Intratumoral hemorrhage necrotic foci and calcifications may occur adding to the variegated appearance

Adrenal carcinoma may be hypoechoic or may have a complex echo structure Usually it

was relatively large when diagnosed (in this case 8 cm times 9 cm) and had irregular margins

Right adrenal adenocarcinoma A Sonogram showing a complex mass with cystic changes in the right adrenal gland (arrows) B Computed tomogram showing the mass (arrows)

Incidentaloma An incidentaloma is an adrenal tumour that is detected incidentally in an asymptomatic patient Incidentalomas are found in 1 of CT examinations They are much less common in ultrasound examinations because of the difficulty in defining small lesions (lt 2 cm) The predominantly hypoechoic tumours account for the great majority of incidentalomas shows the algorithm used in the investigation of incidentalomas Approximately 10 to 15 of these tumours are hormonally active In some cases ultrasound-guided fine-needle aspiration can also aid in the evaluation of incidentalomas but only ca 1 to 2 of these tumours are malignant

Abdominal ultrasound examination incidentally found most hypoechoic lesions

smaller 2 cm without clinical symptoms ndash which is typical for incidentalomas

Histoplasmosis is a geographically restricted form of

fungal infection Adrenal involvement is seen in disseminated disease but sometimes it may be the only site of demonstrable disease Early diagnosis and treatment may save the patient from catastrophic adrenal insufficiency We present two patients showing bilateral adrenomegaly on ultrasonography and contrast-enhanced CT and was diagnosed to have histoplasmosis on fine-needle aspiration cytology

Histoplasmosis is an infective condition caused by a

dimorphic saprophytic fungus Histoplasma capsulatum and is acquired by inhalation of its spores Soil rich in bird and bat dropping is its natural habitat and it exists as a mycelium in the atmosphere

Both adrenal gland were enlarged and hypoechoic at US study

US show bilateral hypoechoic lesions and CT showed peripherally enhancing hypodense bilateral adrenals with peripheral rim and septate enhancement

ULTRASOUND OF THE ADULT KIDNEY ndash Normal

Coronal scan plane for the Right Kidney Longitudinal Normal Kidney

Scan plane transverse kidney Transverse normal image

Common anatomical variantsAtrophic small kidneyHorseshoe kidneyEctopic kidneyDuplex kidneyCross fused ectopiaUnilateral renal agenesis

COMMON PATHOLOGYCalculusRenal cyst Cortical and Para-pelvicAngiomyolipmaRenal infectionRenal cell carcinomaTransitional cell carcinomaMedullary sponge kidneyPolycystic kidney disease

Horseshoe kidney A transverse and longitudinal view across the midline showing the isthmus across the aorta

Cross fused ectopic kidney The left kidney is fused to the lower pole of the right kidney

A baggy extra-renal pelvis

Pelvic ectopic kidney

UltrasonographyOn sonograms stones are demonstrated as bright echogenic foci with posterior acoustic shadowing Stones are visualized fairly well with US in the kidneys and the distal ureter at or near the UVJ especially if dilatation is present US is good for the visualization of complications such as hydronephrosis (or other signs of obstruction) however some patients with acute obstruction have little or no dilationIn particular US is helpful in evaluating those with renal insufficiency or contraindications for the use of contrast media however US is often skipped in favor of nonenhanced CTIn addition US is good for characterizing lucent filling defects that are visualized as stones on IVU However US does not provide direct physiologic information regarding the degree of obstruction Doppler imaging may demonstrate a high resistive index in acute obstruction but this may not occur immediately or after forniceal rupture Absence of the ureteral jet as visualized with color Doppler on the symptomatic side is presumptive evidence for a high-grade obstruction in a well-hydrated patient

Degree of confidenceUS is very insensitive for stones especially stones smaller than 2 mm stones at the UPJ or stones in the mid ureter Fowler et al suggest that US has a sensitivity as low as 24 compared with nonenhanced CT Furthermore estimations of stone size may not be accurate Compared with nonenhanced CT US is more dependent on the operators ability and more time consuming

False positivesnegativesUS is fairly specific when stones are seen with a specificity as high as 90 With US matrix or indinavir stones may have soft tissue echogenicity without shadowing False-positive findings may result from renal vascular calcifications False-positive diagnoses of hydronephrosis also result from dilated vascular structures in the renal hilum Doppler imaging is helpful in distinguishing dilated vascular structures from hydronephrosis

Renal sonogram demonstrates an echogenic shadowing calculus in the renal collecting system with hydronephrosis

US images for renal stones

US images of staghorn stones

US images for ureteric stones

US images for nephrocalcinosis

Renal cystA renal cyst is a fluid collection in the kidney There are several types based on the Bosniak classification The majority are benign simple cysts that can be monitored and not intervened upon However some are cancerous or are suspicious for cancer and are commonly removed in a surgical procedure called nephrectomyNumerous renal cysts are seen in the cystic kidney diseases which include polycystic kidney diseaseand medullary sponge kidney

The Bosniak classification categorizes renal cysts into five groupsCategory I

Benign simple cyst with thin wall without septa calcifications or solid

components

It does not enhance with contrast and has a density equal to that of water

Category IIBenign cyst with a few thin septa which may contain fine calcifications or a

small

segment of mildly thickened calcification This includes homogenous

high-attenuation lesions less than 3 cm with sharp margins(Rich Kosak) but

without enhancement

Category IIFWell marginated cysts with a number of thin septa with or without mild

enhancement or thickening of septa Calcifications may be present these

may be thick and nodular There are no enhancing soft tissue components

This also includes nonenhancing high-attenuation lesions that are completely

contained within the kidney and are 3 cm or larger

Category IIIIndeterminate cystic masses with thickened irregular septa with enhancement

Category IVMalignant cystic masses with all the characteristics of category III lesions

but also with enhancing soft tissue components independent of but adjacent

to the septa

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 11)

Classic findings of a simple cyst(Bosniak category 111)

Classic findings of a simple cyst(Bosniak category 1V)

Para-pelvic cyst USamp CT images

US of polycystic kidney disease

Renal infection

US of acute pyelonephritis

Acute bacterial pyelonephritis (a) US scan shows a wedge-shaped hyperechoic focus (arrowhead) in the upper pole of the right kidney related to acute bacterial pyelonephritis (b) Color flow US image demonstrates diminished flow through the involved area

US and color Doppler images of right kidney shows focal hyperechoic nephritis with decreased perfusion at the Doppler US

US and color Doppler images of kidney shows two multifocal nephritis with decreased perfusion at the Doppler US

Masslike appearance of acute bacterial pyelonephritis US and CT images

Emphysematous pyelonephritis (a) US image shows nondependent echoes within the left kidney that demonstrate a ring-down artifact (b) Corresponding CT scan helps confirm that this pattern is caused by intraparenchymal air

Xanthogranulomatous pyelonephritis (a) Contrast-enhanced CT scan demonstrates bilateral staghorn calculi with distention of the right collecting system secondary to inflammatory debris (b) US scan also shows the dilated

collecting system (arrowheads) and a shadowing calculus (arrow)

Early and mature abscess cavities (a) US scan demonstrates a geographic hypoechoic focus from an abscess in the upper pole of the right kidney (b) On a US scan of a more mature abscess the cavity is better defined with a visible pseudocapsule and through transmission that is evidenced by increased echogenicity deep to the upper pole lesion

Pyohydronephrosis

Pyohydronephrosis

Renal hydatidosis is an insidious disease and patients

often present with nonspecific clinical signs or symptoms Presenting complaints are dull flank pain hematuria palpable flank mass hypertension and renal colic

Disseminated abdominal retroperitoneal and pelvic hydatid disease (a) The right kidney is pushed to the midline and the left kidney is hydronephrotic and shrunken by retroperitoneal hydatid cysts (b) Ultrasound of the abdomen showing cystic lesions in the retroperitoneum in the position of the kidneys

Hydatid disease of the kidney US and CT images

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 24: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Large metastasis from bronchial carcinoma on the right

side with a very inhomogeneous internal structure Solid

components are seen along with central liquid areas

Transverse scan shows a metastasis with a complex echo structure ldquowedgedrdquo between right lobe of the liver inferior vena cava the kidney and spinal column

Transverse scan of a metastasis of the right adrenal gland with complex structure beside a primary tumour of lung cancer

Partial metastases esp of lung cancer show

a wash out of contrast media in late phase

US examination longitudinal view Above the right kidney in the adrenal region a solid slightly inhomogeneous mass can be seen Neuroblastoma MRI examination

axial T2 weighted image Irregular large solid inhomogeneous retroperitoneal tumor

Pheochromocytoma Pheochromocytoma is a tumour of the adrenal medulla that is generally

detected sonographically (80ndash90 of cases) following the appearance

of clinical symptoms (hypertension and tachycardia caused by

increased catecholamine secretion)

Most pheochromocytomas are already several centimeters in diameter

when diagnosed They have smooth margins a round shape and a

nonhomogeneous or complex echo structure

Hypoechoic liquid components are also observed A spectrum of

appearances may be seen Pheochromocytomas are bilateral in

approximately 10 of cases and extra-adrenal in 10ndash20

The ldquoZuckerkandl organrdquo should be looked for at the level of the origin

of the inferior mesenteric artery anterior to the aorta

Other extra-adrenal sites are the renal hilum bladder wall and thorax

Pheochromocytoma is occasionally seen posterior to the renal vein in

transverse scans Rarely pheochromocytoma is diagnosed in the

setting of multiple endocrine neoplasia (MEN) From 2 to 5 of

pheochromocytomas are malignant Owing to the risk of inciting a

hypertensive crisis fine-needle aspiration biopsy causes discrepant

discussions about FNB

Nonhomogeneous tumour with a hyperechoic center (positive endocrine test increased catecholamine secretion) ndash Pheochromocytoma

Large functionally active pheochromocytoma (7 cm in diameter) The scan shows that most of tumour is hypoechoic with some hyperechoic regions

Lymphoma The adrenal region is a rare extranodal site of occurrence for lymphoma

Foci of lymphomatous infiltration have smooth borders and are

hypoechoic Differentiation is required from lymphomas in the renal or

splenic hilum If invasion by lymphoma is suspected other nodal

stations should be scanned and commonly infiltrated organs (spleen

liver) should be closely scrutinized

Perisplenic lymphoma in the left adrenal region of a patient with B-cell lymphoma

Colour Doppler shows hypervascularisation of the lymphatic tissue

Adrenal Carcinoma Adrenal carcinoma is usually inhomogeneous hypoechoic or echo complex with irregular margins It frequently infiltrates its surroundings and metastases can be demonstrated in the adrenal region and in other organs (eg the liver) The adrenal carcinoma is a very rare (1 17 million inhabitants) highly malignant tumour with a poor prognosis Adrenal carcinoma is indistinguishable sonographically from a metastasis although the visualization of additional tumours can advance the differential diagnosis Most adrenal carcinomas are hormone-producing Sometimes one can get evidence from detection of other tumour sign The tumour is usually detected only after it has reached considerable size (often gt8 cm) Intratumoral hemorrhage necrotic foci and calcifications may occur adding to the variegated appearance

Adrenal carcinoma may be hypoechoic or may have a complex echo structure Usually it

was relatively large when diagnosed (in this case 8 cm times 9 cm) and had irregular margins

Right adrenal adenocarcinoma A Sonogram showing a complex mass with cystic changes in the right adrenal gland (arrows) B Computed tomogram showing the mass (arrows)

Incidentaloma An incidentaloma is an adrenal tumour that is detected incidentally in an asymptomatic patient Incidentalomas are found in 1 of CT examinations They are much less common in ultrasound examinations because of the difficulty in defining small lesions (lt 2 cm) The predominantly hypoechoic tumours account for the great majority of incidentalomas shows the algorithm used in the investigation of incidentalomas Approximately 10 to 15 of these tumours are hormonally active In some cases ultrasound-guided fine-needle aspiration can also aid in the evaluation of incidentalomas but only ca 1 to 2 of these tumours are malignant

Abdominal ultrasound examination incidentally found most hypoechoic lesions

smaller 2 cm without clinical symptoms ndash which is typical for incidentalomas

Histoplasmosis is a geographically restricted form of

fungal infection Adrenal involvement is seen in disseminated disease but sometimes it may be the only site of demonstrable disease Early diagnosis and treatment may save the patient from catastrophic adrenal insufficiency We present two patients showing bilateral adrenomegaly on ultrasonography and contrast-enhanced CT and was diagnosed to have histoplasmosis on fine-needle aspiration cytology

Histoplasmosis is an infective condition caused by a

dimorphic saprophytic fungus Histoplasma capsulatum and is acquired by inhalation of its spores Soil rich in bird and bat dropping is its natural habitat and it exists as a mycelium in the atmosphere

Both adrenal gland were enlarged and hypoechoic at US study

US show bilateral hypoechoic lesions and CT showed peripherally enhancing hypodense bilateral adrenals with peripheral rim and septate enhancement

ULTRASOUND OF THE ADULT KIDNEY ndash Normal

Coronal scan plane for the Right Kidney Longitudinal Normal Kidney

Scan plane transverse kidney Transverse normal image

Common anatomical variantsAtrophic small kidneyHorseshoe kidneyEctopic kidneyDuplex kidneyCross fused ectopiaUnilateral renal agenesis

COMMON PATHOLOGYCalculusRenal cyst Cortical and Para-pelvicAngiomyolipmaRenal infectionRenal cell carcinomaTransitional cell carcinomaMedullary sponge kidneyPolycystic kidney disease

Horseshoe kidney A transverse and longitudinal view across the midline showing the isthmus across the aorta

Cross fused ectopic kidney The left kidney is fused to the lower pole of the right kidney

A baggy extra-renal pelvis

Pelvic ectopic kidney

UltrasonographyOn sonograms stones are demonstrated as bright echogenic foci with posterior acoustic shadowing Stones are visualized fairly well with US in the kidneys and the distal ureter at or near the UVJ especially if dilatation is present US is good for the visualization of complications such as hydronephrosis (or other signs of obstruction) however some patients with acute obstruction have little or no dilationIn particular US is helpful in evaluating those with renal insufficiency or contraindications for the use of contrast media however US is often skipped in favor of nonenhanced CTIn addition US is good for characterizing lucent filling defects that are visualized as stones on IVU However US does not provide direct physiologic information regarding the degree of obstruction Doppler imaging may demonstrate a high resistive index in acute obstruction but this may not occur immediately or after forniceal rupture Absence of the ureteral jet as visualized with color Doppler on the symptomatic side is presumptive evidence for a high-grade obstruction in a well-hydrated patient

Degree of confidenceUS is very insensitive for stones especially stones smaller than 2 mm stones at the UPJ or stones in the mid ureter Fowler et al suggest that US has a sensitivity as low as 24 compared with nonenhanced CT Furthermore estimations of stone size may not be accurate Compared with nonenhanced CT US is more dependent on the operators ability and more time consuming

False positivesnegativesUS is fairly specific when stones are seen with a specificity as high as 90 With US matrix or indinavir stones may have soft tissue echogenicity without shadowing False-positive findings may result from renal vascular calcifications False-positive diagnoses of hydronephrosis also result from dilated vascular structures in the renal hilum Doppler imaging is helpful in distinguishing dilated vascular structures from hydronephrosis

Renal sonogram demonstrates an echogenic shadowing calculus in the renal collecting system with hydronephrosis

US images for renal stones

US images of staghorn stones

US images for ureteric stones

US images for nephrocalcinosis

Renal cystA renal cyst is a fluid collection in the kidney There are several types based on the Bosniak classification The majority are benign simple cysts that can be monitored and not intervened upon However some are cancerous or are suspicious for cancer and are commonly removed in a surgical procedure called nephrectomyNumerous renal cysts are seen in the cystic kidney diseases which include polycystic kidney diseaseand medullary sponge kidney

The Bosniak classification categorizes renal cysts into five groupsCategory I

Benign simple cyst with thin wall without septa calcifications or solid

components

It does not enhance with contrast and has a density equal to that of water

Category IIBenign cyst with a few thin septa which may contain fine calcifications or a

small

segment of mildly thickened calcification This includes homogenous

high-attenuation lesions less than 3 cm with sharp margins(Rich Kosak) but

without enhancement

Category IIFWell marginated cysts with a number of thin septa with or without mild

enhancement or thickening of septa Calcifications may be present these

may be thick and nodular There are no enhancing soft tissue components

This also includes nonenhancing high-attenuation lesions that are completely

contained within the kidney and are 3 cm or larger

Category IIIIndeterminate cystic masses with thickened irregular septa with enhancement

Category IVMalignant cystic masses with all the characteristics of category III lesions

but also with enhancing soft tissue components independent of but adjacent

to the septa

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 11)

Classic findings of a simple cyst(Bosniak category 111)

Classic findings of a simple cyst(Bosniak category 1V)

Para-pelvic cyst USamp CT images

US of polycystic kidney disease

Renal infection

US of acute pyelonephritis

Acute bacterial pyelonephritis (a) US scan shows a wedge-shaped hyperechoic focus (arrowhead) in the upper pole of the right kidney related to acute bacterial pyelonephritis (b) Color flow US image demonstrates diminished flow through the involved area

US and color Doppler images of right kidney shows focal hyperechoic nephritis with decreased perfusion at the Doppler US

US and color Doppler images of kidney shows two multifocal nephritis with decreased perfusion at the Doppler US

Masslike appearance of acute bacterial pyelonephritis US and CT images

Emphysematous pyelonephritis (a) US image shows nondependent echoes within the left kidney that demonstrate a ring-down artifact (b) Corresponding CT scan helps confirm that this pattern is caused by intraparenchymal air

Xanthogranulomatous pyelonephritis (a) Contrast-enhanced CT scan demonstrates bilateral staghorn calculi with distention of the right collecting system secondary to inflammatory debris (b) US scan also shows the dilated

collecting system (arrowheads) and a shadowing calculus (arrow)

Early and mature abscess cavities (a) US scan demonstrates a geographic hypoechoic focus from an abscess in the upper pole of the right kidney (b) On a US scan of a more mature abscess the cavity is better defined with a visible pseudocapsule and through transmission that is evidenced by increased echogenicity deep to the upper pole lesion

Pyohydronephrosis

Pyohydronephrosis

Renal hydatidosis is an insidious disease and patients

often present with nonspecific clinical signs or symptoms Presenting complaints are dull flank pain hematuria palpable flank mass hypertension and renal colic

Disseminated abdominal retroperitoneal and pelvic hydatid disease (a) The right kidney is pushed to the midline and the left kidney is hydronephrotic and shrunken by retroperitoneal hydatid cysts (b) Ultrasound of the abdomen showing cystic lesions in the retroperitoneum in the position of the kidneys

Hydatid disease of the kidney US and CT images

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 25: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Transverse scan shows a metastasis with a complex echo structure ldquowedgedrdquo between right lobe of the liver inferior vena cava the kidney and spinal column

Transverse scan of a metastasis of the right adrenal gland with complex structure beside a primary tumour of lung cancer

Partial metastases esp of lung cancer show

a wash out of contrast media in late phase

US examination longitudinal view Above the right kidney in the adrenal region a solid slightly inhomogeneous mass can be seen Neuroblastoma MRI examination

axial T2 weighted image Irregular large solid inhomogeneous retroperitoneal tumor

Pheochromocytoma Pheochromocytoma is a tumour of the adrenal medulla that is generally

detected sonographically (80ndash90 of cases) following the appearance

of clinical symptoms (hypertension and tachycardia caused by

increased catecholamine secretion)

Most pheochromocytomas are already several centimeters in diameter

when diagnosed They have smooth margins a round shape and a

nonhomogeneous or complex echo structure

Hypoechoic liquid components are also observed A spectrum of

appearances may be seen Pheochromocytomas are bilateral in

approximately 10 of cases and extra-adrenal in 10ndash20

The ldquoZuckerkandl organrdquo should be looked for at the level of the origin

of the inferior mesenteric artery anterior to the aorta

Other extra-adrenal sites are the renal hilum bladder wall and thorax

Pheochromocytoma is occasionally seen posterior to the renal vein in

transverse scans Rarely pheochromocytoma is diagnosed in the

setting of multiple endocrine neoplasia (MEN) From 2 to 5 of

pheochromocytomas are malignant Owing to the risk of inciting a

hypertensive crisis fine-needle aspiration biopsy causes discrepant

discussions about FNB

Nonhomogeneous tumour with a hyperechoic center (positive endocrine test increased catecholamine secretion) ndash Pheochromocytoma

Large functionally active pheochromocytoma (7 cm in diameter) The scan shows that most of tumour is hypoechoic with some hyperechoic regions

Lymphoma The adrenal region is a rare extranodal site of occurrence for lymphoma

Foci of lymphomatous infiltration have smooth borders and are

hypoechoic Differentiation is required from lymphomas in the renal or

splenic hilum If invasion by lymphoma is suspected other nodal

stations should be scanned and commonly infiltrated organs (spleen

liver) should be closely scrutinized

Perisplenic lymphoma in the left adrenal region of a patient with B-cell lymphoma

Colour Doppler shows hypervascularisation of the lymphatic tissue

Adrenal Carcinoma Adrenal carcinoma is usually inhomogeneous hypoechoic or echo complex with irregular margins It frequently infiltrates its surroundings and metastases can be demonstrated in the adrenal region and in other organs (eg the liver) The adrenal carcinoma is a very rare (1 17 million inhabitants) highly malignant tumour with a poor prognosis Adrenal carcinoma is indistinguishable sonographically from a metastasis although the visualization of additional tumours can advance the differential diagnosis Most adrenal carcinomas are hormone-producing Sometimes one can get evidence from detection of other tumour sign The tumour is usually detected only after it has reached considerable size (often gt8 cm) Intratumoral hemorrhage necrotic foci and calcifications may occur adding to the variegated appearance

Adrenal carcinoma may be hypoechoic or may have a complex echo structure Usually it

was relatively large when diagnosed (in this case 8 cm times 9 cm) and had irregular margins

Right adrenal adenocarcinoma A Sonogram showing a complex mass with cystic changes in the right adrenal gland (arrows) B Computed tomogram showing the mass (arrows)

Incidentaloma An incidentaloma is an adrenal tumour that is detected incidentally in an asymptomatic patient Incidentalomas are found in 1 of CT examinations They are much less common in ultrasound examinations because of the difficulty in defining small lesions (lt 2 cm) The predominantly hypoechoic tumours account for the great majority of incidentalomas shows the algorithm used in the investigation of incidentalomas Approximately 10 to 15 of these tumours are hormonally active In some cases ultrasound-guided fine-needle aspiration can also aid in the evaluation of incidentalomas but only ca 1 to 2 of these tumours are malignant

Abdominal ultrasound examination incidentally found most hypoechoic lesions

smaller 2 cm without clinical symptoms ndash which is typical for incidentalomas

Histoplasmosis is a geographically restricted form of

fungal infection Adrenal involvement is seen in disseminated disease but sometimes it may be the only site of demonstrable disease Early diagnosis and treatment may save the patient from catastrophic adrenal insufficiency We present two patients showing bilateral adrenomegaly on ultrasonography and contrast-enhanced CT and was diagnosed to have histoplasmosis on fine-needle aspiration cytology

Histoplasmosis is an infective condition caused by a

dimorphic saprophytic fungus Histoplasma capsulatum and is acquired by inhalation of its spores Soil rich in bird and bat dropping is its natural habitat and it exists as a mycelium in the atmosphere

Both adrenal gland were enlarged and hypoechoic at US study

US show bilateral hypoechoic lesions and CT showed peripherally enhancing hypodense bilateral adrenals with peripheral rim and septate enhancement

ULTRASOUND OF THE ADULT KIDNEY ndash Normal

Coronal scan plane for the Right Kidney Longitudinal Normal Kidney

Scan plane transverse kidney Transverse normal image

Common anatomical variantsAtrophic small kidneyHorseshoe kidneyEctopic kidneyDuplex kidneyCross fused ectopiaUnilateral renal agenesis

COMMON PATHOLOGYCalculusRenal cyst Cortical and Para-pelvicAngiomyolipmaRenal infectionRenal cell carcinomaTransitional cell carcinomaMedullary sponge kidneyPolycystic kidney disease

Horseshoe kidney A transverse and longitudinal view across the midline showing the isthmus across the aorta

Cross fused ectopic kidney The left kidney is fused to the lower pole of the right kidney

A baggy extra-renal pelvis

Pelvic ectopic kidney

UltrasonographyOn sonograms stones are demonstrated as bright echogenic foci with posterior acoustic shadowing Stones are visualized fairly well with US in the kidneys and the distal ureter at or near the UVJ especially if dilatation is present US is good for the visualization of complications such as hydronephrosis (or other signs of obstruction) however some patients with acute obstruction have little or no dilationIn particular US is helpful in evaluating those with renal insufficiency or contraindications for the use of contrast media however US is often skipped in favor of nonenhanced CTIn addition US is good for characterizing lucent filling defects that are visualized as stones on IVU However US does not provide direct physiologic information regarding the degree of obstruction Doppler imaging may demonstrate a high resistive index in acute obstruction but this may not occur immediately or after forniceal rupture Absence of the ureteral jet as visualized with color Doppler on the symptomatic side is presumptive evidence for a high-grade obstruction in a well-hydrated patient

Degree of confidenceUS is very insensitive for stones especially stones smaller than 2 mm stones at the UPJ or stones in the mid ureter Fowler et al suggest that US has a sensitivity as low as 24 compared with nonenhanced CT Furthermore estimations of stone size may not be accurate Compared with nonenhanced CT US is more dependent on the operators ability and more time consuming

False positivesnegativesUS is fairly specific when stones are seen with a specificity as high as 90 With US matrix or indinavir stones may have soft tissue echogenicity without shadowing False-positive findings may result from renal vascular calcifications False-positive diagnoses of hydronephrosis also result from dilated vascular structures in the renal hilum Doppler imaging is helpful in distinguishing dilated vascular structures from hydronephrosis

Renal sonogram demonstrates an echogenic shadowing calculus in the renal collecting system with hydronephrosis

US images for renal stones

US images of staghorn stones

US images for ureteric stones

US images for nephrocalcinosis

Renal cystA renal cyst is a fluid collection in the kidney There are several types based on the Bosniak classification The majority are benign simple cysts that can be monitored and not intervened upon However some are cancerous or are suspicious for cancer and are commonly removed in a surgical procedure called nephrectomyNumerous renal cysts are seen in the cystic kidney diseases which include polycystic kidney diseaseand medullary sponge kidney

The Bosniak classification categorizes renal cysts into five groupsCategory I

Benign simple cyst with thin wall without septa calcifications or solid

components

It does not enhance with contrast and has a density equal to that of water

Category IIBenign cyst with a few thin septa which may contain fine calcifications or a

small

segment of mildly thickened calcification This includes homogenous

high-attenuation lesions less than 3 cm with sharp margins(Rich Kosak) but

without enhancement

Category IIFWell marginated cysts with a number of thin septa with or without mild

enhancement or thickening of septa Calcifications may be present these

may be thick and nodular There are no enhancing soft tissue components

This also includes nonenhancing high-attenuation lesions that are completely

contained within the kidney and are 3 cm or larger

Category IIIIndeterminate cystic masses with thickened irregular septa with enhancement

Category IVMalignant cystic masses with all the characteristics of category III lesions

but also with enhancing soft tissue components independent of but adjacent

to the septa

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 11)

Classic findings of a simple cyst(Bosniak category 111)

Classic findings of a simple cyst(Bosniak category 1V)

Para-pelvic cyst USamp CT images

US of polycystic kidney disease

Renal infection

US of acute pyelonephritis

Acute bacterial pyelonephritis (a) US scan shows a wedge-shaped hyperechoic focus (arrowhead) in the upper pole of the right kidney related to acute bacterial pyelonephritis (b) Color flow US image demonstrates diminished flow through the involved area

US and color Doppler images of right kidney shows focal hyperechoic nephritis with decreased perfusion at the Doppler US

US and color Doppler images of kidney shows two multifocal nephritis with decreased perfusion at the Doppler US

Masslike appearance of acute bacterial pyelonephritis US and CT images

Emphysematous pyelonephritis (a) US image shows nondependent echoes within the left kidney that demonstrate a ring-down artifact (b) Corresponding CT scan helps confirm that this pattern is caused by intraparenchymal air

Xanthogranulomatous pyelonephritis (a) Contrast-enhanced CT scan demonstrates bilateral staghorn calculi with distention of the right collecting system secondary to inflammatory debris (b) US scan also shows the dilated

collecting system (arrowheads) and a shadowing calculus (arrow)

Early and mature abscess cavities (a) US scan demonstrates a geographic hypoechoic focus from an abscess in the upper pole of the right kidney (b) On a US scan of a more mature abscess the cavity is better defined with a visible pseudocapsule and through transmission that is evidenced by increased echogenicity deep to the upper pole lesion

Pyohydronephrosis

Pyohydronephrosis

Renal hydatidosis is an insidious disease and patients

often present with nonspecific clinical signs or symptoms Presenting complaints are dull flank pain hematuria palpable flank mass hypertension and renal colic

Disseminated abdominal retroperitoneal and pelvic hydatid disease (a) The right kidney is pushed to the midline and the left kidney is hydronephrotic and shrunken by retroperitoneal hydatid cysts (b) Ultrasound of the abdomen showing cystic lesions in the retroperitoneum in the position of the kidneys

Hydatid disease of the kidney US and CT images

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 26: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Transverse scan of a metastasis of the right adrenal gland with complex structure beside a primary tumour of lung cancer

Partial metastases esp of lung cancer show

a wash out of contrast media in late phase

US examination longitudinal view Above the right kidney in the adrenal region a solid slightly inhomogeneous mass can be seen Neuroblastoma MRI examination

axial T2 weighted image Irregular large solid inhomogeneous retroperitoneal tumor

Pheochromocytoma Pheochromocytoma is a tumour of the adrenal medulla that is generally

detected sonographically (80ndash90 of cases) following the appearance

of clinical symptoms (hypertension and tachycardia caused by

increased catecholamine secretion)

Most pheochromocytomas are already several centimeters in diameter

when diagnosed They have smooth margins a round shape and a

nonhomogeneous or complex echo structure

Hypoechoic liquid components are also observed A spectrum of

appearances may be seen Pheochromocytomas are bilateral in

approximately 10 of cases and extra-adrenal in 10ndash20

The ldquoZuckerkandl organrdquo should be looked for at the level of the origin

of the inferior mesenteric artery anterior to the aorta

Other extra-adrenal sites are the renal hilum bladder wall and thorax

Pheochromocytoma is occasionally seen posterior to the renal vein in

transverse scans Rarely pheochromocytoma is diagnosed in the

setting of multiple endocrine neoplasia (MEN) From 2 to 5 of

pheochromocytomas are malignant Owing to the risk of inciting a

hypertensive crisis fine-needle aspiration biopsy causes discrepant

discussions about FNB

Nonhomogeneous tumour with a hyperechoic center (positive endocrine test increased catecholamine secretion) ndash Pheochromocytoma

Large functionally active pheochromocytoma (7 cm in diameter) The scan shows that most of tumour is hypoechoic with some hyperechoic regions

Lymphoma The adrenal region is a rare extranodal site of occurrence for lymphoma

Foci of lymphomatous infiltration have smooth borders and are

hypoechoic Differentiation is required from lymphomas in the renal or

splenic hilum If invasion by lymphoma is suspected other nodal

stations should be scanned and commonly infiltrated organs (spleen

liver) should be closely scrutinized

Perisplenic lymphoma in the left adrenal region of a patient with B-cell lymphoma

Colour Doppler shows hypervascularisation of the lymphatic tissue

Adrenal Carcinoma Adrenal carcinoma is usually inhomogeneous hypoechoic or echo complex with irregular margins It frequently infiltrates its surroundings and metastases can be demonstrated in the adrenal region and in other organs (eg the liver) The adrenal carcinoma is a very rare (1 17 million inhabitants) highly malignant tumour with a poor prognosis Adrenal carcinoma is indistinguishable sonographically from a metastasis although the visualization of additional tumours can advance the differential diagnosis Most adrenal carcinomas are hormone-producing Sometimes one can get evidence from detection of other tumour sign The tumour is usually detected only after it has reached considerable size (often gt8 cm) Intratumoral hemorrhage necrotic foci and calcifications may occur adding to the variegated appearance

Adrenal carcinoma may be hypoechoic or may have a complex echo structure Usually it

was relatively large when diagnosed (in this case 8 cm times 9 cm) and had irregular margins

Right adrenal adenocarcinoma A Sonogram showing a complex mass with cystic changes in the right adrenal gland (arrows) B Computed tomogram showing the mass (arrows)

Incidentaloma An incidentaloma is an adrenal tumour that is detected incidentally in an asymptomatic patient Incidentalomas are found in 1 of CT examinations They are much less common in ultrasound examinations because of the difficulty in defining small lesions (lt 2 cm) The predominantly hypoechoic tumours account for the great majority of incidentalomas shows the algorithm used in the investigation of incidentalomas Approximately 10 to 15 of these tumours are hormonally active In some cases ultrasound-guided fine-needle aspiration can also aid in the evaluation of incidentalomas but only ca 1 to 2 of these tumours are malignant

Abdominal ultrasound examination incidentally found most hypoechoic lesions

smaller 2 cm without clinical symptoms ndash which is typical for incidentalomas

Histoplasmosis is a geographically restricted form of

fungal infection Adrenal involvement is seen in disseminated disease but sometimes it may be the only site of demonstrable disease Early diagnosis and treatment may save the patient from catastrophic adrenal insufficiency We present two patients showing bilateral adrenomegaly on ultrasonography and contrast-enhanced CT and was diagnosed to have histoplasmosis on fine-needle aspiration cytology

Histoplasmosis is an infective condition caused by a

dimorphic saprophytic fungus Histoplasma capsulatum and is acquired by inhalation of its spores Soil rich in bird and bat dropping is its natural habitat and it exists as a mycelium in the atmosphere

Both adrenal gland were enlarged and hypoechoic at US study

US show bilateral hypoechoic lesions and CT showed peripherally enhancing hypodense bilateral adrenals with peripheral rim and septate enhancement

ULTRASOUND OF THE ADULT KIDNEY ndash Normal

Coronal scan plane for the Right Kidney Longitudinal Normal Kidney

Scan plane transverse kidney Transverse normal image

Common anatomical variantsAtrophic small kidneyHorseshoe kidneyEctopic kidneyDuplex kidneyCross fused ectopiaUnilateral renal agenesis

COMMON PATHOLOGYCalculusRenal cyst Cortical and Para-pelvicAngiomyolipmaRenal infectionRenal cell carcinomaTransitional cell carcinomaMedullary sponge kidneyPolycystic kidney disease

Horseshoe kidney A transverse and longitudinal view across the midline showing the isthmus across the aorta

Cross fused ectopic kidney The left kidney is fused to the lower pole of the right kidney

A baggy extra-renal pelvis

Pelvic ectopic kidney

UltrasonographyOn sonograms stones are demonstrated as bright echogenic foci with posterior acoustic shadowing Stones are visualized fairly well with US in the kidneys and the distal ureter at or near the UVJ especially if dilatation is present US is good for the visualization of complications such as hydronephrosis (or other signs of obstruction) however some patients with acute obstruction have little or no dilationIn particular US is helpful in evaluating those with renal insufficiency or contraindications for the use of contrast media however US is often skipped in favor of nonenhanced CTIn addition US is good for characterizing lucent filling defects that are visualized as stones on IVU However US does not provide direct physiologic information regarding the degree of obstruction Doppler imaging may demonstrate a high resistive index in acute obstruction but this may not occur immediately or after forniceal rupture Absence of the ureteral jet as visualized with color Doppler on the symptomatic side is presumptive evidence for a high-grade obstruction in a well-hydrated patient

Degree of confidenceUS is very insensitive for stones especially stones smaller than 2 mm stones at the UPJ or stones in the mid ureter Fowler et al suggest that US has a sensitivity as low as 24 compared with nonenhanced CT Furthermore estimations of stone size may not be accurate Compared with nonenhanced CT US is more dependent on the operators ability and more time consuming

False positivesnegativesUS is fairly specific when stones are seen with a specificity as high as 90 With US matrix or indinavir stones may have soft tissue echogenicity without shadowing False-positive findings may result from renal vascular calcifications False-positive diagnoses of hydronephrosis also result from dilated vascular structures in the renal hilum Doppler imaging is helpful in distinguishing dilated vascular structures from hydronephrosis

Renal sonogram demonstrates an echogenic shadowing calculus in the renal collecting system with hydronephrosis

US images for renal stones

US images of staghorn stones

US images for ureteric stones

US images for nephrocalcinosis

Renal cystA renal cyst is a fluid collection in the kidney There are several types based on the Bosniak classification The majority are benign simple cysts that can be monitored and not intervened upon However some are cancerous or are suspicious for cancer and are commonly removed in a surgical procedure called nephrectomyNumerous renal cysts are seen in the cystic kidney diseases which include polycystic kidney diseaseand medullary sponge kidney

The Bosniak classification categorizes renal cysts into five groupsCategory I

Benign simple cyst with thin wall without septa calcifications or solid

components

It does not enhance with contrast and has a density equal to that of water

Category IIBenign cyst with a few thin septa which may contain fine calcifications or a

small

segment of mildly thickened calcification This includes homogenous

high-attenuation lesions less than 3 cm with sharp margins(Rich Kosak) but

without enhancement

Category IIFWell marginated cysts with a number of thin septa with or without mild

enhancement or thickening of septa Calcifications may be present these

may be thick and nodular There are no enhancing soft tissue components

This also includes nonenhancing high-attenuation lesions that are completely

contained within the kidney and are 3 cm or larger

Category IIIIndeterminate cystic masses with thickened irregular septa with enhancement

Category IVMalignant cystic masses with all the characteristics of category III lesions

but also with enhancing soft tissue components independent of but adjacent

to the septa

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 11)

Classic findings of a simple cyst(Bosniak category 111)

Classic findings of a simple cyst(Bosniak category 1V)

Para-pelvic cyst USamp CT images

US of polycystic kidney disease

Renal infection

US of acute pyelonephritis

Acute bacterial pyelonephritis (a) US scan shows a wedge-shaped hyperechoic focus (arrowhead) in the upper pole of the right kidney related to acute bacterial pyelonephritis (b) Color flow US image demonstrates diminished flow through the involved area

US and color Doppler images of right kidney shows focal hyperechoic nephritis with decreased perfusion at the Doppler US

US and color Doppler images of kidney shows two multifocal nephritis with decreased perfusion at the Doppler US

Masslike appearance of acute bacterial pyelonephritis US and CT images

Emphysematous pyelonephritis (a) US image shows nondependent echoes within the left kidney that demonstrate a ring-down artifact (b) Corresponding CT scan helps confirm that this pattern is caused by intraparenchymal air

Xanthogranulomatous pyelonephritis (a) Contrast-enhanced CT scan demonstrates bilateral staghorn calculi with distention of the right collecting system secondary to inflammatory debris (b) US scan also shows the dilated

collecting system (arrowheads) and a shadowing calculus (arrow)

Early and mature abscess cavities (a) US scan demonstrates a geographic hypoechoic focus from an abscess in the upper pole of the right kidney (b) On a US scan of a more mature abscess the cavity is better defined with a visible pseudocapsule and through transmission that is evidenced by increased echogenicity deep to the upper pole lesion

Pyohydronephrosis

Pyohydronephrosis

Renal hydatidosis is an insidious disease and patients

often present with nonspecific clinical signs or symptoms Presenting complaints are dull flank pain hematuria palpable flank mass hypertension and renal colic

Disseminated abdominal retroperitoneal and pelvic hydatid disease (a) The right kidney is pushed to the midline and the left kidney is hydronephrotic and shrunken by retroperitoneal hydatid cysts (b) Ultrasound of the abdomen showing cystic lesions in the retroperitoneum in the position of the kidneys

Hydatid disease of the kidney US and CT images

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 27: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Partial metastases esp of lung cancer show

a wash out of contrast media in late phase

US examination longitudinal view Above the right kidney in the adrenal region a solid slightly inhomogeneous mass can be seen Neuroblastoma MRI examination

axial T2 weighted image Irregular large solid inhomogeneous retroperitoneal tumor

Pheochromocytoma Pheochromocytoma is a tumour of the adrenal medulla that is generally

detected sonographically (80ndash90 of cases) following the appearance

of clinical symptoms (hypertension and tachycardia caused by

increased catecholamine secretion)

Most pheochromocytomas are already several centimeters in diameter

when diagnosed They have smooth margins a round shape and a

nonhomogeneous or complex echo structure

Hypoechoic liquid components are also observed A spectrum of

appearances may be seen Pheochromocytomas are bilateral in

approximately 10 of cases and extra-adrenal in 10ndash20

The ldquoZuckerkandl organrdquo should be looked for at the level of the origin

of the inferior mesenteric artery anterior to the aorta

Other extra-adrenal sites are the renal hilum bladder wall and thorax

Pheochromocytoma is occasionally seen posterior to the renal vein in

transverse scans Rarely pheochromocytoma is diagnosed in the

setting of multiple endocrine neoplasia (MEN) From 2 to 5 of

pheochromocytomas are malignant Owing to the risk of inciting a

hypertensive crisis fine-needle aspiration biopsy causes discrepant

discussions about FNB

Nonhomogeneous tumour with a hyperechoic center (positive endocrine test increased catecholamine secretion) ndash Pheochromocytoma

Large functionally active pheochromocytoma (7 cm in diameter) The scan shows that most of tumour is hypoechoic with some hyperechoic regions

Lymphoma The adrenal region is a rare extranodal site of occurrence for lymphoma

Foci of lymphomatous infiltration have smooth borders and are

hypoechoic Differentiation is required from lymphomas in the renal or

splenic hilum If invasion by lymphoma is suspected other nodal

stations should be scanned and commonly infiltrated organs (spleen

liver) should be closely scrutinized

Perisplenic lymphoma in the left adrenal region of a patient with B-cell lymphoma

Colour Doppler shows hypervascularisation of the lymphatic tissue

Adrenal Carcinoma Adrenal carcinoma is usually inhomogeneous hypoechoic or echo complex with irregular margins It frequently infiltrates its surroundings and metastases can be demonstrated in the adrenal region and in other organs (eg the liver) The adrenal carcinoma is a very rare (1 17 million inhabitants) highly malignant tumour with a poor prognosis Adrenal carcinoma is indistinguishable sonographically from a metastasis although the visualization of additional tumours can advance the differential diagnosis Most adrenal carcinomas are hormone-producing Sometimes one can get evidence from detection of other tumour sign The tumour is usually detected only after it has reached considerable size (often gt8 cm) Intratumoral hemorrhage necrotic foci and calcifications may occur adding to the variegated appearance

Adrenal carcinoma may be hypoechoic or may have a complex echo structure Usually it

was relatively large when diagnosed (in this case 8 cm times 9 cm) and had irregular margins

Right adrenal adenocarcinoma A Sonogram showing a complex mass with cystic changes in the right adrenal gland (arrows) B Computed tomogram showing the mass (arrows)

Incidentaloma An incidentaloma is an adrenal tumour that is detected incidentally in an asymptomatic patient Incidentalomas are found in 1 of CT examinations They are much less common in ultrasound examinations because of the difficulty in defining small lesions (lt 2 cm) The predominantly hypoechoic tumours account for the great majority of incidentalomas shows the algorithm used in the investigation of incidentalomas Approximately 10 to 15 of these tumours are hormonally active In some cases ultrasound-guided fine-needle aspiration can also aid in the evaluation of incidentalomas but only ca 1 to 2 of these tumours are malignant

Abdominal ultrasound examination incidentally found most hypoechoic lesions

smaller 2 cm without clinical symptoms ndash which is typical for incidentalomas

Histoplasmosis is a geographically restricted form of

fungal infection Adrenal involvement is seen in disseminated disease but sometimes it may be the only site of demonstrable disease Early diagnosis and treatment may save the patient from catastrophic adrenal insufficiency We present two patients showing bilateral adrenomegaly on ultrasonography and contrast-enhanced CT and was diagnosed to have histoplasmosis on fine-needle aspiration cytology

Histoplasmosis is an infective condition caused by a

dimorphic saprophytic fungus Histoplasma capsulatum and is acquired by inhalation of its spores Soil rich in bird and bat dropping is its natural habitat and it exists as a mycelium in the atmosphere

Both adrenal gland were enlarged and hypoechoic at US study

US show bilateral hypoechoic lesions and CT showed peripherally enhancing hypodense bilateral adrenals with peripheral rim and septate enhancement

ULTRASOUND OF THE ADULT KIDNEY ndash Normal

Coronal scan plane for the Right Kidney Longitudinal Normal Kidney

Scan plane transverse kidney Transverse normal image

Common anatomical variantsAtrophic small kidneyHorseshoe kidneyEctopic kidneyDuplex kidneyCross fused ectopiaUnilateral renal agenesis

COMMON PATHOLOGYCalculusRenal cyst Cortical and Para-pelvicAngiomyolipmaRenal infectionRenal cell carcinomaTransitional cell carcinomaMedullary sponge kidneyPolycystic kidney disease

Horseshoe kidney A transverse and longitudinal view across the midline showing the isthmus across the aorta

Cross fused ectopic kidney The left kidney is fused to the lower pole of the right kidney

A baggy extra-renal pelvis

Pelvic ectopic kidney

UltrasonographyOn sonograms stones are demonstrated as bright echogenic foci with posterior acoustic shadowing Stones are visualized fairly well with US in the kidneys and the distal ureter at or near the UVJ especially if dilatation is present US is good for the visualization of complications such as hydronephrosis (or other signs of obstruction) however some patients with acute obstruction have little or no dilationIn particular US is helpful in evaluating those with renal insufficiency or contraindications for the use of contrast media however US is often skipped in favor of nonenhanced CTIn addition US is good for characterizing lucent filling defects that are visualized as stones on IVU However US does not provide direct physiologic information regarding the degree of obstruction Doppler imaging may demonstrate a high resistive index in acute obstruction but this may not occur immediately or after forniceal rupture Absence of the ureteral jet as visualized with color Doppler on the symptomatic side is presumptive evidence for a high-grade obstruction in a well-hydrated patient

Degree of confidenceUS is very insensitive for stones especially stones smaller than 2 mm stones at the UPJ or stones in the mid ureter Fowler et al suggest that US has a sensitivity as low as 24 compared with nonenhanced CT Furthermore estimations of stone size may not be accurate Compared with nonenhanced CT US is more dependent on the operators ability and more time consuming

False positivesnegativesUS is fairly specific when stones are seen with a specificity as high as 90 With US matrix or indinavir stones may have soft tissue echogenicity without shadowing False-positive findings may result from renal vascular calcifications False-positive diagnoses of hydronephrosis also result from dilated vascular structures in the renal hilum Doppler imaging is helpful in distinguishing dilated vascular structures from hydronephrosis

Renal sonogram demonstrates an echogenic shadowing calculus in the renal collecting system with hydronephrosis

US images for renal stones

US images of staghorn stones

US images for ureteric stones

US images for nephrocalcinosis

Renal cystA renal cyst is a fluid collection in the kidney There are several types based on the Bosniak classification The majority are benign simple cysts that can be monitored and not intervened upon However some are cancerous or are suspicious for cancer and are commonly removed in a surgical procedure called nephrectomyNumerous renal cysts are seen in the cystic kidney diseases which include polycystic kidney diseaseand medullary sponge kidney

The Bosniak classification categorizes renal cysts into five groupsCategory I

Benign simple cyst with thin wall without septa calcifications or solid

components

It does not enhance with contrast and has a density equal to that of water

Category IIBenign cyst with a few thin septa which may contain fine calcifications or a

small

segment of mildly thickened calcification This includes homogenous

high-attenuation lesions less than 3 cm with sharp margins(Rich Kosak) but

without enhancement

Category IIFWell marginated cysts with a number of thin septa with or without mild

enhancement or thickening of septa Calcifications may be present these

may be thick and nodular There are no enhancing soft tissue components

This also includes nonenhancing high-attenuation lesions that are completely

contained within the kidney and are 3 cm or larger

Category IIIIndeterminate cystic masses with thickened irregular septa with enhancement

Category IVMalignant cystic masses with all the characteristics of category III lesions

but also with enhancing soft tissue components independent of but adjacent

to the septa

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 11)

Classic findings of a simple cyst(Bosniak category 111)

Classic findings of a simple cyst(Bosniak category 1V)

Para-pelvic cyst USamp CT images

US of polycystic kidney disease

Renal infection

US of acute pyelonephritis

Acute bacterial pyelonephritis (a) US scan shows a wedge-shaped hyperechoic focus (arrowhead) in the upper pole of the right kidney related to acute bacterial pyelonephritis (b) Color flow US image demonstrates diminished flow through the involved area

US and color Doppler images of right kidney shows focal hyperechoic nephritis with decreased perfusion at the Doppler US

US and color Doppler images of kidney shows two multifocal nephritis with decreased perfusion at the Doppler US

Masslike appearance of acute bacterial pyelonephritis US and CT images

Emphysematous pyelonephritis (a) US image shows nondependent echoes within the left kidney that demonstrate a ring-down artifact (b) Corresponding CT scan helps confirm that this pattern is caused by intraparenchymal air

Xanthogranulomatous pyelonephritis (a) Contrast-enhanced CT scan demonstrates bilateral staghorn calculi with distention of the right collecting system secondary to inflammatory debris (b) US scan also shows the dilated

collecting system (arrowheads) and a shadowing calculus (arrow)

Early and mature abscess cavities (a) US scan demonstrates a geographic hypoechoic focus from an abscess in the upper pole of the right kidney (b) On a US scan of a more mature abscess the cavity is better defined with a visible pseudocapsule and through transmission that is evidenced by increased echogenicity deep to the upper pole lesion

Pyohydronephrosis

Pyohydronephrosis

Renal hydatidosis is an insidious disease and patients

often present with nonspecific clinical signs or symptoms Presenting complaints are dull flank pain hematuria palpable flank mass hypertension and renal colic

Disseminated abdominal retroperitoneal and pelvic hydatid disease (a) The right kidney is pushed to the midline and the left kidney is hydronephrotic and shrunken by retroperitoneal hydatid cysts (b) Ultrasound of the abdomen showing cystic lesions in the retroperitoneum in the position of the kidneys

Hydatid disease of the kidney US and CT images

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 28: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

US examination longitudinal view Above the right kidney in the adrenal region a solid slightly inhomogeneous mass can be seen Neuroblastoma MRI examination

axial T2 weighted image Irregular large solid inhomogeneous retroperitoneal tumor

Pheochromocytoma Pheochromocytoma is a tumour of the adrenal medulla that is generally

detected sonographically (80ndash90 of cases) following the appearance

of clinical symptoms (hypertension and tachycardia caused by

increased catecholamine secretion)

Most pheochromocytomas are already several centimeters in diameter

when diagnosed They have smooth margins a round shape and a

nonhomogeneous or complex echo structure

Hypoechoic liquid components are also observed A spectrum of

appearances may be seen Pheochromocytomas are bilateral in

approximately 10 of cases and extra-adrenal in 10ndash20

The ldquoZuckerkandl organrdquo should be looked for at the level of the origin

of the inferior mesenteric artery anterior to the aorta

Other extra-adrenal sites are the renal hilum bladder wall and thorax

Pheochromocytoma is occasionally seen posterior to the renal vein in

transverse scans Rarely pheochromocytoma is diagnosed in the

setting of multiple endocrine neoplasia (MEN) From 2 to 5 of

pheochromocytomas are malignant Owing to the risk of inciting a

hypertensive crisis fine-needle aspiration biopsy causes discrepant

discussions about FNB

Nonhomogeneous tumour with a hyperechoic center (positive endocrine test increased catecholamine secretion) ndash Pheochromocytoma

Large functionally active pheochromocytoma (7 cm in diameter) The scan shows that most of tumour is hypoechoic with some hyperechoic regions

Lymphoma The adrenal region is a rare extranodal site of occurrence for lymphoma

Foci of lymphomatous infiltration have smooth borders and are

hypoechoic Differentiation is required from lymphomas in the renal or

splenic hilum If invasion by lymphoma is suspected other nodal

stations should be scanned and commonly infiltrated organs (spleen

liver) should be closely scrutinized

Perisplenic lymphoma in the left adrenal region of a patient with B-cell lymphoma

Colour Doppler shows hypervascularisation of the lymphatic tissue

Adrenal Carcinoma Adrenal carcinoma is usually inhomogeneous hypoechoic or echo complex with irregular margins It frequently infiltrates its surroundings and metastases can be demonstrated in the adrenal region and in other organs (eg the liver) The adrenal carcinoma is a very rare (1 17 million inhabitants) highly malignant tumour with a poor prognosis Adrenal carcinoma is indistinguishable sonographically from a metastasis although the visualization of additional tumours can advance the differential diagnosis Most adrenal carcinomas are hormone-producing Sometimes one can get evidence from detection of other tumour sign The tumour is usually detected only after it has reached considerable size (often gt8 cm) Intratumoral hemorrhage necrotic foci and calcifications may occur adding to the variegated appearance

Adrenal carcinoma may be hypoechoic or may have a complex echo structure Usually it

was relatively large when diagnosed (in this case 8 cm times 9 cm) and had irregular margins

Right adrenal adenocarcinoma A Sonogram showing a complex mass with cystic changes in the right adrenal gland (arrows) B Computed tomogram showing the mass (arrows)

Incidentaloma An incidentaloma is an adrenal tumour that is detected incidentally in an asymptomatic patient Incidentalomas are found in 1 of CT examinations They are much less common in ultrasound examinations because of the difficulty in defining small lesions (lt 2 cm) The predominantly hypoechoic tumours account for the great majority of incidentalomas shows the algorithm used in the investigation of incidentalomas Approximately 10 to 15 of these tumours are hormonally active In some cases ultrasound-guided fine-needle aspiration can also aid in the evaluation of incidentalomas but only ca 1 to 2 of these tumours are malignant

Abdominal ultrasound examination incidentally found most hypoechoic lesions

smaller 2 cm without clinical symptoms ndash which is typical for incidentalomas

Histoplasmosis is a geographically restricted form of

fungal infection Adrenal involvement is seen in disseminated disease but sometimes it may be the only site of demonstrable disease Early diagnosis and treatment may save the patient from catastrophic adrenal insufficiency We present two patients showing bilateral adrenomegaly on ultrasonography and contrast-enhanced CT and was diagnosed to have histoplasmosis on fine-needle aspiration cytology

Histoplasmosis is an infective condition caused by a

dimorphic saprophytic fungus Histoplasma capsulatum and is acquired by inhalation of its spores Soil rich in bird and bat dropping is its natural habitat and it exists as a mycelium in the atmosphere

Both adrenal gland were enlarged and hypoechoic at US study

US show bilateral hypoechoic lesions and CT showed peripherally enhancing hypodense bilateral adrenals with peripheral rim and septate enhancement

ULTRASOUND OF THE ADULT KIDNEY ndash Normal

Coronal scan plane for the Right Kidney Longitudinal Normal Kidney

Scan plane transverse kidney Transverse normal image

Common anatomical variantsAtrophic small kidneyHorseshoe kidneyEctopic kidneyDuplex kidneyCross fused ectopiaUnilateral renal agenesis

COMMON PATHOLOGYCalculusRenal cyst Cortical and Para-pelvicAngiomyolipmaRenal infectionRenal cell carcinomaTransitional cell carcinomaMedullary sponge kidneyPolycystic kidney disease

Horseshoe kidney A transverse and longitudinal view across the midline showing the isthmus across the aorta

Cross fused ectopic kidney The left kidney is fused to the lower pole of the right kidney

A baggy extra-renal pelvis

Pelvic ectopic kidney

UltrasonographyOn sonograms stones are demonstrated as bright echogenic foci with posterior acoustic shadowing Stones are visualized fairly well with US in the kidneys and the distal ureter at or near the UVJ especially if dilatation is present US is good for the visualization of complications such as hydronephrosis (or other signs of obstruction) however some patients with acute obstruction have little or no dilationIn particular US is helpful in evaluating those with renal insufficiency or contraindications for the use of contrast media however US is often skipped in favor of nonenhanced CTIn addition US is good for characterizing lucent filling defects that are visualized as stones on IVU However US does not provide direct physiologic information regarding the degree of obstruction Doppler imaging may demonstrate a high resistive index in acute obstruction but this may not occur immediately or after forniceal rupture Absence of the ureteral jet as visualized with color Doppler on the symptomatic side is presumptive evidence for a high-grade obstruction in a well-hydrated patient

Degree of confidenceUS is very insensitive for stones especially stones smaller than 2 mm stones at the UPJ or stones in the mid ureter Fowler et al suggest that US has a sensitivity as low as 24 compared with nonenhanced CT Furthermore estimations of stone size may not be accurate Compared with nonenhanced CT US is more dependent on the operators ability and more time consuming

False positivesnegativesUS is fairly specific when stones are seen with a specificity as high as 90 With US matrix or indinavir stones may have soft tissue echogenicity without shadowing False-positive findings may result from renal vascular calcifications False-positive diagnoses of hydronephrosis also result from dilated vascular structures in the renal hilum Doppler imaging is helpful in distinguishing dilated vascular structures from hydronephrosis

Renal sonogram demonstrates an echogenic shadowing calculus in the renal collecting system with hydronephrosis

US images for renal stones

US images of staghorn stones

US images for ureteric stones

US images for nephrocalcinosis

Renal cystA renal cyst is a fluid collection in the kidney There are several types based on the Bosniak classification The majority are benign simple cysts that can be monitored and not intervened upon However some are cancerous or are suspicious for cancer and are commonly removed in a surgical procedure called nephrectomyNumerous renal cysts are seen in the cystic kidney diseases which include polycystic kidney diseaseand medullary sponge kidney

The Bosniak classification categorizes renal cysts into five groupsCategory I

Benign simple cyst with thin wall without septa calcifications or solid

components

It does not enhance with contrast and has a density equal to that of water

Category IIBenign cyst with a few thin septa which may contain fine calcifications or a

small

segment of mildly thickened calcification This includes homogenous

high-attenuation lesions less than 3 cm with sharp margins(Rich Kosak) but

without enhancement

Category IIFWell marginated cysts with a number of thin septa with or without mild

enhancement or thickening of septa Calcifications may be present these

may be thick and nodular There are no enhancing soft tissue components

This also includes nonenhancing high-attenuation lesions that are completely

contained within the kidney and are 3 cm or larger

Category IIIIndeterminate cystic masses with thickened irregular septa with enhancement

Category IVMalignant cystic masses with all the characteristics of category III lesions

but also with enhancing soft tissue components independent of but adjacent

to the septa

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 11)

Classic findings of a simple cyst(Bosniak category 111)

Classic findings of a simple cyst(Bosniak category 1V)

Para-pelvic cyst USamp CT images

US of polycystic kidney disease

Renal infection

US of acute pyelonephritis

Acute bacterial pyelonephritis (a) US scan shows a wedge-shaped hyperechoic focus (arrowhead) in the upper pole of the right kidney related to acute bacterial pyelonephritis (b) Color flow US image demonstrates diminished flow through the involved area

US and color Doppler images of right kidney shows focal hyperechoic nephritis with decreased perfusion at the Doppler US

US and color Doppler images of kidney shows two multifocal nephritis with decreased perfusion at the Doppler US

Masslike appearance of acute bacterial pyelonephritis US and CT images

Emphysematous pyelonephritis (a) US image shows nondependent echoes within the left kidney that demonstrate a ring-down artifact (b) Corresponding CT scan helps confirm that this pattern is caused by intraparenchymal air

Xanthogranulomatous pyelonephritis (a) Contrast-enhanced CT scan demonstrates bilateral staghorn calculi with distention of the right collecting system secondary to inflammatory debris (b) US scan also shows the dilated

collecting system (arrowheads) and a shadowing calculus (arrow)

Early and mature abscess cavities (a) US scan demonstrates a geographic hypoechoic focus from an abscess in the upper pole of the right kidney (b) On a US scan of a more mature abscess the cavity is better defined with a visible pseudocapsule and through transmission that is evidenced by increased echogenicity deep to the upper pole lesion

Pyohydronephrosis

Pyohydronephrosis

Renal hydatidosis is an insidious disease and patients

often present with nonspecific clinical signs or symptoms Presenting complaints are dull flank pain hematuria palpable flank mass hypertension and renal colic

Disseminated abdominal retroperitoneal and pelvic hydatid disease (a) The right kidney is pushed to the midline and the left kidney is hydronephrotic and shrunken by retroperitoneal hydatid cysts (b) Ultrasound of the abdomen showing cystic lesions in the retroperitoneum in the position of the kidneys

Hydatid disease of the kidney US and CT images

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 29: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Pheochromocytoma Pheochromocytoma is a tumour of the adrenal medulla that is generally

detected sonographically (80ndash90 of cases) following the appearance

of clinical symptoms (hypertension and tachycardia caused by

increased catecholamine secretion)

Most pheochromocytomas are already several centimeters in diameter

when diagnosed They have smooth margins a round shape and a

nonhomogeneous or complex echo structure

Hypoechoic liquid components are also observed A spectrum of

appearances may be seen Pheochromocytomas are bilateral in

approximately 10 of cases and extra-adrenal in 10ndash20

The ldquoZuckerkandl organrdquo should be looked for at the level of the origin

of the inferior mesenteric artery anterior to the aorta

Other extra-adrenal sites are the renal hilum bladder wall and thorax

Pheochromocytoma is occasionally seen posterior to the renal vein in

transverse scans Rarely pheochromocytoma is diagnosed in the

setting of multiple endocrine neoplasia (MEN) From 2 to 5 of

pheochromocytomas are malignant Owing to the risk of inciting a

hypertensive crisis fine-needle aspiration biopsy causes discrepant

discussions about FNB

Nonhomogeneous tumour with a hyperechoic center (positive endocrine test increased catecholamine secretion) ndash Pheochromocytoma

Large functionally active pheochromocytoma (7 cm in diameter) The scan shows that most of tumour is hypoechoic with some hyperechoic regions

Lymphoma The adrenal region is a rare extranodal site of occurrence for lymphoma

Foci of lymphomatous infiltration have smooth borders and are

hypoechoic Differentiation is required from lymphomas in the renal or

splenic hilum If invasion by lymphoma is suspected other nodal

stations should be scanned and commonly infiltrated organs (spleen

liver) should be closely scrutinized

Perisplenic lymphoma in the left adrenal region of a patient with B-cell lymphoma

Colour Doppler shows hypervascularisation of the lymphatic tissue

Adrenal Carcinoma Adrenal carcinoma is usually inhomogeneous hypoechoic or echo complex with irregular margins It frequently infiltrates its surroundings and metastases can be demonstrated in the adrenal region and in other organs (eg the liver) The adrenal carcinoma is a very rare (1 17 million inhabitants) highly malignant tumour with a poor prognosis Adrenal carcinoma is indistinguishable sonographically from a metastasis although the visualization of additional tumours can advance the differential diagnosis Most adrenal carcinomas are hormone-producing Sometimes one can get evidence from detection of other tumour sign The tumour is usually detected only after it has reached considerable size (often gt8 cm) Intratumoral hemorrhage necrotic foci and calcifications may occur adding to the variegated appearance

Adrenal carcinoma may be hypoechoic or may have a complex echo structure Usually it

was relatively large when diagnosed (in this case 8 cm times 9 cm) and had irregular margins

Right adrenal adenocarcinoma A Sonogram showing a complex mass with cystic changes in the right adrenal gland (arrows) B Computed tomogram showing the mass (arrows)

Incidentaloma An incidentaloma is an adrenal tumour that is detected incidentally in an asymptomatic patient Incidentalomas are found in 1 of CT examinations They are much less common in ultrasound examinations because of the difficulty in defining small lesions (lt 2 cm) The predominantly hypoechoic tumours account for the great majority of incidentalomas shows the algorithm used in the investigation of incidentalomas Approximately 10 to 15 of these tumours are hormonally active In some cases ultrasound-guided fine-needle aspiration can also aid in the evaluation of incidentalomas but only ca 1 to 2 of these tumours are malignant

Abdominal ultrasound examination incidentally found most hypoechoic lesions

smaller 2 cm without clinical symptoms ndash which is typical for incidentalomas

Histoplasmosis is a geographically restricted form of

fungal infection Adrenal involvement is seen in disseminated disease but sometimes it may be the only site of demonstrable disease Early diagnosis and treatment may save the patient from catastrophic adrenal insufficiency We present two patients showing bilateral adrenomegaly on ultrasonography and contrast-enhanced CT and was diagnosed to have histoplasmosis on fine-needle aspiration cytology

Histoplasmosis is an infective condition caused by a

dimorphic saprophytic fungus Histoplasma capsulatum and is acquired by inhalation of its spores Soil rich in bird and bat dropping is its natural habitat and it exists as a mycelium in the atmosphere

Both adrenal gland were enlarged and hypoechoic at US study

US show bilateral hypoechoic lesions and CT showed peripherally enhancing hypodense bilateral adrenals with peripheral rim and septate enhancement

ULTRASOUND OF THE ADULT KIDNEY ndash Normal

Coronal scan plane for the Right Kidney Longitudinal Normal Kidney

Scan plane transverse kidney Transverse normal image

Common anatomical variantsAtrophic small kidneyHorseshoe kidneyEctopic kidneyDuplex kidneyCross fused ectopiaUnilateral renal agenesis

COMMON PATHOLOGYCalculusRenal cyst Cortical and Para-pelvicAngiomyolipmaRenal infectionRenal cell carcinomaTransitional cell carcinomaMedullary sponge kidneyPolycystic kidney disease

Horseshoe kidney A transverse and longitudinal view across the midline showing the isthmus across the aorta

Cross fused ectopic kidney The left kidney is fused to the lower pole of the right kidney

A baggy extra-renal pelvis

Pelvic ectopic kidney

UltrasonographyOn sonograms stones are demonstrated as bright echogenic foci with posterior acoustic shadowing Stones are visualized fairly well with US in the kidneys and the distal ureter at or near the UVJ especially if dilatation is present US is good for the visualization of complications such as hydronephrosis (or other signs of obstruction) however some patients with acute obstruction have little or no dilationIn particular US is helpful in evaluating those with renal insufficiency or contraindications for the use of contrast media however US is often skipped in favor of nonenhanced CTIn addition US is good for characterizing lucent filling defects that are visualized as stones on IVU However US does not provide direct physiologic information regarding the degree of obstruction Doppler imaging may demonstrate a high resistive index in acute obstruction but this may not occur immediately or after forniceal rupture Absence of the ureteral jet as visualized with color Doppler on the symptomatic side is presumptive evidence for a high-grade obstruction in a well-hydrated patient

Degree of confidenceUS is very insensitive for stones especially stones smaller than 2 mm stones at the UPJ or stones in the mid ureter Fowler et al suggest that US has a sensitivity as low as 24 compared with nonenhanced CT Furthermore estimations of stone size may not be accurate Compared with nonenhanced CT US is more dependent on the operators ability and more time consuming

False positivesnegativesUS is fairly specific when stones are seen with a specificity as high as 90 With US matrix or indinavir stones may have soft tissue echogenicity without shadowing False-positive findings may result from renal vascular calcifications False-positive diagnoses of hydronephrosis also result from dilated vascular structures in the renal hilum Doppler imaging is helpful in distinguishing dilated vascular structures from hydronephrosis

Renal sonogram demonstrates an echogenic shadowing calculus in the renal collecting system with hydronephrosis

US images for renal stones

US images of staghorn stones

US images for ureteric stones

US images for nephrocalcinosis

Renal cystA renal cyst is a fluid collection in the kidney There are several types based on the Bosniak classification The majority are benign simple cysts that can be monitored and not intervened upon However some are cancerous or are suspicious for cancer and are commonly removed in a surgical procedure called nephrectomyNumerous renal cysts are seen in the cystic kidney diseases which include polycystic kidney diseaseand medullary sponge kidney

The Bosniak classification categorizes renal cysts into five groupsCategory I

Benign simple cyst with thin wall without septa calcifications or solid

components

It does not enhance with contrast and has a density equal to that of water

Category IIBenign cyst with a few thin septa which may contain fine calcifications or a

small

segment of mildly thickened calcification This includes homogenous

high-attenuation lesions less than 3 cm with sharp margins(Rich Kosak) but

without enhancement

Category IIFWell marginated cysts with a number of thin septa with or without mild

enhancement or thickening of septa Calcifications may be present these

may be thick and nodular There are no enhancing soft tissue components

This also includes nonenhancing high-attenuation lesions that are completely

contained within the kidney and are 3 cm or larger

Category IIIIndeterminate cystic masses with thickened irregular septa with enhancement

Category IVMalignant cystic masses with all the characteristics of category III lesions

but also with enhancing soft tissue components independent of but adjacent

to the septa

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 11)

Classic findings of a simple cyst(Bosniak category 111)

Classic findings of a simple cyst(Bosniak category 1V)

Para-pelvic cyst USamp CT images

US of polycystic kidney disease

Renal infection

US of acute pyelonephritis

Acute bacterial pyelonephritis (a) US scan shows a wedge-shaped hyperechoic focus (arrowhead) in the upper pole of the right kidney related to acute bacterial pyelonephritis (b) Color flow US image demonstrates diminished flow through the involved area

US and color Doppler images of right kidney shows focal hyperechoic nephritis with decreased perfusion at the Doppler US

US and color Doppler images of kidney shows two multifocal nephritis with decreased perfusion at the Doppler US

Masslike appearance of acute bacterial pyelonephritis US and CT images

Emphysematous pyelonephritis (a) US image shows nondependent echoes within the left kidney that demonstrate a ring-down artifact (b) Corresponding CT scan helps confirm that this pattern is caused by intraparenchymal air

Xanthogranulomatous pyelonephritis (a) Contrast-enhanced CT scan demonstrates bilateral staghorn calculi with distention of the right collecting system secondary to inflammatory debris (b) US scan also shows the dilated

collecting system (arrowheads) and a shadowing calculus (arrow)

Early and mature abscess cavities (a) US scan demonstrates a geographic hypoechoic focus from an abscess in the upper pole of the right kidney (b) On a US scan of a more mature abscess the cavity is better defined with a visible pseudocapsule and through transmission that is evidenced by increased echogenicity deep to the upper pole lesion

Pyohydronephrosis

Pyohydronephrosis

Renal hydatidosis is an insidious disease and patients

often present with nonspecific clinical signs or symptoms Presenting complaints are dull flank pain hematuria palpable flank mass hypertension and renal colic

Disseminated abdominal retroperitoneal and pelvic hydatid disease (a) The right kidney is pushed to the midline and the left kidney is hydronephrotic and shrunken by retroperitoneal hydatid cysts (b) Ultrasound of the abdomen showing cystic lesions in the retroperitoneum in the position of the kidneys

Hydatid disease of the kidney US and CT images

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 30: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Nonhomogeneous tumour with a hyperechoic center (positive endocrine test increased catecholamine secretion) ndash Pheochromocytoma

Large functionally active pheochromocytoma (7 cm in diameter) The scan shows that most of tumour is hypoechoic with some hyperechoic regions

Lymphoma The adrenal region is a rare extranodal site of occurrence for lymphoma

Foci of lymphomatous infiltration have smooth borders and are

hypoechoic Differentiation is required from lymphomas in the renal or

splenic hilum If invasion by lymphoma is suspected other nodal

stations should be scanned and commonly infiltrated organs (spleen

liver) should be closely scrutinized

Perisplenic lymphoma in the left adrenal region of a patient with B-cell lymphoma

Colour Doppler shows hypervascularisation of the lymphatic tissue

Adrenal Carcinoma Adrenal carcinoma is usually inhomogeneous hypoechoic or echo complex with irregular margins It frequently infiltrates its surroundings and metastases can be demonstrated in the adrenal region and in other organs (eg the liver) The adrenal carcinoma is a very rare (1 17 million inhabitants) highly malignant tumour with a poor prognosis Adrenal carcinoma is indistinguishable sonographically from a metastasis although the visualization of additional tumours can advance the differential diagnosis Most adrenal carcinomas are hormone-producing Sometimes one can get evidence from detection of other tumour sign The tumour is usually detected only after it has reached considerable size (often gt8 cm) Intratumoral hemorrhage necrotic foci and calcifications may occur adding to the variegated appearance

Adrenal carcinoma may be hypoechoic or may have a complex echo structure Usually it

was relatively large when diagnosed (in this case 8 cm times 9 cm) and had irregular margins

Right adrenal adenocarcinoma A Sonogram showing a complex mass with cystic changes in the right adrenal gland (arrows) B Computed tomogram showing the mass (arrows)

Incidentaloma An incidentaloma is an adrenal tumour that is detected incidentally in an asymptomatic patient Incidentalomas are found in 1 of CT examinations They are much less common in ultrasound examinations because of the difficulty in defining small lesions (lt 2 cm) The predominantly hypoechoic tumours account for the great majority of incidentalomas shows the algorithm used in the investigation of incidentalomas Approximately 10 to 15 of these tumours are hormonally active In some cases ultrasound-guided fine-needle aspiration can also aid in the evaluation of incidentalomas but only ca 1 to 2 of these tumours are malignant

Abdominal ultrasound examination incidentally found most hypoechoic lesions

smaller 2 cm without clinical symptoms ndash which is typical for incidentalomas

Histoplasmosis is a geographically restricted form of

fungal infection Adrenal involvement is seen in disseminated disease but sometimes it may be the only site of demonstrable disease Early diagnosis and treatment may save the patient from catastrophic adrenal insufficiency We present two patients showing bilateral adrenomegaly on ultrasonography and contrast-enhanced CT and was diagnosed to have histoplasmosis on fine-needle aspiration cytology

Histoplasmosis is an infective condition caused by a

dimorphic saprophytic fungus Histoplasma capsulatum and is acquired by inhalation of its spores Soil rich in bird and bat dropping is its natural habitat and it exists as a mycelium in the atmosphere

Both adrenal gland were enlarged and hypoechoic at US study

US show bilateral hypoechoic lesions and CT showed peripherally enhancing hypodense bilateral adrenals with peripheral rim and septate enhancement

ULTRASOUND OF THE ADULT KIDNEY ndash Normal

Coronal scan plane for the Right Kidney Longitudinal Normal Kidney

Scan plane transverse kidney Transverse normal image

Common anatomical variantsAtrophic small kidneyHorseshoe kidneyEctopic kidneyDuplex kidneyCross fused ectopiaUnilateral renal agenesis

COMMON PATHOLOGYCalculusRenal cyst Cortical and Para-pelvicAngiomyolipmaRenal infectionRenal cell carcinomaTransitional cell carcinomaMedullary sponge kidneyPolycystic kidney disease

Horseshoe kidney A transverse and longitudinal view across the midline showing the isthmus across the aorta

Cross fused ectopic kidney The left kidney is fused to the lower pole of the right kidney

A baggy extra-renal pelvis

Pelvic ectopic kidney

UltrasonographyOn sonograms stones are demonstrated as bright echogenic foci with posterior acoustic shadowing Stones are visualized fairly well with US in the kidneys and the distal ureter at or near the UVJ especially if dilatation is present US is good for the visualization of complications such as hydronephrosis (or other signs of obstruction) however some patients with acute obstruction have little or no dilationIn particular US is helpful in evaluating those with renal insufficiency or contraindications for the use of contrast media however US is often skipped in favor of nonenhanced CTIn addition US is good for characterizing lucent filling defects that are visualized as stones on IVU However US does not provide direct physiologic information regarding the degree of obstruction Doppler imaging may demonstrate a high resistive index in acute obstruction but this may not occur immediately or after forniceal rupture Absence of the ureteral jet as visualized with color Doppler on the symptomatic side is presumptive evidence for a high-grade obstruction in a well-hydrated patient

Degree of confidenceUS is very insensitive for stones especially stones smaller than 2 mm stones at the UPJ or stones in the mid ureter Fowler et al suggest that US has a sensitivity as low as 24 compared with nonenhanced CT Furthermore estimations of stone size may not be accurate Compared with nonenhanced CT US is more dependent on the operators ability and more time consuming

False positivesnegativesUS is fairly specific when stones are seen with a specificity as high as 90 With US matrix or indinavir stones may have soft tissue echogenicity without shadowing False-positive findings may result from renal vascular calcifications False-positive diagnoses of hydronephrosis also result from dilated vascular structures in the renal hilum Doppler imaging is helpful in distinguishing dilated vascular structures from hydronephrosis

Renal sonogram demonstrates an echogenic shadowing calculus in the renal collecting system with hydronephrosis

US images for renal stones

US images of staghorn stones

US images for ureteric stones

US images for nephrocalcinosis

Renal cystA renal cyst is a fluid collection in the kidney There are several types based on the Bosniak classification The majority are benign simple cysts that can be monitored and not intervened upon However some are cancerous or are suspicious for cancer and are commonly removed in a surgical procedure called nephrectomyNumerous renal cysts are seen in the cystic kidney diseases which include polycystic kidney diseaseand medullary sponge kidney

The Bosniak classification categorizes renal cysts into five groupsCategory I

Benign simple cyst with thin wall without septa calcifications or solid

components

It does not enhance with contrast and has a density equal to that of water

Category IIBenign cyst with a few thin septa which may contain fine calcifications or a

small

segment of mildly thickened calcification This includes homogenous

high-attenuation lesions less than 3 cm with sharp margins(Rich Kosak) but

without enhancement

Category IIFWell marginated cysts with a number of thin septa with or without mild

enhancement or thickening of septa Calcifications may be present these

may be thick and nodular There are no enhancing soft tissue components

This also includes nonenhancing high-attenuation lesions that are completely

contained within the kidney and are 3 cm or larger

Category IIIIndeterminate cystic masses with thickened irregular septa with enhancement

Category IVMalignant cystic masses with all the characteristics of category III lesions

but also with enhancing soft tissue components independent of but adjacent

to the septa

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 11)

Classic findings of a simple cyst(Bosniak category 111)

Classic findings of a simple cyst(Bosniak category 1V)

Para-pelvic cyst USamp CT images

US of polycystic kidney disease

Renal infection

US of acute pyelonephritis

Acute bacterial pyelonephritis (a) US scan shows a wedge-shaped hyperechoic focus (arrowhead) in the upper pole of the right kidney related to acute bacterial pyelonephritis (b) Color flow US image demonstrates diminished flow through the involved area

US and color Doppler images of right kidney shows focal hyperechoic nephritis with decreased perfusion at the Doppler US

US and color Doppler images of kidney shows two multifocal nephritis with decreased perfusion at the Doppler US

Masslike appearance of acute bacterial pyelonephritis US and CT images

Emphysematous pyelonephritis (a) US image shows nondependent echoes within the left kidney that demonstrate a ring-down artifact (b) Corresponding CT scan helps confirm that this pattern is caused by intraparenchymal air

Xanthogranulomatous pyelonephritis (a) Contrast-enhanced CT scan demonstrates bilateral staghorn calculi with distention of the right collecting system secondary to inflammatory debris (b) US scan also shows the dilated

collecting system (arrowheads) and a shadowing calculus (arrow)

Early and mature abscess cavities (a) US scan demonstrates a geographic hypoechoic focus from an abscess in the upper pole of the right kidney (b) On a US scan of a more mature abscess the cavity is better defined with a visible pseudocapsule and through transmission that is evidenced by increased echogenicity deep to the upper pole lesion

Pyohydronephrosis

Pyohydronephrosis

Renal hydatidosis is an insidious disease and patients

often present with nonspecific clinical signs or symptoms Presenting complaints are dull flank pain hematuria palpable flank mass hypertension and renal colic

Disseminated abdominal retroperitoneal and pelvic hydatid disease (a) The right kidney is pushed to the midline and the left kidney is hydronephrotic and shrunken by retroperitoneal hydatid cysts (b) Ultrasound of the abdomen showing cystic lesions in the retroperitoneum in the position of the kidneys

Hydatid disease of the kidney US and CT images

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 31: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Large functionally active pheochromocytoma (7 cm in diameter) The scan shows that most of tumour is hypoechoic with some hyperechoic regions

Lymphoma The adrenal region is a rare extranodal site of occurrence for lymphoma

Foci of lymphomatous infiltration have smooth borders and are

hypoechoic Differentiation is required from lymphomas in the renal or

splenic hilum If invasion by lymphoma is suspected other nodal

stations should be scanned and commonly infiltrated organs (spleen

liver) should be closely scrutinized

Perisplenic lymphoma in the left adrenal region of a patient with B-cell lymphoma

Colour Doppler shows hypervascularisation of the lymphatic tissue

Adrenal Carcinoma Adrenal carcinoma is usually inhomogeneous hypoechoic or echo complex with irregular margins It frequently infiltrates its surroundings and metastases can be demonstrated in the adrenal region and in other organs (eg the liver) The adrenal carcinoma is a very rare (1 17 million inhabitants) highly malignant tumour with a poor prognosis Adrenal carcinoma is indistinguishable sonographically from a metastasis although the visualization of additional tumours can advance the differential diagnosis Most adrenal carcinomas are hormone-producing Sometimes one can get evidence from detection of other tumour sign The tumour is usually detected only after it has reached considerable size (often gt8 cm) Intratumoral hemorrhage necrotic foci and calcifications may occur adding to the variegated appearance

Adrenal carcinoma may be hypoechoic or may have a complex echo structure Usually it

was relatively large when diagnosed (in this case 8 cm times 9 cm) and had irregular margins

Right adrenal adenocarcinoma A Sonogram showing a complex mass with cystic changes in the right adrenal gland (arrows) B Computed tomogram showing the mass (arrows)

Incidentaloma An incidentaloma is an adrenal tumour that is detected incidentally in an asymptomatic patient Incidentalomas are found in 1 of CT examinations They are much less common in ultrasound examinations because of the difficulty in defining small lesions (lt 2 cm) The predominantly hypoechoic tumours account for the great majority of incidentalomas shows the algorithm used in the investigation of incidentalomas Approximately 10 to 15 of these tumours are hormonally active In some cases ultrasound-guided fine-needle aspiration can also aid in the evaluation of incidentalomas but only ca 1 to 2 of these tumours are malignant

Abdominal ultrasound examination incidentally found most hypoechoic lesions

smaller 2 cm without clinical symptoms ndash which is typical for incidentalomas

Histoplasmosis is a geographically restricted form of

fungal infection Adrenal involvement is seen in disseminated disease but sometimes it may be the only site of demonstrable disease Early diagnosis and treatment may save the patient from catastrophic adrenal insufficiency We present two patients showing bilateral adrenomegaly on ultrasonography and contrast-enhanced CT and was diagnosed to have histoplasmosis on fine-needle aspiration cytology

Histoplasmosis is an infective condition caused by a

dimorphic saprophytic fungus Histoplasma capsulatum and is acquired by inhalation of its spores Soil rich in bird and bat dropping is its natural habitat and it exists as a mycelium in the atmosphere

Both adrenal gland were enlarged and hypoechoic at US study

US show bilateral hypoechoic lesions and CT showed peripherally enhancing hypodense bilateral adrenals with peripheral rim and septate enhancement

ULTRASOUND OF THE ADULT KIDNEY ndash Normal

Coronal scan plane for the Right Kidney Longitudinal Normal Kidney

Scan plane transverse kidney Transverse normal image

Common anatomical variantsAtrophic small kidneyHorseshoe kidneyEctopic kidneyDuplex kidneyCross fused ectopiaUnilateral renal agenesis

COMMON PATHOLOGYCalculusRenal cyst Cortical and Para-pelvicAngiomyolipmaRenal infectionRenal cell carcinomaTransitional cell carcinomaMedullary sponge kidneyPolycystic kidney disease

Horseshoe kidney A transverse and longitudinal view across the midline showing the isthmus across the aorta

Cross fused ectopic kidney The left kidney is fused to the lower pole of the right kidney

A baggy extra-renal pelvis

Pelvic ectopic kidney

UltrasonographyOn sonograms stones are demonstrated as bright echogenic foci with posterior acoustic shadowing Stones are visualized fairly well with US in the kidneys and the distal ureter at or near the UVJ especially if dilatation is present US is good for the visualization of complications such as hydronephrosis (or other signs of obstruction) however some patients with acute obstruction have little or no dilationIn particular US is helpful in evaluating those with renal insufficiency or contraindications for the use of contrast media however US is often skipped in favor of nonenhanced CTIn addition US is good for characterizing lucent filling defects that are visualized as stones on IVU However US does not provide direct physiologic information regarding the degree of obstruction Doppler imaging may demonstrate a high resistive index in acute obstruction but this may not occur immediately or after forniceal rupture Absence of the ureteral jet as visualized with color Doppler on the symptomatic side is presumptive evidence for a high-grade obstruction in a well-hydrated patient

Degree of confidenceUS is very insensitive for stones especially stones smaller than 2 mm stones at the UPJ or stones in the mid ureter Fowler et al suggest that US has a sensitivity as low as 24 compared with nonenhanced CT Furthermore estimations of stone size may not be accurate Compared with nonenhanced CT US is more dependent on the operators ability and more time consuming

False positivesnegativesUS is fairly specific when stones are seen with a specificity as high as 90 With US matrix or indinavir stones may have soft tissue echogenicity without shadowing False-positive findings may result from renal vascular calcifications False-positive diagnoses of hydronephrosis also result from dilated vascular structures in the renal hilum Doppler imaging is helpful in distinguishing dilated vascular structures from hydronephrosis

Renal sonogram demonstrates an echogenic shadowing calculus in the renal collecting system with hydronephrosis

US images for renal stones

US images of staghorn stones

US images for ureteric stones

US images for nephrocalcinosis

Renal cystA renal cyst is a fluid collection in the kidney There are several types based on the Bosniak classification The majority are benign simple cysts that can be monitored and not intervened upon However some are cancerous or are suspicious for cancer and are commonly removed in a surgical procedure called nephrectomyNumerous renal cysts are seen in the cystic kidney diseases which include polycystic kidney diseaseand medullary sponge kidney

The Bosniak classification categorizes renal cysts into five groupsCategory I

Benign simple cyst with thin wall without septa calcifications or solid

components

It does not enhance with contrast and has a density equal to that of water

Category IIBenign cyst with a few thin septa which may contain fine calcifications or a

small

segment of mildly thickened calcification This includes homogenous

high-attenuation lesions less than 3 cm with sharp margins(Rich Kosak) but

without enhancement

Category IIFWell marginated cysts with a number of thin septa with or without mild

enhancement or thickening of septa Calcifications may be present these

may be thick and nodular There are no enhancing soft tissue components

This also includes nonenhancing high-attenuation lesions that are completely

contained within the kidney and are 3 cm or larger

Category IIIIndeterminate cystic masses with thickened irregular septa with enhancement

Category IVMalignant cystic masses with all the characteristics of category III lesions

but also with enhancing soft tissue components independent of but adjacent

to the septa

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 11)

Classic findings of a simple cyst(Bosniak category 111)

Classic findings of a simple cyst(Bosniak category 1V)

Para-pelvic cyst USamp CT images

US of polycystic kidney disease

Renal infection

US of acute pyelonephritis

Acute bacterial pyelonephritis (a) US scan shows a wedge-shaped hyperechoic focus (arrowhead) in the upper pole of the right kidney related to acute bacterial pyelonephritis (b) Color flow US image demonstrates diminished flow through the involved area

US and color Doppler images of right kidney shows focal hyperechoic nephritis with decreased perfusion at the Doppler US

US and color Doppler images of kidney shows two multifocal nephritis with decreased perfusion at the Doppler US

Masslike appearance of acute bacterial pyelonephritis US and CT images

Emphysematous pyelonephritis (a) US image shows nondependent echoes within the left kidney that demonstrate a ring-down artifact (b) Corresponding CT scan helps confirm that this pattern is caused by intraparenchymal air

Xanthogranulomatous pyelonephritis (a) Contrast-enhanced CT scan demonstrates bilateral staghorn calculi with distention of the right collecting system secondary to inflammatory debris (b) US scan also shows the dilated

collecting system (arrowheads) and a shadowing calculus (arrow)

Early and mature abscess cavities (a) US scan demonstrates a geographic hypoechoic focus from an abscess in the upper pole of the right kidney (b) On a US scan of a more mature abscess the cavity is better defined with a visible pseudocapsule and through transmission that is evidenced by increased echogenicity deep to the upper pole lesion

Pyohydronephrosis

Pyohydronephrosis

Renal hydatidosis is an insidious disease and patients

often present with nonspecific clinical signs or symptoms Presenting complaints are dull flank pain hematuria palpable flank mass hypertension and renal colic

Disseminated abdominal retroperitoneal and pelvic hydatid disease (a) The right kidney is pushed to the midline and the left kidney is hydronephrotic and shrunken by retroperitoneal hydatid cysts (b) Ultrasound of the abdomen showing cystic lesions in the retroperitoneum in the position of the kidneys

Hydatid disease of the kidney US and CT images

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 32: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Lymphoma The adrenal region is a rare extranodal site of occurrence for lymphoma

Foci of lymphomatous infiltration have smooth borders and are

hypoechoic Differentiation is required from lymphomas in the renal or

splenic hilum If invasion by lymphoma is suspected other nodal

stations should be scanned and commonly infiltrated organs (spleen

liver) should be closely scrutinized

Perisplenic lymphoma in the left adrenal region of a patient with B-cell lymphoma

Colour Doppler shows hypervascularisation of the lymphatic tissue

Adrenal Carcinoma Adrenal carcinoma is usually inhomogeneous hypoechoic or echo complex with irregular margins It frequently infiltrates its surroundings and metastases can be demonstrated in the adrenal region and in other organs (eg the liver) The adrenal carcinoma is a very rare (1 17 million inhabitants) highly malignant tumour with a poor prognosis Adrenal carcinoma is indistinguishable sonographically from a metastasis although the visualization of additional tumours can advance the differential diagnosis Most adrenal carcinomas are hormone-producing Sometimes one can get evidence from detection of other tumour sign The tumour is usually detected only after it has reached considerable size (often gt8 cm) Intratumoral hemorrhage necrotic foci and calcifications may occur adding to the variegated appearance

Adrenal carcinoma may be hypoechoic or may have a complex echo structure Usually it

was relatively large when diagnosed (in this case 8 cm times 9 cm) and had irregular margins

Right adrenal adenocarcinoma A Sonogram showing a complex mass with cystic changes in the right adrenal gland (arrows) B Computed tomogram showing the mass (arrows)

Incidentaloma An incidentaloma is an adrenal tumour that is detected incidentally in an asymptomatic patient Incidentalomas are found in 1 of CT examinations They are much less common in ultrasound examinations because of the difficulty in defining small lesions (lt 2 cm) The predominantly hypoechoic tumours account for the great majority of incidentalomas shows the algorithm used in the investigation of incidentalomas Approximately 10 to 15 of these tumours are hormonally active In some cases ultrasound-guided fine-needle aspiration can also aid in the evaluation of incidentalomas but only ca 1 to 2 of these tumours are malignant

Abdominal ultrasound examination incidentally found most hypoechoic lesions

smaller 2 cm without clinical symptoms ndash which is typical for incidentalomas

Histoplasmosis is a geographically restricted form of

fungal infection Adrenal involvement is seen in disseminated disease but sometimes it may be the only site of demonstrable disease Early diagnosis and treatment may save the patient from catastrophic adrenal insufficiency We present two patients showing bilateral adrenomegaly on ultrasonography and contrast-enhanced CT and was diagnosed to have histoplasmosis on fine-needle aspiration cytology

Histoplasmosis is an infective condition caused by a

dimorphic saprophytic fungus Histoplasma capsulatum and is acquired by inhalation of its spores Soil rich in bird and bat dropping is its natural habitat and it exists as a mycelium in the atmosphere

Both adrenal gland were enlarged and hypoechoic at US study

US show bilateral hypoechoic lesions and CT showed peripherally enhancing hypodense bilateral adrenals with peripheral rim and septate enhancement

ULTRASOUND OF THE ADULT KIDNEY ndash Normal

Coronal scan plane for the Right Kidney Longitudinal Normal Kidney

Scan plane transverse kidney Transverse normal image

Common anatomical variantsAtrophic small kidneyHorseshoe kidneyEctopic kidneyDuplex kidneyCross fused ectopiaUnilateral renal agenesis

COMMON PATHOLOGYCalculusRenal cyst Cortical and Para-pelvicAngiomyolipmaRenal infectionRenal cell carcinomaTransitional cell carcinomaMedullary sponge kidneyPolycystic kidney disease

Horseshoe kidney A transverse and longitudinal view across the midline showing the isthmus across the aorta

Cross fused ectopic kidney The left kidney is fused to the lower pole of the right kidney

A baggy extra-renal pelvis

Pelvic ectopic kidney

UltrasonographyOn sonograms stones are demonstrated as bright echogenic foci with posterior acoustic shadowing Stones are visualized fairly well with US in the kidneys and the distal ureter at or near the UVJ especially if dilatation is present US is good for the visualization of complications such as hydronephrosis (or other signs of obstruction) however some patients with acute obstruction have little or no dilationIn particular US is helpful in evaluating those with renal insufficiency or contraindications for the use of contrast media however US is often skipped in favor of nonenhanced CTIn addition US is good for characterizing lucent filling defects that are visualized as stones on IVU However US does not provide direct physiologic information regarding the degree of obstruction Doppler imaging may demonstrate a high resistive index in acute obstruction but this may not occur immediately or after forniceal rupture Absence of the ureteral jet as visualized with color Doppler on the symptomatic side is presumptive evidence for a high-grade obstruction in a well-hydrated patient

Degree of confidenceUS is very insensitive for stones especially stones smaller than 2 mm stones at the UPJ or stones in the mid ureter Fowler et al suggest that US has a sensitivity as low as 24 compared with nonenhanced CT Furthermore estimations of stone size may not be accurate Compared with nonenhanced CT US is more dependent on the operators ability and more time consuming

False positivesnegativesUS is fairly specific when stones are seen with a specificity as high as 90 With US matrix or indinavir stones may have soft tissue echogenicity without shadowing False-positive findings may result from renal vascular calcifications False-positive diagnoses of hydronephrosis also result from dilated vascular structures in the renal hilum Doppler imaging is helpful in distinguishing dilated vascular structures from hydronephrosis

Renal sonogram demonstrates an echogenic shadowing calculus in the renal collecting system with hydronephrosis

US images for renal stones

US images of staghorn stones

US images for ureteric stones

US images for nephrocalcinosis

Renal cystA renal cyst is a fluid collection in the kidney There are several types based on the Bosniak classification The majority are benign simple cysts that can be monitored and not intervened upon However some are cancerous or are suspicious for cancer and are commonly removed in a surgical procedure called nephrectomyNumerous renal cysts are seen in the cystic kidney diseases which include polycystic kidney diseaseand medullary sponge kidney

The Bosniak classification categorizes renal cysts into five groupsCategory I

Benign simple cyst with thin wall without septa calcifications or solid

components

It does not enhance with contrast and has a density equal to that of water

Category IIBenign cyst with a few thin septa which may contain fine calcifications or a

small

segment of mildly thickened calcification This includes homogenous

high-attenuation lesions less than 3 cm with sharp margins(Rich Kosak) but

without enhancement

Category IIFWell marginated cysts with a number of thin septa with or without mild

enhancement or thickening of septa Calcifications may be present these

may be thick and nodular There are no enhancing soft tissue components

This also includes nonenhancing high-attenuation lesions that are completely

contained within the kidney and are 3 cm or larger

Category IIIIndeterminate cystic masses with thickened irregular septa with enhancement

Category IVMalignant cystic masses with all the characteristics of category III lesions

but also with enhancing soft tissue components independent of but adjacent

to the septa

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 11)

Classic findings of a simple cyst(Bosniak category 111)

Classic findings of a simple cyst(Bosniak category 1V)

Para-pelvic cyst USamp CT images

US of polycystic kidney disease

Renal infection

US of acute pyelonephritis

Acute bacterial pyelonephritis (a) US scan shows a wedge-shaped hyperechoic focus (arrowhead) in the upper pole of the right kidney related to acute bacterial pyelonephritis (b) Color flow US image demonstrates diminished flow through the involved area

US and color Doppler images of right kidney shows focal hyperechoic nephritis with decreased perfusion at the Doppler US

US and color Doppler images of kidney shows two multifocal nephritis with decreased perfusion at the Doppler US

Masslike appearance of acute bacterial pyelonephritis US and CT images

Emphysematous pyelonephritis (a) US image shows nondependent echoes within the left kidney that demonstrate a ring-down artifact (b) Corresponding CT scan helps confirm that this pattern is caused by intraparenchymal air

Xanthogranulomatous pyelonephritis (a) Contrast-enhanced CT scan demonstrates bilateral staghorn calculi with distention of the right collecting system secondary to inflammatory debris (b) US scan also shows the dilated

collecting system (arrowheads) and a shadowing calculus (arrow)

Early and mature abscess cavities (a) US scan demonstrates a geographic hypoechoic focus from an abscess in the upper pole of the right kidney (b) On a US scan of a more mature abscess the cavity is better defined with a visible pseudocapsule and through transmission that is evidenced by increased echogenicity deep to the upper pole lesion

Pyohydronephrosis

Pyohydronephrosis

Renal hydatidosis is an insidious disease and patients

often present with nonspecific clinical signs or symptoms Presenting complaints are dull flank pain hematuria palpable flank mass hypertension and renal colic

Disseminated abdominal retroperitoneal and pelvic hydatid disease (a) The right kidney is pushed to the midline and the left kidney is hydronephrotic and shrunken by retroperitoneal hydatid cysts (b) Ultrasound of the abdomen showing cystic lesions in the retroperitoneum in the position of the kidneys

Hydatid disease of the kidney US and CT images

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 33: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Adrenal Carcinoma Adrenal carcinoma is usually inhomogeneous hypoechoic or echo complex with irregular margins It frequently infiltrates its surroundings and metastases can be demonstrated in the adrenal region and in other organs (eg the liver) The adrenal carcinoma is a very rare (1 17 million inhabitants) highly malignant tumour with a poor prognosis Adrenal carcinoma is indistinguishable sonographically from a metastasis although the visualization of additional tumours can advance the differential diagnosis Most adrenal carcinomas are hormone-producing Sometimes one can get evidence from detection of other tumour sign The tumour is usually detected only after it has reached considerable size (often gt8 cm) Intratumoral hemorrhage necrotic foci and calcifications may occur adding to the variegated appearance

Adrenal carcinoma may be hypoechoic or may have a complex echo structure Usually it

was relatively large when diagnosed (in this case 8 cm times 9 cm) and had irregular margins

Right adrenal adenocarcinoma A Sonogram showing a complex mass with cystic changes in the right adrenal gland (arrows) B Computed tomogram showing the mass (arrows)

Incidentaloma An incidentaloma is an adrenal tumour that is detected incidentally in an asymptomatic patient Incidentalomas are found in 1 of CT examinations They are much less common in ultrasound examinations because of the difficulty in defining small lesions (lt 2 cm) The predominantly hypoechoic tumours account for the great majority of incidentalomas shows the algorithm used in the investigation of incidentalomas Approximately 10 to 15 of these tumours are hormonally active In some cases ultrasound-guided fine-needle aspiration can also aid in the evaluation of incidentalomas but only ca 1 to 2 of these tumours are malignant

Abdominal ultrasound examination incidentally found most hypoechoic lesions

smaller 2 cm without clinical symptoms ndash which is typical for incidentalomas

Histoplasmosis is a geographically restricted form of

fungal infection Adrenal involvement is seen in disseminated disease but sometimes it may be the only site of demonstrable disease Early diagnosis and treatment may save the patient from catastrophic adrenal insufficiency We present two patients showing bilateral adrenomegaly on ultrasonography and contrast-enhanced CT and was diagnosed to have histoplasmosis on fine-needle aspiration cytology

Histoplasmosis is an infective condition caused by a

dimorphic saprophytic fungus Histoplasma capsulatum and is acquired by inhalation of its spores Soil rich in bird and bat dropping is its natural habitat and it exists as a mycelium in the atmosphere

Both adrenal gland were enlarged and hypoechoic at US study

US show bilateral hypoechoic lesions and CT showed peripherally enhancing hypodense bilateral adrenals with peripheral rim and septate enhancement

ULTRASOUND OF THE ADULT KIDNEY ndash Normal

Coronal scan plane for the Right Kidney Longitudinal Normal Kidney

Scan plane transverse kidney Transverse normal image

Common anatomical variantsAtrophic small kidneyHorseshoe kidneyEctopic kidneyDuplex kidneyCross fused ectopiaUnilateral renal agenesis

COMMON PATHOLOGYCalculusRenal cyst Cortical and Para-pelvicAngiomyolipmaRenal infectionRenal cell carcinomaTransitional cell carcinomaMedullary sponge kidneyPolycystic kidney disease

Horseshoe kidney A transverse and longitudinal view across the midline showing the isthmus across the aorta

Cross fused ectopic kidney The left kidney is fused to the lower pole of the right kidney

A baggy extra-renal pelvis

Pelvic ectopic kidney

UltrasonographyOn sonograms stones are demonstrated as bright echogenic foci with posterior acoustic shadowing Stones are visualized fairly well with US in the kidneys and the distal ureter at or near the UVJ especially if dilatation is present US is good for the visualization of complications such as hydronephrosis (or other signs of obstruction) however some patients with acute obstruction have little or no dilationIn particular US is helpful in evaluating those with renal insufficiency or contraindications for the use of contrast media however US is often skipped in favor of nonenhanced CTIn addition US is good for characterizing lucent filling defects that are visualized as stones on IVU However US does not provide direct physiologic information regarding the degree of obstruction Doppler imaging may demonstrate a high resistive index in acute obstruction but this may not occur immediately or after forniceal rupture Absence of the ureteral jet as visualized with color Doppler on the symptomatic side is presumptive evidence for a high-grade obstruction in a well-hydrated patient

Degree of confidenceUS is very insensitive for stones especially stones smaller than 2 mm stones at the UPJ or stones in the mid ureter Fowler et al suggest that US has a sensitivity as low as 24 compared with nonenhanced CT Furthermore estimations of stone size may not be accurate Compared with nonenhanced CT US is more dependent on the operators ability and more time consuming

False positivesnegativesUS is fairly specific when stones are seen with a specificity as high as 90 With US matrix or indinavir stones may have soft tissue echogenicity without shadowing False-positive findings may result from renal vascular calcifications False-positive diagnoses of hydronephrosis also result from dilated vascular structures in the renal hilum Doppler imaging is helpful in distinguishing dilated vascular structures from hydronephrosis

Renal sonogram demonstrates an echogenic shadowing calculus in the renal collecting system with hydronephrosis

US images for renal stones

US images of staghorn stones

US images for ureteric stones

US images for nephrocalcinosis

Renal cystA renal cyst is a fluid collection in the kidney There are several types based on the Bosniak classification The majority are benign simple cysts that can be monitored and not intervened upon However some are cancerous or are suspicious for cancer and are commonly removed in a surgical procedure called nephrectomyNumerous renal cysts are seen in the cystic kidney diseases which include polycystic kidney diseaseand medullary sponge kidney

The Bosniak classification categorizes renal cysts into five groupsCategory I

Benign simple cyst with thin wall without septa calcifications or solid

components

It does not enhance with contrast and has a density equal to that of water

Category IIBenign cyst with a few thin septa which may contain fine calcifications or a

small

segment of mildly thickened calcification This includes homogenous

high-attenuation lesions less than 3 cm with sharp margins(Rich Kosak) but

without enhancement

Category IIFWell marginated cysts with a number of thin septa with or without mild

enhancement or thickening of septa Calcifications may be present these

may be thick and nodular There are no enhancing soft tissue components

This also includes nonenhancing high-attenuation lesions that are completely

contained within the kidney and are 3 cm or larger

Category IIIIndeterminate cystic masses with thickened irregular septa with enhancement

Category IVMalignant cystic masses with all the characteristics of category III lesions

but also with enhancing soft tissue components independent of but adjacent

to the septa

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 11)

Classic findings of a simple cyst(Bosniak category 111)

Classic findings of a simple cyst(Bosniak category 1V)

Para-pelvic cyst USamp CT images

US of polycystic kidney disease

Renal infection

US of acute pyelonephritis

Acute bacterial pyelonephritis (a) US scan shows a wedge-shaped hyperechoic focus (arrowhead) in the upper pole of the right kidney related to acute bacterial pyelonephritis (b) Color flow US image demonstrates diminished flow through the involved area

US and color Doppler images of right kidney shows focal hyperechoic nephritis with decreased perfusion at the Doppler US

US and color Doppler images of kidney shows two multifocal nephritis with decreased perfusion at the Doppler US

Masslike appearance of acute bacterial pyelonephritis US and CT images

Emphysematous pyelonephritis (a) US image shows nondependent echoes within the left kidney that demonstrate a ring-down artifact (b) Corresponding CT scan helps confirm that this pattern is caused by intraparenchymal air

Xanthogranulomatous pyelonephritis (a) Contrast-enhanced CT scan demonstrates bilateral staghorn calculi with distention of the right collecting system secondary to inflammatory debris (b) US scan also shows the dilated

collecting system (arrowheads) and a shadowing calculus (arrow)

Early and mature abscess cavities (a) US scan demonstrates a geographic hypoechoic focus from an abscess in the upper pole of the right kidney (b) On a US scan of a more mature abscess the cavity is better defined with a visible pseudocapsule and through transmission that is evidenced by increased echogenicity deep to the upper pole lesion

Pyohydronephrosis

Pyohydronephrosis

Renal hydatidosis is an insidious disease and patients

often present with nonspecific clinical signs or symptoms Presenting complaints are dull flank pain hematuria palpable flank mass hypertension and renal colic

Disseminated abdominal retroperitoneal and pelvic hydatid disease (a) The right kidney is pushed to the midline and the left kidney is hydronephrotic and shrunken by retroperitoneal hydatid cysts (b) Ultrasound of the abdomen showing cystic lesions in the retroperitoneum in the position of the kidneys

Hydatid disease of the kidney US and CT images

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 34: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Adrenal carcinoma may be hypoechoic or may have a complex echo structure Usually it

was relatively large when diagnosed (in this case 8 cm times 9 cm) and had irregular margins

Right adrenal adenocarcinoma A Sonogram showing a complex mass with cystic changes in the right adrenal gland (arrows) B Computed tomogram showing the mass (arrows)

Incidentaloma An incidentaloma is an adrenal tumour that is detected incidentally in an asymptomatic patient Incidentalomas are found in 1 of CT examinations They are much less common in ultrasound examinations because of the difficulty in defining small lesions (lt 2 cm) The predominantly hypoechoic tumours account for the great majority of incidentalomas shows the algorithm used in the investigation of incidentalomas Approximately 10 to 15 of these tumours are hormonally active In some cases ultrasound-guided fine-needle aspiration can also aid in the evaluation of incidentalomas but only ca 1 to 2 of these tumours are malignant

Abdominal ultrasound examination incidentally found most hypoechoic lesions

smaller 2 cm without clinical symptoms ndash which is typical for incidentalomas

Histoplasmosis is a geographically restricted form of

fungal infection Adrenal involvement is seen in disseminated disease but sometimes it may be the only site of demonstrable disease Early diagnosis and treatment may save the patient from catastrophic adrenal insufficiency We present two patients showing bilateral adrenomegaly on ultrasonography and contrast-enhanced CT and was diagnosed to have histoplasmosis on fine-needle aspiration cytology

Histoplasmosis is an infective condition caused by a

dimorphic saprophytic fungus Histoplasma capsulatum and is acquired by inhalation of its spores Soil rich in bird and bat dropping is its natural habitat and it exists as a mycelium in the atmosphere

Both adrenal gland were enlarged and hypoechoic at US study

US show bilateral hypoechoic lesions and CT showed peripherally enhancing hypodense bilateral adrenals with peripheral rim and septate enhancement

ULTRASOUND OF THE ADULT KIDNEY ndash Normal

Coronal scan plane for the Right Kidney Longitudinal Normal Kidney

Scan plane transverse kidney Transverse normal image

Common anatomical variantsAtrophic small kidneyHorseshoe kidneyEctopic kidneyDuplex kidneyCross fused ectopiaUnilateral renal agenesis

COMMON PATHOLOGYCalculusRenal cyst Cortical and Para-pelvicAngiomyolipmaRenal infectionRenal cell carcinomaTransitional cell carcinomaMedullary sponge kidneyPolycystic kidney disease

Horseshoe kidney A transverse and longitudinal view across the midline showing the isthmus across the aorta

Cross fused ectopic kidney The left kidney is fused to the lower pole of the right kidney

A baggy extra-renal pelvis

Pelvic ectopic kidney

UltrasonographyOn sonograms stones are demonstrated as bright echogenic foci with posterior acoustic shadowing Stones are visualized fairly well with US in the kidneys and the distal ureter at or near the UVJ especially if dilatation is present US is good for the visualization of complications such as hydronephrosis (or other signs of obstruction) however some patients with acute obstruction have little or no dilationIn particular US is helpful in evaluating those with renal insufficiency or contraindications for the use of contrast media however US is often skipped in favor of nonenhanced CTIn addition US is good for characterizing lucent filling defects that are visualized as stones on IVU However US does not provide direct physiologic information regarding the degree of obstruction Doppler imaging may demonstrate a high resistive index in acute obstruction but this may not occur immediately or after forniceal rupture Absence of the ureteral jet as visualized with color Doppler on the symptomatic side is presumptive evidence for a high-grade obstruction in a well-hydrated patient

Degree of confidenceUS is very insensitive for stones especially stones smaller than 2 mm stones at the UPJ or stones in the mid ureter Fowler et al suggest that US has a sensitivity as low as 24 compared with nonenhanced CT Furthermore estimations of stone size may not be accurate Compared with nonenhanced CT US is more dependent on the operators ability and more time consuming

False positivesnegativesUS is fairly specific when stones are seen with a specificity as high as 90 With US matrix or indinavir stones may have soft tissue echogenicity without shadowing False-positive findings may result from renal vascular calcifications False-positive diagnoses of hydronephrosis also result from dilated vascular structures in the renal hilum Doppler imaging is helpful in distinguishing dilated vascular structures from hydronephrosis

Renal sonogram demonstrates an echogenic shadowing calculus in the renal collecting system with hydronephrosis

US images for renal stones

US images of staghorn stones

US images for ureteric stones

US images for nephrocalcinosis

Renal cystA renal cyst is a fluid collection in the kidney There are several types based on the Bosniak classification The majority are benign simple cysts that can be monitored and not intervened upon However some are cancerous or are suspicious for cancer and are commonly removed in a surgical procedure called nephrectomyNumerous renal cysts are seen in the cystic kidney diseases which include polycystic kidney diseaseand medullary sponge kidney

The Bosniak classification categorizes renal cysts into five groupsCategory I

Benign simple cyst with thin wall without septa calcifications or solid

components

It does not enhance with contrast and has a density equal to that of water

Category IIBenign cyst with a few thin septa which may contain fine calcifications or a

small

segment of mildly thickened calcification This includes homogenous

high-attenuation lesions less than 3 cm with sharp margins(Rich Kosak) but

without enhancement

Category IIFWell marginated cysts with a number of thin septa with or without mild

enhancement or thickening of septa Calcifications may be present these

may be thick and nodular There are no enhancing soft tissue components

This also includes nonenhancing high-attenuation lesions that are completely

contained within the kidney and are 3 cm or larger

Category IIIIndeterminate cystic masses with thickened irregular septa with enhancement

Category IVMalignant cystic masses with all the characteristics of category III lesions

but also with enhancing soft tissue components independent of but adjacent

to the septa

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 11)

Classic findings of a simple cyst(Bosniak category 111)

Classic findings of a simple cyst(Bosniak category 1V)

Para-pelvic cyst USamp CT images

US of polycystic kidney disease

Renal infection

US of acute pyelonephritis

Acute bacterial pyelonephritis (a) US scan shows a wedge-shaped hyperechoic focus (arrowhead) in the upper pole of the right kidney related to acute bacterial pyelonephritis (b) Color flow US image demonstrates diminished flow through the involved area

US and color Doppler images of right kidney shows focal hyperechoic nephritis with decreased perfusion at the Doppler US

US and color Doppler images of kidney shows two multifocal nephritis with decreased perfusion at the Doppler US

Masslike appearance of acute bacterial pyelonephritis US and CT images

Emphysematous pyelonephritis (a) US image shows nondependent echoes within the left kidney that demonstrate a ring-down artifact (b) Corresponding CT scan helps confirm that this pattern is caused by intraparenchymal air

Xanthogranulomatous pyelonephritis (a) Contrast-enhanced CT scan demonstrates bilateral staghorn calculi with distention of the right collecting system secondary to inflammatory debris (b) US scan also shows the dilated

collecting system (arrowheads) and a shadowing calculus (arrow)

Early and mature abscess cavities (a) US scan demonstrates a geographic hypoechoic focus from an abscess in the upper pole of the right kidney (b) On a US scan of a more mature abscess the cavity is better defined with a visible pseudocapsule and through transmission that is evidenced by increased echogenicity deep to the upper pole lesion

Pyohydronephrosis

Pyohydronephrosis

Renal hydatidosis is an insidious disease and patients

often present with nonspecific clinical signs or symptoms Presenting complaints are dull flank pain hematuria palpable flank mass hypertension and renal colic

Disseminated abdominal retroperitoneal and pelvic hydatid disease (a) The right kidney is pushed to the midline and the left kidney is hydronephrotic and shrunken by retroperitoneal hydatid cysts (b) Ultrasound of the abdomen showing cystic lesions in the retroperitoneum in the position of the kidneys

Hydatid disease of the kidney US and CT images

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 35: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Right adrenal adenocarcinoma A Sonogram showing a complex mass with cystic changes in the right adrenal gland (arrows) B Computed tomogram showing the mass (arrows)

Incidentaloma An incidentaloma is an adrenal tumour that is detected incidentally in an asymptomatic patient Incidentalomas are found in 1 of CT examinations They are much less common in ultrasound examinations because of the difficulty in defining small lesions (lt 2 cm) The predominantly hypoechoic tumours account for the great majority of incidentalomas shows the algorithm used in the investigation of incidentalomas Approximately 10 to 15 of these tumours are hormonally active In some cases ultrasound-guided fine-needle aspiration can also aid in the evaluation of incidentalomas but only ca 1 to 2 of these tumours are malignant

Abdominal ultrasound examination incidentally found most hypoechoic lesions

smaller 2 cm without clinical symptoms ndash which is typical for incidentalomas

Histoplasmosis is a geographically restricted form of

fungal infection Adrenal involvement is seen in disseminated disease but sometimes it may be the only site of demonstrable disease Early diagnosis and treatment may save the patient from catastrophic adrenal insufficiency We present two patients showing bilateral adrenomegaly on ultrasonography and contrast-enhanced CT and was diagnosed to have histoplasmosis on fine-needle aspiration cytology

Histoplasmosis is an infective condition caused by a

dimorphic saprophytic fungus Histoplasma capsulatum and is acquired by inhalation of its spores Soil rich in bird and bat dropping is its natural habitat and it exists as a mycelium in the atmosphere

Both adrenal gland were enlarged and hypoechoic at US study

US show bilateral hypoechoic lesions and CT showed peripherally enhancing hypodense bilateral adrenals with peripheral rim and septate enhancement

ULTRASOUND OF THE ADULT KIDNEY ndash Normal

Coronal scan plane for the Right Kidney Longitudinal Normal Kidney

Scan plane transverse kidney Transverse normal image

Common anatomical variantsAtrophic small kidneyHorseshoe kidneyEctopic kidneyDuplex kidneyCross fused ectopiaUnilateral renal agenesis

COMMON PATHOLOGYCalculusRenal cyst Cortical and Para-pelvicAngiomyolipmaRenal infectionRenal cell carcinomaTransitional cell carcinomaMedullary sponge kidneyPolycystic kidney disease

Horseshoe kidney A transverse and longitudinal view across the midline showing the isthmus across the aorta

Cross fused ectopic kidney The left kidney is fused to the lower pole of the right kidney

A baggy extra-renal pelvis

Pelvic ectopic kidney

UltrasonographyOn sonograms stones are demonstrated as bright echogenic foci with posterior acoustic shadowing Stones are visualized fairly well with US in the kidneys and the distal ureter at or near the UVJ especially if dilatation is present US is good for the visualization of complications such as hydronephrosis (or other signs of obstruction) however some patients with acute obstruction have little or no dilationIn particular US is helpful in evaluating those with renal insufficiency or contraindications for the use of contrast media however US is often skipped in favor of nonenhanced CTIn addition US is good for characterizing lucent filling defects that are visualized as stones on IVU However US does not provide direct physiologic information regarding the degree of obstruction Doppler imaging may demonstrate a high resistive index in acute obstruction but this may not occur immediately or after forniceal rupture Absence of the ureteral jet as visualized with color Doppler on the symptomatic side is presumptive evidence for a high-grade obstruction in a well-hydrated patient

Degree of confidenceUS is very insensitive for stones especially stones smaller than 2 mm stones at the UPJ or stones in the mid ureter Fowler et al suggest that US has a sensitivity as low as 24 compared with nonenhanced CT Furthermore estimations of stone size may not be accurate Compared with nonenhanced CT US is more dependent on the operators ability and more time consuming

False positivesnegativesUS is fairly specific when stones are seen with a specificity as high as 90 With US matrix or indinavir stones may have soft tissue echogenicity without shadowing False-positive findings may result from renal vascular calcifications False-positive diagnoses of hydronephrosis also result from dilated vascular structures in the renal hilum Doppler imaging is helpful in distinguishing dilated vascular structures from hydronephrosis

Renal sonogram demonstrates an echogenic shadowing calculus in the renal collecting system with hydronephrosis

US images for renal stones

US images of staghorn stones

US images for ureteric stones

US images for nephrocalcinosis

Renal cystA renal cyst is a fluid collection in the kidney There are several types based on the Bosniak classification The majority are benign simple cysts that can be monitored and not intervened upon However some are cancerous or are suspicious for cancer and are commonly removed in a surgical procedure called nephrectomyNumerous renal cysts are seen in the cystic kidney diseases which include polycystic kidney diseaseand medullary sponge kidney

The Bosniak classification categorizes renal cysts into five groupsCategory I

Benign simple cyst with thin wall without septa calcifications or solid

components

It does not enhance with contrast and has a density equal to that of water

Category IIBenign cyst with a few thin septa which may contain fine calcifications or a

small

segment of mildly thickened calcification This includes homogenous

high-attenuation lesions less than 3 cm with sharp margins(Rich Kosak) but

without enhancement

Category IIFWell marginated cysts with a number of thin septa with or without mild

enhancement or thickening of septa Calcifications may be present these

may be thick and nodular There are no enhancing soft tissue components

This also includes nonenhancing high-attenuation lesions that are completely

contained within the kidney and are 3 cm or larger

Category IIIIndeterminate cystic masses with thickened irregular septa with enhancement

Category IVMalignant cystic masses with all the characteristics of category III lesions

but also with enhancing soft tissue components independent of but adjacent

to the septa

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 11)

Classic findings of a simple cyst(Bosniak category 111)

Classic findings of a simple cyst(Bosniak category 1V)

Para-pelvic cyst USamp CT images

US of polycystic kidney disease

Renal infection

US of acute pyelonephritis

Acute bacterial pyelonephritis (a) US scan shows a wedge-shaped hyperechoic focus (arrowhead) in the upper pole of the right kidney related to acute bacterial pyelonephritis (b) Color flow US image demonstrates diminished flow through the involved area

US and color Doppler images of right kidney shows focal hyperechoic nephritis with decreased perfusion at the Doppler US

US and color Doppler images of kidney shows two multifocal nephritis with decreased perfusion at the Doppler US

Masslike appearance of acute bacterial pyelonephritis US and CT images

Emphysematous pyelonephritis (a) US image shows nondependent echoes within the left kidney that demonstrate a ring-down artifact (b) Corresponding CT scan helps confirm that this pattern is caused by intraparenchymal air

Xanthogranulomatous pyelonephritis (a) Contrast-enhanced CT scan demonstrates bilateral staghorn calculi with distention of the right collecting system secondary to inflammatory debris (b) US scan also shows the dilated

collecting system (arrowheads) and a shadowing calculus (arrow)

Early and mature abscess cavities (a) US scan demonstrates a geographic hypoechoic focus from an abscess in the upper pole of the right kidney (b) On a US scan of a more mature abscess the cavity is better defined with a visible pseudocapsule and through transmission that is evidenced by increased echogenicity deep to the upper pole lesion

Pyohydronephrosis

Pyohydronephrosis

Renal hydatidosis is an insidious disease and patients

often present with nonspecific clinical signs or symptoms Presenting complaints are dull flank pain hematuria palpable flank mass hypertension and renal colic

Disseminated abdominal retroperitoneal and pelvic hydatid disease (a) The right kidney is pushed to the midline and the left kidney is hydronephrotic and shrunken by retroperitoneal hydatid cysts (b) Ultrasound of the abdomen showing cystic lesions in the retroperitoneum in the position of the kidneys

Hydatid disease of the kidney US and CT images

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 36: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Incidentaloma An incidentaloma is an adrenal tumour that is detected incidentally in an asymptomatic patient Incidentalomas are found in 1 of CT examinations They are much less common in ultrasound examinations because of the difficulty in defining small lesions (lt 2 cm) The predominantly hypoechoic tumours account for the great majority of incidentalomas shows the algorithm used in the investigation of incidentalomas Approximately 10 to 15 of these tumours are hormonally active In some cases ultrasound-guided fine-needle aspiration can also aid in the evaluation of incidentalomas but only ca 1 to 2 of these tumours are malignant

Abdominal ultrasound examination incidentally found most hypoechoic lesions

smaller 2 cm without clinical symptoms ndash which is typical for incidentalomas

Histoplasmosis is a geographically restricted form of

fungal infection Adrenal involvement is seen in disseminated disease but sometimes it may be the only site of demonstrable disease Early diagnosis and treatment may save the patient from catastrophic adrenal insufficiency We present two patients showing bilateral adrenomegaly on ultrasonography and contrast-enhanced CT and was diagnosed to have histoplasmosis on fine-needle aspiration cytology

Histoplasmosis is an infective condition caused by a

dimorphic saprophytic fungus Histoplasma capsulatum and is acquired by inhalation of its spores Soil rich in bird and bat dropping is its natural habitat and it exists as a mycelium in the atmosphere

Both adrenal gland were enlarged and hypoechoic at US study

US show bilateral hypoechoic lesions and CT showed peripherally enhancing hypodense bilateral adrenals with peripheral rim and septate enhancement

ULTRASOUND OF THE ADULT KIDNEY ndash Normal

Coronal scan plane for the Right Kidney Longitudinal Normal Kidney

Scan plane transverse kidney Transverse normal image

Common anatomical variantsAtrophic small kidneyHorseshoe kidneyEctopic kidneyDuplex kidneyCross fused ectopiaUnilateral renal agenesis

COMMON PATHOLOGYCalculusRenal cyst Cortical and Para-pelvicAngiomyolipmaRenal infectionRenal cell carcinomaTransitional cell carcinomaMedullary sponge kidneyPolycystic kidney disease

Horseshoe kidney A transverse and longitudinal view across the midline showing the isthmus across the aorta

Cross fused ectopic kidney The left kidney is fused to the lower pole of the right kidney

A baggy extra-renal pelvis

Pelvic ectopic kidney

UltrasonographyOn sonograms stones are demonstrated as bright echogenic foci with posterior acoustic shadowing Stones are visualized fairly well with US in the kidneys and the distal ureter at or near the UVJ especially if dilatation is present US is good for the visualization of complications such as hydronephrosis (or other signs of obstruction) however some patients with acute obstruction have little or no dilationIn particular US is helpful in evaluating those with renal insufficiency or contraindications for the use of contrast media however US is often skipped in favor of nonenhanced CTIn addition US is good for characterizing lucent filling defects that are visualized as stones on IVU However US does not provide direct physiologic information regarding the degree of obstruction Doppler imaging may demonstrate a high resistive index in acute obstruction but this may not occur immediately or after forniceal rupture Absence of the ureteral jet as visualized with color Doppler on the symptomatic side is presumptive evidence for a high-grade obstruction in a well-hydrated patient

Degree of confidenceUS is very insensitive for stones especially stones smaller than 2 mm stones at the UPJ or stones in the mid ureter Fowler et al suggest that US has a sensitivity as low as 24 compared with nonenhanced CT Furthermore estimations of stone size may not be accurate Compared with nonenhanced CT US is more dependent on the operators ability and more time consuming

False positivesnegativesUS is fairly specific when stones are seen with a specificity as high as 90 With US matrix or indinavir stones may have soft tissue echogenicity without shadowing False-positive findings may result from renal vascular calcifications False-positive diagnoses of hydronephrosis also result from dilated vascular structures in the renal hilum Doppler imaging is helpful in distinguishing dilated vascular structures from hydronephrosis

Renal sonogram demonstrates an echogenic shadowing calculus in the renal collecting system with hydronephrosis

US images for renal stones

US images of staghorn stones

US images for ureteric stones

US images for nephrocalcinosis

Renal cystA renal cyst is a fluid collection in the kidney There are several types based on the Bosniak classification The majority are benign simple cysts that can be monitored and not intervened upon However some are cancerous or are suspicious for cancer and are commonly removed in a surgical procedure called nephrectomyNumerous renal cysts are seen in the cystic kidney diseases which include polycystic kidney diseaseand medullary sponge kidney

The Bosniak classification categorizes renal cysts into five groupsCategory I

Benign simple cyst with thin wall without septa calcifications or solid

components

It does not enhance with contrast and has a density equal to that of water

Category IIBenign cyst with a few thin septa which may contain fine calcifications or a

small

segment of mildly thickened calcification This includes homogenous

high-attenuation lesions less than 3 cm with sharp margins(Rich Kosak) but

without enhancement

Category IIFWell marginated cysts with a number of thin septa with or without mild

enhancement or thickening of septa Calcifications may be present these

may be thick and nodular There are no enhancing soft tissue components

This also includes nonenhancing high-attenuation lesions that are completely

contained within the kidney and are 3 cm or larger

Category IIIIndeterminate cystic masses with thickened irregular septa with enhancement

Category IVMalignant cystic masses with all the characteristics of category III lesions

but also with enhancing soft tissue components independent of but adjacent

to the septa

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 11)

Classic findings of a simple cyst(Bosniak category 111)

Classic findings of a simple cyst(Bosniak category 1V)

Para-pelvic cyst USamp CT images

US of polycystic kidney disease

Renal infection

US of acute pyelonephritis

Acute bacterial pyelonephritis (a) US scan shows a wedge-shaped hyperechoic focus (arrowhead) in the upper pole of the right kidney related to acute bacterial pyelonephritis (b) Color flow US image demonstrates diminished flow through the involved area

US and color Doppler images of right kidney shows focal hyperechoic nephritis with decreased perfusion at the Doppler US

US and color Doppler images of kidney shows two multifocal nephritis with decreased perfusion at the Doppler US

Masslike appearance of acute bacterial pyelonephritis US and CT images

Emphysematous pyelonephritis (a) US image shows nondependent echoes within the left kidney that demonstrate a ring-down artifact (b) Corresponding CT scan helps confirm that this pattern is caused by intraparenchymal air

Xanthogranulomatous pyelonephritis (a) Contrast-enhanced CT scan demonstrates bilateral staghorn calculi with distention of the right collecting system secondary to inflammatory debris (b) US scan also shows the dilated

collecting system (arrowheads) and a shadowing calculus (arrow)

Early and mature abscess cavities (a) US scan demonstrates a geographic hypoechoic focus from an abscess in the upper pole of the right kidney (b) On a US scan of a more mature abscess the cavity is better defined with a visible pseudocapsule and through transmission that is evidenced by increased echogenicity deep to the upper pole lesion

Pyohydronephrosis

Pyohydronephrosis

Renal hydatidosis is an insidious disease and patients

often present with nonspecific clinical signs or symptoms Presenting complaints are dull flank pain hematuria palpable flank mass hypertension and renal colic

Disseminated abdominal retroperitoneal and pelvic hydatid disease (a) The right kidney is pushed to the midline and the left kidney is hydronephrotic and shrunken by retroperitoneal hydatid cysts (b) Ultrasound of the abdomen showing cystic lesions in the retroperitoneum in the position of the kidneys

Hydatid disease of the kidney US and CT images

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 37: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Abdominal ultrasound examination incidentally found most hypoechoic lesions

smaller 2 cm without clinical symptoms ndash which is typical for incidentalomas

Histoplasmosis is a geographically restricted form of

fungal infection Adrenal involvement is seen in disseminated disease but sometimes it may be the only site of demonstrable disease Early diagnosis and treatment may save the patient from catastrophic adrenal insufficiency We present two patients showing bilateral adrenomegaly on ultrasonography and contrast-enhanced CT and was diagnosed to have histoplasmosis on fine-needle aspiration cytology

Histoplasmosis is an infective condition caused by a

dimorphic saprophytic fungus Histoplasma capsulatum and is acquired by inhalation of its spores Soil rich in bird and bat dropping is its natural habitat and it exists as a mycelium in the atmosphere

Both adrenal gland were enlarged and hypoechoic at US study

US show bilateral hypoechoic lesions and CT showed peripherally enhancing hypodense bilateral adrenals with peripheral rim and septate enhancement

ULTRASOUND OF THE ADULT KIDNEY ndash Normal

Coronal scan plane for the Right Kidney Longitudinal Normal Kidney

Scan plane transverse kidney Transverse normal image

Common anatomical variantsAtrophic small kidneyHorseshoe kidneyEctopic kidneyDuplex kidneyCross fused ectopiaUnilateral renal agenesis

COMMON PATHOLOGYCalculusRenal cyst Cortical and Para-pelvicAngiomyolipmaRenal infectionRenal cell carcinomaTransitional cell carcinomaMedullary sponge kidneyPolycystic kidney disease

Horseshoe kidney A transverse and longitudinal view across the midline showing the isthmus across the aorta

Cross fused ectopic kidney The left kidney is fused to the lower pole of the right kidney

A baggy extra-renal pelvis

Pelvic ectopic kidney

UltrasonographyOn sonograms stones are demonstrated as bright echogenic foci with posterior acoustic shadowing Stones are visualized fairly well with US in the kidneys and the distal ureter at or near the UVJ especially if dilatation is present US is good for the visualization of complications such as hydronephrosis (or other signs of obstruction) however some patients with acute obstruction have little or no dilationIn particular US is helpful in evaluating those with renal insufficiency or contraindications for the use of contrast media however US is often skipped in favor of nonenhanced CTIn addition US is good for characterizing lucent filling defects that are visualized as stones on IVU However US does not provide direct physiologic information regarding the degree of obstruction Doppler imaging may demonstrate a high resistive index in acute obstruction but this may not occur immediately or after forniceal rupture Absence of the ureteral jet as visualized with color Doppler on the symptomatic side is presumptive evidence for a high-grade obstruction in a well-hydrated patient

Degree of confidenceUS is very insensitive for stones especially stones smaller than 2 mm stones at the UPJ or stones in the mid ureter Fowler et al suggest that US has a sensitivity as low as 24 compared with nonenhanced CT Furthermore estimations of stone size may not be accurate Compared with nonenhanced CT US is more dependent on the operators ability and more time consuming

False positivesnegativesUS is fairly specific when stones are seen with a specificity as high as 90 With US matrix or indinavir stones may have soft tissue echogenicity without shadowing False-positive findings may result from renal vascular calcifications False-positive diagnoses of hydronephrosis also result from dilated vascular structures in the renal hilum Doppler imaging is helpful in distinguishing dilated vascular structures from hydronephrosis

Renal sonogram demonstrates an echogenic shadowing calculus in the renal collecting system with hydronephrosis

US images for renal stones

US images of staghorn stones

US images for ureteric stones

US images for nephrocalcinosis

Renal cystA renal cyst is a fluid collection in the kidney There are several types based on the Bosniak classification The majority are benign simple cysts that can be monitored and not intervened upon However some are cancerous or are suspicious for cancer and are commonly removed in a surgical procedure called nephrectomyNumerous renal cysts are seen in the cystic kidney diseases which include polycystic kidney diseaseand medullary sponge kidney

The Bosniak classification categorizes renal cysts into five groupsCategory I

Benign simple cyst with thin wall without septa calcifications or solid

components

It does not enhance with contrast and has a density equal to that of water

Category IIBenign cyst with a few thin septa which may contain fine calcifications or a

small

segment of mildly thickened calcification This includes homogenous

high-attenuation lesions less than 3 cm with sharp margins(Rich Kosak) but

without enhancement

Category IIFWell marginated cysts with a number of thin septa with or without mild

enhancement or thickening of septa Calcifications may be present these

may be thick and nodular There are no enhancing soft tissue components

This also includes nonenhancing high-attenuation lesions that are completely

contained within the kidney and are 3 cm or larger

Category IIIIndeterminate cystic masses with thickened irregular septa with enhancement

Category IVMalignant cystic masses with all the characteristics of category III lesions

but also with enhancing soft tissue components independent of but adjacent

to the septa

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 11)

Classic findings of a simple cyst(Bosniak category 111)

Classic findings of a simple cyst(Bosniak category 1V)

Para-pelvic cyst USamp CT images

US of polycystic kidney disease

Renal infection

US of acute pyelonephritis

Acute bacterial pyelonephritis (a) US scan shows a wedge-shaped hyperechoic focus (arrowhead) in the upper pole of the right kidney related to acute bacterial pyelonephritis (b) Color flow US image demonstrates diminished flow through the involved area

US and color Doppler images of right kidney shows focal hyperechoic nephritis with decreased perfusion at the Doppler US

US and color Doppler images of kidney shows two multifocal nephritis with decreased perfusion at the Doppler US

Masslike appearance of acute bacterial pyelonephritis US and CT images

Emphysematous pyelonephritis (a) US image shows nondependent echoes within the left kidney that demonstrate a ring-down artifact (b) Corresponding CT scan helps confirm that this pattern is caused by intraparenchymal air

Xanthogranulomatous pyelonephritis (a) Contrast-enhanced CT scan demonstrates bilateral staghorn calculi with distention of the right collecting system secondary to inflammatory debris (b) US scan also shows the dilated

collecting system (arrowheads) and a shadowing calculus (arrow)

Early and mature abscess cavities (a) US scan demonstrates a geographic hypoechoic focus from an abscess in the upper pole of the right kidney (b) On a US scan of a more mature abscess the cavity is better defined with a visible pseudocapsule and through transmission that is evidenced by increased echogenicity deep to the upper pole lesion

Pyohydronephrosis

Pyohydronephrosis

Renal hydatidosis is an insidious disease and patients

often present with nonspecific clinical signs or symptoms Presenting complaints are dull flank pain hematuria palpable flank mass hypertension and renal colic

Disseminated abdominal retroperitoneal and pelvic hydatid disease (a) The right kidney is pushed to the midline and the left kidney is hydronephrotic and shrunken by retroperitoneal hydatid cysts (b) Ultrasound of the abdomen showing cystic lesions in the retroperitoneum in the position of the kidneys

Hydatid disease of the kidney US and CT images

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 38: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Histoplasmosis is a geographically restricted form of

fungal infection Adrenal involvement is seen in disseminated disease but sometimes it may be the only site of demonstrable disease Early diagnosis and treatment may save the patient from catastrophic adrenal insufficiency We present two patients showing bilateral adrenomegaly on ultrasonography and contrast-enhanced CT and was diagnosed to have histoplasmosis on fine-needle aspiration cytology

Histoplasmosis is an infective condition caused by a

dimorphic saprophytic fungus Histoplasma capsulatum and is acquired by inhalation of its spores Soil rich in bird and bat dropping is its natural habitat and it exists as a mycelium in the atmosphere

Both adrenal gland were enlarged and hypoechoic at US study

US show bilateral hypoechoic lesions and CT showed peripherally enhancing hypodense bilateral adrenals with peripheral rim and septate enhancement

ULTRASOUND OF THE ADULT KIDNEY ndash Normal

Coronal scan plane for the Right Kidney Longitudinal Normal Kidney

Scan plane transverse kidney Transverse normal image

Common anatomical variantsAtrophic small kidneyHorseshoe kidneyEctopic kidneyDuplex kidneyCross fused ectopiaUnilateral renal agenesis

COMMON PATHOLOGYCalculusRenal cyst Cortical and Para-pelvicAngiomyolipmaRenal infectionRenal cell carcinomaTransitional cell carcinomaMedullary sponge kidneyPolycystic kidney disease

Horseshoe kidney A transverse and longitudinal view across the midline showing the isthmus across the aorta

Cross fused ectopic kidney The left kidney is fused to the lower pole of the right kidney

A baggy extra-renal pelvis

Pelvic ectopic kidney

UltrasonographyOn sonograms stones are demonstrated as bright echogenic foci with posterior acoustic shadowing Stones are visualized fairly well with US in the kidneys and the distal ureter at or near the UVJ especially if dilatation is present US is good for the visualization of complications such as hydronephrosis (or other signs of obstruction) however some patients with acute obstruction have little or no dilationIn particular US is helpful in evaluating those with renal insufficiency or contraindications for the use of contrast media however US is often skipped in favor of nonenhanced CTIn addition US is good for characterizing lucent filling defects that are visualized as stones on IVU However US does not provide direct physiologic information regarding the degree of obstruction Doppler imaging may demonstrate a high resistive index in acute obstruction but this may not occur immediately or after forniceal rupture Absence of the ureteral jet as visualized with color Doppler on the symptomatic side is presumptive evidence for a high-grade obstruction in a well-hydrated patient

Degree of confidenceUS is very insensitive for stones especially stones smaller than 2 mm stones at the UPJ or stones in the mid ureter Fowler et al suggest that US has a sensitivity as low as 24 compared with nonenhanced CT Furthermore estimations of stone size may not be accurate Compared with nonenhanced CT US is more dependent on the operators ability and more time consuming

False positivesnegativesUS is fairly specific when stones are seen with a specificity as high as 90 With US matrix or indinavir stones may have soft tissue echogenicity without shadowing False-positive findings may result from renal vascular calcifications False-positive diagnoses of hydronephrosis also result from dilated vascular structures in the renal hilum Doppler imaging is helpful in distinguishing dilated vascular structures from hydronephrosis

Renal sonogram demonstrates an echogenic shadowing calculus in the renal collecting system with hydronephrosis

US images for renal stones

US images of staghorn stones

US images for ureteric stones

US images for nephrocalcinosis

Renal cystA renal cyst is a fluid collection in the kidney There are several types based on the Bosniak classification The majority are benign simple cysts that can be monitored and not intervened upon However some are cancerous or are suspicious for cancer and are commonly removed in a surgical procedure called nephrectomyNumerous renal cysts are seen in the cystic kidney diseases which include polycystic kidney diseaseand medullary sponge kidney

The Bosniak classification categorizes renal cysts into five groupsCategory I

Benign simple cyst with thin wall without septa calcifications or solid

components

It does not enhance with contrast and has a density equal to that of water

Category IIBenign cyst with a few thin septa which may contain fine calcifications or a

small

segment of mildly thickened calcification This includes homogenous

high-attenuation lesions less than 3 cm with sharp margins(Rich Kosak) but

without enhancement

Category IIFWell marginated cysts with a number of thin septa with or without mild

enhancement or thickening of septa Calcifications may be present these

may be thick and nodular There are no enhancing soft tissue components

This also includes nonenhancing high-attenuation lesions that are completely

contained within the kidney and are 3 cm or larger

Category IIIIndeterminate cystic masses with thickened irregular septa with enhancement

Category IVMalignant cystic masses with all the characteristics of category III lesions

but also with enhancing soft tissue components independent of but adjacent

to the septa

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 11)

Classic findings of a simple cyst(Bosniak category 111)

Classic findings of a simple cyst(Bosniak category 1V)

Para-pelvic cyst USamp CT images

US of polycystic kidney disease

Renal infection

US of acute pyelonephritis

Acute bacterial pyelonephritis (a) US scan shows a wedge-shaped hyperechoic focus (arrowhead) in the upper pole of the right kidney related to acute bacterial pyelonephritis (b) Color flow US image demonstrates diminished flow through the involved area

US and color Doppler images of right kidney shows focal hyperechoic nephritis with decreased perfusion at the Doppler US

US and color Doppler images of kidney shows two multifocal nephritis with decreased perfusion at the Doppler US

Masslike appearance of acute bacterial pyelonephritis US and CT images

Emphysematous pyelonephritis (a) US image shows nondependent echoes within the left kidney that demonstrate a ring-down artifact (b) Corresponding CT scan helps confirm that this pattern is caused by intraparenchymal air

Xanthogranulomatous pyelonephritis (a) Contrast-enhanced CT scan demonstrates bilateral staghorn calculi with distention of the right collecting system secondary to inflammatory debris (b) US scan also shows the dilated

collecting system (arrowheads) and a shadowing calculus (arrow)

Early and mature abscess cavities (a) US scan demonstrates a geographic hypoechoic focus from an abscess in the upper pole of the right kidney (b) On a US scan of a more mature abscess the cavity is better defined with a visible pseudocapsule and through transmission that is evidenced by increased echogenicity deep to the upper pole lesion

Pyohydronephrosis

Pyohydronephrosis

Renal hydatidosis is an insidious disease and patients

often present with nonspecific clinical signs or symptoms Presenting complaints are dull flank pain hematuria palpable flank mass hypertension and renal colic

Disseminated abdominal retroperitoneal and pelvic hydatid disease (a) The right kidney is pushed to the midline and the left kidney is hydronephrotic and shrunken by retroperitoneal hydatid cysts (b) Ultrasound of the abdomen showing cystic lesions in the retroperitoneum in the position of the kidneys

Hydatid disease of the kidney US and CT images

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 39: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Both adrenal gland were enlarged and hypoechoic at US study

US show bilateral hypoechoic lesions and CT showed peripherally enhancing hypodense bilateral adrenals with peripheral rim and septate enhancement

ULTRASOUND OF THE ADULT KIDNEY ndash Normal

Coronal scan plane for the Right Kidney Longitudinal Normal Kidney

Scan plane transverse kidney Transverse normal image

Common anatomical variantsAtrophic small kidneyHorseshoe kidneyEctopic kidneyDuplex kidneyCross fused ectopiaUnilateral renal agenesis

COMMON PATHOLOGYCalculusRenal cyst Cortical and Para-pelvicAngiomyolipmaRenal infectionRenal cell carcinomaTransitional cell carcinomaMedullary sponge kidneyPolycystic kidney disease

Horseshoe kidney A transverse and longitudinal view across the midline showing the isthmus across the aorta

Cross fused ectopic kidney The left kidney is fused to the lower pole of the right kidney

A baggy extra-renal pelvis

Pelvic ectopic kidney

UltrasonographyOn sonograms stones are demonstrated as bright echogenic foci with posterior acoustic shadowing Stones are visualized fairly well with US in the kidneys and the distal ureter at or near the UVJ especially if dilatation is present US is good for the visualization of complications such as hydronephrosis (or other signs of obstruction) however some patients with acute obstruction have little or no dilationIn particular US is helpful in evaluating those with renal insufficiency or contraindications for the use of contrast media however US is often skipped in favor of nonenhanced CTIn addition US is good for characterizing lucent filling defects that are visualized as stones on IVU However US does not provide direct physiologic information regarding the degree of obstruction Doppler imaging may demonstrate a high resistive index in acute obstruction but this may not occur immediately or after forniceal rupture Absence of the ureteral jet as visualized with color Doppler on the symptomatic side is presumptive evidence for a high-grade obstruction in a well-hydrated patient

Degree of confidenceUS is very insensitive for stones especially stones smaller than 2 mm stones at the UPJ or stones in the mid ureter Fowler et al suggest that US has a sensitivity as low as 24 compared with nonenhanced CT Furthermore estimations of stone size may not be accurate Compared with nonenhanced CT US is more dependent on the operators ability and more time consuming

False positivesnegativesUS is fairly specific when stones are seen with a specificity as high as 90 With US matrix or indinavir stones may have soft tissue echogenicity without shadowing False-positive findings may result from renal vascular calcifications False-positive diagnoses of hydronephrosis also result from dilated vascular structures in the renal hilum Doppler imaging is helpful in distinguishing dilated vascular structures from hydronephrosis

Renal sonogram demonstrates an echogenic shadowing calculus in the renal collecting system with hydronephrosis

US images for renal stones

US images of staghorn stones

US images for ureteric stones

US images for nephrocalcinosis

Renal cystA renal cyst is a fluid collection in the kidney There are several types based on the Bosniak classification The majority are benign simple cysts that can be monitored and not intervened upon However some are cancerous or are suspicious for cancer and are commonly removed in a surgical procedure called nephrectomyNumerous renal cysts are seen in the cystic kidney diseases which include polycystic kidney diseaseand medullary sponge kidney

The Bosniak classification categorizes renal cysts into five groupsCategory I

Benign simple cyst with thin wall without septa calcifications or solid

components

It does not enhance with contrast and has a density equal to that of water

Category IIBenign cyst with a few thin septa which may contain fine calcifications or a

small

segment of mildly thickened calcification This includes homogenous

high-attenuation lesions less than 3 cm with sharp margins(Rich Kosak) but

without enhancement

Category IIFWell marginated cysts with a number of thin septa with or without mild

enhancement or thickening of septa Calcifications may be present these

may be thick and nodular There are no enhancing soft tissue components

This also includes nonenhancing high-attenuation lesions that are completely

contained within the kidney and are 3 cm or larger

Category IIIIndeterminate cystic masses with thickened irregular septa with enhancement

Category IVMalignant cystic masses with all the characteristics of category III lesions

but also with enhancing soft tissue components independent of but adjacent

to the septa

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 11)

Classic findings of a simple cyst(Bosniak category 111)

Classic findings of a simple cyst(Bosniak category 1V)

Para-pelvic cyst USamp CT images

US of polycystic kidney disease

Renal infection

US of acute pyelonephritis

Acute bacterial pyelonephritis (a) US scan shows a wedge-shaped hyperechoic focus (arrowhead) in the upper pole of the right kidney related to acute bacterial pyelonephritis (b) Color flow US image demonstrates diminished flow through the involved area

US and color Doppler images of right kidney shows focal hyperechoic nephritis with decreased perfusion at the Doppler US

US and color Doppler images of kidney shows two multifocal nephritis with decreased perfusion at the Doppler US

Masslike appearance of acute bacterial pyelonephritis US and CT images

Emphysematous pyelonephritis (a) US image shows nondependent echoes within the left kidney that demonstrate a ring-down artifact (b) Corresponding CT scan helps confirm that this pattern is caused by intraparenchymal air

Xanthogranulomatous pyelonephritis (a) Contrast-enhanced CT scan demonstrates bilateral staghorn calculi with distention of the right collecting system secondary to inflammatory debris (b) US scan also shows the dilated

collecting system (arrowheads) and a shadowing calculus (arrow)

Early and mature abscess cavities (a) US scan demonstrates a geographic hypoechoic focus from an abscess in the upper pole of the right kidney (b) On a US scan of a more mature abscess the cavity is better defined with a visible pseudocapsule and through transmission that is evidenced by increased echogenicity deep to the upper pole lesion

Pyohydronephrosis

Pyohydronephrosis

Renal hydatidosis is an insidious disease and patients

often present with nonspecific clinical signs or symptoms Presenting complaints are dull flank pain hematuria palpable flank mass hypertension and renal colic

Disseminated abdominal retroperitoneal and pelvic hydatid disease (a) The right kidney is pushed to the midline and the left kidney is hydronephrotic and shrunken by retroperitoneal hydatid cysts (b) Ultrasound of the abdomen showing cystic lesions in the retroperitoneum in the position of the kidneys

Hydatid disease of the kidney US and CT images

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 40: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

US show bilateral hypoechoic lesions and CT showed peripherally enhancing hypodense bilateral adrenals with peripheral rim and septate enhancement

ULTRASOUND OF THE ADULT KIDNEY ndash Normal

Coronal scan plane for the Right Kidney Longitudinal Normal Kidney

Scan plane transverse kidney Transverse normal image

Common anatomical variantsAtrophic small kidneyHorseshoe kidneyEctopic kidneyDuplex kidneyCross fused ectopiaUnilateral renal agenesis

COMMON PATHOLOGYCalculusRenal cyst Cortical and Para-pelvicAngiomyolipmaRenal infectionRenal cell carcinomaTransitional cell carcinomaMedullary sponge kidneyPolycystic kidney disease

Horseshoe kidney A transverse and longitudinal view across the midline showing the isthmus across the aorta

Cross fused ectopic kidney The left kidney is fused to the lower pole of the right kidney

A baggy extra-renal pelvis

Pelvic ectopic kidney

UltrasonographyOn sonograms stones are demonstrated as bright echogenic foci with posterior acoustic shadowing Stones are visualized fairly well with US in the kidneys and the distal ureter at or near the UVJ especially if dilatation is present US is good for the visualization of complications such as hydronephrosis (or other signs of obstruction) however some patients with acute obstruction have little or no dilationIn particular US is helpful in evaluating those with renal insufficiency or contraindications for the use of contrast media however US is often skipped in favor of nonenhanced CTIn addition US is good for characterizing lucent filling defects that are visualized as stones on IVU However US does not provide direct physiologic information regarding the degree of obstruction Doppler imaging may demonstrate a high resistive index in acute obstruction but this may not occur immediately or after forniceal rupture Absence of the ureteral jet as visualized with color Doppler on the symptomatic side is presumptive evidence for a high-grade obstruction in a well-hydrated patient

Degree of confidenceUS is very insensitive for stones especially stones smaller than 2 mm stones at the UPJ or stones in the mid ureter Fowler et al suggest that US has a sensitivity as low as 24 compared with nonenhanced CT Furthermore estimations of stone size may not be accurate Compared with nonenhanced CT US is more dependent on the operators ability and more time consuming

False positivesnegativesUS is fairly specific when stones are seen with a specificity as high as 90 With US matrix or indinavir stones may have soft tissue echogenicity without shadowing False-positive findings may result from renal vascular calcifications False-positive diagnoses of hydronephrosis also result from dilated vascular structures in the renal hilum Doppler imaging is helpful in distinguishing dilated vascular structures from hydronephrosis

Renal sonogram demonstrates an echogenic shadowing calculus in the renal collecting system with hydronephrosis

US images for renal stones

US images of staghorn stones

US images for ureteric stones

US images for nephrocalcinosis

Renal cystA renal cyst is a fluid collection in the kidney There are several types based on the Bosniak classification The majority are benign simple cysts that can be monitored and not intervened upon However some are cancerous or are suspicious for cancer and are commonly removed in a surgical procedure called nephrectomyNumerous renal cysts are seen in the cystic kidney diseases which include polycystic kidney diseaseand medullary sponge kidney

The Bosniak classification categorizes renal cysts into five groupsCategory I

Benign simple cyst with thin wall without septa calcifications or solid

components

It does not enhance with contrast and has a density equal to that of water

Category IIBenign cyst with a few thin septa which may contain fine calcifications or a

small

segment of mildly thickened calcification This includes homogenous

high-attenuation lesions less than 3 cm with sharp margins(Rich Kosak) but

without enhancement

Category IIFWell marginated cysts with a number of thin septa with or without mild

enhancement or thickening of septa Calcifications may be present these

may be thick and nodular There are no enhancing soft tissue components

This also includes nonenhancing high-attenuation lesions that are completely

contained within the kidney and are 3 cm or larger

Category IIIIndeterminate cystic masses with thickened irregular septa with enhancement

Category IVMalignant cystic masses with all the characteristics of category III lesions

but also with enhancing soft tissue components independent of but adjacent

to the septa

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 11)

Classic findings of a simple cyst(Bosniak category 111)

Classic findings of a simple cyst(Bosniak category 1V)

Para-pelvic cyst USamp CT images

US of polycystic kidney disease

Renal infection

US of acute pyelonephritis

Acute bacterial pyelonephritis (a) US scan shows a wedge-shaped hyperechoic focus (arrowhead) in the upper pole of the right kidney related to acute bacterial pyelonephritis (b) Color flow US image demonstrates diminished flow through the involved area

US and color Doppler images of right kidney shows focal hyperechoic nephritis with decreased perfusion at the Doppler US

US and color Doppler images of kidney shows two multifocal nephritis with decreased perfusion at the Doppler US

Masslike appearance of acute bacterial pyelonephritis US and CT images

Emphysematous pyelonephritis (a) US image shows nondependent echoes within the left kidney that demonstrate a ring-down artifact (b) Corresponding CT scan helps confirm that this pattern is caused by intraparenchymal air

Xanthogranulomatous pyelonephritis (a) Contrast-enhanced CT scan demonstrates bilateral staghorn calculi with distention of the right collecting system secondary to inflammatory debris (b) US scan also shows the dilated

collecting system (arrowheads) and a shadowing calculus (arrow)

Early and mature abscess cavities (a) US scan demonstrates a geographic hypoechoic focus from an abscess in the upper pole of the right kidney (b) On a US scan of a more mature abscess the cavity is better defined with a visible pseudocapsule and through transmission that is evidenced by increased echogenicity deep to the upper pole lesion

Pyohydronephrosis

Pyohydronephrosis

Renal hydatidosis is an insidious disease and patients

often present with nonspecific clinical signs or symptoms Presenting complaints are dull flank pain hematuria palpable flank mass hypertension and renal colic

Disseminated abdominal retroperitoneal and pelvic hydatid disease (a) The right kidney is pushed to the midline and the left kidney is hydronephrotic and shrunken by retroperitoneal hydatid cysts (b) Ultrasound of the abdomen showing cystic lesions in the retroperitoneum in the position of the kidneys

Hydatid disease of the kidney US and CT images

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 41: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

ULTRASOUND OF THE ADULT KIDNEY ndash Normal

Coronal scan plane for the Right Kidney Longitudinal Normal Kidney

Scan plane transverse kidney Transverse normal image

Common anatomical variantsAtrophic small kidneyHorseshoe kidneyEctopic kidneyDuplex kidneyCross fused ectopiaUnilateral renal agenesis

COMMON PATHOLOGYCalculusRenal cyst Cortical and Para-pelvicAngiomyolipmaRenal infectionRenal cell carcinomaTransitional cell carcinomaMedullary sponge kidneyPolycystic kidney disease

Horseshoe kidney A transverse and longitudinal view across the midline showing the isthmus across the aorta

Cross fused ectopic kidney The left kidney is fused to the lower pole of the right kidney

A baggy extra-renal pelvis

Pelvic ectopic kidney

UltrasonographyOn sonograms stones are demonstrated as bright echogenic foci with posterior acoustic shadowing Stones are visualized fairly well with US in the kidneys and the distal ureter at or near the UVJ especially if dilatation is present US is good for the visualization of complications such as hydronephrosis (or other signs of obstruction) however some patients with acute obstruction have little or no dilationIn particular US is helpful in evaluating those with renal insufficiency or contraindications for the use of contrast media however US is often skipped in favor of nonenhanced CTIn addition US is good for characterizing lucent filling defects that are visualized as stones on IVU However US does not provide direct physiologic information regarding the degree of obstruction Doppler imaging may demonstrate a high resistive index in acute obstruction but this may not occur immediately or after forniceal rupture Absence of the ureteral jet as visualized with color Doppler on the symptomatic side is presumptive evidence for a high-grade obstruction in a well-hydrated patient

Degree of confidenceUS is very insensitive for stones especially stones smaller than 2 mm stones at the UPJ or stones in the mid ureter Fowler et al suggest that US has a sensitivity as low as 24 compared with nonenhanced CT Furthermore estimations of stone size may not be accurate Compared with nonenhanced CT US is more dependent on the operators ability and more time consuming

False positivesnegativesUS is fairly specific when stones are seen with a specificity as high as 90 With US matrix or indinavir stones may have soft tissue echogenicity without shadowing False-positive findings may result from renal vascular calcifications False-positive diagnoses of hydronephrosis also result from dilated vascular structures in the renal hilum Doppler imaging is helpful in distinguishing dilated vascular structures from hydronephrosis

Renal sonogram demonstrates an echogenic shadowing calculus in the renal collecting system with hydronephrosis

US images for renal stones

US images of staghorn stones

US images for ureteric stones

US images for nephrocalcinosis

Renal cystA renal cyst is a fluid collection in the kidney There are several types based on the Bosniak classification The majority are benign simple cysts that can be monitored and not intervened upon However some are cancerous or are suspicious for cancer and are commonly removed in a surgical procedure called nephrectomyNumerous renal cysts are seen in the cystic kidney diseases which include polycystic kidney diseaseand medullary sponge kidney

The Bosniak classification categorizes renal cysts into five groupsCategory I

Benign simple cyst with thin wall without septa calcifications or solid

components

It does not enhance with contrast and has a density equal to that of water

Category IIBenign cyst with a few thin septa which may contain fine calcifications or a

small

segment of mildly thickened calcification This includes homogenous

high-attenuation lesions less than 3 cm with sharp margins(Rich Kosak) but

without enhancement

Category IIFWell marginated cysts with a number of thin septa with or without mild

enhancement or thickening of septa Calcifications may be present these

may be thick and nodular There are no enhancing soft tissue components

This also includes nonenhancing high-attenuation lesions that are completely

contained within the kidney and are 3 cm or larger

Category IIIIndeterminate cystic masses with thickened irregular septa with enhancement

Category IVMalignant cystic masses with all the characteristics of category III lesions

but also with enhancing soft tissue components independent of but adjacent

to the septa

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 11)

Classic findings of a simple cyst(Bosniak category 111)

Classic findings of a simple cyst(Bosniak category 1V)

Para-pelvic cyst USamp CT images

US of polycystic kidney disease

Renal infection

US of acute pyelonephritis

Acute bacterial pyelonephritis (a) US scan shows a wedge-shaped hyperechoic focus (arrowhead) in the upper pole of the right kidney related to acute bacterial pyelonephritis (b) Color flow US image demonstrates diminished flow through the involved area

US and color Doppler images of right kidney shows focal hyperechoic nephritis with decreased perfusion at the Doppler US

US and color Doppler images of kidney shows two multifocal nephritis with decreased perfusion at the Doppler US

Masslike appearance of acute bacterial pyelonephritis US and CT images

Emphysematous pyelonephritis (a) US image shows nondependent echoes within the left kidney that demonstrate a ring-down artifact (b) Corresponding CT scan helps confirm that this pattern is caused by intraparenchymal air

Xanthogranulomatous pyelonephritis (a) Contrast-enhanced CT scan demonstrates bilateral staghorn calculi with distention of the right collecting system secondary to inflammatory debris (b) US scan also shows the dilated

collecting system (arrowheads) and a shadowing calculus (arrow)

Early and mature abscess cavities (a) US scan demonstrates a geographic hypoechoic focus from an abscess in the upper pole of the right kidney (b) On a US scan of a more mature abscess the cavity is better defined with a visible pseudocapsule and through transmission that is evidenced by increased echogenicity deep to the upper pole lesion

Pyohydronephrosis

Pyohydronephrosis

Renal hydatidosis is an insidious disease and patients

often present with nonspecific clinical signs or symptoms Presenting complaints are dull flank pain hematuria palpable flank mass hypertension and renal colic

Disseminated abdominal retroperitoneal and pelvic hydatid disease (a) The right kidney is pushed to the midline and the left kidney is hydronephrotic and shrunken by retroperitoneal hydatid cysts (b) Ultrasound of the abdomen showing cystic lesions in the retroperitoneum in the position of the kidneys

Hydatid disease of the kidney US and CT images

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 42: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Scan plane transverse kidney Transverse normal image

Common anatomical variantsAtrophic small kidneyHorseshoe kidneyEctopic kidneyDuplex kidneyCross fused ectopiaUnilateral renal agenesis

COMMON PATHOLOGYCalculusRenal cyst Cortical and Para-pelvicAngiomyolipmaRenal infectionRenal cell carcinomaTransitional cell carcinomaMedullary sponge kidneyPolycystic kidney disease

Horseshoe kidney A transverse and longitudinal view across the midline showing the isthmus across the aorta

Cross fused ectopic kidney The left kidney is fused to the lower pole of the right kidney

A baggy extra-renal pelvis

Pelvic ectopic kidney

UltrasonographyOn sonograms stones are demonstrated as bright echogenic foci with posterior acoustic shadowing Stones are visualized fairly well with US in the kidneys and the distal ureter at or near the UVJ especially if dilatation is present US is good for the visualization of complications such as hydronephrosis (or other signs of obstruction) however some patients with acute obstruction have little or no dilationIn particular US is helpful in evaluating those with renal insufficiency or contraindications for the use of contrast media however US is often skipped in favor of nonenhanced CTIn addition US is good for characterizing lucent filling defects that are visualized as stones on IVU However US does not provide direct physiologic information regarding the degree of obstruction Doppler imaging may demonstrate a high resistive index in acute obstruction but this may not occur immediately or after forniceal rupture Absence of the ureteral jet as visualized with color Doppler on the symptomatic side is presumptive evidence for a high-grade obstruction in a well-hydrated patient

Degree of confidenceUS is very insensitive for stones especially stones smaller than 2 mm stones at the UPJ or stones in the mid ureter Fowler et al suggest that US has a sensitivity as low as 24 compared with nonenhanced CT Furthermore estimations of stone size may not be accurate Compared with nonenhanced CT US is more dependent on the operators ability and more time consuming

False positivesnegativesUS is fairly specific when stones are seen with a specificity as high as 90 With US matrix or indinavir stones may have soft tissue echogenicity without shadowing False-positive findings may result from renal vascular calcifications False-positive diagnoses of hydronephrosis also result from dilated vascular structures in the renal hilum Doppler imaging is helpful in distinguishing dilated vascular structures from hydronephrosis

Renal sonogram demonstrates an echogenic shadowing calculus in the renal collecting system with hydronephrosis

US images for renal stones

US images of staghorn stones

US images for ureteric stones

US images for nephrocalcinosis

Renal cystA renal cyst is a fluid collection in the kidney There are several types based on the Bosniak classification The majority are benign simple cysts that can be monitored and not intervened upon However some are cancerous or are suspicious for cancer and are commonly removed in a surgical procedure called nephrectomyNumerous renal cysts are seen in the cystic kidney diseases which include polycystic kidney diseaseand medullary sponge kidney

The Bosniak classification categorizes renal cysts into five groupsCategory I

Benign simple cyst with thin wall without septa calcifications or solid

components

It does not enhance with contrast and has a density equal to that of water

Category IIBenign cyst with a few thin septa which may contain fine calcifications or a

small

segment of mildly thickened calcification This includes homogenous

high-attenuation lesions less than 3 cm with sharp margins(Rich Kosak) but

without enhancement

Category IIFWell marginated cysts with a number of thin septa with or without mild

enhancement or thickening of septa Calcifications may be present these

may be thick and nodular There are no enhancing soft tissue components

This also includes nonenhancing high-attenuation lesions that are completely

contained within the kidney and are 3 cm or larger

Category IIIIndeterminate cystic masses with thickened irregular septa with enhancement

Category IVMalignant cystic masses with all the characteristics of category III lesions

but also with enhancing soft tissue components independent of but adjacent

to the septa

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 11)

Classic findings of a simple cyst(Bosniak category 111)

Classic findings of a simple cyst(Bosniak category 1V)

Para-pelvic cyst USamp CT images

US of polycystic kidney disease

Renal infection

US of acute pyelonephritis

Acute bacterial pyelonephritis (a) US scan shows a wedge-shaped hyperechoic focus (arrowhead) in the upper pole of the right kidney related to acute bacterial pyelonephritis (b) Color flow US image demonstrates diminished flow through the involved area

US and color Doppler images of right kidney shows focal hyperechoic nephritis with decreased perfusion at the Doppler US

US and color Doppler images of kidney shows two multifocal nephritis with decreased perfusion at the Doppler US

Masslike appearance of acute bacterial pyelonephritis US and CT images

Emphysematous pyelonephritis (a) US image shows nondependent echoes within the left kidney that demonstrate a ring-down artifact (b) Corresponding CT scan helps confirm that this pattern is caused by intraparenchymal air

Xanthogranulomatous pyelonephritis (a) Contrast-enhanced CT scan demonstrates bilateral staghorn calculi with distention of the right collecting system secondary to inflammatory debris (b) US scan also shows the dilated

collecting system (arrowheads) and a shadowing calculus (arrow)

Early and mature abscess cavities (a) US scan demonstrates a geographic hypoechoic focus from an abscess in the upper pole of the right kidney (b) On a US scan of a more mature abscess the cavity is better defined with a visible pseudocapsule and through transmission that is evidenced by increased echogenicity deep to the upper pole lesion

Pyohydronephrosis

Pyohydronephrosis

Renal hydatidosis is an insidious disease and patients

often present with nonspecific clinical signs or symptoms Presenting complaints are dull flank pain hematuria palpable flank mass hypertension and renal colic

Disseminated abdominal retroperitoneal and pelvic hydatid disease (a) The right kidney is pushed to the midline and the left kidney is hydronephrotic and shrunken by retroperitoneal hydatid cysts (b) Ultrasound of the abdomen showing cystic lesions in the retroperitoneum in the position of the kidneys

Hydatid disease of the kidney US and CT images

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 43: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Common anatomical variantsAtrophic small kidneyHorseshoe kidneyEctopic kidneyDuplex kidneyCross fused ectopiaUnilateral renal agenesis

COMMON PATHOLOGYCalculusRenal cyst Cortical and Para-pelvicAngiomyolipmaRenal infectionRenal cell carcinomaTransitional cell carcinomaMedullary sponge kidneyPolycystic kidney disease

Horseshoe kidney A transverse and longitudinal view across the midline showing the isthmus across the aorta

Cross fused ectopic kidney The left kidney is fused to the lower pole of the right kidney

A baggy extra-renal pelvis

Pelvic ectopic kidney

UltrasonographyOn sonograms stones are demonstrated as bright echogenic foci with posterior acoustic shadowing Stones are visualized fairly well with US in the kidneys and the distal ureter at or near the UVJ especially if dilatation is present US is good for the visualization of complications such as hydronephrosis (or other signs of obstruction) however some patients with acute obstruction have little or no dilationIn particular US is helpful in evaluating those with renal insufficiency or contraindications for the use of contrast media however US is often skipped in favor of nonenhanced CTIn addition US is good for characterizing lucent filling defects that are visualized as stones on IVU However US does not provide direct physiologic information regarding the degree of obstruction Doppler imaging may demonstrate a high resistive index in acute obstruction but this may not occur immediately or after forniceal rupture Absence of the ureteral jet as visualized with color Doppler on the symptomatic side is presumptive evidence for a high-grade obstruction in a well-hydrated patient

Degree of confidenceUS is very insensitive for stones especially stones smaller than 2 mm stones at the UPJ or stones in the mid ureter Fowler et al suggest that US has a sensitivity as low as 24 compared with nonenhanced CT Furthermore estimations of stone size may not be accurate Compared with nonenhanced CT US is more dependent on the operators ability and more time consuming

False positivesnegativesUS is fairly specific when stones are seen with a specificity as high as 90 With US matrix or indinavir stones may have soft tissue echogenicity without shadowing False-positive findings may result from renal vascular calcifications False-positive diagnoses of hydronephrosis also result from dilated vascular structures in the renal hilum Doppler imaging is helpful in distinguishing dilated vascular structures from hydronephrosis

Renal sonogram demonstrates an echogenic shadowing calculus in the renal collecting system with hydronephrosis

US images for renal stones

US images of staghorn stones

US images for ureteric stones

US images for nephrocalcinosis

Renal cystA renal cyst is a fluid collection in the kidney There are several types based on the Bosniak classification The majority are benign simple cysts that can be monitored and not intervened upon However some are cancerous or are suspicious for cancer and are commonly removed in a surgical procedure called nephrectomyNumerous renal cysts are seen in the cystic kidney diseases which include polycystic kidney diseaseand medullary sponge kidney

The Bosniak classification categorizes renal cysts into five groupsCategory I

Benign simple cyst with thin wall without septa calcifications or solid

components

It does not enhance with contrast and has a density equal to that of water

Category IIBenign cyst with a few thin septa which may contain fine calcifications or a

small

segment of mildly thickened calcification This includes homogenous

high-attenuation lesions less than 3 cm with sharp margins(Rich Kosak) but

without enhancement

Category IIFWell marginated cysts with a number of thin septa with or without mild

enhancement or thickening of septa Calcifications may be present these

may be thick and nodular There are no enhancing soft tissue components

This also includes nonenhancing high-attenuation lesions that are completely

contained within the kidney and are 3 cm or larger

Category IIIIndeterminate cystic masses with thickened irregular septa with enhancement

Category IVMalignant cystic masses with all the characteristics of category III lesions

but also with enhancing soft tissue components independent of but adjacent

to the septa

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 11)

Classic findings of a simple cyst(Bosniak category 111)

Classic findings of a simple cyst(Bosniak category 1V)

Para-pelvic cyst USamp CT images

US of polycystic kidney disease

Renal infection

US of acute pyelonephritis

Acute bacterial pyelonephritis (a) US scan shows a wedge-shaped hyperechoic focus (arrowhead) in the upper pole of the right kidney related to acute bacterial pyelonephritis (b) Color flow US image demonstrates diminished flow through the involved area

US and color Doppler images of right kidney shows focal hyperechoic nephritis with decreased perfusion at the Doppler US

US and color Doppler images of kidney shows two multifocal nephritis with decreased perfusion at the Doppler US

Masslike appearance of acute bacterial pyelonephritis US and CT images

Emphysematous pyelonephritis (a) US image shows nondependent echoes within the left kidney that demonstrate a ring-down artifact (b) Corresponding CT scan helps confirm that this pattern is caused by intraparenchymal air

Xanthogranulomatous pyelonephritis (a) Contrast-enhanced CT scan demonstrates bilateral staghorn calculi with distention of the right collecting system secondary to inflammatory debris (b) US scan also shows the dilated

collecting system (arrowheads) and a shadowing calculus (arrow)

Early and mature abscess cavities (a) US scan demonstrates a geographic hypoechoic focus from an abscess in the upper pole of the right kidney (b) On a US scan of a more mature abscess the cavity is better defined with a visible pseudocapsule and through transmission that is evidenced by increased echogenicity deep to the upper pole lesion

Pyohydronephrosis

Pyohydronephrosis

Renal hydatidosis is an insidious disease and patients

often present with nonspecific clinical signs or symptoms Presenting complaints are dull flank pain hematuria palpable flank mass hypertension and renal colic

Disseminated abdominal retroperitoneal and pelvic hydatid disease (a) The right kidney is pushed to the midline and the left kidney is hydronephrotic and shrunken by retroperitoneal hydatid cysts (b) Ultrasound of the abdomen showing cystic lesions in the retroperitoneum in the position of the kidneys

Hydatid disease of the kidney US and CT images

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 44: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Horseshoe kidney A transverse and longitudinal view across the midline showing the isthmus across the aorta

Cross fused ectopic kidney The left kidney is fused to the lower pole of the right kidney

A baggy extra-renal pelvis

Pelvic ectopic kidney

UltrasonographyOn sonograms stones are demonstrated as bright echogenic foci with posterior acoustic shadowing Stones are visualized fairly well with US in the kidneys and the distal ureter at or near the UVJ especially if dilatation is present US is good for the visualization of complications such as hydronephrosis (or other signs of obstruction) however some patients with acute obstruction have little or no dilationIn particular US is helpful in evaluating those with renal insufficiency or contraindications for the use of contrast media however US is often skipped in favor of nonenhanced CTIn addition US is good for characterizing lucent filling defects that are visualized as stones on IVU However US does not provide direct physiologic information regarding the degree of obstruction Doppler imaging may demonstrate a high resistive index in acute obstruction but this may not occur immediately or after forniceal rupture Absence of the ureteral jet as visualized with color Doppler on the symptomatic side is presumptive evidence for a high-grade obstruction in a well-hydrated patient

Degree of confidenceUS is very insensitive for stones especially stones smaller than 2 mm stones at the UPJ or stones in the mid ureter Fowler et al suggest that US has a sensitivity as low as 24 compared with nonenhanced CT Furthermore estimations of stone size may not be accurate Compared with nonenhanced CT US is more dependent on the operators ability and more time consuming

False positivesnegativesUS is fairly specific when stones are seen with a specificity as high as 90 With US matrix or indinavir stones may have soft tissue echogenicity without shadowing False-positive findings may result from renal vascular calcifications False-positive diagnoses of hydronephrosis also result from dilated vascular structures in the renal hilum Doppler imaging is helpful in distinguishing dilated vascular structures from hydronephrosis

Renal sonogram demonstrates an echogenic shadowing calculus in the renal collecting system with hydronephrosis

US images for renal stones

US images of staghorn stones

US images for ureteric stones

US images for nephrocalcinosis

Renal cystA renal cyst is a fluid collection in the kidney There are several types based on the Bosniak classification The majority are benign simple cysts that can be monitored and not intervened upon However some are cancerous or are suspicious for cancer and are commonly removed in a surgical procedure called nephrectomyNumerous renal cysts are seen in the cystic kidney diseases which include polycystic kidney diseaseand medullary sponge kidney

The Bosniak classification categorizes renal cysts into five groupsCategory I

Benign simple cyst with thin wall without septa calcifications or solid

components

It does not enhance with contrast and has a density equal to that of water

Category IIBenign cyst with a few thin septa which may contain fine calcifications or a

small

segment of mildly thickened calcification This includes homogenous

high-attenuation lesions less than 3 cm with sharp margins(Rich Kosak) but

without enhancement

Category IIFWell marginated cysts with a number of thin septa with or without mild

enhancement or thickening of septa Calcifications may be present these

may be thick and nodular There are no enhancing soft tissue components

This also includes nonenhancing high-attenuation lesions that are completely

contained within the kidney and are 3 cm or larger

Category IIIIndeterminate cystic masses with thickened irregular septa with enhancement

Category IVMalignant cystic masses with all the characteristics of category III lesions

but also with enhancing soft tissue components independent of but adjacent

to the septa

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 11)

Classic findings of a simple cyst(Bosniak category 111)

Classic findings of a simple cyst(Bosniak category 1V)

Para-pelvic cyst USamp CT images

US of polycystic kidney disease

Renal infection

US of acute pyelonephritis

Acute bacterial pyelonephritis (a) US scan shows a wedge-shaped hyperechoic focus (arrowhead) in the upper pole of the right kidney related to acute bacterial pyelonephritis (b) Color flow US image demonstrates diminished flow through the involved area

US and color Doppler images of right kidney shows focal hyperechoic nephritis with decreased perfusion at the Doppler US

US and color Doppler images of kidney shows two multifocal nephritis with decreased perfusion at the Doppler US

Masslike appearance of acute bacterial pyelonephritis US and CT images

Emphysematous pyelonephritis (a) US image shows nondependent echoes within the left kidney that demonstrate a ring-down artifact (b) Corresponding CT scan helps confirm that this pattern is caused by intraparenchymal air

Xanthogranulomatous pyelonephritis (a) Contrast-enhanced CT scan demonstrates bilateral staghorn calculi with distention of the right collecting system secondary to inflammatory debris (b) US scan also shows the dilated

collecting system (arrowheads) and a shadowing calculus (arrow)

Early and mature abscess cavities (a) US scan demonstrates a geographic hypoechoic focus from an abscess in the upper pole of the right kidney (b) On a US scan of a more mature abscess the cavity is better defined with a visible pseudocapsule and through transmission that is evidenced by increased echogenicity deep to the upper pole lesion

Pyohydronephrosis

Pyohydronephrosis

Renal hydatidosis is an insidious disease and patients

often present with nonspecific clinical signs or symptoms Presenting complaints are dull flank pain hematuria palpable flank mass hypertension and renal colic

Disseminated abdominal retroperitoneal and pelvic hydatid disease (a) The right kidney is pushed to the midline and the left kidney is hydronephrotic and shrunken by retroperitoneal hydatid cysts (b) Ultrasound of the abdomen showing cystic lesions in the retroperitoneum in the position of the kidneys

Hydatid disease of the kidney US and CT images

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 45: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Cross fused ectopic kidney The left kidney is fused to the lower pole of the right kidney

A baggy extra-renal pelvis

Pelvic ectopic kidney

UltrasonographyOn sonograms stones are demonstrated as bright echogenic foci with posterior acoustic shadowing Stones are visualized fairly well with US in the kidneys and the distal ureter at or near the UVJ especially if dilatation is present US is good for the visualization of complications such as hydronephrosis (or other signs of obstruction) however some patients with acute obstruction have little or no dilationIn particular US is helpful in evaluating those with renal insufficiency or contraindications for the use of contrast media however US is often skipped in favor of nonenhanced CTIn addition US is good for characterizing lucent filling defects that are visualized as stones on IVU However US does not provide direct physiologic information regarding the degree of obstruction Doppler imaging may demonstrate a high resistive index in acute obstruction but this may not occur immediately or after forniceal rupture Absence of the ureteral jet as visualized with color Doppler on the symptomatic side is presumptive evidence for a high-grade obstruction in a well-hydrated patient

Degree of confidenceUS is very insensitive for stones especially stones smaller than 2 mm stones at the UPJ or stones in the mid ureter Fowler et al suggest that US has a sensitivity as low as 24 compared with nonenhanced CT Furthermore estimations of stone size may not be accurate Compared with nonenhanced CT US is more dependent on the operators ability and more time consuming

False positivesnegativesUS is fairly specific when stones are seen with a specificity as high as 90 With US matrix or indinavir stones may have soft tissue echogenicity without shadowing False-positive findings may result from renal vascular calcifications False-positive diagnoses of hydronephrosis also result from dilated vascular structures in the renal hilum Doppler imaging is helpful in distinguishing dilated vascular structures from hydronephrosis

Renal sonogram demonstrates an echogenic shadowing calculus in the renal collecting system with hydronephrosis

US images for renal stones

US images of staghorn stones

US images for ureteric stones

US images for nephrocalcinosis

Renal cystA renal cyst is a fluid collection in the kidney There are several types based on the Bosniak classification The majority are benign simple cysts that can be monitored and not intervened upon However some are cancerous or are suspicious for cancer and are commonly removed in a surgical procedure called nephrectomyNumerous renal cysts are seen in the cystic kidney diseases which include polycystic kidney diseaseand medullary sponge kidney

The Bosniak classification categorizes renal cysts into five groupsCategory I

Benign simple cyst with thin wall without septa calcifications or solid

components

It does not enhance with contrast and has a density equal to that of water

Category IIBenign cyst with a few thin septa which may contain fine calcifications or a

small

segment of mildly thickened calcification This includes homogenous

high-attenuation lesions less than 3 cm with sharp margins(Rich Kosak) but

without enhancement

Category IIFWell marginated cysts with a number of thin septa with or without mild

enhancement or thickening of septa Calcifications may be present these

may be thick and nodular There are no enhancing soft tissue components

This also includes nonenhancing high-attenuation lesions that are completely

contained within the kidney and are 3 cm or larger

Category IIIIndeterminate cystic masses with thickened irregular septa with enhancement

Category IVMalignant cystic masses with all the characteristics of category III lesions

but also with enhancing soft tissue components independent of but adjacent

to the septa

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 11)

Classic findings of a simple cyst(Bosniak category 111)

Classic findings of a simple cyst(Bosniak category 1V)

Para-pelvic cyst USamp CT images

US of polycystic kidney disease

Renal infection

US of acute pyelonephritis

Acute bacterial pyelonephritis (a) US scan shows a wedge-shaped hyperechoic focus (arrowhead) in the upper pole of the right kidney related to acute bacterial pyelonephritis (b) Color flow US image demonstrates diminished flow through the involved area

US and color Doppler images of right kidney shows focal hyperechoic nephritis with decreased perfusion at the Doppler US

US and color Doppler images of kidney shows two multifocal nephritis with decreased perfusion at the Doppler US

Masslike appearance of acute bacterial pyelonephritis US and CT images

Emphysematous pyelonephritis (a) US image shows nondependent echoes within the left kidney that demonstrate a ring-down artifact (b) Corresponding CT scan helps confirm that this pattern is caused by intraparenchymal air

Xanthogranulomatous pyelonephritis (a) Contrast-enhanced CT scan demonstrates bilateral staghorn calculi with distention of the right collecting system secondary to inflammatory debris (b) US scan also shows the dilated

collecting system (arrowheads) and a shadowing calculus (arrow)

Early and mature abscess cavities (a) US scan demonstrates a geographic hypoechoic focus from an abscess in the upper pole of the right kidney (b) On a US scan of a more mature abscess the cavity is better defined with a visible pseudocapsule and through transmission that is evidenced by increased echogenicity deep to the upper pole lesion

Pyohydronephrosis

Pyohydronephrosis

Renal hydatidosis is an insidious disease and patients

often present with nonspecific clinical signs or symptoms Presenting complaints are dull flank pain hematuria palpable flank mass hypertension and renal colic

Disseminated abdominal retroperitoneal and pelvic hydatid disease (a) The right kidney is pushed to the midline and the left kidney is hydronephrotic and shrunken by retroperitoneal hydatid cysts (b) Ultrasound of the abdomen showing cystic lesions in the retroperitoneum in the position of the kidneys

Hydatid disease of the kidney US and CT images

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 46: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

A baggy extra-renal pelvis

Pelvic ectopic kidney

UltrasonographyOn sonograms stones are demonstrated as bright echogenic foci with posterior acoustic shadowing Stones are visualized fairly well with US in the kidneys and the distal ureter at or near the UVJ especially if dilatation is present US is good for the visualization of complications such as hydronephrosis (or other signs of obstruction) however some patients with acute obstruction have little or no dilationIn particular US is helpful in evaluating those with renal insufficiency or contraindications for the use of contrast media however US is often skipped in favor of nonenhanced CTIn addition US is good for characterizing lucent filling defects that are visualized as stones on IVU However US does not provide direct physiologic information regarding the degree of obstruction Doppler imaging may demonstrate a high resistive index in acute obstruction but this may not occur immediately or after forniceal rupture Absence of the ureteral jet as visualized with color Doppler on the symptomatic side is presumptive evidence for a high-grade obstruction in a well-hydrated patient

Degree of confidenceUS is very insensitive for stones especially stones smaller than 2 mm stones at the UPJ or stones in the mid ureter Fowler et al suggest that US has a sensitivity as low as 24 compared with nonenhanced CT Furthermore estimations of stone size may not be accurate Compared with nonenhanced CT US is more dependent on the operators ability and more time consuming

False positivesnegativesUS is fairly specific when stones are seen with a specificity as high as 90 With US matrix or indinavir stones may have soft tissue echogenicity without shadowing False-positive findings may result from renal vascular calcifications False-positive diagnoses of hydronephrosis also result from dilated vascular structures in the renal hilum Doppler imaging is helpful in distinguishing dilated vascular structures from hydronephrosis

Renal sonogram demonstrates an echogenic shadowing calculus in the renal collecting system with hydronephrosis

US images for renal stones

US images of staghorn stones

US images for ureteric stones

US images for nephrocalcinosis

Renal cystA renal cyst is a fluid collection in the kidney There are several types based on the Bosniak classification The majority are benign simple cysts that can be monitored and not intervened upon However some are cancerous or are suspicious for cancer and are commonly removed in a surgical procedure called nephrectomyNumerous renal cysts are seen in the cystic kidney diseases which include polycystic kidney diseaseand medullary sponge kidney

The Bosniak classification categorizes renal cysts into five groupsCategory I

Benign simple cyst with thin wall without septa calcifications or solid

components

It does not enhance with contrast and has a density equal to that of water

Category IIBenign cyst with a few thin septa which may contain fine calcifications or a

small

segment of mildly thickened calcification This includes homogenous

high-attenuation lesions less than 3 cm with sharp margins(Rich Kosak) but

without enhancement

Category IIFWell marginated cysts with a number of thin septa with or without mild

enhancement or thickening of septa Calcifications may be present these

may be thick and nodular There are no enhancing soft tissue components

This also includes nonenhancing high-attenuation lesions that are completely

contained within the kidney and are 3 cm or larger

Category IIIIndeterminate cystic masses with thickened irregular septa with enhancement

Category IVMalignant cystic masses with all the characteristics of category III lesions

but also with enhancing soft tissue components independent of but adjacent

to the septa

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 11)

Classic findings of a simple cyst(Bosniak category 111)

Classic findings of a simple cyst(Bosniak category 1V)

Para-pelvic cyst USamp CT images

US of polycystic kidney disease

Renal infection

US of acute pyelonephritis

Acute bacterial pyelonephritis (a) US scan shows a wedge-shaped hyperechoic focus (arrowhead) in the upper pole of the right kidney related to acute bacterial pyelonephritis (b) Color flow US image demonstrates diminished flow through the involved area

US and color Doppler images of right kidney shows focal hyperechoic nephritis with decreased perfusion at the Doppler US

US and color Doppler images of kidney shows two multifocal nephritis with decreased perfusion at the Doppler US

Masslike appearance of acute bacterial pyelonephritis US and CT images

Emphysematous pyelonephritis (a) US image shows nondependent echoes within the left kidney that demonstrate a ring-down artifact (b) Corresponding CT scan helps confirm that this pattern is caused by intraparenchymal air

Xanthogranulomatous pyelonephritis (a) Contrast-enhanced CT scan demonstrates bilateral staghorn calculi with distention of the right collecting system secondary to inflammatory debris (b) US scan also shows the dilated

collecting system (arrowheads) and a shadowing calculus (arrow)

Early and mature abscess cavities (a) US scan demonstrates a geographic hypoechoic focus from an abscess in the upper pole of the right kidney (b) On a US scan of a more mature abscess the cavity is better defined with a visible pseudocapsule and through transmission that is evidenced by increased echogenicity deep to the upper pole lesion

Pyohydronephrosis

Pyohydronephrosis

Renal hydatidosis is an insidious disease and patients

often present with nonspecific clinical signs or symptoms Presenting complaints are dull flank pain hematuria palpable flank mass hypertension and renal colic

Disseminated abdominal retroperitoneal and pelvic hydatid disease (a) The right kidney is pushed to the midline and the left kidney is hydronephrotic and shrunken by retroperitoneal hydatid cysts (b) Ultrasound of the abdomen showing cystic lesions in the retroperitoneum in the position of the kidneys

Hydatid disease of the kidney US and CT images

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 47: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Pelvic ectopic kidney

UltrasonographyOn sonograms stones are demonstrated as bright echogenic foci with posterior acoustic shadowing Stones are visualized fairly well with US in the kidneys and the distal ureter at or near the UVJ especially if dilatation is present US is good for the visualization of complications such as hydronephrosis (or other signs of obstruction) however some patients with acute obstruction have little or no dilationIn particular US is helpful in evaluating those with renal insufficiency or contraindications for the use of contrast media however US is often skipped in favor of nonenhanced CTIn addition US is good for characterizing lucent filling defects that are visualized as stones on IVU However US does not provide direct physiologic information regarding the degree of obstruction Doppler imaging may demonstrate a high resistive index in acute obstruction but this may not occur immediately or after forniceal rupture Absence of the ureteral jet as visualized with color Doppler on the symptomatic side is presumptive evidence for a high-grade obstruction in a well-hydrated patient

Degree of confidenceUS is very insensitive for stones especially stones smaller than 2 mm stones at the UPJ or stones in the mid ureter Fowler et al suggest that US has a sensitivity as low as 24 compared with nonenhanced CT Furthermore estimations of stone size may not be accurate Compared with nonenhanced CT US is more dependent on the operators ability and more time consuming

False positivesnegativesUS is fairly specific when stones are seen with a specificity as high as 90 With US matrix or indinavir stones may have soft tissue echogenicity without shadowing False-positive findings may result from renal vascular calcifications False-positive diagnoses of hydronephrosis also result from dilated vascular structures in the renal hilum Doppler imaging is helpful in distinguishing dilated vascular structures from hydronephrosis

Renal sonogram demonstrates an echogenic shadowing calculus in the renal collecting system with hydronephrosis

US images for renal stones

US images of staghorn stones

US images for ureteric stones

US images for nephrocalcinosis

Renal cystA renal cyst is a fluid collection in the kidney There are several types based on the Bosniak classification The majority are benign simple cysts that can be monitored and not intervened upon However some are cancerous or are suspicious for cancer and are commonly removed in a surgical procedure called nephrectomyNumerous renal cysts are seen in the cystic kidney diseases which include polycystic kidney diseaseand medullary sponge kidney

The Bosniak classification categorizes renal cysts into five groupsCategory I

Benign simple cyst with thin wall without septa calcifications or solid

components

It does not enhance with contrast and has a density equal to that of water

Category IIBenign cyst with a few thin septa which may contain fine calcifications or a

small

segment of mildly thickened calcification This includes homogenous

high-attenuation lesions less than 3 cm with sharp margins(Rich Kosak) but

without enhancement

Category IIFWell marginated cysts with a number of thin septa with or without mild

enhancement or thickening of septa Calcifications may be present these

may be thick and nodular There are no enhancing soft tissue components

This also includes nonenhancing high-attenuation lesions that are completely

contained within the kidney and are 3 cm or larger

Category IIIIndeterminate cystic masses with thickened irregular septa with enhancement

Category IVMalignant cystic masses with all the characteristics of category III lesions

but also with enhancing soft tissue components independent of but adjacent

to the septa

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 11)

Classic findings of a simple cyst(Bosniak category 111)

Classic findings of a simple cyst(Bosniak category 1V)

Para-pelvic cyst USamp CT images

US of polycystic kidney disease

Renal infection

US of acute pyelonephritis

Acute bacterial pyelonephritis (a) US scan shows a wedge-shaped hyperechoic focus (arrowhead) in the upper pole of the right kidney related to acute bacterial pyelonephritis (b) Color flow US image demonstrates diminished flow through the involved area

US and color Doppler images of right kidney shows focal hyperechoic nephritis with decreased perfusion at the Doppler US

US and color Doppler images of kidney shows two multifocal nephritis with decreased perfusion at the Doppler US

Masslike appearance of acute bacterial pyelonephritis US and CT images

Emphysematous pyelonephritis (a) US image shows nondependent echoes within the left kidney that demonstrate a ring-down artifact (b) Corresponding CT scan helps confirm that this pattern is caused by intraparenchymal air

Xanthogranulomatous pyelonephritis (a) Contrast-enhanced CT scan demonstrates bilateral staghorn calculi with distention of the right collecting system secondary to inflammatory debris (b) US scan also shows the dilated

collecting system (arrowheads) and a shadowing calculus (arrow)

Early and mature abscess cavities (a) US scan demonstrates a geographic hypoechoic focus from an abscess in the upper pole of the right kidney (b) On a US scan of a more mature abscess the cavity is better defined with a visible pseudocapsule and through transmission that is evidenced by increased echogenicity deep to the upper pole lesion

Pyohydronephrosis

Pyohydronephrosis

Renal hydatidosis is an insidious disease and patients

often present with nonspecific clinical signs or symptoms Presenting complaints are dull flank pain hematuria palpable flank mass hypertension and renal colic

Disseminated abdominal retroperitoneal and pelvic hydatid disease (a) The right kidney is pushed to the midline and the left kidney is hydronephrotic and shrunken by retroperitoneal hydatid cysts (b) Ultrasound of the abdomen showing cystic lesions in the retroperitoneum in the position of the kidneys

Hydatid disease of the kidney US and CT images

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 48: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

UltrasonographyOn sonograms stones are demonstrated as bright echogenic foci with posterior acoustic shadowing Stones are visualized fairly well with US in the kidneys and the distal ureter at or near the UVJ especially if dilatation is present US is good for the visualization of complications such as hydronephrosis (or other signs of obstruction) however some patients with acute obstruction have little or no dilationIn particular US is helpful in evaluating those with renal insufficiency or contraindications for the use of contrast media however US is often skipped in favor of nonenhanced CTIn addition US is good for characterizing lucent filling defects that are visualized as stones on IVU However US does not provide direct physiologic information regarding the degree of obstruction Doppler imaging may demonstrate a high resistive index in acute obstruction but this may not occur immediately or after forniceal rupture Absence of the ureteral jet as visualized with color Doppler on the symptomatic side is presumptive evidence for a high-grade obstruction in a well-hydrated patient

Degree of confidenceUS is very insensitive for stones especially stones smaller than 2 mm stones at the UPJ or stones in the mid ureter Fowler et al suggest that US has a sensitivity as low as 24 compared with nonenhanced CT Furthermore estimations of stone size may not be accurate Compared with nonenhanced CT US is more dependent on the operators ability and more time consuming

False positivesnegativesUS is fairly specific when stones are seen with a specificity as high as 90 With US matrix or indinavir stones may have soft tissue echogenicity without shadowing False-positive findings may result from renal vascular calcifications False-positive diagnoses of hydronephrosis also result from dilated vascular structures in the renal hilum Doppler imaging is helpful in distinguishing dilated vascular structures from hydronephrosis

Renal sonogram demonstrates an echogenic shadowing calculus in the renal collecting system with hydronephrosis

US images for renal stones

US images of staghorn stones

US images for ureteric stones

US images for nephrocalcinosis

Renal cystA renal cyst is a fluid collection in the kidney There are several types based on the Bosniak classification The majority are benign simple cysts that can be monitored and not intervened upon However some are cancerous or are suspicious for cancer and are commonly removed in a surgical procedure called nephrectomyNumerous renal cysts are seen in the cystic kidney diseases which include polycystic kidney diseaseand medullary sponge kidney

The Bosniak classification categorizes renal cysts into five groupsCategory I

Benign simple cyst with thin wall without septa calcifications or solid

components

It does not enhance with contrast and has a density equal to that of water

Category IIBenign cyst with a few thin septa which may contain fine calcifications or a

small

segment of mildly thickened calcification This includes homogenous

high-attenuation lesions less than 3 cm with sharp margins(Rich Kosak) but

without enhancement

Category IIFWell marginated cysts with a number of thin septa with or without mild

enhancement or thickening of septa Calcifications may be present these

may be thick and nodular There are no enhancing soft tissue components

This also includes nonenhancing high-attenuation lesions that are completely

contained within the kidney and are 3 cm or larger

Category IIIIndeterminate cystic masses with thickened irregular septa with enhancement

Category IVMalignant cystic masses with all the characteristics of category III lesions

but also with enhancing soft tissue components independent of but adjacent

to the septa

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 11)

Classic findings of a simple cyst(Bosniak category 111)

Classic findings of a simple cyst(Bosniak category 1V)

Para-pelvic cyst USamp CT images

US of polycystic kidney disease

Renal infection

US of acute pyelonephritis

Acute bacterial pyelonephritis (a) US scan shows a wedge-shaped hyperechoic focus (arrowhead) in the upper pole of the right kidney related to acute bacterial pyelonephritis (b) Color flow US image demonstrates diminished flow through the involved area

US and color Doppler images of right kidney shows focal hyperechoic nephritis with decreased perfusion at the Doppler US

US and color Doppler images of kidney shows two multifocal nephritis with decreased perfusion at the Doppler US

Masslike appearance of acute bacterial pyelonephritis US and CT images

Emphysematous pyelonephritis (a) US image shows nondependent echoes within the left kidney that demonstrate a ring-down artifact (b) Corresponding CT scan helps confirm that this pattern is caused by intraparenchymal air

Xanthogranulomatous pyelonephritis (a) Contrast-enhanced CT scan demonstrates bilateral staghorn calculi with distention of the right collecting system secondary to inflammatory debris (b) US scan also shows the dilated

collecting system (arrowheads) and a shadowing calculus (arrow)

Early and mature abscess cavities (a) US scan demonstrates a geographic hypoechoic focus from an abscess in the upper pole of the right kidney (b) On a US scan of a more mature abscess the cavity is better defined with a visible pseudocapsule and through transmission that is evidenced by increased echogenicity deep to the upper pole lesion

Pyohydronephrosis

Pyohydronephrosis

Renal hydatidosis is an insidious disease and patients

often present with nonspecific clinical signs or symptoms Presenting complaints are dull flank pain hematuria palpable flank mass hypertension and renal colic

Disseminated abdominal retroperitoneal and pelvic hydatid disease (a) The right kidney is pushed to the midline and the left kidney is hydronephrotic and shrunken by retroperitoneal hydatid cysts (b) Ultrasound of the abdomen showing cystic lesions in the retroperitoneum in the position of the kidneys

Hydatid disease of the kidney US and CT images

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 49: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Degree of confidenceUS is very insensitive for stones especially stones smaller than 2 mm stones at the UPJ or stones in the mid ureter Fowler et al suggest that US has a sensitivity as low as 24 compared with nonenhanced CT Furthermore estimations of stone size may not be accurate Compared with nonenhanced CT US is more dependent on the operators ability and more time consuming

False positivesnegativesUS is fairly specific when stones are seen with a specificity as high as 90 With US matrix or indinavir stones may have soft tissue echogenicity without shadowing False-positive findings may result from renal vascular calcifications False-positive diagnoses of hydronephrosis also result from dilated vascular structures in the renal hilum Doppler imaging is helpful in distinguishing dilated vascular structures from hydronephrosis

Renal sonogram demonstrates an echogenic shadowing calculus in the renal collecting system with hydronephrosis

US images for renal stones

US images of staghorn stones

US images for ureteric stones

US images for nephrocalcinosis

Renal cystA renal cyst is a fluid collection in the kidney There are several types based on the Bosniak classification The majority are benign simple cysts that can be monitored and not intervened upon However some are cancerous or are suspicious for cancer and are commonly removed in a surgical procedure called nephrectomyNumerous renal cysts are seen in the cystic kidney diseases which include polycystic kidney diseaseand medullary sponge kidney

The Bosniak classification categorizes renal cysts into five groupsCategory I

Benign simple cyst with thin wall without septa calcifications or solid

components

It does not enhance with contrast and has a density equal to that of water

Category IIBenign cyst with a few thin septa which may contain fine calcifications or a

small

segment of mildly thickened calcification This includes homogenous

high-attenuation lesions less than 3 cm with sharp margins(Rich Kosak) but

without enhancement

Category IIFWell marginated cysts with a number of thin septa with or without mild

enhancement or thickening of septa Calcifications may be present these

may be thick and nodular There are no enhancing soft tissue components

This also includes nonenhancing high-attenuation lesions that are completely

contained within the kidney and are 3 cm or larger

Category IIIIndeterminate cystic masses with thickened irregular septa with enhancement

Category IVMalignant cystic masses with all the characteristics of category III lesions

but also with enhancing soft tissue components independent of but adjacent

to the septa

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 11)

Classic findings of a simple cyst(Bosniak category 111)

Classic findings of a simple cyst(Bosniak category 1V)

Para-pelvic cyst USamp CT images

US of polycystic kidney disease

Renal infection

US of acute pyelonephritis

Acute bacterial pyelonephritis (a) US scan shows a wedge-shaped hyperechoic focus (arrowhead) in the upper pole of the right kidney related to acute bacterial pyelonephritis (b) Color flow US image demonstrates diminished flow through the involved area

US and color Doppler images of right kidney shows focal hyperechoic nephritis with decreased perfusion at the Doppler US

US and color Doppler images of kidney shows two multifocal nephritis with decreased perfusion at the Doppler US

Masslike appearance of acute bacterial pyelonephritis US and CT images

Emphysematous pyelonephritis (a) US image shows nondependent echoes within the left kidney that demonstrate a ring-down artifact (b) Corresponding CT scan helps confirm that this pattern is caused by intraparenchymal air

Xanthogranulomatous pyelonephritis (a) Contrast-enhanced CT scan demonstrates bilateral staghorn calculi with distention of the right collecting system secondary to inflammatory debris (b) US scan also shows the dilated

collecting system (arrowheads) and a shadowing calculus (arrow)

Early and mature abscess cavities (a) US scan demonstrates a geographic hypoechoic focus from an abscess in the upper pole of the right kidney (b) On a US scan of a more mature abscess the cavity is better defined with a visible pseudocapsule and through transmission that is evidenced by increased echogenicity deep to the upper pole lesion

Pyohydronephrosis

Pyohydronephrosis

Renal hydatidosis is an insidious disease and patients

often present with nonspecific clinical signs or symptoms Presenting complaints are dull flank pain hematuria palpable flank mass hypertension and renal colic

Disseminated abdominal retroperitoneal and pelvic hydatid disease (a) The right kidney is pushed to the midline and the left kidney is hydronephrotic and shrunken by retroperitoneal hydatid cysts (b) Ultrasound of the abdomen showing cystic lesions in the retroperitoneum in the position of the kidneys

Hydatid disease of the kidney US and CT images

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 50: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Renal sonogram demonstrates an echogenic shadowing calculus in the renal collecting system with hydronephrosis

US images for renal stones

US images of staghorn stones

US images for ureteric stones

US images for nephrocalcinosis

Renal cystA renal cyst is a fluid collection in the kidney There are several types based on the Bosniak classification The majority are benign simple cysts that can be monitored and not intervened upon However some are cancerous or are suspicious for cancer and are commonly removed in a surgical procedure called nephrectomyNumerous renal cysts are seen in the cystic kidney diseases which include polycystic kidney diseaseand medullary sponge kidney

The Bosniak classification categorizes renal cysts into five groupsCategory I

Benign simple cyst with thin wall without septa calcifications or solid

components

It does not enhance with contrast and has a density equal to that of water

Category IIBenign cyst with a few thin septa which may contain fine calcifications or a

small

segment of mildly thickened calcification This includes homogenous

high-attenuation lesions less than 3 cm with sharp margins(Rich Kosak) but

without enhancement

Category IIFWell marginated cysts with a number of thin septa with or without mild

enhancement or thickening of septa Calcifications may be present these

may be thick and nodular There are no enhancing soft tissue components

This also includes nonenhancing high-attenuation lesions that are completely

contained within the kidney and are 3 cm or larger

Category IIIIndeterminate cystic masses with thickened irregular septa with enhancement

Category IVMalignant cystic masses with all the characteristics of category III lesions

but also with enhancing soft tissue components independent of but adjacent

to the septa

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 11)

Classic findings of a simple cyst(Bosniak category 111)

Classic findings of a simple cyst(Bosniak category 1V)

Para-pelvic cyst USamp CT images

US of polycystic kidney disease

Renal infection

US of acute pyelonephritis

Acute bacterial pyelonephritis (a) US scan shows a wedge-shaped hyperechoic focus (arrowhead) in the upper pole of the right kidney related to acute bacterial pyelonephritis (b) Color flow US image demonstrates diminished flow through the involved area

US and color Doppler images of right kidney shows focal hyperechoic nephritis with decreased perfusion at the Doppler US

US and color Doppler images of kidney shows two multifocal nephritis with decreased perfusion at the Doppler US

Masslike appearance of acute bacterial pyelonephritis US and CT images

Emphysematous pyelonephritis (a) US image shows nondependent echoes within the left kidney that demonstrate a ring-down artifact (b) Corresponding CT scan helps confirm that this pattern is caused by intraparenchymal air

Xanthogranulomatous pyelonephritis (a) Contrast-enhanced CT scan demonstrates bilateral staghorn calculi with distention of the right collecting system secondary to inflammatory debris (b) US scan also shows the dilated

collecting system (arrowheads) and a shadowing calculus (arrow)

Early and mature abscess cavities (a) US scan demonstrates a geographic hypoechoic focus from an abscess in the upper pole of the right kidney (b) On a US scan of a more mature abscess the cavity is better defined with a visible pseudocapsule and through transmission that is evidenced by increased echogenicity deep to the upper pole lesion

Pyohydronephrosis

Pyohydronephrosis

Renal hydatidosis is an insidious disease and patients

often present with nonspecific clinical signs or symptoms Presenting complaints are dull flank pain hematuria palpable flank mass hypertension and renal colic

Disseminated abdominal retroperitoneal and pelvic hydatid disease (a) The right kidney is pushed to the midline and the left kidney is hydronephrotic and shrunken by retroperitoneal hydatid cysts (b) Ultrasound of the abdomen showing cystic lesions in the retroperitoneum in the position of the kidneys

Hydatid disease of the kidney US and CT images

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 51: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

US images for renal stones

US images of staghorn stones

US images for ureteric stones

US images for nephrocalcinosis

Renal cystA renal cyst is a fluid collection in the kidney There are several types based on the Bosniak classification The majority are benign simple cysts that can be monitored and not intervened upon However some are cancerous or are suspicious for cancer and are commonly removed in a surgical procedure called nephrectomyNumerous renal cysts are seen in the cystic kidney diseases which include polycystic kidney diseaseand medullary sponge kidney

The Bosniak classification categorizes renal cysts into five groupsCategory I

Benign simple cyst with thin wall without septa calcifications or solid

components

It does not enhance with contrast and has a density equal to that of water

Category IIBenign cyst with a few thin septa which may contain fine calcifications or a

small

segment of mildly thickened calcification This includes homogenous

high-attenuation lesions less than 3 cm with sharp margins(Rich Kosak) but

without enhancement

Category IIFWell marginated cysts with a number of thin septa with or without mild

enhancement or thickening of septa Calcifications may be present these

may be thick and nodular There are no enhancing soft tissue components

This also includes nonenhancing high-attenuation lesions that are completely

contained within the kidney and are 3 cm or larger

Category IIIIndeterminate cystic masses with thickened irregular septa with enhancement

Category IVMalignant cystic masses with all the characteristics of category III lesions

but also with enhancing soft tissue components independent of but adjacent

to the septa

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 11)

Classic findings of a simple cyst(Bosniak category 111)

Classic findings of a simple cyst(Bosniak category 1V)

Para-pelvic cyst USamp CT images

US of polycystic kidney disease

Renal infection

US of acute pyelonephritis

Acute bacterial pyelonephritis (a) US scan shows a wedge-shaped hyperechoic focus (arrowhead) in the upper pole of the right kidney related to acute bacterial pyelonephritis (b) Color flow US image demonstrates diminished flow through the involved area

US and color Doppler images of right kidney shows focal hyperechoic nephritis with decreased perfusion at the Doppler US

US and color Doppler images of kidney shows two multifocal nephritis with decreased perfusion at the Doppler US

Masslike appearance of acute bacterial pyelonephritis US and CT images

Emphysematous pyelonephritis (a) US image shows nondependent echoes within the left kidney that demonstrate a ring-down artifact (b) Corresponding CT scan helps confirm that this pattern is caused by intraparenchymal air

Xanthogranulomatous pyelonephritis (a) Contrast-enhanced CT scan demonstrates bilateral staghorn calculi with distention of the right collecting system secondary to inflammatory debris (b) US scan also shows the dilated

collecting system (arrowheads) and a shadowing calculus (arrow)

Early and mature abscess cavities (a) US scan demonstrates a geographic hypoechoic focus from an abscess in the upper pole of the right kidney (b) On a US scan of a more mature abscess the cavity is better defined with a visible pseudocapsule and through transmission that is evidenced by increased echogenicity deep to the upper pole lesion

Pyohydronephrosis

Pyohydronephrosis

Renal hydatidosis is an insidious disease and patients

often present with nonspecific clinical signs or symptoms Presenting complaints are dull flank pain hematuria palpable flank mass hypertension and renal colic

Disseminated abdominal retroperitoneal and pelvic hydatid disease (a) The right kidney is pushed to the midline and the left kidney is hydronephrotic and shrunken by retroperitoneal hydatid cysts (b) Ultrasound of the abdomen showing cystic lesions in the retroperitoneum in the position of the kidneys

Hydatid disease of the kidney US and CT images

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 52: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

US images of staghorn stones

US images for ureteric stones

US images for nephrocalcinosis

Renal cystA renal cyst is a fluid collection in the kidney There are several types based on the Bosniak classification The majority are benign simple cysts that can be monitored and not intervened upon However some are cancerous or are suspicious for cancer and are commonly removed in a surgical procedure called nephrectomyNumerous renal cysts are seen in the cystic kidney diseases which include polycystic kidney diseaseand medullary sponge kidney

The Bosniak classification categorizes renal cysts into five groupsCategory I

Benign simple cyst with thin wall without septa calcifications or solid

components

It does not enhance with contrast and has a density equal to that of water

Category IIBenign cyst with a few thin septa which may contain fine calcifications or a

small

segment of mildly thickened calcification This includes homogenous

high-attenuation lesions less than 3 cm with sharp margins(Rich Kosak) but

without enhancement

Category IIFWell marginated cysts with a number of thin septa with or without mild

enhancement or thickening of septa Calcifications may be present these

may be thick and nodular There are no enhancing soft tissue components

This also includes nonenhancing high-attenuation lesions that are completely

contained within the kidney and are 3 cm or larger

Category IIIIndeterminate cystic masses with thickened irregular septa with enhancement

Category IVMalignant cystic masses with all the characteristics of category III lesions

but also with enhancing soft tissue components independent of but adjacent

to the septa

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 11)

Classic findings of a simple cyst(Bosniak category 111)

Classic findings of a simple cyst(Bosniak category 1V)

Para-pelvic cyst USamp CT images

US of polycystic kidney disease

Renal infection

US of acute pyelonephritis

Acute bacterial pyelonephritis (a) US scan shows a wedge-shaped hyperechoic focus (arrowhead) in the upper pole of the right kidney related to acute bacterial pyelonephritis (b) Color flow US image demonstrates diminished flow through the involved area

US and color Doppler images of right kidney shows focal hyperechoic nephritis with decreased perfusion at the Doppler US

US and color Doppler images of kidney shows two multifocal nephritis with decreased perfusion at the Doppler US

Masslike appearance of acute bacterial pyelonephritis US and CT images

Emphysematous pyelonephritis (a) US image shows nondependent echoes within the left kidney that demonstrate a ring-down artifact (b) Corresponding CT scan helps confirm that this pattern is caused by intraparenchymal air

Xanthogranulomatous pyelonephritis (a) Contrast-enhanced CT scan demonstrates bilateral staghorn calculi with distention of the right collecting system secondary to inflammatory debris (b) US scan also shows the dilated

collecting system (arrowheads) and a shadowing calculus (arrow)

Early and mature abscess cavities (a) US scan demonstrates a geographic hypoechoic focus from an abscess in the upper pole of the right kidney (b) On a US scan of a more mature abscess the cavity is better defined with a visible pseudocapsule and through transmission that is evidenced by increased echogenicity deep to the upper pole lesion

Pyohydronephrosis

Pyohydronephrosis

Renal hydatidosis is an insidious disease and patients

often present with nonspecific clinical signs or symptoms Presenting complaints are dull flank pain hematuria palpable flank mass hypertension and renal colic

Disseminated abdominal retroperitoneal and pelvic hydatid disease (a) The right kidney is pushed to the midline and the left kidney is hydronephrotic and shrunken by retroperitoneal hydatid cysts (b) Ultrasound of the abdomen showing cystic lesions in the retroperitoneum in the position of the kidneys

Hydatid disease of the kidney US and CT images

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 53: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

US images for ureteric stones

US images for nephrocalcinosis

Renal cystA renal cyst is a fluid collection in the kidney There are several types based on the Bosniak classification The majority are benign simple cysts that can be monitored and not intervened upon However some are cancerous or are suspicious for cancer and are commonly removed in a surgical procedure called nephrectomyNumerous renal cysts are seen in the cystic kidney diseases which include polycystic kidney diseaseand medullary sponge kidney

The Bosniak classification categorizes renal cysts into five groupsCategory I

Benign simple cyst with thin wall without septa calcifications or solid

components

It does not enhance with contrast and has a density equal to that of water

Category IIBenign cyst with a few thin septa which may contain fine calcifications or a

small

segment of mildly thickened calcification This includes homogenous

high-attenuation lesions less than 3 cm with sharp margins(Rich Kosak) but

without enhancement

Category IIFWell marginated cysts with a number of thin septa with or without mild

enhancement or thickening of septa Calcifications may be present these

may be thick and nodular There are no enhancing soft tissue components

This also includes nonenhancing high-attenuation lesions that are completely

contained within the kidney and are 3 cm or larger

Category IIIIndeterminate cystic masses with thickened irregular septa with enhancement

Category IVMalignant cystic masses with all the characteristics of category III lesions

but also with enhancing soft tissue components independent of but adjacent

to the septa

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 11)

Classic findings of a simple cyst(Bosniak category 111)

Classic findings of a simple cyst(Bosniak category 1V)

Para-pelvic cyst USamp CT images

US of polycystic kidney disease

Renal infection

US of acute pyelonephritis

Acute bacterial pyelonephritis (a) US scan shows a wedge-shaped hyperechoic focus (arrowhead) in the upper pole of the right kidney related to acute bacterial pyelonephritis (b) Color flow US image demonstrates diminished flow through the involved area

US and color Doppler images of right kidney shows focal hyperechoic nephritis with decreased perfusion at the Doppler US

US and color Doppler images of kidney shows two multifocal nephritis with decreased perfusion at the Doppler US

Masslike appearance of acute bacterial pyelonephritis US and CT images

Emphysematous pyelonephritis (a) US image shows nondependent echoes within the left kidney that demonstrate a ring-down artifact (b) Corresponding CT scan helps confirm that this pattern is caused by intraparenchymal air

Xanthogranulomatous pyelonephritis (a) Contrast-enhanced CT scan demonstrates bilateral staghorn calculi with distention of the right collecting system secondary to inflammatory debris (b) US scan also shows the dilated

collecting system (arrowheads) and a shadowing calculus (arrow)

Early and mature abscess cavities (a) US scan demonstrates a geographic hypoechoic focus from an abscess in the upper pole of the right kidney (b) On a US scan of a more mature abscess the cavity is better defined with a visible pseudocapsule and through transmission that is evidenced by increased echogenicity deep to the upper pole lesion

Pyohydronephrosis

Pyohydronephrosis

Renal hydatidosis is an insidious disease and patients

often present with nonspecific clinical signs or symptoms Presenting complaints are dull flank pain hematuria palpable flank mass hypertension and renal colic

Disseminated abdominal retroperitoneal and pelvic hydatid disease (a) The right kidney is pushed to the midline and the left kidney is hydronephrotic and shrunken by retroperitoneal hydatid cysts (b) Ultrasound of the abdomen showing cystic lesions in the retroperitoneum in the position of the kidneys

Hydatid disease of the kidney US and CT images

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 54: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

US images for nephrocalcinosis

Renal cystA renal cyst is a fluid collection in the kidney There are several types based on the Bosniak classification The majority are benign simple cysts that can be monitored and not intervened upon However some are cancerous or are suspicious for cancer and are commonly removed in a surgical procedure called nephrectomyNumerous renal cysts are seen in the cystic kidney diseases which include polycystic kidney diseaseand medullary sponge kidney

The Bosniak classification categorizes renal cysts into five groupsCategory I

Benign simple cyst with thin wall without septa calcifications or solid

components

It does not enhance with contrast and has a density equal to that of water

Category IIBenign cyst with a few thin septa which may contain fine calcifications or a

small

segment of mildly thickened calcification This includes homogenous

high-attenuation lesions less than 3 cm with sharp margins(Rich Kosak) but

without enhancement

Category IIFWell marginated cysts with a number of thin septa with or without mild

enhancement or thickening of septa Calcifications may be present these

may be thick and nodular There are no enhancing soft tissue components

This also includes nonenhancing high-attenuation lesions that are completely

contained within the kidney and are 3 cm or larger

Category IIIIndeterminate cystic masses with thickened irregular septa with enhancement

Category IVMalignant cystic masses with all the characteristics of category III lesions

but also with enhancing soft tissue components independent of but adjacent

to the septa

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 11)

Classic findings of a simple cyst(Bosniak category 111)

Classic findings of a simple cyst(Bosniak category 1V)

Para-pelvic cyst USamp CT images

US of polycystic kidney disease

Renal infection

US of acute pyelonephritis

Acute bacterial pyelonephritis (a) US scan shows a wedge-shaped hyperechoic focus (arrowhead) in the upper pole of the right kidney related to acute bacterial pyelonephritis (b) Color flow US image demonstrates diminished flow through the involved area

US and color Doppler images of right kidney shows focal hyperechoic nephritis with decreased perfusion at the Doppler US

US and color Doppler images of kidney shows two multifocal nephritis with decreased perfusion at the Doppler US

Masslike appearance of acute bacterial pyelonephritis US and CT images

Emphysematous pyelonephritis (a) US image shows nondependent echoes within the left kidney that demonstrate a ring-down artifact (b) Corresponding CT scan helps confirm that this pattern is caused by intraparenchymal air

Xanthogranulomatous pyelonephritis (a) Contrast-enhanced CT scan demonstrates bilateral staghorn calculi with distention of the right collecting system secondary to inflammatory debris (b) US scan also shows the dilated

collecting system (arrowheads) and a shadowing calculus (arrow)

Early and mature abscess cavities (a) US scan demonstrates a geographic hypoechoic focus from an abscess in the upper pole of the right kidney (b) On a US scan of a more mature abscess the cavity is better defined with a visible pseudocapsule and through transmission that is evidenced by increased echogenicity deep to the upper pole lesion

Pyohydronephrosis

Pyohydronephrosis

Renal hydatidosis is an insidious disease and patients

often present with nonspecific clinical signs or symptoms Presenting complaints are dull flank pain hematuria palpable flank mass hypertension and renal colic

Disseminated abdominal retroperitoneal and pelvic hydatid disease (a) The right kidney is pushed to the midline and the left kidney is hydronephrotic and shrunken by retroperitoneal hydatid cysts (b) Ultrasound of the abdomen showing cystic lesions in the retroperitoneum in the position of the kidneys

Hydatid disease of the kidney US and CT images

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 55: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Renal cystA renal cyst is a fluid collection in the kidney There are several types based on the Bosniak classification The majority are benign simple cysts that can be monitored and not intervened upon However some are cancerous or are suspicious for cancer and are commonly removed in a surgical procedure called nephrectomyNumerous renal cysts are seen in the cystic kidney diseases which include polycystic kidney diseaseand medullary sponge kidney

The Bosniak classification categorizes renal cysts into five groupsCategory I

Benign simple cyst with thin wall without septa calcifications or solid

components

It does not enhance with contrast and has a density equal to that of water

Category IIBenign cyst with a few thin septa which may contain fine calcifications or a

small

segment of mildly thickened calcification This includes homogenous

high-attenuation lesions less than 3 cm with sharp margins(Rich Kosak) but

without enhancement

Category IIFWell marginated cysts with a number of thin septa with or without mild

enhancement or thickening of septa Calcifications may be present these

may be thick and nodular There are no enhancing soft tissue components

This also includes nonenhancing high-attenuation lesions that are completely

contained within the kidney and are 3 cm or larger

Category IIIIndeterminate cystic masses with thickened irregular septa with enhancement

Category IVMalignant cystic masses with all the characteristics of category III lesions

but also with enhancing soft tissue components independent of but adjacent

to the septa

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 11)

Classic findings of a simple cyst(Bosniak category 111)

Classic findings of a simple cyst(Bosniak category 1V)

Para-pelvic cyst USamp CT images

US of polycystic kidney disease

Renal infection

US of acute pyelonephritis

Acute bacterial pyelonephritis (a) US scan shows a wedge-shaped hyperechoic focus (arrowhead) in the upper pole of the right kidney related to acute bacterial pyelonephritis (b) Color flow US image demonstrates diminished flow through the involved area

US and color Doppler images of right kidney shows focal hyperechoic nephritis with decreased perfusion at the Doppler US

US and color Doppler images of kidney shows two multifocal nephritis with decreased perfusion at the Doppler US

Masslike appearance of acute bacterial pyelonephritis US and CT images

Emphysematous pyelonephritis (a) US image shows nondependent echoes within the left kidney that demonstrate a ring-down artifact (b) Corresponding CT scan helps confirm that this pattern is caused by intraparenchymal air

Xanthogranulomatous pyelonephritis (a) Contrast-enhanced CT scan demonstrates bilateral staghorn calculi with distention of the right collecting system secondary to inflammatory debris (b) US scan also shows the dilated

collecting system (arrowheads) and a shadowing calculus (arrow)

Early and mature abscess cavities (a) US scan demonstrates a geographic hypoechoic focus from an abscess in the upper pole of the right kidney (b) On a US scan of a more mature abscess the cavity is better defined with a visible pseudocapsule and through transmission that is evidenced by increased echogenicity deep to the upper pole lesion

Pyohydronephrosis

Pyohydronephrosis

Renal hydatidosis is an insidious disease and patients

often present with nonspecific clinical signs or symptoms Presenting complaints are dull flank pain hematuria palpable flank mass hypertension and renal colic

Disseminated abdominal retroperitoneal and pelvic hydatid disease (a) The right kidney is pushed to the midline and the left kidney is hydronephrotic and shrunken by retroperitoneal hydatid cysts (b) Ultrasound of the abdomen showing cystic lesions in the retroperitoneum in the position of the kidneys

Hydatid disease of the kidney US and CT images

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 56: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

The Bosniak classification categorizes renal cysts into five groupsCategory I

Benign simple cyst with thin wall without septa calcifications or solid

components

It does not enhance with contrast and has a density equal to that of water

Category IIBenign cyst with a few thin septa which may contain fine calcifications or a

small

segment of mildly thickened calcification This includes homogenous

high-attenuation lesions less than 3 cm with sharp margins(Rich Kosak) but

without enhancement

Category IIFWell marginated cysts with a number of thin septa with or without mild

enhancement or thickening of septa Calcifications may be present these

may be thick and nodular There are no enhancing soft tissue components

This also includes nonenhancing high-attenuation lesions that are completely

contained within the kidney and are 3 cm or larger

Category IIIIndeterminate cystic masses with thickened irregular septa with enhancement

Category IVMalignant cystic masses with all the characteristics of category III lesions

but also with enhancing soft tissue components independent of but adjacent

to the septa

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 11)

Classic findings of a simple cyst(Bosniak category 111)

Classic findings of a simple cyst(Bosniak category 1V)

Para-pelvic cyst USamp CT images

US of polycystic kidney disease

Renal infection

US of acute pyelonephritis

Acute bacterial pyelonephritis (a) US scan shows a wedge-shaped hyperechoic focus (arrowhead) in the upper pole of the right kidney related to acute bacterial pyelonephritis (b) Color flow US image demonstrates diminished flow through the involved area

US and color Doppler images of right kidney shows focal hyperechoic nephritis with decreased perfusion at the Doppler US

US and color Doppler images of kidney shows two multifocal nephritis with decreased perfusion at the Doppler US

Masslike appearance of acute bacterial pyelonephritis US and CT images

Emphysematous pyelonephritis (a) US image shows nondependent echoes within the left kidney that demonstrate a ring-down artifact (b) Corresponding CT scan helps confirm that this pattern is caused by intraparenchymal air

Xanthogranulomatous pyelonephritis (a) Contrast-enhanced CT scan demonstrates bilateral staghorn calculi with distention of the right collecting system secondary to inflammatory debris (b) US scan also shows the dilated

collecting system (arrowheads) and a shadowing calculus (arrow)

Early and mature abscess cavities (a) US scan demonstrates a geographic hypoechoic focus from an abscess in the upper pole of the right kidney (b) On a US scan of a more mature abscess the cavity is better defined with a visible pseudocapsule and through transmission that is evidenced by increased echogenicity deep to the upper pole lesion

Pyohydronephrosis

Pyohydronephrosis

Renal hydatidosis is an insidious disease and patients

often present with nonspecific clinical signs or symptoms Presenting complaints are dull flank pain hematuria palpable flank mass hypertension and renal colic

Disseminated abdominal retroperitoneal and pelvic hydatid disease (a) The right kidney is pushed to the midline and the left kidney is hydronephrotic and shrunken by retroperitoneal hydatid cysts (b) Ultrasound of the abdomen showing cystic lesions in the retroperitoneum in the position of the kidneys

Hydatid disease of the kidney US and CT images

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 57: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 11)

Classic findings of a simple cyst(Bosniak category 111)

Classic findings of a simple cyst(Bosniak category 1V)

Para-pelvic cyst USamp CT images

US of polycystic kidney disease

Renal infection

US of acute pyelonephritis

Acute bacterial pyelonephritis (a) US scan shows a wedge-shaped hyperechoic focus (arrowhead) in the upper pole of the right kidney related to acute bacterial pyelonephritis (b) Color flow US image demonstrates diminished flow through the involved area

US and color Doppler images of right kidney shows focal hyperechoic nephritis with decreased perfusion at the Doppler US

US and color Doppler images of kidney shows two multifocal nephritis with decreased perfusion at the Doppler US

Masslike appearance of acute bacterial pyelonephritis US and CT images

Emphysematous pyelonephritis (a) US image shows nondependent echoes within the left kidney that demonstrate a ring-down artifact (b) Corresponding CT scan helps confirm that this pattern is caused by intraparenchymal air

Xanthogranulomatous pyelonephritis (a) Contrast-enhanced CT scan demonstrates bilateral staghorn calculi with distention of the right collecting system secondary to inflammatory debris (b) US scan also shows the dilated

collecting system (arrowheads) and a shadowing calculus (arrow)

Early and mature abscess cavities (a) US scan demonstrates a geographic hypoechoic focus from an abscess in the upper pole of the right kidney (b) On a US scan of a more mature abscess the cavity is better defined with a visible pseudocapsule and through transmission that is evidenced by increased echogenicity deep to the upper pole lesion

Pyohydronephrosis

Pyohydronephrosis

Renal hydatidosis is an insidious disease and patients

often present with nonspecific clinical signs or symptoms Presenting complaints are dull flank pain hematuria palpable flank mass hypertension and renal colic

Disseminated abdominal retroperitoneal and pelvic hydatid disease (a) The right kidney is pushed to the midline and the left kidney is hydronephrotic and shrunken by retroperitoneal hydatid cysts (b) Ultrasound of the abdomen showing cystic lesions in the retroperitoneum in the position of the kidneys

Hydatid disease of the kidney US and CT images

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 58: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Classic findings of a simple cyst(Bosniak category 1)

Classic findings of a simple cyst(Bosniak category 11)

Classic findings of a simple cyst(Bosniak category 111)

Classic findings of a simple cyst(Bosniak category 1V)

Para-pelvic cyst USamp CT images

US of polycystic kidney disease

Renal infection

US of acute pyelonephritis

Acute bacterial pyelonephritis (a) US scan shows a wedge-shaped hyperechoic focus (arrowhead) in the upper pole of the right kidney related to acute bacterial pyelonephritis (b) Color flow US image demonstrates diminished flow through the involved area

US and color Doppler images of right kidney shows focal hyperechoic nephritis with decreased perfusion at the Doppler US

US and color Doppler images of kidney shows two multifocal nephritis with decreased perfusion at the Doppler US

Masslike appearance of acute bacterial pyelonephritis US and CT images

Emphysematous pyelonephritis (a) US image shows nondependent echoes within the left kidney that demonstrate a ring-down artifact (b) Corresponding CT scan helps confirm that this pattern is caused by intraparenchymal air

Xanthogranulomatous pyelonephritis (a) Contrast-enhanced CT scan demonstrates bilateral staghorn calculi with distention of the right collecting system secondary to inflammatory debris (b) US scan also shows the dilated

collecting system (arrowheads) and a shadowing calculus (arrow)

Early and mature abscess cavities (a) US scan demonstrates a geographic hypoechoic focus from an abscess in the upper pole of the right kidney (b) On a US scan of a more mature abscess the cavity is better defined with a visible pseudocapsule and through transmission that is evidenced by increased echogenicity deep to the upper pole lesion

Pyohydronephrosis

Pyohydronephrosis

Renal hydatidosis is an insidious disease and patients

often present with nonspecific clinical signs or symptoms Presenting complaints are dull flank pain hematuria palpable flank mass hypertension and renal colic

Disseminated abdominal retroperitoneal and pelvic hydatid disease (a) The right kidney is pushed to the midline and the left kidney is hydronephrotic and shrunken by retroperitoneal hydatid cysts (b) Ultrasound of the abdomen showing cystic lesions in the retroperitoneum in the position of the kidneys

Hydatid disease of the kidney US and CT images

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 59: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Classic findings of a simple cyst(Bosniak category 11)

Classic findings of a simple cyst(Bosniak category 111)

Classic findings of a simple cyst(Bosniak category 1V)

Para-pelvic cyst USamp CT images

US of polycystic kidney disease

Renal infection

US of acute pyelonephritis

Acute bacterial pyelonephritis (a) US scan shows a wedge-shaped hyperechoic focus (arrowhead) in the upper pole of the right kidney related to acute bacterial pyelonephritis (b) Color flow US image demonstrates diminished flow through the involved area

US and color Doppler images of right kidney shows focal hyperechoic nephritis with decreased perfusion at the Doppler US

US and color Doppler images of kidney shows two multifocal nephritis with decreased perfusion at the Doppler US

Masslike appearance of acute bacterial pyelonephritis US and CT images

Emphysematous pyelonephritis (a) US image shows nondependent echoes within the left kidney that demonstrate a ring-down artifact (b) Corresponding CT scan helps confirm that this pattern is caused by intraparenchymal air

Xanthogranulomatous pyelonephritis (a) Contrast-enhanced CT scan demonstrates bilateral staghorn calculi with distention of the right collecting system secondary to inflammatory debris (b) US scan also shows the dilated

collecting system (arrowheads) and a shadowing calculus (arrow)

Early and mature abscess cavities (a) US scan demonstrates a geographic hypoechoic focus from an abscess in the upper pole of the right kidney (b) On a US scan of a more mature abscess the cavity is better defined with a visible pseudocapsule and through transmission that is evidenced by increased echogenicity deep to the upper pole lesion

Pyohydronephrosis

Pyohydronephrosis

Renal hydatidosis is an insidious disease and patients

often present with nonspecific clinical signs or symptoms Presenting complaints are dull flank pain hematuria palpable flank mass hypertension and renal colic

Disseminated abdominal retroperitoneal and pelvic hydatid disease (a) The right kidney is pushed to the midline and the left kidney is hydronephrotic and shrunken by retroperitoneal hydatid cysts (b) Ultrasound of the abdomen showing cystic lesions in the retroperitoneum in the position of the kidneys

Hydatid disease of the kidney US and CT images

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 60: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Classic findings of a simple cyst(Bosniak category 111)

Classic findings of a simple cyst(Bosniak category 1V)

Para-pelvic cyst USamp CT images

US of polycystic kidney disease

Renal infection

US of acute pyelonephritis

Acute bacterial pyelonephritis (a) US scan shows a wedge-shaped hyperechoic focus (arrowhead) in the upper pole of the right kidney related to acute bacterial pyelonephritis (b) Color flow US image demonstrates diminished flow through the involved area

US and color Doppler images of right kidney shows focal hyperechoic nephritis with decreased perfusion at the Doppler US

US and color Doppler images of kidney shows two multifocal nephritis with decreased perfusion at the Doppler US

Masslike appearance of acute bacterial pyelonephritis US and CT images

Emphysematous pyelonephritis (a) US image shows nondependent echoes within the left kidney that demonstrate a ring-down artifact (b) Corresponding CT scan helps confirm that this pattern is caused by intraparenchymal air

Xanthogranulomatous pyelonephritis (a) Contrast-enhanced CT scan demonstrates bilateral staghorn calculi with distention of the right collecting system secondary to inflammatory debris (b) US scan also shows the dilated

collecting system (arrowheads) and a shadowing calculus (arrow)

Early and mature abscess cavities (a) US scan demonstrates a geographic hypoechoic focus from an abscess in the upper pole of the right kidney (b) On a US scan of a more mature abscess the cavity is better defined with a visible pseudocapsule and through transmission that is evidenced by increased echogenicity deep to the upper pole lesion

Pyohydronephrosis

Pyohydronephrosis

Renal hydatidosis is an insidious disease and patients

often present with nonspecific clinical signs or symptoms Presenting complaints are dull flank pain hematuria palpable flank mass hypertension and renal colic

Disseminated abdominal retroperitoneal and pelvic hydatid disease (a) The right kidney is pushed to the midline and the left kidney is hydronephrotic and shrunken by retroperitoneal hydatid cysts (b) Ultrasound of the abdomen showing cystic lesions in the retroperitoneum in the position of the kidneys

Hydatid disease of the kidney US and CT images

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 61: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Classic findings of a simple cyst(Bosniak category 1V)

Para-pelvic cyst USamp CT images

US of polycystic kidney disease

Renal infection

US of acute pyelonephritis

Acute bacterial pyelonephritis (a) US scan shows a wedge-shaped hyperechoic focus (arrowhead) in the upper pole of the right kidney related to acute bacterial pyelonephritis (b) Color flow US image demonstrates diminished flow through the involved area

US and color Doppler images of right kidney shows focal hyperechoic nephritis with decreased perfusion at the Doppler US

US and color Doppler images of kidney shows two multifocal nephritis with decreased perfusion at the Doppler US

Masslike appearance of acute bacterial pyelonephritis US and CT images

Emphysematous pyelonephritis (a) US image shows nondependent echoes within the left kidney that demonstrate a ring-down artifact (b) Corresponding CT scan helps confirm that this pattern is caused by intraparenchymal air

Xanthogranulomatous pyelonephritis (a) Contrast-enhanced CT scan demonstrates bilateral staghorn calculi with distention of the right collecting system secondary to inflammatory debris (b) US scan also shows the dilated

collecting system (arrowheads) and a shadowing calculus (arrow)

Early and mature abscess cavities (a) US scan demonstrates a geographic hypoechoic focus from an abscess in the upper pole of the right kidney (b) On a US scan of a more mature abscess the cavity is better defined with a visible pseudocapsule and through transmission that is evidenced by increased echogenicity deep to the upper pole lesion

Pyohydronephrosis

Pyohydronephrosis

Renal hydatidosis is an insidious disease and patients

often present with nonspecific clinical signs or symptoms Presenting complaints are dull flank pain hematuria palpable flank mass hypertension and renal colic

Disseminated abdominal retroperitoneal and pelvic hydatid disease (a) The right kidney is pushed to the midline and the left kidney is hydronephrotic and shrunken by retroperitoneal hydatid cysts (b) Ultrasound of the abdomen showing cystic lesions in the retroperitoneum in the position of the kidneys

Hydatid disease of the kidney US and CT images

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 62: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Para-pelvic cyst USamp CT images

US of polycystic kidney disease

Renal infection

US of acute pyelonephritis

Acute bacterial pyelonephritis (a) US scan shows a wedge-shaped hyperechoic focus (arrowhead) in the upper pole of the right kidney related to acute bacterial pyelonephritis (b) Color flow US image demonstrates diminished flow through the involved area

US and color Doppler images of right kidney shows focal hyperechoic nephritis with decreased perfusion at the Doppler US

US and color Doppler images of kidney shows two multifocal nephritis with decreased perfusion at the Doppler US

Masslike appearance of acute bacterial pyelonephritis US and CT images

Emphysematous pyelonephritis (a) US image shows nondependent echoes within the left kidney that demonstrate a ring-down artifact (b) Corresponding CT scan helps confirm that this pattern is caused by intraparenchymal air

Xanthogranulomatous pyelonephritis (a) Contrast-enhanced CT scan demonstrates bilateral staghorn calculi with distention of the right collecting system secondary to inflammatory debris (b) US scan also shows the dilated

collecting system (arrowheads) and a shadowing calculus (arrow)

Early and mature abscess cavities (a) US scan demonstrates a geographic hypoechoic focus from an abscess in the upper pole of the right kidney (b) On a US scan of a more mature abscess the cavity is better defined with a visible pseudocapsule and through transmission that is evidenced by increased echogenicity deep to the upper pole lesion

Pyohydronephrosis

Pyohydronephrosis

Renal hydatidosis is an insidious disease and patients

often present with nonspecific clinical signs or symptoms Presenting complaints are dull flank pain hematuria palpable flank mass hypertension and renal colic

Disseminated abdominal retroperitoneal and pelvic hydatid disease (a) The right kidney is pushed to the midline and the left kidney is hydronephrotic and shrunken by retroperitoneal hydatid cysts (b) Ultrasound of the abdomen showing cystic lesions in the retroperitoneum in the position of the kidneys

Hydatid disease of the kidney US and CT images

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 63: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

US of polycystic kidney disease

Renal infection

US of acute pyelonephritis

Acute bacterial pyelonephritis (a) US scan shows a wedge-shaped hyperechoic focus (arrowhead) in the upper pole of the right kidney related to acute bacterial pyelonephritis (b) Color flow US image demonstrates diminished flow through the involved area

US and color Doppler images of right kidney shows focal hyperechoic nephritis with decreased perfusion at the Doppler US

US and color Doppler images of kidney shows two multifocal nephritis with decreased perfusion at the Doppler US

Masslike appearance of acute bacterial pyelonephritis US and CT images

Emphysematous pyelonephritis (a) US image shows nondependent echoes within the left kidney that demonstrate a ring-down artifact (b) Corresponding CT scan helps confirm that this pattern is caused by intraparenchymal air

Xanthogranulomatous pyelonephritis (a) Contrast-enhanced CT scan demonstrates bilateral staghorn calculi with distention of the right collecting system secondary to inflammatory debris (b) US scan also shows the dilated

collecting system (arrowheads) and a shadowing calculus (arrow)

Early and mature abscess cavities (a) US scan demonstrates a geographic hypoechoic focus from an abscess in the upper pole of the right kidney (b) On a US scan of a more mature abscess the cavity is better defined with a visible pseudocapsule and through transmission that is evidenced by increased echogenicity deep to the upper pole lesion

Pyohydronephrosis

Pyohydronephrosis

Renal hydatidosis is an insidious disease and patients

often present with nonspecific clinical signs or symptoms Presenting complaints are dull flank pain hematuria palpable flank mass hypertension and renal colic

Disseminated abdominal retroperitoneal and pelvic hydatid disease (a) The right kidney is pushed to the midline and the left kidney is hydronephrotic and shrunken by retroperitoneal hydatid cysts (b) Ultrasound of the abdomen showing cystic lesions in the retroperitoneum in the position of the kidneys

Hydatid disease of the kidney US and CT images

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 64: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Renal infection

US of acute pyelonephritis

Acute bacterial pyelonephritis (a) US scan shows a wedge-shaped hyperechoic focus (arrowhead) in the upper pole of the right kidney related to acute bacterial pyelonephritis (b) Color flow US image demonstrates diminished flow through the involved area

US and color Doppler images of right kidney shows focal hyperechoic nephritis with decreased perfusion at the Doppler US

US and color Doppler images of kidney shows two multifocal nephritis with decreased perfusion at the Doppler US

Masslike appearance of acute bacterial pyelonephritis US and CT images

Emphysematous pyelonephritis (a) US image shows nondependent echoes within the left kidney that demonstrate a ring-down artifact (b) Corresponding CT scan helps confirm that this pattern is caused by intraparenchymal air

Xanthogranulomatous pyelonephritis (a) Contrast-enhanced CT scan demonstrates bilateral staghorn calculi with distention of the right collecting system secondary to inflammatory debris (b) US scan also shows the dilated

collecting system (arrowheads) and a shadowing calculus (arrow)

Early and mature abscess cavities (a) US scan demonstrates a geographic hypoechoic focus from an abscess in the upper pole of the right kidney (b) On a US scan of a more mature abscess the cavity is better defined with a visible pseudocapsule and through transmission that is evidenced by increased echogenicity deep to the upper pole lesion

Pyohydronephrosis

Pyohydronephrosis

Renal hydatidosis is an insidious disease and patients

often present with nonspecific clinical signs or symptoms Presenting complaints are dull flank pain hematuria palpable flank mass hypertension and renal colic

Disseminated abdominal retroperitoneal and pelvic hydatid disease (a) The right kidney is pushed to the midline and the left kidney is hydronephrotic and shrunken by retroperitoneal hydatid cysts (b) Ultrasound of the abdomen showing cystic lesions in the retroperitoneum in the position of the kidneys

Hydatid disease of the kidney US and CT images

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 65: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

US of acute pyelonephritis

Acute bacterial pyelonephritis (a) US scan shows a wedge-shaped hyperechoic focus (arrowhead) in the upper pole of the right kidney related to acute bacterial pyelonephritis (b) Color flow US image demonstrates diminished flow through the involved area

US and color Doppler images of right kidney shows focal hyperechoic nephritis with decreased perfusion at the Doppler US

US and color Doppler images of kidney shows two multifocal nephritis with decreased perfusion at the Doppler US

Masslike appearance of acute bacterial pyelonephritis US and CT images

Emphysematous pyelonephritis (a) US image shows nondependent echoes within the left kidney that demonstrate a ring-down artifact (b) Corresponding CT scan helps confirm that this pattern is caused by intraparenchymal air

Xanthogranulomatous pyelonephritis (a) Contrast-enhanced CT scan demonstrates bilateral staghorn calculi with distention of the right collecting system secondary to inflammatory debris (b) US scan also shows the dilated

collecting system (arrowheads) and a shadowing calculus (arrow)

Early and mature abscess cavities (a) US scan demonstrates a geographic hypoechoic focus from an abscess in the upper pole of the right kidney (b) On a US scan of a more mature abscess the cavity is better defined with a visible pseudocapsule and through transmission that is evidenced by increased echogenicity deep to the upper pole lesion

Pyohydronephrosis

Pyohydronephrosis

Renal hydatidosis is an insidious disease and patients

often present with nonspecific clinical signs or symptoms Presenting complaints are dull flank pain hematuria palpable flank mass hypertension and renal colic

Disseminated abdominal retroperitoneal and pelvic hydatid disease (a) The right kidney is pushed to the midline and the left kidney is hydronephrotic and shrunken by retroperitoneal hydatid cysts (b) Ultrasound of the abdomen showing cystic lesions in the retroperitoneum in the position of the kidneys

Hydatid disease of the kidney US and CT images

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 66: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Acute bacterial pyelonephritis (a) US scan shows a wedge-shaped hyperechoic focus (arrowhead) in the upper pole of the right kidney related to acute bacterial pyelonephritis (b) Color flow US image demonstrates diminished flow through the involved area

US and color Doppler images of right kidney shows focal hyperechoic nephritis with decreased perfusion at the Doppler US

US and color Doppler images of kidney shows two multifocal nephritis with decreased perfusion at the Doppler US

Masslike appearance of acute bacterial pyelonephritis US and CT images

Emphysematous pyelonephritis (a) US image shows nondependent echoes within the left kidney that demonstrate a ring-down artifact (b) Corresponding CT scan helps confirm that this pattern is caused by intraparenchymal air

Xanthogranulomatous pyelonephritis (a) Contrast-enhanced CT scan demonstrates bilateral staghorn calculi with distention of the right collecting system secondary to inflammatory debris (b) US scan also shows the dilated

collecting system (arrowheads) and a shadowing calculus (arrow)

Early and mature abscess cavities (a) US scan demonstrates a geographic hypoechoic focus from an abscess in the upper pole of the right kidney (b) On a US scan of a more mature abscess the cavity is better defined with a visible pseudocapsule and through transmission that is evidenced by increased echogenicity deep to the upper pole lesion

Pyohydronephrosis

Pyohydronephrosis

Renal hydatidosis is an insidious disease and patients

often present with nonspecific clinical signs or symptoms Presenting complaints are dull flank pain hematuria palpable flank mass hypertension and renal colic

Disseminated abdominal retroperitoneal and pelvic hydatid disease (a) The right kidney is pushed to the midline and the left kidney is hydronephrotic and shrunken by retroperitoneal hydatid cysts (b) Ultrasound of the abdomen showing cystic lesions in the retroperitoneum in the position of the kidneys

Hydatid disease of the kidney US and CT images

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 67: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

US and color Doppler images of right kidney shows focal hyperechoic nephritis with decreased perfusion at the Doppler US

US and color Doppler images of kidney shows two multifocal nephritis with decreased perfusion at the Doppler US

Masslike appearance of acute bacterial pyelonephritis US and CT images

Emphysematous pyelonephritis (a) US image shows nondependent echoes within the left kidney that demonstrate a ring-down artifact (b) Corresponding CT scan helps confirm that this pattern is caused by intraparenchymal air

Xanthogranulomatous pyelonephritis (a) Contrast-enhanced CT scan demonstrates bilateral staghorn calculi with distention of the right collecting system secondary to inflammatory debris (b) US scan also shows the dilated

collecting system (arrowheads) and a shadowing calculus (arrow)

Early and mature abscess cavities (a) US scan demonstrates a geographic hypoechoic focus from an abscess in the upper pole of the right kidney (b) On a US scan of a more mature abscess the cavity is better defined with a visible pseudocapsule and through transmission that is evidenced by increased echogenicity deep to the upper pole lesion

Pyohydronephrosis

Pyohydronephrosis

Renal hydatidosis is an insidious disease and patients

often present with nonspecific clinical signs or symptoms Presenting complaints are dull flank pain hematuria palpable flank mass hypertension and renal colic

Disseminated abdominal retroperitoneal and pelvic hydatid disease (a) The right kidney is pushed to the midline and the left kidney is hydronephrotic and shrunken by retroperitoneal hydatid cysts (b) Ultrasound of the abdomen showing cystic lesions in the retroperitoneum in the position of the kidneys

Hydatid disease of the kidney US and CT images

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 68: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

US and color Doppler images of kidney shows two multifocal nephritis with decreased perfusion at the Doppler US

Masslike appearance of acute bacterial pyelonephritis US and CT images

Emphysematous pyelonephritis (a) US image shows nondependent echoes within the left kidney that demonstrate a ring-down artifact (b) Corresponding CT scan helps confirm that this pattern is caused by intraparenchymal air

Xanthogranulomatous pyelonephritis (a) Contrast-enhanced CT scan demonstrates bilateral staghorn calculi with distention of the right collecting system secondary to inflammatory debris (b) US scan also shows the dilated

collecting system (arrowheads) and a shadowing calculus (arrow)

Early and mature abscess cavities (a) US scan demonstrates a geographic hypoechoic focus from an abscess in the upper pole of the right kidney (b) On a US scan of a more mature abscess the cavity is better defined with a visible pseudocapsule and through transmission that is evidenced by increased echogenicity deep to the upper pole lesion

Pyohydronephrosis

Pyohydronephrosis

Renal hydatidosis is an insidious disease and patients

often present with nonspecific clinical signs or symptoms Presenting complaints are dull flank pain hematuria palpable flank mass hypertension and renal colic

Disseminated abdominal retroperitoneal and pelvic hydatid disease (a) The right kidney is pushed to the midline and the left kidney is hydronephrotic and shrunken by retroperitoneal hydatid cysts (b) Ultrasound of the abdomen showing cystic lesions in the retroperitoneum in the position of the kidneys

Hydatid disease of the kidney US and CT images

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 69: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Masslike appearance of acute bacterial pyelonephritis US and CT images

Emphysematous pyelonephritis (a) US image shows nondependent echoes within the left kidney that demonstrate a ring-down artifact (b) Corresponding CT scan helps confirm that this pattern is caused by intraparenchymal air

Xanthogranulomatous pyelonephritis (a) Contrast-enhanced CT scan demonstrates bilateral staghorn calculi with distention of the right collecting system secondary to inflammatory debris (b) US scan also shows the dilated

collecting system (arrowheads) and a shadowing calculus (arrow)

Early and mature abscess cavities (a) US scan demonstrates a geographic hypoechoic focus from an abscess in the upper pole of the right kidney (b) On a US scan of a more mature abscess the cavity is better defined with a visible pseudocapsule and through transmission that is evidenced by increased echogenicity deep to the upper pole lesion

Pyohydronephrosis

Pyohydronephrosis

Renal hydatidosis is an insidious disease and patients

often present with nonspecific clinical signs or symptoms Presenting complaints are dull flank pain hematuria palpable flank mass hypertension and renal colic

Disseminated abdominal retroperitoneal and pelvic hydatid disease (a) The right kidney is pushed to the midline and the left kidney is hydronephrotic and shrunken by retroperitoneal hydatid cysts (b) Ultrasound of the abdomen showing cystic lesions in the retroperitoneum in the position of the kidneys

Hydatid disease of the kidney US and CT images

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 70: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Emphysematous pyelonephritis (a) US image shows nondependent echoes within the left kidney that demonstrate a ring-down artifact (b) Corresponding CT scan helps confirm that this pattern is caused by intraparenchymal air

Xanthogranulomatous pyelonephritis (a) Contrast-enhanced CT scan demonstrates bilateral staghorn calculi with distention of the right collecting system secondary to inflammatory debris (b) US scan also shows the dilated

collecting system (arrowheads) and a shadowing calculus (arrow)

Early and mature abscess cavities (a) US scan demonstrates a geographic hypoechoic focus from an abscess in the upper pole of the right kidney (b) On a US scan of a more mature abscess the cavity is better defined with a visible pseudocapsule and through transmission that is evidenced by increased echogenicity deep to the upper pole lesion

Pyohydronephrosis

Pyohydronephrosis

Renal hydatidosis is an insidious disease and patients

often present with nonspecific clinical signs or symptoms Presenting complaints are dull flank pain hematuria palpable flank mass hypertension and renal colic

Disseminated abdominal retroperitoneal and pelvic hydatid disease (a) The right kidney is pushed to the midline and the left kidney is hydronephrotic and shrunken by retroperitoneal hydatid cysts (b) Ultrasound of the abdomen showing cystic lesions in the retroperitoneum in the position of the kidneys

Hydatid disease of the kidney US and CT images

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 71: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Xanthogranulomatous pyelonephritis (a) Contrast-enhanced CT scan demonstrates bilateral staghorn calculi with distention of the right collecting system secondary to inflammatory debris (b) US scan also shows the dilated

collecting system (arrowheads) and a shadowing calculus (arrow)

Early and mature abscess cavities (a) US scan demonstrates a geographic hypoechoic focus from an abscess in the upper pole of the right kidney (b) On a US scan of a more mature abscess the cavity is better defined with a visible pseudocapsule and through transmission that is evidenced by increased echogenicity deep to the upper pole lesion

Pyohydronephrosis

Pyohydronephrosis

Renal hydatidosis is an insidious disease and patients

often present with nonspecific clinical signs or symptoms Presenting complaints are dull flank pain hematuria palpable flank mass hypertension and renal colic

Disseminated abdominal retroperitoneal and pelvic hydatid disease (a) The right kidney is pushed to the midline and the left kidney is hydronephrotic and shrunken by retroperitoneal hydatid cysts (b) Ultrasound of the abdomen showing cystic lesions in the retroperitoneum in the position of the kidneys

Hydatid disease of the kidney US and CT images

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 72: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Early and mature abscess cavities (a) US scan demonstrates a geographic hypoechoic focus from an abscess in the upper pole of the right kidney (b) On a US scan of a more mature abscess the cavity is better defined with a visible pseudocapsule and through transmission that is evidenced by increased echogenicity deep to the upper pole lesion

Pyohydronephrosis

Pyohydronephrosis

Renal hydatidosis is an insidious disease and patients

often present with nonspecific clinical signs or symptoms Presenting complaints are dull flank pain hematuria palpable flank mass hypertension and renal colic

Disseminated abdominal retroperitoneal and pelvic hydatid disease (a) The right kidney is pushed to the midline and the left kidney is hydronephrotic and shrunken by retroperitoneal hydatid cysts (b) Ultrasound of the abdomen showing cystic lesions in the retroperitoneum in the position of the kidneys

Hydatid disease of the kidney US and CT images

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 73: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Pyohydronephrosis

Pyohydronephrosis

Renal hydatidosis is an insidious disease and patients

often present with nonspecific clinical signs or symptoms Presenting complaints are dull flank pain hematuria palpable flank mass hypertension and renal colic

Disseminated abdominal retroperitoneal and pelvic hydatid disease (a) The right kidney is pushed to the midline and the left kidney is hydronephrotic and shrunken by retroperitoneal hydatid cysts (b) Ultrasound of the abdomen showing cystic lesions in the retroperitoneum in the position of the kidneys

Hydatid disease of the kidney US and CT images

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 74: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Pyohydronephrosis

Renal hydatidosis is an insidious disease and patients

often present with nonspecific clinical signs or symptoms Presenting complaints are dull flank pain hematuria palpable flank mass hypertension and renal colic

Disseminated abdominal retroperitoneal and pelvic hydatid disease (a) The right kidney is pushed to the midline and the left kidney is hydronephrotic and shrunken by retroperitoneal hydatid cysts (b) Ultrasound of the abdomen showing cystic lesions in the retroperitoneum in the position of the kidneys

Hydatid disease of the kidney US and CT images

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 75: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Renal hydatidosis is an insidious disease and patients

often present with nonspecific clinical signs or symptoms Presenting complaints are dull flank pain hematuria palpable flank mass hypertension and renal colic

Disseminated abdominal retroperitoneal and pelvic hydatid disease (a) The right kidney is pushed to the midline and the left kidney is hydronephrotic and shrunken by retroperitoneal hydatid cysts (b) Ultrasound of the abdomen showing cystic lesions in the retroperitoneum in the position of the kidneys

Hydatid disease of the kidney US and CT images

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 76: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Hydatid disease of the kidney US and CT images

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 77: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Renal tuberculosisUltrasound findings in the diagnosis of renal tuberculosis have traditionally been described as limited Granulomatous mass lesions in the renal parenchyma can be seen as masses of mixed echogenicity with or without necrotic areas of caseation and calcifications In addition findings of mucosal thickening of the renal pelvis and ureter ureteral stricture and hydronephrosis are seen

Longitudinal gray-scale ultrasound of the right kidney demonstrates hypoechoic areas (arrows) in the renal cortex suggestive of lobar caseation in this known case of tuberculosis

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 78: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Longitudinal gray-scale sonography of the kidney in another patient who has renal tuberculosis demonstrates hypoechoic areas of caseous necrosis (large arrows) with dense peripheral calcification (small arrows)

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 79: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

HIV-associated nephropathy is the leading cause of renal failure in HIV-positive

patients accounting for 40 of cases of HIV-related renal disease The major sonographic finding is enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

Enlarged kidney increased cortical echogenicity loss of cortico-medullary differentiation and obliteration of the fat sinus

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 80: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

WHO histological classification of benign renal neoplasmsBenign renal tumours are histologically classified according to the WHO as follows Renal cell tumoursrenal oncocytomarenal papillary adenoma - renal adenomaMetanephric tumoursmetanephric adenoma of kidneymetanephric adenofibroma of kidneymetanephric stromal tumour of kidneyMesenchymal tumoursrenal angiomyolipomarenal leiomyomarenal haemangiomarenal lymphangiomareninomarenal fibromarenal schwannomaMixed tumourscystic nephromamixed epithelial and stromal tumour of kidney

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 81: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Small homogeneous vascularized peripheral tumor that proved to be an oncocytoma

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 82: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Large tumor in the lower pole of the kidney in a 28 year old female that biopsy proved to be a leiomyoma

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 83: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Transverse and longitudinal sonogram shows uniformly echogenic mass in upper pole of left kidney (K) that was proven to be angiomyolipoma

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 84: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Angiomyolipoma - In two US pictures we can see a round bright object in renal parenchyma

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 85: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Multilocular cystic nephroma with a mass composed of multiple

non communicating cysts Multilocular cystic nephroma with a

multilocular cystic mass in the renal hilum

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 86: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Hypertrophied column of Bertin mimicking a renal mass

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 87: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Dromedary hump - Parenchyma of the left kidney is broader in its lateral part

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 88: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Renal adenoma

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 89: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Malignant renal tumourAdultrenal cell carcinoma (RCC) - most commonmedullary carcinoma of the kidney - young adults with sickle cell trait renal sarcoma - rareprimary renal lymphoma ndash rareLeukemic involvement of kidneycollecting duct carcinoma - rare considered a subtype of RCC by some

PediatricWilms tumour - most common pediatric renal malignancyrenal clear cell sarcoma - raremalignant rhabdoid tumour - rareSecondary(Metastasis)

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 90: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Renal cell carcinoma (RCC also known as hypernephroma

Grawitz tumor renal adenocarcinoma) is a kidney cancer that originates in the lining of the proximal convoluted tubule a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine RCC is the most common type of kidney cancer in adults responsible for approximately 90-95 of cases Initial treatment is most commonly either partial or complete removal of the affected kidney(s) and remains the mainstay of curative treatment Where the cancer has not metastasized (spread to other organs) or burrowed deeper into the tissues of the kidney the 5-year survival rate is 65-90 but this is lowered considerably when the cancer has spread It is relatively resistant to radiation therapy and chemotherapy although some cases respond to targeted therapies such as sunitinib temsirolimus bevacizumab interferon alfa and sorafenib which have improved the outlook for RCC

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 91: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Renal cell carcinoma with a large hypoechoic renal mass

Large renal cell carcinoma (adenocarcinoma) with calyceal impression and deviated but patent renal artery and vein

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 92: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Renal cell carcinoma (adenocarcinoma)

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 93: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Renal cell carcinoma (adenocarcinoma) with cystic spaces

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 94: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Renal transitional cell carcinoma

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 95: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Renal transitional cell carcinoma

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 96: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Squamous cell carcinoma

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 97: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Squamous cell carcinoma

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 98: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Ultrasound shows large solid mass arising from upper pole of right kidney(Wilms tumour)

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 99: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

RENAL CELL CARCINOMA Solid hyperechoic renal mass deforming the shape of the kidney related nephroblastoma

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 100: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Nephroblastoma or Wilms tumor with a large 7 cm isoechoic vascularized renal mass

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 101: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Abdominal ultrasound solid renal mass showing spur sign with superior pole of the kidney The final diagnosis was a nephroblastoma

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 102: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Clear cell sarcoma with an inhomogenous mass arising from the right kidney

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 103: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Renal leukemic infiltration with massively enlarged kidneys with diffuse infiltration of the renal cortex with sparing of the adjacent medulla

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 104: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Burkitt-like aggressive lymphoma

B-cell renal lymphoma

Renal metastases

Thank You

Page 105: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

B-cell renal lymphoma

Renal metastases

Thank You

Page 106: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Renal metastases

Thank You

Page 107: Presentation1.pptx, ultrasound examination of the adrenal glands and kidneys

Thank You