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  • P R E S E N T E D B Y

    #FindingSolutions

  • P R E S E N T I N G S P O N S O R

    G O L D S P O N S O R S

    S I L V E R S P O N S O R SDr. Wayne and Donna Anderson

    Blue Cross NCNorth Carolina Biotechnology Center

    PRA Health Sciences

  • R U B Y S P O N S O R

    B R O N Z E S P O N S O R S

    C R Y S T A L S P O N S O R SDr. Shelton EarpElizabeth Savage

    Ellis & Winters, LLPGregory B. Williams Foundation

    NCCULilly

    Lisa SykesPfizer

    RTP FoundationValencia Davis

    Wake Radiology

    Merck

    IBMSage Island

    #FindingSolutions

  • #FindingSolutions

  • https://www.youtube.com/watch?v=P6HAN-XAcnI

    https://www.youtube.com/watch?v=P6HAN-XAcnI

  • #FindingSolutions

  • The Changing Face ofBreast Cancer

    George W. Sledge MDStanford University School of

    Medicine

  • 40,000 Women & Men

    per year

    Why?

  • Why Does Breast Cancer Kill and What Can We Do About It?

    • What We Know– Local therapy cures many early stage breast cancers– Late stage breast cancer is usually incurable

    • What kills?– Disparities– Drug-resistant metastatic disease

  • Breast Cancer Molecular Subtypes

    Courtesy Chuck Perou

    Luminal B

    Luminal ANormal

    breast-likeLumina

    l B2 Basal-like HER2+/ER-

    Breast cancer is not one disease.But a group of biologically distinct diseases.

    What does this mean?

    It means that it does not make sense to ask “what causes breast cancer?”

    It also means that individualized medicine is not just desirable, it is crucial.

  • Breast Cancer as Whack-a-Mole

    Rapid emergence of resistance

  • “Here's my sequence...”

    The New Yorker

  • Liquid Biopsy: Circulating Tumor DNA

    and Circulating Tumor Cells

  • CTCs to Detect Late Recurrence of ER-Positive

    Breast Cancer: EL112 study• Patients enrolled in parent adjuvant

    trial (E5103) underwent single time point blood collection 4.5-7.5 years from diagnosis

    • CellSearch (EpCAM) assay performed

    • Recurrence rates per person-year:• 21.4% for CTC+ vs 2.0% CTC-

  • What Cancer Cells Do To T Cells:These aren’t the droids you’re looking for

  • 22

  • P R E S E N T E D B Y

    #FindingSolutions

  • Dr. Melissa Troester

    Co-Principal Investigator Carolina Breast Cancer Study

    Co-Leader Lineberger Comprehensive Cancer Center’s Cancer Epidemiology Program

    #FindingSolutions

  • Dr. George SledgeProfessor of Medicine and Chief

    Division of Oncology, Stanford University School of Medicine

    Co-Director Stanford Cancer Institute’s Translational Oncology Program

    #FindingSolutions

  • Dr. Donald McDonnellCo-Director Women’s Cancer Program,

    Duke Cancer Institute

    Glaxo-Wellcome Professor of Molecular Cancer Biology

    Chairman of the Department of Pharmacology & Cancer Biology at Duke University School of Medicine

    #FindingSolutions

  • Dr. Charles PerouCo-Director UNC Computational Medicine Program

    May Goldman Shaw Distinguished Professor of Molecular Oncology

    Professor of Genetics and of Pathology & Laboratory Medicine at the University of North Carolina

    #FindingSolutions

  • Jen Hoverstad

    #FindingSolutions

    Breast Cancer SurvivorBrand Manager, Counter Culture Coffee

    Attorney at Law

  • P R E S E N T E D B Y

    #FindingSolutions

  • BOLD GOAL

    REDUCTION in current breast cancer deaths

    in the U.S. by 2026

    50%

    #FindingSolutions

  • #FindingSolutions

  • 2018 KOMEN NCTC AWARDS

    #FindingSolutions

  • MAUREEN THOMAS JORDAN SPIRIT OF SURVIVORSHIP/THRIVERSHIP AWARD

  • MAUREEN THOMAS JORDAN SPIRIT OF SURVIVORSHIP/THRIVERSHIP AWARD

  • MAUREEN THOMAS JORDAN SPIRIT OF SURVIVORSHIP/THRIVERSHIP AWARD

  • MAUREEN THOMAS JORDAN SPIRIT OF SURVIVORSHIP/THRIVERSHIP AWARD

  • P R E S E N T E D B Y

    Thank You!

    #FindingSolutions

    Slide Number 1PRESENTING SPONSORRUBY SPONSOR���BRONZE SPONSORS�����CRYSTAL SPONSORSSlide Number 4Slide Number 5Slide Number 6Slide Number 7The Changing Face of�Breast CancerSlide Number 9Why Does Breast Cancer Kill and �What Can We Do About It?Slide Number 11Slide Number 12Slide Number 13Breast Cancer as Whack-a-MoleSlide Number 15Slide Number 16Slide Number 17Liquid Biopsy: Circulating Tumor DNA�and Circulating Tumor CellsCTCs to Detect Late Recurrence of ER-Positive Breast Cancer: EL112 studySlide Number 20What Cancer Cells Do To T Cells:�These aren’t the droids you’re looking forSlide Number 22Slide Number 23Dr. Melissa TroesterDr. George SledgeDr. Donald McDonnellDr. Charles PerouSlide Number 28Slide Number 29Slide Number 30Slide Number 312018 KOMEN NCTC �AWARDSMAUREEN THOMAS JORDAN SPIRIT OF SURVIVORSHIP/THRIVERSHIP AWARDMAUREEN THOMAS JORDAN SPIRIT OF SURVIVORSHIP/THRIVERSHIP AWARDMAUREEN THOMAS JORDAN SPIRIT OF SURVIVORSHIP/THRIVERSHIP AWARDMAUREEN THOMAS JORDAN SPIRIT OF SURVIVORSHIP/THRIVERSHIP AWARDSlide Number 37