principia posthuman
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Elements of a Principia PosthumanHuman Body 2.0 Redesign, Democracy, and Next-generation IntelligenceTRANSCRIPT
Melanie Swan MS Futures Group
+1-650-681-9482@LaBlogga, @DIYgenomics
March 31, 2012, Sunnyvale CA
Slides: http://slideshare.net/LaBlogga
Image credit: Natasha Vita-More, Primo Posthuman
Elements of a Principia Posthuman
Human Body 2.0 Redesign, Democracy, and Next-generation Intelligence
March 31, 2012Principia Posthuman 2
About Melanie Swan
Founder DIYgenomics, futurist and applied genomics expert
Current projects: MelanieSwan.com Education: MBA Finance, Wharton; BA
French/Economics, Georgetown Univ Work experience: Fidelity, JP Morgan, iPass,
RHK/Ovum, Arthur Andersen Sample publications:
Source: http://melanieswan.com/publications.htm
Swan, M. Crowdsourced Health Research Studies: An Important Emerging Complement to Clinical Trials in the Public Health Research Ecosystem. J Med Internet Res 2012, Mar;14(2):e46.
Swan, M. Scaling crowdsourced health studies: the emergence of a new form of contract research organization. Personalized Medicine 2012, Mar;9(2):223-234.
Swan, M. Steady advance of stem cell therapies. Rejuvenation Res 2011, Dec;14(6):699-704. Swan, M., Hathaway, K., Hogg, C., McCauley, R., Vollrath, A. Citizen science genomics as a model for
crowdsourced preventive medicine research. J Participat Med 2010, Dec 23; 2:e20. Swan, M. Multigenic Condition Risk Assessment in Direct-to-Consumer Genomic Services. Genet Med
2010, May;12(5):279-88. Swan, M. Emerging patient-driven health care models: an examination of health social networks,
consumer personalized medicine and quantified self-tracking. Int J Environ Res Public Health 2009, 2, 492-525.
March 31, 2012Principia Posthuman 3
CONTACT presentations
Data Visualization in Second Life (2008)
Future of Life Sciences: the Great Convergence of Life and Technology (2009)
Revolutionizing Biology with Personal Genomes (2010)
Principia Posthuman (2012)
Slides: http://slideshare.net/LaBloggaImage credit: Natasha Vita-More, Primo Posthuman
March 31, 2012Principia Posthuman
The future is notoriously hard to predict
4
Positional nanoassembly
Young lady’s illustrated primer
March 31, 2012Principia Posthuman 5
Simple models for thinking about the future
Past Present Future
Image: http://www.sydmead.com
March 31, 2012Principia Posthuman 6
The role of time in thinking:GPS for the Mind exercise
Plot time orientation: certainty, possibility, probability www.mindtimemaps.com/start/contact
Image: http://www.mindtime.com
Source: Fortunato, VJ and Furey, JT. The theory of MindTime: The relationships between Future, Past, and Present thinking and psychological well-being and distress. Personality and Individual Differences. January 2011, 50(1), pp. 20-4. http://www.miindtime.com
certainty possibility
probability
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GPS for the Mind exercise
CONTACT GPS for the Mind exercise (4 minutes)
1. Sign up for a free account at www.mindtimemaps.com (use an anonymous name if you prefer)
2. Complete the GPS for the Mind exercise at the community site: www.mindtimemaps.com/start/contact
3. Results: return to the community site www.mindtimemaps.com/start/contact and click on the Groups icon, then CONTACT to see the results
Source: http://www.mindtimemaps.com
Image: Salvador Dali
March 31, 2012Principia Posthuman
Agenda
Context for Principia Posthuman Elements of a Principia Posthuman
Quantitative: science, human body 2.0 redesign Qualitative: social constructs, democracy Concepts: philosophy, next-generation
intelligence
Conclusion
March 31, 2012Principia Posthuman 9
Elements of a Principia Posthuman
PhilosophyConcerned with: Understanding
Art, aesthetics, economics, politics, societal design
Concerned with: Experience
Concepts
Qualitative
Quantitative Science and technologyConcerned with: Characterization
Next-generation intelligence
Democracy
Human Body 2.0 Redesign
Image: http://integral-options.blogspot.com
Aspen rhizome
March 31, 2012Principia Posthuman
Agenda
Context for Principia Posthuman Elements of a Principia Posthuman
Quantitative: science, human body 2.0 redesign Qualitative: social constructs, democracy Concepts: philosophy, next-generation
intelligence
Conclusion
March 31, 2012Principia Posthuman 11
Miniaturization trend, next node: microdots
Computing machinery
Room(s) size Handheld Invisible Non matter-based?
2050s2000s10-100 years ago 2100+
Information storage
DNA sequencing
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Information transmission eras
Painting, scrolls Press, Transistor DNA
Analog Digital Life code ?
?
2000-21001455 & 1950-200017,300 years ago 2100+
(Kuhnian paradigms, Foucauldian epistemes)
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Prominent artificial intelligence eras
Expert syst, CYC NLP, HTM, NCC Google, Watson
Enumeration Biomimicry Big data ?
?
2000s+1990s+1950s 2100+
March 31, 2012Principia Posthuman
Big data: personal health informatics
14Academic papers re: integrated health data streams: Auffray C, et al. Looking back at genomic medicine in 2011. Genome Med. 2012 Jan 30;4(1):9.
Chen R et al. Personal omics profiling reveals dynamic molecular and medical phenotypes. Cell. 2012 Mar 16;148(6):1293-307.
DNA: SNP mutations
Microbiomics
Proteomics
RNA expression profiling
Epigenetics
Health 2.0:Personal health
informaticsDNA: Structural
variation
Metabolomics
March 31, 2012Principia Posthuman
DNA sequencing: 10x/yr improvement
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Biology is an information technology
Image credit: http://pubs.acs.org/cen/_img/87/i50/8750cover2_law.gif
I hate you01001001001000000110100001100001011101000110010100100000011110010110111101110101
I love you 01001001001000000110110001101111011101100110010100100000011110010110111101110101
March 31, 2012Principia Posthuman 16
Biology is the information technology
Image credit: J. Craig Venter Institute
Image credit: Anthony Atala lab
Image credit: Thomas Matthiesen
Artificial cell booted to life
Algal biofuelImage credit: http://www.rexresearch.com
Whole organ decellularization and recellularization (heart)
Organ regeneration (urethra)
DNA nanotechnology latch box for drug delivery
Image credit: Aarhus University
March 31, 2012Principia Posthuman 1717
Agenda
Context for Principia Posthuman Elements of a Principia Posthuman
Quantitative: science, human body 2.0 redesign Qualitative: social constructs, democracy Concepts: philosophy, next-generation
intelligence
Conclusion
March 31, 2012Principia Posthuman
Agency: collective intelligence computing
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Crowdsourcing
Quantified self-tracking
DIYbio labs
Consumer blood tests
Citizen science
Concierge research
Consumer genomics
Health 2.0:Crowdsourced
health computing
Ambient mental performance optimization
Continuous sampling
March 31, 2012Principia Posthuman
Mobile is the platform
Explosive growth US: more cell phones (328 m) than people (315 m)1
One billion+ worldwide smartphone users by 20132
App downloads: 5 bn in 2010 versus 300 mn in 20094
Health-related apps: 7,0004
81% physicians using smartphones 20123
Studies: thousands recruited in months2
Intimate continuous interaction platform Phone loss noticed within 5 minutes vs. 1 hour for wallet loss Kids chat with Siri as virtual friend
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1Kang C. Number of cell phones exceeds US population. Washington Post. October 11, 2011.2Dufau S. Smart phone, smart science: how the use of smartphones can revolutionize research in cognitive science. PLoS One. 2011.3Kiser K. 25 ways to use your smartphone. Physicians share their favorite uses and apps. Minn Med. 2011. 4Boulos MN. How smartphones are changing the face of mobile and participatory healthcare. Biomed Eng Online. 2011.
Image credit: http://www.psfk.com
Image credit: tehgaygeek.blogspot.com
March 31, 2012Principia Posthuman
Participatory health activity landscape
20
(Light) Level of Engagement (Intense)
Social media
Mobile health apps
PHRs (personal
health records)
Consumer genomics
Image credit: Getty Images
DIYbio (do-it-yourself
biology)
Quantified self-tracking
Citizen science
March 31, 2012Principia Posthuman
DIYbio (do-it-yourself
biology)
Concepts in participatory health
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Quantified self-tracking
Citizen science
http://ezramagazine.cornell.edu
http://www.iab.keio.ac.jp
http://thecoolgadgets.com
March 31, 2012Principia Posthuman 22
Citizen science definition
Institutional science research
Citizen science health and biology
Citizen science: 200+ organizations1
1http://scienceforcitizens.net/finder
Performing scientific investigation without professional training in the field Image credit: http://www.southernfriedscience.com
March 31, 2012Principia Posthuman
Citizen science health – why now?
Tools Plummeting cost of genome sequencing Availability of consumer blood tests Online bioinformatics tools
Education and support Local DIYbio labs, online forums
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Image credits: http://www.biocurious.orgImage credit: http://diybionyc.blogspot.com
March 31, 2012Principia Posthuman
Goal: personalized knowledge through quantified self-tracking
Format: monthly ‘show n tell’ meetups Outcome: optimality and improvement
Example: personalized interventions for depression, low energy, sleep quality
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Image credit: http://www.nationalpost.com Image credit: Quantified Self
Source: Swan, M. Overview of Crowdsourced Health Research Studies. 2012. Forthcoming.
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Quantified self study examples
Low-cost home-administered blood, urine, saliva tests
OrSense continuous non-invasive glucose monitoring
Cholestech LDX home cholesterol test
ZRT Labs dried blood spot tests
Food consumption (1 yr)1 and the Butter Mind study2
Study
1Source: http://flowingdata.com/2011/06/29/a-year-of-food-consumption-visualized2Source: http://quantifiedself.com/2011/01/results-of-the-buttermind-experiment
March 31, 2012Principia Posthuman 26
Health social networks and collaboration
Source: Extended from Swan, M. Emerging patient-driven health care models: an examination of health social networks, consumer personalized medicine and quantified self-tracking. Int. J. Environ. Res. Public Health 2009, 2, 492-525.
Health collaboration communities
Health social networks
(global & local)
March 31, 2012Principia Posthuman
Agenda
Context for Principia Posthuman Elements of a Principia Posthuman
Quantitative: science, human body 2.0 redesign Qualitative: social constructs, democracy Concepts: philosophy, next-generation
intelligence
Conclusion
March 31, 2012Principia Posthuman 28
Professionalizing participative health: Philosophical validation
Towards an epistemology of citizen science Provide a structure and context for participant-derived health
knowledge
Q1: Are new kinds of knowledge are being formed through group collaborations such as wikipedia and health social networks?
Q2: How to characterize the knowledge generated by traditional medicine, self-experimentation, and health collaboration communities?
Image credit: http://inkingrey.com
March 31, 2012Principia Posthuman 29
Ontological shift
Old thinking:
My health is the responsibility of my physician
New thinking:
My health is my responsibility
… and I have the tools to make managing it easy
Image credit: http://efx3.com
March 31, 2012Principia Posthuman
Genome politics and regulation
Our world is not Gattaca Personal genomics has
destigmatized health issues
Issues: human cloning, sex selection, genetic privacy, non-discrimination UN Convention on Human Rights and
Biomedicine 1997 (Ch IV Human Genome) U.S. Genetic Information Nondiscrimination
Act (GINA) 2008
Biocitizenry, health as a human right
Image credit: http://www.sonypictures.com
Image credit: http://sciencephoto.com
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March 31, 2012Principia Posthuman 31
Role of participative health: future medicine
Individual
2. Peer collaboration and health advisors
Health social networks, crowdsourced studies, health advisors, wellness coaches, preventive care plans,
boutique physicians, genetics coaches, aestheticians, medical tourism
3. Public health systemDeep expertise of traditional health system
for disease and trauma treatment
1. Continuous health information climate Automated digital health monitoring, self-tracking devices, and mobile apps providing personalized recommendations
Source: Extended from Swan, M. Emerging patient-driven health care models: an examination of health social networks, consumer personalized medicine and quantified self-tracking. Int. J. Environ. Res. Public Health 2009, 2, 492-525.
March 31, 2012Principia Posthuman 32
Health self-management
Source: Extended from Swan, M. Emerging patient-driven health care models: an examination of health social networks, consumer personalized medicine and quantified self-tracking. Int. J. Environ. Res. Public Health 2009, 2, 492-525, Figure 1.
A new model of health and health care
March 31, 2012Principia Posthuman
Biotechnicity and computational philosophy
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Computational tools of health-related philosophical discovery •Hardware and software devices and algorithms: quantitative health data streams, health-related smartphone applications, personal electronic health records, quantified self-tracking devices •Crowdsourced human computing networks: crowdsourced disease prediction, health social networks, quantified self n=1 health self-experimentation, crowdsourced health research studies, DIYbio labs
Epistemic advance: new knowledge generation•Content: New data streams, larger data sets, more granular data, higher order magnitude science•Process: New algorithms and new models
Metaphysical shift: new ways of being •Meaning of health and health outcomes•Sense of self and group identity, biocitizenry
Source: Swan, M. Biotechnicity 2.0: Computation-enabled Philosophical Advance in the Epistemology of Human Biology and the Ontology of Bioidentity. 2012. Submitted.
Image credit: http://stemcellresources.org
Concepts
Qualitative
Quantitative
March 31, 2012Principia Posthuman 3434
Agenda
Context for Principia Posthuman Elements of a Principia Posthuman
Quantitative: science, human body 2.0 redesign Qualitative: social constructs, democracy Concepts: philosophy, next-generation
intelligence
Conclusion
March 31, 2012Principia Posthuman 35
GPS for the Mind exercise
CONTACT GPS for the Mind exercise (4 minutes)
1. Sign up for a free account at www.mindtimemaps.com (use an anonymous name if you prefer)
2. Complete the GPS for the Mind exercise at the community site: www.mindtimemaps.com/start/contact
3. Results: return to the community site www.mindtimemaps.com/start/contact and click on the Groups icon, then CONTACT to see the results
Source: http://www.mindtimemaps.com
Image: Salvador Dali
March 31, 2012Principia Posthuman 36
GPS for the Mind results
Source: http://www.mindtimemaps.com
Image: Salvador Dali
Past, present, future Self, group, country
March 31, 2012Principia Posthuman 37
Elements of a Principia Posthuman
PhilosophyConcerned with: Understanding
Art, aesthetics, economics, politics, societal design
Concerned with: Experience
Concepts
Qualitative
Quantitative Science and technologyConcerned with: Characterization
Next-generation intelligence
Democracy
Human Body 2.0 Redesign
Image: http://integral-options.blogspot.com
Aspen rhizome
Slides: http://slideshare.net/LaBlogga
Creative Commons 3.0 license
Image: Natasha Vita-More, Primo Posthuman
Image: AmericanThinker.com
Melanie Swan MS Futures Group
+1-650-681-9482@LaBlogga, @DIYgenomics
Principia Posthuman
Thank you!Questions?
March 31, 2012Principia Posthuman 39
DIYgenomics participant-organized studies 7 studies in open enrollment (vitamin deficiency, aging, and
mental performance); 5 in design (oncology, calcinosis)
Source: Swan, M., Crowdsourced health research studies. J Med Internet Res 2012, Mar;14(2):e46