print pharma cns drugs
TRANSCRIPT
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THE central NERVOUS SYSTEM DRUGS
Ma. Biehn Kyrsti S. Guevarra, SN12
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Central Nervous System
Peripheral Nervous System
Brain Spinal Cord
Somatic NS
ANS
SympatheticParasympathetic
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CNS STIMULANTS
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I. AMPHETAMINES
• Stimulates the release of neurotransmitters – norepi and
dopamine
INDICATIONS: narcolepsy, ADHD
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I. AMPHETAMINESS/E and A/R: restlessness, insomnia,
tachycardia, HPN, heart palpitations, dry mouth, anorexia, weight loss, diarrhea or constipation, and impotence
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II. AMPHETAMINE-LIKE DRUGS
- increases child’s attention span, cognitive performance and to decrease impulsiveness, hyperactivity and restlessness
Ex: Methylphenidate (Ritalin) - ADHD
Pemoline (Cylert) – narcolepsy
Modafinil (Provigil) – newest, narcolepsy
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NURSING RESPONSIBILITIES
1. RITALIN and Pemoline should be given 30 to 45 minutes before meals (breakfast and lunch)
2. Give within 6 hours before sleep3. Instruct the patient to avoid driving4. Instruct the nursing mother to avoid
taking CNS stimulants5. Explain to client that long-term use may
lead to drug abuse.
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III. ANOREXIANTS
Aka as APPETITE SUPPRESSANTS
Ex: Phenylpropanolamine
S/E: nervousness, restlessness, irritability, insomnia, heart palpitations & HPN.
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III. ANALEPTICS
- stimulate respiration
Ex: METHYXANTHINES: caffeine &theophylline
S/E: nervousness, restlesness, tremors, twitchings, palpitations and insomnia, diuresis, GI irritation, tinnitus
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IV. RESPIRATORY CNS STIMULANTS
Ex: DOXAPRAM (DOPRAM)
-Treat respiratory depression caused by drug overdose, pre-post anesthetic respiratory depression, and COPD
• IV• S/E: HPN, tachycardia, trembling, and
convulsions
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HEADACHES: Migraine & Cluster
• Migraine headache : Classic & common• Cluster headache
TX:• Propranolol• Valproic acid• Aminotriptylline
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CNS DEPRESSANTS
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I. SEDATIVE-HYPNOTICS
• SEDATION – diminish physical and mental response at a lower dosages of certain CNS depressants but does not affect consciousness
• HYPNOTIC EFFECT – form of natural sleep
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I. SEDATIVE-HYPNOTICS
• Barbiturates• Benzodiazepines• Nonbenzodiazepines• Piperidinediones• Chloral Hydrate
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A. Barbiturates• LONG ACTING
-used to control seizures in epilepsyEx: Phenobarbital and Mephobarbital
• INTERMEDIATE-ACTING - sleep sustainers for maintaining
long period of sleepEx:- Amobarbital (Amytal)
- Aprobarbital (Alurate)- Butabarbital (Butisol)
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A. Barbiturates
• SHORT-ACTING- induce sleep for those difficulty
falling asleepEx:- Secobarbital (Seconal)
- Pentobarbital (Nembutal)
• ULTRASHORT-ACTING- general anesthetics
Ex: Thiopental Na (Pentothal)
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BARBITURATES NURSING RESPONSIBILITIES
• Raise bedside rails .• Check skin for rashes.• Do not mix pentobarbital w/ other
medications. • Teach client to use non pharmacologic ways
to induce sleep.• Instruct to avoid alcohol and antidepressant,
antipsychotic and narcotics.
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B. Benzodiazepines
ACTION: increase the action of inhibitory neurotransmitter GABA
Ex:• FLURAZEPAM (DALMANE) – first
- used to treat insomnia • Triazolam (Halcion) – A/R: loss of memory• Temazepam (Restoril), Estazolam (ProSom),
Quazepam (Doral)• Diazepam (Valium), Lorazepam (Ativan)
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BENZODIAZEPINES NURSING RESPONSIBILITIES
1. Teach non-pharmacologic ways to induce sleep
2. Avoid alcohol, antidepressants, antipsychotics
3. Urinate before taking the drug
4. No OTC drugs
5. Caution in driving
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C. Non-benzodiazepines
ZOLPIDEM (AMBIEN)
- Short term treatment of Insomnia
CHLORAL HYDRATE- Induces sleep and decrease nocturnal awakenings
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ANESTHETICS
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STAGES OF GENERAL ANESTHESIA
1. ANALGESIA
2. DELIRIUM OR EXCITEMENT
3. SURGICAL STAGE
4. MEDULLARY PARALYSIS
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BALANCED ANESTHESIA
Components: (HyPreSIM)• Hypnotic• Premedication (narcotic and
benzodiazepine) & anticholinergic• Short acting barbiturate• Inhaled gas• Muscle relaxant
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INHALATION ANESTHETICS
• Gas or volatile liquids• Nitrous oxide
Ex: Halothane, isoflurane, desflurane, enflurane, sevoflurane
Nitrous oxide, cyclopropane
A/R: respiratory depression, hypotension, dysrhythmias, hepatic dysfunction
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INTRAVENOUS ANESTHETICS
-May be used as general anesthesia
Ex: Thiopental sodium (pentothal)
Droperidol (Innovar)
Ketamine HCl (ketalar)
Midazolam (Versed) & Propofol (Diprivan)
A/R: respiratory and cardiovascular effects
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TOPICAL ANESTHETICS
• Mucous membrane; broken or unbroken skin surface, burns
• Solution, liquid spray, ointment, cream, and gel
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LOCAL ANESTHETICS
- Blocks pain at site where it’s administered & doesn’t produce loss of consciousness
Ex: Lidocaine (Xylocaine)
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SPINAL ANESTHESIA
- Local anesthesia is injected into subarachnoid space 3rd ot 4th lumbar space
Nerve block: spinal block (subarachnoid space); epidural block (dura mater); caudal block (near the sacrum); saddle block (lower end of spinal column)
S/E and A/R: respi distress, headache, hypotension
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ANTICONVULSANTS
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Classification of seizures
• Tonic-Clonic • Tonic• Clonic• Absence (Petit mal)• Myoclonic
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ANTICONVULSANTS
• Also called “ANTIEPILEPTICS”• ACTION: to suppress the
abnormal electrical impulses from the seizure focus to other cortical areas, preventing seizures
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Anticonvulsant ACTIONS
1. Suppress Na influx2. Suppress the Ca influx3. By increasing the action of
GABA
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Suppress Na influx Phenytoin, Fosphenytoin, Carbamazepine, Oxcarbazepine, Valproic acid,
Suppress Ca influx Valproic AcidEthosuximide
Enhance the action of GABA
BarbituratesBenzodiazepines
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HYDANTOINS
PHENYTOIN• First anticonvulsant • 1938• TERATOGENIC• Therapeutic range = 10-20 mcg/ml• IV, PO, no IM (tissue damage)
• S/E and A/R:gingival hyperplasiaslurred speechconfusiondepressionthrombocytopenialeukopeniahyperglycemiaNV, constipation
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BARBITURATES
PHENOBARBITAL
- partial, grand mal and status epilepticus
- teratogenic
- gradual discontinuance
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SUCCINIMIDES
- Used for absence or petit-mal seizures
ETHOSUXINIMIDE = succinimide of choice
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OXAZOLIDONES/ OXAZOLIDINEDIONE
- Used to treat petit-mal seizure
Ex: Trimethadione (first)
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BENZODIAZEPINES
CLONAZEPAM -petit-mal
CLORAZEPATE DIPOTASSIUM
- partial seizure
DIAZEPAM -acute status epilepticus- IV
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IMINOSTILBENES
Ex: Carbamazepine
– grand mal and partial seizures
- PO
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VALPROATE
• – petit-mal, grand mal, mixed types of seizures
Ex: Valproic acid
(hepatotoxic)
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NURSING RESPONSIBILITIES
PHENYTOIN
1. Shake the suspension well
2. Instruct client not to drive
3. No alcohol and antidepressants
4. Medic alert ID
5. Not to abruptly stop the drug therapy
6. No OTC
7. W/ food or milk
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NURSING RESPONSIBILITIES
PHENYTOIN
8. Instruct the client about the pinkish red urine / reddish brown.
9. Use a soft toothbrush.
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