product technical dossier para amino benzoic acid … · product technical dossier . para amino...

Product Code: P1602 Version: 1 of 15

PRODUCT TECHNICAL DOSSIER

PARA AMINO BENZOIC ACID (PABA) Product Code: P1602 Raw Material Full Name: Para amino benzoic acid Raw Material Full Botanical/Chemical/Latin/Trade Name/Synonyms: p-Aminobenzoic acid, Aniline-4-carboxylic acid, p-Carboxyaniline, PABA This material is Food Grade ✓ Vegan / Vegetarian Status Vegan ✓ Vegetarian ✓ Limit/Range/Specification: Min 98.5% CAS Number: 150-13-0 EC/EINECS Number: 205-753-0 Molecular Formula for the raw material: C7H7NO2 Average Molecular weight: 137.14 Solubility in Water: 1 g/170mL (25oC) Solubility in Alcohol: 125 g/L Particle Size: 50 Mesh Percentage passed through: 95%


Bulk Density: 0.29 - 0.35 g/mL Tapped Density: 0.43 - 0.53 g/mL Loss on Drying: Max 0.2% Residue on Ignition: Max 0.1% Country of Origin: China Country of Origin of the Manufacture: China Base Source/Start Material: p-Nitrobenzoic acid Origin of Product – Synthetic, Plant, Mineral, Animal, Fish or Fermented: Synthetic Solvents used: None Shelf Life from Date of Manufacture: 2 Years Storage Conditions: To be stored in sealed container and away from direct sunlight Appearance (Fine/Crystals/Crystalline/Hygroscopic): Crystalline powder Colour: White to off white Flavour/Taste: Characteristic Odour: Characteristic


Microbiological Test Total Viable Count: Max 10,000 cfu/g Yeast & Moulds: Max 1,000 cfu/g E.Coli: Negative Salmonella: Negative Heavy Metals: Max 20ppm Pharmacopeia Standard Used: USP There are no nuts in this recipe; however we cannot guarantee that the raw materials entering the site are nut free. Please note that surveillance testing may mean that not all the parameters stated on this specification are tested for every batch.


ALLERGENS Product

Free From YES/NO

Listed Item on Site at

Manufacturer YES/NO

If YES, Please Comment

Free from Peanuts and Peanut Derivatives (There are no nuts in this recipe, however CCL cannot guarantee that the raw materials entering the site are nut free.) YES NO

Free from other Nut and Nut Derivatives Almond (Amygdalus communis L.), Hazelnut (Corylus avellana), Walnut (Juglans regia), Cashew (Anacardium occidentale), Pecan nut (Carya illinoiesis (Wangenh.) K. Koch), Brazil nut (Bertholletia excelsa), Pistachio nut (Pistacia vera), Macadamia nut and Queensland nut (Macadamia ternifolia) (There are no nuts in this recipe, however CCL cannot guarantee that the raw materials entering the site are nut free.)

YES NO

Free from Sesame Seeds and Sesame Seed Derivatives YES NO Free from other Seeds and Seed Derivatives (Poppy Seeds, Cotton Seeds, Sunflower Seeds) YES NO

Free from Milk and Milk Derivatives (including lactose) YES NO Free from Egg and Egg Derivatives YES NO Free from Cereals and Derivatives containing OR POTENTIALLY CONTAMINATED WITH Gluten (wheat, wheatgrass, faro, freekeh, spelt, kamut, rye, oats, barley, barley grass)

YES NO

Free from Soya and Soya Derivatives YES NO Free from Lupin and Lupin Derivatives YES NO Free from Mustard and Mustard Derivatives YES NO Free from Celery or Celery Derivatives (including Celeriac) YES NO Free from Fish and Fish Derivatives YES NO Free from Molluscs and their Derivatives YES NO Free from Crustaceans and their Derivatives YES NO Free from Sulphur Dioxide and Sulphites (E220, E228) at levels > 10mg/kg or 10mg/litre YES NO


ADDITIVES / CONTAMINANTS / DIETARY REQUIREMENTS Product

Free From YES/NO

Listed Item on Site at

Manufacturer YES/NO

If YES, Please Comment

Free from Additives YES NO Free from Antioxidants YES NO Free from Ethylene Oxide YES NO Free from Gelatine YES NO Free from Flavourings (Artificial / Nature Identical / Natural / Smoked) YES NO Free from Maize / Corn and any Derivatives YES NO Free from Legumes / Pulses YES NO Free from Rice and Rice Derivatives YES NO Free from Added Salt YES NO Free from Added Sugar / artificial or natural sweeteners YES NO Free from Aspartame YES NO Free from BHA / BHT (E320 / E321) YES NO Free from Caffeine YES NO Free from Colours (Artificial / Nature Identical / Natural / Smoked) YES NO Free from Dextrose YES NO Free from Dioxins YES NO Free from MSG (Added and Naturally Occurring E621) or Glutamates (E620 to E625) YES NO Free from Nucleotides (E627, E630, E631, E635) YES NO Free from Polyols (sugar alcohols) YES NO Free from Benzoates (E210 / E219) YES NO Free from Sorbic Acid (E200, E203) YES NO Free from any other Preservatives YES NO Free from Ethanol YES NO Free from Honey YES NO Free from Lactose YES NO Free from Yeast and Yeast Derivatives YES NO Free from All Animal Products (Beef, Pork, Poultry or other) and Derivatives (which may include growth/yield hormones, antibiotics etc.) YES NO

Free from Bovine Products or Derivatives (which may include growth/yield hormones, antibiotics etc.) YES NO


PRODUCTION FLOW CHART

Para Nitrobenzoic Acid

↓ Catalyst / H2

Hydrogenate

↓

Centrifugalise

↓

Exsiccate

↓

PABA


CONFIRMATION OF BSE/TSE STATUS This is to certify that this product complies with all relevant current UK and EU Legislative requirements in regard to Transmissible Spongiform Encephalopathies (TSE) and Bovine Spongiform Encephalopathy (BSE) for human food, and so is free of TSE/BSE. This is also to certify that, during the course of their manufacture, the above-mentioned product did not come into contact with any materials, which could be derived from TSE/BSE risk materials. CONFIRMATION OF GM STATUS This is to certify that this product is not manufactured from GM raw materials and is therefore not subject to labelling under regulations 1829/2003/EC and 1830/2003/EC. CONFIRMATION OF NON IRRADIATION STATUS This is to certify that this product, whole or in part, has not been subjected to Ionising Radiation as per European Directives 1999/3/EC. CONFIRMATION OF NANDROLONE STATUS This is to certify that this product, whole or in part, has not come into contact with Nandrolone or any of its precursors in any way. CONFIRMATION OF IOC PRODUCT STATUS This is to certify that this product, whole or in part, has not come into contact with any product/s, which is banned by the IOC (International Olympics Committee) and or WADA.

CONFIRMATION OF ANIMAL TESTING STATUS This is to certify that all the products sold by Cambridge Commodities have not been tested on animals in any part of its manufacture in accordance with regulation 86/609/EEC. CONFIRMATION OF PESTICIDES STATUS This is to certify that the above-mentioned product complies with the regulation (EC) No.396/2005 of 23rd February 2005 and commission Regulation (EU) No. 559/2011 of 7th June 2011 amending annexes II and III of the above Regulation. CONFIRMATION OF NANOPARTICLE STATUS This is to certify that unless otherwise stated, the above-mentioned product is free of nanoparticles. Commission Recommendation 2011/696/EU, defines as follows: "'Nanomaterial' means a natural, incidental or manufactured material containing particles, in an unbound state or as an aggregate or as an agglomerate and where, for 50 % or more of the particles in the number size distribution, one or more external dimensions is in the size range 1 nm - 100 nm".


MATERIAL SAFETY DATA SHEET

1. IDENTIFICATION OF THE SUBSTANCE / PREPARATION Product name: 4-Aminobenzoic acid Synonym: PABA Product code: P1602 Supplier: Cambridge Commodities Limited

Lancaster Way, Ely, Cambridgeshire, CB6 3NX Tel: 01353 667258 Email: [email protected]

2. HAZARDS IDENTIFICATION

2.1 Classification of the substance or mixture In compliance with EC regulation no. 1272/2008 and its amendments Skin irritation, category 2 Eye irritation, category 2 Specific target organ toxicity (single exposure), Category 3. This substance does not present a physical hazard. Refer to the recommendations regarding the other products present on the site. This substance does not present an environmental hazard. No known or foreseeable environmental damage under standard conditions of use. In compliance with directives 67/548/EEC, 1999/45/EC and their amendments. Possibility of irritation to the eyes, by inhalation and skin. This substance does not present a physical hazard. Refer to the recommendations regarding the other products present on the site. This substance does not present an environmental hazard. No known or foreseeable environmental damage under standard conditions of use. 2.2 Label elements In compliance with EC regulation No. 1272/2008 and its amendments Hazard pictograms: GHS07


Signal word: WARNING Product identifiers: EC 205-753-0 PABA (ACIDE 4-AMINO BENZOIQUE) Hazard statements: H315 Causes skin irritation H319 Causes serious eye irritation. H335 May cause respiratory irritation. Precautionary statements - Prevention: P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P280 Wear protective gloves/protective clothing/eye protection/face protection. Precautionary statements - Response: P302 + P352 IF ON SKIN: Wash with plenty of soap and water. P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P35 l + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. In compliance with directives 67/548/EEC, 1999/45/EC and their amendments. Hazard symbols: Irritant

Risk phrase: R 36/37/38 Irritating to eyes, respiratory system and skin. Safety phrase: S 26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 36 Wear suitable protective clothing.


3. COMPOSITION/ INFORMATION ON INGREDIENTS

Substance: Name CAS no. EC no. %

PABA (Acide 4-amino benzoique) 150-13-0 205-753-0 100% Mixtures No substances fulfil the criteria set forth in annexe II section A of the REACH regulation (EC) n° 1907/2006. 4. FIRST AID MEASURES

As a general rule, in case of doubt or if symptoms persist, always call a doctor. NEVER induce swallowing by an unconscious person. 4.1 Description of first aid measures In the event of exposure by inhalation: In the event of massive inhalation of dust, remove the person exposed to fresh air. Keep warm and at rest. If the person is unconscious, place in recovery position. Notify a doctor in all events, to ascertain whether observation and supportive hospital care will be necessary. If breathing is irregular or has stopped, effect mouth-to-mouth resuscitation and call a doctor. In the event of splashes or contact with eyes: Wash thoroughly with soft, clean water for 15 minutes holding the eyelids open. If there is any redness, pain or visual impairment, consult an ophthalmologist. In the event of splashes or contact with skin: Remove contaminated clothing and wash the skin thoroughly with soap and water or a recognised cleaner. Watch out for any remaining product between skin and clothing, watches, shoes, etc. If the contaminated area is widespread and/or there is damage to the skin, a doctor must be consulted or the patient transferred to hospital In the event of swallowing: Do not give the patient anything orally. In the event of swallowing, if the quantity is small (no more than one mouthful), rinse the mouth with water and consult a doctor. Seek medical attention immediately, showing the label. 5. FIREFIGHTING MEASURES

Non-flammable. Special hazards arising from the substance or mixture A tire will often produce a thick black smoke. Exposure to decomposition products may be hazardous to health. Do not breathe in smoke.


In the event of a fire, the following may be formed: - Carbon monoxide (CO) - Carbon dioxide (CO2)

6. ACCIDENTAL RELEASE MEASURES

6.1 Personal precautions, protective equipment and emergency procedures Consult the safety measures listed under headings 7 and 8. For non-fire-fighters Avoid any contact with the skin and eyes. Avoid inhaling dust. If a large quantity has been spilt, evacuate all personnel and only allow intervention by trained operators quipped with safety apparatus. For fire-fighters Fire-fighters will be equipped with suitable personal protective equipment (See section 8). 6.2 Environmental precautions Prevent any material from entering drains or waterways. 6.3 Methods and material for containment and cleaning up Retrieve the product by mechanical means (sweeping/vacuuming). 7. HANDLING AND STORAGE

Requirements relating to storage premises apply to all facilities where the substance is handled. Precautions for safe handling Always wash hands after handling. Remove and wash contaminated clothing before re-using. Fire prevention: Handle in well-ventilated areas. Prevent access by unauthorised personnel. Recommended equipment and procedures: For personal protection, see section 8. Observe precautions stated on label and also industrial safety regulations Also provide breathing apparatus for certain short tasks of an exceptional nature and for emergency

interventions In all cases, recover emissions at source Avoid skin and eye contact with this substance Prohibited equipment and procedures: No smoking, eating or drinking in areas where the substance is used.


Storage Keep the container tightly closed in a dry, well-ventilated place Packaging Always keep in packaging made of an identical material to the original. 8. EXPOSURE CONTROLS / PERSONAL PROTECTION

8.2 Exposure controls Personal protection measures, such as personal protective equipment Pictogram(s) indicating the obligation of wearing personal protective equipment (PPE):

Use personal protective equipment that is clean and has been properly maintained. Store personal protective equipment in a clean place, away from the work area. Never eat, drink or smoke during use. Remove and wash contaminated clothing before re-using. Ensure that there is adequate ventilation, especially in confined areas. Eye / face protection Avoid contact with eyes. Before handling powders or dust emission, wear mask goggles in accordance with standard ENI 66. Prescription glasses are not considered as protection. Provide eyewash stations in facilities where the product is handled constantly. Hand protection Wear suitable protective gloves in the event of prolonged or repeated skin contact. Use suitable protective gloves that are resistant to chemical agents in accordance with standard EN374. Gloves must be selected according to the application and duration of use at the workstation. Protective gloves need to be selected according to their suitability for the workstation in question: other chemical products that may be handled, necessary physical protections (cutting, pricking, heat protection), level of dexterity required. Recommended properties: - Impervious gloves in accordance with standard EN374 Body protection Avoid skin contact. Wear suitable protective clothing Suitable type of protective clothing:


Wear protective clothing against solid chemicals and particles suspended in the air (type 5) in accordance with standard EN13982-l to prevent skin contact. Work clothing worn by personnel shall be laundered regularly. After contact with the product, all parts of the body that have been soiled must be washed. Respiratory protection Avoid breathing dust. If the ventilation is insufficient, wear appropriate breathing apparatus. When workers are confronted with concentrations that are above occupational exposure limits, they must wear a suitable, approved, respiratory protection device. Type of FFP mask: Wear a disposable half-mask dust filter in accordance with standard EN I 49. Category: FFP1 Anti-gas and vapour filter(s) (Combined filters) in accordance with standard ENl4387: A1 (Brown) 9. PHYSICAL AND CHEMICAL PROPERTIES

Physical state Solid Water solubility Soluble Partition coefficient: n-octanol/water: Log Pow:6,8 Melting point/melting range: 187oC

10. STABILITY AND REACTIVITY Chemical stability This substance is stable under the recommended handling and storage conditions in section 7. Conditions to avoid Avoid: - beating - heat - formation of dusts Dusts can form an explosive mixture with air. Incompatible materials Keep away from: - combustible material


Hazardous decomposition products The thermal decomposition may release/form: - carbon monoxide (CO) - carbon dioxide (CO2)

11. TOXICOLOGICAL INFORMATION

Information on toxicological effects May cause irreversible damage to the skin; namely inflammation of the skin or the formation of erythema and

eschar or oedema following exposure up to four hours. Repeated or prolonged contact with the substance may cause removal of natural oil from the skin resulting in

non-allergic contact dermatitis and absorption through the skin. May have reversible effects on the eyes, such as eye irritation which is totally reversible by the end of

observation at 21 days. Respiratory tract irritation may occur, together with symptoms such as coughing, choking and breathing difficulties.

Acute toxicity: Oral route: DL50 = 2850 mg/kg Species: Mouse Monograph(s) from the IARC (International Agency for Research on Cancer): CAS 150-13-0 IARC Group 3: The agent is not classifiable as to its carcinogenicity to humans. 12. ECOLOGICAL INFORMATION

No toxicity data is available for the substances. 13. DISPOSAL CONSIDERATIONS

Proper waste management of the substance and/or its container must be determined in accordance with Directive 2008/98/EC. Waste treatment methods Do not pour into drains or waterways. Waste: Waste management is carried out without endangering human health, without harming the environment and, in particular without risk to water, air, soil, plants or animals. Recycle or dispose of waste in compliance with current legislation, preferably via a certified collector or company. Do not contaminate the ground or water with waste, do not dispose of waste into the environment.


Soiled packaging: Empty container completely. Keep label(s) on container. Give to a certified disposal contractor. 14. TRANSPORT INFORMATION

Exempt from transport classification and labelling. Transport product in compliance with provision s of the ADR for road, RID for rail, CMDG for sea and TCAO/TATA

for air transport (ADR 2011-IMDG 2010 - ICAO/IATA 2011).

15. REGULATORY INFORMATION

No data available.

16. OTHER INFORMATION

This advice is given by Cambridge Commodities Ltd who accepts no legal liability for it. The information contained herein is based on the present state of our knowledge and is intended to describe our products from the point of view of safety requirements. It should not therefore be construed as guaranteeing specific properties. Individuals working with chemicals should consider all chemicals to be potentially hazardous even if their individual hazards may be uncharacterised or unknown. This Information provided in this document is subject to change and the batch specific Certificate of Analysis should always be referenced. To be used as per local legislation.

Change History

Version Change Customer Notification required Yes / No

1 First Issue N/A

Document Approval

Originator Job Title QC Technician Approver Job Title QC Technician

Adam Mulcahy (Mar 8, 2016)Adam Mulcahy

Casey Chung (Mar 8, 2016)Casey Chung

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P1602-Para Amino BenzoicAcid (PABA)-Technical DossierAdobe Document Cloud DocumentHistory

3/8/16

Created: 3/8/16

By: Adam Mulcahy ([email protected])

Status: SIGNED

Transaction ID: CBJCHBCAABAAUWTi86oLMiOtMOBBhvXtS6pKcv1hTVvg

“P1602-Para Amino Benzoic Acid (PABA)-Technical Dossier”History

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