1

CURRICULUM VITAE

SPYROS G. ZAKYNTHINOS

Professor of Pulmonary Medicine and Intensive Care

Athens University Medical School

PERSONAL DATA:

Date of Birth: 12 December 1955

Place of Birth: Lefkas, Greece

Citizenship: Greek

ADDRESS:

Office: Evangelismos Hospital

Critical Care Department

45-47 Ipsilandou St

GR-106 75 Athens

Greece

Telephone: 0030 210 7243320 / 0030 210 7201911

FAX: 0030 210 7216503

e-mail: szakynthinos@yahoo.com

EDUCATION:

Medical School of Athens University: 1973 - 1979

POSTGRADUATE TRAINING:

University Department of Diseases of the Chest, Athens, Greece:

Intern, Resident and Senior Resident in Pneumology

July 1982 - August 1986

Evangelismos Hospital, Athens, Greece

Lecturer / Assistant Professor / Associate Professor and Professor in Pulmonary and Critical Care Medicine

June 1992 – today

Meakins-Christie Laboratories, McGill University, Montreal, Quebec, Canada

Research Fellow

August 1991 - October 1991

Respiratory Muscle Research Unit, Laboratory of Pneumology, Katholieke Universiteit Leuven, Leuven,

Belgium

Visiting Investigator

June 1996 - August 1996

DEGREES AND QUALIFICATIONS:

M.D. University of Athens Graded: Very Good

PhD. University of Athens Graded: Excellent

EDIC European Diploma of Intensive Care

LICENSES:

Certified Specialist in Pneumology, Greece 1986

Certified Specialist in Critical Care, Greece 1989

APPOINTMENTS:

2

1992-1997 Lecturer in Critical Care, Athens University

Evangelismos Hospital

Athens, Greece

1997-2003 Assistant Professor in Critical Care Medicine, Athens University

Evangelismos Hospital

Athens, Greece

2003-2009 Associate Professor in Critical Care Medicine, Athens University

Evangelismos Hospital

Athens, Greece

2009-today Professor in Critical Care and Respiratory Medicine, National and Kapodistrian

University of Athens (NKUA)

2011-today Director of 1st Department of Critical Care of NKUA, Evangelismos Hospital

Athens, Greece

CLINICAL EXPERIENCE:

For 33 years (1986-2019) continue clinical work (after residency) in Pulmonary and Critical Care

Medicine in the Department of Critical Care and Pulmonary Medicine of Athens University, Evangelismos

Hospital, Athens, Greece.

EXPERIENCE IN MEDICAL EDUCATION:

Organization of Congresses

- 8th ERS Annual Congress 1995, Athens, Greece (member)

- 8th–13

th Congress of Hellenic Critical Care Society 2001-2010 (member)

- 24th-27

th Congress of Hellenic Thoracic Society 2016-2019 (president)

Organization of Post-Graduate courses/seminars

- Post-Graduate courses of Pulmonary and Critical Care Medicine 2004 and 2009, Athens, Greece

(president)

- Post-Graduate seminars in Pulmonary and Critical Care Medicine of Hellenic Critical Care

Society (per 2 years) 2000-2010 (member)

- Post-Graduate courses of Pulmonary and Critical Care Medicine, Autumn “Multidisciplinary”,

(per year) 1996-2009 (member)

- Post-Graduate courses of Pulmonary and Critical Care Medicine, “State of the Art”, (per year)

1996-2009 (member)

- Post-Graduate courses of Pulmonary and Critical Care Medicine of the 1st Department of Critical

Care of NKUA (Evangelismos Hospital, Athens, Greece), (2 per year) 1st-5

th 2017-2019

(president)

Teaching experience - Responsible for the organization of the Research seminars of the Department of Critical Care and

Pulmonary Medicine, Evangelismos Hospital (2002-2005)

- Teaching of undergraduate students (5th year) of the Medical School of Athens University in

Critical Care, Pulmonary and Emergency Medicine (1992-2000)

- Responsible for teaching of undergraduate students (5th year) of the Medical School of Athens

University in Critical Care Medicine (1997-2019), Pulmonary Medicine (2006-2010) and

Emergency Medicine (1992-2000)

- Contribution as a speaker in a) Post-Graduate seminars of Hellenic Bronchological Society,

annually (1989-2008), b) Post-Graduate seminars of Hellenic Thoracic Society (1996, 1998, 2000,

2002, 2004, 2005), and c) Post-Graduate seminars and courses of Hellenic Critical Care Society

and Hellenic Thoracic Society, annually (2000-2019)

- Member of the organizing committee and teacher in the Post-Graduate program of the Medical

School of Athens University, named “Critical Care Medicine and Emergency Nursing” (2006-

2007 and 2007-2008)

- Responsible for 10 PhD which have already finished (all achieved the highest value - excellent),

3

and other 23 PhD which have not finished yet. Member of the advisory committee of 22 additional

PhD, all from Medical School of Athens University

EDITOR, REVIEWER:

Associate Editor of the European Respiratory Journal (2000 – 2012)

Reviewer in 8 International Journals (permanent in European Respiratory Journal, Intensive Care

Medicine, American Journal of Respiratory and Critical Care Medicine, Chest and Critical Care Medicine;

infrequently in Pulmonary Pharmacology and Therapeutics, Pediatrics, and Journal of Clinical

Psychopharmacology)

PUBLICATIONS:

A. ORIGINAL ARTICLES IN ENGLISH (Peer Review, Indexed in Pubmed with Impact Factor) : 123

First author: 10

Second author: 15

Senior (last) author): 50

Basic research: 31

Clinical research: 92

Β. REVIEW/ etc ARTICLES IN ENGLISH (Peer Review, Indexed in Pubmed) : 35

Reviews: 29

Editorials: 5

Commentary: 1

C. LETTERS TO THE EDITOR IN ENGLISH (Indexed in Pubmed) : 22

D. CASE REPORTS/STUDIES IN ENGLISH (Indexed in Pubmed) : 19

Ε. BOOK CHAPTERS IN ENGLISH: 19

F. ARTICLES IN GREEK (Peer Review, Indexed in Iatrotek for Greek Journals) : 28

G. BOOK CHAPTERS IN GREEK : 27

4

PRESENTATION OF PUBLICATIONS IN ENGLISH

* indicates corresponding author # indicates study without Impact Factor

A. ORIGINAL ARTICLES (Peer Review, Indexed in Pubmed with Impact Factor)

1. Baltopoulos G, Zakynthinos S, Dimopoulos A, Roussos C.

Effects of furosemide on pulmonary shunts.

Chest 1989;96:494-498.

2. Spandidos D, Zakynthinos S, Petraki C, Sotsiou F, Yiagnisis M, Dimopoulos A, Roussos C.

Expression of Ras-p21 and myc-p62 oncoproteins in small cell and non-small cell carcinoma of

the lung.

Anticancer Research 1990;10:1105-1114.

3. Yan S, Lichros I, Zakynthinos S, Macklem PT.

Effect of diaphragmatic fatigue on control of respiratory muscles and ventilation during CO2

rebreathing.

J Appl Physiol 1993;75:1364-1370.

4. Yan S, Sliwinski P, Gauthier A, Lichros I, Zakynthinos S, Macklem PT.

Effect of global inspiratory muscle fatigue on ventilatory and respiratory muscle responses to CO2.

J Appl Physiol 1993;75:1371-1377.

5. Nakos G, Zakynthinos S, Kotanidou A, Tsagaris H, Roussos C.

Tracheal gas insufflation reduces the tidal volume while PaCO2 is maintained constant.

Intensive Care Med 1994;20:407-413.

6. Zakynthinos S,* Vassilakopoulos T, Roussos C.

The load of inspiratory muscles in patients needing mechanical ventilation.

Am J Respir Crit Care 1995;152:1248-1255.

7. Zakynthinos S,* Vassilakopoulos T, Zakynthinos E, Roussos C.

Accurate measurement of intrinsic positive end-expiratory pressure: How to detect and correct for

expiratory muscle contraction.

Eur Respir J 1997;10:522-529.

Editorial: Ninane V. “Intrinsic” PEEP (PEEPi): role of expiratory muscles. Eur Respir J

1997;10:516-518.

8. Kotanidou A, Armaganidis A, Zakynthinos S, Mavrommatis A, Roussos C.

Changes in thoracopulmonary compliance and hemodynamic effects of positive end-expiratory

pressure in patients with and without heart failure.

J Crit Care 1997; 12: 101-111.

9. Zakynthinos S,* Vassilakopoulos T, Daniil Z, Zakynthinos E, Koutsoukos E, Katsouyianni E,

Roussos C.

Pressure support ventilation in patients with ARDS. Short-term effects of a servo-controlled

mode.

J Crit Care 1997; 12: 161-172.

5

10. Tzelepis G, Zakynthinos S, Vassilakopoulos T, Geroulanos S, Roussos C.

Inspiratory maneuver effects on peak expiratory flow: Role of lung elastic recoil and expiratory

pressure

Am J Respir Crit Care 1997; 156: 1399-1404.

11. Vassilakopoulos T, Zakynthinos S,* Roussos C.

The tention - time index and the frequency / tidal volume ratio are the major pathophysiologic

determinants of weaning failure and success.

Am J Rerspir Crit Care 1998; 158: 378-385.

12. Routsi Ch, Bardouniotou H, Delivoria - Ioannidou V, Kazi D, Roussos C, Zakynthinos S.*

Pulmonary lactate release in patients with acute lung injury is not attributable to lung tissue

hypoxia.

Crit Care Med 1999; 27: 2469-2473.

Editorial: Mizock B.A. Lung injury and lactate production: A hypoxic stimulus? Crit Care Med

1999; 27: 2585-2586.

13. Zakynthinos S, Vassilakopoulos T, Mavrommatis A, Roussos C, Tzelepis G.

Effects of different expiratory maneuvers on inspiratory muscle force output.

Am J Respir Crit Care Med 1999; 159: 892-895.

14. Mavrommatis A, Theodoridis T, Orfanidou A, Roussos C, Christopoulou-Kokkinou V,

Zakynthinos S. *

Coagulation system and platelets are fully activated in uncomplicated sepsis.

Crit Care Med 2000; 28: 451-157.

Editorial: Kaplan K.L. Coagulation activation in sepsis. Crit Care Med 2000; 28: 585-586.

15. Zakynthinos S,* Vassilakopoulos T, Zakynthinos E, Roussos C, Tzelepis G.

Correcting static intrinsic positive end-expiratory pressure for expiratory muscle contraction.

Validation of a new method.

Am J Respir Crit Care Med 1999; 160: 785-790.

Selected for the Critical Care Journal Club web site of the ATS assembly on Critical Care, October

1999.

16. Vassilakopoulos T, Zakynthinos S, Roussos C.

Strenuous inspiratory resistive breathing produces proinflammatory cytokines and stimulates the

hypothalamic - pituitary - adrenal axis in humans.

Am J Physiol Regul Ιntegr Comp Physiol 1999; 277: R1013-R1019.

17. Zakynthinos S,* Vassilakopoulos T,Zakynthinos E, Mavrommatis A, Roussos C.

Contribution of expiratory muscle activity to dynamic intrinsic PEEP. Validation using the

Campbell diagram.

Am J Respir Crit Care Med 2000; 162: 1633-1640.

Editorial: Younes M. Dynamic intrinsic PEEP (PEEPi,dyn). Is it worth saving? Am J Respir Crit

Care Med 2000; 162: 1608-1609. Selected for the Critical Care Journal Club web site of the ATS

assembly on Critical Care, November 2000.

18. Vassilakopoulos T, Mastora Z, Katsaounou P, Doukas G, Klimopoulos S, Roussos C,

Zakynthinos S.

6

Contribution of pain to inspiratory muscle dysfunction after upper abdominal surgery. A

randomized controlled trial.

Am J Respir Crit Care Med 2000; 161: 1372-1375.

19. Vassilakopoulos T, Troupis T, Sotiropoulou C, Zacharatos P, Katsaounou P, Parthenis D, Noussia O,

Troupis G, Papiris S, Kittas C, Roussos C, Zakynthinos S, Gorgoulis V.

Diagnostic and prognostic significance of squamous cell carcinoma antigen in non small cell lung

cancer.

Lung Cancer 2001; 32: 137-144.

20. Zakynthinos E, Vassilakopoulos T, Mavrommati I, Fillipatos G, Roussos C, Zakynthinos S.

Echocardiographic and ambulatory electrocardiographic findings in elite water polo athletes.

Scand J Med Sci Sports 2001; 11: 149-55.

21. Papadavid E, Pignatelli M, Zakynthinos S, Krausz T, Chu AC.

The potential role of abnormal E-cadherin and alpha-, beta- and gamma-catenin immunoreactivity

in the determination of the biological behaviour of keratoacanthoma.

Br J Dermatol 2001; 145: 582-589.

22. Papadavid E, Pignatelli M, Zakynthinos S, Krausz T, Chu AC.

Abnormal immunoreactivity of the E-cadherin/catenin (alpha-, beta-, and gamma-) complex in

premalignant and malignant non-melanocytic tumours.

J Pathol 2002; 196: 154-162.

23. Mavrommatis A, Theodoridis T, Economou M, Kotanidou A, El Ali M, Christopoulou-Kokkinou

V, Zakynthinos S.

Activation of the fibrinolytic system and utilization of the coagulation inhibitors in sepsis :

comparison with severe sepsis and septic shock.

Intensive Care Med 2001; 27: 1853-1859.

24. Kosmidou I, Vassilakopoulos T, Xagorari A, Zakynthinos S, Papapetropoulos A, Roussos C.

Production of interleukin-6 by skeletal myotubes. Role of reactive oxygen species.

Am J Respir Cell Mol Biol 2002; 26: 587-593.

25. Vassilakopoulos T, Katsaounou P, Karantza M, Kollintza A, Zakynthinos S, Roussos C.

Strenuous resistive breathing induces plasma cytokines: role of antioxidants and monocytes.

Am J Respir Crit Care Med 2002; 166: 1572-1578.

26. Vassilakopoulos T, Karantza M, Katsaounou P, Kollintza A, Zakynthinos S, Roussos C.

Antioxidants attenuate the plasma cytokine response to exercise in humans.

J Appl Physiol 2003; 94: 1025-1032.

27. Corrado A, Roussos C, Ambrosino N, Colfalonieri M, Cuvelier A, Elliot M, Gorini M, Gurkan O,

Muir JF, Quareni L, Robert D, Rodenstein D, Rossi A, Schoenhofer B, Simonds AK, Strom K,

Torres A, Zakynthinos S.

Respiratory intensive care units: a European survey.

Eur Respir J 2002; 20: 1343-1350.

28. Metzelopoulos S, Zakynthinos S, Roussos C, Tzoufi MJ, Michalopoulos A

Prone positioning improves lung mechanical behavior and gas exchange in mechanically

ventilated chronic obstructive pulmonary disease patients.

Anesth Analg 2003; 96: 1756-1767.

7

Award winner of the “European Respiratory Society COPD award 2003” for Greece.

29. Zakynthinos E, Pierrutsakos C, Konstantinidis K, Zakynthinos S, Papadogiannis D.

Losartan reduces left ventricular hypertrophy proportionally to blood pressure reduction in

hypertensives, but does not affect the diastolic cardiac function.

Angiology 2004; 55: 669-678.

30. Zakynthinos E, Theodorakopoulou M, Daniil Z, Konstantinidis K, Zakynthinos S.

Hemorrhagic cardiac tamponade in critically ill patients with acute renal failure

Heart and Lung 2004; 33: 55-60.

31. Zakynthinos S,* Papanikolaou S, Theodoridis T, Zakynthinos EG, Christopoulou-Kokkinou V,

Katsaris G, Mavrommatis AC.

Sepsis severity is the major determinant of circulating thrombopoietin levels in septic patients. Crit

Care Med 2004; 32: 1004-10.

32. Metzelopoulos S, Roussos C, Zakynthinos S.

Prone position improves expiratory airway mechanics in severe chronic bronchitis.

Eur Respir J 2005; 25: 259-268.

33. Metzelopoulos S, Roussos C, Zakynthinos S.

Prone position reduces lung stress and strain in severe acute respiratory distress syndrome.

Eur Respir J 2005; 25: 534-544.

34. Giantsou E, Liratzopoulos N, Efraimidou E, Panopoulou E, Alepopoulou E, Kartali-Ktenidou S,

Minopoulos G, Zakynthinos S, Manolas K

Both early-onset and late-onset ventilator-associated pneumonia are caused mainly by potentially

multiresistant bacteria

Intensive Care Med 2005; 31: 1488-1494.

Editorial: Chastre J. Antibiotic prescribing for ventilator-accociated pneumonia: get it right from

the beginning but be able to rapidly deescalate Intensive Care Med 2005; 31: 1463-1465. Paper of

the month at the ESICM web site.

35. Zakynthinos S,* Routsi C, Vassilakopoulos T, Kaltsas P, Zakynthinos E , Kazi D,Roussos C,

Differential cardiovascular responses during weaning failure: effects on tissue oxygenation and

lactate.

Intensive Care Med 2005; 21: 1634-1642.

Editorial: Richard C, Teboul J-L. Weaning failure from cardiovascular origin. Intensive Care Med

2005; 31: 1605-1607. Paper of the month at the ESICM web site.

36. Metzelopoulos S, Tzoufi M, Rellos K, Michalopoulos A, Stamataki E, Roussos C, Zakynthinos

S.

An evaluation of McCoy banoon laryngoscopy in patients with moderate-to-major endotracheal

intubation difficulty.

Anesth Analg 2005; 101: 1233-1237.

37. Vogiatzis I, Georgiadou O, Golemati S, Aliverti A, Kosmas E, Kastanakis E, Geladas N,

Koutsoukou A, Nanas S, Zakynthinos S, Roussos C.

Chest wall volume changes during exercise and recovery in patients with severe chronic

obstructive pulmonary disease.

Thorax 2005; 60: 723-729.

8

38. Metzelopoulos S, Roussos C, Zakynthinos S.

Static pressure volume curves and body posture in acute respiratory failure.

Intensive Care Med 2005; 31:1683-1692.

39. Vogiatzis I, Terzis G, Nanas S, Stratakos G, Simoes D, Georgiadou O, Zakynthinos S, Roussos

C.

Skeletal muscle adaptations to interval training in patients with advanced COPD.

Chest 2005; 128: 3838-3845.

40. Routsi C, Giamarellos-Bourboulis EJ, Antonopoulou A, Kollias S, Siasiakou S, Koronaios A,

Zakynthinos S, Armaganidis A, Giamarellou H, Roussos C.

Does soluble triggering receptor expressed on myeloid cells-1 play any role in the pathogenesis of

septic shock?

Clin Exp Immunol 2005; 142: 62-67.

41. Tzelepis GE, Zakynthinos S, Mandros C, Tzelepis E, Roussos C.

Respiratory muscle performance with stretch-shortening cycle manoeuvres: maximal inspiratory

pressure-flow curves.

Acta Physiol Scand 2005; 185: 251-256.

42. Vassilakopoulos T, Routsi C, Bitsakou C, Sotiropoulou C, Stanopoulos J, Roussos C,

Zakynthinos S.*

The combination of the load/force balance and the frequency/tidal volume can predict weaning

outcome.

Intensive Care Med 2006; 32: 684-691.

43. Vogiatzis I, Georgiadou O, Giannopoulou I, Koskolou M, Zakynthinos S, Kostikas K, Kosmas E,

Wagner H, Peraki E, Koutsoukou A, Koulouris N, Wagner P, Roussos C.

Effects of exercise-induced arterial hypoxemia and work rate on diaphragmatic fatigue in highly-

trained endurance athletes.

J Physiol (London) 2006; 572: 539-549.

44. Tsigkos S, Zhou Z, Kotanidou A, Fulton D, Zakynthinos S, Roussos C, Papapetropoulos A

Regulation of Ang2 release by PTEN/PI3-kinase/Akt in lung microvascular endothelial cells.

J Cell Physiol 2006; 207: 506-511.

45. Giamarellos-Bourboulis EJ, Zakynthinos S, Baziaka F, Papadomichelakis E, Virtzili S,

Koutoukas P, Armaganidis A, Giamarellou H, Roussos C.

Soluble triggering receptor expressed on myeloid cells 1 as an anti-inflammatory mediator in

sepsis.

Intensive Care Med. 2006; 32: 237-243.

Editorial: Gibot S, Massin F. Soluble form of the triggering receptor expressed on myeloid cells 1:

An anti-inflammatory mediator? Intensive Care Med. 2006; 32:185-187.

46. Metzelopoulos S, Sigala I, Roussos C, Zakynthinos S.*

Static pressure volume curves and body posture in severe chronic bronchitis.

Eur Respir J 2006; 28: 165-174.

47. Zakynthinos S,* Katsaounou P, Karatza MH, Roussos C, Vassilakopoulos T

Antioxidants increase the ventilatory response to hyperoxic hypercapnia.

Am J Respir Crit Care Med 2007; 175: 62-68.

9

48. Koutsourelakis I, Vagiakis E, Roussos C, Zakynthinos S.*

Obstructive sleep apnoea and oral breathing in patients free of nasal obstruction.

Eur Respir J 2006; 28: 1222-1228.

49. Metzelopoulos S,Sourlas S,Koutsoukou A,Malachias S,LachanaA,Roussos C,Zakynthinos S.

Acute effects of combined high frequency oscillation and tracheal gas insufflation in severe acute

respiratory distress syndrome.

Crit Care Med 2007; 35: 1500-1508.

Editorial: Alistair N. High frequency oscillation in acute respiratory distress syndrome: Who

rescues the rescuer? Crit Care Med 2007; 35: 1619-1620.

50. Georgiadou O, Vogiatzis I, Stratakos G, Koutsoukou A, Golemati S, Aliverti A, Roussos C,

Zakynthinos S.

Effects of rehabilitation on chest wall volume regulation during exercise in COPD patients

Eur Respir J 2007; 29: 284-291.

51. Vogiatzis I, Stratakos G, Simoes D, Terzis G, Georgiadou O, Roussos C, Zakynthinos S.

Effects of rehabilitative exercise on peripheral muscle TNF-α, IL-6, IGF-I and MyoD expression

in patients with COPD.

Thorax 2007; 62:950-956.

52. Orfanos S, Kotanidou A, Glynos C, Athanasiou C, Tsigkos S, Dimopoulou I, Sotiropoulou C,

Zakynthinos S, Armaganidis A, Papapetropoulos A, Roussos C.

Angiopoietin-2 is increased in severe sepsis: correlation with inflammatory mediators.

Crit Care Med 2007; 35:199-206. Erratum in: Crit Care Med 2007; 35: 1224.

53. Vogiatzis I, Zakynthinos S, Georgiadou O, Golemati S, Pedotti A, Macklem P, Roussos C,

Aliverti A.

Oxygen kinetics and debt during recovery from expiratory flow-limited exercise in healthy

humans.

Eur J Appl Physiol 2007; 99: 265-274.

54. Vogiatzis I, Georgiadou O, Koskolou M, Athanasopoulos D, Kostikas K, Golemati S, Wagner H,

Roussos C, Wagner P, Zakynthinos S.

Effects of hypoxia on diaphragmatic fatigue in highly trained athletes.

J Physiol (London) 2007; 15: 299-308.

55. Mentzelopoulos SD, Pratikaki M, Platsouka E, Kraniotaki H, Zervakis D, Koutsoukou A,

Nanas S, Paniara O, Roussos C, Giamarellos-Bourboulis E, Routsi C, Zakynthinos S.

Prolonged use of carbapenems and colistin predisposes to ventilator-associated pneumonia by

pandrug-resistant Pseudomonas aeruginosa.

Intensive Care Med 2007; 33: 1524-1532.

56. Koutsourelakis I, Georgoulopoulos G, Perraki E, Vagiakis E, Roussos C, Zakynthinos S.*

Randomized trial of nasal surgery for fixed nasal obstruction in obstructive sleep apnoea.

Eur Respir J 2008; 31: 110-117.

57. Stratakos G, Porfyridis I, Papas V, Kandaraki C, Zissis C, Mariatou V, Liapikou A, Roussos

C, Zakynthinos S.

Exclusive diagnostic contribution of the histology specimens obtained by 19-gauge TBNA

needle in suspected malignant intrathoracic lymphadenopathy.

Chest. 2008; 133: 131-136.

10

58. Guenette JA, Vogiatzis I, Zakynthinos S, Athanasopoulos D, Koskolou M, Golemati S,

Vasilopolou M, Wagner HE, Roussos C, Wagner PD, Boushel R.

Human respiratory muscle blood flow measured by near-infrared spectroscopy and

indocyanine green.

J Appl Physiol 2008; 104:1202-1210.

Editorial: Kuebler W. How NIR is the future in blood flow monitoring? J Appl Physiol 2008; 104:

905-906.

59. Vogiatzis I, Stratakos G , Athanasopoulos D, Georgiadou O, Golemati S, Koutsoukou A,

Weisman I, Roussos C, Zakynthinos S.

Chest wall volume regulation during exercise in COPD patients with GOLD stages II to IV.

Eur Respir J 2008; 32: 42-52.

60. Vogiatzis I, Zakynthinos S,* Boushel R, Athanasopoulos D, Guenette JA, Wagner HE, Roussos

C, Wagner P.

The contribution of intrapulmonary shunts to the alveolar to arterial oxygen difference during

exercise is very small.

J Physiol (London) 2008; 586: 2381-2391.

61. Koutsourelakis I, Perraki E, Bonakis A, Vagiakis E, Roussos C, Zakynthinos S.*

Determinants of subjective sleepiness in suspected obstructive sleep apnoea.

J Sleep Res 2008; 17: 437-443.

62. Vogiatzis I, Athanasopoulos D, Stratakos G , Garagouni C, Koutsoukou A, Boushel R, Roussos C,

Zakynthinos S.

Exercise-induced skeletal muscle deoxygenation in O2-supplemented COPD patients.

Scand J Med Sci Sports 2009; 19: 364-372.

63. Metzelopoulos S, Zakynthinos S, Tzoufi M, Katsios N, Papastylianou A, Gkizioti S,

Stathopoulos A, Killintza A, Stamataki E, Roussos C.

Vasopressin, epinephrine, and corticosteroids for inhospital cardiac arrest.

Arch Internal Med 2009; 169: 15-24.

64. Vogiatzis I, Athanasopoulos D, Boushel R, Guenette J, Maria Koskolou, Vasilopoulou M, Wagner

H, Roussos C, Wagner P, Zakynthinos S.

Contribution of respiratory muscle blood flow to exercise-induced diaphragmatic fatigue in trained

cyclists.

J Physiol (London) 2008; 586: 5575 - 5587.

65. Stratakos G, Zuccatosta L, Porfyridis I, Sediari M, Zisis C, Mariatou V, Kostopoulos E, Psevdi A,

Zakynthinos S, Gasparini S.

Silver nitrate through flexible bronchoscope in the treatment of bronchopleural fistulae.

J Thorac Cardiovasc Surg 2009: 138: 603-607.

66. Toumpanakis D, Karatza M-H, Katsaounou P, Roussos C, Zakynthinos S, Papapetropoulos

A, Vassilakopoulos T.

Antioxidant supplementation alters cytokine production from monocytes.

J Interf Cytok Res 2009; 29: 31-38.

67. Koutsourelakis I, Perraki E, Dimitrokalli P, Economou N, Vagiakis E, Roussos C, Zakynthinos

S.

11

Predictors of residual sleepiness in adequately treated obstructive sleep apnoea patients.

Eur Respir J 2009; 34:687-693.

68. Nasis IG, Vogiatzis I, Stratakos G, Athanasopoulos D, Koutsoukou A, Daskalakis A, Spetsioti S,

Evangelodimou A, Roussos C, Zakynthinos S.

Effects of interval-load versus constant-load training on the BODE index in COPD patients.

Respir Med 2009; 103: 1392-1398.

69. Vogiatzis I, Athanasopoulos D, Habazettl H, Kuebler W, Wagner H, Roussos C, Wagner P,

Zakynthinos S.

Intercostal muscle blood flow limitation in athletes during maximal exercise.

J Physiol (London) 2009; 587:3665-3677.

Editorial (Perspective): Secher N, Richardson RS. A large slice of cardiac output or humble pie for

the respiratory muscles? J Physiol (London) 2009; 587: 3411.

70. Tsoumakidou M, Koutsopoulos AV, Tzanakis N, Dambaki K, Tzortzaki E, Zakynthinos S,

Jeffery PK, Siafakas N.

Decreased small airway and alveolar CD83+ dendritic cells in COPD.

Chest 2009; 136:726-733.

71. Tsoumakidou M, Karagiannis KP, Bouloukaki I, Zakynthinos S, Tzanakis N, Siafakas NM.

Increased bronchoalveolar lavage fluid CD1c expressing dendritic cells in idiopathic pulmonary

fibrosis.

Respiration 2009; 78: 446-452.

72. Tsoumakidou M, Bouloukaki I, Koutala H, Kouvidi K, Mitrouska I, Zakynthinos S, Tzanakis N,

Jeffery PK, Siafakas NM.

Decreased sputum mature dendritic cells in healthy smokers and patients with chronic obstructive

pulmonary disease.

Int Arch Allergy Immunol 2009; 150: 389-397.

73. Vogiatzis I, Simoes D, Stratakos G, Kourepini E, Terzis G, Manta P, Athanasopoulos D, Roussos

C, Wagner P, Zakynthinos S.

Effect of pulmonary rehabilitation on muscle remodelling in cachectic patients with COPD.

Eur Respir J. 2010; 36: 301-310.

74. Habazettl H, Athanasopoulos D, Kuebler W, Wagner H, Roussos C, Wagner P, Ungruhe J,

Zakynthinos S, Vogiatzis I.

Near-infrared spectroscopy and indocyanine green derived blood flow index for non-invasive

measurement of muscle perfusion during exercise.

J Appl Physiol. 2010; 108: 962-967.

75. Metzelopoulos S, Malachias S, Κokkoris S, Roussos C, Zakynthinos S.

Comparison of high-frequency oscillation and tracheal gas insufflation versus standard high-

frequency oscillation at two levels of tracheal pressure.

Intensive Care Med. 2010; 36:810-816.

76. Vogiatzis I, Athanasopoulos D, Habazettl H, Aliverti A, Louvaris Z, Herouvim E, Wagner H,

Roussos C, Wagner P, Zakynthinos S.

Intercostal muscle blood flow limitation during exercise in chronic obstructive pulmonary disease.

Am J Respir Crit Care Med 2010; 182: 1105-1113.

12

77. Athanasopoulos D, Louvaris Z, Herouvim E, Andrianopoulos V, Roussos C, Zakynthinos S,

Vogiatzis I.

Expiratory muscle loading increases intercostal muscle blood flow during leg exercise in healthy

humans.

J Appl Physiol. 2010; 109: 388-395.

78. Koutsourelakis I, Perraki E, Dimitrokalli P, Economou N, Vagiakis E, Roussos C, Zakynthinos

S.

Nasal inflammation in sleep apnoea patients using CPAP and effect of heated humidification. A

randomized, sham-controlled, crossover study.

Eur Respir J 2011; 37: 587-594.

Selected by the European Lung Foundation (ELF), which is the public voice of the European

Respiratory Sosciety, providing respiratory information to the general public and patients across

Europe, for the ELF website in March e-newsletter in the section called “Science update”. One

article is selected for presentation and analysis per month.

79. Doris K, Karabela SP, Kairi CA, Simoes DC, Roussos C, Zakynthinos S, Kalomenidis I,

Blackwell TS, Stathopoulos GT.

Allergic inflammation does not impact chemical-induced carcinogenesis in the lungs of mice.

Respir Res 2010; 11: 118.

80. Routsi C, Stanopoulos I, Zakynthinos E, Politis P, Papas V, Zervakis D, Zakynthinos S.

Nitroglycerin can facilitate weaning of difficult-to-wean chronic obstructive pulmonary disease

patients: a prospective interventional non-randomized study.

Crit Care 2010; 14: R204

81. Metzelopoulos S, Malachias S, Κokkoris S, Roussos C, Zakynthinos S.

Scanographic comparison of high frequency oscillation with vs. without tracheal gas insufflation

in acute respiratory distress syndrome.

Intensive Care Med. 2010; 37:990-999.

82. Vogiatzis I, Terzis G, Stratakos G, Cherouveim E, Athanasopoulos D, Spetsioti S, Nasis I, Manta

P, Roussos C, Zakynthinos S.

Effect of pulmonary rehabilitation on peripheral muscle fiber remodelling in COPD patients with

GOLD stages II to IV.

Chest 2011; 140:744-752.

83. Vogiatzis I, Habazettl H, Aliverti A, Athanasopoulos D, Louvaris Z, LoMauro Α, Wagner H,

Roussos C, Wagner P, Zakynthinos S.*

Effect of helium breathing on intercostal and quadriceps muscle blood flow during exercise in

COPD patients.

Am J Physiol Regul Ιntegr Comp Physiol 2011; 300:R1549-1559.

84. Tsimogianni AM, Rovina N, Porfyridis I, Nikoloutsou I, Roussos C, Zakynthinos S,

Stathopoulos G.

Clinical prediction of pulmonary embolism in respiratory emergencies.

Thromb Res 2011; 127:411-417.

13

85. Vogiatzis I, Louvaris Z, Habazettl H, Athanasopoulos D, Andrianopoulos V, Cherouveim E,

Wagner H, Roussos C, Wagner P, Zakynthinos S.

Frontal cerebral cortex blood flow, oxygen delivery and oxygenation during

normoxic and hypoxic exercise in athletes.

J Physiol (London) 2011; 589:4027-4039.

Editorial (Perspective): Secher NH, Fisher JP. The brain at work. J Physiol (London) 2011;

589:4405.

86. Mentzelopoulos SD, Malachias S, Zintzaras E, Kokkoris S, Zakynthinos E, Makris D, Magira E,

Markaki V, Roussos C, Zakynthinos S.

Intermittent recruitment with high-frequency oscillation/tracheal gas insufflation in acute

respiratory distress syndrome.

Eur Respir J 2012; 39:635-647

87. Karabela S, Kairi C, Magkouta S, Psallidas I, Moschos C, Stathopoulos I, Zakynthinos S,

Roussos C, Kalomenidis I, Stathopoulos G.

Neutralization of tumor necrosis factor bioactivity ameliorates urethane-induced pulmonary

oncogenesis in mice.

Neoplasia 2011; 13:1143-1151.

88. Karabela SP, Psallidas I, Sherrill TP, Kairi CA, Zaynagetdinov R, Cheng DS, Vassiliou S,

McMahon F, Gleaves LA, Han W, Stathopoulos I, Zakynthinos SG, Yull FE, Roussos C,

Kalomenidis I, Blackwell TS, Stathopoulos GT.

Opposing effects of bortezomib-induced nuclear factor-κB inhibition on chemical lung

carcinogenesis.

Carcinogenesis 2012; 33:859-867.

89. Koutsourelakis I, Perraki E, Zakynthinos G, Minaritzoglou A, Vagiakis E, Zakynthinos S.

Clinical and polysomnographic determinants of snoring: effects of body position and sleep stage

on snoring.

J Sleep Res 2012; 33:859-867.

90. Vogiatzis I, Louvaris Z, Habazettl H, Andrianopoulos V, Wagner H, Roussos C, Wagner P,

Zakynthinos S.

Cerebral cortex oxygen delivery and exercise limitation in patients with COPD.

Eur Respir J 2013; 41:295-301.

91. Koutsourelakis I, Saffirudin F, Ravesloot M, Zakynthinos S, de Vries N.

Surgery for obstructive sleep apnea: sleep endoscopy determinants of outcome

Laryngoscope 2012; 122:2587-2591.

92. Louvaris Z, Zakynthinos S, Aliverti A, Habazettl H, Vasilopoulou M, Andrianopoulos V,

Wagner H, Wagner P, Vogiatzis I.

Heliox increases quadriceps muscle oxygen delivery during exercise in COPD patients with and

without dynamic hyperinflation.

J Appl Physiol 2012; 113:1012-1023.

93. Koutsourelakis I, A.Minaritzoglou A, Zakynthinos G, Vagiakis E, Zakynthinos S.*

The effect of nasal tramazoline with dexamethazone in obstructive sleep apnoea patients. A

randomised placebo-controlled crossover trial.

Eur Respir J 2013; 42:1055-1063.

14

94. Litsiou E, Semitekolou M, Galani IE, Morianos I, Tsoutsa A, Kara P, Rontogianni D, Bellenis

I, Konstantinou M, Potaris K, Andreakos E, Sideras P, Zakynthinos S, Tsoumakidou M.

CXCL13 production in B cells via TLR/lymphotoxin receptor signaling are involved in lymphoid

neogenesis in COPD.

Am J Respir Crit Care Med 2013; 187: 1194-1202.

Editorial: Monin L, Khader S. B cells produce CXCL13 in lymphoid neogenesis during chronic

obstructive pulmonary disease. The new kid on the block? Am J Respir Crit Care Med 2013; 187:

1162-1164.

95. Papastathi C, Mavrommatis A, Mentzelopoulos S, Konstandellou E, Alevisaki M, Zakynthinos

S.*

Insulin-like Growth Factor I and its binding protein 3 in sepsis.

Growth Horm. IGF Res. 2013; 23: 98-104.

96. Zakynthinos S*, Papanikolaou S, Mentzelopoulos S, Konstandelou E, Psachoulia C,

Mavrommatis A.

Procollagen type III aminoterminal propeptide as biomarker of host response in severe sepsis.

J Crit Care 2013; 28:577-585.

97. Vrettou C, Zakynthinos S, Malachias S, Mentzelopoulos S.

High frequency oscillation and tracheal gas insufflation in patients with severe acute respiratory

distress syndrome and traumatic brain injury: an interventional physiological study.

Crit Care 2013; 17: R136

Editorial: Pelosi P, Sutherasan Y. High-frequency oscillatory ventilation with tracheal gas

insufflation: the rescue strategy for brain-lung interaction. Crit Care 2013; 17: R179.

98. Louvaris Z, Kortianou EA, Spetsioti S, Vasilopoulou M, Nasis I, Asimakos A, Zakynthinos S,

Vogiatzis I.

Intensity of daily physical activity is associated with central hemodynamic and leg muscle oxygen

availability in COPD.

J Appl Physiol 2013; 115: 794-802.

99. Mentzelopoulos S, Malachias S, Chamos C, Konstantopoulos D, Ntaidou T, Papastylianou A,

Kolliantzaki I, Theodoridi M, Ischaki H, Makris D, Zakynthinos E, Zintzaras E, Sourlas S,

Aloizos S, Zakynthinos S.

Vasopressin, steroids, and epinephrine and neurologically favorable survival after in-hospital

cardiac arrest: a randomized clinical trial.

JAMA 2013; 310: 270-279.

Presented as summary of the study combined with comments of various experts in NATURE

REVIEWS, CARDIOLOGY as Research Highlights by Roberts A, Vol. 10, Sep. 2013.

Included among the Emergency Medicine Top Stories of 2013 (a perspective on the most

important research in the field of Emergency Medicine from the year 2013) of the NEJM Journal

Watch. Dec. 27, 2013.

Journal Club Critique: “Epinephrine, vasopressin and steroids for in-hospital cardiac arrest: the

right cocktail therapy?” by Buddineni JP, Callaway C, Huang DT. Crit Care 2014; 18: 308.

100. Gratziou C, Florou A, Ischaki E, Eleftheriou K, Sachlas A, Bersimis S, Zakynthinos S.

Smoking cessation effectiveness in smokers with COPD and asthma under real life conditions.

15

Respir Med 2014; 108: 577-583.

101. Vrettou C, Zakynthinos S, Malachias S, Mentzelopoulos S.

The effect of high-frequency oscillatory ventilation combined with tracheal gas insufflation on

extravascular lung water in patients with acute respiratory distress syndrome: A randomized,

crossover, physiologic study.

J Crit Care 2014; 29: 568-573.

102. Louvaris Z, Vogiatzis I, Aliverti A, Habazettl H, Wagner H, Wagner PD, Zakynthinos S.*

Blood flow does not redistribute from respiratory to leg muscles during exercise breathing heliox

or oxygen in COPD.

J Appl Physiol 2014; 117: 267-276.

103. Flevari A, Vagiakis E, Zakynthinos S.

Heart rate variability is augmented in patients with positional obstructive sleep apnea, but only

supine LF/HF index correlates with its severity.

Sleep Breath 2015; 19: 359-367.

104. Tsoumakidou M, Tousa S, Semitekolou M, Panagiotou P, Panagiotou A, Morianos I, Litsiou

E, Trochoutsou AI, Konstantinou M, Potaris K, Footitt J, Mallia P, Zakynthinos S, Johnston

SL, Xanthou G.

Tolerogenic signaling by pulmonary CD1c+ dendritic cells induces regulatory T cells in patients

with chronic obstructive pulmonary disease by IL-27/IL-10/inducible costimulator ligand.

J Allergy Clin Immunol 2014; 134: 944-954.

105. Koutsourelakis I, Koutsourelakis Ι, Keliris A, Minaritzoglou A, Zakynthinos S.*

Nasal steroids in snorers can decrease snoring frequency. A randomized placebo-controlled

crossover trial.

J Sleep Res 2015; 24: 160-166.

106. Kortianou E, Aliverti A, Louvaris Z, Vasilopoulou M, Nasis I, Asimakos A, Zakynthinos S,

Vogiatzis I.

Limitation in tidal volume expansion partially determines the intensity of physical activity in

COPD.

J Appl Physiol 2015; 118: 107-114.

107. Vogiatzis I, Habazettl H, Louvaris Z, Andrianopoulos V, Wagner H, Zakynthinos S, Wagner P.

A method for assessing heterogeneity of blood flow and metabolism in exercising normal human

muscle by near infrared spectroscopy.

J Appl Physiol 2015; 118: 783-793.

108. Manitsopoulos N, Orfanos S, Kotanidou A, Nikitopoulou I, Siempos I, Magkou C, Dimopoulou I,

Zakynthinos S, Armaganidis A, Maniatis N.

Inhibition of HMGCoA reductase by simvastatin protects mice from injurious mechanical

ventilation.

Respir Res 2015; 16: 24.

109. Nasis I, Kortianou E, Vasilopoulou Μ, Spetsioti S, Louvaris Z, Kaltsakas G, Davos CH,

Zakynthinos S, Koulouris NG, Vogiatzis I.

Hemodynamic effects of high intensity interval training in COPD patients exhibiting exercise-

induced dynamic hyperinflation.

Respir Physiol Neurobiol 2015; 217: 8-16.

16

110. Giannakaki S, Politi L, Antonogiannaki EM, Spanakis N, Arsenis G, Filaditaki V, Zakynthinos

S, Karagiannidis N, Tsakris A.

Absence of human rhinovirus and respiratory syncytial virus from bronchoalveolar lavage and

bronchial biopsies of selected patients with stable chronic obstructive pulmonary disease.

Respir Res 2016; 17: 11.

111. Stratakos G, Gerovasili V, Dimitropoulos C, Giozos I, Filippidis FT, Gennimata S,

Zarogoulidis P, Zissimopoulos A, Pataka A, Koufos N, Zakynthinos S, Syrigos K,

Koulouris N.

Survival and quality of life benefit after endoscopic management of malignant central airway

obstruction.

J Cancer 2016; 7: 794-802.

112. Bibli SI, Andreadou I, Glynos C, Chatzianastasiou A, Toumpanakis D, Zakynthinos S,

Vasilakopoulos T, Iliodromitis EK, Papapetropoulos A.

Exposure to cigarette smoke abrogates the beneficial effect of ischemic postconditioning.

Am J Physiol Heart Circ Physiol 2016; 31: H1321-H1332.

113. Vakali S, Vogiatzis I, Florou A, Giavi S, Zakynthinos S, Papadopoulos NG, Gratziou C.

Exercice-induced bronchoconstriction among athletes: Assessment of bronchial provocation tests.

Respir Physiol Neurobiol 2017; 235: 34-39.

114. Louvaris Z, Habazettl H, Asimakos A, Wagner H, Zakynthinos S, Wagner PD, Vogiatzis I.

Heterogeneity of blood flow and metabolism during exercise in patients with chronic obstructive

pulmonary disease.

Respir Physiol Neurobiol 2017; 237: 42-50.

115. Makris D, Leroy S, Pradelli J, Benzaquen J, Guenard H, Perotin JM, Zakynthinos S,

Zakynthinos E, Deslee G, Marquette CH.

Changes in dynamic lung mechanics after lung volume reduction coil treatment of severe

emphysema.

Thorax. 2018; 73: 584-586.

116. Mentzelopoulos SD, Zakynthinos S.

Research Integrity, Academic Promotion, and Attribution of Authorship and Nonauthor

Contributions.

JAMA. 2017; 318:1221-1222.

117. Louvaris Z, Habazettl H, Wagner H, Zakynthinos S, Wagner P, Vogiatzis I.

Near-infrared spectroscopy using indocyanine green dye for minimally invasive measurement of

respiratory and leg muscle blood flow in patients with COPD.

J Appl Physiol 2018; 125: 947-959.

118. Kerdidani D, Magkouta S, Chouvardas P, Karavana V, Glynos K, Roumelioti F, Zakynthinos

S, Wauters E, Janssens W, Lambrechts D, Kollias G, Tsoumakidou M.

17

Cigarette Smoke-Induced Emphysema Exhausts Early Cytotoxic CD8+ T Cell Responses against

Nascent Lung Cancer Cells.

J Immunol. 2018; 201: 1558-1569.

119. Mentzelopoulos SD, Koliantzaki I, Karvouniaris M, Vrettou C, Mongardon N, Karlis G, Makris

D, Zakynthinos E, Sourlas S, Aloizos S, Xanthos T, Zakynthinos S.

Exposure to Stress-Dose Steroids and Lethal Septic Shock After In-Hospital Cardiac Arrest:

Individual Patient Data Reanalysis of Two Prior Randomized Clinical Trials that Evaluated

the Vasopressin-Steroids-Epinephrine Combination Versus Epinephrine Alone.

Cardiovasc Drugs Ther. 2018; 32: 339-351.

(Publisher correction: Cardiovasc Drugs Ther 2018; 32: 639-641)

120. Glynos C, Bibli SI, Katsaounou P, Pavlidou A, Magkou C, Karavana V, Topouzis S,

Kalomenidis I, Zakynthinos S, Papapetropoulos A.

Comparison of the effects of e-cigarette vapor with cigarette smoke on lung function and

inflammation in mice.

Am J Physiol Lung Cell Mol Physiol 2018; 315: L662-L672.

(has been selected for APSselect (http://apsselect.physiology.org/), a collection from the APS

that showcases some of the best recently published articles in physiological research; an ward

certificate was attached)

121. Mentzelopoulos SD, Anninos H, Malachias S, Zakynthinos S.

"Low-" versus "high"-frequency oscillation and right ventricular function in ARDS. A

randomized crossover study.

J Intensive Care 2018; 6: 58.

122. Louvaris Z, Spetsioti S, Andrianopoulos V, Chynkiamis N, Habazettl H, Wagner H,

Zakynthinos S, Wagner PD, Vogiatzis I.

Cardiac output measurement during exercise in COPD: A comparison of dye dilution and

impedance cardiography.

Clin Respir J. 2019; 13: 222-231.

123. Kerdidani D, Chouvardas P, Arjo AR, Giopanou I, Ntaliarda G, Guo YA, Tsikitis M,

Kazamias G, Potaris K, Stathopoulos GT, Zakynthinos S, Kalomenidis I, Soumelis V,

Kollias G, Tsoumakidou M.

Wnt1 silences chemokine genes in dendritic cells and induces adaptive immune resistance in

lung adenocarcinoma.

Nat Commun. 2019 Mar 29;10(1):1405.

Β. CASE REPORTS/STUDIES (Peer Review, Indexed in Pubmed)

124. Zakynthinos E, Vassilakopoulos T, Roussos C, Zakynthinos S.

18

Abnormal atrial and ventricular repolarisation resembling myocardial injury after tricyclic

antidepressant drug intoxication.

Heart 2000; 83:353-354.

125. Zakynthinos E, Vassilakopoulos T, Mpetsou A, Malagari E, Roussos C, Zakynthinos S.

Fever in patients with pacemaker: The necessity of performing transesophageal echcardiography early.

Intensive Care Med 2000; 26:1157-1161.

126. Zakynthinos E, Vassilakopoulos T, Kontogianni D, Roussos C, Zakynthinos S.

A role of transesophageal echocardiography in the early diagnosis of catastrophic antiphospholipid

syndrome.

J Ιnternal Μedicine 2000; 248: 519-524.

127. Zakynthinos E,Vassilakopoulos T,Kaltsas P,Malagari E,Daniil Z,Roussos C,Zakynthinos S.*

Pulmonary hypertension, interstitial lung fibrosis, and lung iron deposition in thalassaemia major.

Thorax 2001; 56: 737-739.

128. Zakynthinos E, Vassilakopoulos T, Politis P, Daniil Z, Roussos C, Zakynthinos S.

Uremic pericarditis with tamponade following prolonged continuous hemofiltration.

Intensive Care Med 2001; 27: 1958-1959.

129. Zakynthinos E, Vassilakopoulos T, Routsi C, Roussos C, Zakynthinos S.

Early- and late-onset atrioventricular valve rupture after blunt chest trauma : The usefulness of

transesophageal echocardiography.

J Trauma 2002; 52: 990-996.

130. Gavala A, Klimopoulos S, Exarchos D, Konstantinidis K, Daniil Z, Zakynthinos S, Zakynthinos

E.

Persistent primary peritonitis due to Group A streptococcus and E-coli.

Intensive Care Med 2002; 28: 1829-1831.

131. Zakynthinos E, Douka E, Daniil Z, Konstantinidis K, Markaki V, Zakynthinos S.

Anuria due to acute bilateral renal vein occlusion after thrombolysis for pulmonary embolism.

Int J Cardiol. 2005; 101: 163-166.

132. Stratakos G, Kalomenidis I, Papas V, Malagari K, Kollintza A, Roussos C, Anagnostopoulou M,

Paniara O, Zakynthinos S, Papiris SA.

Cough and fever in a female with Crohn's disease receiving infliximab.

Eur Respir J 2005; 26: 354-357.

#133. Stratakos G, Zisis C, Bellenis I, Filaditaki V, Liapikou A, Zakynthinos S, Roussos C.

Tracheoesophageal fistula managed with tracheal stent through flexible bronchoscopy without

fluoroscopy.

Monaldi Arch Chest Dis 2006; 65:225-227.

134. Porfyridis I, Zisis C, Glinos K, Stavrakaki K, Rontogianni D, Zakynthinos S, Roussos C,

Stratakos G.

Recurrent cough and hemoptysis associated with tracheal capillary hemangioma in an

adolescent boy: a case report.

J Thorac Cardiovasc Surg 2007; 134:1366-1367.

#135. Koutsourelakis, I., Perraki, E., Dimitrokali, P., Kalliou, V., Tsolia, M., Vagiakis, E., Roussos,

C., Zakynthinos S.

19

Severe obstructive sleep apnoea syndrome in a 5-year-old girl.

Intern J Pediatric Otorhinol Extra 2007; 2: 147-150.

#136. Vagiakis E, Koutsourelakis I, Perraki E, Roussos C, Mastora Z, Zakynthinos S, Kotanidou A.

Average volume-assured pressure support in a 16-year-old girl with congenital central

hypoventilation syndrome.

J Clin Sleep Med. 2010; 6: 609-612.

#137. Tsimogianni A, Stratiki M, Stratakos G, Zakynthinos S, Katsaounou P.

Pulmonary fibrosis predating microscopic polyangiitis by seven years.

Respiratory Medicine CME 2010; 3: 207–210.

138. Stratiki M, Gianniou N, Zakynthinos S, Stathopoulos GT.

Pulmonary embolism detected on unenhanced chest computed tomography.

Am J Respir Crit Care Med 2012; 185(11):e15.

139. Magira E, Pitsolis T, Delimpasi S, Vourlakou C, Vlachoyiannopoulos P, Zakynthinos S.

Virus infection and autoimmunity: Is there a cause-and-effect relationship?

J Clin Virol 2014; 59: 137-140.

#140. Sotiriou A, Ververaki S, Chalkis A, Riga D, Zakynthinos S.

Acute hemorrhagic leukoencephalitis: multimodal diagnosis and treatment.

Hospital Chronicles 2014; 9: 195–200.

#141. Asimakos A, Anninos H, Papastamopoulos V, Mentzelopoulos S, Zakynthinos S.

Pulmonary hypertention due to chronic thromboembolic disease complicated with hemoptysis

and infection.

Hospital Chronicles 2015; 10: 107–111.

142. Celiac Artery Avulsion Secondary to Blunt Trauma: A Case Report.

Megalou A, Pantazopoulos IN, Antonopoulos CN, Argiriou M, Zakynthinos S, Mastora Z.

Ann Vasc Surg. 2017;43:314.e13-314.

C. REVIEWS (Peer Review, Indexed in Pubmed)

143. Roussos C, Zakynthinos S.

Fatigue of the respiratory muscles.

Intensive Care Med 1996;22:134-155.

144. Vassilakopoulos T, Zakynthinos S,* Roussos C.

Respiratory muscles and weaning failure.

Eur Respir J 1996;9:2383-2400.

#145. Vassilakopoulos T, Zakynthinos S, Roussos C.

Respiratory muscles and ventilatory failure.

Monaldi Arch Chest Dis 1996;6:489-498.

#146. Vassilakopoulos T, Zakynthinos S, Roussos C.

Factors determining the weaning outcome.

Monaldi Arch Chest Dis 1998; 53(3): 365-371.

147. Vassilakopoulos T, Roussos C, Zakynthinos S.*

20

Weaning from mechanical ventilation.

J Crit Care 1999;14: 39-62.

#148. Vassilakopoulos T, Zakynthinos E, Roussos C, Zakynthinos S.

Respiratory muscles in heart failure.

Monaldi Arch Chest Dis 1999; 54(2): 150-153.

#149. Zakynthinos S,* Vassilakopoulos T.

Intensive and high-dependency care medicine in Greece.

Monaldi Arch Chest Dis 1999; 54(5): 438-440.

150. Vassilakopoulos T, Zakynthinos E, Roussos C, Zakynthinos S.

Respiratory muscle / circulation interaction in congestive heart failure.

Anasth Intensivmed 2000; 37: 352-360.

151. Vassilakopoulos T, Roussos C, Zakynthinos S.

The immune response to resistive breathing.

Eur Respir J 2004; 24 : 1033-1043.

152. Vassilakopoulos T, Roussos C, Zakynthinos S.

Is loaded breathing an inflammatory stimulus ?

Curr Opinion Crit Care 2005; 11: 1-9.

153. Vassilakopoulos T, Zakynthinos S, Roussos C.

Weaning failure: should we rest the respiratory muscles with controlled mechanical ventilation

(CMV)?

Critical Care 2005; 10: 204.

154. Mentzelopoulos S, Zakynthinos S, Siempos I, Malachias S, Ulmer H, Wenzel V.

Vasopressin for cardiac arrest: Meta-analysis of randomized controlled trials.

Resuscitation 2012; 83:32-39.

155. Vogiatzis I, Zakynthinos S.

Factors limiting exercise tolerance in Chronic Lung Diseases.

(Invited review by the American Physiological Society)

Comprehensive Physiology 2012; 2:1779–1817.

156. Vogiatzis I, Zakynthinos S.

The physiological basis of rehabilitation in Chronic Heart and Lung Disease.

J Appl Physiol. 2013; 115: 16-21.

157. Karamanou M, Zakynthinos S, Androutsos G.

The study of allergic asthma at the beginning of the 20th century: Fernand Widal (1862-

1929) and Étienne Brissaud (1882-1951).

Rev Pneumol Clin 2016; 72: 213-214 (French)

158. Magira EE, Zakynthinos S.

Legionnaire's Disease and Influenza.

Infect Dis Clin North Am 2017; 31: 137-153.

21

159. Rossi A, Butorac-Petanjek B, Chilosi M, Cosío BG, Flezar M, Koulouris N, Marin J,

Miculinic N, Polese G, Samaržija M, Skrgat S, Vassilakopoulos T, Vukić-Dugac A,

Zakynthinos S, Miravitlles M.

Chronic obstructive pulmonary disease with mild airflow limitation: current knowledge and

proposal for future research - a consensus document from six scientific societies.

Int J Chron Obstruct Pulmon Dis. 2017; 12: 2593-2610.

160. Ischaki E, Pantazopoulos I, Zakynthinos S.

Nasal high flow therapy: a novel treatment rather than a more expensive oxygen device.

Eur Respir Rev. 2017; 26 (145).

161. Routsi C, Stanopoulos I, Kokkoris S, Sideris A, Zakynthinos S.

Weaning failure of cardiovascular origin: how to suspect, detect and treat-a review of the

literature.

Ann Intensive Care 2019; 9: 6.

D. EDITORIALS OR COMMENTARIES (Peer Review, Indexed in Pubmed)

162. Zakynthinos S, Roussos C.

Hypercapnic respiratory failure. (Editorial)

Respir Med 1993;87:409-411.

163. Stratakos G, Zakynthinos S.

Adjuvant endobronchial amphotericin B for refractory invasive pulmonary aspergillosis: evidence

is scarce but promise does exist. (Editorial)

Respiration 2007; 74: 609-610.

164. Vassilakopoulos T, Zakynthinos S.

When mechanical ventilation mimics nature. (Editorial)

Critical Care Med 2008; 36: 1009-1011.

165. Orfanos SE, Zakynthinos S.

Heart biomarkers as prognostic tools for chronic thromboembolic pulmonary hypertension: a step

forward by the fatty acid-binding protein. (Editorial)

Eur Respir J 2008; 31: 915-917.

166. Zakynthinos S,* Vogiatzis I.

The major limitation to exercise performance in COPD is inadequate energy supply to the

respiratory and locomotor muscles vs. lower limb muscle dysfunction vs. dynamic hyperinflation.

Exercise intolerance in COPD: putting the pieces of the puzzle together. (Invited commentary on

Point : Counterpoint)

J Appl Physiol. 2008; 105: 758-562.

167. Vogiatzis I, Zakynthinos S.*

Physical inactivity: common pathway to peripheral muscle weakness in chronic respiratory

diseases? (Editorial)

Eur Respir J 2009; 34: 1213-1214.

22

Ε. REVIEWS (Peer Review, Non Indexed in Pubmed)

#168. Zakynthinos S,* Armaganidis A, Roussos C.

Ventilatory failure: The role of the chest wall.

Appl Cardiopulmonary Pathophysiology 1991;86:123-134.

#169. Vassilakopoulos T, Zakynthinos S, Roussos C.

Respiratory muscle fatigue. Effects on metabolism and ventilation.

Intern J Intensive Care 1995;2:85-96.

#170. Zakynthinos S,* Roussos C.

The use of negative pressure ventilation.

Eur Respir Monοgraph 1998; 8: 246-265.

#171. Vassilakopoulos T, Zakynthinos S, Roussos C.

The conventional approach to weaning from mechanical ventilation.

Eur Respir Monοgraph 1998; 8: 266-298.

#172. Vassilakopoulos T, Zakynthinos S, Roussos C,

The immune response to resistive breathing: implications for respiratoty failure.

Clinical Intensive Care 2004 ; 15 : 131-144.

#173. Christakou A, Zakynthinos S.

The effectiveness of early mobilization in hospitalized patients with deep venous thrombosis.

Hospital Chronicles 2014; 9: 1-6.

#174. Routsi C, Papas V, Zakynthinos S.

Neurormonal and inflammatory responses during weaning trials from mechanical ventilation.

OA Critical Care (in press)

#175. Koliantzaki I, Zakynthinos S, Mentzelopoulos S.

Advances in the clinical managment of cardiac arrest.

Hospital Chronicles 2014; 9: 102-117.

#176. Ischaki E, Malachias S, Zakynthinos S.

Nasal high flow oxygen in respiratory failure.

Hospital Chronicles 2016; 11: 107-132.

F. LETTERS TO THE EDITOR (Peer Review, Indexed in Pubmed)

177. Zakynthinos S, Baltopoulos G, Roussos C.

Fat emulsion and ARDS.

Chest 1990;98:509-510.

178. Vassilakopoulos T, Zakynthinos S.

Can dynamic PEEPi be greater than static PEEPi ?

Intensive Care Med 1999; 25: 768-769.

179. Zakynthinos S, Vassilakopoulos T.

Contribution of expiratory muscle pressure to dynamic intrinsic positive end-expiratory pressure.

Am J Respir Crit Care Med 2001;163: 1278-1979.

180. Vassilakopoulos T, Roussos C, Zakynthinos S.

23

When are antioxidants effective in blunting the cytokine response to exercise ?

Med Sci Sports Exerc 2005 ; 37 : 342-343.

181. Vassilakopoulos T, Zakynthinos S, Roussos C,

The immune response to resistive breathing.

Eur Respir J 2005 ; 25 : 1129-1130.

182. Metzelopoulos S, Roussos C, Zakynthinos S.

Prone position in early and severe acute respiratory distress syndrome: a design for a definitive

randomized controlled trial.

Anesth Analg 2007; 104:466-468.

#183. Vassilakopoulos T, Roussos C, Zakynthinos S.

The mixed venous oxygen saturation response to weaning from mechanical ventilation.

Respiratory Care 2007; 52: 64-65.

184. Koutsourelakis I, Zakynthinos S.

Predicting outcome of nasal surgery in patients with obstructive sleep apnoea.

Eur Respir J 2008; 32: 246-247.

185. Zakynthinos S.

Respiratory muscle training could potentially improve exercise tolerance in hypoxia by increasing

cerebral cortex oxygen delivery.

(Invited contribution to Cross Talk opposing view: Respiratory muscle training does improve

exercise tolerance; McConnell A, J Physiol 2012; 590: 3397-3398)

J Physiol 2012 (published online Sept. 11).

186. Litsiou E, Semitekolou M, Galani IE, Morianos I, Tsoutsa A, Kara P, Rontogianni D, Bellenis

I, Konstantinou M, Potaris K, Andreakos E, Sideras P, Zakynthinos S, Tsoumakidou M.

Reply: CXCL13 in Tertiary Lymphoid Tissues: Sites of Production Are Different from Sites of

Functional Localization.

Am J Respir Crit Care Med 2014; 189: 370-371.

187. Metzelopoulos S, Vrettou C, Zakynthinos S.

Vasopressin versus terlipressin and low-dose versus high-dose steroids.

Pediatr Crit Care Med 2014; 15: 794-795.

188. Kortianou E, Aliverti A, Louvaris Z, Vasilopoulou M, Nasis I, Asimakos A, Zakynthinos S,

Vogiatzis I.

Limitation in tidal volume expansion partially determines the intensity of physical activity in

COPD (Reply to engel and vemulpad).

J Appl Physiol 2015; 118: 1087.

189. Mentzelopoulos S, Vrettou C, Zakynthinos S.

Letter by Mentzelopoulos et al Regarding Article "β-Adrenergic Receptor-Mediated Cardiac

Contractility Is Inhibited Via Vasopressin Type 1A-Receptor-Dependent Signaling".

Circulation. 2015; 132: e134.

190. Koutsourelakis I, Lamprou K, Vagiakis E, Zakynthinos S.

Resolution of apnoeas in slow wave sleep.

Sleep Breath 2016; 20: 819-820.

191. Mentzelopoulos S, Malachias S, Vrettou C, Zakynthinos S.

24

Meta-analysis of High-frequency Oscillation in Acute Respiratory Distress Syndrome and

Accuracy of Results.

Anesthesiology 2016;124: 246-247.

192. Pantazopoulos I, Zakynthinos S, Mentzelopoulos S.

Corticosteroids and inflammation after cardiac arrest.

Resuscitation 2016; 99: e7-8.

193. Mentzelopoulos SD, Mongardon N, Xanthos T, Zakynthinos S.

Possible significance of hemodynamic and immunomodulatory effects of early stress-dose steroids

in cardiac arrest.

Crit Care. 2016; 20:211.

194. Louvaris Z, Vogiatzis I, Habazettl H, Wagner H, Wagner PD, Zakynthinos S.

Improvement in respiratory muscle O2 delivery is associated with less dyspnoea during exercise

in COPD.

Clin Respir J. 2018; 12:1308-1310.

195. Mentzelopoulos SD, Zakynthinos S.

Post-cardiac arrest syndrome: pathological processes, biomarkers and vasopressor support, and

potential therapeutic targets.

Resuscitation 2017; 121: A12-A14.

196. Mentzelopoulos SD, Zakynthinos S.

Authorship Credit for Large Clinical Trials-Reply.

JAMA 2018; 319: 723-724.

197. Mentzelopoulos SD, Zakynthinos S, Nichol G.

Epinephrine in Out-of-Hospital Cardiac Arrest.

N Engl J Med. 2019; 380: 396.

198. McKinnell JA, Dwyer JP, Talbot GH, Connolly LE, Friedland I, Smith A, Jubb AM, Serio

AW, Krause KM, Daikos GL; CARE Study Group.

Plazomicin for Infections Caused by Carbapenem-Resistant Enterobacteriaceae.

N Engl J Med. 2019; 380: 791-793.

G. CONTRIBUTION IN TASK FORCES

199. Member of the Task Force producing the consensus statement of the European Respiratory Society

(ERS): Optimal assessment and management of chronic obstructive pulmonary disease (COPD).

Eur Respir J 1995;8:1398-1420. No authorship, thus not calculated in IF and CI

H. CONTRIBUTION IN MULTICENTER STUDIES

25

200. Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle and

high-income countries. International Surgical Outcomes Study group.

Br J Anaesth. 2016;117:601-609. No authorship, thus not calculated in IF and CI

201. Critical care admission following elective surgery was not associated with survival benefit:

prospective analysis of data from 27 countries.

Kahan BC, Koulenti D, Arvaniti K, Beavis V, Campbell D, Chan M, Moreno R, Pearse RM;

International Surgical Outcomes Study (ISOS) group.

Intensive Care Med. 2017;43:971-979. No authorship, thus not calculated in CI and IF

202. Abbott TEF, Ahmad T, Phull MK, Fowler AJ, Hewson R, Biccard BM, Chew MS, Gillies M,

Pearse RM; International Surgical Outcomes Study (ISOS) group.

The surgical safety checklist and patient outcomes after surgery: a prospective observational

cohort study, systematic review and meta-analysis.

Br J Anaesth. 2018; 120: 146-155. No authorship, thus not calculated in CI and IF

203. International Surgical Outcomes Study (ISOS) group.

Prospective observational cohort study on grading the severity of postoperative complications

in global surgery research.

Br J Surg. 2019; 106: e73-e80. No authorship, thus not calculated in CI and IF

I. BOOK CHAPTERS IN ENGLISH

204. Zakynthinos S, Roussos C.

Mechanical ventilation in shock. Recent Advances in APICE, 1989, pp.331-337.

205. Zakynthinos S, Roussos C.

Oxygen cost of breathing. In: Tissue Oxygen Utilization. Update in Intensive Care and

Emergency Medicine. Gutierrez G, Vincent JL (eds), Springer-Verlag, Berlin. 1991, pp.171-184.

206. Roussos C, Zakynthinos S.

Ventilatory muscle fatigue and failure. In: Ventilatory Failure. Update in Intensive Care and

Emergency Medicine. Marini JJ, Roussos Ch (eds), Springer-Verlag, Berlin, 1991. pp.125-152.

207. Roussos C, Zakynthinos S.

Respiratory muscle energetics. In: The Thorax, 2nd ed. Roussos Ch (ed), Marcel Dekker Inc,

1995. pp.681-749.

208. Roussos C, Zakynthinos S.

Ventilatory failure and respiratory muscles. In: The Thorax, 2nd ed. Roussos Ch (ed), Marcel

Dekker Inc, New York, 1995. pp.2071-2099.

209. Zakynthinos S, Roussos C.

Respiratory muscles: Fatigue. In: Acute Respiratory Failure in Chronic Obstructive Pulmonary

Disease. Derenne JP, Whitelaw W, Similowski T (eds), Marcel Dekker Inc, New York, 1996.

pp.79-127.

26

210. Vassilakopoulos T, Zakynthinos S, Roussos C.

Weaning from ventilators. In: Current practice in critical illness. D Ryan (ed), Chapman and

Hall,1996, pp 152-192.

211. Vassilakopoulos T, Zakynthinos S, Roussos C.

Muscle function: Basic concepts. In: Physiologic basis of ventilator support. Marini JJ, Slutsky A

(eds), Marcel Dekker, New York, 1998. pp 103-152.

212. Vassilakopoulos T, Zakynthinos S, Roussos C.

Respiratory muscle fatigue in COPD patients. In: Anaesthesia, Pain, Intensive Care and

Emergency Medicine (APICE). Gullo A (ed), Springer - Verlag, Milano 1997, pp. 91-98.

213. Vassilakopoulos T, Zakynthinos S, Roussos C.

The pathophysiology of weaning failure. In: Yearbook of Intensive Care and Emergency

Medicine. Vincent JL (ed), Springer - Verlang, Berlin, 1998, pp. 489-501.

214. Vassilakopoulos T, Roussos C, Zakynthinos S.

Interaction of respiratory muscles and circulation in heart failure. In: Yearbook of Intensive Care

and Emergency Medicine. Vincent JL (ed), Springer - Verlang, Berlin, 1999, pp. 298-308.

215. Zakynthinos S, Roussos C.

Respiratory intensive care. In: Respiratory Medicine, 3rd ed. Gibson J et al (eds), Saunders

(Elsevier Science), London, 2003, pp. 522-540.

216. Zakynthinos S, Roussos C.

Respiratory muscle fatigue. In : Physiologic Basis of Respiratory Disease, 1st ed. Hamid Q et al

(eds), BC Decker, Hamilton, 2005, pp. 289-307.

217. Zakynthinos S, Koulouris N, Roussos C.

Respiratory mechanics and energetics. In: Murray and Nadel’s Textbook of Respiratory Medicine

, 4st ed. Mason et al (eds), Elsevier Science, Philadelphia, 2005, pp 87-135.

218. Metzelopoulos S, Roussos C, Zakynthinos S.

High frequency oscillation for acute respiratory failure in adults. In: Yearbook of Intensive Care

and Emergency Medicine. Vincent JL (ed), Springer, Berlin, 2008, pp. 290-300.

219. Ayas N, Zakynthinos S, Roussos C, Pare P.

Respiratory system mechanics and energetics. In: Murray and Nadel’s Textbook of Respiratory

Medicine , 5st ed. Mason et al (eds), Elsevier Science, Philadelphia, 2010, pp 89-107.

220. Metzelopoulos S, Zakynthinos S.

Pressure volume curves and body posture in acute respiratory failure. In: Yearbook of respiratory

care clinics and applied technologies. Esquinas A (ed), Tipografía San Francisco S.A., Murcia

Spain, 2008, pp. 309-314.

221. Koliantzaki I, Zakynthinos S, Metzelopoulos S.

The potential contribution of corticosteroids to positive cardiac arrest outcome. In: Resuscitation.

Gullo A and (eds), Springer, Berlin, 2013, pp. 143-155.

222. Louvaris Z, Zakynthinos S, Vogiatzis I.

Respiratory muscle blood flow measured by Near-Infrared Spectroscopy (NIRS) and Indocyanine

Green Dye (ICG). In: Mechanics of Breathing. New insights from new technologies. Aliverti A

and Pedotti A (eds), Springer, Milan, 2014, pp.

27

J. PROCEEDINGS IN CONGRESSES

223. Baltopoulos G, Salesiotou V, Romana K, Zakynthinos S, Patsigavdaki E, Anagnostou-Kakara E,

Roussos C.

Ammonia serum levels in post head trauma. In: Intensive and Critical Care Medicine. Aochi O,

Amaha K, Takeshita H (eds), Elsevier Science Publishers BV, Amsterdam. 1990, pp.667-668.

224. Baltopoulos G, Zakynthinos S, Baltas D, Roussos C, Papantonatos D.

Improvement of O2 uptake after hypertonic solution administration in refractory shock states. In:

Intensive and Critical Care Medicine. Aochi O, Amaha K, Takeshita H (eds), Elsevier Science

Publishers BV, Amsterdam. 1990, pp.1057-1058.

225. Vassilakopoulos T, Zakynthinos S, Roussos C.

The role of the respiratory muscles in weaning failure. In: Proceedings of the 8th European

Congress of Intensive Care Medicine. Roussos Ch (ed), Monduzzi Editore, Bologna, Italy. 1995,

pp.387-392.

28

IMPACT FACTOR AND CITATION INDEX

Total Impact Factor : 1354,84

Impact Factor of Original Articles : 836,24

Impact Factor of Original Articles/Reviews/Editorials : 1082,38

Impact Factor of Original Articles as First, Second or Senior author : 704,59

Mean Total Impact Factor (Total Impact Factor / Number of Publications) : 6,67

Mean Impact Factor of Original Articles : 6,80

Mean Impact Factor of Original Articles/Reviews/Editorials : 6,85

Total Citation Index : 6712 [6712 (GoogleSholar), 4541 (Scopus)]

Citation Index of Original Articles : 5214

Citation Index of Original Articles/Reviews/Editorials : 5424

Citation Index of Original Articles as First, Second or Senior author : 3910

h-Index: 45 [45 (GoogleSholar), 38 (Scopus)]