project feasibility report -...
TRANSCRIPT
PROJECT FEASIBILITY
REPORT
FOR OBTAINING
PRIOR ENVIRONMENT CLEARANCE
FOR
EXPANSION
IN THE EXISTING SET UP
OF
M/s. BCJ PHARMA LLP
LOCATED AT:
Plot No.: 7102, Road No. 71, Sachin-GIDC, Sachin, Tal.: Choryasi, Dist.: Surat, State: Gujarat.
PRE-FEASIBILITY REPORT M/s. BCJ PHARMA LLP
[2]
1. EXECUTIVE SUMMARY
M/s. BCJ PHARMA LLP is new unit located at Plot No.: 7102, Road No. 71, Sachin-GIDC, Sachin, Tal.:
Choryasi, Dist.: Surat, State: Gujarat. will involve to manufacture of drugs.
Project is located within GIDC area. The unit is going for production of synthetic organic chemicals. Therefore,
project falls under category B of schedule 5(f), as per the EIA Notification, September 2006. Therefore, it requires
prior Environment Clearance.
There shall be no forest, wild life sanctuary, eco sensitive area present within 10 km area from the project site.
Electric power requirement for proposed project will be 1000 KVA, which will be procured from DGVCL.
One Boiler of Capacity 1 TPH and One Thermo pack of capacity 4 TPH will be installed. Imported Coal will be used
as a fuel in Boiler and Thermopack. Therefore, Multi Cyclone Separator and Bag Filter & water scrubber will be
installed as Air Pollution Control System. Water scrubber followed by alkali scrubber and Ammonia Recovery
System will be attached with Reaction vessel as Air Pollution Control System.
For proposed project activity, water required for domestic & industrial purpose will be sourced from GIDC.
Domestic effluent shall be disposed in to Septic tank / Soak pit system. Industrial waste water after primary
Treatment in to ETP and confirming to the CETP inlet norms shall be disposed to CETP for its further treatment
and final disposal.
Hazardous/solid waste generated from the process and other industrial activity will be stored in a separate
hazardous waste storage area and then it will be disposed at nearest TSDF site for secured land filling. Unit will get
TSDF membership after getting EC but before starting of production.
Proper safety will be provided during storage, handling and use of hazardous substance. Portable Fire
Extinguishers shall be provided at key location.
Total area of project site is 1295.00 m2. Approx. 155.00 m2 (Outside of premises) area will be developed as a
green belt.
Due to proposed project, total employment generation will be 32 (30 men + 2 women).
PRE-FEASIBILITY REPORT M/s. BCJ PHARMA LLP
[3]
2. INTRODUCTION OF PROJECT / BACKGROUND INFORMATION
2.1 IDENTIFICATION OF PROJECT AND PROJECT PROPONENT
M/s. BCJ PHARMA LLP is new unit located at Plot No.: 7102, Road No. 71, Sachin-GIDC, Sachin, Tal.:
Choryasi, Dist.: Surat, State: Gujarat. and manufacturing of Drugs.
PROJECT PROPONENT
M/s. BCJ PHARMA LLP is a Partnership firm. Mr. Pragnesh Thummar is a Managing Director of the
company.
2.2 NATURE OF THE PROJECT
M/s. BCJ PHARMA LLP is a small scale unit. It covers under the category 5(f) of synthetic organic
chemical industry.
2.3 NEED FOR THE PROJECT
M/s. BCJ PHARMA LLP will engage in production of Drugs. Due to need of intermediate products in market, unit proposes to produce product intermediate products.
2.4 EMPLOYMENT GENERATION (DIRECT & INDIRECT) DUE TO THE PROJECT
Due to proposed project, employment will be generated. The unit will hire local people from the nearby villages.
Due to proposed project, approx. 32 people (30 men + 2 women) will be required. Therefore, Total employment from this project will be 32 (30 men + 2 women).
PRE-FEASIBILITY REPORT M/s. BCJ PHARMA LLP
[4]
3. PROJECT DESCRIPTION
3.1 TYPE OF PROJECT
The unit will involve in manufacturing of Drugs.
3.2 LOCATION
The site is located at about 21° 5'39.45"N latitude and 72°51'33.39"E longitude.
LOCATION OF THE PROJECT
3.3 DETAILS OF ALTERNATE SITES
No alternative sites examined as proposed project is located within GIDC area
PRE-FEASIBILITY REPORT M/s. BCJ PHARMA LLP
[5]
3.4 DETAILS RAW MATERIAL AND PRODUCT
3.4.1 LIST OF PRODUCT
Sr. No.
Name Of Product Capacity (MT/Month)
Chemical Formula
Therapeutic use
1. Albendazole and/or 35 C12H15N3O2S Antihelmintics
2. Alendronate Sodium and/or 1 C4H13NO7P2 Bone Enhancers
3. Amisulpride and/or 4 C17H27N3O4S Psychotherapeutics 4. Duloxetine HCl and/or 1.5 C18H19NOS.HCL
5. Bisoprolol and/or 1.1 C18H31NO4
Anti hypertensive
6. Lacidipine Hydrochloride and/or 0.8 C26H33NO6
7. Losartan Potassium and/or 3 C22H23ClN6O
8. Nisoldipine and/or 1 C20H24N2O6
9. Olmesartan and/or 1.5 C29H30N6O6
10. Telmisartan and/or 3.5 C33H30N4O2
11. Dutasteride and/or 0.5 C27H30F6N2O2 BPH Agents
12. Tamsulosine HCl and/or 1.1 C20H28N2O5S
13. Fexofenadine Hydrochloride and/or 6 C32H39NO4. HCL Antihistamine
14. Loratidine and/or 3.5 C22H23ClN2O2
15. Gabapentin and/or 3 C9H17NO2 Anticonvulsants
16. Pregabalin and/or 4 C8H17NO2
17. Glimepiride and/or 1 C24H34N4O5S Antidiabetic agent
18. Larnoxicam and/or 2.5 C13H10ClN3O4S2 Anti-inflammatory
19. Lansoprazole and/or 3 C16H14F3N3O2S
Antiulcers 20. Omeprazole and/or 6 C17H19N3O3S
21. Pantoprazole Sodium and/or 8 C16H15F2N3O4S
22. Rabeprazole Sodium and/or 3 C18H21N3O3S
23. Phenylephrine Hydrochloride and/or
4 C9H13NO2
Decongestants
24. Prilocaine HCl and/or 0.5 C13H20N2O Anesthetic
25. Sertraline Hydrochloride and/or 1 C17H17Cl2N antidepressant
26. Simvastatin and/or 0.5 C25H38O5 Antilipemics
Note: The unit will produce any of the above Products individually / simultaneously having total production capacity shall not exceed 100 MT/Month.
3.4.2 LIST OF RAW MATERIALS
Sr. No.
Products Raw Material
Molecular formula Raw Material Consumption
Kg/Batch MT/Month
1. Albendazole
2-Nitro-4-thiocyano aniline C7H5N3O2S 420 26.72
n-Propanol C3H8O 1850 117.72
n-Propyl Bromide C3H7Br 180 11.45
Sodium Hydrosulphide NaHS 1720 109.45
Thiourea CH4N2S 239 15.20
Dimethyl Sulphate (CH3)2SO4 216 13.74
PRE-FEASIBILITY REPORT M/s. BCJ PHARMA LLP
[6]
Methyl Chloroformate ClCOOCH3 600 38.18
Sodium Hydroxide NaOH 835 53.13
Acetic Acid C2H4O2 195 12.40
Water H2O 550 35.0
DM water H2O 50 3.18
and/or
2. Alendronate Sodium
2-Pyrrolidinone C4H7NO 35.03 0.34
DM Water H2O 608.54 5.92
Methane sulphonic acid CH4O3S 248.70 2.42
Phosphorus Trichloride PCl3 69.30 0.67
Activated carbon C 0.75 0.0072
Hyflow (Celite) O2Si 5.0 0.048
Sodium Hydroxide NaOH 50.15 0.487
and/or
3. Amisulpride
AMT-III (4-amino-2- methoxy-5-ethyl thiomethoxy benzoate)
C10H11O3NS 243.99 9.76
Sodium hydroxide NaOH 265.01 10.60
Conc. Hydrochloric acid HCl 24.39 0.975
Water H2O 1189.6 47.58
Propanol C3H8O 220.77 8.83
Hydrogen peroxide H2O2 33.99 1.360
Sodium tungstate dehydrate Na2WO4.2H2O 0.14 0.0056
Methanol CH3OH 0.97 0.038
Triethyl amine (CH3CH2)3N 126.48 5.06
Ethyl chloroformate ClCO2C2H5 115.09 4.60
N-Ethy-2-aminomethyl pyrrolidine C7H16N2 97.92 3.91
Activated carbon C 2.79 0.111
Hyflow (Celite) O2Si 1.39 0.055
Acetone C3H6O 286.3 11.45
and/or
4. Duloxetine HCl
DTP Hydrochloride[(3-(dimethylamino)-1-(thiophen-2-yl) propan-1-one hydrochloride)]
C9H14ClNOS 293.44
6.81
Sodium borohydride NaBH4 65.73 1.52
Sodium hydroxide NaOH 116.37 2.70
Conc. Hydrochloric acid HCl 42.06 0.97
Sodium chloride NaCl 220.34 5.11
Methanol CH3OH 505.83 11.75
Dichloromethane CH2Cl2 285.86 6.64
Cyclohexane C6H12 1536.36 35.69
Water H2O 1112.61 25.85
1-Fluoronaphthalene C10H7F 152.85 3.55
Acetic acid CH3COOH 428.04 9.94
Sodamide NaNH2 53.07 1.23
Oxalic Acid dehydrate (COOH)2.2H2O 18.92 0.44
Dimethyl sulfoxide (CH3)2SO 93.69 2.17
Ethyl acetate C4H8O2 1368.9 31.80
Aq. Ammonia NH3 507.65 11.79
Dibenzoyl-L-tartaric acid C18H14O8 105.76 2.45
Di isopropyl amine 49.15 1.14
Phenyl chloroformate ClCOOC₆H₅ 74.44 1.73
Sodium bicarbonate NaHCO3 19.09 0.44
Ethyl acetate hydrochloride C4H8O2.HCl 72.77 1.70
Toluene C6H5CH3 257.16 5.97
PRE-FEASIBILITY REPORT M/s. BCJ PHARMA LLP
[7]
Activated carbon C 4.76 0.11
Celite O2Si 17.06 0.39
Acetone C3H6O 297.94 6.92
and/or
5. Bisoprolol
4 – Hydroxy Benzaldehyde C7H6O2 134.71 1.03
Sodium Borohydride NaBH4 115.20 0.88
Sodium Hydroxide NaOH 126.97 0.97
Water H2O 2531.71 19.50
Caustic flakes NaOH 44.45 0.34
Activated carbon C 12 0.092
Acetic acid CH3COOH 114.5 0.88
Toluene C7H8 650.76 5.012
2- Isopropoxy ethanol C5H12O2 212.44 1.636
Amberlyst resin - 97.00 0.747
Potassium Carbonate K2CO3 20.20 0.155
Epichlorohydrin (EPH) C3H5ClO 336.80 2.594
Mono Isopropyl amine (MIPA) C3H9N 363.73 2.80
IPA C3H6O 316.00 2.434
Fumaric acid C4H4O4 33.67 0.259
and/or
6. Lacidipine Hydrochloride
Bi phenyl compound -- 80.45 0.429
Succinic anhydride OCCH2CH2COO 22.72 0.121
Dichloro methane CH2Cl2 298.20 1.59
IPA C3H6O 149.10 0.795
Water H2O 220.50 1.176
Alluminium chloride AlCl3 17.85 0.095
Nitro compound -- 44.10 0.235
Methoxy derivative -- 29.19 0.155
Toluene C7H8 596.40 3.182
Methanol CH3OH 306.78 1.636
Activated carbon C 8.97 0.047
and/or
7. Losartan Potassium
Cyano biphenyl comp.( 4'-Methyl-2-cyanobiphenyl)
C14H11N 72.01
1.779
Dibromo adantine 53.35 1.318
Chloro benzene C6H5Cl 242.54 5.992
Immidazole C3H4N2 59.50 1.470
Sodium hydroxide NaOH 14.29 0.353
Toluene C7H8 673.65 16.64
Water H2O 910.43 22.49
Sodium borohydride NaBH4 12.37 0.305
Acetic acid CH3COOH 20.08 0.496
Methanol CH3OH 266.98 6.59
Sodium azide NaN3 21.20 0.523
Conc. Hydrochloric acid HCl 11.90 0.294
Potassium hydroxide KOH 16.40 0.405
Activated carbon C 7.36 0.181
and/or
8. Nisoldipine
3-Nitrobenzaldehyde C7H5NO3 102.14 1.277
Isopropyl alcohol C3H6O 808.33 10.109
Methyl aceto acetate C₅H₈O₃ 79.80 0.997
Piperidine C5H11N 6.38 0.0797
Acetic acid CH3COOH 4.78 0.0597
Methyl-3- aminocrotonate C₅H₉NO₂ 76.60 0.957
PRE-FEASIBILITY REPORT M/s. BCJ PHARMA LLP
[8]
Methanol CH3OH 616 7.703
Sodium hydroxide NaOH 47.60 0.595
Conc. Hydrochloric acid HCl 171.38 2.143
Carbon C 68.62 0.858
Water H2O 247.17 3.091
n-Benzyl-N-Methyl ethanolamine C10H15NO 54.26 0.678
Dichlorohexylcarbodiimide 17.41 0.217
Dimethylopropionic acid 3.19 0.039
Ethyl acetate C4H8O2 337.12 4.216
Acetone C3H6O 367.08 4.590
and/or
9. Olmesartan
4-(1-Hydroxy-1-methyl ethyl)-2-propyl-1H-imidazole-5 carboxylic acid ethyl ester
C12H20N2O3 105.0
0.622
5-(4’-Bromomethyl biphenyl-2-yl)-1-trityl-1H-tetrazole
C32H25N4Br 112.0
0.664
Potassium carbonate K2CO3 0.50 0.003
Sodium hydroxide Powder (NaOH Powder)
NaOH 9.0
0.0533
4-chloro methyl-5-methyl-2-oxo-3-dioxolene
C5H5O3Cl 93.0
0.551
Sodium Chloride(NaCl) NaCl 2.0 0.011
Toluene C7H8 200.0 1.185
Acetone C3H6O 300.0 1.778
and/or
10. Telmisartan
Bibenzimidazole C19H20N4 106.26 2.926
Bromo methyl ester C15H13BrO2 106.62 2.936
Sodium methoxide CH3ONa 18.45 0.508
Dimethyl formamide HCON(CH3)2 552.28 15.209
Acetone C3H6O 168.08 4.628
Water H2O 1131.43 31.159
Potassium Hydroxide KOH 43.34 1.193
Methanol CH3OH 477.04 13.137
Acetic acid CH3COOH 268.05 7.381
Activated Carbon C 7.45 0.205
Celite O2Si 5.01 0.138
and/or
11. Dutasteride
3-oxo-4-androstene -17 beta –carboxylic acid
4.0
0.333
2,5-bis (Trifluoromethyl) aniline (CF3)2C6H3NH2 4.0 0.333
Potassium Permanganate KMnO4 0.012 0.001
Sodium Carbonate Na2CO3 0.1 0.0083
Ethylene Glycol C2H6O2 0.1 0.0083
Acetic Acid C2H4O2 40.0 3.333
and/or
12. Tamsulosine
(S)-5-(2-aminopropyl)-2- methoxybenzene sulphonamide
C10H16N2O3S 8.68
0.668
2-(O-Ethoxy Phenoxy)ethyl Bromide C10H13BrO2 12.74 0.981
Methanol CH3OH 226.5 17.447
n-Haxane C6H14 52.22 4.022
50% NaOH NaOH 5.60 0.431
Ethyl acetate C4H8O2 200.0 15.406
Ethanol CH3CH2OH 182.42 14.051
Ethanolic HCl CH3CH2OH.HCl 17.36 1.337
DM Water H2O 371.68 28.630
PRE-FEASIBILITY REPORT M/s. BCJ PHARMA LLP
[9]
and/or
13. Fexofenadine Hydrochloride
2-[4-(4-Chlorobutanoyl)phenyl-2-methyl propionic acid
83.35
7.191
Methanolic Hydrochloric acid CH3OH.HCl 333.24 28.752
Sodium bicarbonate NaHCO3 0.40 0.034
Toluene C7H8 216.77 18.703
Water H2O 752.67 64.941
Azacyclonol C18H21NO 76.42 6.593
Potassium bicarbonate KHCO3 35.38 3.052
Potassium Iodide KI 0.74 0.063
Methyl-iso-butyl ketone(MIBK) C6H12O 410.53 35.421
De-natured Spirit (DNS) C2H5OH 98.69 8.515
Sodium borohydride NaBH4 7.32 0.631
Sodium Hydroxide NaOH 45.38 3.915
Hydrochloric acid HCl 52.22 4.505
Methanol CH3OH 515.96 44.517
Acetone C3H6O 219.60 18.947
Isopropyl alcohol C3H6O 332.59 28.696
Ethyl acetate C4H8O2 478.75 41.307
and/or
14. Loratidine
3-(3 Chlorophenylethyl )-2- Cyanopyridine
C₁₄H₁₁ClN₂ 142.24
3.892
4-Chloro-N- methylpiperidine C6H12ClN 78.28 2.142
Magnesium Mg 14.26 0.390
Hydrochloric acid HCl 21.39 0.585
Tetrahydrofuran C4H8O 706.72 19.340
Toluene C7H8 2641.07 72.273
Acetone C3H6O 494.70 13.537
Water H2O 1870.55 51.187
1,2-dibromomethane C2H4Br2 35.33 0.966
Poly phosphoric acid H3PO4 51.24 1.402
Caustic lye NaOH 75.37 2.062
Methylene dichloride CH2Cl2 464.12 12.700
Cyclo hexane C6H12 225.79 6.178
Ethylchloroformate ClCO2C2H5 54.36 1.487
Triethylamine (CH3CH2)3N 126.56 3.463
Activated carbon C 8.22 0.225
Acetonitrile CH3CN 507.36 13.884
and/or
15. Gabapentin
Isopropyl alcohol C3H8O 760.48 28.521
Ammonia NH3 109.38 4.102
CDAA 160.44 6.017
Hydrochloric acid HCl 441.65 16.563
Water H2O 1327.49 49.787
Sodium Hydroxide NaOH 239.90 8.997
Bromine Br2 140.78 5.280
MDC (Methylene dichloride) CH2Cl2 1771.88 66.453
Ethanol CH3CH2OH 751.94 28.201
Ethyl acetate C4H8O2 719.96 27.00
Tri ethylamine (CH3CH2)3N 48.76 1.828
Activated carbon C 3.19 0.119
Acetone C3H6O 1350.34 50.644
and/or
16. Pregabalin CMH ((+)-3-(carbamoylmethyl)-5- C9H17NO3 267.90 18.753
PRE-FEASIBILITY REPORT M/s. BCJ PHARMA LLP
[10]
methyl hexanoic acid)
R-(+)-1 Methyl benzyl amine C₈H₁₁N 143.60 10.052
methanol CH3OH 50.15 3.510
chloroform CHCl3 163.52 11.446
Sulfuric acid H2SO4 123.2 8.624
Water H2O 1181 82.674
Sodium hydroxide NaOH 24.00 1.680
Sodium hypochlorite NaOCl 127.34 8.914
Activated carbon C 4.62 0.323
Celite SiO2 0.83 0.058
Isopropyl alcohol C3H8O 393.00 27.511
and/or
17. Glimepiride
N-{4-[2-(3-ethyl-4-methyl-2-oxopyrroline)-1-caboxamido]ethyl} benzene sulphonamide
C16H21O4N3S
100.0
0.8
Trans-4-methylcyclohexyl isocyanate C8H13NO 52.0 0.416
Toluene C7H8 100.0 0.8
Acetone C3H6O 250.0 2.0
and/or
18. Larnoxicam
Pyridin-2-ylcarbamic chloride C6H5ClN2O 5.19 1.082
6-chloro-2-methyl-2H-thieno [2,3- e{1,2}thiazin-4-ol1,1- dioxide
C7H6ClNO3S2 8.40 1.751
Sodium methoxide CH3ONa 1.79 0.373
Methanol CH3OH 16.59 3.459
and/or
19. Lansoprazole
2-Chloromethyl-3-methyl-4-- 2,2,2 trifluoroethoxy Pyridine Hydrochloric acid
C9H8ONCl2F3 98.02 4.343
2-Mercapto BenzImidazole C7H6N2S 56.14 2.487
Sodium hydroxide NaOH 89.17 3.951
Methanol CH3OH 775.53 34.366
Water H2O 844.86 37.438
Sodium hypochlorite NaOCl 38.02 1.684
Sodium thiosulphate Na2S2O3 33.71 1.493
Ammonium acetate C2H7NO2 47.39 2.1
Diisopropyl ether C6H14O 430.68 19.084
Ethyl acetate C4H8O2 1751.08 77.595
Aq Ammonia NH4OH 8.24 0.365
Ethanol(denatured) CH3CH2OH 718.76 31.850
Acetone(denatured) C3H6O 1467.43 65.026
Potassium carbonate K2CO3 29.39 1.302
Activated carbon C 7.47 0.331
Celite SiO2 9.86 0.436
and/or
20. Omeprazole
2-Chloromethyl-- 3, 5 Dimethyl-- 4-methoxypyridine hydrochloride(Chloro compound)
C9H13Cl2NO 128.16 12.462
2-mercapto-5- methoxybenzimidazole (Mercapto compound)
C8H8N2OS 109.22 10.621
Sodium hydroxide NaOH 102.95 10.011
Methanol CH3OH 1805.1
175.536
Water H2O 1213.82
118.037
PRE-FEASIBILITY REPORT M/s. BCJ PHARMA LLP
[11]
Hydrogen peroxide H2O2 36.24 3.524
Ammoniummolybdate tetrahydrate (NH4)6Mo7O24.4H2O 0.60 0.0583
Sodium carbonate Na2CO3 1.44 0.140
Acetic acid C2H4O2 30.77 2.992
Triethyl amine (CH3CH2)3N 0.76 0.0739
Dichloro methane CH2Cl2 1304.01
126.808
Ammonium acetate C2H7NO2 25.48 2.477
Acetone C3H6O 50.97 4.956
and/or
21. Pantoprazole Sodium
HDMP (3,4- dimethoxypyridin-2-yl) methanol
C8H11NO3 70.38
8.316
Thionyl chloride Cl2OS 59.62 7.045
Methylene dichloride CH2Cl2 5161.78 609.95
Acetone C3H6O 165.90 19.604
Methanol CH3OH 664.31 78.50
DFMB (5-difluromethoxy -1H- benzimidazole-2-thiol)
80.99
9.570
Sodium chloride NaCl 42.62 5.036
Sodium Hydroxide NaOH 42.67 5.042
Cyclohexane C6H12 783.49 92.583
Water H2O 694.95 82.121
Sodium Hypochlorite NaClO 104.23 12.316
Sodium dihydrogen orthophosphate NaH2PO4 28.74 3.396
Sodium thiosulphate Na2S2O3 1.09 0.128
Ethyl acetate C4H8O2 1979.39 233.90
Diisopropyl ether (DIPE) C6H14O 2739.14 323.67
Ethanol CH3CH2OH 279.34 33.009
and/or
22. Rabeprazole Sodium
Chloro compound C11H17O2NCl2 136.87 6.065
2-Mercaptobenzimidazole C7H6N2S 79.39 3.518
Sodium hydroxide NaOH 170 7.533
Methanol CH3OH 518.8 22.989
Water H2O 838.32 37.148
Sodium hypochlorite NaClO 81.54 3.613
Sodium thiosulphate Na2S2O3 3.01 0.133
Acetic acid C2H4O2 75.28 3.335
Sodium chloride NaCl 75.28 3.335
Methylene dichloride CH2Cl2 1705.94 75.595
Ethyl acetate C4H8O2 988.60 43.807
Cyclohexane C6H12 931.88 41.294
Activated carbon C 3.61 0.1599
Celite SiO2 3.16 0.1400
Denatured Ethanol CH3CH2OH 427.51 18.944
DCM - 898.56 39.818
Di-isopropyl ether C6H14O 654.12 28.986
Toluene C7H8 624.03 27.652
and/or
23. Phenylephrine Hydrochloride
3-hydroxyAcetophenone HOC6H4COCH3 51.87 3.990
Ethyl acetate C4H8O2 129.22 9.941
Bromine Br2 31.12 2.394
Aluminium chloride AlCl3 1.03 0.079
Toluene C7H8 570.57 43.898
Sodium bicarbonate NaHCO3 51.87 3.990
PRE-FEASIBILITY REPORT M/s. BCJ PHARMA LLP
[12]
Sodium sulphate Na2SO4 5.18 0.398
Water H2O 1013.49 77.975
N-methyl benzyl amine C8H11N 38.90 2.992
IPA-HCl -- 311.22 23.944
Isopropyl alcohol C3H8O 466.83 35.916
Methanol CH3OH 245.69 18.902
10% palladium carbon - 7.78 0.598
Hydrogen gas H2 1.55 0.119
Activated carbon C 6.21 0.477
Liq Ammonia NH3 191.9 14.764
L(+)Tartaric acid C4H6O6 126.49 9.731
Acetone C3H6O 155.61 11.972
and/or
24. Prilocaine
Ortho Toluidine CH3C6H4NH2 10 0.185
2-Bromo Proponyl Bromide C3H4Br2O 10 0.185
O-Propyl Amine C3H9N 10 0.185
Toluene C7H8 200 3.703
Sodium Bi carbonate NaHCO3 0.7 0.012
Con. HCl HCl 2 0.037
Liq. Ammonia (25 %) NH3 50 0.9260
DCM -- 475 8.796
Acetone C3H6O 75 1.388
Isopropionic HCL -- 3 0.055
and/or
25. Sertraline Hydrochloride
4-(3,4 Dichlorophenyl) -,3,4- dihydro-1 2H – naphthalenone
C16H12Cl2O 69.35
1.123
Methylamine CH3NH2 7.38 0.119
Hexane C6H14 118.80 1.925
Toluene C7H8 118.80 1.925
Water H2O 712.8 11.550
Sodium borohydride NaBH4 8.33 0.134
Hydrochloric acid HCl 21.8 0.353
Methanol CH3OH 237.6 3.850
Activated carbon C 4.75 0.0770
Mandelic acid C6H5CH(OH)COOH 31.32 0.507
Sodium Hydroxide NaOH 15.84 0.256
Ethyl acetate C4H8O2 415.55 6.733
Sodium chloride NaCl 11.88 0.192
and/or
26. Simvastatin
Lovastatin C24H36O5 93.93 0.869
Potassium hydroxide (KOH) KOH 163.39 1.513
Catalyst SA -- 0.78 0.007
Conc. Hydrochloric acid HCl 394.38 3.652
BHT (Butylated hydroxy toluene) C15-H24-O 0.55 0.005
Immidazole C3H4N2 38.90 0.360
TBDMSi-Cl (tert- butyldimethylsilyl chloride)
C6H15ClSi 43.21
0.400
DMBC (2,2-Dimethyl Butylryl Chloride)
C6H11ClO 62.89
0.582
Tri ethyl amine (CH3CH2)3N 106.31 0.984
MSA (Methane Sulphonic Acid) -- 10.28 0.095
Sodium carbonate Na2CO3 11.49 0.106
Sodium chloride NaCl 33.86 0.313
Ammonia NH3 32.76 0.303
PRE-FEASIBILITY REPORT M/s. BCJ PHARMA LLP
[13]
Methanol CH3OH 1111.12 10.290
Toluene C7H8 1140.14 10.558
Ethyl acetate C4H8O2 1482.64 13.730
Water H2O 720.03 6.668
Ortho Phosphoric acid (OPA) H3PO4 24.79 0.229
Activated carbon C 12.87 0.119
Celite SiO2 2.82 0.026
MDC (Methylene dichloride) CH2Cl2 1195.74 11.073
Cyclohexane C6-H12 1227.75 11.370
Catalyst SB -- 0.30 0.0027
Catalyst SC -- 0.30 0.0027
3.6 MANUFATURING PROCESS AND FLOW DIAGRAM
For Manufacturing process and flow diagram with mass balance, please refer Annexure – 3 of EC application.
3.7 RESOURCE OPTIMIZATION / RECYCLING AND REUSE
* Unit intense to produce 100 MT/Month from any of product as per Annexure No. 3. The maximum water consumption and waste water generation will be arising from product Omeprazole.
** Chilled out water will be totally reroute again in chilling Plant.
*** Softener backwash & regeneration will be done on every fifteen days.
**** DM plant regeneration & Backwash will be done at (after 20000 L DM water generations).
HCl & H2SO4 & Ammonia Solutions generated from reaction column will be scrubbed into water scrubber
followed by alkali scrubber. Recovered HCl (20-30%), and H2SO4 (50-70%) & Ammonia Solutions will be
sold to local manufacturer. Copy of Agreement / MOU to sale HCL, H2SO4 & Ammonia Solutions will take
after getting EC.
3.8 AVAILABILITY OF WATER, ITS SOURCE, ENERGY / POWER REQUIREMENT AND SOURCE
Energy / Power Requirement & Its Source
Electric power requirement for existing project is 1000 KVA, which is procured from DGVCL.
Water Availability & Its Source
Source of Water: GIDC water Source
The water consumption & generation at the different usages, please refer Annexure 5 of EC
Application.
Disposal of Wastewater:
Domestic effluent is disposed in to Septic tank / Soak pit system. Industrial effluent after primary Treatment in to ETP and confirming to the CETP inlet norms shall be
disposed to CETP for its further treatment and final disposal.
3.9 QUANTITY OF WASTES TO BE GENERATED (LIQUID AND SOLID) AND SCHEME FOR THEIR
MANAGEMENT / DISPOSAL
PRE-FEASIBILITY REPORT M/s. BCJ PHARMA LLP
[14]
Hazardous waste generated from the industrial activity will be stored in a separate hazardous waste
storage area and it will be disposed at nearest TSDF site for further treatment and disposal.
The municipal solid wastes generated during operation phase will be disposed to bin of GIDC.
4. SITE ANALYSIS
4.1 CONNECTIVITY
The project site is well connected with all infrastructures like National Highway, Railway, Airport, telephone, internet, fax, post, etc.
Nearest city is Surat located 9.5 km in NNW direction from the project site.
State Highway No. 6 is located 0.94 Km in NE direction.
National Highway No.8 located 12.13 Km in E direction.
Nearest railway station is Sachin located 2.37 km in ESE direction from the project site.
Nearest airport is Surat located 12.48 km in WNW direction from the project site.
4.2 LAND FORM, LAND USE AND LAND OWNERSHIP
The proposed unit will be developed in a GIDC. The land is already Non-Agriculture. The Proposed project
activity will be developed as per plan lay out shown in Annexure – 2 of EC Application in GIDC. The proposed
project will not cause any permanent or temporary change to land use.
4.3 TOPOGRAPHY
The project area is plain and flat surface with elevation 42 m above MSL. However, in the NE part the elevation is in the range of 41 – 43 m above MSL, in the SW part the elevation is in the range of 42 – 43 m above MSL & in NW part the elevation is in the range of 42 – 43 m above MSL. In the buffer zone towards W the elevation rises to 43 m above MSL & towards NE, E & SE, and the elevation descend to 41 m above MSL.
4.4 EXISTING LAND USE PATTERN, SHORTEST DISTANCE FROM THE PERIPHERY OF THE PROJECT TO PERIPHERY OF THE FOREST, NATIONAL PARK, WILD LIFE SANCTUARY, ECO SENSITIVE AREA, WATER BODIES (DISTANCE FROM THE HFL OF THE RIVER), CRZ
The land is non agriculture. The project site is located in GIDC area. There shall be no forest, wild life sanctuary, eco sensitive area within 10 km from the project site. The details of water bodies and nearest park are mentioned below:
Tapi River is 11.47 km in NNW direction. Arabian Sea is 16.90 km in WSW direction. Vansda National Park is 83.5 km in ESE direction. Purna Wildlife Sanctuary is 90.40 km in E direction. Dandi Eco-Sensitive Zone is 22.5 Km in S
4.5 EXISTING INFRASTRUCTURE
PRE-FEASIBILITY REPORT M/s. BCJ PHARMA LLP
[15]
The proposed project is located in a GIDC. DGVCL is provide power supply. pucca road,
telephone & other communication network & drainage network in the area was developed.
Skilled & unskilled manpower are available within area. Ambulance and emergency fire &
medical service available round the clock.
5. PLANING BRIEF
5.1 PLANNING CONCEPT
The unit has proposed to manufacture Drugs. Proposed project activity will be carried out at
Plot No.: 7102, Road No. 71, Sachin-GIDC, Sachin, Tal.: Choryasi, Dist.: Surat, State: Gujarat. The Proposed project activity will be carried out in 1295 m2 unit area.
All the basic facilities like tap water, sanitation & drinking water, canteen & first aid box will
be provided within the premises.
The project site is well connected with the road, railway and airport. Finished product and
raw materials will be transported through road. There is no requirement for the development
of other road or railway.
5.2 POPULATION PROJECTION
During operation phase 32 people-Direct (30 men + 2 women), 32 employees
5.3 LAND USE PLANNING Please refer Annexure – 3 for land area.
5.4 ASSESSMENT OF INFRASTRUCTURE DEMAND (PHYSICAL & SOCIAL)
The proposed project is located in a GIDC. DGVCL is Provide power supply. Pucca road,
telephone & other communication network & drainage network in the area was developed.
Skilled & unskilled manpower are available within area. Ambulance and emergency fire &
medical service available round the clock.
Local people will be hired for new products and they will be trained within unit. Thus, no
social infrastructure will require.
5.5 AMENITIES / FACILITIES
All the basic facilities like tap water, sanitation & drinking water, will be provided within
premises.
First aid box, free medicines & doctor service (on call basis) will be provided.
Adequate PPE’s will be provided to all workers.
PRE-FEASIBILITY REPORT M/s. BCJ PHARMA LLP
[16]
6. PROPOSED INFRASTRUCTURE
The breakup of the land area is mentioned in the below table:
1. Industrial Area Total Area – 1295 m2
2. Residential Area Residential area is located 2.35 km in NNE direction.
Green Belt Proposed – 155 m2
4. Social Infrastructure Social infrastructure available within 10-15 km from project site.
5. Connectivity National Highway No. 8 is located 12.13 Km in E direction Nearest railway station – Sachin railway station is located 2.37 Km in ESE direction. Nearest Airport – Surat Airport 12.48 Km in WNW direction.
6. Drinking Water Management
Source of water for domestic & industrial purpose is from GIDC water.
7. Sewerage System Domestic effluent will be disposed in to existing Septic tank / Soak pit system. No Industrial effluent will be generated/ discharged.
8. Industrial Waste
Management
Discarded Containers/Bags – Collection, Storage, Decontamination and Disposal by selling to registered re-cyclers approved by GPCB/CPCB. Used Oil– Collection, Storage, Transportation, Disposal by selling to Registered Re-refiners approved by GPCB/CPCB.
9. Solid Waste Management MSW disposed to bin of nearby SMC.
10. Power Requirement &
Supply / Source
Source: Dakshin Gujarat Vij Company Ltd.
Proposed power requirement: 1000 KVA
7. REHABILITATION AND RESETTLEMENT (R & R) PLAN
The project is located within a GIDC therefore no Rehabilitation & Resettlement (R & R) plan is
involved in proposed project.
8. PROJECT SCHEDULE & COST ESTIMATES
PRE-FEASIBILITY REPORT M/s. BCJ PHARMA LLP
[17]
8.1 LIKELY DATE OF START OF CONSTRUCTION AND LIKELY DATE OF COMPLETION
Production of proposed product will be started after getting Environment Clearance (SEAC) and
CTE/CC&A from the GPCB.
8.2 PROJECT COST ESTIMATION Estimated cost for the proposed project is as under;
Details Description Approximate Recurring Cost Per Annum (Rs. in Lacs)
Approximate Capital Cost (Rs. in Lacs)
Land Adjacent GIDC plot will be required which was already purchased in past.
-- 110.00
Building , Raw Material & Finished Product Storage area
RCC G+1+1+1 floor and Roof type shed will be constructed. Existing roof type shed will be partly modified in RCC G+1+1+1 floor.
2.00 100.00
Plant & Machinery New machineries required for the proposed project.
-- 120.00
ETP & APCS New ETP will be provided. Bag filter will be provided in pulverizer section.
10.0 35.00
Green Belt Development
Proposed 155 m2 area will be developed as a green belt
0.50 3.00
CSR Activity Rain water harvesting will be developed nearby village Donate computer to nearby village school
-- 3.00
TOTAL
12.5 371.00
9. ANALYSIS OF PROPOSAL
9.1 FINANCIAL AND SOCIAL BENEFITS WITH SPECIAL EMPHASIS ON THE BENEFIT TO THE LOCAL PEOPLE INCLUDING TRIBAL POPULATION, IF ANY, IN THE AREA
Project is located in a GIDC. Therefore, No R & R plan involved in proposed project.
Due to proposed project, it is expected that employment will increase for people who reside nearby
project area. Approx. 30 men & 2 women will get employment directly.
Due to increase in raw material and product transportation activity, indirect employment will
generate.
As local people will get job, quality of living will be increase.
Due to green belt development, aesthetic value of local environment will improve.