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www.heartacademy.org CV Network – Vol. 14 No. 2 – April 2015 1

CV NetworkPromoting Cardiovascular Education, Research and Prevention

THE OFFICIAL BULLETIN OF THE INTERNATIONAL ACADEMY OF CARDIOVASCULAR SCIENCES

PUBLISHED WITH THE ASSISTANCE OF THE MYLES ROBINSON MEMORIAL HEART TRUST & ST. BONIFACE HOSPITAL FOUNDATION

Vol. 14 No. 2 • April 2015

In this issue02 Remembering Someone Special –

Attila Ziegelhoffer

03 IACS Strategic Planning Meeting Prague, Czech Republic • February 7-9, 2015

05 Awards presented in Prague February 7-9, 2015

06 Indo-Canadian Symposium Heart Failure: Progress & Prospects Thiruvananthapuram, India • March 11-15, 2015

09 Call for Nominations for 2015 Medal of Merit March 10-16, 2015

10 7th International Conference Recent Advances in Cardiovascular Sciences Noida, India • March 10-11, 2015

14 Third Forum to Promote Young Investigators and Centers of Excellence in Cardiovascular Research Omaha, USA • September 10-12, 2015

18 Call for Nominations of Fellows

19 International Symposium in Slovakia September 2-5, 2015

20 European Section Meeting of IACS Belgrade, Serbia • October 8-10, 2015

26 25th Scientific Forum Vittoria, Brazil • November 12-14, 2015

2 CV Network – Vol. 14 No. 2 – April 2015 www.heartacademy.org

In Memoriam

Attila Ziegelhöffer

With deep sorrow we have to announce that on 2/21 2015 our good friend and colleague

Ing. Attila Ziegelhöffer, DSc. passed away at the age of 80, after long-lasting disease. We lost a person who not only significantly contributed to the development of science and research in Slovakia, but also positively influenced all the people who came into contact with him. Over the years, his former students became established scientists, well-known at home and abroad, however, Attila continued with great enthusiasm in the education of young generation, until the last days of his life. And his students accepted him as a beloved tutor. He was always the bearer of good mood, positive thinking and inspiration. We have lost not only an outstanding scientist, but also a nice, open-minded and friendly man.

After graduating from the Faculty of Chemical Technology, Technical University in Bratislava, in 1959 he joined the Department of Experimental Surgery, SAS, currently, the Institute for Heart Research, SAS, where he became a co-founder of the Biochemical laboratory. Later, he contributed to the establishment of the good name of the Biochemical department and the IHR SAS at home and worldwide.

During the years of intensive research activities he reached a series of remarkable results, such as development of methods of heart preservation before transplantation; elaboration of some methods to protect artificially arrested heart against ischemia during cardiac surgery; administration of exogenous ATP was a novel approach at that time. He was also actively involved in studies of regulations and mechanisms of membrane transport and cell signaling in the myocardium; molecular mechanisms of adaptation processes in the normal and diabetic hearts, their participation in the endogenous myocardial protection, with particular regards to the role of mitochondria. Thus he can be regarded as a pioneer of both, Molecular Biochemistry and Cardiology in Slovakia. He shared his ideas and knowledge with many collaborators abroad, e.g., in Germany, Canada, Hungary, Denmark, Scotland and Czech republic, where he worked during his study stays or as a visiting professor.

Attila Ziegelhöffer had numerous functions in different scientific organization: e.g., he as a member of the Council of scientists SAS, SAS Assembly later. In the years 1993-2002 he was a Council member of the Slovak Society for Biochemistry and Molecular Biology, and later, served as its President, in addition to the elected Fellowship in the International Academy of Cardiovascular Sciences (FIACS). He also acted as a co-founder and member of the Joint Working Group of Experimental Cardiology in Slovakia and Czech republic.

He also served as a member of the Editorial Boards of several journals - General Physiology and Biophysics, Molecular and Cellular Biochemistry, Experimental and Clinical Cardiology, Basic Research in Cardiology, and many others.

Attila Ziegelhöffer actively participated in a number of scientific events at home and abroad, often in the position of the invited lecturer. He himself served as one of the main organizers of several international symposia at home and abroad dedicated to different aspects of experimental cardiology.

For his dedication to science, Attila Ziegelhöffer was repeatedly awarded with many distinctions at home including medals of Slovak Academy of Sciences and Slovak Medical Association, as well as by international awards, such as Distinguished Service Award in Cardiovascular Science, Medicine and Surgery given by International Academy of Cardiovascular Sciences.

Attila Ziegelhöffer was a very active person, with a special sense of humor, he loved traveling and meeting people, in his younger age, he enjoyed downhill skiing, fencing, and later on, working in his cottage.

Attila was a smart and nice person, excellent scientist and a good friend. We will miss him.

Tanya Ravingerova, Jan Slezak and colleagues

Attila Ziegelhöffer

Honour from ArgentinaDr. Naranjan Dhalla has been conferred an Honourary Doctorate Degree from the University of Buenos Aires in Buenos Aires. He also received a Gold Medal from the University of Buenos Aires in recognition of his research work. The University of Buenos Aires is one of the largest universities in the world with a student population of 240,000. While accepting these awards, Dr. Dhalla gave a talk on “Opportunities and Challenges in Preventing Ischemic Heart Disease”. During this visit, he also gave a talk to the Argentina Cardiology Society – Round Table Symposium on the “Benefits and Limitations of the Antioxidant Therapy in Cardiovascular Disease”.


Strategic Planning IACS Meeting

Prague • February 7– 9, 2015

ParticipantsNaranjan S Dhalla – Executive Director, IACS

Bohuslav Ostadal – President, IACSGrant N Pierce – President, North- American Section

Andras Varro – President, European SectionJan Slezak – Executive Council Member, IACS

Frank Kolar – Council Member, European SectionPetr Ostadal – Council Member, European Section

1. BackgroundInternational Academy of Cardiovascular Sciences (IACS) was founded in 1996 on the proposal of Prof. Naranjan Dhalla. Established by renowned cardiologists, both experimental and clinical, the Academy provides the organizational structure for the worldwide sharing of research and education in the field of heart health. The main goal of IACS is the continuous education of the cardiovascular community with the aim to contribute to the translation of basic knowledge into prevention, improved diagnosis and therapy of cardiovascular disease. Furthermore, Academy will continue in the recognition of achievements of cardiovascular investigators by Fellowship of the Academy as well as by major prizes to distinguished scientists and travel grants and awards for young investigators.

The aim of the Prague meeting was to discuss and recommend the future strategy of IACS. The members of this Strategic Committee appreciated very much the suggestions of several Executive Council Members they have received before the meeting.

2. Activities of individual sections of IACSIACS was originally composed of seven sections: North-American, South-American, European, Indian, Japanese, Russian and Chinese. Whereas the first five sections are very strong and their inner scientific activities are very stimulating, the remaining two sections are facing specific problems. Dr Dhalla promised to contact the leading persons and to discuss with them the possible solution.

Participants of the Prague meeting are convinced that the activities of individual sections should receive high degree of autonomy, both scientific and economic. This will facilitate their flexibility and effectiveness in the organization of the life of the Academy. The role of the Executive Council of IACS should be primarily the coordination of the activities of individual sections, including meetings, key-note speakers, young investigators as well as the fellowships and awards.

3. Sections meetings planned for 2015It was suggested that each section will organize one Annual Section Meeting open for all members of IACS; there will be no World Congresses of IACS.

North-American Section3rd Annual CV Forum for Promoting Centres of Excellence and Young Investigators, Omaha, Nebraska, USA, September 10-12, 2015;

South-American Section25th Scientific Forum, Vitoria, Brasil, November 12-14, 2015;

European Section:Annual Meeting in Belgrade, Serbia, October 7-11, 2015;International Symposium on Advances in Cardiovascular Research in Smolenice, Slovakia, September 2-5, 2015;

Indian SectionAnnual Meeting in Noida, India, March 10-11, 2015;Indo-Canadian Symposium, Trivandrum, India, March 12-14, 2015;

Japanese SectionAnnual Meeting should be organized during the 4th week of May, but it will depend upon obtaining funds from some partnership.

It was stressed, that the Sections have to start to prepare the meetings for 2016, the year of the 20th anniversary of the foundation of IACS. This fact should be mentioned during the all meetings.

4. WebsiteHigh-quality website is absolutely essential for the life of IACS. It was suggested to prepare the websites for each section with identical cover page, mutual links as well as the link to the website of IACS. The individual sections will be responsible for the content of their websites. Prof. Slezak offered to prepare the sample section cover page and to send the website to other sections for discussion.

5. DatabaseThe official database of individual sections is still missing. It should be suggested to all sections to build their own database for the distribution of different information, meetings, CVnetwork etc. The database should be constantly supplemented.

6. MembershipParticipants of the Prague meeting suggested introducing membership and membership fee for all sections. They are convinced that the small amount of money will not destroy the private budgets and on the other hand it will serve as a small but very needful contribution to cover the necessary expenses of individual sections. Membership fee will cover the official membership diploma, reduced registration fee, reduced fee for publication in the official journals of IACS and the possibility to suggest the new fellows of IACS. The annual fee may be different in individual sections and will amount to about 50 EUR; membership will be free for PhD students. Corporate membership might be useful for different companies, sponsors etc. Membership fees will be sent directly on the accounts of individual sections as the contribution to their budgets.


7. FellowshipAcademy will continue the recognition of achievements of cardiovascular investigators by the fellowship (FIACS). Fellowship is the result of the standard nomination and election process; the number of Fellows is limited to 250 maximum at any time. It was suggested to introduce the fellowship fee similarly as in the comparable scientific societies. The fee should be equal for all Fellows and should amount to about 100 EUR. Fellowship fees will be also sent on the accounts of individual sections. The Fellows who are not actively engaged in cardiovascular education and research may be considered for appointment as Fellows-Emeritus.

8. PublicationsThe actual information about the scientific activities of the Academy is an important presumption of the effective function. IACS publishes successfully the official bulletin CV Network; its Editorial Board was recently updated. Participants of the Prague meeting invite all sections to contribute regularly to CV Network in order to keep the Academy well informed. The arrangement of the individual issues should follow the activities of individual sections and the editorial work should be improved. CV Network will be distributed according to the databases of individual sections. The official journals of IACS are Canadian Journal of Physiology and Pharmacology, Current Research: Cardiology, Heart Failure Reviews and American Journal of Cardiovascular Drugs.

9. Fund raisingIn order to recognize young investigators and established scientists, the IACS has built a partnership with Pivotal Therapeutics Inc., Canadian Journal of Physiology and Pharmacology, Current Research: Cardiology and Morris Karmazyn for 3 to 5 years.

Accordingly, IACS has allocated USD 20,000 for the North-American Section, USD 10,000 for the European Section, USD 5,000 for the Indian Section and USD 5,000 for the South- American Section for young investigator competition, poster awards, young faculty orations and some named symposia sessions. These amounts include funds for awards to established investigators to be given at each Section. IACS is working with a Japanese device company to obtain funds for the Japanese Section Meeting as well as travel grants for students and fellows.

Participants of the Prague meeting would like to express the sincere thanks to all organizers of the section meetings for their invaluable effort in raising support for their meetings and symposia. It was repeatedly stressed that the possible support of the invited speakers should be limited to the accommodation and hospitality; transportation is excluded.

10. Honorary Life PresidencyPresident of IACS suggested introducing the Honorary Life Presidency in order to recognize the long-time efforts devoted to the success of IACS. He asked the Strategic Planning Committee Members for their support for two nominations on the occasion of the 20th anniversary of IACS:

(i) Professor Naranjan S. Dhalla, Executive Director and founder of IACS as the Honorary Life President of IACS;

(ii) Professor Makoto Nagano, founder of the Japanese Section as the Honorary Life President of the Japanese Section.

Participants of the Prague meeting unanimously agreed with this suggestion. It was decided to request the Executive Council Members for approval of these nominations.

Jennifer Hall (USA)

Chandrasekharim Kartha (India)

Ursula Muller-Werdan (Germany)

Danina Muntean (Romania)

Tanya Ravingerova (Slovakia)

Pram Tappia (Canada)

Belma Turan (Turkey)

Shelley Zieroth (Canada)

Larry Fliegel (Canada)

Sharon Mulvagh (USA)

Delfin Rodriguez (Cuba)

Petr Ostadal (Czech Republic)

Rajat Sethi (USA)

Madhu Khullar (India)

Elaine Maria Freitas (Brazil)

Paras Mishra (USA)

Paul Levine (USA)

Vladimir Jakovljevic (Serbia)

István Baczkó (Hungary)

Ram B. Singh (India)

Budhadeb Dawn (USA)

Naoki Makino (Japan)

Dinender Singla (USA)

Monika Bartekova (Slovakia)

Adriana Adameova (Slovakia)

EDITORIAL BOARD

Editorial Board 2015EDITORIAL ASSISTANTS

Teri Moffat (Canada) Eva Little (Canada)

CV NETwORk EDITOR

Ivan Berkowitz (Canada)


The gathering at a function before the distinguished Bures lecture given by Dr. Grant Pierce at the Czech Academy of Sciences in Prague – Drs. Grant Pierce (Canada), Jan Slezak (Slovak Republic), Bohuslav Ostadal (Czech Republic), Lucie Kubinova (Czech Republic), Naranjan Dhalla (Canada), Jaroslav Pokorny (Czech Republic), and Andras Varro (Hungary)

Awards Presented in Prague

Prague • February 7– 9, 2015

Dr. Naranjan Dhalla is presented in Prague with Laufberger Medal of Czech Physiological Society in recognition of Scientific Excellence and Contribution to the Enhancement of International Scientific Collaboration by Prof. Jaroslav Pokorny.

Dr. Grant Pierce is presented in Prague with Laufberger Medal of Czech Physiological Society in recognition of Scientific Excellence and Contribution to the Enhancement of International Scientific Collaboration by Prof. Jaroslav Pokorny.


Indo-Canadian Symposium on

Heart Failure: Progress & Prospects

March 11– 14, 2015

Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India

Symposium Report by Dr Surya Ramachandran, Rajiv Gandhi Centre for Biotechnology, India

Rajiv Gandhi Centre for Biotechnology, India in association with International Academy of Cardiovascular Sciences, Canada and

Kerala State Council for Science, Technology & Environment, India organized a symposium on Heart Failure in Thiruvananthapuram from March 11-14, 2015. The meeting hosted academicians and clinicians from Canada, USA, Slovakia, Turkey as well as India. The symposium addressed new strategic approaches to translate the recent advances in heart failure research for prevention and treatment of patients with cardiac failure.

Techniques in cardiovascular biology: Pre-conference workshopThe symposium began with a pre-conference workshop in association with the International Academy of Cardiovascular Sciences on March 11-12, 2015 on “Techniques in cardiovascular biology” targeting young researchers and clinicians keen on pursuing cardiovascular disease biology research. Techniques employed in cardiovascular research laboratories from animal cell culture to small animal surgical modalities, omics approaches and physiological measurements were demonstrated by experts in these domains. Introductory instructive lectures were followed by demonstration of experiments and interactive, stimulating discussions. Faculty for the preconference workshop included Dr Sanjay K Banerjee, Dr TR Santosh Kumar, Dr Madhulika Dixit, Dr Abdul Jaleel, Dr Ajith Kumar GS, Binil Raj SS, Vinitha A and Vikas Panchal.

Open forum for the public on prevention and treatment of heart diseasesAs a prequel to the symposium, the organizing committee arranged an outreach program for the general public on the evening of 12th March to educate the layman on heart diseases and conditions leading to heart failure. This forum was addressed by Dr Sivasankaran S, Dr Harikrishnan S and Dr Vivek, leading clinicians from the Sree Chitra Tirunal Institute of Medical Sciences and Technology, Thiruvananthapuram. The clinicians laid emphasis on prevention strategies to avoid heart problems in the future by adopting a healthy lifestyle today. Dr Sivasankaran gave importance to healthy life style with adequate exercise and balanced diet right from young age to prevent onset of chronic diseases later in life. Dr Harikrishnan answered questions from the public related to medical emergencies, therapeutic options, choices of diet and so on. Dr Vivek explained surgical and other treatment options after onset of heart failure.

Preconference Workshop: Techniques in Cardiovascular Biology, March 11-12, 2015

Outreach program for the general public


Two day Indo-Canadian Symposium on Heart Failure: Progress & ProspectsThe scientific sessions of the heart failure symposium started on an auspicious note with a formal inaugural ceremony on 13th morning. Professor Naranjan S Dhalla along with Professor M Radhakrishna Pillai, Director, Rajiv Gandhi Centre for Biotechnology, Professor C C Kartha, Organizing Chair, Professor Andras Varro, President European Section, IACS and Professor RK Goyal, Vice-President, Indian Section-IACS lighted the ceremonial lamp. Professor C C Kartha welcomed the august gathering. Professor M Radhakrishna Pillai, in his inaugural address highlighted the importance of translational medicine to bridge the gap between research and policy. Professor R K Goyal spoke on the activities of the Indian section of the IACS and Professor Andras Varro felicitated the gathering. Dr Surya Ramachandran proposed the vote of thanks.

Inauguration of first Indo Canadian Symposium on Heart failure: Progress & Prospects by (A) Professor M Radhakrishna Pillai and Guest of Honour Professor Naranjan S Dhalla followed by (B) address by Professor Dhalla (C) Welcome note by Professor C C Kartha (D) Inaugural address by Professor M Radhakrishna Pillai (E) Presidential address by Professor RK Goyal and (F) address by Professor Andras Varro

The Guest of Honor, Professor Naranjan S Dhalla was bestowed with a beautiful statue of Lord Padmanabha in all its splendor and glory by the Director, Professor M Radhakrishna Pillai. The International Academy of Cardiovascular Sciences also presented Professor C C Kartha with “Distinguished Leadership Award” and Dr Surya Ramachandran with “Distinguished Service Award”. The Indian Section of the IACS honored Professor Dinender K Singla and Professor Morris Karmazyn with the “Suresh K Gupta Oration Award for Excellence in Cardiovascular Sciences”.

Professor Dhalla initiated the technical sessions with an exemplary plenary session on “Cellular and molecular mechanisms for the development of heart failure” where he highlighted the role of α-adrenoreceptors and presented data showing that their blockade reverses heart failure-induced cardiac remodeling.

The first session was an overview on “Heart failure pathophysiology” with Dr Devendra K Agrawal (USA) suggesting high cholesterol and vitamin D deficiency to change the phenotype of epicardial adipose tissue and coronary arteries to pro-inflammatory in nature. The significance of epicardial adipose tissue was extended to the ischemic heart by Prof Jan Kyselovic (Bratislava). Dr Sankar Natesan (India) dwelt on InsP3R signaling and cardiac remodeling.

After a short coffee break, the speakers shared some novel insights in cardiac function with the audience. Dr Kenneth Rockwood (Canada) explained the complexity of fraility and its relationship with ageing and heart disease using his “clinico-mathematical models”. Dr Susan Howlett (Canada) shared her views on male-female differences in susceptibility to CVD and their repercussions on modifications in calcium handling at the cellular level. Dr Ghassan Bkaily (Quebec) described how nuclear membrane R-type calcium channels mediate cytosolic ET-1-induced increase of nuclear calcium in human vascular smooth muscle cells. He also presented Dr Danielle Jacques (Quebec) work on the role of endocardium endothelium in cardiac pathophysiology. An interesting facet of cardiac function was presented by Dr Peter P Nanasi who illustrated the factors influencing beat to beat variability of action potential duration and a young investigator, Ann Mary Johnson made a case for regeneration potential of c-kitpos cardiac stem cells and their longer quiescence.

(A) Statuette of Lord Padmanabha (B)Professor Pillai honoring Professor aranjan S Dhalla (C) “Suresh K Gupta award for excellence in cardiovascular sciences” awarded to Professor Morris Karmazyn (D) Professor Dinender K Singla receiving the “Suresh K Gupta award for excellence in cardiovascular sciences” award (E) Professor C C Kartha receiving the “Distinguished Leadership Award” and (D) Dr Surya Ramachandran receiving the “Distinguished Service Award”

An invigorating young investigator session post lunch led to a session on cardiomyopathy with lectures by Dr Uma Nahar Saikia (India) followed by Dr Madhu Khullar (India) who highlighted the role of myocardin related transcription factor-A in endothelial to mesenchymal transition. Dr Belma Turan (Turkey) gave compelling evidence of how controlling oxidative stress by beta blockers can be used to restore the failing heart in diabetic cardiomyopathy. A hectic yet stimulating day ended with another young investigator session leading to a gala dinner on the banks of the Arabian Sea.


The second day started with clinical sessions and a plenary lecture on heart failure management in India by Dr Ajit Mullassari (India) who advocated the need for heart failure registries in India and improving quality of life of chronic heart failure patients by effective clinical management. Dr Harikrishnan (India) extrapolated this theme with an example of the

Clockwise from left to right (A)Members of the audience (B) Dr Ren Ke LI in discussion with Dr Bkaily (C) Dr Agrawal with a student delegate and (D) the expert judging panel.

“Kerala Sadya” being served to the delegates on 14th afternoon

Trivandrum Heart Failure registry. He also figuratively explained how heart failure in the Indian subcontinent differs from western countries. Management of heart failure with preserved ejection fraction or diastolic heart failure was contemplated on by Dr Jacob Joseph (USA). He described a unique animal model of myocardial fibrosis and impaired diastolic function which would facilitate analysis of pathophysiology of this condition. Dr G Vijayaraghavan (India) was at his eloquent best on the role of B-type natriuretic peptide elevation and its prognostic value in patients with septic shock leading to cardiac failure. The efficacy of ultrasound targeted microbubble gene therapy in repairing the damaged heart was demonstrated by Dr Ren ke Li (Toronto).

One of the highlights of the symposium was the presentation of the Suresh K Gupta Oration awards instituted by the Indian Section of the Academy to Dr Dinender K Singla and Dr Morris Karmazyn. Dr Andras Varro and Dr C C Kartha chaired the session and also presented the cash awards and certificates. In his oration lecture, Dr Singla explained the process of 3D bio printing in heart diseases citing examples of using stem cells in cardiac repair while, Dr Morris Karmazyn gave proof of evidence supporting Ginseng as an effective adjuvant therapy for treatment of cardiac hypertrophy and heart failure including the reversal of the remodelling process. His work on myocardial remodeling demonstrated that ginseng (alcohol extract) could reverse hypertrophy and heart failure by inhibiting calcineurin activity, NFAT translocation and COX-2 upregulation.

The last session before lunch was initiated by Dr K Suresh (India) who put together clinically relevant biomarkers of heart failure followed by Dr Ajay Bahl (India) who dwelled on the issue of relapse in patients recovered from heart failure and their management. Antiarrythmic effects of amiodarone metabolites in different experimental models of arrhythmia were explained by Dr Andras Varro (Hungary). Dr Ravi Sundaresan (India) ended the session with a colourful depiction of how sirtuin signalling, calorie restriction and heart failure can be associated.

A sumptuous pure vegetarian lunch served in “pankthis” (meaning sitting in lines) in traditional Kerala style, called the “Kerala Sadya” (Sadya meaning banquet) placed on a banana plant leaf with 28 dishes, including three varieties of pickles and three varieties of desserts apart from the main course of rice and 21 other accompanying side dishes was literally a feast for the eyes.

After a rejuvenating luncheon, the last session of the symposium on pharmacotherapy in heart failure began with Dr Sanjay K Banerjee (India) sharing his experiences working on metabolites of ginger and their promising effect on cardiac hypertrophy. Dr Ramesh K Goyal (India) elaborated on the herbal formulations containing swertiamatin and swertisin as potential therapeutic compounds of diabetic cardiomyopathy. Dr H S Buttar (Canada) deliberated on the popularity of small animals like rats, mice, and rabbits for investigations related to chronic heart failure. Dr Veena Dhawan (India) emphasized on the importance of phytomedicines as an effective way of cardioprotection. The last speaker of the day was Dr Sandhya Sitasawad (India) who revealed the beneficial effects of calcium channel blockers such as Azelnidipine treatment on diabetes induced early left ventricular dysfunction.

The much awaited prizes for oral and poster presentations were given away during the valedictory function. The two “Naranjan S Dhalla Young Investigator Award for the Best Oral Presentation” were given to Mr Balaji Vekatesan for his talk on “CNP-surface functionalized chitosan nano particles effectively delivers the therapeutic agents to diseases rat heart” and Ms Prachi Umbarkar for her talk on “Monoamine oxidase A contributes to oxidative stress and is associated with development of diabetic cardiomyopathy”. The two “Naranjan S Dhalla Young Investigator Best Poster awards were given to Ms Kavitha Sashidharan and Ms Shammy Saphia.

The Naranjan S Dhalla Young Investigator awardees with Prof CC Kartha, Prof Andras Varro, Prof RK Goyal and Dr Surya Ramachandran


Group photograph of the speakers, guests, delegates and organizing committee members of Indo Canadian Symposium on Heart Failure: Progress and Prospects 2015

In spite of its tight schedule and back to back sessions, the symposium was a wonderful learning experience for the delegates particularly the student community. The sessions were attended with utmost fervour and enthusiasm by them. The meeting opened up several channels of discussion and collaborations among the participants. Our distinguished speakers thoroughly enjoyed the local hospitality provided by the organizing committee. The symposium ended on a positive note with promises of new alliances to extend further frontiers of research in heart failure and its allied ailments.

Nominations are invited for the 2015 Award of the Academy’s most prestigious Medal of Merit

Previous Winners

2001 Michael DeBakey (Houston, USA) and Richard Bing (Pasadena, USA)2002 Edwin Krebs (Seattle, USA) and Robert Furchgott (New York City, USA)2003 Eugene Braunwald (Boston, USA) and Robert Lefkowitz (Durham, USA)2004 Sir John Vane (London UK) and James Willerson (Houston USA)2005 Sir Magdi Yacoub (London UK) and Robert B. Jennings (Durham, USA)2006 Sir George Radda (Singapore) and Victor Dzau (Durham, USA)2007 Louis Ignarro (Los Angeles, USA), Sen. Wilbert Keon (Ottawa, Canada) and Jutta Schaper (Bad Nauheim, Germany)2008 Nirmal Ganguly (New Delhi, India), SIr Salvador Moncada (London, UK), Wolfgang Schaper (Bad Nauheim, Germany) and Howard Morgan (Lewisburg, USA)2009 Ernesto Carafoli (Padova, Italy) and Eric Olson (Dallas, USA)2010 Arnold M. Katz (Norwich, USA) and Laszlo Szerkes (Szeged, Hungary)2011 Jay Cohn (Minneapolis, USA) and Salim Yusuf (Hamilton, Canada)2012 Piero Anversa (Boston, USA), Laurentiu Popescu (Bucharest, Romania) and Makoto Nagano (Tokyo, Japan)2013 Roberto Bolli (Louisville, USA)2014 Ferid Murad (Washington, USA)

We also call for Nominations of individuals with outstanding achievements in cardiovascular research and education to be elected as Fellows of the Academy

Please submit short CV and contributions of the candidate by June 1, 2015 to Dr Naranjan S Dhalla, Executive Director. Email: [email protected]


7th International Conference on

Recent Advances in Cardiovascular Sciences

March 10– 11, 2015

Under the aegis of International Academy of Cardiovascular Sciences (IACS) held at Amity University, Noida, India

Amity Institute of Pharmacy, Amity University, Noida, India in association with International Academy of Cardiovascular

Sciences, Canada (India Section) organized an International Conference on “Recent Advances in Cardiovascular Sciences" on March 10-11, 2015. Distinguished Scientists from Canada, USA, UK, Louisville, England, Slovakia, Turkey, Saudi Arabia as well as India attended the conference and addressed new strategic approaches to translate the recent advances in combating cardiac diseases prevention and treatment.

The conference was inaugurated with an auspicious note and the ceremonial lamp was lighted by the dignitaries Prof. Naranjan S Dhalla, Prof. Morris Karmazyn, Prof. Dr. Harpal S Buttar, Prof. Dinender K Singla, Prof. Susan E Howlett, Prof. Kenneth Rockwood, Prof. Devendra K Agrawal, Prof. Suresh C Tyagi, Prof. Mahesh P Gupta, Prof. Jaipaul Singh, Prof. Belma Turan, Prof. Ramesh K Goyal, Prof. PC Dandiya, Prof. Ram Raghubir and Professor SS Agrawal, Organizing Secretary - (7-RACS) & Secretary General (IACS, India Section), Gp. Dy. Pro Vice Chancellor, Amity Universities. Prof. Balvinder Shukla, Vice Chancellor of Amity University, welcomed the delegates and distinguished guests and highlighted the importance of cardiovascular sciences to bridge the gap between research and its implementation policy.

Prof. Naranjan S Dhalla, Canada, in his keynote address enriched the gathering with his work on CO2-enriched water bath as a novel therapy for peripheral vascular diseases Peripheral artery disease (PAD) is a major health problem whereby narrowed arteries reduce blood flow to the ischemic limbs. Beneficial action of CO2 therapy on blood flow to hind limb might be due to the development of angiogenesis in the ischemic skeletal muscle. The inaugural session was concluded with vote of thanks by Prof. SK Gupta.

Oration and AwardsRamesh K Goyal award was given to Dr. Ghassan Bkaily, Professor, Universite de Sherbrooke, Canada “Role of sodium-hydrogen exchanger in hypertrophy and heart failure in hereditary cardiomyopathy” Dr. Bkaily concluded that NHE1 may play an important role in the development of heart failure and early death and inhibitors of this exchanger constitute promising drugs for treatment of hereditary cardiomyopathy. This work was supported by the Canadian Institute of Health Research.

Lighting the lamp Prof. A.K. Nagpal, Dr. W. Selvamurthy, Dr. Harpal S. Buttar, Prof. N.S. Dhalla, Prof (Dr.) Balvinder Shukla, Vice Chancellor, Amity University, Prof. S.S. Agrawal, Prof. R.C. Deka

Prof. Kenneth Rockwood, Dr. Susan Howlett & Dr. Rajiv Janardhana, during interactive session

Lighting the lamp Prof. A.K. Nagpal, Dr. W. Selvamurthy, Dr. Harpal S. Buttar, Prof. N.S. Dhalla,

Prof (Dr.) Balvinder Shukla, Vice Chancellor, Amity University, Prof. S.S. Agrawal, Prof. R.C. Deka

Prof. S.K. Gupta & Prof. S.S. Agrawal, presenting Ramesh Goyal Oration Award to Dr. Ghassan Bkaily

Prof. S.K. Gupta, Prof. S.S. Agrawal presenting Harpal Buttar Oration Award to Dr. Devendra Agrawal


Dr. N.S. Dhalla delivered keynote address


preventcardiac dysfunctionafter stem cell therapy. Dr Ram Raghubir from India highlighted the role of NADPH oxidase in cerebral ischemia-reperfusion injury.

Session three was on Innovative Molecular Cardiology and Diagnostics.

Prof. Susan E. Howlett, Canada, highlighted the male-female differences in cardiomyocyte calcium handling and contraction. She explored cellular mechanisms responsible for effects of estrogen on intracellular calcium handling at the level of the individual cardiomyocyte. We discovered that intracellular calcium levels are much lower in myocytes from female animals when compared to males. These sex differences arise through changes in the subcellular release of calcium from sarcoplasmic reticulum stores.

Harpal Buttar Oration Award given to Dr. Devendra Agrawal, Director, Creighton University School of Medicine, USA “Novel Mechanisms underlying plaque Instability in carotid stenosis” Professor Agrawal presenting the increased expression of TREM-1 in pSMCs of symptomatic than in asymptomatic patients suggest a potential role of TREM-1 in plaque destabilization. This is further supported by the pronounced effect of inflammatory cytokine, TNF-α, to increase of mRNA transcripts for TREM-1 and MMPs. Collectively, these findings suggest that selective blockade of TREM-1 may contribute to the development of new therapies and promising targets for stabilizing vulnerable atherosclerotic plaques.

Scientific SessionsThe first scientific session was on Clinical Management of heart Diseases and their complications, chaired by Prof. Kenneth Rockwood, Prof. Jaipaul Singh and Prof. Ajit Verma. Prof. Morris Karmazyn, London, stressed out the importance of “regulations of cardiac function in health and disease by adipakins”. Dr. W. Selvamurthy, President, Amity Science & Technology Innovation Foundation presented his excellent views on “lifestyle & cardiovascular health”.

The second scientific session on breaking scientific research in cardiology was chaired by Dr AG Ahangar, Dr SC Tiwari, Prof BC Das. Dr Kenneth Rockwood, Canada, gave presentation on frailty in older adults with heart disease. Dr Ren-Ke Li, Canada presented his work on Uterine angiogenic stem cells for regeneration of ischemic cardiomyopathy. He suggested that uterine angiogenic stem cells have the potential to induce neovascularizaionof ischemic tissue and




Makato Nagano Award for Distinguished Achievements in Cardiovascular Education presented to Prof. S.K. Gupta

Prof. Ren-Ke Lie, Dr. Morris Karmazyn, Dr. Ghassan Bkaily, Prof. (Dr.) Belma Turan

Prof. Morris Karmazyn & Prof. Jan Kyselovic, Chairing the session

Prof. Ren-Ke Lie, Dr. Morris Karmazyn, Dr. Ghassan Bkaily, Prof. (Dr.) Belma Turan,

Distinguished guests and speakers during the

Scientific Session

Distinguished guests and speakers during the Scientific Session

Distinguished guests and speakers during the Scientific Session

Distinguished invited speakers

Students and delegates during the conference


Prof. Jaipaul Singh, United Kingdom, presented his findings on fibrosis, hypertrophy, and remodeling, in pre, mild chronic and chronic diabetic myopathy. Prof. Addepalli Veeranjaneyulu, India, presented his study on treatment of cardiovascular autonomic neuropathin diabetis rats.

Lifestyle changes and dietary interventions help to mitigate and prevent cardiovascular diseasesProf. Harpal S Buttar, Department of Pathology and Laboratory Medicine, University of Ottawa, Ontario, Canada Prof. Buttar given the scope and prevalence of CVDs, a population health strategy- “Prevention is better than cure” would be the most appropriate model to adopt to deal with CVD-related mortality and morbidity. Such prophylactic measures would not only help in reducing obesity, diabetes some cancers and CVDs, but also the hospital and drug costs burdening the health care systems worldwide.

NPY receptors in the nucleus: What are they doing there? Prof. Danielle Jacques, Department of Anatomy and Cell Biology, University of Sherbrooke, Canada In summary Prof. Jacques express peptide receptors such as NPY receptors are present in the nuclear membranes of several types of cells, including endocardial endothelial cells. The presence of NPY and NPY receptors in the nucleus may contribute to the regulation of cell function, such as secretion, gene expression, hypertrophy and proliferation.

Genetically engineered embryonic stem cells enhances cradiac myocyte differentiation and attenuate adverse cardiac remodeling in the infarcted myocardium Prof. Dinender K Singla, College of Medicine, University of Central Florida. Prof. Singla work suggests that genetically modified ES cells enhance cardiac myocyte differentiation in vitro as well as in the infracted heart. Moreover, we also observed decrease in adverse cardiac remodeling that is associated with improved heart function.

Uterine angiogenic stem cells for regeneration of ischemic cardiomyopathy Prof. Ren-ke Li, Department of Cardiovascular Surgery, University Health Network and University of Toronto Using a bone marrow chimeric model, we identified multipotent stem cells in uterine tissue, which can differentiate into hematopoietic stem cells and angiogenic progenitor cells. After myocardial infarction, these stem cells mobilized to heart and prevented cardiac dysfunction. Uterine stem cells were also isolated and directly implanted into the heart after ischemic injury. The implanted cells survived in the area of implantation, functioned in blood vessel formation and improved heart function. These data suggest that uterine stem cells have the potential to induce neovascularization of ischemic tissue and prevent cardiac dysfunction after stem cell therapy.

Male-female differences in cardiomyocyte calcium handling and contraction Prof. Susan E Howlett, Dalhousie University, Halifax, Canada. Prof. Susan findings are important, because calcium is required to activate cardiac contraction, but too much or too little can promote to heart diseases. These effects of estrogen on calcium handling may contribute to the rise in cardiovascular diseases in older women.

Frailty in older adults with heart disease Prof. Kenneth Rockwood, Division of Geriatric Medicine, Dalhousie University, Halifax NS, Canada Frailty also challenges laboratory research: deficits accumulate in pre-clinical models too. Age-related changes in myocyte structure and function correlate better with the degree of frailty than with age, even in same strain models raised in the same environment.

Homocysteine elicits an M1 phenotype in murine macrophages through an EMMPRIN mediated pathway Prof. Suresh C Tyagi, Department of Physiology and Biophysics, School of Medicine, University of Louisville, KY Prof. Tyagi suggests that HHcy results in differentiation of macrophages towards the M1 phenotype. This effect seems to be mediated, at least in part by induction of EMMPRIN.

Cardioprotective effects of crategusoxycantha: Experimental and clinical Prof. Ramesh K Goyal, Executive Adviser (Research & Strategies) V ClinBio labs Sri Ramachandra University, Chennai In conclusion data suggest that C. oxycanthaextract possesses cardiotonic potential which may be attributed not only to the free radical scavenging and antioxidant activity by virtue of presence of rich amount of flavonoids and phenolic but also by inhibition of myocardial Na++ k+ ATPase enzyme possibly through the ursolic acid present in the extract. The clinical evidence correlates with the experimental observations. However, further systemic clinical studies are required to authenticate the cardioprotective potential.

Chronic heart failure: A disease of the brain Prof. R B Singh, Halberg Chronobiology Centre, University of Mineapolis, USA It is possible that increased circulating angiotensin II signaling can directly act on the central nervous system via the subfornical organ and the AP to increase sympathetic outflow.

Recent advances in medicine: India’s great contribution Prof. P C Dandiya, Emeritus Professor of Pharmacology, SMS Medical college, Jaipur The large number of psycho-pharmaceuticals, the benzodiazepines, the antipsychotic drugs, the antidepressant drugs like imipramine, selective NE reuptake inhibitors, selective serotonin inhibitors. These drugs changed the lives of the sick. How did this happen? Reserpine from R. Serpentina i.e. “sarpagangha” an ayurvedic drugs was found to deplete the brain of serotonin and non-epinephrine and this provided a tool to the world to understand brain functioning, the role of neurotransmitters in the body that allowed researchers to search for new block buster drugs that treated patients of depressions

Interactive session


and psychosis. These became the most selling drugs after the year 1990’s and changed the lives of millions of people around the world. The contribution of reserpine from India’s heritage has not been fully acknowledged but the fact remains that it changed the whole world of medicine. But for it the knowledge about brain would have remained vague and the treatments empirical.

Other distinguished speakers were Rajesh Kumar Suman, India, Mahesh P Gupta, USA, Prof. Ramesh K Goyal, India, Po, Arunabha Ray, JanKyselovic, Slovakia, Dinendra K Singla, USA, Rakesh Shukla, India.

Prof. SK Gupta was conferred with Makato Nagano Award for distinguished achievements in cardiovascular education presented by Prof. SS Agrawal, Prof. P.C. Dandiya & Prof. NS Dhalla. Life time achievement award was bestowed to Prof. SS Agrawal by Prof. Dhalla and Prof. SK Gupta.

George Jackowski Oral and Poster AwardsThe much awaited prizes for oral and poster presentations were given away during the valedictory function. Best Oral Presentation awards were given to Mr. Anupam Mittal, PGIMER, Chandigarh and Mr. Gurinder Bir Singh, PGIMER, Chandigarh.

Best Poster Presentation awards were given to Ms. Reshma P. L, CSIR-NIIST, Thiruvananthapuram and Mr. RK Sharma, Jamia Hamdard.

Closing CeremonyConcluding the ceremony, Dr. Ashok K. Chauhan, Honourable Founder President of Amity Universities & Chairman of AKC Group of Companies announced the formation of Amity International Foundation for Cardiovascular Sciences, which was well received by the audience.

Dr. N.S. Dhalla & Dr. Ashok K. Chauhan, Honourable Founder President, Amity University, who received the Life Time Achievement Award

Dr. N.S. Dhalla & Dr. Ashok K. Chauhan, Hon’ble Founder President, Amity University

Dr. N.S. Dhalla, Prof. S.K. Gupta presenting Life Time Achievement Award to Prof. S.S. Agrawal

Dr. N.S. Dhalla, Prof. S.K. Gupta presenting Distinguished Leadership Award to Prof. S.S. Agrawal

Dr. N.S. Dhalla & Dr. Ashok K. Chauhan, Hon’ble Founder President, Amity University

Dr. N.S. Dhalla, Prof. S.K. Gupta presenting Life Time Achievement Award to Prof. S.S. Agrawal

Prof. Morris Karmazyn & Dr. Tanveer Naved presenting the George Jackowski Oral Award to Mr. Gurinder Bir Singh, Research Scholar, PGIMER, Chandigarh

Prof. Morris Karmazyn & Dr. Tanveer Naved presenting the George Jackowski Oral Award to Mr. Gurinder Bir Singh, Research Scholar, PGIMER, Chandigarh

Student delegates at the poster presentation

Prof. Dinender K Singla presenting his research work

Student Delegates while Poster Presentation

Distinguish faculty and members of the organising committee during the closing ceremony

Prof. C. Tandon, Dr. Mahesh P. Gupta, Prof. Dinender K Singla, Prof. Addepalli Veeranjaneyulu & Prof. Sussan Howlet,

Annual Meeting of the International Academy of

Cardiovascular Sciences (IACS) North American Section

Omaha, Nebraska • September 10 – 12, 2015

The Harper Center at Creighton University302 N. 22nd St. Omaha, NE 68178

www.cvforum.orgRegister Today!

Third Forum to Promote Young Investigators and Centers of Excellence in Cardiovascular Research

• TwoYoungInvestigatorCompetitions(4presentersineachsession)

• TwoYoungFacultyOrationsCompetitions(4presentersineachsession)

• 2PosterCompetitions(4awardeeseach,8totalwinners)

• RegistrationandHotelAccommodationswillbeprovidedforalltraineesselectedfor oral presentations

• 10travelawardsintheamountof$500toawardedtostudentsonthebasisofmerit and need (not available to those selected for oral presentation)

Co-Chairs, Local Organizing Committee

Devendra K Agrawal PhD: [email protected] Irving H Zucker PhD: [email protected]

For additional questions, visit www.cvforum.org or contact Dane Marvin • T: (402) 280-3488 • E: [email protected]


International Academy of Cardiovascular Sciences Officers & Executive Council Members

Naranjan S Dhalla, Founder and Executive Director, Winnipeg, Canada

Bohuslav Ostadal, President, Prague, Czech Republic

Roberto Bolli, President-Elect, Louisville, USA

James T Willerson, Past President, Houston, USA

Eva Little, Administrative Assistant, Winnipeg, Canada

International Academy of Cardiovascular Sciences – North American Section Officers & Executive Council Members (2015– 2017) All IACS North American Section Council members are the members of the annual meeting Organizational Committee

Local Organizing Committee for Annual Meeting IACS North American Section

Devendra K Agrawal, Co-Chair and IACS Council Member, Omaha, USA

Irving H Zucker, Co-Chair, Omaha, USA Songcang Chen, Omaha, USA

Christopher Pelham, Omaha, USA Paras Kumar Mishra, Omaha, USA

Kaushik Patel, Omaha, USA Matthew Zimmerman, Omaha, USA

Jerrod E Lawrence, Administrator for Finance & Arrangements, Omaha, USA

Dane Marvin, Administrative Assistant, Omaha, USA

Annual Meeting of the International Academy of

Cardiovascular Sciences (IACS) North American Section

Grant Pierce, President, Winnipeg, Canada

Dennis McNamara, Past President, New Orleans, USA

Gary Lopaschuk, Vice President & Incoming President,

Edmonton, Canada

Dinender Singla, Secretary, Orlando, USA

Devendra K. Agrawal, Omaha, USA

Ghassan Bkaily, Sherbrooke, Canada

Michael Czubryt, Winnipeg, Canada

Susan Howlett, Halifax, Canada

Morris Karmazyn, London, Canada

Doug Lewandowski, Chicago, USA

Martin Morad, Charleston, USA

Ravichandran Ramasamy, New York, USA

Stephen Schaffer, Mobile, USA

Deepak Srivastava, San Francisco, USA

Balwant Tuana, Ottawa, Canada

Suresh Tyagi, Louisville, USA

Carin Wittnich, Toronto, Canada

Scientific Session Topics

• CerebrovascularDiseasesandStroke

• Inflammation,CytokinesandCardiovascular Disease

• CardiacandVascularRegeneration

• HighlightingSexDifferencesinCardiovascular Diseases

• ExerciseTraininginCardiovascularDisease

• DiabeticHeartFailure

• EpigeneticsandCardiovascularDisease

• NeuromodulationfortheTreatment of Cardiovascular Disease

• DiastolicHeartFailurewith Preserved Ejection Fraction (Mechanism and Therapy)

• NewConceptsinArrhythmogenesis

• NovelTherapiesTargeting Cardiac Metabolism

• Non-PharmacologicalTherapiesfor Heart Failure: Novel Devices

• Echocardiography:Latestmodalities for Imaging

• GeorgeJackowskiSymposium–Prevention of Heart Diseases

• DennisBMcNamaraSymposium–Pathophysiology and Treatment of Peripheral Vascular Disease

• SpecialSessiontohonorProfessor Edwin E Daniel and to celebrate his 90th Birthday


Invited Speakers & Session Chairs for North American Section Meeting of IACS – Omaha, Nebraska 2015

*Jeffrey L Ardell, PhD, Los Angeles, USA

*István Baczkó, PhD, Hungary

*Aruni Bhatnagar, PhD, Louisville, USA

*Ghassan Bkaily, PhD, Sherbrooke, Canada

*Roberto Bolli, PhD, Louisville, USA

*Harpal Buttar, DVM, PhD, Ottawa, Canada

*Enrique Castañeda Saldaña, Lima, Peru

*Michael Czubryt, PhD, Winnipeg, Canada

*Edwin E Daniel, PhD, Vancouver, Canada

*Michael G Del Core, MD, Omaha, USA

*Naranjan S Dhalla, PhD, MD Executive Director IACS, Canada

*Pedro D’Orléans-Juste, PhD, Sherbrooke, Canada

*Igor Efimov, PhD, Washington, DC, USA

*Galal El-Kilany, MD, Fujairah City, UAE

*Pierre B Fayad, MD, Omaha, USA

*Robert Felder, MD, Iowa City, USA

*Otoni M Gomes, MD, PhD, Brazil President IACS South America Section

Ramesh Goyal, PhD, Ahmedabad, India

*Justin Grobe, PhD, Iowa City, USA

*Susan Howlett, PhD, Halifax, Canada

*Krassimira Hristova, MD, PhD, Sofia, Bulgaria

*Morris Karmazyn, PhD, London, Canada

*CC Kartha, MD, Trivandrum, India

*Thomas Lohmeier, Minneapolis, USA

Gary Lopaschuk, PhD, Edmonton Canada

*Nilanjana Maulik, PhD, Farmington, USA

*Dennis McNamara, MD,

*Jawahar Lal Mehta, MD, PhD, Arkansas, USA

Martin Morad, PhD, Charleston, USA

*Michael J Moulton, MD, Omaha, USA

*Bohuslav Ostadal, MD, PhD, Prague, Czech Republic

*Kaushik Patel, PhD, Omaha, USA

*Grant Pierce, PhD President IACS North America Section

*Iraklis I Pipinos, MD, Omaha, USA

Fabio Recchia, MD, PhD, Philadelphia, USA

*Kathryn L Sandberg, PhD, Washington, DC, USA

*Stephen Schaffer, PhD, Mobile, USA

*Pawan K Singal, PhD, Winnipeg, Canada

*Dinender Singla, PhD, Orlando, USA

*Fabiola Sozzi, MD, PhD, Italy

Balwant Tuana, PhD, Ottawa, Canada

*Belma Turan, PhD, Ankara, Turkey

*Suresh K Tyagi, PhD, Louisville, USA

*András Varró, MD, PhD, Szeged, Hungary

*Han-Jun Wang, MD, PhD, Omaha, USA

*James T Willerson, MD, PhD, Houston, USA

*Carin Wittnich, PhD, Toronto, Canada

*Hong Zheng, MD, Omaha, USA

*Irving H Zucker, PhD, Omaha, USA

*ConfirmedPlease note that we are currently waiting to hear from other invited speakers and session chairs!

Call for AbstractsA key feature of this forum is its focus on young investigators. Two invited oral sessions for young faculty (within 10 years of first appointment) will be featured in sessions devoted to ba-sic cardiovascular science and clinical/translational medicine. There will also be award compe-titions for trainees in two categories: medical residents/postdoctoral fellows, and graduate stu-dents/medical students. Successful applicants will receive complimentary accommodation, reg-istration and hospitality; the top presentations in each oral competitive session, determined by committee at the Forum,willalsoreceiveaplaqueand$1,000check.Additionally,8awards will be given to best poster presentation and each of the 8 posterawardeeswillreceiveacertificateand$500.

Abstract Submission Process & Deadlines

The deadline for abstracts to be published and presented at the forum is June 1, 2015. The last date to withdraw a submitted abstract is August 26, 2015.

Abstracts are to be submitted as part of the online registration process. If your abstract is not fully prepared, you may still register. To do this, you will simply bypass the optional Abstract Submission page during your online registration. You may then return to edit your registration and submit the abstract at a later date.

Theabstractsubmissionfeeis$25.Ifyouaresubmittinganabstract,you must select this addi-tional fee during the online registration process (it will be added to your total).

Formatting requirements for abstracts are as follows: *Length limit is 250 words and must include the title, authors’ names and affiliations. Rich text formatting and special characters are permitted.

On separate lines, include: 1) the abstract title 2) author names [Last name, First name, middle initials] with numbers

to denote affiliation and presenting author’s name underlined 3) corresponding affiliations in numerical order 4) the abstract body [structured or free form styles are both permitted] 5) acknowledgements

Please do not include author titles or credentials in the abstract itself.

Notification of AcceptanceAuthors will be notified of acceptance or rejection of their abstracts via e-mail no later than July 15, 2015. The submitting author is responsible for notifying the other authors of the status of the abstract.

Oral PresentationsSpeakers are allocated approx. 20 minutes for the presentation and discussion.


Poster PresentationsTwo interactive poster sessions will be held during the meeting. Authors are requested to mount their posters from 5:00 – 7:00 PM on Thursday 10th September to remain until 4:00 PM on Saturday 12th September. Poster size should be 36” wide x 48” length. Poster figures should be easily readable from a distance and the authors should use clear, visible graphics and large text fonts. Material for mounting posters will be provided in the poster area. Authors are requested to be present by their posters from 4:00 – 7:00 PM on Friday 11th September for poster presen-tation and judging of the posters for awards.

Awards CompetitionsA key feature of this Forum is a focus on young faculty (within 10 years of first appointment) and young investigators (graduate students, medical students, postdoctoral fellows, clinical resi-dents and clinical fellows). Below are the list of four awards competitions for oral presentations and two award competitions for poster presentations that will highlight the contributions of the future leaders in the cardiovascular field.

Nominations of outstanding junior faculty members or trainees for consideration for these ses-sions are invited. A nomination package consists of the individual’s name, contact information, a brief 2-page CV highlighting their track record (e.g. NIH Biosketch), and an abstract (max. 250 words, as per the instructions in the Abstract Information section of the website, which will be available soon). Successful nominees, who are selected for oral presentation, will receive complimentary accommodation, registration and local hospitality (travel costs will be the re-sponsibility of each nominee). The top presentation in each competitive session, as determined by assigned judges at the Forum, will also receive a plaque and a monetary award. The deadline to receive nominations is June 1, 2015.

Additionally, there will be a total of eight poster awards, named in honor of Drs. Margaret P. Moffat and Morris Karmazyn. The winners of these awards will be selected from posters pre-sented at the Forum.

(1) The Grant Pierce Young Investigator Competition in Cardiovascular Sciences

This competition is open to graduate students and medical students working in the basic or clinical cardiovascular sciences. Four candidates will be invited to compete (registration fee will be reimbursed and hotel accommodation for a maximum of 3 days will be provided free of charge). The winner will receive a plaque and$1,000check.

(2) The James Willerson Young Investigator Competition in Cardiovascular Research

This competition is open to postdoctoral fellows, clinical residents and clinical fellows working in basic science or clinical medicine. Four candidates will be invited to compete (registration fee will be reimbursed and hotel accommodation for a maximum of 3 days will be provided free of charge). The winner will receive a plaque and$1,000check.

(3) The Eric Olson Young Faculty Orations in Cardiovascular Basic ScienceThis competition is open to faculty who are still in the first 10 years of their appointment. Four speakers will be invited to compete (registration fee will be reimbursed and hotel accommoda-tion for a maximum of 3 days will be provided free of charge). The winner willreceiveaplaqueand$1,000check.

(4) The Kern Wildenthal Young Faculty Orations in Clinical/Translational Cardiovascular MedicineThis competition is open to faculty who are still in the first 10 years of their appointment. Four speakers will be invited to compete (registration fee will be reimbursed and hotel accommoda-tion for

a maximum of 3 days will be provided free of charge). The winner willreceiveaplaqueand$1,000check.Additionally,therewillbeatotal of eight poster awards, as follows. The winners of these awards will be selected from posters presented at the Forum:

(5) Dr. Margaret P. Moffat Poster Award Competition (BiomedicalSciences)–4awardsof$500each

(6) Dr. Morris Karmazyn Poster Award Competition (TranslationalMedicine)–4awardsof$500each

Travel GrantsThere will be $5,000 distributed among 10 students ($500 perstudent) to support travel and other expenses. The students need to apply for the travel grant at the time of abstract submission (the option to apply is available during the online registration process). Awardees will be se-lected based upon the quality and content of the science, as judged by the reviewers.

Social ProgramThe social program will include the welcome reception and cocktails on the evening of Thurs-day 10th September at Harper Center, Creighton University and the awards banquet, dinner, cocktails and entertainment at Omaha’s Joslyn Art Museum on the evening of Saturday 12th September. Associated fees are included with paid registration and are complimentary for in-vited speakers.

Registration FeePaid conference registration includes access to all scientific sessions, meeting materials, coffee breaks, two lunches, dinner at the Welcome Reception at the Harper Center, and dinner at the Closing Awards Banquet at the Joslyn Art Museum. Please note that entrance to all events re-quires registration and a conference name badge.

Invited speakers will receive complimentary registration. The rates for all others are as follows:

Graduate Student / Medical Student / Postdoctoral Fellow / Clinical Resident / Clinical Fellow Registration:

Early Bird (by June 1, 2015) ...................................................$200Standard (after June 1, 2015) .................................................$250

General Attendee Registration:

Early Bird (by June 1, 2015) ...................................................$300Standard (after June 1,2015) ..................................................$350

Cancellation and RefundsWritten notification of cancellation must be provided via email to Dane Marvin ([email protected]). Cancellation by August 26,2015willresultinarefundofregis-trationfeespaidminusa$50fee for processing. Those cancelling on August 27, 2015 or later will not be refunded.

The IACS has pledged to provide

10 Travel Awards in the amount of $500 each

to be distributed based upon merit and need. To apply, simply upload an NIH-style biosketch when prompted during the registration process.


Omaha AirportThe airport of Omaha, Nebraska is called as Eppley Airfield with the symbol of “OMA”. Most of the airlines, including American (AA), United (UA), US Airways, Delta (DL), Frontier, Alaska and Southwest, flyintoEppleyAirfield.

Hotel AccommodationsHotel/Lodging fees are not included in the price of registration. Thus, all paid attendees must arrange lodging separately. For your convenience, we have blocked rooms at neighboring ho-tels for the duration of the conference: The Holiday Inn Downtown Omaha and The Fairfield Inn & Suites by Marriott Downtown Omaha.

The hotels are located about 3 miles or 5-minute drive from the airport and a three-minute drive or 10 minutes walking from the Harper Center at Creighton University. Both hotels offer free shuttle service from the airport to the hotel and also from the hotel to Harper Center. Rooms may be booked for the event immediately, even prior to registration. Invited speakers will stay in The Holiday Inn. The Holiday Inn has pledged to provide a dedicated complimentary shuttle service in its brand new Mercedes-Benz shuttle between the hotel and the Harper Center every fifteen minutes throughout the day. The shuttle will also transport guests to and from the Omaha Airport, which is a short drive fromthehotels.Roomratesatbothhotelsare$119/nightplus localtax. We have reserved the rooms for 3 nights, and guests may book between 1-3 nights. Stay for additional nights can be directly requested.

Hotel Option 1:

The Holiday Inn Downtown Omaha 1420 Cuming Street, Omaha, Nebraska 68102 Ph: (402) 341-0124 All King-size Beds / Free Wi-fi / Restaurant / 24hr Fitness Center / Pool

1. Go to the Holiday Inn Downtown Omaha website. http://www.ihg.com/holidayinn/hotels/us/en/omaha/omafc/hoteldetail

2. On the left hand side of the page, enter the number of guests occupying the room.

3. Enter the number of rooms you wish to reserve. 4. Add your check-in and check-out dates. 5. Click the “Have a Group Code” option and input the 3-letter code

“CSM” and select “Check Availability.” 6. The Guest Room types offered will populate along with the

negotiatednightlyrateof$119pluslocaltax.Followtheremaining prompts to reserve your overnight accommodations.

Hotel Option 2:

The Fairfield Inn & Suites Downtown Omaha 1501 Nicholas Street, Omaha, Nebraska 68102 Ph: (402) 280-1516 Free Breakfast / Free Wi-fi / Pool / Fitness Centerhttp://www.marriott.com/hotels/travel/omafd-fairfield-inn-and-suites-omaha-downtown

Meal InformationDinner will be catered at the welcome reception on Thursday, September 10th at the Harper Center Ballroom. Catered lunches will be provided at noon on Friday and Saturday, September 11th and 12th. Coffee and refreshments will be provided twice per day at the designated session break times. The awards banquet, held at the Joslyn Art Museum in downtown Omaha on Sat-urday, September 12th will feature fine catered dining. All of these meals are covered with paid registration.

Registrants will be responsible for providing their own breakfast each day as well as dinner on Friday, September 11th. The conference and hotels are in close proximity to Omaha’s historic “Old Market District,” which features dining options for nearly every conceivable taste and budget. The hotels affiliated with the meeting (The Holiday Inn Downtown Omaha and the Fairfield Inn and Suites Downtown Omaha) both offer a variety of breakfast options: Fairfield Inn offers free breakfast, and the Holiday Inn has an all-you-can-eat breakfast buffet in the res-taurant (invited speakers will receive a special rate of $5forthisbuffet).Bothhotelsofferfreeshuttleservice.

Please notify us of any food allergies or dietary restrictions when prompted during the online registration process.

Conference Registration/Check-inRegistration will be open on the first day of the conference (September 10th) beginning at 1:00 pm at the entrance of the Mike and Josie Harper Center at Creighton University. The registra-tion desk will close at 7:00 pm on Thursday. The desk will reopen on Friday and Saturday at 7:00 AM each day and will close at 6 PM on Friday (11th September) and 4:00 PM on Saturday (12th September).

Invitation for Full-Length Papers to Be Published in Canadian Journal of Physiology and Pharmacology

A certain number of presentations will be selected and invited for publication as full-length pa-pers in a special issue of the Canadian Journal of Physiology and Pharmacology, which is af-filiated with the Canadian Society of Pharmacology and Therapeutics, the Canadian Physiologi-cal Society, and the International Academy of Cardiovascular Sciences.

Call for Nominations as Fellows of individuals with outstanding achievements in cardiovascular research and education to be elected as Fellows of the Academy

Please submit short CV and contributions of the candidate by June 1, 2015 to Dr Naranjan S Dhalla, Executive Director. Email: [email protected]

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Organizers Institute for Heart Research Slovak Medical University Slovak Physiological Society Slovak Academy of Sciences Slovak Society of Cardiology Institute of Cardiovascular Sciences

Under the auspices of the

International Academy of Cardiovascular Sciences European Academy of Sciences and Arts

CONTACTS

Institute for Heart Research SAS Dúbravská cesta 9, P.O.B. 104, 840 05 Bratislava 45, Slovakia

Phone: 00421 2 54774405, Fax: 00421 2 54776637, E-mail: [email protected]; [email protected]

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International Program Committee

Andras Varro, Szeged, Hungary

Giuseppe Ambrosio, Perugia, Italy

Monika Bartekova, Bratislava, Slovakia

Istvan Baczko, Szeged, Hungary

Jerzy Beltowski, Lublin, Poland

Naranjan Dhalla, Winnipeg, Canada

Dragan Djuric, Belgrade, Serbia

Peter Ferdinandy, Budapest, Hungary

Ferenc Gallyas, Pecs, Hungary

Vladimir Jakovljevic, Kragujevac, Serbia

Barta Judit, Debrecen, Hungary

Ralph Kinscherf, Marburg, Germany

Keld Kjeldsen, Copenhagen, Denmark

Vladimir Kulchitsky, Minsk, Belarus

Frantisek Kolar, Prague, Czech Republic

Danina Muntean, Timisoara, Romania

Bohuslav Ostadal, Prague, Chech Republic

Petr Ostadal, Prague, Czech Republic

Zoltan Papp, Debrecen, Hungary

Olga Pechanova, Bratislava, Slovakia

Grant Pierce, Winnipeg, Canada

Tatiana Ravingerova, Bratislava, Slovakia

Rolf-Edgar Silber, Halle, Germany

Jaipaul Singh, Preston, UK

Tyagi Suresh, Louisville, USA

Jan Slezak, Bratislava, Slovakia

Belma Turan, Ankara, Turkey

Guy Vassort, Montpellier, France

Agnes Vegh, Szeged, Hungary

Lionetti Vincenzo, Pisa, Italy

Karl Werdan, Halle, Germany

Local CME Committee

Beljić Živković Teodora, Belgrade, Serbia

Deljanin Ilić Marina, Niš, Serbia

Djurić Dušan, Kragujevac, Serbia

Lazović Milica, Belgrade, Serbia

Novaković Budimka, Novi Sad, Serbia

Radonjić Vesela, Belgrade, Serbia

Stojkov Svetlana, Belgrade, Serbia

Tasić Nebojša, Belgrade, Serbia

Trifunović Zoran, Belgrade, Serbia

2nd European Section Meeting of the International Academy of Cardiovascular Sciences (IACS)

Scientific Topics

•AdvancesinAtherosclerosisandVascularBiology Research

•AdvancesinCoronaryArteryDiseaseandHeart Failure Research

•AdvancesinStrokeandPeripheralVascularDisease Research

•AdvancesinCardiacArrhythmiaResearchand Treatment

•AdvancesinCardiovascularSurgery:WhenBasic Meets Clinical Research

•AdvancesinCardiovascularRehabilitation:When Basic Meets Clinical Research

•AdvancesinCardiovascularDiagnosticsandBiomarkers Research

•EnvironmentalRiskFactors,Environment-Gene Interactions and Cardiovascular Health

•AdvancesinRiskManagement,Cardiovascular Prevention, Exercise and Nutrition

•AdvancesinTreatmentofHypertension,Diabetes Mellitus and Dyslipidemia

•DrugTherapy,CardiovascularToxicityandOther Side Effects; New Approaches to the Management of CVD

Confirmed Speakers and Titles for the 2nd European Section Meeting of IACS Belgrade 2015

International Speakers**Ambrosio Giuseppe, Division of Cardiology,

University of Perugia School of Medicine, Perugia, Italy

Myocardial hybernation: Pathophysiology and clinical implications

Baczko Istvan, Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Szeged, Szeged, Hungary

Effects of atrial selective ion channel modulators on chronic atrial tachypacing induced atrial fibrillation in dogs

Barta Judit, Institute of Cardiology and Heart Surgery, University of Debrecen Clinical Centre, Debrecen, Hungary

The right ventricular cardiomyocyte passive force is reduced in post-ischemic heart failure due to hypophosphorylation at Ser-282 of cardiac myosin binding protein C

Bartekova Monika, Institute for Heart Research, Slovak Academy of Sciences, Bratislava, Slovak Republic

Effect of prolonged intermittent restraint stress on molecular signalization in heart tissue

Beltowski Jerzy, Department of Pathophysiology, Medical University, Lublin, Poland

Hydrogen sulfide as a mediator of new lipolytic pathway in the adipose tissue

Gallyas Ferenc, Department of Biochemistry and Medical Chemistry, University of Pecs Medical School, Pecs, Hungary

Extranuclear effects of PARP activation: relevance in cardiovascular diseases

Ferdinandy Peter, Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary

Functional genomics of cardioprotection

Lionetti Vincenzo, Institute of Life Sciences, Scuola Superiore, Sant’Anna, Pisa, Italy

How to mend a broken heart: The epigenetic approach

Kinscherf Ralph, Department of Medical Cell Biology, Philipps-University Marburg, Marburg, Germany

Obstructive sleep apnea syndrome (OSAS): Alterations in skeletal muscle vascularization and angiogenic factors in mice and men

Kulchitsky Vladimir, Institute of Physiology, National Academy of Sciences, Minsk, Belarus

The ventrolateral medulla and heart rate variability under hypercapnia

Muntean Danina, Department of Pathophysiology, “Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania

Mitochondrial Effects of Lipid-Lowering Drugs

Ostadal Bohuslav, Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Chech Republic

Cardiac adaptation to overload

Ostadal Petr, Department of Cardiology, Cardiovascular Center, Na Homolce Hospital, Prague, Czech Republic

Extracorporeal life support in cardiogenic shock

Papp Zoltan, Institute of Cardiology, Division of Clinical Physiology, Research Center for Molecular Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary

Sarcomere active drugs in the therapy of acute heart failure


Pechanova Olga, Institute of Normal and Pathological Physiology, Slovak Academy of Sciences, Bratislava, Slovak Republic

Effects of nanopartıcle-loaded antıhypertensıve drugs on the cardıovascular system

Pierce N Grant, Department of Physiology and Pathophysiology, Faculty of Medicine, Institute of Cardiovascular Sciences, Canadian Centre for Agri-Food Research in Health and Medicine (CCARM), St. Boniface Hospital Research Centre, University of Manitoba, Winnipeg, Canada

The role of nuclear protein import in vascular cell proliferation: Target for novel therapies

Ravingerova Tanya, Department of Cardiovascular Physiology and Pathophysiology, Institute for Heart Research, Slovak Academy of Sciences, Bratislava, Slovak Republic

Novel “conditioning” approaches to repair the broken heart: From bench to a patient

Slezak Jan, Institute for Heart Research, Slovak Academy of Sciences, Bratislava, Slovak Republic

Radiation induced heart disease: Mechanisms and prevention

Turan Belma, Department of Biophysics, Ankara University Faculty of Medicine, Ankara, Turkey

Electrophysiological basis of metabolic syndrome induce cardiovascular disorders

Tyagi C Suresh, Department of Physiology and Biophysics, University of Louisville School of Medicine, Louisville, USA

Role H2S in cardiovascular remodeling

Varró Andras, Department of Pharmacology, Faculty of Medicine, University of Szeged, Szeged, Hungary

Antiarrhyhtmic effect of desethylamiodarone in experimental arrhythmia models

Vegh Agnes, Department of Pharmacology, Faculty of Medicine, University of Szeged, Szeged, Hungary

Protection with inorganic nitrites against ischaemia and reperfusion-induced ventricular arrhythmias

National Speakers**Borović Saša, Clinic for Cardiosurgery, Dedinje

Cardiovascular Institute, Belgrade, Serbia

Echocardiography measurement predicts severity of structural changes in the ascending aorta in patients with degenerative aortic stenosis

Dekleva Milica, Clinical Centre “Zvezdara”, Faculty of Medicine, University of Belgrade, Belgrade, Serbia

Assessment of myocardial mechanics during remodeling process after first myocardial infarction

Deljanin Ilić Marina, Institute for Treatment and Rehabilitation “Niška Banja”, Faculty of Medicine, University of Niš, Niš, Serbia

Music and cardiovascular health: Implications in cardiovascular rehabilitation

Djurić Dragan, Institute of Medical Physiology “Richard Burian”, Faculty of Medicine, University of Belgrade, Belgrade, Serbia

Homocysteine and thiolactone metabolites: Progress in cardiovascular research

Djurić Tamara, Laboratory for Radiobiology and Molecular Genetics, Vinča Institute of Nuclear Sciences, University of Belgrade, Belgrade, Serbia

Microarray in Serbia today: Implementation in cardiovascular diseases

Dimitrijević Srećković Vesna, Clinic for Endocrinology, Diabetes and Metabolism Disorders, Faculty of Medicine, University of Belgrade, Belgrade, Serbia

Abdominal obesity, risk of depression and early atherosclerosis in adolescents and youth-favourable effects of mediterranean diet

Ilić Stevan, Deartment of Cardiology, Clinic for Internal Medicine, Clinical Centre, Faculty of Medicine, University of Niš, Niš, Serbia

Cardiovascular rehabilitation – the saga continues

Jakovljević Vladimir, Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia

Oxidative stress in exercise: from animal models to applied investigations

Jonjev Živojin, Clinic for Cardiovascular Surgery, Institute for Cardiovascular Diseases of Vojvodina, Sremska Kamenica, Serbia

Coronary artery bypass grafting vs. percutaneous coronary intervention in single-vessel LAD disease

Jović Miomir, Department of Anesthesiology, Dedinje Cardiovascular Institute, Belgrade, Serbia

Hemodynamic monitoring – transpulmonary hemodilution – PCCO

Kostić Jelena, Institute for Cardiovascular Diseases, Clinical Centre of Serbia, Belgrade, Serbia

The effects of nicorandil on microvascular function in patients with ST segment elevation myocardial infarction undergoing primary PCI

Labudović Borović Milica, Kostić Jelena, Orlić Dejan, Institute of Histology and Embryology “Aleksandar Dj. Kostić”, Faculty of Medicine, University of Belgrade, Belgrade Serbia

Coronary thrombi aspirated from infarct-related artery in STEMI patients: An angiogenesis model

Miloradović Zoran, Ivanov Milan, Karanović Danijela, Vajić Una Jovana, Markovi Lipkovski Jasmina, Mihailović Stanojević Nevena, Grujić Milanović Jelica, Jovović Djurdjica, Laboratory for Cardiovascular Physiology, Institute of Medical Research, University of Belgrade, Belgrade, Serbia

Angiotensin 2 type 1 receptor blockade different affects postishemic kidney injuries in normotensive and hypertensive rats

Nikić Petar, Special Hospital for Prevention and Treatment of Cerebrovascular Diseases “St. Sava”, Belgrade, Serbia

Augmentationofcollateralcerebralflow–aneglected player in the treatment of acute ischemic stroke

Novaković Budimka, Centre for Dietetics and Nutrition, Department of Pharmacy, Faculty of Medicine University of Novi Sad, Novi Sad, Serbia

Management of nutritional risk for cardiovascular disease

Novokmet Slobodan, Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia

Cardiotoxic effects of some transition metal complexes on isolated perfused rat heart

Pekmezović Tatjana, Institute of Epidemiology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia

Challenges in stroke epidemiology and prevention

Petrović – Oggiano Gordana, Centre of Exellence in Nutrition and Metabolism, Institute for Medical Research, University of Belgrade, Belgrade, Serbia

Effect of physical activity on reduction of hyperlipidaemia in patients with cardiovascular risk

Popović Dejana, Institute for Cardiovascular Diseases, Clinical Centre of Serbia, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia

Cardiopulmonary exercise test in ischemic heart disease

Popović Tamara, Centre of Exellence in Nutrition and Metabolism, Institute for Medical Research, University of Belgrade, Belgrade, Serbia

Effects of fish oil supplementation on biochemical parameters, lipid profiles and oxidative stress in experimental model of aging and in DM2 patients with CVD

Prostran Milica, Institute of Pharmacology, Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Belgrade, Serbia

Novel approaches to the pathogenesis and the treatment of renal ischemia-reperfusion injury: From molecular aspects to clinical applicability

Radenković Miroslav, Institute of Pharmacology, Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Belgrade, Serbia

Endothelial dysfunction – pharmacological challenges

Ristić Medić Danijela, Centre of Exellence in Nutrition and Metabolism, Institute for Medical Research, University of Belgrade, Belgrade, Serbia

Are the saturated fatty acids a risk factors for cardiometabolic syndrome?

Stančić Ana, Korać Bato, Institute for Biological Research “Siniša Stanković”, University of Belgrade, Belgrade, Serbia

Mitochondria as key mediators of anesthetics preconditioning in human heart

Stevanović Predrag, Department of Anesthesiology, University Clinical Hospital Center “Dr Dragiša Mišović – Dedinje”, Belgrade, Serbia

Non-invasive hemodynamic monitoring in the perioperative period of high risk patients. When basic meets clinical practice

Stojanović Ivan, Clinic for Cardiosurgery, Dedinje Cardiovascular Institute, Belgrade, Serbia

Concomitant mitral repair surgery and coronary bypass grafting in patients with extremely impaired left ventricular function (EF < 15%)

Stojanovich Ljudmila, Clinic for Internal medicine, University Medical Center “Bežanijska Kosa”, Belgrade, Serbia

Antiphospholipid syndrome as the total cardiovascular risk evaluation and management



Call for Abstracts

The Program Committee is welcoming the submission of original contributions for oral and poster presentations for the meeting.

On-line Abstract Submission

On-line submission of abstracts is encouraged by the Program Committee. Scientific contributions should be according to the topics of the congress. Abstract must be written in English. Please, note that abstracts whose English language is of poor quality will be rejected.

PLEASE, PREFER THE TYPE OF PRESENTATION (oral or poster). Accepted abstracts will be scheduled for the type of presentations by the authority of the Program Committee.

IMPORTANT NOTICE – THE DEADLINE FOR ABSTRACT SUBMISSION IS JUNE 25, 2015.

ABSTRACTS TO BE SEND ONLY TO THE E-MAIL ADDRESSES OF THE PROGRAM/ORGANIZING COMMITTEE [email protected] or [email protected]

THE NUMBER OF ABSTRACTS IS NOT LIMITED.

Only abstracts accompanied by the payment of the registration fee will be considered for inclusion in Final Program and publication in Abstract Book. The transmission of the abstracts via fax, sending floppydiscs,CDorUSBbystandardmail isnotacceptable.Lateabstracts will NOT be accepted.

Instructions for Authors

1) Abstracts should contain short TITTLE; a list of AUTHOR(S); the INSTITUTION(S) (Italic) where the investigation was performed and the TEXT.

2) The title should be written in capital and bold letters. Underline the presenting author.

3)Abstracts should state the study’s objective, briefly describethe MATERIALS AND METHOD used, summarize the RESULTS obtained and state the CONCLUSIONS.

4) The recommended font is Time New Roman and font size 12. Kindly set the language to English.

5) Type the entire abstract single-spaced without margins at the top of sides.

6) Abstracts should contain no more than 250 words. Abstracts received after the deadline and abstracts not complied according to the instructions will not be accepted.

EXAMPLE:

THE EFFECTS OF NITRIC OXIDE SYNTHASE- OR LIPOXYGENASE INHIBITION ON CORONARY FLOW AND NITRITE OUTFLOW IN ISOLATED RAT HEART

Srejović I1, Jakovljević J2

1Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac; 2Institute of Medical Physiology “Richard Burian”, Faculty of Medicine, University of Belgrade, Belgrade, Serbia

The aim of this study was to assess the changes of coronary flow and nitrite outflow under inhibition of nitric oxide synthaseby L-NAME or lipoxygenase induced by 9 nordihydroguaiaretic (NDGA, LOX-inhibition) acid in isolated rat heart. The hearts of male Wistar albino rats (n=18, age 8 weeks, body mass 180-200 g) were retrograde perfused according to the Langendorff technique at gradually increased constant perfusion pressure conditions (CPP,40-120cmH2O)whichinducedflow-dependentNOrelease(nitriteoutflow)...

Notification of Acceptance

Authors will be informed of their abstract acceptance (or rejection) not later then July 15, 2015. For this notification, the correct mailing address including phone, fax number and e-mail address is essential. The registered author is responsible for informing all authors of the status of the abstract.

Date of Announcement/Abstract Deadline

The first announcement: first half of February 2015Second announcement: end of April 2015Abstracts deadline: June 25, 2015Notification of abstracts acceptance: July 15, 2015The final program: first half of September 2015

Meeting Date

October 8-10, 2015

Stoičkov Viktor, Institute for Treatment and Rehabilitation “Niška Banja“, Faculty of Medicine, University of Niš, Niš, Serbia

Exercise training in patients with heart failure: Which beneficial effects?

Tasić Nebojša, Clinic for Cardiology, Dedinje Cardiovascular Institute, Belgrade, Serbia

Novel factors in development of atherosclerosis plaques: Clinicians view

Todorović Z, Djukanović N, Protić D, Mugoša S, Obradović S, Ostojić M, Institute of Pharmacology, Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Belgrade, Serbia

Resistance to antiplatelet agents

Trifunović Danijela, Institute for Cardiovascular Diseases, Clinical Centre of Serbia, University of Belgrade, Belgrade, Serbia

Metabolic,inflammatoryandhaemodynamicpredictors of coronary microcirculation recovery in the infarct region after pPCI

Trifunović Zoran, Clinic for Cardiosurgery, Military Medical Academy, Belgrade, Serbia

Intramyocardial bone marrow mononuclear cells implantation concomitant to CABG surgery in ischemic cardiomyopathy

Velimirović Milica, Petronijević Nataša, Institute of Biochemistry, Faculty of Medicine, University of Belgrade, Belgrade, Serbia

Changes of NADPH oxidase and matrix metalloproteinase 9 expression are prevented by pretreatment of vitamin D3 and dehydroascorbic acid in animal model of stroke

Vranic Ivana, Institute for Cardiovascular Diseases, Clinical Centre of Serbia, University of Belgrade, Belgrade, Serbia

S wave in V1-V3, detectable sign of asymptomatic aortic stenosis on ECG

Zdravković Marija, Clinic for Internal Medicine, University Medical Center “Bežanijska Kosa”, Belgrade, Serbia

Hypertension and Physical Activity - Prognostic and Therapeutic Issues

Živković Maja, Laboratory for Radiobiology and Molecular Genetics, Vinča Institute of Nuclear Sciences, University of Belgrade, Belgrade, Serbia

The 9p21 chromosomal locus in atherosclerosis

Živković Vladimir, Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia

Cardiac anaphylaxis in isolated mice heart: Focus on L-arginine/NO system

** Surnames are given following alphabetical order.



Meeting Venue

Hotel Crowne Plaza, Belgrade, Republic of Serbia(participation upon registration only)

Registration

The meeting desk will be open on:October 08th 08.00 – 19.00October 09th 08.00 – 19.00October 10th 08.00 – 13.00

Registration Fee

(before September 1, 2015 or after September 1, 2015)

PARTICIPANTS (except invited speakers) ....................... 50 € or 70 €STUDENTS (only undergraduate) ............................... *free of charge*Certificate required

Notice

For attendees from abroad – payment in Euro to account of the Serbian Physiological Society:

INTERMEDIARY BANK/CORRESPONDENT BANKSWIFT – BIC: DRESDEFFName: DRESDNER BANK AGCity, Country: FRANKFURT AM MAIN, GERMANY

ACCOUNT WITH INSTITUTION/BENEFICIARY’S BANKSWIFT – BIC: KOBBRSBGXXXName: KOMERCIJALNA BANKA A.D. BEOGRADStreet: SVETOG SAVE 14City, Country: BEOGRAD, REPUBLIC OF SERBIA

BENEFICIARYIBAN/Account Number: RS35205007040000174821Name: DRUŠTVO FIZIOLOGA REP. SRBIJEStreet: DR SUBOTICA BR 8City, Country: 11000 BEOGRAD, REPUBLIC OF SERBIA

For attendees from Serbia ONLY – payment in Dinars (according to the official currency rate on the day of payment) to Komercijalna Banka A. D. account of the Serbian Physiological Society number: 205-40932-94 KOMERCIJALNA BANKA A.D.

Full registration fee includes admission to all scientific sessions, opening ceremony, welcome reception, cocktail, and receiving abstract book with final program. The meeting will be CME accredited.

CME Accredited Program for Clinicians & Pharmacists

Three Day-Course for Health Practitioners with Final Single Choice Quiz Entitled “Heart Disease: How New Research May Lead to New Treatments”

Each of the following courses is granted with 10 credits for participants:

• 08.10.2015.NEWDRUGS&TECHNOLOGIESo Accreditation No: A-1-800/15 (participants are physicians only),o Continuing education program accredited by the Health

Council of Serbia No. 153-02-416/2015-01, date 03.03.2015;o Lectures & Test preparation: Nebojša Tasić, Dušan Djurić

• 09.10.2015.CLINICALPRACTICEGUIDELINESo Accreditation No: A-1-594/15 (participants are physicians only),o Continuing education program accredited by the Health Council

of Serbia

No. 153-02-416/2015-01, date 03.03.2015;o Lectures & Test preparation: Teodora Belić Živković, Dušan Djurić

• 10.10.2015.LIFESTYLEMANAGEMENTINCARDIOVASCULARDISEASESo Accreditation No: B-27/15 (participants are pharmacists and

physicians),o Continuing education program accredited by the Health

Council of Serbia No. 153-02-416/2015-01, date 03.03.2015;o Lectures & Test preparation: Vesela Radonjić, Milica Lazović, Budimka Novaković, Svetlana Stojkov, Dušan Djurić

Lunch, Coffee or Refreshment

Lunch, coffee or refreshment should be provided by sponsors of the meeting or on a commercial basis in a restaurant of the meeting venue during the working days of the meeting. Gala dinner is not included in the registration fee and should be provided with additional cost of 25 Euro per person.

Official Language

Official language of the meeting will be English, however for the accredited CME three daycourses for health practitioners Serbian language will be used ONLY. No simultaneous translation will be provided. All abstracts will be published in English.

Oral Presentation

Speakers (except key note speakers) are allocated 20 or 15 minutes for the presentation with a discussion time according to the final program.

Poster Presentation

Two interactive poster sessions will be held during the meeting. Authors are requested to mount their posters from 9.00 to 19.00 on the day of the poster presentation. Poster size should be 120 (height) cm x 80 (width) cm. Poster figures should be designed to be viewed from a distance and the authors should use clear, visible graphics and large text fonts. Material for mounting posters will be provided in the poster area. Authors are requested to be present by their posters during the poster session for which their poster has been scheduled.

Awards Notice

The International Academy of Cardiovascular Sciences in association with the European Section will provide funds for accommodation and hospitality for 8 (eight) speakers in two scientific sessions, namely Sir Magdi Yacoub Symposia and George Jackowski Young Investigator Award competition. Furthermore two individuals selected from the invited speakers list will be awarded by the Professor Bohuslav Ostadal (Prague, Czech Republic) and Professor Jan Slezak (Bratislava, Slovak Republic) Awards for the Excellence in Cardiovascular Research. Finally, 4 speakers for the Young Investigator Competition shall be selected by the Council Members of the IACS-Europe Section. In addition IACS will provide 8 (eight) poster awards in the honour of Professor Guy Vassort (Montpelier, France) and Professor Elizabeth Roth (Pecs, Hungary). Poster Awards will be selected by a panel of judges appointed by the Local Program/Organizing Committee.

Audiovisual Facilities

For key note lectures and for other oral presentations, video beam projection will be available in a conference room. Presentations should be prepared in “Power Point”(*.ppt file). For special audiovisual facilities, please send in advance a special request to the Program/Organizing Committee.


Social Program

The social program will include convivial (welcome reception, cocktail) and cultural (city tours, visits to museums etc.) events; only the first will be covered by the registration fee. Please contact meeting desk for special inquiries.

Accomodation

Hotel accommodation and arrival/departure service will be organized in a different price categories and at special rates. Please contact [email protected]

In order to receive an e-mail invitation and/or confirmation, please indicate your e-mail address.

Cancellation or Refunds

Notification of cancellation should be sent in writing to the Program/Organizing Committee. If a cancellation is received before September 1, 2015, 70% of the total amount will be refunded to the participant. We regret that no refunds can be given for cancellations received on or after that date. Please note that for administrative reasons, refunds will be dealt with after the meeting.

Invitation for Full-Length Papers to be Published in Canadian Journal of

Physiology and Pharmacology

Certain number of presentations will be selected and invited to be published as a full-length papers in a special issue of the Canadian Journal of Physiology and Pharmacology, which is affiliated with the Canadian Society of Pharmacology and Therapeutics, the Canadian Physiological Society, and the International Academy of Cardiovascular Sciences.

For this option it will be possible upon invitation and following peer-review procedure.

Program Outline

Hotel Crowne Plaza, Belgrade, Serbia

Wednesday, October 7, 2015Arrival

Thursday, October 8, 201509:00–13:00 Opening Ceremony/Scientific Sessions

(two parallel sessions)13:00–15:00 Lunch Break15:00–17:00 Scientific Sessions (two parallel sessions)17:00–19:00 Poster Session I with Wine and Cheese

(in parallel CME sessions in Serbian)

Friday, October 9, 201509:00–13:00 Scientific Sessions (two parallel sessions)13:00–15:00 Lunch Break15:00–17:00 Scientific Sessions (two parallel sessions)17:00–19:00 Poster Session II with Wine and Cheese

(in parallel CME sessions in Serbian)20:00 Dinner with Music in Skadarlija Bohemian Quarter

Saturday, October 10, 201509:00-13:00 Scientific Sessions (two parallel sessions)15:00-19:00 CME Sessions in Serbian13:00-19:00 Excursion to Serbia Countryside with Lunch and Wine Tasting20:00 Gala Dinner/ IACS Awards Session (Hotel Park)

Sunday, October 11, 2015Departure

ENDORSED BY

Hypertension, Infarction, Stroke and Prevention AssociationSerbian Physiological Society

Faculty of Medicine University of BelgradeFaculty of Medical Sciences University of Kragujevac

International Atherosclerosis Society

Special Thanks for SupportThe International Academy of Sciences is grateful to the following institutions and individuals for their partnership to support our symposia and awards program:

1. Pivotal Therapeutics Inc., Woodbridge, Ontario

2. Mitsubishi Rayon Inc., Tokyo, Japan

3. Canadian Journal of Physiology and Pharmacology, NRC Press, Ottawa, Ontario

4. Current Research: Cardiology, Pulsus, Toronto, Ontario

5. Dr. Morris Karmazyn, London, Ontario

The Academy is indebted to the Myles Robinson Memorial Heart Trust and St. Boniface Hospital Foundation for their contribution in publishing CV Network and website development.

Our gratitude is also extended to The Asper Foundation, The Sir Thomas Cropo Foundation and Flax Council Canada for sponsoring our 6th Harold Buchwald Heart Health Luncheon, and to the Levit Family for support of Yetta and Jack Levit Distinguished Lectures in Winnipeg.

Naranjan S. DhallaExecutive Director, IACS

Printed in Canada – ISSN 1683-0784 Publications Agreement # 40804514

promoting cardiovascular education, research and prevention … · promoting cardiovascular...

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