ProteinsChapter 5

Big Idea #2: Structure Meets Function

Basic Unit of Proteins

Amino Acid:

Review:

What are the constant domains of an amino acid?

What is the variable region?

Types of Amino Acids What

functional groups can you recognize in the variable regions?

How might these impact how the variable region functions?

How does the amino acid chain dictate protein

structure?

Modeling Activity

Let’s use pipecleaners to model protein structure.

What limitations do we have?

What impacts each level of structure?

Key Protein Functions

Can you give an example of each? (In case a multiple choice gives examples instead of categories?!)

Enzymes

Hormone

Receptor

Contractile

Defensive

Transport

Storage

Structural

Structure Meets Function

Case Study: Hemoglobin

What differs?

How might this cause such a

significant change in protein

structure?

Sickle Cell Disease

Structure Meets Function

Case Study: CJD and Prions

Prions: Misfolded proteins

Can be infectious agents!

Protein Project!!! Goal:

To connect Big Ideas #1 & 3 (Evolution and continuity of proteins) to Big idea #2 (How proteins work)

Work in Pairs By Function

Your job is to find TWO examples for each function and present a poster session to connect the two examples.

Research structure meets function using primary sources and figures from primary sources.

Research evolution using a BLAST to find and compare similar protein sequences in various organisms.