provital group - citrustem orange stean cells for a younger appearance

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ANTI-AGING citrustem TM Orange stem cells Organizes the inner structure of the skin for a younger appearance www.provitalgroup.com

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Page 1: Provital Group - Citrustem Orange Stean Cells for a Younger Appearance

ANTI-AGING

citrustemTM

Orange stem cells

Organizes the inner structure of the skin for a younger appearance

www.provitalgroup.com

dougherty
Exclusive Distributor
Page 2: Provital Group - Citrustem Orange Stean Cells for a Younger Appearance

Orange stem cells. Organizes the inner structure of the skin for a younger appearance

citrustemTM

What are plant stem cells?They are undifferentiated cells that have the capacity to regenerate the whole plant.

Its use is a very sustainable way to obtain the benefits of plants because you don’t need to cultivate them, no land, no pesticides, less water is needed, and they are absolutely traceable and available at convenience.

citrustemTM, obtained from orange stem cells with anti-aging effect, is the first

launching of Provital Stem Cells Collection

Skin aging and orderAs skin ages, collagen and elastin fibers, that form the extracellular network, become disordered, unstructured and sparse.

The dermis loses density and skin shows aging signs:

The microrelief structure becomes more anisotropic resulting in a loss of softness and velvety touch.

The skin elasticity decreases and wrinkles appear.

Keeping the skin inner structure organized is essential for a younger

looking skin

citrustemTM

Organizes and redensifies the dermis structure.Restores the extracellular network improving cells adhesion.Recovers the quality of a young skin.

...The architect of skin

Orange stem cells

Page 3: Provital Group - Citrustem Orange Stean Cells for a Younger Appearance

Cell Treatment % vs. Control

P17-NHDF

100

108

111

123

Control

citrustemTM (0.03%)

citrustemTM (0.1%)

citrustemTM (0.3%)

P17-NHDF

P17-NHDF

P17-NHDF

P17-NHDF

ANTI-AGING

In vitro efficacy

All these genes are related to quality and structure of extracellular matrix:

Improvement of extracellular matrix structure

Elastin: the most important protein for good skin appearance.

Collagen VI: cell adhesion properties and a diverse range of extracellular matrix protein binding activities.

ADAM metallopeptidase: facilitates collagen function and assembly.

Gene % vs. Control

ADAM metallopeptidase with thrombospondin type 1 motif, 2

Elastin

245

251

Collagen, type VI, alpha 1 239

TGK is an essential enzyme for the epidermis. An increase in its synthesis means better assembly and organization of epidermal structures:

Stimulation of TGK production in the epidermis

Aged fibroblasts increase their proliferation capacity with citrustemTM.

The synthesis of collagen and other key elements of the extracellular matrix grow.

Stimulation of fibroblasts proliferation

citrustemTM

(0.03%)CONTROL

TGK

INC

REA

SE

VS. C

ON

TRO

L

600500400300200100

0

citrustemTM

(0.1%)citrustemTM

(0.3%)

KERATINOCYTE CULTURES

In vivo efficacy

The stratum corneum is more cohesive, with fewer scales.

The skin is smoother and recovers its velvety touch.

Desquamation regulation

Product T0 % increase

5.95

17.50*

11.6*

4.20

4.00

Placebo

citrustemTM (3%)

citrustemTM - placebo

T56

4.45

4.70

The improvement on the microrelief is the visible result of an organized and better structured dermis.

Microrelief improvement

Product T0 % increase

0.09

10.15*

10.1*

0.633

0.613

Placebo

citrustemTM (3%)

citrustemTM - placebo

T56 - T0

0.001

0.062

T56

0.634

0.675

T0 T56

With citrustemTM, the skin will recover the biological elasticity that had 12 years ago.

Biological elasticity Ur/Uf (R7) by Cutometer®

(*) statiscally significant

20 women between 41 and 55 years old, who used a 3% formula of citrustemTM, compared with a placebo formula. Applied twice a day for 56 days.

Page 4: Provital Group - Citrustem Orange Stean Cells for a Younger Appearance

Viscous liquidWhite - pale yellow color

Aqua (Water), Sodium Hydroxide (10%)E

Glyceryl Caprylate, Glyceryl UndecylenateD

Bentonite, Xantham GumAcrylates/C10-30 Alkyl Acrylate CrosspolymerSimmondsia Chinensis (Jojoba) Seed Oil

C

B CyclopentasiloxaneOleyl ErucateDimethicone, Polysilicone-11Oleth-20Tocopherol

Deion Ster. WaterGlycerinAqua (Water), Citric Acid (10%)Pentylene Glycol

A

INCI / PCPC

RECOMMENDED DOSE

SOLUBILITY

APPEARANCE

2 - 4 %

Soluble in aqueous solutions

citrustemTM, obtained from orange stem cells, organizes, restores and redensifies the dermis structure to recover the quality of a young skin

PROPERTIES

Orange stem cells. Organizes the inner structure of the skin for a younger appearance

citrustemTMANTI-AGING

cosmetic applications

Technical specifications Formulation

• Global anti-aging lines• Cosmetic products for skin rejuvenation• Anti-aging preventive cosmetics• Cellular regenerator• Intensive facial treatments• Treatment make-up

citrustemTM 72800 Ageless Restructuring Serum

Parfum (Fragrance)G

citrustemTMF

0.68

0.90

1.000.304.00

8.001.002.003.000.20

69.123.000.152.50

% (w/w)

0.15

4.00

V01-2013