psittacosis

1
1320 Bennett and Dr. D. T. Davies he had found that a z’ rise in the white count ranging from 15 to 30 thousand was almost invariable, and did not indicate the onset of toxic manifestations. As regards the future of these patients, unfortunately the reduction in the red cell count was never more than temporary, although small doses of the drug given occasionally would keep the polycythaemia withinreasonable bounds. ’Whether such treatment continued over a period of years will produce permanent damage to the liver is - a question which present experience cannot answer. THE M.R.C. AND GOOD ENGLISH. THE lot of the writer of monographs is a hard one, ,for he must have done some hard thinking, and it is not made easier by the Medical Research Council which, in our view, imposes upon him salutary rules jnspired by wisdom and experience. He is advised not to commence an article, he must begin it. He .cannot have been engaged in a study of his subject ; he has just studied it. He should not write in con- junction with a friend ; but just with him. And he should not collect a considerable amount of material our a considerable number of facts, he should only collect much or many of them. In short, restrictions. ,of liberty have been suggested, so that his manu- script will undergo a 20 per cent. reduction (or, as one might say, be one-fifth shorter) and eventually he may find himself writing quite good English without the help of the Publications Department of the Council. In the Notes upon the Preparation of Reports for Publication, which have just been issued in a revised edition after an interval of nearly nine .years, the advice remains substantially the same except for the addition of two useful appendices : one of shorter and better equivalents for long words or phrases, the other a list of abbreviations of the names of journals taken from the World List of Scientific I, Periodicals prepared under the direction of the Keeper of the Department of Printed Books in the British Museum. The Notes have not been placed - upon sale, but have been widely distributed among I research workers in medicine. The advice is not oppressive or cramping to an author’s style ; by .surrendering his liberty in non-essentials he will gain - the freedom in essentials which really matters. ’The Notes are free from the touch of irony or subtle malice which seems almost incumbent on those who ,desire to impose their own literary style on others. It was a wise author who admitted the many ways ,of writing tribal lays every single one of which was right. The Council’s censor has refrained from such banal quips as advising a would-be author to add a bibliography to his paper rather than a list of references and never to write the patient died but to say he ceased or " exitus lethalis." He might have said : If you feel the urge to write a medical article do not restrain yourself merely because you have nothing new to say and hardly know how to say it; facts and theories in medicine must be repeated again and again to drive them home. It is this sort of advice that estranges the earnest young writer and puts him off his stride when a more sympathetic mentor would be helpful in setting his feet on the narrow path of successful authorship. Comparison of the Notes of 1929 with those of 1921 reveals one alteration for which we are pro- foundly grateful. In counselling the avoidance of obscure and misleading abbreviations the Publica- tions Department has now fallen in with the continental practice of using the single letter g as an abbreviation for the gramme when standing alone or in its various compounds (kg., cg., mg.). Owing to the unfortunate similarity of the abbreviations used for the words : gramme and grain these words should always be spelt in full if there is any possibility of doubt as to which unit is specified, but the Council has seen the wisdom of adopting the symbol g. for the gramme which is slowly but surely taking its place as the unit of weight throughout the civilised world. Rather singularly in doing so the Council has gone back on its abbreviation for cubic centimetre, which in 1921 was given as c.cm. and is now c.c., an exception to the rule made, it is stated, in order to conform with the general practice. But here, again, we feel that to make the exception is to introduce disorder into the very heart of exactitude. No doubt to those who are brought up in chemical laboratories a hundred-see- see measure or a ten-see-see bottle has become a habit of mind ; to the chemist the see-see is the only unit, and the exception scarcely matters, but the biochemist has to do as much or more with the cubic millimetre, with its orthodox abbreviation. There can surely be no hardship or .ambiguity in writing c.cm. and we trust that in this particular writers of monographs will assert their individual judgment against that of the Medical Research Council. ____ PSITTACOSIS. IT is only recently that any real headway has been made in the investigation of the complex salmonella group of bacteria. It is now recognised that mankind shares infection by this group with a great variety of animals, and that the normal source of infection is the animal. A prominent member of the group, and a very widespread one, is Bacillus certrycke, which is often described under one of its very numerous synonyms. Among the rarer manifestations, at any rate in man, is the infection of parrots known as psittacosis, which seems to be transmitted from sick birds to man, and is held responsible for the recent death of Dr. D. L. Thomas, M.O.H. for Stepney. In the latter part of the last century much attention was paid to the condition, especially in Paris and in Rome; a correspondent of THE LANCET in 1899 wrote with disgust of the hundreds of deaths from this disease in imported parrots, and in 1897 we published accounts of a number of fatal human infections in Italy. In Paris, in 1892, a real epidemic was recorded, with a case mortality of 45 per cent. Nocard, in 1893, recovered an organism from the bone- marrow of an infected bird, and Gilbert and Fournier, in 1896, from a human case, which has since been known as B. psittacosis, until it was recognised as the familiar B. certrycke. So recently as July 20th of this year Dr. A. P. Thomson reported in our columns a case in which the patient appeared to suffer from atypical fever, with a positive agglutination to B. paratyphosus B. She had nursed a sick parrot, and her little niece solved the problem of her illness by suggesting that " auntie has what the parrot had." From a developing parotitis (suitably enough) an organism was recovered which was stated to agglu- tinate slightly with paratyphoid B serum. Agglu- tination, however, does not seem to have been tested with certrycke serum, and the organism was at first described as Gram-positive. Three other less well- authenticated cases were recorded in the same district. Many authorities deny that an infection is trans- mitted by parrots. To-day, at any rate, psittacosis is exceedingly rare in man, and, indeed, very uncom- mon in birds. At the London Zoo it is unknown, and it is possible that the disgraceful methods of transportation which our correspondent discussed in 1899 have to-day been abandoned, to the advantage of man and of parrot. The condition is so seldom met with that the diagnosis is scarcely one that should spring to the lips with confidence. The essentials in making out such diagnosis are a fulminating infection, with a positive agglutination to the salmonella group of organisms, the recovery of an organism of that group, and its identification with B. aertrycke. If combined with the recovery of an identical organism from the incriminated bird such a history would be convincing. It is hardly necessary to add that the risk of contracting the infection from domestic parrots is remote, though it is probably wise to beware of such birds as develop an illness soon after importation into this country.

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Page 1: PSITTACOSIS

1320

Bennett and Dr. D. T. Davies he had found that a z’

rise in the white count ranging from 15 to 30thousand was almost invariable, and did not indicatethe onset of toxic manifestations. As regards thefuture of these patients, unfortunately the reductionin the red cell count was never more than temporary,although small doses of the drug given occasionallywould keep the polycythaemia withinreasonable bounds.’Whether such treatment continued over a period ofyears will produce permanent damage to the liver is

- a question which present experience cannot answer.

THE M.R.C. AND GOOD ENGLISH.

THE lot of the writer of monographs is a hard one,,for he must have done some hard thinking, and it isnot made easier by the Medical Research Councilwhich, in our view, imposes upon him salutary rulesjnspired by wisdom and experience. He is advisednot to commence an article, he must begin it. He.cannot have been engaged in a study of his subject ;he has just studied it. He should not write in con-junction with a friend ; but just with him. And heshould not collect a considerable amount of materialour a considerable number of facts, he should onlycollect much or many of them. In short, restrictions.,of liberty have been suggested, so that his manu-script will undergo a 20 per cent. reduction (or, asone might say, be one-fifth shorter) and eventuallyhe may find himself writing quite good English withoutthe help of the Publications Department of theCouncil. In the Notes upon the Preparation ofReports for Publication, which have just been issuedin a revised edition after an interval of nearly nine.years, the advice remains substantially the sameexcept for the addition of two useful appendices :one of shorter and better equivalents for long words orphrases, the other a list of abbreviations of the namesof journals taken from the World List of Scientific I,Periodicals prepared under the direction of theKeeper of the Department of Printed Books in theBritish Museum. The Notes have not been placed- upon sale, but have been widely distributed among Iresearch workers in medicine. The advice is notoppressive or cramping to an author’s style ; by.surrendering his liberty in non-essentials he will gain- the freedom in essentials which really matters.’The Notes are free from the touch of irony or subtlemalice which seems almost incumbent on those who,desire to impose their own literary style on others.It was a wise author who admitted the many ways,of writing tribal lays every single one of which wasright. The Council’s censor has refrained from suchbanal quips as advising a would-be author to add abibliography to his paper rather than a list of referencesand never to write the patient died but to say he ceasedor

" exitus lethalis." He might have said : If you feelthe urge to write a medical article do not restrainyourself merely because you have nothing new tosay and hardly know how to say it; facts and theoriesin medicine must be repeated again and again todrive them home. It is this sort of advice thatestranges the earnest young writer and puts him offhis stride when a more sympathetic mentor wouldbe helpful in setting his feet on the narrow path ofsuccessful authorship.

Comparison of the Notes of 1929 with those of1921 reveals one alteration for which we are pro-foundly grateful. In counselling the avoidance ofobscure and misleading abbreviations the Publica-tions Department has now fallen in with the continentalpractice of using the single letter g as an abbreviationfor the gramme when standing alone or in its variouscompounds (kg., cg., mg.). Owing to the unfortunatesimilarity of the abbreviations used for the words: gramme and grain these words should always bespelt in full if there is any possibility of doubt as towhich unit is specified, but the Council has seen thewisdom of adopting the symbol g. for the grammewhich is slowly but surely taking its place as the unitof weight throughout the civilised world. Rather

singularly in doing so the Council has gone back onits abbreviation for cubic centimetre, which in 1921was given as c.cm. and is now c.c., an exception tothe rule made, it is stated, in order to conform withthe general practice. But here, again, we feel that tomake the exception is to introduce disorder into thevery heart of exactitude. No doubt to those who arebrought up in chemical laboratories a hundred-see-see measure or a ten-see-see bottle has become a

habit of mind ; to the chemist the see-see is the onlyunit, and the exception scarcely matters, but thebiochemist has to do as much or more with thecubic millimetre, with its orthodox abbreviation.There can surely be no hardship or .ambiguity inwriting c.cm. and we trust that in this particularwriters of monographs will assert their individualjudgment against that of the Medical ResearchCouncil.

____

PSITTACOSIS.

IT is only recently that any real headway has beenmade in the investigation of the complex salmonellagroup of bacteria. It is now recognised that mankindshares infection by this group with a great variety ofanimals, and that the normal source of infection isthe animal. A prominent member of the group, anda very widespread one, is Bacillus certrycke, which isoften described under one of its very numeroussynonyms. Among the rarer manifestations, at anyrate in man, is the infection of parrots known aspsittacosis, which seems to be transmitted from sickbirds to man, and is held responsible for the recentdeath of Dr. D. L. Thomas, M.O.H. for Stepney.

In the latter part of the last century much attentionwas paid to the condition, especially in Paris and inRome; a correspondent of THE LANCET in 1899wrote with disgust of the hundreds of deaths fromthis disease in imported parrots, and in 1897 wepublished accounts of a number of fatal humaninfections in Italy. In Paris, in 1892, a real epidemicwas recorded, with a case mortality of 45 per cent.Nocard, in 1893, recovered an organism from the bone-marrow of an infected bird, and Gilbert and Fournier,in 1896, from a human case, which has since beenknown as B. psittacosis, until it was recognised asthe familiar B. certrycke. So recently as July 20th ofthis year Dr. A. P. Thomson reported in our columnsa case in which the patient appeared to suffer fromatypical fever, with a positive agglutination toB. paratyphosus B. She had nursed a sick parrot, andher little niece solved the problem of her illness bysuggesting that " auntie has what the parrot had."From a developing parotitis (suitably enough) anorganism was recovered which was stated to agglu-tinate slightly with paratyphoid B serum. Agglu-tination, however, does not seem to have been testedwith certrycke serum, and the organism was at firstdescribed as Gram-positive. Three other less well-authenticated cases were recorded in the same

district.Many authorities deny that an infection is trans-

mitted by parrots. To-day, at any rate, psittacosisis exceedingly rare in man, and, indeed, very uncom-mon in birds. At the London Zoo it is unknown,and it is possible that the disgraceful methods oftransportation which our correspondent discussed in1899 have to-day been abandoned, to the advantageof man and of parrot. The condition is so seldom metwith that the diagnosis is scarcely one that shouldspring to the lips with confidence. The essentialsin making out such diagnosis are a fulminatinginfection, with a positive agglutination to thesalmonella group of organisms, the recovery of anorganism of that group, and its identification withB. aertrycke. If combined with the recovery of anidentical organism from the incriminated bird sucha history would be convincing. It is hardly necessaryto add that the risk of contracting the infection fromdomestic parrots is remote, though it is probablywise to beware of such birds as develop an illnesssoon after importation into this country.