92 BOOK REVIEWS

resting tremor in the left extremities and head with diabetes insipidus and oculomotor dysfunction, it is unclear that the patient actually had parkinsonism since no mention of rigidity or bradykinesia is present and since the pathologic description did not include basal ganglia involvement. The title does not allude to the case being that of parkinsonism, and in an attempt to locate and review the article, we found the journal as referenced is not available in North American libraries.

These cases, the study by Heyde (7), and the personal autopsy experience of Dr. Jell- inger substantiate three points that we made in our article (6). First, trauma does not cause Parkinson’s disease. Second, a parkinsonian syndrome may result from significant head trauma. This syndrome is typically associated with other neurologic and psychiatric signs and symptoms. Third, despite the relatively frequent incidence of head trauma, this par- kinsonian syndrome is exceedingly rare. Heyde (7) observed that among 683 cases of head trauma examined, only 6 (0.9 %) had a parkinsonian syndrome; Jellinger noted in his letter that of 520 parkinsonian patients evaluated, only 3 (0.6 %) were caused by trauma, and Crouzon and Justin-Besancon (8) claimed that they had seen “hundreds of concussion cases a long time after the wound and I never found even one case of a parkinson syndrome.” These facts must remain clearly understood by physicians, especially in the current litigious climate.

Stewart A. Factor Juan Sanchez-Ramos

William J. Weiner University of Miami,

Miami, Florida 33101

REFERENCES

1 . Eisenlohr C. Zur Diagnose der Vierhiigelerkrankungen. Jahrbuch Hamburg Staatskrank

2. Jentzer A, De Morsier G . Hemiparkinsonism droit postraumatique avec lesion du noyau rouge et

3. De Morsier G . Parkinsonism consecutif B une lesion traumatique du noyau rouge et du locus niger.

4. Ziilch KJ. Pathologische Anatomie, Physiopathologie und pathomechanismen des SchSdelhirn-

5. Bruetsch WL, De Armond M. The parkinsonian syndrome due to trauma. A clinico-anatomical

6. Factor SA, Sanchez-Ramos J, Weiner WJ. Trauma as an etiology of parkinsonism: a historical

7. Heyde W. Zur frage des traumatischen parkinsonismus, zugleich ein Beitrag zur Kenntnis ex-

8. Crouzon 0, Justin-Besancon L. Le parkinsonisme traumatique. Presse Med 1929;37: 1325-7.

1889;1:71.

du locus niger. Schweiz Arch Neurol 1947;60:388.

Psychiatry Neurol 1960;13960-84.

traumas. Bull Soc Sci Med Grand Duche Luxemb 1969;106: 153-21 1 .

study. J New Ment Dis 1935;81:531-46.

review of the concept. Movement Disorders 1988;3:3&6.

trapyramidal -motorischer St6rungen nach Hirnverletzungen. Arch Psychiatry 1932;97:60043.

Book Reviews

Psychopharmacology: The Third Generation of Progress. Herbert Y . Meltzer, (ed) Raven Press, New York, 1987.

The American College of Neuropsychopharmacology (ACNP) is to be commended for bringing forth the third edition of this important reference work. The first edition, published

Movement Disorders, Vol. 4 , No. 1. 1989 Movement Disorders, Vol. 4 , No. I , 1989

BOOK REVIEWS 93

in 1%8, represented the proceedings of the sixth annual meeting of the ACNP. The second edition, Psychopharmacology: A Generation of Progress, published in 1976, became a widely cited reference in basic neuroscience, psychiatry, and neurology, and this volume promises to be the same. It contains 184 chapters written by 271 contributors in 1,840 pages. It is divided into three major sections: Basic Neurobiology (J. T. Coyle and I. J. Kopin, associate editors), Biological Psychiatry (W. E. Bunney, Jr. and K. L. Davis), and Clinical Psychopharmacology (C. R. Schuster, R. I. Shader, and G. M. Simpson).

The scope and depth of the volume in the clinical aspects and the scientific foundations of psychiatry leave no question that this will be a highly useful reference work for prac- tising psychiatrists, research psychiatrists, and psychopharmacologists. As a neurologist, I reviewed the work with regard to its potential usefulness for members of the neuroscience community outside of psychiatry and psychopharmacology. For all neuroscientists, this volume is a valuable resource, owing particularly to the strength of the basic neurobiology section. There are 48 chapters in this section, covering the neuroanatomy and neurochem- istry of the classic neurotransmitter systems; neurotransmitter receptors and their heter- ogeneity; neurotoxins in animal models and human disease; and the molecular biology, chemistry, and anatomy of the neuropeptides. To have this range of neuroscience updated succinctly and definitively by established authorities in each area and collected in a single volume provides a valuable resource indeed.

The neurologist with an interest in movement disorders has much to find in this book. Within the basic neurobiology section, chapters of potential interest include those devoted to muscarinic cholinergic and dopaminergic receptor heterogeneity, neural transplantation, and MPTP-induced parkinsonism. Also of potential interest are the chapters devoted to the design of clinical trials of drugs, the design and validation of clinical rating scales, and the pharmacokinetics of centrally acting agents. Two movement disorders related to psycho- tropics, tardive dyskinesia and neuroleptic malignant syndrome, are reviewed thoroughly but concisely. My one disappointment here was in the lack of coverage of other psycho- tropic drug-induced movement disorders including acute dystonia, akathisia, and parkin- sonism. Perhaps the editorial decision to limit the contents to a single volume led to the exclusion of subjects in which there is less news to report. Nevertheless, there is enough information here to make this a highly valued source for the next generation, at least.

Robert E. Burke, M.D. Neurological Institute of New York,

Columbia Universio College of Physicians and Surgeons,

New York, NY

Charcot, the Clinician: The Tuesday Lessons: Excerpts from Nine Case Presentations on General Neurology Delivered at the SalpPtrikre Hospital in 1887-88 by Jean-Martin Charcot. Translated with Commentary by Christopher G. Goetz. Raven Press, New York, 223, illustrated, $56.00, 1987.

As all neurologists know, Jean-Martin Charcot, professor of neurology at SalpCtrikre in Paris from 1862 until his death in 1893 at age 67, was one of the leading clinical neurologists of his day and is considered by many the greatest of all time. Charcot meticulously exam- ined thousands of patients at the huge hospital. By combining his clinical evaluations with postmortem findings, he gradually was able to piece together a large number of neurologic facts into syndromes and disease states previously unrecognized as single entities or con- fused with other disorders having similar symptoms and signs. Famous examples include

Movement Disorders, Vol. 4, No. 1. 1989