MOLECULAR BIOLOGY

SIMÓN RESTREPO ARISMENDYMedicine Student

UPB

Scientists Identify Molecular Basis for DNA Breakage, a Hallmark of Cancer Cells

 Targeting PTEN May Prevent Skin Cancer

 

FOLDING

FOLDING

INTRODUCTION

Sounds like an easy thing, but it´s a very complex molecular process

Even a tiny mistake in the DNA replication can cause terrible diseas like

cancer

TARGETING PTEN MAY PREVENT CANCERScienceDaily (july26, 2011)

TARGETING PTEN MAY PREVENT CANCER

Non-melanome skin cancer is the most common cancer in the United States.

PTEN proteins promote cellular repair

TARGETING PTEN MAY PREVENT CANCER

Cells with low PTEN protein were more likely to hace UVB-induced skin cancers.

Reduced levels of PTEN proteins could lead to cancer and tumor progression.

TARGETING PTEN MAY PREVENT CANCER

Increasing PTEN protein activity could reduce skin

cancer and tumor progression.

OBSERVATION

This study, has made a breakthrough the

understanding the PTEN protein function and the way to prevent skin cancer and

tumor progression, which is a huge and a really important

step in the war against oncology diseases.

SCIENTIST IDENTIFY MOLECULAR BASIS FOR

DNA BREAKAGE, A HALLMARK OF CANCER

CELLSSCIENCEDAILY (JULY 19, 2011)

Scientist identify Molecular Basis for DNA Breakage, A Hallmark Of Cancer

Cells

The DNA encodes the entire genetic information required for building the proteins of

the cell.

Under stress condition, DNA usually breaks.

Scientist identify Molecular Basis for DNA Breakage, A Hallmark Of Cancer Cells

DNA breaks leads in an uncontrolled cell division and

at the end in a cancer development

The study shed a light on the regulation of DNA replication

along the fragile sites

Scientist Identify Molecular Basis for DNA Breakage, A Hallmark Of Cancer

Cells

Fragile sites, where the DNA breakage begins, is a site that slow and also can stop DNA

replication.

OPINION

 

This study, has made a breakthrough the

understanding the PTEN protein function and the way to prevent skin cancer and tumor progression, which is a huge and a really important step in

the war against oncology diseases.

Medical Utility

Medical Utility

.

Both studies could let the scientist have more tool to keep investingation around more genetic troubles that

could end in cancer

Medical Utility

Founding cancer genetic causes and all the

molecular process that increase posibilty of

developing this diseas, could end in some

nutrition regim that gives the posibilty to prevent some specific cancer.

Medical utility

Scientist could develop better treatments or even a cure for

cancer.

BIBLIOGRAPHY

1. Targetin PTEN may prevent skin Cancer. American Association for Cancer Research . 2011, July 26. ScienceDaily [online]. Retrieved August 6, 2011, from http://www.sciencedaily.com/releases/2011/07/110726132351.htm

2.  Scientists identify molecular basis for DNA breakage, a hallmark of cancer cells.. Hebrew University of Jerusalem. 2011, July 19. ScienceDaily [online]. Retrieved August 6, 2011, from http://www.sciencedaily.com/releases/2011/07/110719094023.htm

3.  Martinez S Lina María. Biologia Molecular. 6 ed.

Medellin. UPB. Fac Medicina. 2011, 74-75p 

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