PulmonaryPathology

An Atlas and Text

THIRD EDITION

Editor-in-Chief

Philip T. Cagle, MDProfessor, Department of Pathology and Genomic Medicine, HoustonMethodist Hospital, Houston, Texas Associate Editors

Timothy C. Allen, MD, JDProfessor and Chair, Department of Pathology, University of MississippiMedical Center, Jackson, Mississippi

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Mary Beth Beasley, MDProfessor, Department of Pathology, Icahn School of Medicine at MountSinai, New York, New York

Alain Borczuk, MDProfessor of Pathology, Department of Pathology, NewYork-PresbyterianHospital/Weill Cornell Medical Center, New York, New York

Yasmeen M. Butt, MDAssistant Professor, Department of Pathology, University of TexasSouthwestern Medical Center, Dallas, Texas

Sanja Dacic, MD, PhDProfessor of Pathology, Department of Pathology, University ofPittsburgh, Staff Pathologist, Department of Pathology, University ofPittsburgh Medical Center, Pittsburgh, Pennsylvania

Aliya N. Husain, MDProfessor, Department of Pathology, University of Chicago, Chicago,Illinois

Brandon T. Larsen, MD, PhDAssistant Professor, Department of Laboratory Medicine and Pathology,Mayo Clinic School of Medicine, Senior Associate Consultant,Department of Laboratory Medicine and Pathology, Mayo Clinic Arizona,

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Scottsdale, Arizona

Ross A. Miller, MDAssistant Professor, Pathologist, Department of Pathology and GenomicMedicine, Houston Methodist Hospital, Houston, Texas

Mari Mino-Kenudson, MDAssociate Professor, Department of Pathology, Harvard Medical School,Director, Pulmonary Pathology Service, Department of Pathology,Massachusetts General Hospital, Boston, Massachusetts

Sergio Pina-Oviedo, MDAssistant Professor, Department of Pathology, University of Arkansas forMedical Sciences, Little Rock, Arkansas

Kirtee Raparia, MDAssociate Pathologist, Department of Pathology, Kaiser Permanente SantaClara Medical Center, Santa Clara, California

Natasha Rekhtman, MD, PhDAssociate Attending Pathologist, Department of Pathology, MemorialSloan Kettering Cancer Center, New York, New York

Anja C. Roden, MDAssociate Professor, Consultant, Department of Laboratory Medicine and

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Pathology, Mayo Clinic, Rochester, Minnesota

Sinchita Roy-Chowdhuri, MD, PhDAssistant Professor, Department of Pathology, University of Texas MDAnderson 
 Cancer Cente r, Hou st on, Te xas

Lynette M. Sholl, MDAssociate Pathologist, Department of Pathology, Brigham and Women’sFaulkner Hospital, Boston, Massachusetts

Maxwell L. Smith, MDAssociate Professor, Department of Laboratory Medicine and Pathology,Mayo Clinic School of Medicine, Consultant, Department of LaboratoryMedicine and Pathology, Mayo Clinic Arizona, Scottsdale, Arizona

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Table of Contents

Cover image

Title page

Copyright

Dedication

Contributing Authors

Preface to the Third Edition

Preface to the First Edition

Acknowledgments

Section 1 Normal Cytology and Histology Sinchita Roy-Chowdhuri

Chapter 1 Bronchus

Chapter 2 Bronchioles and Alveolar Ducts

Chapter 3 Blood Vessels and Lymphatics

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Chapter 4 Alveoli

Chapter 5 Pleura

Chapter 6 Normal Cytology of the Lung and Pleura

Section 2 Artifacts and Age-Related Changes Sinchita Roy-Chowdhuri

Chapter 7 Procedural and Laboratory Artifacts

Chapter 8 Reactive Changes, Nonspecific Findings, and Age-RelatedChanges

Chapter 9 Noncellular Structures

Section 3 Malignant Neoplasms Mari Mino-Kenudson, Sergio Pina-Oviedo, Sanja Dacic, Timothy C. Allen, Ross A. Miller, Philip T. Cagle

Chapter 10 Adenocarcinoma

Part 1. Lepidic Adenocarcinoma

Part 2. Acinar Adenocarcinoma

Part 3. Papillary Adenocarcinoma

Part 4. Micropapillary Adenocarcinoma

Part 5. Solid Adenocarcinoma

Part 6. Invasive Mucinous Adenocarcinoma

Part 7. Colloid Adenocarcinoma

Part 8. Fetal Adenocarcinoma

Part 9. Enteric Adenocarcinoma

Part 10. Signet Ring and Clear Cell Features

Chapter 11 Squamous-Cell Carcinoma

Part 1. Keratinizing Squamous-Cell Carcinoma

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Part 2. Nonkeratinizing Squamous-Cell Carcinoma

Part 3. Basaloid Squamous-Cell Carcinoma

Chapter 12 Adenosquamous Carcinoma

Chapter 13 Large-Cell Carcinoma

Chapter 14 Neuroendocrine Carcinomas

Part 1. Small-Cell Carcinoma

Part 2. Carcinoid Tumor

Part 3. Atypical Carcinoid Tumor

Part 4. Large-Cell Neuroendocrine Carcinoma

Chapter 15 Sarcomatoid Carcinomas

Part 1. Carcinosarcoma

Part 2. Pulmonary Blastoma

Part 3. Pleomorphic Carcinoma

Chapter 16 Salivary Gland–Type Cancers

Part 1. Adenoid Cystic Carcinoma

Part 2. Mucoepidermoid Carcinoma

Part 3. Epithelial–Myoepithelial Carcinoma

Chapter 17 Lymphoepithelioma-Like Carcinoma

Chapter 18 NUT Carcinoma

Chapter 19 Primary Pulmonary Sarcomas

Part 1. Inflammatory Myofibroblastic Tumor

Part 2. Pleuropulmonary Blastoma

Part 3. Epithelioid Hemangioendothelioma

Part 4. Kaposi Sarcoma

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Part 5. Synovial Sarcoma

Part 6. Malignant Solitary Fibrous Tumor

Part 7. Intimal Sarcoma

Part 8. SMARCA4-Deficient Thoracic Sarcoma

Part 9. Primary Pulmonary Myxoid Sarcoma with EWSR1-CREB1 Translocation

Chapter 20 Secondary Pulmonary Sarcomas

Part 1. Leiomyosarcoma

Part 2. Angiosarcoma

Part 3. Osteosarcoma

Part 4. Chondrosarcoma

Part 5. Liposarcoma

Part 6. Malignant Peripheral Nerve Sheath Tumor

Part 7. Rhabdomyosarcoma

Part 8. Undifferentiated Soft Tissue Sarcoma

Part 9. Ewing Sarcoma

Chapter 21 Other Pulmonary Sarcomas

Part 1. Alveolar Soft Part Sarcoma

Part 2. Clear Cell Sarcoma

Part 3. Desmoplastic Small Round Cell Tumor

Part 4. Extrarenal Rhabdoid Tumor

Part 5. Chordoma

Part 6. Extraskeletal Myxoid Chondrosarcoma

Chapter 22 Pulmonary B-Cell Lymphomas

Part 1. Primary and Secondary Lung Involvement

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Subpart 1.1. Extranodal Marginal Zone Lymphoma (MZL) of theMucosa-Associated Lymphoid Tissue (MALT Lymphoma)

Subpart 1.2. Diffuse Large B-Cell Lymphoma (DLBCL)

Subpart 1.3. Lymphomatoid Granulomatosis (LyG)

Part 2. Systemic B-Cell Lymphomas with Secondary LungInvolvement

Subpart 2.1. Small B-Cell Lymphomas

Subpart 2.2. Other B-Cell Lymphomas

Chapter 23 Pulmonary Classical Hodgkin Lymphoma

Chapter 24 Pulmonary T-Cell Lymphomas

Part 1. Peripheral T-cell Lymphoma, NOS

Part 2. Systemic T-cell Lymphomas with Secondary LungInvolvement

Subpart 2.1. Pulmonary (Visceral) Involvement by MycosisFungoides/Sézary Syndrome

Subpart 2.2. Pulmonary Anaplastic Large-Cell Lymphoma (ALCL)

Chapter 25 Pulmonary Plasma Cell Neoplasms and RelatedConditions

Part 1. Primary Pulmonary Plasma Cell Neoplasms

Part 2. Systemic Plasma Cell Neoplasm with Secondary LungInvolvement

Chapter 26 Other Systemic Hematolymphoid Neoplasms withSecondary Lung Involvement

Part 1. Acute Leukemia or Myeloproliferative Neoplasms

Subpart 1.1. Acute Leukemia

Subpart 1.2. Myeloproliferative Neoplasms

Chapter 27 Other Neoplasms of the Lung

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Part 1. Malignant Melanoma

Part 2. Pleuropulmonary Thymoma

Part 3. Malignant Germ Cell Tumors

Part 4. Lymphangioleiomyomatosis

Part 5. Ciliated Muconodular Papillary Tumor of the Lung

Chapter 28 Metaplastic, Dysplastic, and Premalignant Lesions

Part 1. Atypical Adenomatous Hyperplasia

Part 2. Adenocarcinoma In Situ

Part 3. Minimally Invasive Adenocarcinoma

Part 4. Squamous Metaplasia, Squamous Dysplasia, andSquamous Carcinoma In Situ

Subpart 4.1. Squamous Metaplasia

Subpart 4.2. Squamous Dysplasia

Subpart 4.3. Squamous Carcinoma In Situ

Part 5. Squamous Papilloma and Papillomatosis

Subpart 5.1. Glandular Papilloma and Mixed Squamous andGlandular Papilloma

Part 6. Diffuse Idiopathic Pulmonary Neuroendocrine-CellHyperplasia (DIPNECH)

Chapter 29 Neoplasms of the Pleura

Part 1. Diffuse Malignant Mesothelioma

Part 2. Localized Malignant Mesothelioma

Part 3. Well-Differentiated Papillary Mesothelioma

Part 4. Synovial Sarcoma

Part 5. Vascular Sarcomas

Part 6. Malignant SFT

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Part 7. Pseudomesotheliomatous Carcinoma

Part 8. Calcifying Fibrous Tumor

Part 9. Desmoplastic Small Round Cell Tumor

Section 4 Benign Neoplasms Natasha Rekhtman

Chapter 30 Pulmonary Hamartoma

Chapter 31 Pulmonary Chondroma

Chapter 32 Solitary Fibrous Tumor

Chapter 33 Desmoid-Type Fibromatosis

Chapter 34 Carcinoid Tumorlet

Chapter 35 Pulmonary Meningothelial Nodule

Chapter 36 Sclerosing Pneumocytoma

Chapter 37 Alveolar Adenoma

Chapter 38 Papillary Adenoma

Chapter 39 Mucous Gland Adenoma

Chapter 40 Oncocytoma

Chapter 41 Pleomorphic Adenoma

Chapter 42 Multifocal Multinodular Pneumocyte Hyperplasia

Chapter 43 PEComa

Chapter 44 Glomus Tumor

Chapter 45 Giant Cell Tumor

Chapter 46 Meningioma

Section 5 Pulmonary Histiocytic Proliferations Anja C. Roden

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Chapter 47 Pulmonary Langerhans-Cell Histiocytosis

Chapter 48 Erdheim–Chester Disease

Chapter 49 Rosai–Dorfman Disease

Chapter 50 Other Pulmonary Histiocytic Proliferations

Section 6 Benign and Borderline Lymphoid Proliferations KirteeRaparia

Chapter 51 Follicular Bronchiolitis and Follicular Bronchitis

Chapter 52 Nodular Lymphoid Hyperplasia

Chapter 53 Lymphoid Interstitial Pneumonia

Section 7 Focal Lesions Ross A. Miller

Chapter 54 Apical Caps

Chapter 55 Focal Scars

Chapter 56 Pulmonary Ossification

Chapter 57 Intrapulmonary Lymph Nodes

Chapter 58 Rounded Atelectasis

Chapter 59 Amyloidosis (Nodular and Tracheobronchial)

Section 8 Granulomatous Diseases Yasmeen M. Butt

Chapter 60 Infectious Granulomas

Part 1. Mycobacterium

Part 2. Fungi

Part 3. Parasites

Chapter 61 Bronchocentric Granulomatosis

Chapter 62 Pulmonary Hyalinizing Granuloma

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Chapter 63 Sarcoidosis

Chapter 64 Berylliosis

Chapter 65 Sarcoid-Like Reaction

Chapter 66 Necrotizing Sarcoid Granulomatosis

Chapter 67 Foreign-Body Granulomas

Part 1. Intravenous Drug Abuse

Part 2. Aspiration

Part 3. Other Foreign-Body Reactions

Chapter 68 Nodules Resembling Granulomas

Part 1. Rheumatoid Nodules

Part 2. Malakoplakia

Section 9 Diffuse Pulmonary Hemorrhage Lynette M. Sholl

Chapter 69 Alveolar Hemorrhage without Vasculitis

Part 1. Artifactual (Procedural) Hemorrhage/Hemorrhage in theAbsence of Other Histologic Abnormalities

Part 2. Hemorrhage as a Secondary Finding (Infection,Malignancy)

Part 3. Hemorrhage with Diffuse Alveolar Damage

Part 4. Passive Congestion

Part 5. Arteriovenous Malformations

Part 6. Idiopathic Pulmonary Hemosiderosis

Chapter 70 Alveolar Hemorrhage with Vasculitis

Part 1. Vasculitis in Collagen Vascular Diseases

Part 2. Anti–Glomerular Basement Membrane Antibody Disease(Goodpasture Syndrome)

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Part 3. Granulomatosis with Polyangiitis (Formerly WegenerGranulomatosis)

Part 4. Eosinophilic Granulomatosis with Polyangiitis (FormerlyChurg–Strauss Syndrome)

Part 5. Antiphospholipid Syndrome

Part 6. Microscopic Polyangiitis

Section 10 Pulmonary Hypertension and Embolic Disease AlainBorczuk

Chapter 71 Pulmonary Arterial Hypertension

Chapter 72 Pulmonary Veno-Occlusive Disease

Chapter 73 Pulmonary Capillary Hemangiomatosis

Chapter 74 Pulmonary Hypertension Associated with Lung Diseaseand/or Hypoxemia

Chapter 75 Thromboembolic Disease—Acute and Chronic

Part 1. Thromboemboli

Part 2. Foreign-Body Emboli

Part 3. Fat Emboli

Part 4. Amniotic Fluid Embolism

Part 5. Tumor Emboli

Part 6. Parasitic Emboli

Part 7. Bone Marrow Emboli

Chapter 76 Pulmonary Infarct

Chapter 77 Pulmonary Hypertension with Unclear or MultifactorialMechanisms

Section 11 Large Airways Ross A. Miller

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Chapter 78 Bronchiectasis

Chapter 79 Middle Lobe Syndrome

Chapter 80 Tracheobronchopathia Osteochondroplastica

Chapter 81 Asthma

Chapter 82 Allergic Bronchopulmonary Aspergillosis

Section 12 Small Airways Sanja Dacic

Chapter 83 Bronchiolar and Peribronchiolar Inflammation, Fibrosis, andMetaplasia

Chapter 84 Lobular Pneumonia

Chapter 85 Organizing Pneumonia

Chapter 86 Constrictive Bronchiolitis

Chapter 87 Respiratory Bronchiolitis and Membranous Bronchiolitis

Chapter 88 Follicular Bronchiolitis

Chapter 89 Diffuse Panbronchiolitis

Chapter 90 Small Airways and Inorganic Dust

Section 13 Alveolar Infiltrates Mary Beth Beasley

Chapter 91 Acute Pneumonia

Chapter 92 Pulmonary Edema

Chapter 93 Diffuse Alveolar Damage

Chapter 94 Acute Fibrinous and Organizing Pneumonia

Chapter 95 Lipoid Pneumonia

Chapter 96 Eosinophilic Pneumonia

Chapter 97 Desquamative Interstitial Pneumonia (DIP)-Like Pattern

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Chapter 98 Pulmonary Alveolar Proteinosis

Section 14 Tobacco-Related Diseases Lynette M. Sholl

Chapter 99 Emphysema

Part 1. Placental Transmogrification of the Lung

Chapter 100 Chronic Bronchitis

Chapter 101 Respiratory Bronchiolitis

Chapter 102 Respiratory Bronchiolitis-Interstitial LungDisease/Desquamative Interstitial Pneumonia

Part 1. Pulmonary Langerhans Cell Histiocytosis

Chapter 103 Smoking-Related Interstitial Fibrosis

Section 15 Diffuse Interstitial Lung Diseases Maxwell L. Smith

Chapter 104 Hypersensitivity Pneumonitis

Chapter 105 Hot Tub Lung

Chapter 106 Flock Lung

Chapter 107 Airway-Centered Fibrosis

Chapter 108 Diffuse Alveolar Septal Amyloidosis

Chapter 109 Honeycomb Lung

Chapter 110 Lung Disease in Inflammatory Bowel Disease

Chapter 111 Common Variable Immunodeficiency Disorders/Granulomatous–Lymphocytic Interstitial Lung Disease(CVID/GLILD)–Associated Lung Disease

Chapter 112 Chronic Aspiration Bronchiolitis

Chapter 113 IgG4-Related Pulmonary Disease

Chapter 114 Diffuse Meningotheliomatosis

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Section 16 Idiopathic Interstitial Pneumonias Kirtee Raparia

Chapter 115 Acute Interstitial Pneumonia

Chapter 116 Usual Interstitial Pneumonia

Chapter 117 Nonspecific Interstitial Pneumonia

Chapter 118 Cryptogenic Organizing Pneumonia

Chapter 119 Idiopathic Pleuroparenchymal Fibroelastosis

Section 17 Specific Infectious Agents Alain Borczuk

Chapter 120 Viruses

Part 1. Cytomegalovirus

Part 2. Herpes Simplex Virus

Part 3. Varicella Zoster Virus

Part 4. Adenovirus

Part 5. Influenza

Part 6. Parainfluenza

Part 7. Measles

Part 8. Respiratory Syncytial Virus

Part 9. Hantavirus

Chapter 121 Bacteria

Part 1. Streptococcus

Part 2. Staphylococcus

Part 3. Klebsiella

Part 4. Pseudomonas

Part 5. Legionella

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Part 6. Actinomyces

Part 7. Nocardia

Part 8. Mycoplasma

Part 9. Coxiella burneti

Part 10. Rhodococcus

Chapter 122 Mycobacteria

Chapter 123 Fungi

Part 1. Aspergillus

Part 2. Mucorales

Part 3. Pneumocystis

Part 4. Histoplasma

Part 5. Cryptococcus

Part 6. Coccidioides

Part 7. Paracoccidioides

Part 8. Blastomycosis

Part 9. Candida

Part 10. Phaeohyphomycosis

Chapter 124 Parasites

Part 1. Strongyloides

Part 2. Dirofilaria

Part 3. Toxoplasma

Part 4. Acanthamoeba

Part 5. Paragonimus

Part 6. Schistosoma

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Part 7. Leishmania

Part 8. Echinococcus

Section 18 Transplant-Related Pathology Aliya N. Husain

Chapter 125 Acute Lung Transplant Rejection

Chapter 126 Chronic Lung Allograft Dysfunction

Chapter 127 Antibody-Mediated Lung Transplant Rejection

Chapter 128 Anastomotic Complications

Chapter 129 Transplant-Related Infections

Chapter 130 Primary Graft Dysfunction

Chapter 131 Organizing Pneumonia in the Transplanted Lung

Chapter 132 Other Lung Transplant–Related Pathology

Chapter 133 Posttransplant Lymphoproliferative Disorders

Chapter 134 Lung Pathology in Transplantation of Other Organs

Section 19 Lung Pathology in Collagen Vascular Diseases LynetteM. Sholl

Chapter 135 Lung Pathology in Collagen Vascular Diseases

Section 20 Therapeutic Drug Reactions and RadiationEffects Brandon T. Larsen

Chapter 136 Amiodarone

Chapter 137 Methotrexate

Chapter 138 Nitrofurantoin

Chapter 139 Fenfluramine–Phentermine (“Fen–Phen”)

Chapter 140 Targeted Molecular Therapies

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Chapter 141 Other Drugs

Chapter 142 Radiation Pneumonitis

Section 21 Pneumoconioses Timothy C. Allen

Chapter 143 Asbestosis

Chapter 144 Silicosis

Chapter 145 Silicatosis

Chapter 146 Mixed Pneumoconiosis and Mixed-Dust Pneumoconiosis

Chapter 147 Coal Worker’s Pneumoconiosis

Chapter 148 Giant-Cell Interstitial Pneumonia/Hard-MetalPneumoconiosis

Chapter 149 Siderosis

Chapter 150 Aluminosis

Section 22 Metabolic Disorders/Storage Diseases Timothy C. Allen

Chapter 151 Pulmonary Alveolar Microlithiasis

Chapter 152 Pulmonary Metastatic Calcification/Calcinosis

Chapter 153 Storage Diseases

Section 23 Nonneoplastic Lesions of the Pleura Ross A. Miller

Chapter 154 Fibrinous and Fibrous Pleuritis

Chapter 155 Specific Forms of Pleuritis

Chapter 156 Eosinophilic Pseudovasculitis

Chapter 157 Reactive Mesothelial Hyperplasia

Chapter 158 Endometriosis

Chapter 159 Splenosis

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Chapter 160 Ectopic Hepatic Tissue

Chapter 161 Nodular Histiocytic Hyperplasia

Section 24 Pediatric Pulmonary Pathology Aliya N. Husain

Chapter 162 Congenital Pulmonary Airway Malformation Type 1

Chapter 163 Developmental Abnormalities Associated with BronchialObstruction

Chapter 164 Congenital Pulmonary Airway Malformation Type 3

Chapter 165 Pulmonary Sequestration

Chapter 166 Bronchogenic Cyst

Chapter 167 Pulmonary Growth Abnormalities

Chapter 168 Neuroendocrine Hyperplasia of Infancy

Chapter 169 Pulmonary Interstitial Glycogenosis

Chapter 170 Genetic Disorders of Surfactant Metabolism

Chapter 171 Cystic Fibrosis

Chapter 172 Primary Ciliary Dyskinesia

Chapter 173 Chronic Granulomatous Disease

Chapter 174 Alveolar Capillary Dysplasia with Misalignment ofPulmonary Veins

Chapter 175 Acinar Dysplasia

Chapter 176 Complications of Prematurity

Chapter 177 Meconium Aspiration

Chapter 178 Lymphatic Disorders

Chapter 179 Juvenile Respiratory Papillomatosis

Chapter 180 Pleuropulmonary Blastoma

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Chapter 181 Other Primary Lung Tumors in Children

Chapter 182 Pediatric Tumors Metastatic to the Lung

Bibliography

Index

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CopyrightSenior Acquisitions Editor: Ryan ShawDevelopment Editor: Sean McGuireEditorial Coordinator: Jennifer DiRiccoMarketing Manager: Rachel Mante LeungProduction Project Manager: Joan SinclairDesign Coordinator: Holly McLaughlinManufacturing Coordinator: Beth WelshPrepress Vendor: TNQ Books and Journals

Third edition

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Library of Congress Cataloging-in-Publication Data

Names: Cagle, Philip T., editor.Title: Pulmonary pathology : an atlas and text/editor-in-chief, PhilipT. Cagle ; associate editors, Timothy Craig Allen [and 15 others].Other titles: Color atlas and text of pulmonary pathology.Description: Third edition. | Philadelphia : Wolters Kluwer, [2019] |Preceded by Color atlas and text of pulmonary pathology / editor-in-chief, Philip T. Cagle ; associate editors, Timothy C. Allen ... [etal.]. c2008. | Includes bibliographical references and index.Identifiers: LCCN 2017058337 | ISBN 9781496346094 (hardback)Subjects: | MESH: Lung Diseases–pathology | AtlasesClassification: LCC RC756 | NLM WF 17 | DDC 616.2/407–dc23 LCrecord available at https://lccn.loc.gov/2017058337

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accompanying each drug to verify, among other things, conditionsof use, warnings, and side effects and identify any changes indosage schedule or contraindications, particularly if the medicationto be administered is new, is infrequently used, or has a narrowtherapeutic range. To the maximum extent permitted underapplicable law, no responsibility is assumed by the publisher forany injury and/or damage to persons or property, as a matter ofproducts liability, negligence law or otherwise, or from anyreference to or use by any person of this work.

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Dedication

To S. Donald Greenberg, MD

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Contributing AuthorsTimothy C. Allen, MD, JD, Professor and Chair, Department ofPathology, University of Mississippi Medical Center, Jackson,Mississippi

Richard Attanoos, MD, Consultant Pathologist, Department ofCellular Pathology, University Hospital of Wales, Cardiff, Wales,United Kingdom

Marcelo L. Balancin, MD, PhD(c), Consulting Pathologist,Department of Surgical Pathology, Diagnostika-Institute HermesPardini, São Paulo, Brazil

Roberto Barrios, MD, Professor of Pathology, Department ofPathology and Genomic Medicine, Weill Cornell Medical College ofCornell University, Houston Methodist Hospital, Houston, Texas

Mary Beth Beasley, MD, Professor, Department of Pathology,Icahn School of Medicine at Mount Sinai, New York, New York

Carlos Bedrossian, MD, PhD(Hon), Professor of Pathology, RushMedical College, Consulting Pathologist, Norwegian AmericanHospital, Chicago, Illinois

Debra Beneck, MD, Professor, Department of Pathology, WeillCornell Medicine, New York, New York

Melanie C. Bois, MD, Assistant Professor, Department ofLaboratory Medicine and Pathology, Fellow, Department ofLaboratory Medicine and Pathology, Mayo Clinic, Rochester,Minnesota

28

Alain Borczuk, MD, Professor of Pathology, Department ofPathology, NewYork-Presbyterian Hospital/Weill Cornell MedicalCenter, New York, New York

Darren Buonocore, MD, Assistant Attending, Department ofPathology, Memorial Sloan Kettering Cancer Center, New York,New York

Yasmeen M. Butt, MD, Assistant Professor, Department ofPathology, University of Texas Southwestern Medical Center,Dallas, Texas

Philip T. Cagle, MD, Professor, Department of Pathology andGenomic Medicine, Houston Methodist Hospital, Houston, Texas

Vera Capelozzi, MD, Associate Professor, Department ofPathology, University of São Paulo School of Medicine, São Paulo,Brazil

Ivan Chebib, MD, FRCPC, Assistant Professor, James HomerWright Pathology Laboratories, Harvard Medical School, AssistantPathologist, James Homer Wright Pathology Laboratories,Massachusetts General Hospital, Boston, Massachusetts

Sanja Dacic, MD, PhD, Professor of Pathology, Department ofPathology, University of Pittsburgh, Staff Pathologist, Departmentof Pathology, University of Pittsburgh Medical Center, Pittsburgh,Pennsylvania

John C. English, MD, FRCPC, Professor, Department ofPathology, Vancouver General Hospital, Vancouver, BritishColumbia, Canada

Armando E. Fraire, MD, Professor Emeritus, University ofMassachusetts Medical School, Worcester, Massachusetts

Allen R. Gibbs, MBBS, FRCPath, Consultant Histopathologist,Department of Cellular Pathology, University Hospital of Wales,Cardiff, Wales, United Kingdom

29

Krzysztof Glomski, MD, PhD, Resident, Department ofPathology, Massachusetts General Hospital, Boston, Massachusetts

Jason K. Graham, MD, First Deputy Chief Medical Examiner,The New York City Office of Chief Medical Examiner, New York,New York

Jeannette Guarner, MD, Professor, Department of Pathology andLaboratory Medicine, Emory University, Medical Director ofLaboratories, Laboratory Department, Emory University HospitalMidtown, Atlanta, Georgia

Ying-Han (Roger) Hsu, MD, FRCPC, Clinical Lecturer,Department of Laboratory Medicine and Pathology, University ofAlberta, Staff Pathologist, Department of Laboratory Medicine andPathology, Royal Alexandra Hospital, Edmonton, Alberta, Canada

Aliya N. Husain, MD, Professor, Department of Pathology,University of Chicago, Chicago, Illinois

Deepali Jain, MD, FIAC, Associate Professor, Department ofPathology, All India Institute of Medical Sciences, New Delhi,India

Keith M. Kerr, FRCPath, Professor, Department of Pathology,Aberdeen University Medical School, Consultant, Department ofPathology, Aberdeen Royal Infirmary, Aberdeen, Scotland, UnitedKingdom

Stacey A. Kim, MD, Assistant Professor, Department ofPathology and Laboratory Medicine, Cedars-Sinai Medical Center,Los Angeles, California

Brandon T. Larsen, MD, PhD, Assistant Professor, Departmentof Laboratory Medicine and Pathology, Mayo Clinic School ofMedicine, Senior Associate Consultant, Department of LaboratoryMedicine and Pathology, Mayo Clinic Arizona, Scottsdale, Arizona

Rodolfo Laucirica, MD, Vice Chair and Professor of Pathology,Department of Pathology and Laboratory Medicine, University of

30

Tennessee Health Science Center, Director of Anatomic Pathology,Methodist Hospital System, Memphis, Tennessee

Charles Leduc, MD, MSc, Assistant Professor, Department ofPathology and Cell Biology, University of Montreal, ThoracicPathologist, Department of Pathology, University of MontrealHealth Center, Montreal, Quebec, Canada

Yen-Wen Lu, MD, Chief Resident, Department of Pathology andLaboratory Medicine, Taipai Veterans General Hospital, Taipai,Taiwan

Maria Cecilia Mengoli, MD, Department of Surgical Pathology,Arcispedale Santa Maria Nuova-Azienda Sanitaria Locale-IRCCS,Reggio Emilia, Italy

Ross A. Miller, MD, Assistant Professor, Pathologist,Department of Pathology and Genomic Medicine, HoustonMethodist Hospital, Houston, Texas

Mari Mino-Kenudson, MD, Associate Professor, Department ofPathology, Harvard Medical School, Director, PulmonaryPathology Service, Department of Pathology, MassachusettsGeneral Hospital, Boston, Massachusetts

Paloma del C. Monroig-Bosque, MD, PhD, Physician ResidentPGY2, Department of Pathology and Genomic Medicine, HoustonMethodist Hospital, Houston, Texas

Cesar Moran, MD, Tenured Professor of Pathology, Departmentof Pathology, University of Texas MD Anderson Cancer Center,Houston, Texas

Bruno Murer, MD, Pathologist, Department of Pathology,Regional Hospital, Venezia, Italy

Raghavendra Pillappa, MD, Pulmonary Pathology Fellow,Department of Laboratory Medicine and Pathology, Mayo Clinic,Rochester, Minnesota

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Sergio Pina-Oviedo, MD, Assistant Professor, Department ofPathology, University of Arkansas for Medical Sciences, Little Rock,Arkansas

Jennifer Pogoriler, MD, PhD, Assistant Professor, Department ofPathology and Laboratory Medicine, Children’s Hospital ofPhiladelphia, Philadelphia, Pennsylvania

Theodore J. Pysher, MD, Professor (clinical), Department ofPathology, University of Utah School of Medicine, Salt Lake City,Utah

Kirtee Raparia, MD, Associate Pathologist, Department ofPathology, Kaiser Permanente Santa Clara Medical Center, SantaClara, California

Natasha Rekhtman, MD, PhD, Associate Attending Pathologist,Department of Pathology, Memorial Sloan Kettering Cancer Center,New York, New York

Robert W. Ricciotti, MD, Acting Assistant Professor, Departmentof Anatomic Pathology, University of Washington, AttendingPathologist, Department of Anatomic Pathology, University ofWashington Medical Center, Seattle, Washington

Anja C. Roden, MD, Associate Professor, Consultant,Department of Laboratory Medicine and Pathology, Mayo Clinic,Rochester, Minnesota

Philippe Romeo, MD, Assistant Professor, Department ofPathology, Université de Montréal, Attending Pathologist,Department of Pathology, Centre Hospitalier de l’Université deMontréal, Montreal, Quebec, Canada

Matthew W. Rosenbaum, MD, Resident, Department ofPathology, Massachusetts General Hospital, Boston, Massachusetts

Sinchita Roy-Chowdhuri, MD, PhD, Assistant Professor,Department of Pathology, University of Texas MD AndersonCancer Center, Houston, Texas

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Anjali Saqi, MD, MBA, Professor, Department of Pathology andCell Biology, Columbia University Medical Center, New York-Presbyterian, New York, New York

Lynette M. Sholl, MD, Associate Pathologist, Department ofPathology, Brigham and Women’s Faulkner Hospital, Boston,Massachusetts

Anna Sienko, MD, Full Clinical Professor, Department ofPathology, College of Medicine, University of Calgary, Pathologist,Calgary Lab Services, Department of Pathology, Peter LougheedCentre, Calgary, Alberta, Canada

Maxwell L. Smith, MD, Associate Professor, Department ofLaboratory Medicine and Pathology, Mayo Clinic School ofMedicine, Consultant, Department of Laboratory Medicine andPathology, Mayo Clinic Arizona, Scottsdale, Arizona

Paul A. VanderLaan, MD, PhD, Assistant Professor, Departmentof Pathology, Harvard Medical School, Director of Cytopathology,Director of Thoracic Pathology, Department of Pathology, BethIsrael Deaconess Medical Center, Boston, Massachusetts

Sara O. Vargas, MD, Associate Professor, Department ofPathology, Harvard Medical School, Staff Pathologist, Departmentof Pathology, Boston Children’s Hospital, Boston, Massachusetts

Paul Wawryko, MD, FRCPC, Assistant Professor, Department ofPathology, University of Manitoba, Max Rady College of Medicine,Pathologist, Department of Pathology, St. Boniface Hospital,Winnipeg, Manitoba, Canada

Hui-Min Yang, MD, Assistant Clinical Professor, Department ofPathology and Laboratory Medicine, University of BritishColumbia, Consultant Pathologist, Department of Pathology andLaboratory Medicine, Vancouver General Hospital, Vancouver,British Columbia, Canada

Yi-Chen Yeh, MD, Attending Pathologist, Department ofPathology and Laboratory Medicine, Taipai Veterans General

33

Hospital, Taipai, Taiwan

Fang Zhou, MD, Assistant Professor, Department of Pathology,New York University School of Medicine, New York UniversityLangone Health: Tisch Hospital, New York, New York

34

Preface to the ThirdEditionNew technologies at the time the first edition of Color Atlas and Textof Pulmonary Pathology was published allowed us to create a uniquetextbook of digital age conciseness with all figures printed in color.Subsequently, those technologies have become widespread, but thedistinctive virtues of the original work have not been duplicated. Inthe decade since the publication of the second edition of this book,diagnosis in pulmonary pathology has undergone a number ofmodifications. New entities have been described, older entitiesredefined, and several major classifications revised: An update ofthe 2002 American Thoracic Society/European Respiratory Society(ATS/ERS) classification of idiopathic interstitial pneumonias waspublished in 2013; the Fifth World Symposium on PulmonaryHypertension was held in Nice, France, in 2013; the fourth editionof the World Health Organization Classification of Tumours of the Lung,Pleura, Thymus and Heart was published in 2015. Since the secondedition, the introduction of testing for molecular targeted therapiesand other advances has forever altered the role of the pathologist inthe diagnosis and treatment of pulmonary diseases.

We elected to produce a third edition that is not merely anadjustment of the previous text based on new developments inpulmonary pathology, but one predominantly constructed by neweditors and largely written by new contributors. Even the title of thebook is modified to reflect this progress: Pulmonary Pathology: AnAtlas and Text, third edition. While it is a newly composed book, thegeneral format of a user-friendly atlas that is highly illustrated,divided into readily accessible individual entities, and offering brief

35

Title pageTable of ContentsCopyrightDedicationContributing AuthorsPreface to the Third EditionPreface to the First EditionAcknowledgmentsSection 1 Normal Cytology and Histology Sinchita Roy-ChowdhuriChapter 1 BronchusChapter 2 Bronchioles and Alveolar DuctsChapter 3 Blood Vessels and LymphaticsChapter 4 AlveoliChapter 5 PleuraChapter 6 Normal Cytology of the Lung and Pleura

Section 2 Artifacts and Age-Related Changes Sinchita Roy-ChowdhuriChapter 7 Procedural and Laboratory ArtifactsChapter 8 Reactive Changes, Nonspecific Findings, and Age-Related ChangesChapter 9 Noncellular Structures

Section 3 Malignant Neoplasms Mari Mino-Kenudson, Sergio Pina-Oviedo, Sanja Dacic, 
Timothy C. Allen, Ross A. Miller, Philip T. CagleChapter 10 AdenocarcinomaPart 1. Lepidic AdenocarcinomaPart 2. Acinar AdenocarcinomaPart 3. Papillary AdenocarcinomaPart 4. Micropapillary AdenocarcinomaPart 5. Solid AdenocarcinomaPart 6. Invasive Mucinous AdenocarcinomaPart 7. Colloid AdenocarcinomaPart 8. Fetal AdenocarcinomaPart 9. Enteric AdenocarcinomaPart 10. Signet Ring and Clear Cell Features

Chapter 11 Squamous-Cell CarcinomaPart 1. Keratinizing Squamous-Cell CarcinomaPart 2. Nonkeratinizing Squamous-Cell CarcinomaPart 3. Basaloid Squamous-Cell Carcinoma

Chapter 12 Adenosquamous CarcinomaChapter 13 Large-Cell CarcinomaChapter 14 Neuroendocrine CarcinomasPart 1. Small-Cell CarcinomaPart 2. Carcinoid TumorPart 3. Atypical Carcinoid TumorPart 4. Large-Cell Neuroendocrine Carcinoma

Chapter 15 Sarcomatoid CarcinomasPart 1. CarcinosarcomaPart 2. Pulmonary BlastomaPart 3. Pleomorphic Carcinoma

Chapter 16 Salivary Gland–Type CancersPart 1. Adenoid Cystic CarcinomaPart 2. Mucoepidermoid CarcinomaPart 3. Epithelial–Myoepithelial Carcinoma

Chapter 17 Lymphoepithelioma-Like CarcinomaChapter 18 NUT CarcinomaChapter 19 Primary Pulmonary SarcomasPart 1. Inflammatory Myofibroblastic TumorPart 2. Pleuropulmonary BlastomaPart 3. Epithelioid HemangioendotheliomaPart 4. Kaposi SarcomaPart 5. Synovial SarcomaPart 6. Malignant Solitary Fibrous TumorPart 7. Intimal SarcomaPart 8. SMARCA4-Deficient Thoracic SarcomaPart 9. Primary Pulmonary Myxoid Sarcoma with EWSR1-CREB1 Translocation

Chapter 20 Secondary Pulmonary SarcomasPart 1. LeiomyosarcomaPart 2. AngiosarcomaPart 3. OsteosarcomaPart 4. ChondrosarcomaPart 5. LiposarcomaPart 6. Malignant Peripheral Nerve Sheath TumorPart 7. RhabdomyosarcomaPart 8. Undifferentiated Soft Tissue SarcomaPart 9. Ewing Sarcoma

Chapter 21 Other Pulmonary SarcomasPart 1. Alveolar Soft Part SarcomaPart 2. Clear Cell SarcomaPart 3. Desmoplastic Small Round Cell TumorPart 4. Extrarenal Rhabdoid TumorPart 5. ChordomaPart 6. Extraskeletal Myxoid Chondrosarcoma

Chapter 22 Pulmonary B-Cell LymphomasPart 1. Primary and Secondary Lung InvolvementSubpart 1.1. Extranodal Marginal Zone Lymphoma (MZL) of the Mucosa-Associated Lymphoid Tissue (MALT Lymphoma)Subpart 1.2. Diffuse Large B-Cell Lymphoma (DLBCL)Subpart 1.3. Lymphomatoid Granulomatosis (LyG)Part 2. Systemic B-Cell Lymphomas with Secondary Lung InvolvementSubpart 2.1. Small B-Cell LymphomasSubpart 2.2. Other B-Cell Lymphomas

Chapter 23 Pulmonary Classical Hodgkin LymphomaChapter 24 Pulmonary T-Cell LymphomasPart 1. Peripheral T-cell Lymphoma, NOSPart 2. Systemic T-cell Lymphomas with Secondary Lung InvolvementSubpart 2.1. Pulmonary (Visceral) Involvement by Mycosis Fungoides/Sézary SyndromeSubpart 2.2. Pulmonary Anaplastic Large-Cell Lymphoma (ALCL)

Chapter 25 Pulmonary Plasma Cell Neoplasms and Related ConditionsPart 1. Primary Pulmonary Plasma Cell NeoplasmsPart 2. Systemic Plasma Cell Neoplasm with Secondary Lung Involvement

Chapter 26 Other Systemic Hematolymphoid Neoplasms with Secondary Lung InvolvementPart 1. Acute Leukemia or Myeloproliferative NeoplasmsSubpart 1.1. Acute LeukemiaSubpart 1.2. Myeloproliferative Neoplasms

Chapter 27 Other Neoplasms of the LungPart 1. Malignant MelanomaPart 2. Pleuropulmonary ThymomaPart 3. Malignant Germ Cell TumorsPart 4. LymphangioleiomyomatosisPart 5. Ciliated Muconodular Papillary Tumor of the Lung

Chapter 28 Metaplastic, Dysplastic, and Premalignant LesionsPart 1. Atypical Adenomatous HyperplasiaPart 2. Adenocarcinoma In SituPart 3. Minimally Invasive AdenocarcinomaPart 4. Squamous Metaplasia, Squamous Dysplasia, and Squamous Carcinoma In SituSubpart 4.1. Squamous MetaplasiaSubpart 4.2. Squamous DysplasiaSubpart 4.3. Squamous Carcinoma In SituPart 5. Squamous Papilloma and PapillomatosisSubpart 5.1. Glandular Papilloma and Mixed Squamous and Glandular PapillomaPart 6. Diffuse Idiopathic Pulmonary Neuroendocrine-Cell Hyperplasia (DIPNECH)

Chapter 29 Neoplasms of the PleuraPart 1. Diffuse Malignant MesotheliomaPart 2. Localized Malignant MesotheliomaPart 3. Well-Differentiated Papillary MesotheliomaPart 4. Synovial SarcomaPart 5. Vascular SarcomasPart 6. Malignant SFTPart 7. Pseudomesotheliomatous CarcinomaPart 8. Calcifying Fibrous TumorPart 9. Desmoplastic Small Round Cell Tumor

Section 4 Benign Neoplasms Natasha RekhtmanChapter 30 Pulmonary HamartomaChapter 31 Pulmonary ChondromaChapter 32 Solitary Fibrous TumorChapter 33 Desmoid-Type FibromatosisChapter 34 Carcinoid TumorletChapter 35 Pulmonary Meningothelial NoduleChapter 36 Sclerosing PneumocytomaChapter 37 Alveolar AdenomaChapter 38 Papillary AdenomaChapter 39 Mucous Gland AdenomaChapter 40 OncocytomaChapter 41 Pleomorphic AdenomaChapter 42 Multifocal Multinodular Pneumocyte HyperplasiaChapter 43 PEComaChapter 44 Glomus TumorChapter 45 Giant Cell TumorChapter 46 Meningioma

Section 5 Pulmonary Histiocytic Proliferations Anja C. RodenChapter 47 Pulmonary Langerhans-Cell HistiocytosisChapter 48 Erdheim–Chester DiseaseChapter 49 Rosai–Dorfman DiseaseChapter 50 Other Pulmonary Histiocytic Proliferations

Section 6 Benign and Borderline Lymphoid Proliferations Kirtee RapariaChapter 51 Follicular Bronchiolitis and Follicular BronchitisChapter 52 Nodular Lymphoid HyperplasiaChapter 53 Lymphoid Interstitial Pneumonia

Section 7 Focal Lesions Ross A. MillerChapter 54 Apical CapsChapter 55 Focal ScarsChapter 56 Pulmonary OssificationChapter 57 Intrapulmonary Lymph NodesChapter 58 Rounded AtelectasisChapter 59 Amyloidosis (Nodular and Tracheobronchial)

Section 8 Granulomatous Diseases Yasmeen M. ButtChapter 60 Infectious GranulomasPart 1. MycobacteriumPart 2. FungiPart 3. Parasites

Chapter 61 Bronchocentric GranulomatosisChapter 62 Pulmonary Hyalinizing GranulomaChapter 63 SarcoidosisChapter 64 BerylliosisChapter 65 Sarcoid-Like ReactionChapter 66 Necrotizing Sarcoid GranulomatosisChapter 67 Foreign-Body GranulomasPart 1. Intravenous Drug AbusePart 2. AspirationPart 3. Other Foreign-Body Reactions

Chapter 68 Nodules Resembling GranulomasPart 1. Rheumatoid NodulesPart 2. Malakoplakia

Section 9 Diffuse Pulmonary Hemorrhage Lynette M. ShollChapter 69 Alveolar Hemorrhage without VasculitisPart 1. Artifactual (Procedural) Hemorrhage/Hemorrhage in the Absence of Other Histologic AbnormalitiesPart 2. Hemorrhage as a Secondary Finding (Infection, Malignancy)Part 3. Hemorrhage with Diffuse Alveolar DamagePart 4. Passive CongestionPart 5. Arteriovenous MalformationsPart 6. Idiopathic Pulmonary Hemosiderosis

Chapter 70 Alveolar Hemorrhage with VasculitisPart 1. Vasculitis in Collagen Vascular DiseasesPart 2. Anti–Glomerular Basement Membrane Antibody Disease (Goodpasture Syndrome)Part 3. Granulomatosis with Polyangiitis (Formerly Wegener Granulomatosis)Part 4. Eosinophilic Granulomatosis with Polyangiitis (Formerly Churg–Strauss Syndrome)Part 5. Antiphospholipid SyndromePart 6. Microscopic Polyangiitis

Section 10 Pulmonary Hypertension and Embolic Disease Alain BorczukChapter 71 Pulmonary Arterial HypertensionChapter 72 Pulmonary Veno-Occlusive DiseaseChapter 73 Pulmonary Capillary HemangiomatosisChapter 74 Pulmonary Hypertension Associated with Lung Disease and/or HypoxemiaChapter 75 Thromboembolic Disease—Acute and ChronicPart 1. ThromboemboliPart 2. Foreign-Body EmboliPart 3. Fat EmboliPart 4. Amniotic Fluid EmbolismPart 5. Tumor EmboliPart 6. Parasitic EmboliPart 7. Bone Marrow Emboli

Chapter 76 Pulmonary InfarctChapter 77 Pulmonary Hypertension with Unclear or Multifactorial Mechanisms

Section 11 Large Airways Ross A. MillerChapter 78 BronchiectasisChapter 79 Middle Lobe SyndromeChapter 80 Tracheobronchopathia OsteochondroplasticaChapter 81 AsthmaChapter 82 Allergic Bronchopulmonary Aspergillosis

Section 12 Small Airways Sanja DacicChapter 83 Bronchiolar and Peribronchiolar Inflammation, Fibrosis, and MetaplasiaChapter 84 Lobular PneumoniaChapter 85 Organizing PneumoniaChapter 86 Constrictive BronchiolitisChapter 87 Respiratory Bronchiolitis and Membranous BronchiolitisChapter 88 Follicular BronchiolitisChapter 89 Diffuse PanbronchiolitisChapter 90 Small Airways and Inorganic Dust

Section 13 Alveolar Infiltrates Mary Beth BeasleyChapter 91 Acute PneumoniaChapter 92 Pulmonary EdemaChapter 93 Diffuse Alveolar DamageChapter 94 Acute Fibrinous and Organizing PneumoniaChapter 95 Lipoid PneumoniaChapter 96 Eosinophilic PneumoniaChapter 97 Desquamative Interstitial Pneumonia (DIP)-Like PatternChapter 98 Pulmonary Alveolar Proteinosis

Section 14 Tobacco-Related Diseases Lynette M. ShollChapter 99 EmphysemaPart 1. Placental Transmogrification of the Lung

Chapter 100 Chronic BronchitisChapter 101 Respiratory BronchiolitisChapter 102 Respiratory Bronchiolitis-Interstitial Lung Disease/Desquamative 
Interstitial PneumoniaPart 1. Pulmonary Langerhans Cell Histiocytosis

Chapter 103 Smoking-Related Interstitial Fibrosis

Section 15 Diffuse Interstitial Lung Diseases Maxwell L. SmithChapter 104 Hypersensitivity PneumonitisChapter 105 Hot Tub LungChapter 106 Flock LungChapter 107 Airway-Centered FibrosisChapter 108 Diffuse Alveolar Septal AmyloidosisChapter 109 Honeycomb LungChapter 110 Lung Disease in Inflammatory Bowel DiseaseChapter 111 Common Variable Immunodeficiency Disorders/
Granulomatous–Lymphocytic Interstitial Lung Disease (CVID/GLILD)–
Associated Lung DiseaseChapter 112 Chronic Aspiration BronchiolitisChapter 113 IgG4-Related Pulmonary DiseaseChapter 114 Diffuse Meningotheliomatosis

Section 16 Idiopathic Interstitial Pneumonias Kirtee RapariaChapter 115 Acute Interstitial PneumoniaChapter 116 Usual Interstitial PneumoniaChapter 117 Nonspecific Interstitial PneumoniaChapter 118 Cryptogenic Organizing PneumoniaChapter 119 Idiopathic Pleuroparenchymal Fibroelastosis

Section 17 Specific Infectious Agents Alain BorczukChapter 120 VirusesPart 1. CytomegalovirusPart 2. Herpes Simplex VirusPart 3. Varicella Zoster VirusPart 4. AdenovirusPart 5. InfluenzaPart 6. ParainfluenzaPart 7. MeaslesPart 8. Respiratory Syncytial VirusPart 9. Hantavirus

Chapter 121 BacteriaPart 1. StreptococcusPart 2. StaphylococcusPart 3. KlebsiellaPart 4. PseudomonasPart 5. LegionellaPart 6. ActinomycesPart 7. NocardiaPart 8. MycoplasmaPart 9. Coxiella burnetiPart 10. Rhodococcus

Chapter 122 MycobacteriaChapter 123 FungiPart 1. AspergillusPart 2. MucoralesPart 3. PneumocystisPart 4. HistoplasmaPart 5. CryptococcusPart 6. CoccidioidesPart 7. ParacoccidioidesPart 8. BlastomycosisPart 9. CandidaPart 10. Phaeohyphomycosis

Chapter 124 ParasitesPart 1. StrongyloidesPart 2. DirofilariaPart 3. ToxoplasmaPart 4. AcanthamoebaPart 5. ParagonimusPart 6. SchistosomaPart 7. LeishmaniaPart 8. Echinococcus

Section 18 Transplant-Related Pathology Aliya N. HusainChapter 125 Acute Lung Transplant RejectionChapter 126 Chronic Lung Allograft DysfunctionChapter 127 Antibody-Mediated Lung Transplant RejectionChapter 128 Anastomotic ComplicationsChapter 129 Transplant-Related InfectionsChapter 130 Primary Graft DysfunctionChapter 131 Organizing Pneumonia in the Transplanted LungChapter 132 Other Lung Transplant–Related PathologyChapter 133 Posttransplant Lymphoproliferative DisordersChapter 134 Lung Pathology in Transplantation of Other Organs

Section 19 Lung Pathology in Collagen Vascular Diseases Lynette M. ShollChapter 135 Lung Pathology in Collagen Vascular Diseases

Section 20 Therapeutic Drug Reactions and Radiation Effects Brandon T. LarsenChapter 136 AmiodaroneChapter 137 MethotrexateChapter 138 NitrofurantoinChapter 139 Fenfluramine–Phentermine (“Fen–Phen”)Chapter 140 Targeted Molecular TherapiesChapter 141 Other DrugsChapter 142 Radiation Pneumonitis

Section 21 Pneumoconioses Timothy C. AllenChapter 143 AsbestosisChapter 144 SilicosisChapter 145 SilicatosisChapter 146 Mixed Pneumoconiosis and Mixed-Dust PneumoconiosisChapter 147 Coal Worker’s PneumoconiosisChapter 148 Giant-Cell Interstitial Pneumonia/Hard-Metal PneumoconiosisChapter 149 SiderosisChapter 150 Aluminosis

Section 22 Metabolic Disorders/Storage Diseases Timothy C. AllenChapter 151 Pulmonary Alveolar MicrolithiasisChapter 152 Pulmonary Metastatic Calcification/CalcinosisChapter 153 Storage Diseases

Section 23 Nonneoplastic Lesions of the Pleura Ross A. MillerChapter 154 Fibrinous and Fibrous PleuritisChapter 155 Specific Forms of PleuritisChapter 156 Eosinophilic PseudovasculitisChapter 157 Reactive Mesothelial HyperplasiaChapter 158 EndometriosisChapter 159 SplenosisChapter 160 Ectopic Hepatic TissueChapter 161 Nodular Histiocytic Hyperplasia

Section 24 Pediatric Pulmonary Pathology Aliya N. HusainChapter 162 Congenital Pulmonary Airway Malformation Type 1Chapter 163 Developmental Abnormalities Associated with Bronchial ObstructionChapter 164 Congenital Pulmonary Airway Malformation Type 3Chapter 165 Pulmonary SequestrationChapter 166 Bronchogenic CystChapter 167 Pulmonary Growth AbnormalitiesChapter 168 Neuroendocrine Hyperplasia of InfancyChapter 169 Pulmonary Interstitial GlycogenosisChapter 170 Genetic Disorders of Surfactant MetabolismChapter 171 Cystic FibrosisChapter 172 Primary Ciliary DyskinesiaChapter 173 Chronic Granulomatous DiseaseChapter 174 Alveolar Capillary Dysplasia with Misalignment of Pulmonary VeinsChapter 175 Acinar DysplasiaChapter 176 Complications of PrematurityChapter 177 Meconium AspirationChapter 178 Lymphatic DisordersChapter 179 Juvenile Respiratory PapillomatosisChapter 180 Pleuropulmonary BlastomaChapter 181 Other Primary Lung Tumors in ChildrenChapter 182 Pediatric Tumors Metastatic to the Lung

BibliographyIndex