vision · pure encapsulations is committed to producing the most complete line of science-based...

*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

VisionA Targeted Guide for Ocular Health*

• Antioxidant Protection*

• Macular Function*

• Healthy Tear Production*

• Eye Comfort*

• Vascular Integrity and Blood Flow*

PureOptics

Pure Encapsulations is committed to producing the most complete line of science-based nutritional supplements. Available exclusively through qualified health professionals, every finished product is pure and hypo-allergenic to best optimize the long-term health of the most sensitive patients.

Pure Encapsulations products contain only the highest quality, hypo-allergenic ingredients in their most bioavailable forms. Products never contain hidden fillers, coatings, artificial colors or other excipients and are always free of wheat, gluten, preservatives and hydrogenated oils. Label claims and potency are verified by 3rd-party laboratories. Independent heavy metal, pesticide and microbiological testing is also performed to ensure supplement purity and safety.

Pure Encapsulations was inspected by the FDA in August of 2009 and met, and in many cases, exceeded, all GMP requirements. In addition, Pure Encapsulations has elected to be audited annually by NSF International and is NSF-GMP registered in the U.S., GMP certified in Canada and exceeds the standards of the United States Pharmacopeia (USP) for supplement manufacturing.

Pure Encapsulations products are formulated by nutritionists, Ph.D.s and medical experts to provide strengths and dosing consistent with clinical experience and double-blind, placebo-controlled studies, the gold standard of research design.

PureOptics

2 TO ORDER CALL 800-753-2277 Secure online ordering and information at www.PureEncapsulations.com

Vision HealthEstimates suggest 8 million people over the age of 55 are concerned with eye health and this number is only expected to increase. Research indicates that specific nutrients could offer targeted support for vision and eye health.1

Retina and Macular SupportA long-term, multicenter, prospective study involving more than 5,000 individuals ages 55-80 has revealed that high amounts of vitamin C, vitamin E, zinc and copper support the health of the macula.2 Higher serum vitamin D levels and omega-3 fatty acids have also been associated with positive support in other trials.3,4 Another large, multi-center, clinical trial is currently underway examining macular support from fish oil, lutein and zeaxanthin.*

Healthy Tear ProductionOmega-3 essential fatty acids have also been associated with eye hydration and comfort. In a 10-year, randomized, double-blind, placebo-controlled study involving nearly 40,000 women, higher intake of omega-3 fatty acids was associated with retention of eye moisture.5 Research suggests that these essential fatty acids, including EPA, DHA and GLA, support the composition of the lipid, aqueous and mucin layers that comprise the tear film, the coating of fluid that covers the eye. They also support healthy prostaglandin and cytokine production to promote inflammatory balance and eye comfort.6*

Sclera

OpticNerve

Lens

Pupil

Iris

Cornea

Retina

Macula

Healthy vision depends on the complex dynamics of several important parts of the eye working together. In this process light rays reflect off of an object and enter the eye through the cornea. The lens is suspended behind the iris and helps focus light onto the retina. At the back of the eye the light is focused by the retina. The macula is the central area of the retina responsible for sharp vision. The light is then converted into signals sent to the brain along the optic nerve.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. 3

VisionPro Nutrientsthree vegetable capsules contain v 00

AmOunT pER sERvingvitamin A (acetate) ............................................................................5,000 i.u.vitamin C (as ascorbic acid) ............................................................... 500 mgvitamin C (as ascorbyl palmitate) .......................................................... 8 mgvitamin D3 .............................................................................................1,000 i.u.vitamin E (as d-alpha tocopherol succinate) ...................................400 i.u.thiamine HCl (B1) ...................................................................................... 5 mgriboflavin (B2) ......................................................................................... 2.5 mgriboflavin 5’phosphate (activated B2) ................................................. 2.5 mgniacinamide ............................................................................................ 20 mgpyridoxine HCl (B6) ................................................................................... 5 mgpyridoxal 5’ phosphate (activated B6) ................................................... 5 mgfolate (as Metafolin®, L-5-MTHF) ................................................... 400 mcgmethylcobalamin (B12) ....................................................................... 200 mcgbiotin ..................................................................................................... 300 mcgpantothenic acid (calcium pantothenate) (B5) ................................. 25 mgiodine (potassium iodide) .................................................................. 150 mcgzinc (citrate) ............................................................................................ 25 mgselenium (selenomethionine) ............................................................. 75 mcgcopper (glycinate) .................................................................................... 2 mgmanganese (citrate) ............................................................................. 2.5 mgchromium (polynicotinate) ................................................................ 120 mcgmolybdenum .......................................................................................... 75 mcg

(as TRAACS® molybdenum glycinate chelate)boron (glycinate) ...................................................................................... 1 mgvanadium (as bis-glycinato oxo vanadium) ..................................... 50 mcgEyeprotect Complex

alpha lipoic acid ................................................................................... 50 mgtaurine.................................................................................................... 50 mgresVida® resveratrol (as trans-resveratrol) .................................... 25 mg

macularsynergy Extralutein ...................................................................................................... 10 mgzeaxanthin ............................................................................................... 2 mglycopene .................................................................................................. 1 mg

(hypo-allergenic plant fiber added to complete capsule volume requirement)

3 capsules per day, with meals. quantity order codeVisionPro Nutrients 90 VPN9

✓ Comprehensive three-capsule per day multivitamin/mineral complex for maintaining healthy vision*

✓ Antioxidants: Clinically researched levels of vitamin C, vitamin E, zinc and copper in highly bioavailable forms to support healthy vision and eye integrity*

✓ macularsynergy Extra: 10 mg lutein, 2 mg zeaxanthin and 1 mg lycopene per serving help maintain macular and retinal health*

✓ Eyeprotect Complex: Alpha lipoic acid, taurine and resveratrol support visual function and healthy photoreceptor activity*

This product contains resVida®. resVida® is a registered trademark of DSM Nutritional Products, Inc.lutein is a registered trademark of Kemin Industries, Inc.

Zeaxanthin is sourced from OPTISHARP™ brand. OPTISHARP™ is a trademark of DSM Nutritional Products, Inc. Metafolin® is a registered trademark of Merck KGaA, Darmstadt, Germany. TRAACS is a registered trademark of Albion Laboratories, Inc.

promotes healthy aging


✓ Supports natural tear production and eye comfort with ultra-pure, molecularly distilled triglyceride fish oil and borage oil combination*

✓ Maintains healthy tear film composition and moisture retention in the eye*

✓ Promotes healthy prostaglandin and cytokine balance to protect ocular function*

VisionPro EPA/DHA/GLAthree softgel capsules contain (20 sg)

AmOunT pER sERvingcalories ...........................................................................................................30

calories from fat ...................................................................................................................30total fat ...........................................................................................................3 gfish oil concentrate (anchovies, sardines) ................................... 2,871 mg

providing:EPA (eicosapentaenoic acid)............................................................855 mgDHA (docosahexaenoic acid) ...........................................................645 mgother omega-3 fatty acids .................................................................195 mg

borage oil (seed) .................................................................................. 450 mgproviding:

gamma-linolenic acid (GLA) ................................................................75 mgother ingredients: natural lemon-lime flavor, proprietary natural antioxidant blend, gelatin capsule

3 softgel capsules per day, with a meal. quantity order codeVisionPro EPA/DHA/GLA 180 VPE1

90 VPE9


✓ Provides key antioxidants to support healthy vision and the integrity of the eye*

✓Maintains the health of the retina and macula, as indicated in a large, randomized, double-blind, placebo-controlled clinical trial*

✓Offers clinically researched levels of vitamin C, vitamin E, zinc and copper in optimally bioavailable forms*

EyeProtect Basicstwo vegetable capsules contain v 00

AmOunT pER sERvingvitamin C (as ascorbic acid) ............................................................... 500 mgvitamin C (as ascorbyl palmitate) .......................................................... 8 mgvitamin E (as d-alpha tocopherol succinate) ...................................400 i.u.zinc (citrate) ............................................................................................ 25 mgcopper (glycinate) .................................................................................... 2 mg(hypo-allergenic plant fiber added to complete capsule volume requirement)

2 capsules per day, with meals. quantity order codeEyeProtect Basics 60 EPB6


✓ Offers comprehensive macular protection with key antioxidants*

✓ Moderates visual fatigue and enhances light to dark adjustments with bilberry*

✓ Promotes macular pigment integrity and density to support retinal and optic lens health*

Macular Support Formulatwo vegetable capsules contain v 0 AmOunT pER sERvingn-acetyl-l-cysteine (free-form) .......................................................... 250 mgl-glutathione (reduced) (free-form) ..................................................... 50 mgbilberry (Vaccinium myrtillus) extract ................................................ 80 mg

(standardized to contain 25% anthocyanosides)grape (Vitis vinifera) seed extract ....................................................... 50 mg

(standardized to 92% polyphenols)lutein ........................................................................................................... 6 mgzeaxanthin ................................................................................................. 1 mgmixed carotenoids ...........................................................................25,000 i.u.

providing:beta carotene .................................................................................................. 15,000 mcglycopene ................................................................................................................ 425 mcglutein....................................................................................................................... 850 mcgzeaxanthin ............................................................................................................. 170 mcg

vitamin C (as ascorbic acid) ............................................................... 800 mgvitamin C (as ascorbyl palmitate) ........................................................ 42 mg

2-4 capsules per day, in divided doses, with meals. quantity order codeMacular Support Formula 120 MS1

60 MS6

lutein is a registered trademark of Kemin Industries, Inc. Zeaxanthin is sourced from OPTISHARP™ brand. OPTISHARP™ is a trademark of DSM Nutritional Products, Inc.

is a registered trademark of KYOWA HAKKO BIO Co.,Ltd


✓ Provides targeted eye support as the main carotenoid stored in the retina*

✓ Promotes the integrity and density of the macular pigment*

✓ Supports healthy vision through pigment associated antioxidant protection and light screening mechanisms*

lutein is a registered trademark of Kemin Industries, Inc.

Lutein 20 mgeach softgel capsule contains (6 sg) AmOunT pER sERvinglutein ......................................................................................................... 20 mgvitamin E (mixed tocopherols).................................................................1 i.u.other ingredients: safflower oil, beeswax, gelatin capsule

1-2 capsules per day, with meals. quantity order codeLutein 20 mg 120 LU1

60 LU6


✓ Provides both major carotenoids stored in the eye for dual-strength support of the retina and optical lens*

✓ Promotes the integrity and density of the macular pigment*

✓ Targets multiple areas in the retina to enhance total retinal health*

✓ Supports light filtering in the eye to maintain healthy photoreceptor function and color vision*

Lutein is a carotenoid found naturally in dark green leafy vegetables, such as kale, spinach and broccoli. It is typically found in combination with its stereoisomer zeaxanthin.

Lutein and zeaxanthin are the two major carotenoid pigments in the human macula and retina. These carotenoids act in the eye as macular pigments, helping to promote the integrity and density of the macula lutea. Multiple clinical studies suggest a direct relationship between lutein supplementation and macula lutein concentration.7,8*

Studies have found that lutein and zeaxanthin support the eyes in numerous ways: • Provideantioxidantdefensestoprotectoculartissuefromoxidativestress*• Promotegapjunctioncommunications,resultinginimprovedsignalefficiencyin

the retina*• Filterthehigh-energybluewavelengthsoflight,preservingvisualfunctioninpart

by minimizing retinal glare 9*

Higher intakes of these carotenoids have been associated with greater macular and lens support potential and color vision. 10,11 Clinical trials involving lutein supplementation have suggested enhanced visual acuity in subjects.9,12Ina12-month,randomized,double-blind,placebo-controlledtrialinvolving90subjects10mgofluteinpromoted visual function both alone and when combined with a multivitamin.13*

Lutein/Zeaxanthin

lutein is a registered trademark of Kemin Industries, Inc. Zeaxanthin is sourced from OPTISHARP™ brand. OPTISHARP™ is a trademark of DSM Nutritional Products, Inc.

LuTEin COnTEnT Of COmmOn fOODs

Kale 1 cup cooked

51 mg

Collard greens 1 cup cooked

15 mg

spinach 1 cup cooked

9 mg

Broccoli 1 cup cooked

3.4 mg

peas 1 cup cooked

2.1 mg

Romaine lettuce 1 cup raw

1.4 mg

each vegetable capsule contains v 0

AmOunT pER sERvinglutein ......................................................................................................... 10 mgzeaxanthin ................................................................................................. 2 mgother ingredients: red beet powder(hypo-allergenic plant fiber added to complete capsule volume requirement)

1 capsule per day, with a meal. quantity order codeLutein/Zeaxanthin 120 LZ1

60 LZ6


✓ Promotes vascular integrity and microvascular blood flow to the eye with anthocyanidins*

✓ Moderates visual fatigue and supports light to dark adjustments*

✓ Provides antioxidants and supports endogenous antioxidant defenses to support retinal health*

Bilberry 160 mgeach vegetable capsule contains v 2

AmOunT pER sERvingbilberry (Vaccinium myrtillus) extract .............................................. 160 mg

(standardized to contain 25% anthocyanosides)vitamin C (as ascorbyl palmitate) .......................................................... 2 mg(hypo-allergenic plant fiber added to complete capsule volume requirement)

1-4 capsules per day, in divided doses, between meals. quantity order codeBilberry 160 mg 120 BB11

Bilberry 80 mgeach vegetable capsule contains v 3

AmOunT pER sERvingbilberry (Vaccinium myrtillus) extract ................................................ 80 mg

(standardized to contain 25% anthocyanosides)vitamin C (as ascorbyl palmitate) .......................................................... 1 mg(hypo-allergenic plant fiber added to complete capsule volume requirement)

3-8 capsules per day, in divided doses, between meals. quantity order codeBilberry 80 mg 120 BB81

60 BB86


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Pure Encapsulations, Inc., 490 Boston Post Road, Sudbury, Massachusetts 01776 USA [email protected] | www.PureEncapsulations.com | T: 800-753-2277 | F: 888-783-2277

490 Boston Post RoadSudbury, MA 01776 USA

‘

References

1. Bressler NM, Bressler SB, Congdon NG, et al. Potential public health impact of Age-Related Eye Disease Study results: AREDS report no. 11. Arch Ophthalmol. 2003 Nov;121(11):1621-4.

2. Age-Related Eye Disease Study Research Group. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8. Arch Ophthalmol. 2001 Oct;119(10):1417-36.

3. Parekh N, Chappell RJ, Millen AE, Albert DM, Mares JA. Association between vitamin D and age-related macular degeneration in the Third National Health and Nutrition Examination Survey, 1988 through 1994. Arch Ophthalmol. 2007 May;125(5):661-9.

4. SanGiovanni JP, Chew EY, Agrón E, et al. The relationship of dietary omega-3 long-chain polyunsaturated fatty acid intake with incident age-related macular degeneration: AREDS report no. 23. Arch Ophthal-mol. 2008 Sep;126(9):1274-9.

5. Miljanovic B, Trivedi KA, Dana MR, et al. Relation between dietary n-3 and n-6 fatty acids and clinically diagnosed dry eye syndrome in women. Am J Clin Nutr. 2005 Oct;82(4):887-93.

6. Rosenberg ES, Asbell PA. Essential fatty acids in the treatment of dry eye. Ocul Surf. 2010 Jan;8(1):18-28.

7. Bone RA, Landrum JT, Guerra LH, Ruiz CA. Lutein and zeaxanthin dietary supplements raise macular pigment density and serum concen-trations of these carotenoids in humans. J Nutr. 2003 Apr;133(4):992-8.

8. Mares JA, LaRowe TL, Snodderly DM, et al. Predictors of optical density of lutein and zeaxanthin in retinas of older women in the Carotenoids in Age-Related Eye Disease Study, an ancillary study of the Women’s Health Initiative. Am J Clin Nutr. 2006 Nov;84(5):1107-22.

9. Rodriguez-Carmona M, Kvansakul J, et al. The effects of supplementa-tion with lutein and/or zeaxanthin on human macular pigment density and colour vision. Ophthalmic Physiol Opt. 2006 Mar;26(2):137-47.

10. Age-Related Eye Disease Study Research Group, et al. The relationship of dietary carotenoid and vitamin A, E, and C intake with age-related macular degeneration in a case-control study: AREDS Report No. 22. Arch Ophthalmol. 2007 Sep;125(9):1225-32.

11. Delcourt C, Carrière I, Delage M, et al. Plasma lutein and zeaxanthin and other carotenoids as modifiable risk factors for age-related maculopathy and cataract: the POLA Study. Invest Ophthalmol Vis Sci. 2006 Jun;47(6):2329-35.

12. Stringham JM, Hammond BR. Macular pigment and visual perfor-mance under glare conditions. Optom Vis Sci. 2008 Feb;85(2):82-8.

13. Richer S, Stiles W, Statkute L, et al. Double-masked, placebo-controlled, randomized trial of lutein and antioxidant supplementation in the intervention of atrophic age-related macular degeneration: the Veterans LAST study (Lutein Antioxidant Supplementation Trial). Optometry. 2004 Apr;75(4):216-30.

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