TEOSYAL® PURESENSE REDENSITY 1 contains sterile hyaluronic acid and lidocaine. This medical device (CE 0086, class III) is indicated for the prevention of wrinkles, rehydratation of the face, neck and neckline.Contraindications: it is the practionner’s full responsability to read and follow those instructions for use in order to avoid any adverse reactions or complaints. Refer to instructions for use. TEOSYAL REDENSITY ® 1 is a trademark of the firm TEOXANE SA and it is a product of the TEOSYAL®PURESENSE range.

A MIX OF HIGHLY CONCENTRATED HYALURONIC ACID AND ESSENTIAL NUTRIENTS

* Essential amino acids cannot be made by the body. As a result, isoleucine, leucine, lysine, threonine and valine must come from food or other supplements.HA: Hyaluronic Acid AA: Amino acids1. Mendoza G, et al. Antioxidant profile of hyaluronan: physico-chemical features and its role in pathologies. Mini Rev Med Chem. 2009 Nov 1;9(13):1479-88.2. Anderegg U, et al. More than just a filler - the role of hyaluronan for skin homeostasis. Exp Dermatol. 2014 May;23(5):295-303.3. De Bandt JP, Cynober L. Therapeutic use of branched-chain amino acids in burn, trauma, and sepsis. J Nutr. 2006;136(1 Suppl):308S-13S.4. Gerard-Monnier D, Chaudiere J, Metabolism and antioxidant function of glutathion, Path. Biol.1996. 44, 77-85.5. Baspeyras M, et al. Clinical and biometrological efficacy of a hyaluronic acid-based mesotherapy product: a randomised controlled study. Arch Dermatol Res. 2013 Oct;305(8):673-82.

HYDRATION1 HA

ARGININE

TISSUE RESTRUCTURING AND CELL REGENERATION2,3

HA LEUCINE*

ISOLEUCINE*VALINE*GLYCINELYSINE*

THREONINE*PROLINE

VITAMIN B6 ZINC

COPPER

ANTIOXIDANT PROTECTION 1,4HA

GLUTATHIONE N-ACETYL-L-CYSTEIN

ALPHA-LIPOIC ACID

WITH LIDOCAINE

SKIN REDENSIFICATION

AND PREVENTION OF

THE SIGNS OF AGEING

REDENSITY1BEAUTY BOOSTER

REDENSITY 1 EXCLUSIVE PATENTED FORMULAFOR COMPLEMENTARY EFFECTS ON

SKIN CELL REGENERATION AND HEALTH 2,3

A STEP UP IN BEAUTY BOOSTING*There are potential side effects related to the implantation of this device, occurring immediately following injection or after a delay. The practitioner must inform the patient of this. Please consult the IFU for details.

Natural, highly concentrated non crosslinked HA (15 mg/ml) to improve hydration, firmness and

viscoelastic properties of the skin5

Unique patented formula of effective natural components:

8 AA (5 essentials among them leucine,essential for the cell regeneration process3)

3 antioxidants (including glutathione), recognized for their ability to protect against free radicals4

2 minerals, required for the cells’ health and protection

Vitamin B6, involved in cell metabolism

0.3% lidocaine to contribute to thepatient comfort during the injection

«Redensity1 is one of my favoriteproducts in my daily practice.

Hyaluronic acid found in Redensity1 makes the skin hydrated and

densified, and its association with nutrients makes the skin radiant and healthy.Redensity1unique properties make it safe*

to use even in thin and fragile skin.And my patients just love it so much!»

Dr. Aji Bayu Chandra, Indonesia

MICROINJECTIONSIN SUPERFICIAL TO MID DERMIS

Evaluation of TEOSYAL® PureSense Redensity 1 efficacy on skin regeneration and protection: study carried out by an independent laboratory, measuring the effect of a bolus of product injected into the upper reticular dermis of a skin explant. This skin model displays the beneficial effects of TEOSYAL® PureSenseRedensity 1 on skinbiomarkers6

A B

OO

STER

OF

D

ERM

O-R

ESTR

UC

TUR

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SKIN CELL REGENERATION & OXIDATIVE STRESS PROTECTION6,7

Der

mis

TENSOR EFFECT

+ 26% of fibrillin 1Control - Day 9 Redensity 1 - Day 9

Epid

erm

al-d

erm

alju

nctio

n

STRENGTHENING OF THE DERMOEPIDERMAL JUNCTION

+ 98% collagen IVControl - Day 9 Redensity 1 - Day 9

Ep

ider

mis

HYDRATION

X 14 of GAGsControl - Day 9 Redensity 1 - Day 9

GAGs: Glycosaminoglycans6. TEOSYAL® PureSense Redensity 1 study 10E2047 on human skin explants, conducted by BIO-ECfor TEOXANE, 2010.7. TEOSYAL® PureSense Redensity 1 complementary analysis to study 10E2047.

-28% of malondialdehyde(photo-induced oxidation marker)

ANTIOXIDANT ACTION

Pap

illar

y d

erm

is

STRONG PAPILLARY DERMIS DENSIFICATION

«The cosmetic world has been revolutionizedwith Redensity1, this hyaluronic acid

potentiated with bioregenerators rejuvenatesand replenishes the skin´s nutrients

lost with age.»Dr. Alejandro Rada Cassab, Colombia

Control - Day 9 Redensity 1 - Day 9

REDENSITY 1

FO

R A

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IBLE

B

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ST O

F TH

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KIN

PROVEN EFFICACY DEMONSTRATED IN A RANDOMIZED, DOUBLE-BLINDED TRIAL VERSUS PLACEBO

«This clinical study showed a significant effect of TEOSYAL® PureSense Redensity 1 injections on skin texture, roughness and volume of lines on the cheeks, in comparison with physiological saline solution injections.»

Skin hydration was also maintained at 8 weeks in the deep dermis on the side treated and significantly reduced on the placebo side.

RESULTS VALIDATED IN AN INTERNATIONAL TRIAL

8. Study report TEOSYAL® PureSense Redensity 1 versus placebo. Pr Humbert. Dec 2014.9. Study report TEOSYAL® PureSense Redensity 1. Dr Knoll, Dr Vivier, Dr Carre, Dr Micheels. May 2013.*There are potential side effects related to the implementation of this device, occurring immediately following injection or after a delay. The practitioner must inform the patient of this. Please consult the IFU for details.

«I always obtain very positive results with an innovative product which enables

to redensify the skin and to restore itsbrightness: Redensity1.»Prof. Giuseppe Sito, ItalyELASTICITY HYDRATION TEXTURE RADIANCE

0

5

15

10

20

25

30

35

40

45

50

NECKFACE NECKLINE

SCIENTIFICALLY PROVEN, VISIBLE & LASTING RESULTS

Design: First interventional, monocenter, randomised, double-blinded, comparative study (Redensity 1 injection versus phy-siological saline solution injection)Population: n=25 patientsPrimary endpoint: evaluation of the effect of Redensity 1 injections on skin relief (roughness), in the cheek area.Protocol: 3 injections at 3-week intervals on half-face and half-neck of Redensity 1 versus physiological saline solution (NaCl). Evaluations performed at T0 (before the first injections), T8 weeks and T18 weeks timepoints.

Pr P. Humbert, France, Dec 2014 8

Design: Multicenter clinical study (3 centers)Population: n= 40 patients, 72 indications (face: n=21/ neck: n=20 /neckline: n=31)Primary endpoints: evaluation of:- protocol efficacy regardless of

the injection technique (manual multi-bolus or spray gun).

- product efficacy for the face, neck and neckline areas.

- effects sustainability along the different evaluation visits.

- safety / adverse events, immediately after injections and 3 weeks after the last injection.

Protocol: 3 injections at 3-week intervals. Evaluations performed 9 weeks after the start of the protocol.

Dr J. Carré, Dr J. Vivier, France; Dr B. Knoll, Germany; Dr P. Micheels, Switzerland,May 20139

SUPERIOR IMPROVEMENT OF SKIN ROUGHNESS (PRIMARY ENDPOINT)WITH REDENSITY 18

IMPROVEMENT OF SKIN QUALITY9

Evolution of skin relief analysed by fringe projection versus baseline

Weeks T030

35

45

40

50

55

60

T8 T18

Redensity 1Physiological saline solution

3 INJECTIONS3 WEEKS APART

µm

p=0.0011*

p=0.0409*

The treatment was very well tolerated for these three indications.*

% IM

PRO

VEM

ENT

In terms of aesthetic perception: face, neck and neckline showed an aesthetic improvement between 53% and 61%

skin quality was improved by 35%

Evaluation performed 9 weeks after the 1st injection

* Statistical analysis compared results obtained at T8 and T18 vs baseline

REDENSITY 1

Skin Glow and Hydration

Timeweek 0 week 3 week 6 month 6

Intensive skin nourishment and hydration Maintenance of skin health, glow and density

1 session every 4 to 6 months3 sessions at 3-week intervals

SKIN

QU

ALI

TY U

PGRA

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ON

TH

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NG

RU

N

SEVERAL WAYS TO USE REDENSITY 1For the face, neck and neckline

• Regularly as core treatment to prevent cutaneous ageing

• In alternation with or as a complement to other treatments

• On specific chosen occasions to rehydrate and give a new glow to the skin (for example, before/after prolonged sun exposure...)

NEW PATIENTSA minimally invasive option to help them to take the first step

PATIENTS USED TO FILLER INJECTIONSIn alternation to other treatments, to maintain their results and/or as a complement to magnify the effect of a filler injection

• For an optimum treatment: 3 sessions at 3-week intervals for immediate and cumulative results

• For a maintenance treatment of the results, as soon as the need is felt: 1 session usually 3 times a year

• 2 packaging sizes available - 2 x 1 ml syringe for targeted treatments - 1 x 3 ml syringe for global aesthetic treatments

IMMEDIATE & LONG-LASTING RESULTSFOR ALL YOUR PATIENTS

«Redensity1: a natural, preventive, moisturizing and replenishing care, as well

as an excellent maintenance treatmentof hyaluronic acid injections.»Dr. Sandrine Sebban, France

A COMPLETE PROTOCOL FOR LONG-LASTING RESULTS

RADIANCE

TONICITYELASTICITYHYDRATION

REDENSITY 1

84,7% THINK THE PROTOCOL

IS SUITABLE9

FO

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EP

B

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F C

ON

FID

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9. Study report TEOSYAL® PureSense Redensity 1. Dr Knoll, Dr Vivier, Dr Carre, Dr Micheels. May 2013.

A HIGH PATIENT SATISFACTION

91,7% ARE READY TO REPEAT

THE TREATMENT9

90,3%WOULD

RECOMMENDTHE TREATMENT9

OF PATIENTS WERESATISFIED WITH

THEIR TREATMENT9

91,7%

«This product can be used for all types and stages of ageing and provides excellent

clinical results.»Dr. Vladlena Averina, Ukraine

BRIGHTEN

PROTECTSMOOTH

REPLENISH

«As soon as Redensity1 appeared in Russia it became my favourite in the complex of anti-age treatment. Redensity1 biorevitalisation is the base that allows you to prepare the skin for more invasive manipulations and plastic surgery. The unique composition of R1

produces excellent aesthetic results without any risk of side effects and allergic reactions. It is tested by time and practice.»

Dr. Yuliya Brovkina, Russia

BEFORE

AFTER

Unstructured network (uni-directional)

Remodelled, tightened network (multi-directional)

VISIBLE AND MEASURED EFFICACY9

REDENSITY 1

In today’s world, beauty is no longer

a question of age. Women want their

beauty to last into the future.

That’s why TEOXANE Laborator ies

s p e c i a l i s e i n t h e c o m p l e x

deve lopment o f hya lu ron ic ac id

in jecta b le ge l s w i th researcher s

dr iven by the culture of excellence

and innovat ion as wel l as a total

dedication to effectiveness and safety.

Thanks to this approach, the hyaluronic

acid gels we produce in our Geneva-

based laboratories are of the highest

quality and purity.

Mrs Valérie Taupin

CEO & Founder, TEOXANE

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TEOXANE Geneva Les Charmilles - Rue de Lyon, 105

CH 1203 Geneva www.teoxane.com