putting yeast to work: reducing supply chain volatility

9/12/2016 September 2016Supply Chain Insights Global Summit #Imagine2030

Howard FullerAmyris

Vice President, Quality and Supply Chain


Putting Yeast to Work: Reducing Supply Chain

Volatility

Howard FullerAmyris

Vice President, Quality and Supply Chain

9/12/2016 September 2016Supply Chain Insights Global Summit #Imagine2030 September 2016Supply Chain Insights Global Summit #Imagine2030

Agenda

Introduction

The Supply Chain Challenge

The Supply Chain Opportunity

Examples of Success

Conclusion

Q&ACopyright © Amyris, Inc. All rights reserved


Introduction

Copyright © Amyris, Inc. All rights reserved


What Inspires Us?Industrial biotechnology delivering better materials that make sourcing sustainable,

our planet happy.



Our Customer Promise…

Low cost producer

High performance ingredients

Provide a Reliable Supply at a Stable Price

Sustainably produced



Delivering on that Promise to +470 Brands



The Supply Chain Challenge



Volatility is the New Normal

Availability, Cost & Quality of Supply for Sourcing Chemicals

• Oil: Regional Unrest, natural disasters, etc.

• Crops: Drought, Floods, Pests, Food Challenges, etc.

• Ocean Harvesting: Collapsing Fish Stocks, Regulations, etc.



Volatility Due To Changing Market Views

What was acceptable yesterday, may not be tomorrow

• Removing natural resources can seen as exploitive

• Harvesting can be seen as excessive

• Processes such as chemical reactions, catalytic conversion

and cracking often utilize heavy metals and can be viewed as

generating unacceptable pollution / waste



The Supply Chain Opportunity



Delivering Reliable Supply, Lower Cost, Drive Growth

1 2 3Plant/Animal sourced Petroleum sourced Diverse/difficult to

replicate

• Substituting out high Volatility sources found in Nature

• Eliminating complex mfg. chemistry (and the pollution/waste)

• Replacing difficult processes with easier ones

80% of profits



How ?

1Utilize synthetic biology to create yeast strains that produce your molecule

2Utilize yeast strains in industrial scale fermentation to produce your high value chemicals



At What Scale?

• We can produce in excess of 1,250 MT / Mo

• Have run over 8 Molecules (4 in just one year)

• Delivering to our customer’s door high value chemicals / ingredients

In just this plant…



How Fast?BUILD

High ThroughputScreening

AutomatedStrain

Engineering

Tens of KG quantities

300 L

METRIC TONquantities200,000 L

GRAM quantities0.5L & 2L

+ PPS

TS

P450

100,000+ compounds

SCREEN SCALE UP

Using automation and proprietary processes to go from concept to manufacturing in 12 months for most ingredients



Examples of Success



Delivering High Value Supply Across Multiple Markets

Pharmaceuticals

Cosmetics

Currently supplied markets

Flavors & FragrancesPolymers Solvents

LubricantsDiesel

Adhesives & Coatings

Jet Fuel

Selected Consumer Brands

Personal Care Performance Chemicals Industrial


http://www.google.com/url?sa=i&rct=j&q=&esrc=s&frm=1&source=images&cd=&cad=rja&uact=8&ved=0CAcQjRxqFQoTCNyT8YrclMYCFdQujAodHR0FEQ&url=http://www.autoguide.com/auto-news/2014/05/should-i-buy-summer-tires.html&ei=RFqAVdzhENTdsASdupSIAQ&bvm=bv.96041959,d.cWc&psig=AFQjCNHCvizncyhQS1NpnV9ko4xbsCXQxA&ust=1434561458232101

http://www.google.com/url?sa=i&rct=j&q=&esrc=s&frm=1&source=images&cd=&cad=rja&uact=8&ved=0CAcQjRxqFQoTCPzeiYTdlMYCFbhDjAodxCwPsg&url=http://www.mandplabs.com/interface/uploads/images/cache/&ei=QluAVfy1GriHsQTE2byQCw&bvm=bv.96041959,d.cWc&psig=AFQjCNEwjEV0XKmEgOI7k4Wo2Qndkv2oMg&ust=1434561721167718


Putting Yeast to Work Thru Synthetic Biology

• Lubricants: offsets use of Oil,• Cosmetics: offsets use of Olives / Shark livers with low bioavailability,• Solvents: offsets use of Oil,• Fragrances: offsets use of Plants and Laborious Harvests,• Pharmaceuticals: offsets use of Plants with Low Bioavailability,• Jet Fuel: offsets use of Oil and GHG emissions,• Nutraceuticals: offsets use of Oil,

Significantly Improving Availability, Cost Stability AND Quality



Conclusion



What Chemicals in your Supply Chain would Benefit from

• A reliable, sustainable supply,

• Stable, competitive pricing,

• Exceptional quality,

That is good for our planet, good for consumers and good for business

Partnering with Amyris Can Transform Your Supply Chain!Copyright © Amyris, Inc. All rights reserved

putting yeast to work: reducing supply chain volatility

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