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Quality of Care, a global perspective :
The future of quality of care
Kevin De Cock,
CDC Kenya
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Quality of Care, A Global Perspective: The Future of Quality of Care
Kevin M. De Cock, MD
Country Director,
CDC Kenya
2nd EACS Conference
Brussels, November 16-17, 2016
Division of Global HIV/&TB
CDC Kenya
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From Tropical Medicine to Global Health
“People are beginning to
realize that there is nothing in
the world so remote that it
can’t impact you as a person”
William H. Foege
Director, CDC, 1977-1983
Ebola, Zaire 1976
AIDS 1981
IOM Report on EID 1992
“Investing in Health” 1993
World AIDS Conference 1996
WHO Global Action Plan on NCDs 2013
Ebola, West Africa 2014
Paris Climate Change Conference 2015
MDGs World AIDS Conference 2000
PEPFAR SARS 2003
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Tropical Medicine, International Health, or Global Health?
State of the Union Address
January 28, 2003
President Bush announces U.S. President’s
Emergency Plan for AIDS Relief
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Health Impact: Progress Towards MDGs 4 & 5
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Malaria Burden by GNP, and Access to Diagnostics and ACTs, 2015
(WHO, 2016)
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Trends in Tuberculosis in the Era of ART
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Tuberculosis – standardized therapy,
safe therapy, everywhere….
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HIV Science, Policy and Program Convergence
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Differentiated Models of Care for ART
“Client-centred approach that simplifies and adapts HIV services across the cascade to
reflect the preferences and expectations of various groups of people living with HIV
(PLHIV) while reducing unnecessary burdens on the health system. By providing
differentiated care the health system can refocus resources to those most in need.”
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Chronic liver disease
Cognitive disorders
Non-AIDS cancers
Chronic renal disease
Osteoporosis CVD
Frailty
Depression
Diabetes mellitus
COPD
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Leapfrogging
• Cell phones
• E-banking
• Informatics, e-health
• Molecular diagnostics
• Point of care tests
• Vaccines
• Public health approach to ART
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Global Health Post-Ebola and the MDGs – Emerging Issues
Universal health
coverage
Non-communicable
diseases
Emerging and re-
emerging infections
Antimicrobial
resistance
Climate change
Injuries
Source: Emerg Infect Dis 2013;19:1192-1197
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Silver Linings and Gathering Clouds
Economic growth
Security and conflict
Migration
Corruption
Population growth
Environment and
resources
Climate change
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Population Growth and Urbanization
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Towards an AIDS-free Generation
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“By 2030, end the epidemics of AIDS, tuberculosis, malaria and neglected tropical diseases and combat hepatitis, water-borne diseases and other communicable diseases”
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The First “90”
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Identification of PLHIV
Source: NACC&NASCOP, 2014 HIV Estimates; PEPFAR Kenya APR 2015 Analysis
0%
1%
2%
3%
4%
5%
6%
7%
8%
9%
10%
11%
12%
13%
14%
15%
16%
Tota
l
Ho
ma
Bay
Siay
aK
isu
mu
Mig
ori
Nya
mir
aSa
mb
uru
Kw
ale
Bo
met
Nar
ok
Kak
ameg
aTa
ita
Tave
taM
om
bas
aM
ura
ng'
aTu
rkan
aN
aku
ruK
ajia
do
Bar
ingo
We
st P
oko
tLa
ikip
iaK
ilifi
Nai
rob
i Co
un
tyEl
geyo
Mar
akw
etLa
mu
Tan
a R
ive
rM
aku
eni
Vih
iga
Nan
di
Kis
iiM
and
era
Tran
s N
zoia
Bu
ngo
ma
Gar
issa
Nya
nd
aru
aM
ach
ako
sIs
iolo
Waj
irTh
arak
a N
ith
iB
usi
aEm
bu
Ke
rich
oK
iam
bu
Kir
inya
gaK
itu
iM
arsa
bit
Me
ruN
yeri
Uas
in G
ish
u
Comparison of Overall and “Remaining Prevalence” after accounting for PLHIV already in care
prevalence
"remaining prevalence"APR15
• 6.5million tests done
• 3%HIV+ yield
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HIV+ Yield for Different Testing Approaches
113.291
38.268
17.678 15.041 7.528 5.328 5.124 3.918 1.861 1.398 1.220
2,9%
3,0%
3,5% 4,6%
4,6% 2,5%
17,2%
4,3% 1,6% 2,9% 3,7%
0,0%
2,0%
4,0%
6,0%
8,0%
10,0%
12,0%
14,0%
16,0%
18,0%
20,0%
-
20.000
40.000
60.000
80.000
100.000
120.000
Ou
tpat
ien
t D
ep
artm
en
t
VC
T c
o-l
oca
ted
VC
T s
tan
dal
on
e
Inp
atie
nt
VM
MC
Mo
bile
Tub
erc
ulo
sis
HIV
Car
e a
nd
Tre
atm
en
t C
linic
Ho
me
-bas
ed
Oth
er
Serv
ice
De
live
ry P
oin
t
Sexu
ally
Tra
nsm
itte
d In
fect
ion
s
HIV Positive Yield
Source: PEPFAR APR 2015 Analysis
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• Provider-initiated HIV
testing and
counseling
• Assisted Partner
Services (partner
notification)
• Family testing
• Home-based testing
• Community testing
• Self-testing
Maximizing HIV Testing Yield
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The Second “90”
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Standard vs. Same-day ART* 100%
92%
71%
50%
100% 100%
80%
61%
0%
20%
40%
60%
80%
100%
120%
Completed CD4 count Initiated ART Alive and in Care at 12months
Alive with undetectableVL
Standard (285) Same Day (Test /Treat) (279)
Same-day ART initiation was associated with • ART uptake 100% vs 92%, p<0.001
• Improved retention with viral suppression aOR 1.76 (95% CI 1.24-2.49; p=0.002)
• Reduced risk of mortality aOR 0.35 (95% CI 0.14-0.86; p=0.021)
Superior Outcomes with Same-Day HIV Testing
and ART Initiation, Haiti
• *Serena Koenig, et al., GHESKIO, Haiti, AIDS 2016
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Treatment Adherence: Recommendations
WHO Guideline Dissemination Workshop, Johannesburg, South Africa, April 25-29, 2016
Effective interventions Peer counsellors
Mobile phone text
messages
Reminder devices
Cognitive behavioural
therapy
Behavioural skills training
/medication adherence
training
Fixed dose combinations
and once daily regimens
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Differentiated Models of Care for ART
“Client-centred approach that simplifies and adapts HIV services across the cascade to
reflect the preferences and expectations of various groups of people living with HIV
(PLHIV) while reducing unnecessary burdens on the health system. By providing
differentiated care the health system can refocus resources to those most in need.”
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31% 41%
14% 14%
30% 35%
18% 17%
13% 9%
17% 61%
0% 21% 21%
58%
0% 10% 20% 30% 40% 50% 60% 70%
>90 days
31-60 days
>90 days
31-60 days
>90 days
31-60 days
>90 days
31-60 days
5-1
0yr
s2
-5yr
s1
-2yr
s<1
yr
*CHAI Kenya. Cross-sectional Assessment of ART prescription practices, 2016; **PEPFAR Kenya Expenditure Analysis, FY15
Average ART clinic visits, FY15**
• Adults: 4.9 per year
• Peds: 5.1 per year
83%
86%
39%
42%
ART PRESCRIPTION PRACTICES BY DURATION ON TREATMENT*
EVIDENCE OF DIFFERENTIATED CARE MODELS IN KENYA
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Rapid ART Refill for Stable Patients Bomu Hospital, Kenya
Clinician assesses for rapid ART refill eligibility
If eligible, refill prescription (3-6 months)
• Triplicate form (pharmacy, file, patient)
• 3 months maximum dispensed
Refill visit:
• 3 months. Reception and direct to pharmacy
• Advised to come to the clinic if become ill.
• If new WHO stage 3/4, rapid refill suspended
Clinic visit:
• Every 6 months, full review, CD4/VL done
• 3-day return visit for lab review
Source: Bomu Medical Center, 2016
Viral suppression: 88%
EVIDENCE OF DIFFERENTIATED CARE MODELS IN KENYA
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KENYA MODEL OF DIFFERENTIATED CARE
Care of patients beyond First Year of ART
Care of patients within First Year of ART
Advanced HIV Disease
Stable Patients Unstable Patients
WHO Stage 3 or 4
CD4 count ≤ 200
cell/Μl/ (or ≤ 25% for children ≤ 5 years old)
WHO Stage 1 or 2
CD4 count > 200 cell/μL
(or > 25% for children ≤ 5 years old) Eligible for Community
ART Service delivery as a package of Care Weekly follow-up until ART initiation, and then at week 2 and 4 after ART
initiation, and then monthly for the first 6 months of ART
Those who present well
APPROACH BASED ON DURATION OF ART
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CRITERIA FOR A HEALTH FACILITY TO IMPLEMENT A COMMUNITY-BASED ART DISTRIBUTION PROGRAM
Health Information Systems Has a functioning system in place to monitor and report patient-level outcomes
Service Delivery • Uptake of routine VL monitoring is ≥ 90% • Has functional system in place for fast-tracked facility-based ART distribution for stable patients
Commodity Management
• Currently has ≥ 3 months stock of ARV on site • Has capacity (including personnel and supplies) Leadership
Involvement of County Leadership Focal person to oversee distribution Program
Finance To implement and monitor community-based ART distribution
Human Resources
• Appropriate personnel for distributing ART: • Capacity to train and supervise ART
distributors
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• Supply chain issues – increased need for ARV supply
• Patient related issues with bulky prescription
Peer educator collecting ARV drugs at AMPATH Clinic. Photo used with permission
OPERATIONAL ISSUES
Adherence support Rapid referral Retention Program evaluation
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The Third “90”
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Viral Load Testing in Kenya
National Viral Load Testing Labs Rapid scale up of VL Testing:
2015 Jan- Dec: 649,366 (83% viral suppression)
2016 Jan – Aug: 657,610 (84% viral suppression)
Challenges:
Prolonged turnaround time
– Equipment breakdown/downtime
– Commodity stockouts
– HR challenges
– Uneven distribution of workload
Sub-optimal lab-clinical interphase
– Delivery of results to patient files
– Utilization of results by clinicians
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Viral suppression by age, SAPR ‘16
61,0 67,0 65,0 61,0
86,0
39,0 33,0 35,0 39,0 14,0
<5 5 to <10 10 to <15 15 to <18 18+
0%
10%
20%
30%
40%
50%
60%
70%
80%
90%
100%
Age (years)
Su
pp
ressio
n r
ate
s (
% o
f to
tal te
sts
)
Suppressed Not suppressed
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Measuring Progress and
Impact
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90:90:90 Impact
• Program targets, not
impact measures
• Ratios, not rates
• People can drop out and
re-enter
• Need cohort analysis
• Need electronic medical
records
• Critical impact indicators
are HIV incidence and
death, possibly TB trends
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Nairobi Mortuary Study, 2015
“The death rate is a fact,
everything else is an inference”
William Farr, 1807-1883
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Measuring the Cycle of HIV