quick reference table conclusion**** citation † …...2-chloro-p-phenylenediamine sulfate 1 up to...
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Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
1,2-butanediol 1 not in use at the time* IJT 31(S2): 147-168,2012
1,2-hexanediol 1 0.00005 to 10% IJT 31 (S2): 147-168,2012
1-Hydroxyethyl 4,5-Diamino Pyrazole Sulfate 1 safe as an oxidative hair dye Final report 03/2016available from CIR
1-Naphthol 1 up to 3% in haircoloring products
JACT 8(4):749-68,1989 confirmed
12/062,3-Naphthalenediol 1 JACT 7(3):353-57,
19882,4-Diaminophenol 1 0.2% as the free base JACT 13(5):330-43,
1994 confirmed06/09
2,4-Diaminophenol HCl (aka 2,4-DiaminophenolDihydrochloride)
1 0.2% as the free base JACT 13(5):330-43,1994 confirmed
06/092,4-Diaminophenoxyethanol HCl 1 up to 2% Final Amended
Report 12/07Available from CIRJACT 10(1):113-34,
1991 (original report)2,4-Diaminophenoxyethanol Sulfate (amended) 1 up to 2% Final Amended
Report 12/07Available from CIRJACT 10(1):113-34,
1991 (original report)2-Amino-3-Hydroxypyridine 1 Final report 09/2014
available from CIR2-Amino-3-Nitrophenol 1 up to 2% in hair dyes IJT 28(S3): 217-251,
20092-amino-4-hydroxyethylaminoanisole 1 should not be used in cosmetic
products where N-nitrosocompounds may be formed
IJT 32(S1):25-35,2013
2-amino-4-hydroxyethylaminoanisole sulfate 1 should not be used in cosmeticproducts where N-nitroso
compounds may be formed
IJT 32(S1):25-35,2013
2-Amino-4-Nitrophenol 1 concentration not reported * IJT 28(S3): 217-251,2009
2-Amino-4-Nitrophenol Sulfate 1 not in current use * IJT 28(S3): 217-251,2009
2-Amino-5-Nitrophenol 1 not in current use * IJT 28(S3): 217-251,2009
2-Amino-6-Chloro-4-Nitrophenol 1 up to 2% in hair dyes IJT16(S1):131-43,1997
2-Amino-6-Chloro-4-Nitrophenol HCl 1 up to 2% in hair dyes IJT16(S1):131-43,1997
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Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
2-Bromo-2-Nitropropane-1,3-Diol 1 0.1%; may contribute toendogenous nitrosamine
formation; but should not beused under circumstances
where its actions withamines or amides can
result in the formation ofnitrosamines or nitrosamides
JACT 3(3):139-55,1984 (Addendum)JEPT 4(4):47-61,
1980 (Originalreport) confirmed09/03 IJT 25(S2),
2006
2-Chloro-p-Phenylenediamine 1 up to 0.1% JACT 11(4):521-530,1992
2-Chloro-p-Phenylenediamine Sulfate 1 up to 1.0% JACT 11(4):521-530,1992
2-Ethoxy Ethoxy Ethyl Methacrylate 1 safe in nail enhancementproducts when skin contact isavoided; products containing
this ingredient should beaccompanied with directions
to avoid skin contactbecause of the sensitizingpotential of methacrylates
IJT 24(S5):53-100,2005
2-Methyl-5-Hydroxyethylaminophenol 1 up to 5% JACT 9(2):185-202,1990 confirmed
08/062-Methyl Resorcinol 1 up to 2% JACT 5(3):167-
203, 1986 confirmed12/06
2-Nitro-p-Phenylenediamine 1 up to 1% JACT 4 (3):161-202,1985 confirmed
11/03 IJT 25(S2),2006
2-oleamido-1,3-octadecanediol 1 safe as used Final report 03/2015available from CIR
3-Methylamino-4-Nitrophenoxyethanol 1 up to 0.15% IJT 27 (S2): 41-51,2008
3-Nitro-p-Hydroxyethylaminophenol 1 up to 10% in hair coloringproducts (5% after dilution)
IJT 28(S3): 217-251,2009
4-Amino-2-Hydroxytoluene 1 up to 5% JACT 8 (4):569-87,1989 confirmed
04/064-Amino-2-Nitrophenol 1 IJT 28(S3): 217-251,
20094-Amino-3-Nitrophenol 1 up to 9% in hair dyes IJT 28(S3): 217-251,
20094-Amino-m-Cresol 1 up to 0.7% in oxidative and
non-oxidative hair dyesIJT 23(S2):1-22,
20044-Chloro-2-Aminophenol 1 1 Safe ase used in oxidative
hair dyes, but the availabledata are insufficient to
IJT 23(S2):1-22,2004
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Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
support the safety innon-oxidative hair dyes
4-Chlororesorcinol 1 1% in hair dyes JACT 15 (4): 284-94,1996
4-Hydroxypropylamino-3-Nitrophenol 1 up to 2.6% in hair dyes IJT 28(S3): 217-251,2009
4-Methoxy-m- Phenylenediamine 1 carcinogenicity JACT 11(4):381-422,1992
4-Methoxy-m-Phenylenediamine HCl 1 carcinogenicity JACT 11(4):381-422,1992
4-Methoxy-m-Phenylenediamine Sulfate 1 carcinogenicity JACT 11(4):381-422,1992
4-Nitro-m-Phenylenediamine 1 up to 0.2% JACT 4 (3):161-202,1985 confirmed
11/03 IJT 25(S2),2006
5-Amino-4-Chloro-o-Cresol 1 up to 2% in oxidative andnon-oxidative hair dyes
IJT 23(S2):1-22,2004
5-Amino-6-Chloro-o-Cresol 1 up to 2% in oxidative andnon-oxidative hair dyes
IJT 23(S2):1-22,2004
5-Bromo-5-Nitro-1,3-Dioxane 1 0.1%; but should not be usedunder circumstances where itsactions with amines or amidescan result in the formation ofnitrosamines or nitrosamides
JACT 9(2):279-88,1990
6-Amino-m-Cresol 1 up to 2.4% in oxidative andnon-oxidative hair dyes
IJT 23(S2):1-22,2004
6-Amino-o-Cresol 1 Safe as used (up to 0.7%) inoxidative hair dyes, but the
available data are insufficientto support the safety innon-oxidative hair dyes
IJT 23(S2):1-22,2004
6-Hydroxyindole 1 IJT 33(S3):24-35,2014
Acacia Catechu Gum 1 IJT 24(S3):75-118,2005
Acacia Concinna Fruit Extract 1 IJT 24(S3):75-118,2005
Acacia Dealbata Leaf Extract 1 IJT 24(S3):75-118,2005
Acacia Dealbata Leaf Wax 1 IJT 24(S3):75-118,2005
Acacia Decurrens Extract 1 IJT 24(S3):75-118,2005
Acacia Farnesiana Flower/Stem Extract 1 IJT 24 (S3):75-118,2005
Acacia Farnesiana Flower Wax 1 IJT 24(S3):75-118,2005
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Acacia Farnesiana Gum 1 IJT 24(S3):75-118,2005
Acacia Senegal Extract 1 IJT 24(S3):75-118,2005
Acacia Senegal Gum 1 up to 9% for the gum and0.001% for the extract
IJT 24(S3:75-118,2005
Acacia Senegal Gum Extract 1 up to 9% for the gum and0.001% for the extract
IJT 24(S3:75-118,2005
Acetamide MEA (amended) 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
IJT 34(S1): 18-34,2015; JACT
12(3):225-36, 1993(original report); IJT30(S2):73-127, 2011
(re-review)
Acetic Acid 1 0.0003 to 0.3% IJT 31(S4): 112- 136,2012
Acetyl arginine 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Acetylated Lanolin 1 up to 7% JEPT 4(4):63-92,1980 confirmed
02/03 IJT24(S1):2-10, 2005
Acetylated Lanolin Alcohol 1 up to 16% JEPT 4 (4):63-92,1980 confirmed
02/03 IJT24(S1):2-10, 2005
Acetyl Carnitine 1 safe when formulatedto be non- irritating
IJT 31(S3):296-341,2012
Acetyl Carnitine HCl 1 safe when formulatedto be non- irritating
IJT 31(S3):296-341,2012
Acetyl Cysteine 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Acetyl Glutamic acid 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Acetyl Glutamine 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Acetyl Histidine 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Acetyl Methionine 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Acetyl Proline 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Acetyl Tributyl Citrate 1 up to 7% IJT 21 (S2):1-17,2002
Acetyl Triethyl Citrate 1 up to 7% IJT 21 (S2):1-17,2002
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Acetyl Trihexyl Citrate 1 not in current use * IJT 21(S2):1-17,2002
Acetyl Trioctyl Citrate 1 not in current use * IJT 21(S2):1-17,2002
Acetyl Tyrosine 1 safe for use for cosmeticswhen formulated
to be non-irritating
Final report 12/2013available from CIR
Achillea Millefolium Extract 1 safe for use when formulatedto be non-sensitizing
IJT 20(S2):79-84,2001; final report12/2013 available
from CIRAchillea Millefolium Flower/Leaf/Stem Extract 1 safe for use when formulated
to be non-sensitizingFinal report 12/2013
available from CIRAchillea Millefolium Flower Extract 1 safe for use when formulated
to be non-sensitizingFinal report 12/2013
available from CIRAcid Orange 3 1 0.2% in hair dyes IJT 19 (S1):1-9, 2000Acid Violet 43 1 safe for use in hair dye
formulations when free ofimpurities except for the
following: less than or equalto 18% volatile matter (at 135degrees C) and chlorides andsulfates (calculated as sodium
salts); less than or equal to0.4% water-insoluble mat
IJT 20(S3):1-6, 2001
Acrylamide/Ethyltrimonium Chloride* Acrylate/Ethalkonium Chloride Acrylate Copolymer
1 safe in the present practices ofuse and concentration, when
formulated to be non-irritating
IJT 31(S3): 296-341(2012)
Acrylamidopropyl Trimonium Chloride/AcrylamideCopolymer*
1 safe in the present practices ofuse and concentration, when
formulated to be non-irritating
IJT 31(S3): 296-341(2012)
Acrylamidopropyl-Trimonium Chloride/AcrylatesCopolymer
1 safe in the present practices ofuse and concentration, when
formulated to be non-irritating
IJT 31(S3): 296-341(2012)
Acrylates/Ammonium Methacrylate Copolymer 1 safe for use whenformulated to avoid irritation
IJT 21(S3):1-50,2002
Acrylates/bis-hydroxypropyl dimethicone crosspolymer 1 not in current use* IJT 33 (S2): 65-115,2014
Acrylates/C12-13 Alkyl Methacrylates/MethoxyethylAcrylate Crosspolymer
1 safe in the present practices ofuse and concentration whennot polymerized in benzene
Final report 11/2011available from CIR
Acrylates/dimethiconol acrylate copolymer 1 up to 0.5% Final report 12/10available from CIR
Acrylates/Ethylhexyl Acrylate/Glycidyl MethacrylateCrosspolymer
1 safe in the present practices ofuse and concentration whennot polymerized in benzene
Final report 11/2011available from CIR
Acrylates/Ethylhexyl Acrylate/Styrene Copolymer 1 not in current use* Final report 09/2014available from CIR
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Acrylates/Ethylhexyl Acrylate Crosspolymer 1 safe in the present practices ofuse and concentration whennot polymerized in benzene
Final report 11/2011available from CIR
Acrylates/Hydroxyesters Acrylates Copolymer 1 safe for use whenformulated to avoid irritation
IJT 21(S3):1-50,2002
Acrylates/PEG-4 Dimethacrylate Crosspolymer 1 safe in the present practices ofuse and concentration whennot polymerized in benzene
Final report 11/2011available from CIR
Acrylates/PVP Copolymer 1 safe for use whenformulated to avoid irritation
IJT 21(S3):1-50,2002
Acrylates/Steareth-20 Methacrylate Copolymer 1 safe for use whenformulated to avoid irritation
IJT 21(S3):1-50,2002
Acrylates/Steareth-20 Methacrylate Crosspolymer 1 safe in the present practices ofuse and concentration whennot polymerized in benzene
Final report 11/2011available from CIR
Acrylates/Steareth-50 Acrylate Copolymer 1 safe for use whenformulated to avoid irritation
IJT 21(S3):1-50,2002
Acrylates/VA Copolymer 1 safe for use whenformulated to avoid irritation
IJT 21(S3):1-50,2002
Acrylates/Vinyl Isodecanoate Crosspolymer 1 safe in the present practices ofuse and concentration whennot polymerized in benzene
Final report 11/2011available from CIR
Acrylates/Vinyl Neodecanoate Crosspolymer 1 Final report 11/2011available from CIR
Acrylates C10/30 Alkyl Acrylate Crosspolymer 1 1 when used as describedin assessment, 0.0002-5%
data does not support usewhen polymerized in benzene
Final report 11/2011available from CIR
Acrylates Copolymer 1 safe for use whenformulated to avoid irritation
IJT 21(S3):1-50,2002
Acrylates Crosspolymer 1 safe in the present practices ofuse and concentration whennot polymerized in benzene
Final report 11/2011available from CIR
Actinidia Chinensis (Kiwi) Seed Oil 1 up to 0.1% Final report 03/11available from CIR
Adansonia Digitata Oil 1 up to 0.01% Final report 03/11available from CIR
Adansonia Digitata Seed Oil 1 not in current use* Final report 03/11available from CIR
Adansonia digitata seed oil PEG-8 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Adipic Acid 1 0.000001% in leave-on; 18% in rinse- off
IJT 31 (S1):5-76,2012
Adipic acid/1,4 butanediol/terephthalate copolymer 1 not in current use* IJT 33(S3):36-47,2014
Adipic Acid Dihydrazide 1 JACT 13(3):154-6,1994
Agar 1 Final report 09/2015available from CIR
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Agarose 1 Final report 09/2015available from CIR
Alanine 1 3.0 x 10-7 to 0.1% IJT 32(S4):41-64,2013
Alcaligenes polysaccharides 1 0.005 to 0.3% Final report 09/12available from CIR
Alcohol Denat. denatured with Quassin or Brucine 1 IJT 27 (S1):1-43,2008
Alcohol Denat. denatured with t-Butyl Alcohol, DenatoniumBenzoate, Diethyl Phthalate, or Methyl Alcohol
1 up to 99% IJT 27 (S1):1-43,2008
Aldioxa 1 JACT 12(3):237-42,1993
Aleurites Moluccanus Bakoly Seed Oil 1 not in current use* Final report 03/11available from CIR
Aleurites Moluccanus Seed Oil 1 0.00001 to 5% Final report 03/11available from CIR
Algae Exopolysaccharides 1 Final report 09/2015available from CIR
Algin 1 Final report 09/2015available from CIR
Alginic Acid 1 Final report 09/2015available from CIR
Alkyl aryl sulfonate hydrotropes 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 30(Suppl.3):270-283, 2011
Allantoin 1 up to 2% IJT 29(Suppl. 2):84-97, 2010
Allantoin Ascorbate 1 up to 0.05% IJT 29(Suppl. 2):84-97, 2010
Allantoin Biotin 1 not in current use * IJT 29(Suppl. 2):84-97, 2010
Allantoin Galacturonic Acid 1 not in current use * IJT 29(Suppl. 2):84-97, 2010
Allantoin Glycyrrhetinic Acid 1 concentration not reported * IJT 29(Suppl. 2):84-97, 2010
Allantoin Panthenol 1 concentration not reported * IJT 29(Suppl. 2):84-97, 2010
Allantoin Polygalacturonic Acid 1 concentration not reported * IJT 29(Suppl. 2):84-97, 2010
Allyl Methacrylate/Glycol Dimethacrylate Crosspolymer 1 safe in the present practices ofuse and concentration whennot polymerized in benzene
Final report 11/2011available from CIR
Allyl Methacrylates Crosspolymer 1 safe in the present practices ofuse and concentration whennot polymerized in benzene
Final report 11/2011available from CIR
Almondamide DEA 1 safe in the present practices ofuse and concentration when
formulated to be non-irritating
IJT 32(S1):36-58,2013
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
and when the levels of freeDEA do not exceed those
considered safe int the CIRsafety assessment of DEAand its salts; should not beused in cosmetic products
Almondamidopropyl betaine 1 safe in cosmetics as longas they are formulatedto be non-sensitizing,
which may be based on aquantitative risk assessment
IJT 31(S1):77-111,2012
Almondamidopropyl dimethylamine 1 not in current use* safe in cosmetics as longas they are formulatedto be non-sensitizing,
which may be based on aquantitative risk assessment
Final report 06/2014available from CIR
Almond oil PEG-6 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Almond oil PEG-8 Esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Almond Oil Propylene Glycol Esters* 1 safe when formulatedto be non- irritating
Final report 12/2014available from CIR
Aloe Andongensis Extract 1 IJT 26(S2):1-50,2007
Aloe Andongensis Leaf Juice 1 IJT 26(S2):1-50,2007
Aloe Arborescens Leaf Extract 1 IJT 26(S2):1-50,2007
Aloe Arborescens Leaf Juice 1 IJT 26(S2):1-50,2007
Aloe Arborescens Leaf Protoplasts 1 IJT 26(S2):1- 50,2007
Aloe Barbadensis Flower Extract 1 safe as cosmetic ingredientsin the practices of useand concentrations as
described in this safetyassessment, if anthraquinone
levels in the ingredientsdo not exceed 50 ppm.
IJT 26(S2):1-50,2007
Aloe Barbadensis Leaf 1 safe as cosmetic ingredientsin the practices of useand concentrations as
described in this safetyassessment, if anthraquinone
levels in the ingredientsdo not exceed 50 ppm.
IJT 26(S2):1- 50,2007
Aloe Barbadensis Leaf Extract 1 safe as cosmetic ingredientsin the practices of use
IJT 26(S2):1-50,2007
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Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
and concentrations asdescribed in this safety
assessment, if anthraquinonelevels in the ingredientsdo not exceed 50 ppm.
Aloe Barbadensis Leaf Juice 1 safe as cosmetic ingredientsin the practices of useand concentrations as
described in this safetyassessment, if anthraquinone
levels in the ingredientsdo not exceed 50 ppm.
IJT 26(S2):1-50,2007
Aloe Barbadensis Leaf Water 1 safe as cosmetic ingredientsin the practices of useand concentrations as
described in this safetyassessment, if anthraquinone
levels in the ingredientsdo not exceed 50 ppm.
IJT 26(S2):1-50,2007
Aloe Barbadensis Polysaccharides 1 safe as cosmetic ingredientsin the practices of useand concentrations as
described in this safetyassessment, if anthraquinone
levels in the ingredientsdo not exceed 50 ppm.
IJT 26(S2):1-50,2007
Aloe Ferox Leaf Extract 1 IJT 26(S2):1-50,2007
Aloe Ferox Leaf Juice 1 IJT 26(S2):1-50,2007
Aloe Ferox Leaf Juice Extract 1 IJT 26(S2):1-50,2007
Alpha Hydroxy Acids (e.g. Glycolic and Lactic Acid, andtheir salts and esters) (see CIR report of the same name)
Glycolic and Lactic Acid,their common salts and their
simple esters, are safe foruse in cosmetic products
at concentrations less thanor equal to10%, at finalformulation pH greater
than or equal to3.5, whenformulated to avoid increasing
sun sensitivity or whendirections for use include
IJT 17(S1):1-242,1998
Alumina 1 Final report 12/2013available from CIR
Alumina Magnesium Metasilicate 1 up to 0.01% Final Report 09/09available from CIR
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Aluminum Calcium Sodium Silicate 1 up to 6% Final Report 09/09available from CIR
Aluminum Citrate 1 concentration not reported * IJT 33 (S2): 16-46,2014
Aluminum Dimyristate (amended) 1 up to 3% IJT29(S3) :162-186,2010
Aluminum Distearate 1 up to 5% JACT 1(2):143-77, 1982 confirmed
11/01 IJT22(S1):1-35, 2003
Aluminum Hydroxide 1 Final report 12/2013available from CIR
Aluminum Iron Silicates 1 not in current use* Final Report 09/09available from CIR
Aluminum Isostearates/Myristates 1 not in current use * IJT29(S3) :162-186,2010
Aluminum Myristate 1 up to 1% IJT 29(S3) :162-186,2010
Aluminum Myristates/Palmitates 1 up to 6% IJT29(S3) :162-186,2010
Aluminum Silicate 1 up to 37% in dentifrices;up to 3% in other uses
IJT 22(S1):37-102,2003
Aluminum Starch Octenylsuccinate 1 safe as used provided thatestablished limitations
imposed on heavymetal concentrations
are not exceeded
IJT 21(S1):1-7, 2002
Aluminum Stearate 1 up to 8% JACT 1(2):143-77,1982 confirmed
11/01 IJT22(S1):1-35, 2003
Aluminum Tristearate 1 up to 10% JACT 1(2):143 -77,1982 confirmed
11/01 IJT22(S1):1-35, 2003
Amaranthus Hypochondriacus Seed Oil 1 not in current use* Final report 03/11available from CIR
Amino Bispropyl Dimethicone 1 not in current use * IJT 22(S2):11-35,2003
Aminoethyl Propanediol 1 Final report 09/2013available from CIR
Aminomethyl Propanediol (amended) 1 up to 2% IJT 28 (S2):141-1612009 JACT
9(2):203-28, 1990(original report);
final report 09/2013available from CIR
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Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Aminomethyl Propanol (amended) 1 up to 7% IJT 28 (S2):141-1612009 JACT
9(2):203-28, 1990(original report)
Aminopropyl Dimethicone 1 not in current use * IJT 22(S2):11-35,2003
Ammonium Acrylates Copolymer 1 safe for use whenformulated to avoid irritation
IJT 21(S3):1-50,2002
Ammonium Alginate 1 Final report 09/2015available from CIR
Ammonium Bisulfite 1 up to 32% IJT 22(S2):63- 88,2003
Ammonium C12-15 Pareth Sulfate 1 safe in the present practices ofuse and concentration when
formulated to be non-irritating
IJT 29(Suppl.3) :151-161,2010
Ammonium Capryleth Sulfate, 1 safe in the present practices ofuse and concentration when
formulated to be non-irritating
IJT 29(Suppl.3) :151-161,2010
Ammonium Cocomonoglyceride Sulfate (amended) 1 not in current use * IJT 30(S1):5S-16SAmmonium Coco-Sulfate 1 not in current use * IJT 29(S2): 115-132,
2010Ammonium Cocoyl Isethionate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 09/2013
available from CIRAmmonium Cocoyl Sarcosinate 1 safe as used in rinse-off
products; but 5% in leave-on products. Should not beused in products where N-nitroso compounds may beformed. Insufficient data todetermine safety in products
where these ingredientsare likely to be inhaled.
IJT 20(S1):1-14,2001
Ammonium Cumenesulfonate 1 not in current use * IJT 30(S3):270-283,2011
Ammonium Dinonyl Sulfosuccinate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2013available from CIR
Ammonium Dodecylbenzenesulfonate (amended) 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 29 (S4) 288-305,2010
Ammonium Glycolate 1 safe for use in cosmeticproducts at concentrationsless than or equal to10%,at final formulation pH
greater than or equal to3.5,when formulated to avoidincreasing sun sensitivityor when directions for use
include the daily use of sun
IJT 17(S1):1-242,1998
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Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
protection. These ingredientsare safe for use in sal
Ammonium Glycyrrhizate 1 up to 5% IJT 26 (S2):79-112,2007
Ammonium Lactate 1 safe for use in cosmeticproducts at concentrationsless than or equal to10%,at final formulation pH
greater than or equal to3.5,when formulated to avoidincreasing sun sensitivityor when directions for use
include the daily use of sunprotection. These ingredients
are safe for use in sal
IJT 17(S1):1-242,1998
Ammonium Laureth Sulfate 1 safe in the present practices ofuse and concentration when
formulated to be non-irritating
JACT 2(5):1-34,1983 confirmed
11/02 IJT24(S1):85-89,
2005; IJT 29(Suppl.3) :151-161,2010
Ammonium Lauroyl Sarcosinate 1 safe as used in rinse-offproducts; but 5% in leave-on products. Should not beused in products where N-nitroso compounds may beformed. Insufficient data todetermine safety in products
where these ingredientsare likely to be inhaled.
IJT 20(S1):1-14,2001
Ammonium Lauryl Sulfate 1 safe for use in rinse-offproducts; but 1% for leave-on
JACT 2(7):127-81,1983 confirmed
06/02 IJT24(S1):89-98, 2005
Ammonium Myreth Sulfate 1 not in current use * safe in the present practices ofuse and concentration when
formulated to be non-irritating
IJT29(S3) :151-161,2010
Ammonium Myristyl Sulfate 1 not in current use * IJT 29(S2): 115-132,2010
Ammonium Persulfate 1 safe as oxidizing agentsin hair colorants and
lighteners designed forbrief, discontinuous usefollowed by thorough
rinsing from hair and skin
IJT 20(S3):7-21,2001
Ammonium Phosphatidyl Rapeseedate* 1 safe as used Final report 03/2015available from CIR
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Ammonium Polyacrylate 1 safe for use whenformulated to avoid irritation
IJT 21(S3):1-50,2002
Ammonium Stearate 1 up to 10% JACT 1(2):143-77,1982 confirmed
11/01 IJT22(S1):1-35, 2003
Ammonium Styrene/Acrylates Copolymer 1 safe for use whenformulated to avoid irritation
IJT 21(S3):1-50,2002
Ammonium Sulfite 1 not in current use * IJT 22 (S2):63-88,2003
Ammonium Tallate 1 not in current use * IJT 28(S3):252-258,2009
Ammonium Thioglycolate (amended) 1 in hair straighteners,permanent waves, tonics,dressings, etc., wave sets,other non-coloring hairproducts, and hair dyes
and colors; safe at 15.2%(as thioglycolic acid);
hairdressers should avoidskin contact and minimizeconsumer skin exposure
IJT 28(S3):68-133,2009 JACT
10(1):135-92, 1991(original report)
Ammonium VA/Acrylates Copolymer 1 safe for use whenformulated to avoid irritation
IJT 21(S3):1-50,2002
Ammonium Xylenesulfonate 1 up to 3% IJT 30 (S3):270-283,2011
Amodimethicone 1 up to 3% IJT 22(S2):11-35,2003
Amodimethicone Hydroxystearate 1 not in current use * IJT 22(S2):11-35,2003
AMP-Acrylates Copolymer 1 safe for use whenformulated to avoid irritation
IJT 21(S3):1-50,2002
Amyl Acetate 1 up to 10% JACT 7(6):705-19,1988
Amyl Benzoate 1 not in current use * IJT 31 (S3):342-372(2012)
Amylodextrin 1 Final report 09/2015available from CIR
Amylopectin 1 Final report 09/2015available from CIR
Amylose 1 Final report 09/2015available from CIR
Anacardium Occidentale (Cashew) Seed Oil 1 0.002 to 1% Final report 03/11available from CIR
Anthemis nobilis flower extract 1 safe for use in cosmeticswhen formulated tobe non-sensitizing
Final report 12/2013available from CIR
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Anthemis nobilis flower oil 1 safe for use in cosmeticswhen formulated tobe non-sensitizing
Final report 12/2013available from CIR
Anthemis nobilis flower powder 1 safe for use in cosmeticswhen formulated tobe non-sensitizing
Final report 12/2013available from CIR
Anthemis nobilis flower water 1 safe for use in cosmeticswhen formulated tobe non-sensitizing
Final report 12/2013available from CIR
Aphanothece Sacrum Polysaccharide 1 Final report 09/2015available from CIR
Apricotamide DEA 1 safe in the present practices ofuse and concentration when
formulated to be non-irritatingand when the levels of freeDEA do not exceed those
considered safe int the CIRsafety assessment of DEAand its salts; should not beused in cosmetic product
IJT 32(S1):36-58,2013
Apricotamidopropyl betaine 1 safe in cosmetics as longas they are formulatedto be non-sensitizing,
which may be based on aquantitative risk assessment
IJT 31(S1):77-111,2012
Apricot Kernel Amino Acids 1 not in current use * IJT 33(S4):5-12,2014
Apricot Kernel Oil PEG-40 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Apricot Kernel Oil PEG-6 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Apricot Kernel Oil PEG-8 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Apricot Kernel Oil Propylene Glycol Esters* 1 safe when formulatedto be non-irritating
Final report 12/2014available from CIR
Arabinoxylan 1 Final report 09/2015available from CIR
Arachideth-20 1 safe in cosmetics as longas they are formulated
to be non-irritating
IJT 31(S2):169-244(2012)
Arachidonic Acid 1 JACT 12(5):481-559,1993
Arachidyl behenate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
arachidyl erucate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
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Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Arachidyl Glucoside 1 safe in cosmeticswhen formulated
to be non- irritating
IJT 32 (S3): 22-48,2013
Arachidyl Glycol 1 not in use at the time* IJT 31 (S2): 147-168,2012
Arachidyl Propionate 1 up to 10% safe in cosmetics as longas they are formulated
to be non-irritating
JACT 9(2):143-52,1990 confirmed
06/06; Final report03/2013 available
from CIRArctium Lappa Seed Oil 1 not in use at the time* Final report 03/11
available from CIRArgania Spinosa Kernel Oil 1 0.001 to 10% Final report 03/11
available from CIRArgan oil PEG-8 esters 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014Arginine 1 0.00002 to 18% IJT 32(S4):41-64,
2013Arginine HCl 1 0.004 to 0.02% IJT 32(S4):41-64,
2013Arnica Montana 1 IJT 20(S2):1-11,
2001Arnica Montana Extract 1 IJT 20(S2):1-11,
2001Ascorbyl Dipalmitate 1 not in current use * IJT 18(S3):1-26,
1999Ascorbyl Palmitate 1 up to 0.2% IJT 18(S3):1- 26,
1999Ascorbyl Stearate 1 not in current use * IJT 18(S3):1-26,
1999Ascorbyl tocopheryl acetate 1 not in current use * Final report 03/2014
available from CIRAscorbyl tocopheryl maleate 1 Final report 03/2014
available from CIRAsparagine 1 concentration not reported IJT 32(S4):41-64,
2013Aspartic Acid 1 0.000005 to 1% IJT 32(S4):41-64,
2013Astragalus Gummifer Gum 1 JACT 6(1):1-22,
1987 confirmed09/04; Final report09/2015 available
from CIRAstrocaryum Murumuru Seed Butter 1 0.001 to 7% Final report 03/11
available from CIRAttapulgite 1 up to 8% IJT 22(S1):37-102,
2003
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Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Avena Sativa (oat) bran 1 safe when formulatedto be non-sensitizing
Final report 12/2014available from CIR
Avena Sativa (oat) bran extract 1 safe when formulatedto be non-sensitizing
Final report 12/2014available from CIR
Avena Sativa (oat) Flower/leaf/stem Juice* 1 safe when formulatedto be non-sensitizing
Final report 12/2014available from CIR
Avena Sativa (oat) Kernel Extract 1 safe when formulatedto be non- sensitizing
Final report 12/2014available from CIR
Avena Sativa (oat) Kernel Flour 1 safe when formulatedto be non- sensitizing
Final report 12/2014available from CIR
Avena Sativa (oat) Kernel Meal 1 safe when formulatedto be non- sensitizing
Final report 12/2014available from CIR
Avena Sativa (Oat) Kernel Oil 1 0.01 to 3% Final report 03/11available from CIR
Avena Sativa (oat) Kernel Protein 1 safe when formulatedto be non- sensitizing
Final report 12/2014available from CIR
Avena Sativa (oat) Leaf/stalk Extract* 1 safe when formulatedto be non-sensitizing
Final report 12/2014available from CIR
Avena Sativa (oat) Leaf/stem Extract* 1 safe when formulatedto be non-sensitizing
Final report 12/2014available from CIR
Avena Sativa (oat) Leaf Extract 1 safe when formulatedto be non- sensitizing
Final report 12/2014available from CIR
Avena Sativa (oat) Meal Extract 1 safe when formulatedto be non- sensitizing
Final report 12/2014available from CIR
Avena Sativa (oat) Meristem Cell Extract 1 Final report 12/2014available from CIR
Avena Sativa (oat) Peptide 1 safe when formulatedto be non- sensitizing
Final report 12/2014available from CIR
Avena Sativa (oat) Protein Extract 1 safe when formulatedto be non- sensitizing
Final report 12/2014available from CIR
Avena Sativa (oat) Seed Extract* 1 safe when formulatedto be non- sensitizing
Final report 12/2014available from CIR
Avena Sativa (oat) Seed Water* 1 safe when formulatedto be non- sensitizing
Final report 12/2014available from CIR
Avena Sativa (oat) Sprout Oil* 1 safe when formulatedto be non- sensitizing
Final report 12/2014available from CIR
Avena Sativa (Oat) Starch 1 Final report 09/2015available from CIR
Avena Sativa (oat) Straw Extract 1 safe when formulatedto be non- sensitizing
Final report 12/2014available from CIR
Avocadamide DEA 1 safe in the present practices ofuse and concentration when
formulated to be non-irritatingand when the levels of freeDEA do not exceed those
considered safe int the CIRsafety assessment of DEA
IJT 32(S1):36-58,2013
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
and its salts; should not beused in cosmetic products
Avocadamidopropyl betaine 1 safe in cosmetics as longas they are formulatedto be non-sensitizing,
which may be based on aquantitative risk assessment
IJT 31(S1):77-111,2012
Avocadamidopropyl dimethylamine 1 not in current use * safe in cosmetics as longas they are formulatedto be non-sensitizing,
which may be based on aquantitative risk assessment
Final report 06/2014available from CIR
Avocado Oil 1 0.0001 to 98% JEPT 4(4):93-103,1980 confirmed
06/01 IJT22(S1):1-35, 2003
Avocado oil PEG-11 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Avocado oil PEG-8 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Avocado Oil Propylene Glycol Esters* 1 safe when formulatedto be non-irritating
Final report 12/2014available from CIR
Azelaic acid 1 up to 0.3% in leave-on;up to 10% in rinse- off
IJT 31 (S1):5-76,2012
Azelamide MEA 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
IJT 34(S1): 18-34,2015
Azulene 1 IJT 18(S3):27-32,1999
Babassu Acid 1 not in current use* Final report 03/11available from CIR
Babassuamide DEA 1 safe in the present practices ofuse and concentration when
formulated to be non-irritatingand when the levels of freeDEA do not exceed those
considered safe int the CIRsafety assessment of DEAand its salts; should not beused in cosmetic products
IJT 32(S1):36-58,2013
Babassuamide MEA 1 safe in the present practicesof use and concentration(rinse-off products only)
IJT 34(S1): 18-34,2015
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
Babassuamidopropyl betaine 1 safe in cosmetics as longas they are formulatedto be non-sensitizing,
which may be based on aquantitative risk assessment
IJT 31(S1):77-111,2012
Babussuamidopropyl dimethylamine 1 not in current use* safe in cosmetics as longas they are formulatedto be non-sensitizing,
which may be based on aquantitative risk assessment
Final report 06/2014available from CIR
Barium Sulfate 1 safe in cosmetics as longas they are formulated
to be non-irritating
Final report 06/2014available from CIR
Basic Blue 99 1 up to 2% IJT 26(S2):51-63,2007
Basic Violet 1 1 IJT 28(S3):193-204.2009
Basic Violet 3 1 IJT 28(S3):193-204.2009
Basic Violet 4 1 IJT 28(S3):193-204.2009
Bassia Butyracea Seed Butter 1 not in current use* Final report 03/11available from CIR
Bassia Latifolia Seed Butter 1 0.001 to 2% Final report 03/11available from CIR
Batyl Alcohol 1 0.03 to 3% IJT 32 (S3): 5-21,2013
Batyl Isostearate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Batyl Stearate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Beeswax 1 up to 56% JACT 3(3):1-41,1984 confirmed
06/03 IJT24(S1):48-52, 2005
Behenamide DEA 1 safe in the present practices ofuse and concentration when
formulated to be non-irritatingand when the levels of freeDEA do not exceed those
considered safe int the CIRsafety assessment of DEA
IJT 32(S1):36-58,2013
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
and its salts; should not beused in cosmetic products
Behenamide MEA 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
IJT 34(S1): 18-34,2015
Behenamidopropyl betaine 1 safe in cosmetics as longas they are formulatedto be non-sensitizing,
which may be based on aquantitative risk assessment
IJT 31(S1):77-111,2012
Behenamidopropyl dimethylamine 1 safe in cosmetics as longas they are formulatedto be non-sensitizing,
which may be based on aquantitative risk assessment
Final report 06/2014available from CIR
Beheneth-10 1 safe in cosmetics as longas they are formulated
to be non-irritating
IJT 31(S2):169-244(2012)
Beheneth-15 1 safe in cosmetics as longas they are formulated
to be non-irritating
IJT 31(S2):169-244(2012)
Beheneth-2 1 safe in cosmetics as longas they are formulated
to be non-irritating
IJT 31(S2):169-244(2012)
Beheneth-20 1 safe in cosmetics as longas they are formulated
to be non-irritating
IJT 31(S2):169-244(2012)
Beheneth-25 1 safe in cosmetics as longas they are formulated
to be non-irritating
IJT 31(S2):169-244(2012)
Beheneth-30 1 safe in cosmetics as longas they are formulated
to be non-irritating
IJT 31(S2):169-244(2012)
Beheneth-5 1 safe in cosmetics as longas they are formulated
to be non-irritating
IJT 31(S2):169-244(2012)
Behenoxy Dimethicone 1 IJT 22(S2):11-35,2003; Final report12/2014 available
from CIRBehenoxy PEG-10 Dimethicone* 1 Final report 12/2014
available from CIR
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Behentrimonium chloride 1 safe when formulatedto be non- irritating
IJT 31(S3): 296-341(2012)
Behentrimonium methosulfate 1 safe when formulatedto be non- irritating
IJT 31(S3): 296-341(2012)
Behenyl/Isostearyl Beeswax 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Behenyl Alcohol 1 up to 50% JACT 7(3):359-413,1988 confirmed
12/05Behenyl Beeswax 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIRBehenyl Behenate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIRBehenyl Benzoate 1 not in current use* IJT 31 (S3):342-372
(2012)Behenyl Betaine 1 Up to 8.4% safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2014
available from CIRBehenyl dimethicone/bis-vinyldimethicone crosspolymer 1 0.005 to 10% IJT 33 (S2): 65-115,
2014Behenyl Erucate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIRBehenyl Isostearate 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIRBehenyl Olivate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIRBentonite 1 12-80% in mud packs;
up to 8% for other usesIJT 22(S1):37-102,
2003Benzaldehyde 1 up to 0.5% IJT 25(S1):11- 27Benzalkonium Chloride 1 0.1% free active ingredient JACT 8(4):589-625,
1989 confirmed06/06
Benzalkonium Montmorillonite* 1 safe as used when formulatedto be non-irritating
Final report 03/2016available from CIR
Benzalkonium Sepiolite* 1 safe as used when formulatedto be non-irritating
Final report 03/2016available from CIR
Benzethonium Chloride 1 0.5% skin; 0.02% eye area JACT 4(5):65-106,1985 confirmed
03/04 IJT 25(S2),2006
Benzoic Acid 1 0.000002 to 5% Final amended report10/11; original IJT
20(S3):23-50, 2001Benzophenone-1 1 up to 2% JACT 2(5):35-77,
1983 confirmed09/02 IJT
24(S1):10-18, 2005
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Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Benzophenone-11 1 up to 0.2% JACT 2(5):79-84,1983 confirmed
09/02 IJT24(S1):10-18, 2005
Benzophenone-2 1 up to 6% JACT 2(5):79-84,1983 confirmed
09/02 IJT24(S1):10-18, 2005
Benzophenone-3 1 up to 7% JACT 2(5):35-77,1983 confirmed
09/02 IJT24(S1):10-18, 2005
Benzophenone-4 1 up to 2.5% JACT 2(5):79-84,1983 confirmed
09/02 IJT24(S1):10-18, 2005
Benzophenone-5 1 up to 0.3% JACT 2(5):35-77,1983 confirmed
09/02 IJT24(S1):10-18, 2005
Benzophenone-6 1 up to 0.3% JACT 2(5):35-77,1983 confirmed
09/02 IJT24(S1):10-18, 2005
Benzophenone-8 1 up to 0.2% JACT 2(5):79-84,1983 confirmed
09/02 IJT24(S1):10-18, 2005
Benzophenone-9 1 up to 0.4% JACT 2(5):79-84,1983 confirmed
09/02 IJT24(S1):10-18, 2005
Benzoxiquine 1 IJT 16(S1):117-22,1997
Benzyl Alcohol (amended) 1 0.000006 to 10% amended report 10/11IJT 20(S3):23-50,
2001 (original report)Benzyl Benzoate 1 0.000005 to 4% Final report 10/11
available from CIRBenzylparaben (amended) 1 up to 0.4% if used alone;
parabens mixture up to 0.8%IJT 27(S4): 1-82,
2008 JACT 5(5):301-307, 1986
(original report)Bertholletia Excelsa Seed Oil 1 0.0003 to 0.5% Final report 03/11
available from CIRbertholletia excelsa seed oil PEG-8 esters 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014
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Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Beta-glucan 1 0.000001 to 0.1% Final report 09/12available from CIR
Beta-glucan hydroxypropyltrimonium chloride 1 not in current use* Final report 09/12available from CIR
Beta-glucan palmitate 1 not in current use* Final report 09/12available from CIR
Betaine 1 0.0001 to 8.7% safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2014available from CIR
Beta-sitosterol 1 Final report 12/2013available from CIR
Beta-sitosteryl acetate 1 Final report 12/2013available from CIR
BHA 1 up to 0.2% JACT 3(5):83-146,1984
BHT 1 up to 0.5% IJT 21(S2):19-94,2002
Biosaccharide gum-1 1 0.002 to 6% Final report 09/12available from CIR
Biosaccharide gum-2 1 1% Final report 09/12available from CIR
Biosaccharide gum-3 1 not in current use* Final report 09/12available from CIR
Biosaccharide gum-4 1 0.00001 to 5% Final report 09/12available from CIR
Biosaccharide gum-5 1 not in current use* Final report 09/12available from CIR
Biotin 1 up to 1% IJT 20(S4):1-12,2001
Bis (tripeptide-1) copper acetate 1 not in current use* Final report 06/2014available from CIR
Bisabolol 1 up to 1% IJT 18(S3):33-40,1999
Bis-cetyl/PEG-8 Cetyl PEG-8 Dimethicone* 1 Final report 12/2014available from CIR
Bis-diglyceryl Polyacyladipate-1 1 0.2 to 10% IJT 32(S3):56-64,2013
Bis-diglyceryl Polyacyladipate-2 1 0.1 to 36% IJT 32(S3):56-64,2013
Bis-hydroxyethoxypropyl Dimethicone 1 Final report 12/2014available from CIR
Bis-isobutyl PEG/PPG-10/7/dimethicone Copolymer* 1 Final report 12/2014available from CIR
Bis-isobutyl PEG-13/dimethicone Copolymer* 1 Final report 12/2014available from CIR
Bis-isobutyl PEG-24/PPG-7/dimethicone Copolymer* 1 Final report 12/2014available from CIR
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Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Bis-PEG/PPG-14/14 Dimethicone 1 Final report 12/2014available from CIR
Bis-PEG/PPG-15/5 Dimethicone* 1 Final report 12/2014available from CIR
Bis-PEG/PPG-16/16 PEG/PPG-16/16 Dimethicone 1 Final report 12/2014available from CIR
Bis-PEG/PPG-18/6 Dimethicone* 1 Final report 12/2014available from CIR
Bis-PEG/PPG-20/20 Dimethicone 1 Final report 12/2014available from CIR
Bis-PEG/PPG-20/5 PEG/PPG-20/5 Dimethicone* 1 Final report 12/2014available from CIR
Bis-PEG-10 Dimethicone* 1 Final report 12/2014available from CIR
Bis-PEG-12 Dimethicone 1 Final report 12/2014available from CIR
Bis-PEG-12 Dimethicone Beeswax 1 Final report 12/2014available from CIR
Bis-PEG-12 Dimethicone Candelillate 1 Final report 12/2014available from CIR
Bis-PEG-15 Methyl Ether Dimethicone 1 Final report 12/2014available from CIR
Bis-PEG-1 Dimethicone* 1 Final report 12/2014available from CIR
Bis-PEG-20 Dimethicone* 1 Final report 12/2014available from CIR
Bis-PEG-4 Dimethicone 1 Final report 12/2014available from CIR
Bis-PEG-8 Dimethicone* 1 Final report 12/2014available from CIR
Bis-PEG-8 PEG-8 Dimethicone* 1 Final report 12/2014available from CIR
Bis-phenylisopropyl phenylisopropyl dimethicone/vinyldimethicone crosspolymer
1 not in current use* IJT 33 (S2): 65-115,2014
Bis-stearoxy Dimethicone* 1 Final report 12/2014available from CIR
Bis-stearoxyethyl Dimethicone* 1 Final report 12/2014available from CIR
Bis-vinyldimethicone/bis-isobutyl PPG-20 crosspolymer 1 not in current use* IJT 33 (S2): 65-115,2014
Bis-vinyldimethicone/ PEG-10 dimethicone crosspolymer 1 not in current use* IJT 33 (S2): 65-115,2014
Bis-vinyldimethicone/PPG-20 crosspolymer 1 not in current use* IJT 33 (S2): 65-115,2014
Bis-vinyldimethicone crosspolymer 1 not in current use* IJT 33 (S2): 65-115,2014
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Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Borage Seed Oil PEG-8 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Borago Officinalis Seed Oil 1 0.001 to 1% Final report 03/11available from CIR
Boric Acid 1 5%; but not safe for useon infant or injured skin
JACT 2(7):87-125,1983 confirmed
06/03Boron Nitride 1 Final report 06/13
available from CIRBrassica Campestris (Rapeseed) Sterols 1 Final report 12/2013
available from CIRBrassica Campestris (Rapeseeed) Oil Unsaponifiables 1 not in current use* Final report 03/11
available from CIRBrassica Campestris (Rapeseeed) Seed Oil 1 0.007 to 17% Final report 03/11
available from CIRBrassicamidopropyl dimethylamine 1 safe for use in cosmetics
when formulated to be non-irritating, which may bebased on a quantatitiverisk assessment (QRA)
Final report 06/2014available from CIR
Brassica Napus Seed Oil 1 not in current use* Final report 03/11available from CIR
Brassica Oleracea Acephala Seed Oil 1 not in current use* Final report 03/11available from CIR
Brassica Oleracea Italica (Broccoli) Seed Oil 1 0.001 to 3% Final report 03/11available from CIR
Brucine (denaturant) 1 IJT 27 (S1):1-43,2008
Brucine Sulfate (denaturant) 1 IJT 27 (S1):1-43,2008
Butene/propylene copolymer* 1 safe as used Final report 06/2015available from CIR
Butoxyethanol 1 up to 10% in hairand nail products
JACT 15(6):462-526,1996 confirmed
02/02 IJT24(S1):18-20, 2005
Butoxyethyl Acetate 1 not in use at the time* IJT 31(S1):112-136,2012
Butyl Acetate 1 up to 72% JACT 8(4):681-705,1989 confirmed
08/06Butyl Acrylate/Glycol Dimethacrylate Crosspolymer 1 safe in the present practices of
use and concentration whennot polymerized in benzene
Final report 11/2011available from CIR
Butyl acrylate/styrene copolymer 1 Final report 09/2014available from CIR
Butylated Hydroxyanisole (now BHA) 0 up to 0.2% JACT 3(5):83-146,1984 confirmed
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
09/03 IJT 25(S2),2006
Butylated Hydroxytoluene (now BHT) 0 up to 0.5% IJT 21(S2):19-94,2002
Butyl Avocadate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Butyl Babassuate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Butyl Benzoate 1 not in use at the time* IJT 31(S3):342-372(2012)
Butyl Benzyl Phthalate 1 less than 1% JACT 11 (1):1-23,1992; IJT
30(S2):73-127, 2011Butyldimethicone methacrylate/methyl methacrylatecrosspolymer
1 not in current use* IJT 33 (S2): 65-115,2014
Butylene/ethylene/propylene copolymer 1 safe as used Final report 06/2015available from CIR
Butylene/ethylene/styrene copolymer 1 Final report 09/2014available from CIR
Butylene/ethylene copolymer 1 safe as used Final report 06/2015available from CIR
Butylene Glycol 1 0.00007 to 89% JACT 4(5):223 -48,1985 confirmed
02/04 IJT 25(S2),2006
Butylene Glycol Cocoate 1 up to 2% IJT 30 (S1):5S-16S,2011
Butylene Glycol Diisononanoate 1 17% IJT 30 (S3):228-269,2011
Butyl Ester of PVM/MA Copolymer 1 up to 14% Amended FinalReport 06/09
Available from CIRJACT 12(3):243-56,
1993 (original report)Butyl Glucoside 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 32 (S3): 22-48,
2013Butyl Glycolate 1 safe for use in cosmetic
products at concentrationsless than or equal to10%,at final formulation pH
greater than or equal to3.5,when formulated to avoidincreasing sun sensitivityor when directions for use
include the daily use of sunprotection. These ingredients
are safe for use in sal
IJT 17(S1):1-242,1998
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Butyl Isostearate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Butyl Lactate 1 safe for use in cosmeticproducts at concentrationsless than or equal to10%,at final formulation pH
greater than or equal to3.5,when formulated to avoidincreasing sun sensitivityor when directions for use
include the daily use of sunprotection. These ingredients
are safe for use in sal
IJT 17(S1):1-242,1998
Butyl Methacrylate 1 safe in nail enhancementproducts when skin contact isavoided; products containing
this ingredient should beaccompanied with directions
to avoid skin contactbecause of the sensitizingpotential of methacrylates
IJT 24(S5):53-100,2005
Butyl Myristate (amended) 1 safe for use in cosmetics whenformulated to be non-irritating
amended IJT 29(S3):162-86, 2010;original JACT
9(2):247-58, 1990;final report 03/2013available from CIR
Butyloctyl Beeswax 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Butyloctyl Behenate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Butyloctyl Benzoate 1 not in use at the time* IJT 31(S3):342-372(2012)
Butyloctyl Candelillate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Butyloctyl Cetearate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Butyloctyl Oleate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Butyloctyl Palmitate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Butyloctyl Salicylate 1 safe when formulated toavoid irritation and to avoidincreasing sun sensitivity,
or when increased sunsensitivity would be expected,directions for use include thedaily use of sun protection.
IJT 22(3):1-108
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Butyl Oleate 1 safe for use in cosmeticswhen formulated
to be non- irritating
Final report 03/2013available from CIR
Butylparaben (amended) 1 up to 0.4% if used alone;parabens mixture up to 0.8%
IJT 27(S4): 1-82,2008 JACT
3(5):147-209, 1984(original report)
Butyl Stearate 1 up to 9% safe for use in cosmetics whenformulated to be non-irritating
JACT 4(5):107-46,1985 confirmed
06/03 IJT24(S1):21-25, 2005;final report 03/2013available from CIR
Butyl Thioglycolate 1 in hair straighteners,permanent waves, tonics,dressings, etc., wave sets,other non-coloring hairproducts, and hair dyes
and colors; safe at 15.2%(as thioglycolic acid);
hairdressers should avoidskin contact and minimizeconsumer skin exposure
IJT 28(S3):68-133,2009
Butyrospermum Parkii (Shea) Butter 1 0.0005 to 60% Final report 03/11available from CIR
Butyrospermum Parkii (Shea) Butter Unsaponifiables 1 0.06 to 3% Final report 03/11available from CIR
Butyrospermum Parkii (Shea) Oil 1 0.01 to 15% Final report 03/11available from CIR
C10-11 isoparaffin 1 safe when formulatedto be non- irritating
IJT 31(S3): 269-295(2012)
C10-12 isoparaffin 1 safe when formulatedto be non- irritating
IJT 31(S3): 269-295(2012)
C10-13 isoparaffin 1 safe when formulatedto be non- irritating
IJT 31(S3): 269-295(2012)
C10-16 Alkyl Glucoside 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 32 (S3): 22-48,2013
C10-16 Pareth-1 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C10-16 Pareth-2 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C10-40 Isoalkyl acid Octododecanol Esters 1 not in current use* safe as used in cosmeticswhen formulated
to be non-irritating
Final report 03/2013available from CIR
C10-40 Isoalkyl acid phytosterol esters 1 Final report 12/2013available from CIR
C11-12 isoparaffin 1 safe when formulatedto be non- irritating
IJT 31(S3): 269-295(2012)
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Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
C11-13 isoparaffin 1 safe when formulatedto be non- irritating
IJT 31(S3): 269-295(2012)
C11-13 Pareth-10 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C11-13 Pareth-6 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C11-13 Pareth-9 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C11-14 isoparaffin 1 safe when formulatedto be non- irritating
IJT 31(S3): 269-295(2012)
C11-15 Pareth-12 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C11-15 Pareth-15 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C11-15 Pareth-20 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C11-15 Pareth-3 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C11-15 Pareth-30 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C11-15 Pareth-40 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C11-15 Pareth-5 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C11-15 Pareth-7 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C11-15 Pareth-9 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C11-15 Sec-Pareth-12 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244,2012
C11-21 Pareth-10 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C11-21 Pareth-3 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C12-13 alkyl ethylhexanoate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
C12-13 Pareth-1 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C12-13 Pareth-10 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C12-13 Pareth-15 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C12-13 Pareth-2 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C12-13 Pareth-23 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
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Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
C12-13 Pareth-3 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C12-13 Pareth-4 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C12-13 Pareth-5 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C12-13 Pareth-6 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C12-13 Pareth-7 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C12-13 Pareth-9 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C12-14 isoparaffin 1 safe when formulatedto be non- irritating
IJT 31(S3): 269-295(2012)
C12-14 Pareth-12 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C12-14 Pareth-3 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C12-14 Pareth-5 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C12-14 Pareth-7 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C12-14 Pareth-9 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C12-14 Sec-Pareth-12 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244,2012
C12-14 Sec-Pareth-15 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244,2012
C12-14 Sec-Pareth-20 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244,2012
C12-14 Sec-Pareth-3 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244,2012
C12-14 Sec-Pareth-30 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244,2012
C12-14 Sec-Pareth-40 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244,2012
C12-14 Sec-Pareth-5 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244,2012
C12-14 Sec-Pareth-50 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244,2012
C12-14 Sec-Pareth-7 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244,2012
C12-14 Sec-Pareth-8 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244,2012
C12-14 Sec-Pareth-9 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244,2012
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
C12-15 Alkyl Benzoate 1 0.0008 to 59% IJT 31 (3):342-372(2012)
C12-15 alkyl ethylhexanoate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
C12-15 Alkyl Salicylate 1 safe when formulated toavoid irritation and to avoidincreasing sun sensitivity,
or when increased sunsensitivity would be expected,directions for use include thedaily use of sun protection.
IJT 22(3):1-108
C12-15 Pareth-10 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C12-15 Pareth-11 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C12-15 Pareth-12 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C12-15 Pareth-2 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C12-15 Pareth-3 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C12-15 Pareth-5 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C12-15 Pareth-7 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C12-15 Pareth-9 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C12-16 Pareth-5 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C12-16 Pareth-7 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C12-16 Pareth-9 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C12-18 Alkyl Glucoside 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 32 (S3): 22-48,2013
C12-20 Alkyl Glucoside 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 32 (S3): 22-48,2013
C12-20 isoparaffin 1 safe when formulatedto be non- irritating
IJT 31(S3): 269-295(2012)
C13-14 isoparaffin 1 safe when formulatedto be non- irritating
IJT 31(S3): 269-295(2012)
C13-15 Pareth-21 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C13-16 isoparaffin 1 safe when formulatedto be non- irritating
IJT 31(S3): 269-295(2012)
C14-15 Pareth-11 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
C14-15 Pareth-12 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C14-15 Pareth-13 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C14-15 Pareth-4 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C14-15 Pareth-7 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C14-15 Pareth-8 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C14-18 alkyl ethylhexanoate 1 not in current use * safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
C14-18 glycol 1 not in use at the time* IJT 31 (S2): 147-168,2012
C14-30 Alkyl Beeswax 1 not in current use * safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
C15-18 glycol 1 concentration not reported* IJT 31 (S2): 147-168,2013
C15-35 isoparaffin/isoalkylcycloalkanes 1 safe when formulatedto be non-irritating
IJT 31(S3): 269-295(2012)
C16-17 Alkyl Benzoate 1 not in current use * IJT 31(3):342-372(2012)
C16-22 Acid Amide MEA 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
IJT 34(S1): 18-34,2015
C16-36 alkyl stearate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
C18-22 hydroxyalkyl hydroxypropyl guar 1 not in current use* IJT 34(S1): 35-65,2015
C18-30 glycol 1 not in use at the time* IJT 31 (S2): 147-168,2014
C18-38 Alkyl Beeswax 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
C18-38 Alkyl C24-54 Acid Ester 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
C18-70 isoparaffin 1 safe when formulatedto be non- irritating
IJT 31(S3): 269-295(2012)
C20-22 Alkyl Glucoside 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 32 (S3): 22-48,2013
C20-22 Alkyl phosphate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2014available from CIR
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
C20-30 glycol 1 not in use at the time* IJT 31 (S2): 147-168,2015
C20-40 Alkyl Behenate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
C20-40 Alkyl Stearate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
C20-40 isoparaffin 1 safe when formulatedto be non- irritating
IJT 31(S3): 269-295(2012)
C20-40 Pareth-95 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C22-24 Pareth-33 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C24-28 Alkyl Methicone 1 not in current use * IJT 22(S2):11-35,2003
C30-45 alkyl cetearyl dimethicone crosspolymer 1 0.2 to 4% IJT 33 (S2): 65-115,2014
C30-45 Alkyl Dimethicone 1 2% IJT 22(S2):11-35,2003
C30-45 alkyl dimethicone/ polycyclohexene oxidecrosspolymer
1 concentration not reported * IJT 33 (S2): 65-115,2014
C30-45 Alkyl Methicone 1 not in current use * IJT 22(S2):11-35,2003
C30-50 Alkyl Beeswax 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
C30-50 Alkyl Stearate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
C30-50 Pareth-10 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C30-50 Pareth-3 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C30-50 Pareth-40 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C32-36 Isoalkyl Stearate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
C40-60 Alkyl Stearate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
C40-60 Pareth-10 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C40-60 Pareth-3 and -10 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C4-24 alkyl dimethicone/ divinyldimethicone crosspolymer 1 2% IJT 33 (S2): 65-115,2014
C4-5 Isoalkyl Cocoate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
C4-6 Olefin/styrene copolymer 1 not in current use* Final report 09/2014available from CIR
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
C5-6 Olefin/styrene copolymer 1 not in current use* Final report 09/2014available from CIR
C7-8 isoparaffin 1 safe when formulatedto be non- irritating
IJT 31(S3): 269-295(2012)
C8-10 alkyl ethyl phosphate 1 not in current use * safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2014available from CIR
C8-22 Alkyl Acrylates/Methacrylic Acid Crosspolymer 1 safe in the present practices ofuse and concentration whennot polymerized in benzene
Final report 11/2011available from CIR
C8-9 isoparaffin 1 safe when formulatedto be non- irritating
IJT 31(S3): 269-295(2012)
C9-11 isoparaffin 1 safe when formulatedto be non- irritating
IJT 31(S3): 269-295(2012)
C9-11 Pareth-3 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
C9-11 Pareth-4 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
C9-11 Pareth-6 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
C9-11 Pareth-8 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
C9-12 isoparaffin 1 safe when formulatedto be non- irritating
IJT 31(S3): 269-295(2012)
C9-13 isoparaffin 1 safe when formulatedto be non- irritating
IJT 31(S3): 269-295(2012)
C9-14 isoparaffin 1 safe when formulatedto be non- irritating
IJT 31(S3): 269-295(2012)
C9-15 alkyl phosphate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2014available from CIR
C9-15 Pareth-8 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
C9-16 isoparaffin 1 safe when formulatedto be non- irritating
IJT 31(S3): 269-295(2012)
Caesalpinia spinosa gum 1 0.002 to 0.5% IJT 34(S1): 35-65,2015
Caesalpinia spinosa hydroxypropyltrimonium chloride 1 not in current use * IJT 34(S1): 35-65,2015
Calcium/Sodium PVM/MA Copolymer (amended) 1 concentration not reported * Amended FinalReport 06/09
Available from CIRJACT 12(3):243-56,
1993 (original report)
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Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Calcium Acetate 1 concentration not reported * IJT 31(S1):112-136,2012
Calcium Alginate 1 Final report 09/2015available from CIR
Calcium Aluminum Borosilicate 1 0.001 to 33% IJT 32(S3): 65-72,2013
Calcium Ascorbate 1 not in current use * IJT 24(2):51-111,2005
Calcium Aspartate 1 not in current use * IJT 32(S4):41-64,2013
Calcium Benzoate 1 0.002 to 0.004% Amended final report09/11 available from
CIRCalcium Carboxymethyl Cellulose 1 not in use at the time* IJT 5 (3): 1-59, 1986
(original report);Amended safety
assessment 03/09 -Available from CIR
Calcium Carrageenan 1 Final report 09/2015available from CIR
Calcium citrate 1 not in use at the time* IJT 33 (S2): 16-46,2014
Calcium Disodium EDTA 1 not in current use * IJT 21(S2):95-142,2002
Calcium Dodecylbenzenesulfonate (amended) 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 29 (S4) 288-305,2010
Calcium Gluconate 1 Final report 03/2014available from CIR
Calcium Glycinate 1 3% IJT 32(S4):41-64,2013
Calcium Glycolate 1 Glycolic and Lactic Acid,their common salts and their
simple esters, are safe foruse in cosmetic products
at concentrations less thanor equal to10%, at finalformulation pH greater
than or equal to 3.5, whenformulated to avoid increasing
sun sensitivity or whendirections for use include
IJT 17(S1):1-242,1998
Calcium Hydroxide 1 safe in hair straighteners anddepilatories under conditionsof recommended use: users
should minimize skin contact;all other uses safe when
formulated to be non-irritating
Final report 12/2015available from CIR
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Calcium Lactate 1 Glycolic and Lactic Acid,their common salts and their
simple esters, are safe foruse in cosmetic products
at concentrations less thanor equal to10%, at finalformulation pH greater
than or equal to3.5, whenformulated to avoid increasing
sun sensitivity or whendirections for use include
IJT 17(S1):1-242,1998
Calcium Lauroyl Taurate 1 when formulatedto be non-irritating
Final Report 12/2015available from CIR
Calcium Myristate 1 not in use at the time* IJT29(S3) :162-186,2010
Calcium PCA 1 safe as used; shouldnot be used in cosmetic
products in which N-nitrosocompounds can be formed
Final report 12/2014available from CIR
Calcium Salicylate 1 safe when formulated toavoid irritation and to avoidincreasing sun sensitivity,
or when increased sunsensitivity would be expected,directions for use include thedaily use of sun protection.
IJT 22(3):1-108
Calcium Silicate 1 up to 10% IJT 22(S1):37-102,2003
Calcium sodium borosilicate 1 0.0001 to 97% IJT 32(S3): 65-72,2013
Calcium Starch Isododecenylsuccinate 1 Final report 09/2015available from CIR
Calcium Starch Octenylsuccinate 1 Final report 09/2015available from CIR
Calcium Stearate 1 up to 23% JACT 1(2):143-77,1982 confirmed
11/01 IJT22(S1):1-35, 2003
Calcium Thioglycolate 1 safe for use in hairstraighteners permanentwaves, tonics, dressings,and so forth, wave sets,other noncoloring hair
products, and hair dyes andcolors, at concentrationsup to 15.2%; hairdressersshould avoid skin contact
and minimize consumer skin
IJT 28(S3):68-133,2009
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Calcium titanium borosilicate 1 6% IJT 32(S3): 65-72,2013
Calcium Xylenesulfonate 1 not in current use * IJT 30(S3):270-283,2011
Calendula Officinalis Extract (amended) 1 concentration not reported * IJT 20(S2):13-20,2001 (original
report); IJT 29 (S4):221-243, 2010
Calendula Officinalis Flower 1 concentration not reported * IJT 20(S2):13-20,2001 (original
report); IJT 29 (S4):221-243, 2010
Calendula Officinalis Flower Extract (amended) 1 up to 6% IJT 29 (S4): 221-243,2010
Calendula Officinalis Flower Oil (amended) 1 up to 0.1% IJT 29 (S4): 221-243,2010
Calendula Officinalis Seed Oil 1 concentration not reported * IJT 20(S2):13-20,2001 (original
report); IJT 29 (S4):221-243, 2010
Camellia Japonica Seed Oil 1 0.01 to 0.2% Final report 03/11available from CIR
Camellia Kissi Seed Oil 1 0.1 - 10% Final report 03/11available from CIR
Camellia Oleifera Seed Oil 1 0.003 to 3% Final report 03/11available from CIR
Camellia Sinensis Catechins 1 not in current use * safe for use in cosmeticswhen formulated tobe non-sensitizing
Final report 09/2014available from CIR
Camellia Sinensis Flower/Leaf/Stem Juice 1 Final report 09/2014available from CIR
Camellia Sinensis Flower Extract 1 Final report 09/2014available from CIR
Camellia Sinensis Leaf 1 safe for use in cosmeticswhen formulated tobe non-sensitizing
Final report 09/2014available from CIR
Camellia Sinensis Leaf Extract 1 safe for use in cosmeticswhen formulated tobe non-sensitizing
Final report 09/2014available from CIR
Camellia Sinensis Leaf Oil 1 safe for use in cosmeticswhen formulated tobe non-sensitizing
Final report 09/2014available from CIR
Camellia Sinensis Leaf Powder 1 safe for use in cosmeticswhen formulated tobe non-sensitizing
Final report 09/2014available from CIR
Camellia Sinensis Leaf Water 1 safe for use in cosmeticswhen formulated tobe non-sensitizing
Final report 09/2014available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Camellia Sinensis Root Extract 1 Final report 09/2014available from CIR
Camellia Sinensis Seedcoat powder 1 Final report 09/2014available from CIR
Camellia Sinensis Seed extract 1 Final report 09/2014available from CIR
Camellia Sinensis Seed Oil 1 0.10% Final report 03/11available from CIR
Camellia Sinensis Seed Powder 1 Final report 09/2014available from CIR
Camellina Sativa Seed Oil 1 0.002 to 1% Final report 03/11available from CIR
Canarium Indicum Seed Oil 1 not in current use * Final report 03/11available from CIR
Candelilla Wax; now Euphorbia Cerifera (Candelilla) Wax 1 up to 27% JACT 3(3):1-41,1984 confirmed
06/03; IJT24(S1):1-102, 2005
Canolamidopropyl betaine 1 safe in cosmetics as longas they are formulatedto be non-sensitizing,
which may be based on aquantitative risk assessment
IJT 31(S1):77-111,2012
Canola Oil 1 0.0002 to 73% Final report 03/11available from CIR
Canola Oil Unsaponifiables 1 0.00% Final report 03/11available from CIR
Canola Sterols 1 Final report 12/2013available from CIR
Capramide DEA 1 safe in the present practices ofuse and concentration when
formulated to be non-irritatingand when the levels of freeDEA do not exceed those
considered safe int the CIRsafety assessment of DEAand its salts; should not beused in cosmetic products
IJT 32(S1):36-58,2013
Caprooyl phytosphingosine 1 safe as used Final report 03/2015available from CIR
Caprooyl sphingosine 1 safe as used Final report 03/2015available from CIR
Caproyl sphingosine* 1 safe as used Final report 03/2015available from CIR
Capryl/capramidopropyl betaine 1 safe in cosmetics as longas they are formulatedto be non-sensitizing,
IJT 31(S1):77-111,2012
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
which may be based on aquantitative risk assessment
Capryleth-4 1 safe in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Capryleth-5 1 safe in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Caprylic/Capric/Coco Glycerides (amended) 1 up to 4% IJT 30(S1):5S-16SCaprylic/Capric Triglyceride 1 up to 84% JEPT 4(4):105-20,
1980 confirmed06/01 IJT
22(S1):1-35, 2003Capryloyl Collagen Amino Acids 1 not in current use * safe for use in cosmetics when
formulated to be non-irritatingFinal report 12/2013
available from CIRCapryloyl Glycine 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 12/2013
available from CIRCapryloyl Gold of Pleasure Amino Acids 1 not in current use * safe for use in cosmetics when
formulated to be non-irritatingFinal report 12/2013
available from CIRCapryloyl Keratin Amino Acids 1 not in current use * safe for use in cosmetics when
formulated to be non-irritatingFinal report 12/2013
available from CIRCapryloyl Pea Amino Acids 1 not in current use * safe for use in cosmetics when
formulated to be non-irritatingFinal report 12/2013
available from CIRCapryloyl Quinoa Amino Acids 1 not in current use * safe for use in cosmetics when
formulated to be non-irritatingFinal report 12/2013
available from CIRCapryloyl Salicylic Acid 1 safe when formulated to
avoid irritation and to avoidincreasing sun sensitivity,
or when increased sunsensitivity would be expected,directions for use include thedaily use of sun protection.
IJT 22(S3):1-108,2003
Capryloyl Silk Amino Acids 1 not in current use * safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Caprylyl/capryl glucoside 1 safe in cosmetics whenformulated to be non-irritating
IJT 32 (S3): 22-48,2013
Caprylyl Butyrate 1 not in current use * safe in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Caprylyl Caprylate 1 safe in cosmeticswhen formulated
to be non- irritating
Final report 03/2013available from CIR
Caprylyl Eicosenoate 1 safe in cosmeticswhen formulated
to be non- irritating
Final report 03/2013available from CIR
Caprylyl Glucoside 1 safe in cosmeticswhen formulated
to be non- irritating
IJT 32 (S3): 22-48,2013
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Caprylyl Glyceryl Ether 1 not in current use * IJT 32 (S3): 5-21,2013
Caprylyl Glycol 1 0.00003 to 5% IJT 31 (S2): 147-168,2012
Capsaicin 1 safe in the practices of useand concentration described in
the safety assessment, whenformulated not to be irritating
IJT 26(S1):3-106,2007
Capsicum Annuum Extract 1 safe in the practices of useand concentration described in
the safety assessment, whenformulated not to be irritating
IJT 26(S1):3-106,2007
Capsicum Annuum Fruit Extract 1 safe in the practices of useand concentration described in
the safety assessment, whenformulated not to be irritating
IJT 26(S1):3-106,2007
Capsicum Annuum Fruit Powder 1 safe in the practices of useand concentration described in
the safety assessment, whenformulated not to be irritating
IJT 26(S1):3-106,2007
Capsicum Annuum Resin 1 safe in the practices of useand concentration described in
the safety assessment, whenformulated not to be irritating
IJT 26(S1):3-106,2007
Capsicum Frutescens Fruit 1 safe in the practices of useand concentration described in
the safety assessment, whenformulated not to be irritating
IJT 26(S1):3-106,2007
Capsicum Frutescens Fruit Extract 1 safe in the practices of useand concentration described in
the safety assessment, whenformulated not to be irritating
IJT 26(S1):3-106,2007
Capsicum Frutescens Resin 1 safe in the practices of useand concentration described in
the safety assessment, whenformulated not to be irritating
IJT 26(S1):3-106,2007
Captan 1 JACT 8(4):643-80,1989
Carbomer-910 1 not in current use * JACT 1(2)109-41, 1982
confirmed 11/02 IJT22(S1):1-35, 2003
Carbomer-934, -934P, -940, -941 1 up to 2% JACT 1(2)109-41,1982 confirmed
11/02 IJT22(S1):1-35, 2003
Carbomer-934P 1 up to 2% JACT 1(2)109-41,1982 confirmed
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
11/02 IJT22(S1):1-35, 2003
Carbomer-940 1 up to 2% JACT 1(2)109-41,1982 confirmed
11/02 IJT22(S1):1-35, 2003
Carbomer-941 1 up to 2% JACT 1(2)109-41,1982 confirmed
11/02 IJT22(S1):1-35, 2003
Carbomer-962 1 not in current use * JACT 1(2)109-41, 1982
confirmed 11/02 IJT22(S1):1-35, 2003
Carboxymethyl Dextran 1 not in current use * Tentative report06/12 available from
CIRCarboxymethyl Hydroxyethylcellulose 1 up to 3% Amended safety
assessment 03/09 -Available from CIR
Carboxymethyl hydroxypropyl guar 1 not in current use * IJT 34(S1): 35-65,2015
Carica Papaya Seed Oil 1 0.10% Final report 03/11available from CIR
Carnauba (Copernicia Cerifera) Wax 0 up to 20% JACT 3(3):1-41,1984 confirmed
06/03; IJT24(S1):1-102, 2005
Carnitine 1 safe when formulatedto be non- irritating
IJT 31(S3): 296-341(2012)
Carnitine HCl 1 safe when formulatedto be non- irritating
IJT 31(S3): 296-341(2012)
Carnitine hydroxycitrate 1 safe when formulatedto be non- irritating
IJT 31(S3): 296-341(2012)
Carnitine PCA 1 safe when formulatedto be non- irritating
IJT 31(S3): 296-341(2012)
Carrageenan 1 Final report 09/2015available from CIR
Carthamus Tinctorius (Safflower) Seed Oil 1 up to 84% in 2004 JACT 4(5):171-97,1985 confirmed
02/04; IJT25(S2) :1-89,2006;Final report 03/11
available from CIRCarvacrol 1 up to 0.5% IJT 25(S1):29-127,
2006Carya Illinoensis (Pecan) Seed Oil 1 not in current use * Final report 03/11
available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Caryocar Brasiliense Fruit Oil 1 0.0005 to 0.2% Final report 03/11available from CIR
Cassia Angustifolia Seed Polysaccharide 1 Final report 09/2015available from CIR
Cassia Gum 1 not in current use * IJT 34 (S1): 35-65,2015
Cassia hydroxypropyltrimonium chloride 1 0.06 to 0.4% in rinse-off IJT 34 (S1): 35-65,2015
Castor oil phosphate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2014available from CIR
Cellobiose octanonanoate 1 not in current use * IJT 30(S3):228-269,2011
Cellulose (amended) 1 up to 88% Amended safetyassessment 03/09 -
Available from CIRCellulose Acetate (amended) 1 up to 2% Amended safety
assessment 03/09 -Available from CIR
Cellulose Acetate Butyrate (amended) 1 up to 17% Amended safetyassessment 03/09 -
Available from CIRCellulose Acetate Propionate 1 not in use at the time* Amended safety
assessment 03/09 -Available from CIR
Cellulose Gum (amended) 1 up to 20% Amended safetyassessment 03/09 -
Available from CIRJACT 5(3):1-59,
1986 (original report)Cellulose Succinate 1 not in use at the time* Amended safety
assessment 03/09 -Available from CIR
Centella asiatica callus culture 1 safe as used when formulatedto be non-sensitizing
Final report 06/2015available from CIR
Centella asiatica extract 1 safe as used when formulatedto be non-sensitizing
Final report 06/2015available from CIR
Centella asiatica flower/leaf/stem extract 1 safe as used when formulatedto be non-sensitizing
Final report 06/2015available from CIR
Centella asiatica leaf cell culture extract 1 safe as used when formulatedto be non-sensitizing
Final report 06/2015available from CIR
Centella asiatica leaf extract 1 safe as used when formulatedto be non-sensitizing
Final report 06/2015available from CIR
Centella asiatica leaf water 1 safe as used when formulatedto be non-sensitizing
Final report 06/2015available from CIR
Centella asiatica meristem cell culture 1 safe as used when formulatedto be non-sensitizing
Final report 06/2015available from CIR
Centella asiatica meristem cell culture extract 1 safe as used when formulatedto be non-sensitizing
Final report 06/2015available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Centella asiatica root extract 1 safe as used when formulatedto be non-sensitizing
Final report 06/2015available from CIR
Ceramide 1 [retired] 1 safe as used Final report 03/2015available from CIR
Ceramide 1A [retired] 1 safe as used Final report 03/2015available from CIR
Ceramide 2 [retired] 1 safe as used Final report 03/2015available from CIR
Ceramide 3 [retired] 1 safe as used Final report 03/2015available from CIR
Ceramide 4* [retired] 1 safe as used Final report 03/2015available from CIR
Ceramide 5 [retired] 1 safe as used Final report 03/2015available from CIR
Ceramide 6 II [retired] 1 safe as used Final report 03/2015available from CIR
Ceramide AP 1 safe as used Final report 03/2015available from CIR
Ceramide AS 1 safe as used Final report 03/2015available from CIR
Ceramide EOP 1 safe as used Final report 03/2015available from CIR
Ceramide EOS 1 safe as used Final report 03/2015available from CIR
Ceramide NG* 1 safe as used Final report 03/2015available from CIR
Ceramide NP 1 safe as used Final report 03/2015available from CIR
Ceramide NS 1 safe as used Final report 03/2015available from CIR
Ceramide NS dilaurate* 1 safe as used Final report 03/2015available from CIR
Ceratonia siliqua gum 1 0.0003 to 0.07% IJT 34(S1): 35-65,2015
Ceresin 1 up to 20% JACT 3(3):43-99,1984 confirmed
06/03 IJT24(S1):67-74, 2005
Ceteareth-10 1 Safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S3):41-49,1999; IJT
31(S2):169-244(2012)
Ceteareth-100 1 Safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S3):41-49,1999; IJT
31(S2):169-244(2012)
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Ceteareth-11 1 Safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S3):41-49,1999; IJT
31(S2):169-244(2012)
Ceteareth-12 1 Safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S3):41-49,1999; IJT
31(S2):169-244(2012)
Ceteareth-13 1 Safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S3):41-49,1999; IJT
31(S2):169-244(2012)
Ceteareth-14 1 Safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S3):41-49,1999; IJT
31(S2):169-244(2012)
Ceteareth-15 1 Safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S3):41-49,1999; IJT
31(S2):169-244(2012)
Ceteareth-16 1 Safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S3):41-49,1999; IJT
31(S2):169-244(2012)
Ceteareth-17 1 Safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S3):41-49,1999; IJT
31(S2):169-244(2012)
Ceteareth-18 1 Safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S3):41-49,1999; IJT
31(S2):169-244(2012)
Ceteareth-2 1 Safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S3):41-49,1999; IJT
31(S2):169-244(2012)
Ceteareth-20 1 Safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S3):41-49,1999; IJT
31(S2):169-244(2012)
Ceteareth-23 1 Safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S3):41-49,1999; IJT
31(S2):169-244(2012)
Ceteareth-24 1 Safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S3):41-49,1999; IJT
31(S2):169-244(2012)
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Ceteareth-25 1 Safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S3):41-49,1999; IJT
31(S2):169-244(2012)
Ceteareth-27 1 Safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S3):41-49,1999; IJT
31(S2):169-244(2012)
Ceteareth-28 1 Safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S3):41-49,1999; IJT
31(S2):169-244(2012)
Ceteareth-29 1 Safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S3):41-49,1999; IJT
31(S2):169-244(2012)
Ceteareth-3 1 Safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S3):41-49,1999; IJT
31(S2):169-244(2012)
Ceteareth-30 1 Safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S3):41-49,1999; IJT
31(S2):169-244(2012)
Ceteareth-33 1 Safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S3):41-49,1999; IJT
31(S2):169-244(2012)
Ceteareth-34 1 Safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S3):41-49,1999; IJT
31(S2):169-244(2012)
Ceteareth-4 1 Safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S3):41-49,1999; IJT
31(S2):169-244(2012)
Ceteareth-40 1 Safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S3):41-49,1999; IJT
31(S2):169-244(2012)
Ceteareth-5 1 Safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S3):41-49,1999; IJT
31(S2):169-244(2012)
Ceteareth-50 1 Safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S3):41-49,1999; IJT
31(S2):169-244(2012)
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Ceteareth-55 1 Safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S3):41-49,1999; IJT
31(S2):169-244(2012)
Ceteareth-6 1 Safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S3):41-49,1999; IJT
31(S2):169-244(2012)
Ceteareth-60 1 Safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S3):41-49,1999; IJT
31(S2):169-244(2012)
Ceteareth-7 1 Safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S3):41-49,1999; IJT
31(S2):169-244(2012)
Ceteareth-8 1 Safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S3):41-49,1999; IJT
31(S2):169-244(2012)
Ceteareth-80 1 Safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S3):41-49,1999; IJT
31(S2):169-244(2012)
Ceteareth-9 1 Safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S3):41-49,1999; IJT
31(S2):169-244(2012)
Ceteartrimonium chloride 1 safe in the present practices ofuse and concentration, when
formulated to be non-irritating
IJT 31(S3): 296-341(2012)
Cetearyl Alcohol 1 up to 25% JACT 7(3):359-413,1988 confirmed
12/05Cetearyl Behenate 1 not in current use * safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIRCetearyl Candelillate Final report 03/2013
available from CIRCetearyl dimethicone/vinyl dimethicone crosspolymer 1 0.001 to 0.005% IJT 33 (S2): 65-115,
2014Cetearyl dimethicone crosspolymer 1 00.002 to 23% IJT 33 (S2): 65-115,
2014Cetearyl ethylhexanoate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIRCetearyl glucoside 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 32 (S3): 22-48,
2013Cetearyl Isononanoate 1 up to 50% safe for use in cosmetics when
formulated to be non-irritatingIJT 30(S3):228-269,
2011; Final Report
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
03/2013 availablefrom CIR
Cetearyl Methicone 1 up to 1% IJT 22(S2):11-35,2003
Cetearyl Nonanoate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
IJT 30(S3):228-269,2011; Final Report03/2013 available
from CIRCetearyl Octanoate (aka Cetearyl Ethylhexanoate) 1 up to 25% JACT 1(4):81-92,
1982 confirmed06/03 IJT 25(S2),
2006Cetearyl Olivate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal Report 03/2013
available from CIRCetearyl Palmate 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal Report 03/2013
available from CIRCetearyl Palmitate 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal Report 03/2013
available from CIRCetearyl Phosphate 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 09/2014
available from CIRCetearyl Rice Branate 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal Report 03/2013
available from CIRCetearyl Stearate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal Report 03/2013
available from CIRCeteth-1 1 safe for use in cosmetics
when formulatedto be non- irritating
IJT 31(Suppl.2):169-244, 2012;
IJT 18(2):1-8, 1999(original report)
Ceteth-10 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(Suppl.2):169-244, 2012;
IJT 18(2):1-8, 1999(original report)
Ceteth-12 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(Suppl.2):169-244, 2012;
IJT 18(2):1-8, 1999(original report)
Ceteth-13 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(Suppl.2):169-244, 2012;
IJT 18(2):1-8, 1999(original report)
Ceteth-14 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(Suppl.2):169-244, 2012;
IJT 18(2):1-8, 1999(original report)
Ceteth-15 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(Suppl.2):169-244, 2012;
IJT 18(2):1-8, 1999(original report)
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Ceteth-150 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(Suppl.2):169-244, 2012;
IJT 18(2):1-8, 1999(original report)
Ceteth-16 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(Suppl.2):169-244, 2012;
IJT 18(2):1-8, 1999(original report)
Ceteth-17 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(Suppl.2):169-244, 2012;
IJT 18(2):1-8, 1999(original report)
Ceteth-18 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(Suppl.2):169-244, 2012;
IJT 18(2):1-8, 1999(original report)
Ceteth-2 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(Suppl.2):169-244, 2012;
IJT 18(2):1-8, 1999(original report)
Ceteth-20 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(Suppl.2):169-244, 2012;
IJT 18(2):1-8, 1999(original report)
Ceteth-23 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(Suppl.2):169-244, 2012;
IJT 18(2):1-8, 1999(original report)
Ceteth-24 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(Suppl.2):169-244, 2012;
IJT 18(2):1-8, 1999(original report)
Ceteth-25 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(Suppl.2):169-244, 2012;
IJT 18(2):1-8, 1999(original report)
Ceteth-3 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(Suppl.2):169-244, 2012;
IJT 18(2):1-8, 1999(original report)
Ceteth-30 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(Suppl.2):169-244, 2012;
IJT 18(2):1-8, 1999(original report)
Ceteth-4 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(Suppl.2):169-244, 2012;
IJT 18(2):1-8, 1999(original report)
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Ceteth-40 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(Suppl.2):169-244, 2012;
IJT 18(2):1-8, 1999(original report)
Ceteth-45 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(Suppl.2):169-244, 2012;
IJT 18(2):1-8, 1999(original report)
Ceteth-5 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(Suppl.2):169-244, 2012;
IJT 18(2):1-8, 1999(original report)
Ceteth-6 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(Suppl.2):169-244, 2012;
IJT 18(2):1-8, 1999(original report)
Ceteth-7 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(Suppl.2):169-244, 2012;
IJT 18(2):1-8, 1999(original report)
Cetethyl Morpholinium Ethosulfate 1 IJT 20(S3):99 -102,2001
Cetoleth-10 1 safe as used when formulatedto be non- irritating
IJT 31(Suppl.2):169-244, 2012
Cetoleth-11 1 safe as used when formulatedto be non- irritating
IJT 31(Suppl.2):169-244, 2012
Cetoleth-15 1 safe as used when formulatedto be non- irritating
IJT 31(Suppl.2):169-244, 2012
Cetoleth-18 1 safe as used when formulatedto be non- irritating
IJT 31(Suppl.2):169-244, 2012
Cetoleth-2 1 safe as used when formulatedto be non- irritating
IJT 31(Suppl.2):169-244, 2012
Cetoleth-20 1 safe as used when formulatedto be non- irritating
IJT 31(Suppl.2):169-244, 2012
Cetoleth-22 1 safe as used when formulatedto be non- irritating
IJT 31(Suppl.2):169-244, 2012
Cetoleth-24 1 safe as used when formulatedto be non- irritating
IJT 31(Suppl.2):169-244, 2012
Cetoleth-25 1 safe as used when formulatedto be non- irritating
IJT 31(Suppl.2):169-244, 2012
Cetoleth-30 1 safe as used when formulatedto be non- irritating
IJT 31(Suppl.2):169-244, 2012
Cetoleth-4 1 safe as used when formulatedto be non- irritating
IJT 31(Suppl.2):169-244, 2012
Cetoleth-5 1 safe as used when formulatedto be non- irritating
IJT 31(Suppl.2):169-244, 2012
Cetoleth-6 1 safe as used when formulatedto be non- irritating
IJT 31(Suppl.2):169-244, 2012
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Cetrimonium Bromide 1 safe as used when formulatedto be non- irritating
IJT16(S3):195-220,1997
(original report);IJT 31(S3): 296-341
(2012)Cetrimonium Chloride 1 safe as used when formulated
to be non- irritatingIJT
16(S3):195-220,1997(original report);
IJT 31(S3): 296-341(2012)
Cetrimonium methosulfate 1 safe as used when formulatedto be non- irritating
IJT 31(S3): 296-341(2012)
Cetyl Acetate 1 0.01 to 17% IJT 31(S1):112-136,2012
Cetyl Alcohol 1 up to 50% JACT 7(3):359-413,1988 confirmed
12/05Cetyl Babassuate 1 Safe as used in cosmetics
when formulatedto be non-irritating
Final Report 03/2013available from CIR
Cetyl Behenate 1 not in current use* Safe as used in cosmeticswhen formulated
to be non-irritating
Final Report 03/2013available from CIR
Cetyl Betaine 1 0.36 to 7.4% Safe as used in cosmeticswhen formulated
to be non-irritating
Final report 03/2014available from CIR
Cetyl Caprate 1 Safe as used in cosmeticswhen formulated
to be non- irritating
Final Report 03/2013available from CIR
Cetyl Caprylate 1 Safe as used in cosmeticswhen formulated
to be non-irritating
Safe as used incosmetics when
formulated to be non-irritating
Cetyl Dimethicone 1 up to 10% IJT 22(S2):11-35,2003
Cetyl dimethicone/bis-vinyldimethicone crosspolymer 1 0.001 to 0.005% IJT 33 (S2): 65-115,2014
Cetyl Dimethyloctanoate 1 not in current use* Safe as used in cosmeticswhen formulated
to be non-irritating
Safe as used incosmetics when
formulated to be non-irritating
Cetyl Esters 1 up to 7% Safe as used in cosmeticswhen formulated
to be non-irritating
IJT16(S1):123-30,1997;final report 03/2013available from CIR
Cetyl ethylhexanoate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Cetyl Glyceryl Ether/ Chimyl Alcohol 1 IJT 32 (S3): 5-21,2013
Cetyl Glycol 1 not in use at the time* IJT 31 (S2): 147-168,2012
Cetyl hexacosyl dimethicone/bis-vinyldimethiconecrosspolymer
1 not in current use* IJT 33 (S2): 65-115,2014
Cetyl Hydroxyethylcellulose (amended) 1 up to 2% Amended safetyassessment 03/09 -
Available from CIRCetyl isononanoate 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingIJT 30(S3):228-269,
2011; Final Report03/2013 available
from CIRCetyl Lactate (Amended) 1 safe for use in cosmetic
products at concentrationsless than or equal to10%,at final formulation pH
greater than or equal to3.5,when formulated to avoidincreasing sun sensitivityor when directions for use
include the daily use of sunprotection. These ingredients
are safe for use in sal
IJT 17(S1):1-242,1998 JACT
1(2):97-107, 1982(Original Report)
Cetyl Laurate 1 safe for use in cosmeticswhen formulated
to be non- irritating
Final Report 03/2013available from CIR
Cetyl Myristate 1 up to 6% safe for use in cosmetics whenformulated to be non-irritating
IJT29(S3) :162-186,2010;
final report 03/2013available from CIR
Cetyl Myristoleate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final Report 03/2013available from CIR
Cetyl Oleate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final Report 03/2013available from CIR
Cetyl Palmitate 1 up to 11% safe for use in cosmetics whenformulated to be non-irritating
JACT 1(2):13-35,1982 confirmed
09/01 IJT24(S1):28-32, 2005;final report 03/2013available from CIR
Cetyl PEG/PPG-10/1 Dimethicone 1 Final report 12/2014available from CIR
Cetyl PEG/PPG-15/15 Butyl Ether Dimethicone* 1 Final report 12/2014available from CIR
Cetyl PEG/PPG-7/3 Dimethicone* 1 Final report 12/2014available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Cetyl PEG-8 Dimethicone* 1 Final report 12/2014available from CIR
Cetyl Phosphate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2014available from CIR
Cetyl Ricinoleate 1 up to 10% safe for use in cosmetics whenformulated to be non-irritating
IJT 26(S3): 31-77,2007; final report03/2013 available
from CIRCetyl Stearate 1 up to 15% safe for use in cosmetics when
formulated to be non-irritatingJACT 4(5):107-46,
1985 confirmed06/03 IJT
24(S1):21-25, 2005;final report 03/2013available from CIR
Cetyl Tallowate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Chamomilla recutita (matricaria) extract 1 Final report 12/2013available from CIR
Chamomilla recutita (matricaria) flower 1 safe for use in cosmeticswhen formulated tobe non-sensitizing
Final report 12/2013available from CIR
Chamomilla recutita (matricaria) flower/leaf/stem extract 1 Final report 12/2013available from CIR
Chamomilla recutita (matricaria) flower/leaf/stem water 1 Final report 12/2013available from CIR
Chamomilla recutita (matricaria) flower/leaf extract 1 Final report 12/2013available from CIR
Chamomilla recutita (matricaria) flower extract 1 safe for use in cosmeticswhen formulated tobe non-sensitizing
Final report 12/2013available from CIR
Chamomilla recutita (matricaria) flower oil 1 safe for use in cosmeticswhen formulated tobe non-sensitizing
Final report 12/2013available from CIR
Chamomilla recutita (matricaria) flower powder 1 safe for use in cosmeticswhen formulated tobe non-sensitizing
Final report 12/2013available from CIR
Chamomilla recutita (matricaria) flower water 1 safe for use in cosmeticswhen formulated tobe non-sensitizing
Final report 12/2013available from CIR
Chamomilla recutita (matricaria) leaf extract 1 Final report 12/2013available from CIR
Chamomilla recutita (matricaria) oil 1 Final report 12/2013available from CIR
Chenopodium Quinoa Seed Oil 1 0.30% Final report 03/11available from CIR
Chimyl Isostearate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Chimyl Stearate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Chlorhexidine 1 up to .14% JACT 12(3):201-23,1993 IJT 18(2):69,
1999 (Note)Chlorhexidine Diacetate 1 up to .19% JACT 12 (3):201-23,
1993 IJT 18(2):69,1999 (Note)
Chlorhexidine Digluconate 1 up to .20% JACT 12 (3):201-23,1993 IJT 18(2):69,
1999 (Note)Chlorhexidine Dihydrochloride 1 up to .16% JACT 12(3):201-23,
1993 IJT 18(2):69,1999 (Note)
Chloroacetamide 1 sensitization JACT 10(1):21- 32,1991
Chlorophene 1 IJT 23(S1):1-27 2004Chlorothymol (amended) 1 up to 0.5% IJT 25 (S1):29-127,
2006Chloroxylenol 1 up to 0.5% JACT 4(5):147-69,
1985 confirmed02/04 IJT 25(S2),
2006Chlorphenesin 1 0.000008 to 0.32% IJT 33 (2): 5-15,
2014Cholesterol 1 up to 3% JACT 5(5):491-516,
1986 confirmed12/04IJT 25(S2), 2006
Cholesteryl Nonanoate 1 up to 30% IJT 30 (S3):228-269,2011
Choleth-24 1 up to 1.3% JACT 1(4):119-26,1982 confirmed
06/02 IJT24(S1):32-34, 2005
Choline chloride 1 safe when formulatedto be non- irritating
IJT 31(S3): 296-341(2012)
Cichorium Intybus (Chicory) Root Oligosaccharides 1 Final report 09/2015available from CIR
Citric acid 1 0.0000005 to 39% IJT 33 (S2): 16 -46,2014
Citrullus Lanatus (Watermelon) Seed Oil 1 2% Final report 03/11available from CIR
Citrus Aurantifolia (Lime)/Citrus Limon (Lemon) FruitWater
1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain more
Final report 12/2015available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
than 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Citrus Aurantifolia (lime) Fruit 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Aurantifolia (lime) Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Aurantifolia (lime) Fruit Water 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Aurantifolia (lime) Juice 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Aurantifolia (Lime) Seed Oil 1 not in current use* safe for use in cosmeticproducts when finished
products, excluding rinse-off products, do not contain
more than 0.0015% (15ppm) 5-methyoxypsoralen
(5-MOP), and whenformulated to be non-
sensitizing and non-irritating.
Final report 03/11available from CIR;Final report 09/2014
available from CIR
Citrus Aurantifolia (Lime) Seed Oil Unsaponifiables 1 not in current use* Final report 03/11available from CIR
Citrus Aurantium Amara (Bitter Orange) Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
Final report 12/2015available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Citrus Aurantium Amara (Bitter Orange) Fruit Juice Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Aurantium Amara (Bitter orange) Peel Oil 1 safe for use in cosmeticproducts when finished
products, excluding rinse-off products, do not contain
more than 0.0015% (15ppm) 5-methyoxypsoralen
(5-MOP), and whenformulated to be non-
sensitizing and non-irritating.
Final report 09/2014available from CIR
Citrus Aurantium Bergamia (Bergamot) Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Aurantium Bergamia (Bergamot) Fruit Water 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Aurantium Currassuviensis Peel Oil 1 not in current use* safe for use in cosmeticproducts when finished
products, excluding rinse-off products, do not contain
more than 0.0015% (15ppm) 5-methyoxypsoralen
(5-MOP), and whenformulated to be non-
sensitizing and non-irritating.
Final report 09/2014available from CIR
Citrus Aurantium Dulcis (orange) Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-
Final report 12/2015available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
sensitizing and non-irritating,provided that leave-on
products do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Citrus Aurantium Dulcis (orange) Fruit Powder 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Aurantium Dulcis (orange) Fruit Water 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Aurantium Dulcis (orange) Juice 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Aurantium Dulcis (Orange) Peel Oil 1 safe for use in cosmeticproducts when finished
products, excluding rinse-off products, do not contain
more than 0.0015% (15ppm) 5-methyoxypsoralen
(5-MOP), and whenformulated to be non-
sensitizing and non-irritating.
Final report 09/2014available from CIR
Citrus Aurantium Dulcis (Orange) Seed Oil 1 not in current use* Final report 03/11available from CIR
Citrus Aurantium Dulcis (Orange) Seed Oil Unsaponifiables 1 not in current use* Final report 03/11available from CIR
Citrus Aurantium Sinensis (orange) Fiber 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain more
Final report 12/2015available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
than 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Citrus Clementina Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Clementina Juice 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Clementina peel oil 1 not in current use* safe for use in cosmeticproducts when finished
products, excluding rinse-off products, do not contain
more than 0.0015% (15ppm) 5-methyoxypsoralen
(5-MOP), and whenformulated to be non-
sensitizing and non-irritating.
Final report 09/2014available from CIR
Citrus Depressa Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Depressa Fruit Water 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Glauca Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain more
Final report 12/2015available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
than 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Citrus Grandis/Paradisi Fruit Water 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Grandis (grapefruit) Fruit/peel Water 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Grandis (grapefruit) Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Grandis (grapefruit) Fruit Water 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Grandis (grapefruit) Juice 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Grandis (Grapefruit) Peel Oil 1 safe for use in cosmeticproducts when finished
products, excluding rinse-off products, do not contain
more than 0.0015% (15ppm) 5-methyoxypsoralen
(5-MOP), and when
Final report 09/2014available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
formulated to be non-sensitizing and non-irritating.
Citrus Grandis (Grapefruit) Seed Oil 1 not in current use* Final report 03/11available from CIR
Citrus Grandis (Grapefruit) Seed Oil Unsaponifiables 1 not in current use* Final report 03/11available from CIR
Citrus Hassaku/natsudaidai Fruit Juice 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Hassaku/natsudaidai Fruit Powder 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Hassaku Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Iyo Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Iyo Fruit Water 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Iyo Peel Oil 1 not in current use* safe for use in cosmeticproducts when finished
products, excluding rinse-
Final report 09/2014available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
off products, do not containmore than 0.0015% (15
ppm) 5-methyoxypsoralen(5-MOP), and when
formulated to be non-sensitizing and non-irritating.
Citrus Jabara Juice 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Japonica Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Junos Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Junos Fruit Juice 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Junos Fruit Oil 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Junos Fruit Powder 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-
Final report 12/2015available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
sensitizing and non-irritating,provided that leave-on
products do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Citrus Junos Fruit Water 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Junos Peel Oil 1 safe for use in cosmeticproducts when finished
products, excluding rinse-off products, do not contain
more than 0.0015% (15ppm) 5-methyoxypsoralen
(5-MOP), and whenformulated to be non-
sensitizing and non-irritating.
Final report 09/2014available from CIR
Citrus Limon (lemon) Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Limon (lemon) Fruit Oil 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Limon (lemon) Fruit Powder 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Limon (lemon) Fruit Water 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-
Final report 12/2015available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
sensitizing and non-irritating,provided that leave-on
products do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Citrus Limon (lemon) Juice 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Limon (lemon) Juice Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Limon (lemon) Juice Powder 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Limon (Lemon) Peel Oil 1 safe for use in cosmeticproducts when finished
products, excluding rinse-off products, do not contain
more than 0.0015% (15ppm) 5-methyoxypsoralen
(5-MOP), and whenformulated to be non-
sensitizing and non-irritating.
Final report 09/2014available from CIR
Citrus Limon (Lemon) Seed Oil 1 6% Final report 03/11available from CIR
Citrus Madurensis Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Citrus Madurensis Fruit Juice 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Medica Vulgaris Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Medica Vulgaris Peel Oil 1 safe for use in cosmeticproducts when finished
products, excluding rinse-off products, do not contain
more than 0.0015% (15ppm) 5-methyoxypsoralen
(5-MOP), and whenformulated to be non-
sensitizing and non-irritating.
Final report 09/2014available from CIR
Citrus Nobilis (mandarin Orange) Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Nobilis (mandarin Orange) Fruit Juice 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Nobilis (Mandarin Orange) Peel Oil 1 safe for use in cosmeticproducts when finished
products, excluding rinse-off products, do not contain
more than 0.0015% (15ppm) 5-methyoxypsoralen
(5-MOP), and when
Final report 09/2014available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
formulated to be non-sensitizing and non-irritating.
Citrus Paradisi (grapefruit) Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Paradisi (grapefruit) Fruit Water 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Paradisi (grapefruit) Juice 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Paradisi (Grapefruit) Seed Oil 1 0.01 to 20% Final report 03/11available from CIR
Citrus Reticulata (tangerine) Fruit 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Reticulata (tangerine) Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Reticulata (tangerine) Fruit Water 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-on
Final report 12/2015available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
products do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Citrus Reticulata (Tangerine) Peel Oil 1 safe for use in cosmeticproducts when finished
products, excluding rinse-off products, do not contain
more than 0.0015% (15ppm) 5-methyoxypsoralen
(5-MOP), and whenformulated to be non-
sensitizing and non-irritating.
Final report 09/2014available from CIR
Citrus Shunkokan Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Sinensis (orange) Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Sinensis (orange) Fruit Water 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Sphaerocarpa Fruit Juice 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Sudachi Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-on
Final report 12/2015available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
products do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Citrus Sudachi Fruit Juice 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Tachibana/reticulata Fruit Juice 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Tachibana/Reticulata Peel Oil 1 safe for use in cosmeticproducts when finished
products, excluding rinse-off products, do not contain
more than 0.0015% (15ppm) 5-methyoxypsoralen
(5-MOP), and whenformulated to be non-
sensitizing and non-irritating.
Final report 09/2014available from CIR
Citrus Tamurana Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Tangelo Fruit Juice 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Tangelo Fruit Powder 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-on
Final report 12/2015available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
products do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Citrus Tangerina (tangerine) Fruit 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Tangerina (tangerine) Fruit Water 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Tangerina (Tangerine) Peel Oil 1 safe for use in cosmeticproducts when finished
products, excluding rinse-off products, do not contain
more than 0.0015% (15ppm) 5-methyoxypsoralen
(5-MOP), and whenformulated to be non-
sensitizing and non-irritating.
Final report 09/2014available from CIR
Citrus Tankan Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Tankan Fruit Water 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Unshiu/citrus Reticulata/citrus Iyo Fruit Water 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-on
Final report 12/2015available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
products do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Citrus Unshiu/sinensis/reticulata Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Unshiu Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Unshiu Fruit Juice 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Unshiu Fruit Juice Ferment Extract Filtrate 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Unshiu Fruit Oil 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Unshiu Fruit Powder 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain more
Final report 12/2015available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
than 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Citrus Unshiu Fruit Water 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Coal Tar 1 IJT 27(S2):1-24,2008
Cocamide DEA (Amended) 1 safe in the present practices ofuse and concentration when
formulated to be non-irritatingand when the levels of freeDEA do not exceed those
considered safe int the CIRsafety assessment of DEAand its salts; should not beused in cosmetic product
IJT 32(S1):36-58,2013
Cocamide MEA (amended) 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
IJT 34(S1): 18-34,2015; IJT 18(2):9-16,1999 (original report)
Cocamide methyl MEA 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
IJT 34(S1): 18-34,2015; IJT 18(2):9-16,1999 (original report)
Cocamidopropylamine Oxide 1 safe for use in rinse-offs(up to 4%); insufficient
data for leave-ons
IJT 27(S1): 55-62,2008 IJT 19(2):1-5,
2000 (original report)Cocamidopropyl betainamide MEA chloride 1 safe in the present practices
of use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
IJT 34(S1): 18-34,2015
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Cocamidopropyl Betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
JACT 10(1):33-52,1991; IJT
31(S1):77-111, 2012
Cocamidopropyl dimethylamine 1 safe in cosmetics as longas they are formulatedto be non-sensitizing,
which may be based on aquantitative risk assessment
Final report 06/2014available from CIR
Coceth-10 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Coceth-20 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Coceth-25 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Coceth-3 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Coceth-5 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Coceth-6 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Coceth-7 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Coceth-8 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Coco/oleamidopropyl betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
JACT 10(1):33-52,1991; IJT
31(S1):77-111, 2012
Coco/sunfloweramidopropyl betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
JACT 10(1):33-52,1991; IJT
31(S1):77-111, 2012
Cocoamphoacetate 1 up to 6% JACT 9(2):121-42,1990 confirmed
04/06
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Cocoamphodiacetate 1 up to 12% JACT 9(2):121-42, 1990 confirmed
04/06Cocoamphodipropionate 1 up to 15% JACT 9 (2):121-42,
1990 confirmed04/06
Cocoamphopropionate 1 up to 10% JACT 9(2):121-42, 1990 confirmed
04/06Coco-betaine 1 0.53 to 9.8% safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2014
available from CIRCoco-Caprylate 1 safe for use in cosmetics
when formulatedto be non- irritating
Final report 03/2013available from CIR
Coco-Caprylate/Caprate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Coco-glucoside 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 32 (S3): 22-48,2013
Cocoglycerides (amended) 1 up to 14% IJT 30 (S1):5S-16SCoconut Acid (amended) 1 up to 14% in 2011 JACT 5(3):103-21,
1986 (originalreport); IJT 30 (s1):
5s-16s, 2011; alsoincluded in the Plant
Derived Fatty AcidOils report 03/11
Coconut Alcohol (amended) 1 up to 0.9% IJT 30 (S1):5S-16S,2011
Coconut Oil Decyl Esters (amended) 1 not in current use1 IJT 30(S1):5S-16S,2011
Coconut Oil PEG-10 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Coco-Rapeseedate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Cocos Nucifera (Coconut) Oil (amended) 1 up to 80% in 2011 JACT 5(3):103-21,1986 (original
report); IJT 30 (s1):5s-16s, 2011; also
included in the PlantDerived Fatty Acid
Oils report 03/11Cocos Nucifera (Coconut) Seed Butter 1 not in current use* Final report 03/11
available from CIRCocotrimonium chloride 1 safe when formulated
to be non- irritatingIJT 31(S3): 296-341
(2012)Cocotrimonium methosulfate 1 safe when formulated
to be non- irritatingIJT 31(S3): 296-341
(2012)
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Cocoylcholine methosulfate 1 safe when formulatedto be non- irritating
IJT 31(S3): 296-341(2012)
Cocoyl glutamic acid 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Cocoyl Sarcosine 1 safe as used in rinse-offproducts; but 5% in leave-on products. Should not beused in products where N-nitroso compounds may beformed. Insufficient data todetermine safety in products
where these ingredientsare likely to be inhaled.
IJT 20(S1):1-14,2001
Coix Lacryma-Jobi (Job's Tears) Seed Oil 1 not in current use* Final report 03/11available from CIR
Collagen Amino Acids 1 IJT 33(S4):5-12,2014
Collodion 1 Final report 06/13available from CIR
Copernicia Cerifera (Carnauba) Wax 1 up to 20% JACT 3(3):1-41,1984 confirmed
06/03 IJT24(S1):48-52, 2005
Copper citrate 1 not in current use* IJT 33 (S2): 16-46,2014
Copper tripeptide-1 1 Final report 06/2014available from CIR
Corn Acid 1 not in current use* IJT 30(S1):17- 39,2011; final report
03/11 available fromCIR
Cornamide/cocamide DEA 1 safe in the present practices ofuse and concentration when
formulated to be non-irritatingand when the levels of freeDEA do not exceed those
considered safe int the CIRsafety assessment of DEAand its salts; should not beused in cosmetic products
IJT 32(S1):36-58,2013
Cornamide DEA 1 safe in the present practices ofuse and concentration when
formulated to be non-irritatingand when the levels of freeDEA do not exceed those
considered safe int the CIRsafety assessment of DEA
IJT 32(S1):36-58,2013
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
and its salts; should not beused in cosmetic products
Corn Gluten Amino Acids 1 not in current use* IJT 33(S4):5-12,2014
Corn Glycerides 1 not in current use* Final Report 09/08available from CIR
Corn Oil PEG-6 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Corn Oil PEG-8 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Corn Starch Modified 1 Final report 09/2015available from CIR
Corylus Americana (Hazelnut) Leaf Extract 1 IJT 20(S1):15-20,2001
Corylus Americana (Hazelnut) Seed Extract 1 IJT 20(S1):15-20,2001
Corylus Americana (Hazelnut) Seed Oil 1 IJT 20(S1):15-20,2001; Final report
03/11 available fromCIR
Corylus Avellana (Hazelnut) Leaf Extract 1 IJT 20(S1):15-20,2001
Corylus Avellana (Hazelnut) Seed Extract 1 IJT 20(S1):15-20,2001
Corylus Avellana (Hazelnut) Seed Oil 1 0.005 to 98% IJT 20(S1):15-20,2001; Final report
03/11 available fromCIR
Corylus Rostrata (Hazelnut) Leaf Extract 1 IJT 20(S1):15-20,2001
Corylus Rostrata (Hazelnut) Seed Extract 1 IJT 20(S1):15-20,2001
Cottonseed Acid 1 not in current use* IJT 20 (S2):21-29,2001; Final amended
report 03/11 availablefrom CIR
Cottonseed Glyceride 1 safe as used in cosmeticproducts, provided that
established and imposed limitson gossypol, heavy metals,
and pesticide concentrationsare not exceeded
IJT 20(S2):21-29,2001
Crambe Abyssinica Seed Oil 1 concentration not reported* Final report 03/11available from CIR
Crotonic acid/vinyl C8-12 isoalkyl esters/VA/bis-vinyldimethicone crosspolymer
1 not in current use* IJT 33 (S2): 65-115,2014
Cucumis Sativus (Cucumber) Extract 1 0.0002 to 0.003% IJT 33 (2): 47-64,2014
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Cucumis Sativus (Cucumber) Fruit 1 concentration not reported* IJT 33 (2): 47-64,2014
Cucumis Sativus (Cucumber) Fruit Extract 1 0.0000001 to 1% IJT 33 (2): 47-64,2014
Cucumis Sativus (Cucumber) Fruit Water 1 0.05 to 3% IJT 33 (2): 47-64,2014
Cucumis Sativus (Cucumber) Juice 1 concentration not reported* IJT 33 (2): 47-64,2014
Cucumis Sativus (Cucumber) Seed Extract 1 0.01 to 0.08% IJT 33 (2): 47-64,2014
Cucumis Sativus (Cucumber) Seed Oil 1 concentration not reported* Final report 03/2011available from CIR
Cucurbita Pepo (Pumpkin) Seed Oil 1 0.003 to 0.1% Final report 03/2011available from CIR
Cupuassauamidopropyl betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
IJT 31(S1):77-111,2012
Cyamopsis tetragonoloba (guar) gum 1 0.02 to 1% in leave-on;0.09 to 5% in rinse-off
IJT 34 (S1): 35-65,2015
Cyclodextrin 1 Final report 09/2015available from CIR
Cyclodextrin Hydroxypropyltrimonium Chloride 1 Final report 09/2015available from CIR
Cyclodextrin Laurate 1 Final report 09/2015available from CIR
Cycloheptasiloxane (amended) 1 not reported * IJT 30(S3):149-227,2011
Cyclohexasiloxane(amended) 1 up to 48% IJT 30 (S3):149-227,2011
Cyclohexyl Methacrylate 1 safe in nail enhancementproducts when skin contact isavoided; products containing
this ingredient should beaccompanied with directions
to avoid skin contactbecause of the sensitizingpotential of methacrylates
IJT 24(S5):53-100,2005
Cyclomethicone (amended) 1 up to 89% JACT 10 (1):9-19,1991 (original
report); IJT30(S3):149-227, 2011
Cyclopentasiloxane (amended) 1 up to 93% IJT 30(S3):149-227,2011
Cyclotetraglucose 1 Final report 09/2015available from CIR
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Cyclotetrasiloxane (amended) 1 up to 28% IJT 30(S3):149-227,2011
Cynara Cardunculus Seed Oil 1 not in current use* Final report 03/11available from CIR
Cysteine 1 0.0001 to 5% IJT 32(S4):41-64,2013
Cysteine HCl 1 0.0001 to 6% IJT 32(S4):41-64,2013
Cystine 1 0.001 to 3% IJT 32(S4):41-64,2013
DEA-C12-13 Alkyl Sulfate 1 safe in the present practicesof use and concentrationwhen formulated to benon-irritating, except
do not use in cosmeticproducts in which N-nitrosocompounds can be formed
Final report 09/11available from CIR
DEA-C12-13 Pareth Sulfate 1 safe in the present practicesof use and concentrationwhen formulated to benon-irritating, except
do not use in cosmeticproducts in which N-nitrosocompounds can be formed
Final report 09/11available from CIR
DEA-C12-15 Alkyl Sulfate 1 safe in the present practicesof use and concentrationwhen formulated to benon-irritating, except
do not use in cosmeticproducts in which N-nitrosocompounds can be formed
Final report 09/11available from CIR
DEA-Cetyl Sulfate 1 safe in the present practicesof use and concentrationwhen formulated to benon-irritating, except
do not use in cosmeticproducts in which N-nitrosocompounds can be formed
Final report 09/11available from CIR
DEA-Cocamphodipropionate 1 safe in the present practicesof use and concentrationwhen formulated to benon-irritating, except
do not use in cosmeticproducts in which N-nitrosocompounds can be formed
Final report 09/11available from CIR
DEA-Dodecylbenzenesulfonate (amended) 1 safe in the present practicesof use and concentrationwhen formulated to be
IJT 29 (S4): 288-305,2010 - Final amended
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
non-irritating, exceptdo not use in cosmetic
products in which N-nitrosocompounds can be formed
report 09/11 availablefrom CIR
DEA-Isostearate 1 safe in the present practicesof use and concentrationwhen formulated to benon-irritating, except
do not use in cosmeticproducts in which N-nitrosocompounds can be formed
Final report 09/11available from CIR
DEA-Laureth Sulfate 1 safe in the present practicesof use and concentrationwhen formulated to benon-irritating, except
do not use in cosmeticproducts in which N-nitrosocompounds can be formed
Final report 09/11available from CIR
DEA-Lauryl Sulfate 1 safe in the present practicesof use and concentrationwhen formulated to benon-irritating, except
do not use in cosmeticproducts in which N-nitrosocompounds can be formed
Final report 09/11available from CIR
DEA- Linoleate 1 safe in the present practicesof use and concentrationwhen formulated to benon-irritating, except
do not use in cosmeticproducts in which N-nitrosocompounds can be formed
Final report 09/11available from CIR
DEA-Methyl Myristate Sulfonate 1 safe in the present practicesof use and concentrationwhen formulated to benon-irritating, except
do not use in cosmeticproducts in which N-nitrosocompounds can be formed
Final report 09/11available from CIR
DEA-Myreth Sulfate 1 safe in the present practicesof use and concentrationwhen formulated to benon-irritating, except
do not use in cosmeticproducts in which N-nitrosocompounds can be formed
Final report 09/11available from CIR
DEA-Myristate 1 safe in the present practicesof use and concentrationwhen formulated to be
Final report 09/11available from CIR
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
non-irritating, exceptdo not use in cosmetic
products in which N-nitrosocompounds can be formed
DEA-Myristyl Sulfate 1 safe in the present practicesof use and concentrationwhen formulated to benon-irritating, except
do not use in cosmeticproducts in which N-nitrosocompounds can be formed
Final report 09/11available from CIR
DEA-Stearate 1 safe in the present practicesof use and concentrationwhen formulated to benon-irritating, except
do not use in cosmeticproducts in which N-nitrosocompounds can be formed
Final report 09/11available from CIR
Decene/butene copolymer 1 safe as used Final report 06/2015available from CIR
Deceth-10 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Deceth-3 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Deceth-5 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Deceth-6 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Deceth-7 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Deceth-8 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Deceth-9 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Decyl betaine 1 not in current use * safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2014available from CIR
Decyl Castorate 1 not in current use * safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Decyl Cocoate (amended) 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 30(S1):5S-16S;final report 03/2013available from CIR
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Decylene Glycol 1 concentration not reported* IJT 31 (S2): 147-168,2012
Decyl Glucoside 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 32 (S3): 22-48,2013
Decyl Isostearate 1 not in current use * safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Decyl Jojobate 1 not in current use * safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Decyl Laurate 1 not in current use * safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Decyl Myristate 1 not in use at the time* safe for use in cosmetics whenformulated to be non-irritating
IJT29(S3) :162-186,2010;
final report 03/2013available from CIR
Decyl Oleate 1 up to 88% safe for use in cosmetics whenformulated to be non-irritating
JACT 1(2):85-95,1982 confirmed
11/01 IJT22(S1):1-35, 2003;
final report 03/2013available from CIR
Decyl Olivate 1 safe for use in cosmeticswhen formulated
to be non- irritating
Final report 03/2013available from CIR
Decyl Palmitate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Decyl succinate 1 not in use at the time* IJT 31 (S1):5-76,2012
Decyltetradeceth-10 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
Decyltetradeceth-15 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
Decyltetradeceth-20 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
Decyltetradeceth-25 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
Decyltetradeceth-30 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
Decyltetradeceth-5 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
Decyltetradecyl Cetearate 1 not in current use * safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Decyltetradecyl ethylhexanoate 1 not in current use * safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Defatted Citrus Unshiu Fruit 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-on
Final report 12/2015available from CIR
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
products do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Dehydroacetic Acid 1 up to 0.7% JACT 4(3):123-59, 1985 confirmed
11/03 IJT 25(S2),2006
Dehydroxanthan gum 1 0.1 to 1% Final report 09/12available from CIR
Denatonium Benzoate 1 1/16 avoidupois ounceper 100 gal alcohol
IJT 27 (S1):1-43,2008
Dextran 1 0.000005 to 0.2% Final report 09/12available from CIR
Dextran hydroxypropyltrimonium chloride 1 not in current use * Final report 09/12available from CIR
Dextran sulfate 1 0.01 to 0.1% Final report 09/12available from CIR
Dextrin 1 Final report 09/2015available from CIR
Dextrin Behenate 1 Final report 09/2015available from CIR
Dextrin Isostearate 1 Final report 09/2015available from CIR
Dextrin Laurate 1 Final report 09/2015available from CIR
Dextrin Myristate 1 Final report 09/2015available from CIR
Dextrin Palmitate 1 Final report 09/2015available from CIR
Dextrin Palmitate/Ethylhexanoate 1 Final report 09/2015available from CIR
Dextrin Stearate 1 Final report 09/2015available from CIR
Diammonium citrate 1 concentration not reported* IJT 33 (S2): 16-46,2014
Diammonium EDTA 1 not in current use * IJT 21 (S2):95-142,2002
Diamyl sodium sulfosuccinate 1 not in current use * safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2013available from CIR
Diazolidinyl Urea 1 up to 0.5% JACT 9(2):229-45, 1990 confirmed
12/06Dibehenyl Fumarate 1 not in current use * Final report 03/09 -
Available from CIRDibutyl Adipate (Amended) 1 concentration not reported
in 2010; 5 to 8% in 1996IJT 25(S1):129-134,
2006 JACT15(4):295-300, 1996
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
(original Report);Final report 12/10
available from CIRDibutyloctyl malate 1 not in current use* IJT 34(S1): 5-17,
2015Dibutyloctyl sebacate 1 not in current use* IJT 31(S1):5-76,
2012Dibutyl Phthalate 1 up to 15% JACT 4(3):267-
303, 1985confirmed 11/02 IJT24(S1):34-42, 2005reconfirmed 09/05
Dibutyl sebacate 1 not in current use* Final report 12/10available from CIR
Di-C12-13 Alkyl Malate 1 1.0 to 36% IJT 34(S1): 5-17,2015
Di-C12 - 15 Alkyl Adipate 1 not in current use* IJT 31(S1):5-76,2012
Di-C12 - 15 Alkyl Fumarate 1 up to 5% Safety Assessment03/09 - Available
from CIRDicapryl/capryl sebacate 1 not in use at the time* IJT 31 (S1):5-76,
2012Dicapryl adipate 1 concentration not reported* IJT 31 (S1):5-76,
2012Dicapryl sodium sulfosuccinate 1 not in current use * safe for use in cosmetics when
formulated to be non-irritatingFinal report 09/13
available from CIRDicapryl succinate 1 not in use at the time* IJT 31 (S1):5-76,
2012Dicetearyl Dimer Dilinoleate 1 up to 7% IJT 22 (S2):45-61,
2003Dicetearyl succinate 1 not in use at the time* IJT 31 (S1):5-76,
2012Dicetyl adipate 1 not in use at the time* IJT 31 (S1):5-76,
2012Dicetyl phosphate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 09/2014
available from CIRDicetyl Thiodipropionate 1 safe for use in cosmetic
formulations when formulatedto be non-irritating
JACT 11(1):25-41,1992 (original
report); JACT 29(S3): 137-150, 2010
Dichlorophene 1 IJT 23(S1):1-27 2004Diethanolamine 1 safe in the present practices
of use and concentrationwhen formulated to benon-irritating, except
do not use in cosmetic
JACT 2 (7):183-235,1983 - Final amended
report 09/11
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
products in which N-nitrosocompounds can be formed
Diethanolamine Bisulfate 1 safe in the present practicesof use and concentrationwhen formulated to benon-irritating, except
do not use in cosmeticproducts in which N-nitrosocompounds can be formed
Final amended report09/11
Diethyl adipate 1 not in current use* IJT 31(S1):5-76,2012
Diethylene glycol diethyl-hexanoate/diisononanoate 1 up to 19% IJT 30(S3):228-269,2011
Diethylene Glycol Diisononanoate 1 not in current use* IJT 30(S3):228-269,2011
Diethylhexyl Adipate 1 0.6 to 14% JACT 3 (3):101-30,1984 confirmed
06/03 IJT24(S1):44-47, 2005;
Final report 12/10available from CIR
Diethylhexyl Dimer Dilinoleate 1 1 IJT 22 (S2):45-61,2003
Diethylhexyl Fumarate 1 not in current use * Final report 03/09 -Available from CIR
Diethylhexyl Malate 1 0.4 to 2% IJT 34(S1): 5-17,2015
Diethylhexyl sebacate 1 not in current use* Final report 12/10available from CIR
Diethylhexyl Sodium Sulfosuccinate 1 5% IJT (S4):1-20, 1998;Final report 09/2013
available from CIRDiethylhexyl succinate 1 0.02 to 6% IJT 31 (S1):5-76,
2012Diethyl malonate 1 0.004 to 0.02% IJT 31 (S1):5-76,
2012Diethyl Phthalate 1 up to 2% JACT 4(3):267-
303, 1985confirmed 11/02 IJT24(S1):34-42, 2005reconfirmed 09/05
Diethyl sebacate 1 1.50% IJT 31(S1):5-76,2012
Diethyl succinate 1 not in current use* IJT 31 (S1):5-76,2012
Di-HEMA Trimethylhexyl Dicarbamate 1 safe in nail enhancementproducts when skin contact isavoided; products containing
IJT 24(S5):53-100,2005
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
this ingredient should beaccompanied with directions
to avoid skin contactbecause of the sensitizingpotential of methacrylates
Diheptyl sodium sulfosuccinate 1 Final report 09/2013available from CIR
Diheptylundecyl adipate 1 6% Final report 12/10available from CIR
Dihexyl adipate 1 3% Final report 12/10available from CIR
Dihexyldecyl adipate 1 not in use at the time* Final report 12/10available from CIR
Dihexyldecyl sebacate 1 0.5 to 5% Final report 12/10available from CIR
Dihexyl sodium sulfosuccinate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2013available from CIR
Dihydrogenated tallow benzylmonium hectorite 1 not in use at the time* IJT 32(S4):33-40,2013
Dihydrophytosteryl octyldecanoate 1 not in current use* Final report 12/2013available from CIR
Diisoamyl Malate 1 not in current use* IJT 34(S1): 5-17,2015
Diisobutyl adipate 1 0.001 to 3% Final report 12/10available from CIR
Diisobutyl glutarate 1 not in use at the time* Final report 12/10available from CIR
Diisobutyl sodium sulfosuccinate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2013available from CIR
Diisobutyl succinate 1 not in use at the time* Final report 12/10available from CIR
Diisocetyl adipate 1 not in use at the time* Final report 12/10available from CIR
Diisocetyl dodecanedioate 1 0.9 to 7% IJT 31 (S1):5-76,2012
Diisodecyl adipate 1 concentration not reported* Final report 12/10available from CIR
Diisononyl adipate 1 not in use at the time* Final report 12/10available from CIR
Diisooctyl adipate 1 not in use at the time* Final report 12/10available from CIR
Diisooctyl sebacate 1 1 to 3% Final report 12/10available from CIR
Diisopropanolamine 1 safe for use in cosmeticproducts; but should not beused in products containing
N-nitrosating agents
JACT 6(1):53-76,1987 confirmed12/04
IJT 25(S2), 2006
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Diisopropyl Adipate 1 0.005 to 8% JACT 3 (3):101-30,1984 confirmed
06/03 IJT24(S1):44-47, 2005;
Final report 12/10available from CIR
Diisopropylamine 1 safe for use in cosmeticproducts; but should not beused in products containing
N-nitrosating agents
JACT 14(3):182-92,1995 confirmed
12/09
Diisopropyl Dimer Dilinoleate 1 up to 53% IJT 22(S2):45-61,2003
Diisopropyl sebacate 1 0.06 to 10% IJT 31 (S1):5-76,2012
Diisostearyl adipate 1 3 to 10% Final report 12/10available from CIR
Diisostearyl Dimer Dilinoleate 1 up to 12% IJT 22(S2):45-61,2003
Diisostearyl Fumarate 1 up to 20% Final report 03/09 -Available from CIR
Diisostearyl Glutarate 1 not in current use* Final report 12/10available from CIR
Diisostearyl malate 1 0.001 to 82% IJT 34(S1): 5-17,2015
Diisostearyl sebacate 1 0.005 to 0.7% IJT 31 (S1):5-76,2012
Dilauryl citrate 1 concentration not reported* IJT 33 (S2): 16-46,2014
Dilauryl Thiodipropionate 1 safe for use in cosmeticformulations when formulated
to be non-irritating
JACT 11(1):25-41,1992 (original
report); JACT 29(S3): 137-150, 2010
Dilinoleamidopropyl dimethylamine 1 not in current use* safe in cosmetics as longas they are formulatedto be non-sensitizing,
which may be based on aquantitative risk assessment
Final report 06/2014available from CIR
Dimethicone 1 up to 80% in hairpreparations; up
to 24% in makeup
IJT 22(S2):11-35,2003
Dimethicone/bis-isobutyl PPG-20 crosspolymer 1 concentration not reported* IJT 33 (S2): 65-115,2014
Dimethicone/bis-vinyldimethicone/silsesquioxanecrosspolymer
1 0.5 to 5% IJT 33 (S2): 65-115,2014
Dimethicone/divinyldimethicone/silsesquioxanecrosspolymer
1 0.5 to 5% IJT 33 (S2): 65-115,2014
Dimethicone/lauryl dimethicone/bis-vinyldimethiconecrosspolymer
1 not in current use* IJT 33 (S2): 65-115,2014
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Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Dimethicone/PEG-10/15 crosspolymer 1 0.03 to 3% IJT 33 (S2): 65-115,2014
Dimethicone/PEG-10 crosspolymer 1 0.50% IJT 33 (S2): 65-115,2014
Dimethicone/PEG-15 crosspolymer 1 not in current use* IJT 33 (S2): 65-115,2014
Dimethicone/phenyl vinyl dimethicone crosspolymer 1 0.8 to 2% IJT 33 (S2): 65-115,2014
Dimethicone/PPG-20 crosspolymer 1 0.20% IJT 33 (S2): 65-115,2014
Dimethicone/titanate crosspolymer 1 not in current use* IJT 33 (S2): 65-115,2014
Dimethicone/vinyl dimethicone crosspolymer 1 0.003 to 46% IJT 33 (S2): 65-115,2014
Dimethicone/vinyltrimethylsiloxysilicate crosspolymer 1 0.04 to 6% IJT 33 (S2): 65-115,2014
Dimethicone Copolyol 1 up to 1% JACT 1(4):33- 54,1982 confirmed
02/03 IJT24(S1):42-44, 2005
Dimethicone crosspolymer 1 0.007 to 25% IJT 33 (S2): 65-115,2014
Dimethicone crosspolymer-3 1 0.2 to 2% IJT 33 (S2): 65-115,2014
Dimethicone PEG/PPG-7/4 Phosphate, DimethiconePEG/PPG-12/4 Phosphate, Dimethicone PEG/PPG-20/23Benzoate
3 concentration not reported* JACT 1(4):33-54,1982 4 confirmed
02/03 IJT24(S1):42-44, 2005
Dimethicone PEG-10 Phosphate 1 concentration not reported* JACT 1(4):33-54,1982 4 confirmed
02/03 IJT24(S1):42-44, 2005
Dimethicone PEG-6 Acetate 1 concentration not reported* JACT 1(4):33-54,1982 4 confirmed
02/03 IJT24(S1):42-44, 2006
Dimethicone PEG-7 Phosphate 1 up to 0.5% JACT 1(4):33-54,1982 4 confirmed
02/03 IJT24(S1):42-44, 2005
Dimethicone PEG-8 Adipate 1 concentration not reported* JACT 1(4):33-54,1982 4 confirmed
02/03 IJT24(S1):42-44, 2007
Dimethicone PEG-8 Benzoate 1 up to 0.5% JACT 1 (4):33-54,1982 4 confirmed
02/03 IJT24(S1):42-44, 2005
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Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Dimethiconol 1 0.004 to 36% IJT 33 (S2): 65- 115,2014
Dimethiconol/methylsilanol/silicate crosspolymer 1 not in use at the time* Final report 12/10available from CIR
Dimethiconol/silica crosspolymer 1 not in use at the time* Final report 12/10available from CIR
Dimethiconol/silsesquioxane copolymer 1 0.30% Final report 12/10available from CIR
Dimethiconol/stearyl methicone/phenyl trimethiconecopolymer
1 not in use at the time* Final report 12/10available from CIR
Dimethiconol arginine 1 concentration not reported* Final report 12/10available from CIR
Dimethiconol beeswax 1 0.8 to 0.9% Final report 12/10available from CIR
Dimethiconol behenate 1 0.50% Final report 12/10available from CIR
Dimethiconol borageate 1 0.50% Final report 12/10available from CIR
Dimethiconol candelillate 1 not in use at the time* Final report 12/10available from CIR
Dimethiconol carnaubate 1 not in use at the time* Final report 12/10available from CIR
Dimethiconol cysteine 1 0.07% Final report 12/10available from CIR
Dimethiconol dhupa butterate 1 not in use at the time* Final report 12/10available from CIR
Dimethiconol hydroxystearate 1 not in use at the time* Final report 12/10available from CIR
Dimethiconol illipe butterate 1 not in use at the time* Final report 12/10available from CIR
Dimethiconol isostearate 1 not in use at the time* Final report 12/10available from CIR
Dimethiconol kokum butterate 1 not in use at the time* Final report 12/10available from CIR
Dimethiconol lactate 1 not in use at the time* Final report 12/10available from CIR
Dimethiconol meadowfoamate 1 0.5 to 1% Final report 12/10available from CIR
Dimethiconol methionine 1 concentration not reported* Final report 12/10available from CIR
Dimethiconol mohwa butterate 1 not in use at the time* Final report 12/10available from CIR
Dimethiconol panthenol 1 0.07% Final report 12/10available from CIR
Dimethiconol sal butterate 1 not in use at the time* Final report 12/10available from CIR
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Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Dimethiconol stearate 1 1% Final report 12/10available from CIR
Dimethoxysilyl Ethylenediaminopropyl Dimethicone 1 not in current use1 * IJT 22(S2):11-35,2003
Dimethyl adipate 1 0.20% Final report 12/10available from CIR
Dimethyl Behenamine 1 not in current use * Amended FinalReport 12-09 -
available from CIRJACT 14(3):193-95,
1995 (original report)Dimethyl Cocamine 1 not in current use * Amended Final
Report 12-09 -available from CIR
JACT 14(3):193-95,1995 (original report)
Dimethyl glutarate 1 0.5 to 15% Final report 12/10available from CIR
Dimethyl Hydrogenated Tallowamine 1 not in current use * Amended FinalReport 12-09 -
available from CIRJACT 14(3):193-95,
1995 (original report)Dimethyl Lauramine 1 not in current use * Amended Final
Report 12-09 -available from CIR
JACT 14(3):193-95,1995 (original report)
Dimethyl Myristamine 1 not in current use * Amended FinalReport 12-09 -
available from CIRJACT 14(3):193-95,
1995 (original report)Dimethyl Palmitamine 1 not in current use * Amended Final
Report 12-09 -available from CIR
JACT 14(3):193-95,1995 (original report)
Dimethyl Phthalate 1 up to 2% JACT 4(3):267-303, 1985
confirmed 11/02 IJT24(S1):34-42, 2005reconfirmed 09/05
Dimethyl Soyamine (amended) 1 not in current use * Amended FinalReport 12-09 -
available from CIRJACT 14(3):193-95,
1995 (original report)
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Dimethyl Stearamine (amended) 1 up to 4% in non-coloringhair care products
Amended FinalReport 12-09 -
available from CIRJACT 14(3):193-95,
1995 (original report)Dimethyl succinate 1 not in use at the time* IJT 31 (S1):5-76,
2012Dimethyl Tallowamine 1 not in current use * Amended Final
Report 12-09 -available from CIR
JACT 14(3):193-95,1995 (original report)
Dimyristyl Phosphate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2014available from CIR
Dimyristyl Thiodipropionate 1 safe for use in cosmeticformulations when formulated
to be non-irritating
JACT 11(1):25-41,1992 (original
report); JACT 29(S3): 137-150, 2010
Dioctyl Adipate 1 up to 38% JACT 3(3):101-30,1984 confirmed
06/03 IJT24(S1):44-47, 2005
Dioctyl Dimer Dilinoleate 1 up to 12% IJT 22 (S2):45-61,2003
Dioctyldocecyl Adipate 1 concentration not reported* Final report 12/10available from CIR
Dioctyldocecyl Dimer Dilinoleate 1 up to 10% IJT 22(S2):45-61,2003
Dioctyldocecyl Dodecanedioate 1 not in use at the time* Final report 12/10available from CIR
Dioctyldocecyl Sebacate 1 3 to 8% Final report 12/10available from CIR
Dioctyldodecyl malate 1 not in current use* IJT 34(S1): 5-17,2015
Dioctyl Sodium Sulfosuccinate 1 5% IJT 17 (S4):1-20,1998
Dioleyl Phosphate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2014available from CIR
Dioleyl Tocopheryl Methylsilanol 1 6% IJT 21 (S3):51-116,2002; Final report03/2014 available
from CIRDioscorea Villosa (Wild Yam) Root Extract 1 up to 15% of max.
2% plant solidsIJT 23(S2):49-54,
2004Dipalmitoyl cysteine 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 12/2013
available from CIRDipentaerythrityl pentaisononanoate 1 up to 13% IJT 30(S3):228-269,
2011
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Diphenyl dimethicone /vinyl diphenyl dimethicone/silsesquioxane crosspolymer
1 0.1 to 7% Final report 09/12available from CIR
Diphenyl dimethicone crosspolymer 1 not in current use* Final report 09/12available from CIR
Dipotassium Aspartate 1 not in current use* IJT 32(S4):41-64,2013
Dipotassium Azelate 1 not in use at the time* IJT 31 (S1):5-76,2012
Dipotassium capryloyl glutamate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Dipotassium EDTA 1 less than 0.1% IJT 21 (S2):95-142,2002
Dipotassium Glycyrrhizate 1 up to 1% IJT 26 (S2):79-112,2007
Dipotassium undecylenoyl glutamate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Dipropyl adipate 1 not in current use * Final report 12/10available from CIR
Dipropylene Glycol 1 up to 50% JACT 4(5):223-48, 1985 confirmed
02/04 IJT 25(S2),2006
Disodium azelate 1 not in current use * IJT 31 (S1):5-76,2012
Disodium C12-14 pareth-1 sulfosuccinate 1 safe in the present practices ofuse and concentration when
formulated to be non-irritating
Final report 03/12available from CIR
Disodium C12-14 pareth-2 sulfosuccinate 1 safe in the present practices ofuse and concentration when
formulated to be non-irritating
Final report 03/12available from CIR
Disodium C12-14 sec-pareth-12 sulfosuccinate 1 safe in the present practices ofuse and concentration when
formulated to be non-irritating
Final report 03/12available from CIR
Disodium C12-14 sec-pareth-3 sulfosuccinate 1 safe in the present practices ofuse and concentration when
formulated to be non-irritating
Final report 03/12available from CIR
disodium C12-14 sec-pareth-5 sulfosuccinate 1 safe in the present practices ofuse and concentration when
formulated to be non-irritating
Final report 03/12available from CIR
Disodium C12-14 sec-pareth-7 sulfosuccinate 1 safe in the present practices ofuse and concentration when
formulated to be non-irritating
Final report 03/12available from CIR
Disodium C12-14 sec-pareth-9 sulfosuccinate 1 safe in the present practices ofuse and concentration when
formulated to be non-irritating
Final report 03/12available from CIR
Disodium C12-15 pareth sulfosuccinate 1 safe in the present practices ofuse and concentration when
formulated to be non-irritating
Final report 03/12available from CIR
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Disodium capryloyl glutamate 1 safe for use in cosmetics aslong as they are formulated
to be non-irritating
Final report 12/2013available from CIR
Disodium coceth-3 sulfosuccinate 1 safe in the present practices ofuse and concentration when
formulated to be non-irritating
Final report 03/12available from CIR
Disodium Cocoamphodiacetate 1 0.0006 to 12% JACT 9(2):121-142,1990; re-review IJT
27(Suppl. 1):77-142,2008
Disodium Cocoamphodipropionate 1 0.008 to 15% JACT 9(2):121-142,1990; re-review IJT
27(Suppl. 1):77-142,2008
Disodium cocoyl glutamate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Disodium cupric citrate 1 not in current use* IJT 33 (S2): 16-46,2014
Disodium deceth-5 sulfosuccinate 1 safe in the present practices ofuse and concentration when
formulated to be non-irritating
Final report 03/12available from CIR
disodium deceth-6 sulfosuccinate 1 safe in the present practices ofuse and concentration when
formulated to be non-irritating
Final report 03/12available from CIR
Disodium Deceth Sulfate 1 not in current use * IJT29(S3) :151-161,2010
Disodium EDTA 1 less than 1% IJT 21(S2):95-142,2002
Disodium Fumarate 1 not in current use * Final report 03/09 -Available from CIR
Disodium Glycyrrhizate 1 not in current use * IJT 26(S2):79-112,2007
Disodium hydrogenated tallow glutamate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Disodium laneth-5 sulfosuccinate 1 safe in the present practices ofuse and concentration when
formulated to be non-irritating
Final report 03/12available from CIR
Disodium laureth-12 sulfosuccinate 1 safe in the present practices ofuse and concentration when
formulated to be non-irritating
Final report 03/12available from CIR
Disodium laureth-6 sulfosuccinate 1 safe in the present practices ofuse and concentration when
formulated to be non-irritating
Final report 03/12available from CIR
Disodium laureth-9 sulfosuccinate 1 safe in the present practices ofuse and concentration when
formulated to be non-irritating
Final report 03/12available from CIR
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Disodium laureth sulfosuccinate 1 safe in the present practices ofuse and concentration when
formulated to be non-irritating
Final report 03/12available from CIR
Disodium Lauriminodipropionate 1 not in current use * IJT 32 (S3):49-55,2013
Disodium lauroyl glutamate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Disodium Lauryl phosphate 1 not in current use * safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2014available from CIR
Disodium malyl tyrosinate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2014available from CIR
Disodium N-lauroyl aspartate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Disodium oleth-3 sulfosuccinate 1 safe in the present practices ofuse and concentration when
formulated to be non-irritating
Final report 03/12available from CIR
Disodium oleyl phosphate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2014available from CIR
Disodium sebacate 1 not in current use * IJT 31 (S1):5-76,2012
Disodium stearoyl glutamate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Disodium Succinate 1 0.0005 to 0.4% IJT 31 (S1):5-76,2012
Disodium Succinoyl Glycyrrhetinate 1 not reported * IJT 26(S2):79-112,2007
Disodium undecylenoyl glutamate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Disperse Black 9 1 up to 0.5% JACT 5(3):205-23,1986 confirmed
12/06Disperse Blue 1 1 up to 1% JACT 14(6):433-51,
1995; confirmed03/2011
Disperse Blue 7 1 IJT 26(S2):65-77,2007
Disperse Violet 1 1 up to 1% JACT 10(1):103-11,1991
Disperse Yellow 3 1 JACT 15(4):301-10,1996
Disteardimonium hectorite 1 0.04 to 28% IJT 32 (S4):33-40,2013
Distearyl citrate 1 not in current use * IJT 33 (S2): 16-46,2014
Distearyl Thiodipropionate 1 safe for use in cosmeticformulations when formulated
to be non-irritating
JACT 11(1):25-41,1992 (original
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
report); JACT 29(S3): 137-150, 2010
Di-t-Butylhydroquinone 1 JACT 15(4):311-9,1996
Ditridecyl Adipate 1 not in current use * Final report 12/10available from CIR
Ditridecyl Dimer Dilinoleate 1 not in current use * IJT 22(S2):45-61,2003
Ditridecyl sodium sulfosuccinate 1 not in current use * safe for use in cosmetics whenformulated to be non-irritating
Final report 09/13available from CIR
Ditridecyl Thiodipropionate (dialkyl esters) 1 safe for use in cosmeticformulations when formulated
to be non-irritating
JACT 11(1):25-41,1992 (original
report); JACT 29(S3): 137-150, 2010
Divinyldimethicone/dimethicone crosspolymer 1 0.007 to 0.7% Final report 09/12available from CIR
DMDM Hydantoin 1 up to 1% JACT 7(3):245-77,1988 confirmed
09/05Dmethicone/polyglycerin-3 crosspolymer 1 concentration not reported* IJT 33 (S2): 65-115,
2014Dodecanedioic acid 1 not in current use * IJT 31 (S1):5-76,
2012Dodecylhexadecyl-trimonium chloride 1 safe when formulated
to be non- irritatingIJT 31(S3): 296-341
(2012)Drometrizole 1 0.07% IJT 27(S2): 63-75,
2008 JACT5(5):455-70, 1986
(original report)EDTA 1 up to 2% IJT 21(S2):95-142,
2002Elaeis (Palm) Fruit Oil 1 not in current use* Final report 03/11
available from CIRElaeis Guineensis (Palm) Butter 1 not in current use* Final report 03/11
available from CIRElaeis Guineensis (Palm) Kernel Oil 1 0.05 to 23% Final amended report
03/11 availablefrom CIR; IJT 19
(S2):7-28, 2000(original)
Elaeis Guineensis (Palm) Oil 1 up to 2% Final amended report03/11 available
from CIR; IJT 19(S2):7-28, 2000
(original)Elaeis Oleifera Kernel Oil 1 Final report 03/11
available from CIR
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Elastin Amino Acids 1 not in current use* IJT 33(S4):5-12,2014
Emulsifying Wax N.F. 1 up to 21% JACT 3(3):43- 99,1984 confirmed
06/03 IJT24(S1):67-74, 2005
Erucyl Arachidate 1 not in current use* safe when formulatedto be non-irritating
Final report 03/13available from CIR
Erucyl Erucate 1 not in current use* safe when formulatedto be non-irritating
Final report 03/13available from CIR
Erucyl Oleate 1 not in current use* safe when formulatedto be non-irritating
Final report 03/13available from CIR
Erythorbic Acid 1 up to 1% IJT 18(S3):1-26,1999
Ethanolamine (amended) 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
Final amended report03/12 available
from CIR; JACT2(7):183-235, 1983
(original report)
Ethanolamine HCl 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
Final amended report03/12 available
from CIR; JACT2(7):183-235, 1983
(original report)
Ethanolamine Thioglycolate 1 in hair straighteners,permanent waves, tonics,dressings, etc., wave sets,other non-coloring hairproducts, and hair dyes
and colors; safe at 15.2%(as thioglycolic acid);
hairdressers should avoidskin contact and minimizeconsumer skin exposure
IJT 28(S3):68-133,2009
Ethoxydiglycol 1 up to 80% JACT 4(5):223-48,1985 confirmed
02/04 IJT 25(S2),2006
Ethoxyethanol 1 reproductive &developmental toxicity
IJT 21(S1):9-62,2002
Ethoxyethanol Acetate 1 reproductive &developmental toxicity
IJT 21(S1):9-62,2002
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Ethoxyethyl Methacrylate 1 safe in nail enhancementproducts when skin contact isavoided; products containing
this ingredient should beaccompanied with directions
to avoid skin contactbecause of the sensitizingpotential of methacrylates
IJT 24(S5):53-100,2005
Ethyl Acetate 1 greater than 50% JACT 8(4):681-705,1989 confirmed
08/06Ethyl Benzoate 1 0.0008 to 0.01% IJT 31(3):342 -372
(2012)Ethylcellulose (amended) 1 up to 4% Amended safety
assessment 03/09Ethyl citrates 1 0.5 to 1% in rinse-off IJT 33 (S2): 16-46,
2014Ethylene/Acrylic Acid/VA Copolymer 1 safe for use when
formulated to avoid irritationIJT 21(S3):1-50,
2002Ethylene/Acrylic Acid Copolymer 1 safe for use when
formulated to avoid irritationIJT 21(S3):1-50,
2002Ethylene/Calcium Acrylate Copolymer 1 safe for use when
formulated to avoid irritationIJT 21(S3):1-50,
2002Ethylene/Magnesium Acrylate Copolymer 1 safe for use when
formulated to avoid irritationIJT 21(S3):1-50,
2002Ethylene/Methacrylate Copolymer 1 safe for use when
formulated to avoid irritationIJT 21(S3):1-50,
2002Ethylene/octene copolymer* 1 safe as used Final report 06/2015
available from CIREthylene/propylene/styrene copolymer 1 Final report 09/2014
available from CIREthylene/propylene copolymer 1 safe as used Final report 06/2015
available from CIREthylene/Sodium Acrylate Copolymer 1 safe for use when
formulated to avoid irritationIJT 21(S3):1-50,
2002Ethylene/Zinc Acrylate Copolymer 1 safe for use when
formulated to avoid irritationIJT 21(S3):1-50,
2002Ethylene Glycol Dimethacrylate 1 safe in nail enhancement
products when skin contact isavoided; products containing
this ingredient should beaccompanied with directions
to avoid skin contactbecause of the sensitizingpotential of methacrylates
IJT 24(S5):53-100,2005
Ethyl Ester of PVM/MA Copolymer (amended) 1 up to 30% Amended FinalReport 06/09
Available from CIR
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
JACT 12(3):243-56,1993 (original report)
Ethyl Glucoside 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 32 (S3): 22-48,2013
Ethyl Glycolate and Ethyl Lactate 1 safe for use in cosmeticproducts at concentrationsless than or equal to10%,at final formulation pH
greater than or equal to3.5,when formulated to avoidincreasing sun sensitivityor when directions for use
include the daily use of sunprotection. These ingredients
are safe for use in sal
IJT 17(S1):1-242,1998
Ethyl Hexanediol 1 5% in 1984, butnot in current use *
JACT 13(6):418-36,1994 confirmed
09/09Ethylhexyl Adipate/Palmitate/Stearate 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIREthylhexyl Benzoate 1 3 to 4% IJT 31(3):342-372
(2012)Ethylhexyl C10-40 Isoalkyl Acidate 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIREthylhexyl Cocoate (amended) 1 up to 41% safe for use in cosmetics when
formulated to be non-irritatingIJT 30(S1):5S-16S;
Final report 03/2013available from CIR
Ethylhexyl Ethylhexanoate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Ethylhexylglycerin 1 IJT 32 (S3): 5-21,2013
Ethylhexyl Hydroxystearate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Ethylhexyl isononanoate 1 up to 75% safe for use in cosmetics whenformulated to be non-irritating
IJT 30(S3):228-269,2011; final report03/2013 available
from CIREthylhexyl Isopalmitate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIREthylhexyl Isostearate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIREthylhexyl Laurate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIREthylhexyl Myristate 1 not in use at the time* safe for use in cosmetics when
formulated to be non-irritatingIJT
29(S3) :162-186,2010;final report 03/2013available from CIR
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Ethylhexyl Neopentanoate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Ethylhexyl Oleate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Ethylhexyl Olivate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Ethylhexyl Palmitate 1 up to 46% safe for use in cosmetics whenformulated to be non-irritating
JACT 1(2):13-35,1982 confirmed
09/01; final report03/2013 available
from CIREthylhexyl Pelargonate 1 2 to 25% safe for use in cosmetics when
formulated to be non-irritatingFinal report 06/10
available from CIR;Final report 03/2013
available from CIREthylhexyl Salicylate 1 safe when formulated to
avoid irritation and to avoidincreasing sun sensitivity,
or when increased sunsensitivity would be expected,directions for use include thedaily use of sun protection.
IJT 22(3):1-108
Ethylhexyl Stearate 1 up to 11% safe for use in cosmetics whenformulated to be non-irritating
JACT 4(5):107-46,1985 confirmed
06/03; final report03/2013 available
from CIREthyl Methacrylate (Amended) 1 safe as used when application
is accompanied by directionsto avoid skin contact because
of the sensitizing potential
IJT 21(S1):63-79,2002 JACT 14(6):
452-67, 1995(Original Report)
Ethyl Myristate 1 not in use at the time* IJT29(S3) :162-186,2010
Ethylparaben (amended) 1 up to 0.4% if used alone;parabens mixture up to 0.8%
IJT 27(S4): 1-82,2008 JACT
3(5):147-209, 1984(original report)
Ethyl Ricinoleate 1 not in current use * IJT 26(S3): 31-772007
Ethyl Thioglycolate 1 in hair straighteners,permanent waves, tonics,dressings, etc., wave sets,other non-coloring hairproducts, and hair dyes
and colors; safe at 15.2%(as thioglycolic acid);
hairdressers should avoid
IJT 28(S3):68-133,2009
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
skin contact and minimizeconsumer skin exposure
Euphorbia Cerifera (Candelilla) Wax 0 up to 27% JACT 3(3):1-41,1984 confirmed
06/03 IJT24(S1):48-52, 2005
Euterpe Oleracea Fruit Oil 1 0.00001 to 0.5% Final report 03/11available from CIR
Euterpe Oleracea sterols 1 Final report 12/2013available from CIR
Ferric citrate 1 0.5% in rinse-off;concentration not
reported for leave- on
IJT 33 (S2): 16-46,2014
Ferrous Fumarate 1 up to 0.0003% Final report 03/09 -Available from CIR
Fibroin 1 Final report 12/2015available from CIR
Formaldehyde 1 1 safe for use in cosmeticswhen formulated to
ensure use at the minimaleffective concentration,but in no case should theformalin concentration
exceed 0.2% (w/w), whichwould be 0.074% (w/w)
calculated as formaldehyde or0.118% (w/w) calculated as
IJT 32(Suppl.4):5-32, 2013; JACT
3(3):157-84, 1984confirmed 09/03 IJT
25(S2): 1-89, 2006
Formic Acid 1 less than or equal to64ppm of the free acid
IJT 16(S3):221-34,1997; Final report01/2014 available
from CIRFragaria Anannassa (Strawberry) Seed Oil 1 not in use at the time* Final report 03/11
available from CIRFragaria Chiloensis (Strawberry) Seed Oil 1 not in use at the time* Final report 03/11
available from CIRFragaria Vesca (Strawberry) Seed Oil 1 not in use at the time* Final report 03/11
available from CIRFragaria Virginiana (Strawberry) Seed Oil 1 not in use at the time* Final report 03/11
available from CIRFructose 1 Final report 03/2014
available from CIRFucose 1 not in current use* Final report 03/2014
available from CIRFullers Earth 1 up to 50% IJT 22(S1):37-102,
2003Fumaric Acid 1 up to 5% Final report 03/09 -
Available from CIR
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Galactoarabinan 1 Final report 09/2015available from CIR
Galactomannans (see CIR report of the same name) Final report 03/12available from CIR
Galactose 1 not in current use* Final report 03/2014available from CIR
Galactosyl Fructose 1 not in current use* Final report 03/2014available from CIR
Galacturonic Acid 1 not in current use* Final report 03/2014available from CIR
Garcinia Indica Seed Butter 1 0.1 to 2% Final report 03/2011available from CIR
Garcinia mangostana amino acids 1 not in current use* IJT 33(S4):5-12,2014
Gellan Gum 1 0.0004 to 0.5% Final report 09/12available from CIR
Gevuina Avellana Oil 1 0.002 to 0.2% Final report -3/11available from CIR
Gevuina Avellana Seed Oil 1 0.1 to 2% Final report -3/11available from CIR
Ghatti Gum 1 Final report 09/2015available from CIR
Glucomannan 1 Final report 09/2015available from CIR
Gluconic Acid 1 Final report 03/2014available from CIR
Glucose 1 Final report 03/2014available from CIR
Glucose Glutamate 1 IJT 19(S1):11-12,2000
Glutamic Acid 1 0.000004 to 2% IJT 32(S4):41-64,2013
Glutamine 1 0.002 to 0.005% IJT 32(S4):41-64,2013
Glutaral 1 less than 0.5% for rinse-off; but should not be usedin products intended to beaerosolized (insufficient
data to support safetyin leave-on products)
JACT 15(2):98-139,1996
Glutaric acid 1 not in current use * IJT 31 (S1):5-76,2012
Glycerin 1 Final report 12/2014available from CIR
Glyceryl/Sorbitol Oleate/Hydroxystearate 1 not in current use * IJT 23(S2):55-94,2004
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Glyceryl Acetate 1 Final report 12/2015available from CIR
Glyceryl Adipate 1 IJT 23(S2):55-94,2004;
Final report 12/2015available from CIR
Glyceryl Alginate 1 IJT 23 (S2):55-94,2004; Final report
09/2015 availablefrom CIR
Glyceryl Allyl Ether 1 not in current use* IJT 32 (S3): 5-21,2013
Glyceryl Arachidate 1 IJT 23(S2):55-94,2004;
Final report 12/2015available from CIR
Glyceryl Arachidonate 1 IJT 23(S2):55-94,2004
Glyceryl Behenate 1 IJT 23(S2):55-94,2004;
Final report 12/2015available from CIR
Glyceryl Caprate 1 IJT 23(S2):55-94,2004;
Final report 12/2015available from CIR
Glyceryl Caprylate 1 IJT 23(S2):55-94,2004;
Final report 12/2015available from CIR
Glyceryl Caprylate/Caprate 1 IJT 23(S2):55-94,2004;
Final report 12/2015available from CIR
Glyceryl Capryl Ether 1 not in current use* IJT 32 (S3): 5-21,2013
Glyceryl Citrate/Lactate/Linoleate/Oleate 1 IJT 23(S2):55-94,2004;
Final report 12/2015available from CIR
Glyceryl Cocoate 1 IJT 23 (S2):55-94,2004; Final report
12/2015 availablefrom CIR
Glyceryl Cocoate/Citrate/Lactate 1 Final report 12/2015available from CIR
Glyceryl Collagenate 1 not in current use * IJT 23(S2):55-94,2004
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Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Glyceryl Diarachidate 1 safe as cosmetic ingredientsin the practices of use andconcentration as describedin the safety assessment,provided that the content
of 1,2-diesters is nothigh enough to induceepidermal hyperplasia
IJT 26(S3):1-30,2007
Glyceryl Dibehenate 1 safe as cosmetic ingredientsin the practices of use andconcentration as describedin the safety assessment,provided that the content
of 1,2-diesters is nothigh enough to induceepidermal hyperplasia
IJT 26(S3):1-30,2007
Glyceryl Dierucate 1 safe as cosmetic ingredientsin the practices of use andconcentration as describedin the safety assessment,provided that the content
of 1,2-diesters is nothigh enough to induceepidermal hyperplasia
IJT 26(S3):1-30,2007
Glyceryl Dihydroxystearate 1 safe as cosmetic ingredientsin the practices of use andconcentration as describedin the safety assessment,provided that the content
of 1,2-diesters is nothigh enough to induceepidermal hyperplasia
IJT 26(S3):1-30,2007
Glyceryl Diisopalmitate 1 safe as cosmetic ingredientsin the practices of use andconcentration as describedin the safety assessment,provided that the content
of 1,2-diesters is nothigh enough to induceepidermal hyperplasia
IJT 26(S3):1-30,2007
Glyceryl Diisostearate 1 safe as cosmetic ingredientsin the practices of use andconcentration as describedin the safety assessment,provided that the content
of 1,2-diesters is nothigh enough to induceepidermal hyperplasia
IJT 26(S3):1-30,2007
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Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Glyceryl Dilaurate 1 safe as cosmetic ingredientsin the practices of use andconcentration as describedin the safety assessment,provided that the content
of 1,2-diesters is nothigh enough to induceepidermal hyperplasia
IJT 26(S3):1-30,2007
Glyceryl Dilinoleate 1 safe as cosmetic ingredientsin the practices of use andconcentration as describedin the safety assessment,provided that the content
of 1,2-diesters is nothigh enough to induceepidermal hyperplasia
IJT 26(S3):1-30,2007
Glyceryl Dimaltodextrin 1 Final report 09/2015available from CIR
Glyceryl Dimyristate 1 safe as cosmetic ingredientsin the practices of use andconcentration as describedin the safety assessment,provided that the content
of 1,2-diesters is nothigh enough to induceepidermal hyperplasia
IJT 23(S2):55-94,2004; IJT
26(S3):1-30, 2007
Glyceryl Dioleate 1 safe as cosmetic ingredientsin the practices of use andconcentration as describedin the safety assessment,provided that the content
of 1,2-diesters is nothigh enough to induceepidermal hyperplasia
IJT 26(S3):1-30,2007
Glyceryl Dipalmitate 1 safe as cosmetic ingredientsin the practices of use andconcentration as describedin the safety assessment,provided that the content
of 1,2-diesters is nothigh enough to induceepidermal hyperplasia
IJT 26(S3):1-30,2007
Glyceryl Dipalmitoleate 1 safe as cosmetic ingredientsin the practices of use andconcentration as describedin the safety assessment,provided that the content
of 1,2-diesters is not
IJT 26(S3):1-30,2007
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Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
high enough to induceepidermal hyperplasia
Glyceryl Diricinoleate 1 safe as cosmetic ingredientsin the practices of use andconcentration as describedin the safety assessment,provided that the content
of 1,2-diesters is nothigh enough to induceepidermal hyperplasia
IJT 26(S3):1-30,2007
Glyceryl Distearate 1 safe as cosmetic ingredientsin the practices of use andconcentration as describedin the safety assessment,provided that the content
of 1,2-diesters is nothigh enough to induceepidermal hyperplasia
IJT 26(S3):1-30,2007
Glyceryl Erucate 1 IJT 23 (S2):55-94,2004; Final report
12/2015 availablefrom CIR
Glyceryl Ethylhexanoate 1 Final report 12/2015available from CIR
Glyceryl Ethylhexanoate/Stearate/Adipate 1 Final report 12/2015available from CIR
Glyceryl Glycyrrhetinate 1 not in current use * IJT 26(S2):79-112,2007
Glyceryl Heptanoate 1 Final report 12/2015available from CIR
Glyceryl Hydrogenated Rapeseedate 1 Final report 12/2015available from CIR
Glyceryl Hydrogenated Rosinate 1 IJT 23(S2):55-94,2004;
Final report 12/2015available from CIR
Glyceryl Hydrogenated Soyate 1 IJT 23(S2):55-94,2004; Final report12/2015 available
from CIRGlyceryl Hydroxystearate 1 IJT 23 (S2):55-94,
2004; Final report12/2015 available
from CIRGlyceryl Isopalmitate 1 IJT 23(S2):55-94,
2004; Final report12/2015 available
from CIR
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Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Glyceryl Isostearate 1 IJT 23(S2):55- 94,2004; Final report12/2015 available
from CIRGlyceryl Isostearate/Myristate 1 not in current use * IJT 23(S2):55-94,
2004Glyceryl Isostearates 1 not in current use * IJT 23(S2):55-94,
2004Glyceryl Isotridecanoate/Stearate/Adipate 1 IJT 23(S2):55-94,
2004; Final report12/2015 available
from CIRGlyceryl Lanolate 1 IJT 23(S2):55-94,
2004; Final report12/2015 available
from CIRGlyceryl Laurate 1 IJT 23(S2):55-94,
2004; Final report12/2015 available
from CIRGlyceryl Laurate/Oleate 1 IJT 23(S2):55-94,
2004; Final report12/2015 available
from CIRGlyceryl Laurate SE 1 IJT 23(S2):55-94,
2004; Final report12/2015 available
from CIRGlyceryl Lauryl Ether 1 IJT 32 (S3): 5-21,
2013Glyceryl Linoleate 1 IJT 23(S2):55- 94,
2004; Final report12/2015 available
from CIRGlyceryl Linolenate 1 IJT 23(S2):55- 94,
2004; Final report12/2015 available
from CIRGlyceryl Montanate 1 IJT 23(S2):55-94,
2004; Final report12/2015 available
from CIRGlyceryl Myristate 1 up to 6% IJT 23(S2):55-94,
2004Glyceryl Oleate 1 JACT 5(5):391- 413;
Final report 12/2015available from CIR
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Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Glyceryl Oleate/Elaidate 1 IJT 23 (S2):55-94,2004; Final report12/2015 available
from CIRGlyceryl Oleate SE 1 IJT 23(S2):55-94,
2004; Final report12/2015 available
from CIRGlyceryl Olivate 1 Final report 12/2015
available from CIRGlyceryl Palmitate 1 IJT 23(S2):55-94,
2004; Final report12/2015 available
from CIRGlyceryl Palmitate/Stearate 1 IJT 23(S2):55-94,
2004; Final report12/2015 available
from CIRGlyceryl Palmitate Lactate 1 safe as cosmetic ingredients
in the practices of use andconcentration as describedin the safety assessment,provided that the content
of 1,2-diesters is nothigh enough to induceepidermal hyperplasia
IJT 26(S3):1-30,2007
Glyceryl Palmitoleate 1 IJT 23(S2):55-94,2004; Final report12/2015 available
from CIRGlyceryl Pentadecanoate 1 IJT 23(S2):55-94,
2004; Final report12/2015 available
from CIRGlyceryl Polyacrylate 1 up to 2% IJT 23(S2):55 -94,
2004Glyceryl Ricinoleate 1 IJT 26(S3) 2007;
JACT 7(6):721-39,1988 (original
report); Final report12/2015 available
from CIRGlyceryl Ricinoleate SE 1 IJT 26(S3) 2007;
Final report 12/2015available from CIR
Glyceryl Rosinate 1 IJT 23(S2):55-94,2004; Final report
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Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
12/2015 availablefrom CIR
Glyceryl Sesquioleate 1 not in current use * IJT 23(S2):55-94,2004
Glyceryl Starch 1 Final report 09/2015available from CIR
Glyceryl Stearate 1 JACT 1(4):169-92,1982; Final report12/2015 available
from CIRGlyceryl Stearate/Acetate 1 up to 7% IJT 23 (S2):55-94,
2004Glyceryl Stearate/Malate 1 Final report 12/2015
available from CIRGlyceryl Stearate/Maleate 1 not in current use * IJT 23(S2):55-94,
2004Glyceryl Stearate Citrate 1 safe as cosmetic ingredients
in the practices of use andconcentration as describedin the safety assessment,provided that the content
of 1,2-diesters is nothigh enough to induceepidermal hyperplasia
IJT 26(S3):1-30,2007
Glyceryl Stearate Diacetate 1 not in current use * IJT 20(S4):61-94,2001
Glyceryl Stearate Lactate 1 safe as cosmetic ingredientsin the practices of use andconcentration as describedin the safety assessment,provided that the content
of 1,2-diesters is nothigh enough to induceepidermal hyperplasia
IJT 26(S3):1-30,2007
Glyceryl Stearate SE 1 JACT 1(4):169-92,1982; Final report12/2015 available
from CIRGlyceryl Stearate Succinate 1 safe as cosmetic ingredients
in the practices of use andconcentration as describedin the safety assessment,provided that the content
of 1,2-diesters is nothigh enough to induceepidermal hyperplasia
IJT 26(S3):1-30,2007
Glyceryl Tallowate 1 IJT 23(S2):55-94,2004; Final report
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Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
12/2015 availablefrom CIR
Glyceryl Thioglycolate (amended) 1 safe in hair straighteners,permanent waves, tonics,dressings, etc., wave sets,other non-coloring hair
products, and hair dyes andcolors at concentrations up to15.2% (as thioglycolic acid);
hairdressers should avoid skincontact and minimize cons
IJT 28(S3):68-133,2009 JACT
10(1):135-92, 1991(original report)
Glyceryl Thiopropionate 1 not in current use * IJT 23(S2):55-94,2004
Glyceryl Triacetyl Hydroxystearate 1 9% IJT 20 (S4):61-94,2001
Glyceryl Triacetyl Ricinoleate 1 8% IJT 20 (S4):61-94,2001
Glyceryl Undecylenate 1 IJT 23 (S2):55-94,2004; Final report12/2015 available
from CIRGlycine 1 0.0005 to 4% IJT 32(S4):41-64,
2013Glycine max (soybean) polypeptide 1 Final report 09/2015
available from CIRGlycine Soja (Soybean) Oil 1 .0002 to 95% Final report 03/11
available from CIRGlycine Soja (Soybean) Oil Unsaponifiables 1 0.0001 to 0.2% Final report 03/11
available from CIRGlycine soja (soybean) peptide* 1 Final report 09/2015
available from CIRGlycine soja (soybean) protein 1 Final report 09/2015
available from CIRGlycine Soja (Soybean) Sterols 1 Final report 12/2013
available from CIRGlycol Dimethacrylate/Vinyl Alcohol Crosspolymer 1 safe in the present practices of
use and concentration whennot polymerized in benzene
Final report 11/2011available from CIR
Glycol Distearate 1 up to 9% JACT 1(2):1-11,1982 confirmed
09/01 IJT22(S1):1-35, 2003
Glycol HEMA-Methacrylate (aka Ethylene GlycolDimethacrylate )
1 safe in nail enhancementproducts when skin contact isavoided; products containing
this ingredient should beaccompanied with directions
to avoid skin contact
IJT 24(S5):53-100,2005
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Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
because of the sensitizingpotential of methacrylates
Glycolic Acid (e.g. Alpha Hydroxy Acids) 1 Glycolic and Lactic Acid,their common salts and their
simple esters, are safe foruse in cosmetic products
at concentrations less thanor equal to10%, at finalformulation pH greater
than or equal to3.5, whenformulated to avoid increasing
sun sensitivity or whendirections for use include
IJT 17(S1):1-242,1998
Glycol Ricinoleate 1 not in current use * IJT 26(S3):31-77,2007
Glycol Stearate 1 up to 6% JACT 1(2):1-11,1982 confirmed
09/01 IJT22(S1):1-35, 2003
Glycol Stearate SE 1 up to 12% JACT 1(2):1-11,1982 confirmed
09/01 IJT22(S1):1-35, 2003
Glycyrrhetinic Acid 1 up to 2% IJT 26(S2):79- 112,2007
Glycyrrhetinyl Stearate 1 not in current use * IJT 26(S2):79-112,2007
Glycyrrhiza Glabra (Licorice) Leaf Extract 1 concentration not reported* Final report 09/08available from CIR
Glycyrrhiza Glabra (Licorice) Rhizome/Root 1 0.0001 to 0.4% Final report 09/08available from CIR
Glycyrrhiza Glabra (Licorice) Root 1 0.0001 to 0.4% Final report 09/08available from CIR
Glycyrrhiza Glabra (Licorice) Root Extract 1 0.0001 to 0.4% Final report 09/08available from CIR
Glycyrrhiza Glabra (Licorice) Root Extract [polyol soluble] 1 0.0001 to 0.06% Final report 09/08available from CIR
Glycyrrhiza Glabra (Licorice) Root Juice 1 not in current use* Final report 09/08available from CIR
Glycyrrhiza Glabra (Licorice) Root Powder 1 not in current use* Final report 09/08available from CIR
Glycyrrhiza Glabra (Licorice) Root Water 1 not in current use* Final report 09/08available from CIR
Glycyrrhiza Inflata Root Extract 1 not in current use* Final report 09/08available from CIR
Glycyrrhiza Inflata Root Extract [polyol soluble] 1 0.0001 to 15% Final report 09/08available from CIR
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Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Glycyrrhiza Uralensis (Licorice) Root Extract 1 not in current use* Final report 09/08available from CIR
Glycyrrhizic Acid 1 up to 0.1% IJT 26(S2):79- 112,2007
Glyoxal (Amended) 1 1.25% in products intendedto be applied to the nail
JACT 14(5):348-63,1995 IJT
19(1):13-27, 2000Gossypium (Cotton) Seed Oil 1 IJT 20(S2):21-29,
2001Gossypium Herbaceum (Cotton) Seed Oil 1 0.004 to 32% Final report 03/11
available from CIRGrape Seed Oil PEG-8 esters 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014Guar hydroxypropyltrimonium chloride 1 0.005 to 2% IJT 34(S1): 35-65,
2015Guizotia Abyssinica Seed Oil 1 not in use at the time* Final report 03/11
available from CIRHair keratin amino acid 1 IJT 33(S4):5-12,
2014Hazel Seed Oil PEG-8 Esters 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014HC Blue No. 1 1 carcinogenicity JACT 13(5):344 -60,
1994HC Blue No. 2 1 2% in a hair dye
(diluted in use to 1%)JACT 13(5):361-73,1994; confirmed IJT30(Suppl. 2):98-99,
2011HC Orange No. 1 1 safe for use in hair
dyes up to 3%IJT 17(S4):21-38,
1998HC Red No. 1 1 0.5% JACT 15(4):320-36,
1996; confirmed06/2011
HC Red No. 3 1 safe as used in hair dyes;but should not be usedin products containingN-nitrosating agents
JACT 11(4):509-19,1992
HC Red No. 7 1 up to 1% Final Report 06/06Available from CIR
HC Yellow No. 2 1 up to 3% JACT 13(3):157-66,1994 confirmed
12/08HC Yellow No. 4 1 less than or equal to 3% IJT 17(S4):39-70,
1998HC Yellow No. 5 1 up to 1.6% IJT 26(S2):113- 124,
2007Hectorite 1 100% in a skin cleanser;
up to 15% in other usesIJT 22(S1):37-102,
2003
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Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
HEDTA 1 concentration not reported * IJT 21 (S2):95-142,2002
Helianthus Annuus (Sunflower) Seed Oil 1 0.000007 to 96% Final report 03/11available from CIR
Helianthus Annuus (Sunflower) Seed Oil Unsaponifiables 1 0.005 to 2% Final report 03/11available from CIR
HEMA 1 safe in nail enhancementproducts when skin contact isavoided; products containing
this ingredient should beaccompanied with directions
to avoid skin contactbecause of the sensitizingpotential of methacrylates
IJT 24(S5):53-100,2005
HEMA Acetoacetate 1 safe in nail enhancementproducts when skin contact isavoided; products containing
this ingredient should beaccompanied with directions
to avoid skin contactbecause of the sensitizingpotential of methacrylates
IJT 24(S5):53-100,2005
Heptyl undecylenate 1 safe as used in cosmeticswhen formulated
to be non-irritating
Final report 03/2013available from CIR
Heptylundecyl hydroxystearate 1 safe as used in cosmeticswhen formulated
to be non-irritating
Final report 03/2013available from CIR
Hexacosyl Glycol 1 not in use at the time* IJT 31 (S2): 147-168,2012
Hexadecyl D-glucoside 1 safe as used in cosmeticswhen formulated
to be non-irritating
IJT 32 (S3): 22-48,2013
Hexamidine 1 safe at concentrationsless than or equal to 0.1%
IJT 26(S3) 2007
Hexamidine Diisethionate 1 safe at concentrationsless than or equal to 0.1%
IJT 26(S3) 2007
Hexapeptide-12 1 not in current use* Final report 06/2014available from CIR
Hexyldeceth-2 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT32(S2):169-244(2012)
Hexyldeceth-20 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT32(S2):169-244(2012)
Hexyldecyl Benzoate 1 not in use at the time* IJT 31(3):342-372(2012)
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Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Hexyldecyl ethylhexanoate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Hexyldecyl hexyldecanoate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Hexyldecyl isostearate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Hexyldecyl laurate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Hexyldecyl oleate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Hexyldecyl palmitate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Hexyldecyl stearyl 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Hexyldodecyl/ octyldecyl hydroxystearate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Hexyldodecyl Salicylate 1 safe when formulated toavoid irritation and to avoidincreasing sun sensitivity,
or when increased sunsensitivity would be expected,directions for use include thedaily use of sun protection.
IJT 22(3):1-108
Hexylene Glycol 1 up to 6% JACT 4(5):223-48,1985 confirmed
02/04 IJT 25(S2),2006
Hexyl isostearate 1 safe as used in cosmeticswhen formulated
to be non-irritating
Final report 03/2013available from CIR
Hexyl laurate 1 safe as used in cosmeticswhen formulated
to be non- irritating
Final report 03/2013available from CIR
Hexyl Methacrylate 1 safe in nail enhancementproducts when skin contact isavoided; products containing
this ingredient should beaccompanied with directions
to avoid skin contactbecause of the sensitizingpotential of methacrylates
IJT 24(S5):53-100,2005
Hexyl Methicone 1 not in current use * IJT 22 (S2):11-35,2003
Hippophae Rhamnoides Fruit Oil 1 6 to 35% Final report 03/11available from CIR
Hippophae Rhamnoides Oil 1 0.2 to 0.7 Final report 03/11available from CIR
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Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Hippophae Rhamnoides Seed Oil 1 not in use at the time* Final report 03/11available from CIR
Histidine 1 0.00009 to 0.05% IJT 32(S4):41-64,2013
Histidine HCl 1 0.00003 to 0.07% IJT 32(S4):41-64,2013
Human Placental Enzymes 1 if used, should not deliverany metabolic/endocrineactivity, and they must be
free of detectable pathogenicviruses or infectious agents
IJT 21(S1):81-91,2002
Human Placental Lipids 1 if used, should not deliverany metabolic/endocrineactivity, and they must be
free of detectable pathogenicviruses or infectious agents
IJT 21(S1):81-91,2002
Human Placental Protein 1Human Umbilical Extract 1 if used, should not deliver
any metabolic/endocrineactivity, and they must be
free of detectable pathogenicviruses or infectious agents
IJT 21(S1):81-91,2002
Hyaluronic Acid 1 up to 1% IJT 28 (1): 5-67,2009
Hydrated Silica 1 up to 34% Final Report 09/09available from CIR
Hydrogenated Adansonia Digitata Oil 1 not in use at the time* Final report 03/11available from CIR
Hydrogenated Apricot Kernel Oil 1 concentration not reported* Final report 03/11available from CIR
Hydrogenated Apricot Kernel Oil Unsaponifiables 1 not in use at the time* Final report 03/11available from CIR
Hydrogenated Argania Spinosa Kernel Oil 1 not in use at the time* Final report 03/11available from CIR
Hydrogenated Avocado Oil 1 up to 5% Final report 03/11available from CIR
Hydrogenated Black Currant Seed Oil 1 not in use at the time* Final report 03/11available from CIR
Hydrogenated Butadiene/Isoprene/Styrene Copolymer 1 not in current use* Final report 09/2014available from CIR
Hydrogenated Butylene/Ethylene/Styrene Copolymer 1 Final report 09/2014available from CIR
Hydrogenated Camelina Sativa Seed Oil 1 not in use at the time* Final report 03/11available from CIR
Hydrogenated Camellia Oleifera Seed Oil 1 concentration not reported* Final report 03/11available from CIR
Hydrogenated Canola Oil 1 concentration not reported* Final report 03/11available from CIR
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Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Hydrogenated Castor Oil 1 up to 39% IJT 26 (S3):31-77,2007
Hydrogenated Castor Oil Behenyl esters 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Hydrogenated castor Oil cetyl esters 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Hydrogenated castor oil PEG-8 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Hydrogenated castor oil stearyl esters 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Hydrogenated Cocoglycerides (amended) 1 up to 31% IJT 30(S1):5S-16SHydrogenated Coconut Acid (amended) 1 6 to 10% IJT 30(S1):5S-16S;
JACT 5(3):103-21,1986 (original report)
Hydrogenated Coconut Oil (amended) 1 0.001 to 50% IJT 30(S1):5S-16S;JACT 5(3):103-21,
1986 (original report)Hydrogenated Cottonseed Glyceride 1 safe as used in cosmetic
products, provided thatestablished and imposed limits
on gossypol, heavy metals,and pesticide concentrations
are not exceeded.
IJT 20(S2):21-29,2001
Hydrogenated Cottonseed Oil 1 0.001 to 24% Final report 03/11available from CIR
Hydrogenated Cranberry Seed Oil 1 not in use at the time* Final report 03/11available from CIR
Hydrogenated Dimer Dilinoleth-20 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(3):342-372(2012)
Hydrogenated Dimer Dilinoleth-30 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(3):342-372(2012)
Hydrogenated Dimer Dilinoleth-40 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(3):342-372(2012)
Hydrogenated Dimer Dilinoleth-60 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(3):342-372(2012)
Hydrogenated Dimer Dilinoleth-80 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(3):342-372(2012)
Hydrogenated Ethylene/ Propylene/Styrene Copolymer 1 Final report 09/2014available from CIR
Hydrogenated Ethylhexyl olivate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Hydrogenated Ethylhexyl sesamate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Hydrogenated Evening Primrose Oil 1 concentration not reported* Final report 03/11available from CIR
Hydrogenated Grapeseed Oil 1 0.3 to 0.5% Final report 03/11available from CIR
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Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Hydrogenated Grapesuit Seed Oil 1 not in use at the time* Final report 03/11available from CIR
Hydrogenated Grapesuit Seed Oil Unsaponifiables 1 not in use at the time* Final report 03/11available from CIR
Hydrogenated Hazelnut Oil 1 not in use at the time* Final report 03/11available from CIR
Hydrogenated Isocetyl olivate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Hydrogenated Isopropyl Jojobate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Hydrogenated Jojoba Oil (amended) 1 up to 31% Amended FinalReport 09/08 -
available from CIRHydrogenated Kukui Nut Oil 1 not in use at the time* Final report 03/11
available from CIRHydrogenated Laneth-20 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 31(3):342-372
(2012)Hydrogenated Laneth-25 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 31(3):342-372
(2012)Hydrogenated Laneth-5 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 31(3):342-372
(2012)Hydrogenated Lanolin 1 up to 10% JEPT 4(4):63 -92,
1980 confirmed02/03 IJT
24(S1):2-10, 2005Hydrogenated Lard 1 lead 0.1ppm; arsenic 3ppm;
mercury 1ppm; total PCB/pesticide contamination40ppm with 10ppm for
any specific residue
IJT 20(S2):57-64,2001
Hydrogenated Lard Glyceride 1 lead 0.1ppm; arsenic 3ppm;mercury 1ppm; total PCB/
pesticide contamination40ppm with 10ppm for
any specific residue
IJT 20(S2):57-64,2001
Hydrogenated Lard Glycerides 1 lead 0.1ppm; arsenic 3ppm;mercury 1ppm; total PCB/
pesticide contamination40ppm with 10ppm for
any specific residue
IJT 20(S2):57-64,2001
Hydrogenated Lecithin 1 safe as used. IJT 20(S1):21-45,2001; Final report03/2015 available
from CIRHydrogenated Lime Seed Oil 1 not in use at the time* Final report 03/11
available from CIRHydrogenated Lime Seed Oil Unsaponifiables 1 not in use at the time* Final report 03/11
available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Hydrogenated Lysolecithin* 1 safe as used Final report 03/2015available from CIR
Hydrogenated Lysophosphatidylcholine* 1 safe as used Final report 03/2015available from CIR
Hydrogenated Macadamia Seed Oil 1 not in use at the time* Final report 03/11available from CIR
Hydrogenated Meadowfoam Seed Oil 1 not in use at the time* Final report 03/11available from CIR
Hydrogenated Olive Oil 1 0.0005 to 12% Final report 03/11available from CIR
Hydrogenated Olive Oil Unsaponifiables 1 0.05 to 5% Final report 03/11available from CIR
Hydrogenated Orange Seed Oil 1 not in use at the time* Final report 03/11available from CIR
Hydrogenated Orange Seed Oil Unsaponifiables 1 not in use at the time* Final report 03/11available from CIR
Hydrogenated Palm/Palm Kernel Oil PEG-6 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Hydrogenated Palm Acid 1 not in use at the time* Final report 03/11available from CIR
Hydrogenated Palm Kernel Oil 1 0.4 to 13% Final report 03/11available from CIR
Hydrogenated Palm Oil 1 0.2 to 30% IJT 19 (S2):7-28,2000; Final amended
report 03/11 availablefrom CIR
Hydrogenated Palmtrimonium chloride 1 safe when formulatedto be non- irritating
IJT 31(S3): 296-341(2012)
Hydrogenated Passiflora Edulis Seed Oil 1 not in use at the time* Final report 03/11available from CIR
Hydrogenated Peach Kernel Oil 1 not in use at the time* Final report 03/11available from CIR
Hydrogenated Peanut Oil 1 2 to 5% IJT 20 (S2):65-77,2001; final amended
report 03/11 availablefrom CIR
Hydrogenated Phosphatidylcholine* 1 safe as used Final report 03/2015available from CIR
Hydrogenated Pistachio Seed Oil 1 not in use at the time* Final report 03/11available from CIR
Hydrogenated poly(C6-12 olefin) 1 safe as used Final report 06/2015available from CIR
Hydrogenated poly(C6-14 olefin) 1 safe as used Final report 06/2015available from CIR
Hydrogenated poly(C6-20 olefin) 1 safe as used Final report 06/2015available from CIR
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Hydrogenated polybutene* 1 safe as used Final report 06/2015available from CIR
Hydrogenated polydecene 1 safe as used Final report 06/2015available from CIR
Hydrogenated polydodecene* 1 safe as used Final report 06/2015available from CIR
Hydrogenated polyisobutene 1 safe as used Final report 06/2015available from CIR
Hydrogenated Polyisobutene 1 up to 96% IJT 27 (S4): 83-106,2008
Hydrogenated Potato Starch 1 Final report 09/2015available from CIR
Hydrogenated Pumpkin Seed Oil 1 not in use at the time* Final report 03/11available from CIR
Hydrogenated Punica Granatum Seed Oil 1 not in use at the time* Final report 03/11available from CIR
Hydrogenated Rapeseed Oil 1 0.3 to 4% Final report 03/11available from CIR
Hydrogenated Raspberry Seed Oil 1 not in use at the time* Final report 03/11available from CIR
Hydrogenated Rice Bran Oil 1 not in use at the time* Final report 03/11available from CIR
Hydrogenated Rice Bran Wax 1 concentration not reported* IJT 25(S2):91-120,2006
Hydrogenated Rosa Canina Fruit Oil 1 not in use at the time* Final report 03/11available from CIR
Hydrogenated Safflower Seed Oil 1 not in use at the time* Final report 03/11available from CIR
Hydrogenated Sesame Seed Oil (amended) 1 not in current use* JACT 12(3):261-77,1993 (original
report); IJT 30 (1):40-53, 2011
Hydrogenated Shea Butter 1 up to 1% Final report 03/11available from CIR
Hydrogenated Soybean Oil 1 0.001 to 42% Final report 03/11available from CIR
Hydrogenated Starch Hydrolysate 1 Final report 09/2015available from CIR
Hydrogenated Styrene/Butadiene Copolymer 1 Final report 09/2014available from CIR
Hydrogenated Styrene/Isoprene Copolymer 1 Final report 09/2014available from CIR
Hydrogenated Sunflower Seed Oil 1 6 to 35% Final report 03/11available from CIR
Hydrogenated Sweet Almond Oil 1 up to 0.5% Final report 03/11available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Hydrogenated Sweet Almond Oil Unsaponifiables 1 not in use at the time* Final report 03/11available from CIR
Hydrogenated Tallowalkonium Bentonite* 1 safe as used when formulatedto be non-irritating
Final report 03/2016available from CIR
Hydrogenated tallowamide DEA 1 safe in the present practices ofuse and concentration when
formulated to be non-irritatingand when the levels of freeDEA do not exceed those
considered safe int the CIRsafety assessment of DEAand its salts; should not beused in cosmetic products
IJT 32(S1):36-58,2013
Hydrogenated Tallow Betaine 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2014available from CIR
Hydrogenated Talloweth-12 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(3):342-372(2012)
Hydrogenated Talloweth-25 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(3):342-372(2012)
Hydrogenated Tallow Glyceride 1 up to 25% JACT 9(2):153-64,1990 confirmed
06/06Hydrogenated Tallow Glycerides 1 up to 25% JACT 9(2):153-64,
1990 confirmed06/06
Hydrogenated Tallowtrimonium chloride 1 safe when formulatedto be non-irritating
IJT 31(S3): 296-341(2012)
Hydrogenated Vegetable Oil 1 0.0004 to 60% Final report 03/11available from CIR
Hydrogenated Wheat Germ Oil 1 not in use at the time* Final report 03/11available from CIR
Hydrogenated Wheat Germ Oil Unsaponifiables 1 not in use at the time* Final report 03/11available from CIR
Hydrolyzed Beta-glucan 1 not in current use* Final report 09/12available from CIR
Hydrolyzed caesalpinia spinosa gum 1 0.002 to 0.4% IJT 34(S1): 35-65,2015
Hydrolyzed camellia sinensis leaf 1 not in current use* Final report 09/2014available from CIR
Hydrolyzed camellia sinensis seed extract 1 Final report 09/2014available from CIR
hydrolyzed carrageenan 1 Final report 09/2015available from CIR
Hydrolyzed Cellulose Gum 1 not in use at the time* Amended safetyassessment03/09 -
Available from CIRHydrolyzed ceratonia siliqua gum extract 1 not in current use* IJT 34(S1): 35-65,
2015
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Hydrolyzed Citrus Aurantium Dulcis Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Hydrolyzed Collagen 1 up to 6% JACT 4(5)199- 221,1985 confirmed
06/04 IJT 25(S2),2006
Hydrolyzed Collagen PG-propyl dimethiconol 1 not in use at the time* Final report 03/11available from CIR
Hydrolyzed Corn Protein 1 not in use at the time* IJT 30 (S1): 17-39,2011
Hydrolyzed Corn Starch 1 not in use at the time* IJT 30 (S1): 17-39,2011
Hydrolyzed Corn Starch Hydroxyethyl Ether 1 Final report 09/2015available from CIR
Hydrolyzed Corn Starch Octenylsuccinate 1 Final report 09/2015available from CIR
Hydrolyzed Fibroin 1 Final report 12/2015available from CIR
Hydrolyzed Furcellaran 1 Final report 09/2015available from CIR
Hydrolyzed ginseng root 1 not in current use* Final report 09/12available from CIR
Hydrolyzed ginseng root extract 1 not in current use* Final report 09/12available from CIR
Hydrolyzed ginseng saponins 1 not in current use* Final report 09/12available from CIR
Hydrolyzed grape fruit 1 not in current use* Tentative report06/12 available from
CIRHydrolyzed grape skin 1 not in current use* Tentative report
06/12 available fromCIR
Hydrolyzed guar 1 0.03 to 3% IJT 34(S1): 35-65,2015
Hydrolyzed Human Placental Protein 1 if used, should not deliverany metabolic/endocrineactivity, and they must be
free of detectable pathogenicviruses or infectious agents
IJT 21(S1):81-91,2002
Hydrolyzed Jojoba Esters (amended) 1 up to 2% Amended FinalReport 09/08 -
available from CIR
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Hydrolyzed Oat Flour 1 safe when formulatedto be non- sensitizing
Final report 12/2014available from CIR
Hydrolyzed Oat Protein 1 safe when formulatedto be non- sensitizing
Final report 12/2014available from CIR
Hydrolyzed Oats 1 safe when formulatedto be non- sensitizing
Final report 12/2014available from CIR
Hydrolyzed Pectin 1 Final report 09/2015available from CIR
Hydrolyzed Phospholipids* 1 safe as used Final report 03/2015available from CIR
Hydrolyzed Placental Protein 1 if used, should not deliverany metabolic/endocrineactivity, and they must be
free of detectable pathogenicviruses or infectious agents
IJT 21(S1):81-91,2002
Hydrolyzed Rhizobian Gum 1 0.4 to 3% Final report 09/12available from CIR
Hydrolyzed Rice Bran Extract 1 up to 0.0004% These rice derivedingredients as used in
products should not containsignificant levels of pesticide
residues or heavy metals
IJT 25(S2):91-120,2006
Hydrolyzed Rice Bran Protein 1 not in current use* These rice derivedingredients as used in
products should not containsignificant levels of pesticide
residues or heavy metals
IJT 25(S2):91-120,2006
Hydrolyzed Rice Extract 1 up to 0.3% These rice derivedingredients as used in
products should not containsignificant levels of pesticide
residues or heavy metals
IJT 25(S2):91-120,2006
Hydrolyzed Rice Protein 1 up to 2% These rice derivedingredients as used in
products should not containsignificant levels of pesticide
residues or heavy metals
IJT 25(S2):91-120,2006
Hydrolyzed Sclerotium gum 1 1% Final report 09/12available from CIR
Hydrolyzed Sericin 1 Final report 12/2015available from CIR
Hydrolyzed Silk 1 Final report 12/2015available from CIR
Hydrolyzed soymilk protein 1 Final report 09/2015available from CIR
Hydrolyzed soy protein 1 Final report 09/2015available from CIR
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Hydrolyzed soy protein extract 1 Final report 09/2015available from CIR
Hydrolyzed Soy Starch 1 Final report 09/2015available from CIR
Hydrolyzed Starch 1 Final report 09/2015available from CIR
Hydrolyzed Triticum Spelta Starch 1 Final report 09/2015available from CIR
Hydrolyzed Wheat Gluten 1 safe as used in cosmeticswhen formulated to restrict
peptides to a weight-averagemolecular weight (MW) of3,500 daltons (Da) or less.
Final report 06/2014available from CIR
Hydrolyzed Wheat Protein 1 safe as used in cosmeticswhen formulated to restrict
peptides to a weight-averagemolecular weight (MW) of3,500 daltons (Da) or less.
Final report 06/2014available from CIR
Hydrolyzed Wheat Starch 1 Final report 09/2015available from CIR
Hydroquinone 1 1 safe at concentrations ofless than or equal to 1%
for cosmetic formulationsdesigned for discontinuous,
brief use followed byrinsing from the skin and
hair. Hydroquinone is safefor use in nail adhesives
and in artificial nailcoatings, as a polymeriza
Unsafe for use in otherleave-on cosmetic products
JACT 5(3):123-65,1986; JACT
13(3):167-230, 1994;IJT 29 (S4): 274-287,
2010; Final report12/2014 available
from CIR
Hydroxybenzomorpholine 1 0.03% JACT 10(1):205- 13,1991
Hydroxybutyl Methylcellulose 1 not in use at the time* Amended safetyassessment 03/09 -
Available from CIRhydroxycaproyl phytosphingosine* 1 safe as used Final report 03/2015
available from CIRhydroxycapryloyl phytosphingosine* 1 safe as used Final report 03/2015
available from CIRHydroxycetyl isostearate 1 not in current use* safe as used in cosmetics
when formulatedto be non-irritating
Final report 03/2013available from CIR
Hydroxyethylcellulose (amended) 1 up to 6% Amended safetyassessment 03/09 -
Available from CIRJACT 5(3):1-59,
1986 (original report)
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Hydroxyethyl Cyclodextrin 1 Final report 09/2015available from CIR
Hydroxyethyl Ethylcellulose (amended) 1 up to 3% Amended safetyassessment 03/09 -
Available from CIRHydroxyethylmethacrylate Acetoacetate 1 safe in nail enhancement
products when skin contact isavoided; products containing
this ingredient should beaccompanied with directions
to avoid skin contactbecause of the sensitizingpotential of methacrylates
IJT 24(S5):53-100,2005
Hydroxylated Lanolin 1 up to 28% JEPT 4(4):63- 92,1980 confirmed
02/03 IJT24(S1):2-10, 2005
hydroxylauroyl phytosphingosine* 1 safe as used Final report 03/2015available from CIR
Hydroxyoctacosanyl Hydroxystearate ` safe as used in cosmeticswhen formulated
to be non-irritating
Final report 03/2013available from CIR
hydroxypalmitoyl sphinganine 1 safe as used Final report 03/2015available from CIR
Hydroxypropyl Bis(N-Hydroxyethyl-p-Phenylenediamine)HCl
1 Final report 09/2013available from CIR
Hydroxypropylcellulose (amended) 1 up to 4% Amended safetyassessment 03/09 -
Available from CIRJACT 5(3):1-59,
1986 (original report)Hydroxypropyl Cyclodextrin 1 Final report 09/2015
available from CIRHydroxypropyldimethicone 1 not in current use* IJT 22(S2):11-35,
2003Hydroxypropyl dimethicone/polysorbate 20 crosspolymer 1 not in current use* Final report 09/12
available from CIRHydroxypropyl guar 1 0.05 to 2% in leave-on;
0.1 to 93% in rinse- offIJT 34(S1): 35-65,
2015Hydroxypropyl guar hydroxypropyltrimonium chloride 1 0.04 to 0.9% IJT 34(S1): 35-65,
2015Hydroxypropyl Methacrylate 1 safe in nail enhancement
products when skin contact isavoided; products containing
this ingredient should beaccompanied with directions
to avoid skin contact
IJT 24(S5):53-100,2005
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
because of the sensitizingpotential of methacrylates
Hydroxypropyl Methylcellulose (amended) 1 up to 4% Amended safetyassessment 03/09 -
Available from CIR;JACT 5(3):1-59,
1986 (original report)Hydroxypropyl Methylcellulose Acetate/Succinate 1 not in use at the time* Amended Safety
Assessment 03/09available from CIR
Hydroxypropyl Oxidized Starch 1 Final report 09/2015available from CIR
Hydroxypropyl Starch 1 Final report 09/2015available from CIR
Hydroxypropyltrimonium Hydrolyzed Corn Starch 1 Final report 09/2015available from CIR
Hydroxypropyltrimonium Hydrolyzed Wheat Starch 1 Final report 09/2015available from CIR
Hydroxypropyltrimonium Maltodextrin Crosspolymer 1 Final report 09/2015available from CIR
Hydroxypropyl xanthan gum 1 not in current use* Final report 09/12available from CIR
Hydroxystearamide MEA 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
IJT 34(S1): 18-34,2015
Hydroxystearic Acid 1 up to 10% IJT 18(S1):1- 10,1999
Hypericum Perforatum Extract 1 IJT 20(S2):31-39,2001; IJT
33(S3):5-23, 2014Hypericum Perforatum Flower/Leaf/Stem Extract 1 IJT 33(S3):5-23,
2014Hypericum Perforatum Flower/Leaf Extract 1 not in current use* IJT 33(S3):5-23,
2014Hypericum Perforatum Flower/Twig Extract 1 not in current use* IJT 33(S3):5-23,
2014Hypericum Perforatum Flower Extract 1 IJT 33(S3):5-23,
2014Hypericum Perforatum Leaf Extract 1 not in current use* IJT 33(S3):5-23,
2014Hypericum Perforatum Oil 1 IJT 20(S2):31-39,
2001; IJT33(S3):5-23, 2014
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Imidazolidinyl Urea 1 up to 1% JEPT 4(4):133- 46,1980 confirmed
09/01 IJT22(S1):1-35, 2003
Inulin 1 Final report 09/2015available from CIR
Iodopropynyl Butylcarbamate (IPBC) 1 safe for use at 0.1%; shouldnot be used in products
intended to be aerosolized
IJT 17(S5):1-37,1998
Irvingia Gabonensis Kernel Butter 1 0.003 to 0.4% Final report 03/11available from CIR
Isoamyl Acetate 1 up to 10% JACT 7(6):705-19,1988
Isoamyl Laurate 1 safe as used in cosmeticswhen formulated
to be non-irritating
Final report 03/2013available from CIR
Isobornyl Methacrylate 1 safe in nail enhancementproducts when skin contact isavoided; products containing
this ingredient should beaccompanied with directions
to avoid skin contactbecause of the sensitizingpotential of methacrylates
IJT 24(S5):53-100,2005
Isobutane 1 up to 85% JACT 1(4):127-42,1982 confirmed
06/02 IJT24(S1):52-55, 2005
Isobutyl Acetate 1 6 to 45% IJT 31(S1):112-136,2012
Isobutyl Benzoate 1 0.01% IJT 31(3):342-372(2012)
Isobutylene/isoprene copolymer* 1 safe as used Final report 06/2015available from CIR
Isobutylene/styrene copolymer 1 Final report 09/2014available from CIR
Isobutyl Methacrylate 1 safe in nail enhancementproducts when skin contact isavoided; products containing
this ingredient should beaccompanied with directions
to avoid skin contactbecause of the sensitizingpotential of methacrylates
IJT 24(S5):53-100,2005
Isobutyl Myristate 1 not in current use* safe as used in cosmeticswhen formulated
to be non-irritating
IJT29(S3) :162-186,2010;
final report 03/2013available from CIR
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Isobutyl Palmitate 1 not in current use* safe as used in cosmeticswhen formulated
to be non-irritating
final report 03/2013available from CIR
Isobutylparaben 1 up to 0.4% if used alone;parabens mixture up to 0.8%
IJT 27(S4):1-82, 2008
JACT14(5):364-372,1995 (original report)
Isobutyl Pelargonate 1 not in current use* safe as used in cosmeticswhen formulated
to be non-irritating
Final report 06/10available from CIR;final report 03/2013available from CIR
Isobutyl Stearate 1 not in current use* safe as used in cosmeticswhen formulated
to be non-irritating
JACT 4(5):107-46,1985 confirmed
06/03 IJT24(S1):21-25, 2005;final report 03/2013available from CIR
Isobutyl Tallowate 1 not in current use* safe as used in cosmeticswhen formulated
to be non-irritating
final report 03/2013available from CIR
Isoceteth-10 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244,2012
Isoceteth-12 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244,2012
Isoceteth-15 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244,2012
Isoceteth-20 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244,2012
Isoceteth-25 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244,2012
Isoceteth-30 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244,2012
Isoceteth-5 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244,2012
Isoceteth-7 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244,2012
Isocetyl Behenate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Isocetyl ethylhexanoate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Isocetyl Isodecanoate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Isocetyl Isostearate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Isocetyl Laurate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Isocetyl Myristate 1 concentration not reported* safe for use in cosmetics whenformulated to be non-irritating
IJT29(S3) :162-186,2010;
final report 03/2013available from CIR
Isocetyl Palmitate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Isocetyl Salicylate 1 safe when formulated toavoid irritation and to avoidincreasing sun sensitivity,
or when increased sunsensitivity would be expected,directions for use include thedaily use of sun protection.
IJT 22(3):1-108
Isocetyl Stearate 1 up to 30% safe for use in cosmetics whenformulated to be non-irritating
JACT 4(5):107-46,1985 confirmed
06/03 IJT24(S1):21-25, 2005;final report 03/2013available from CIR
Isodeceth-4 1 safe for use in cosmeticswhen formulated
to be non- irritating
Final report 12/10available from CIR
Isodeceth-5 1 safe for use in cosmeticswhen formulated
to be non- irritating
Final report 12/10available from CIR
Isodeceth-6 1 safe for use in cosmeticswhen formulated
to be non- irritating
Final report 12/10available from CIR
Isodecyl citrate 1 concentration not reported* IJT 33 (S2): 16-46,2014
Isodecyl Cocoate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
IJT 30(S1):5S-16S;final report 03/2013available from CIR
Isodecyl ethylhexanoate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Isodecyl glyceryl ether 1 not in current use* IJT 32 (S3): 5-21,2013
Isodecyl Hydroxystearate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Isodecyl isononanoate 1 up to 59% safe for use in cosmetics whenformulated to be non-irritating
IJT 30(S3):228-269,2011; final report
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
03/2013 availablefrom CIR
Isodecyl laurate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Isodecyl Myristate 1 concentration not reported* safe for use in cosmetics whenformulated to be non-irritating
IJT29(S3) :162-186,2010;
final report 03/2013available from CIR
Isodecyl Neopentanoate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Isodecyl Oleate 1 up to 8% safe for use in cosmetics whenformulated to be non-irritating
JACT 1(2):85-95,1982 confirmed
11/01 IJT22(S1):1-35, 2003;
final report 03/2013available from CIR
Isodecyl Palmitate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Isodecyl Salicylate 1 safe when formulated toavoid irritation and to avoidincreasing sun sensitivity,
or when increased sunsensitivity would be expected,directions for use include thedaily use of sun protection.
IJT 22(3):1-108
Isodecyl Stearate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Isododecane 1 safe when formulatedto be non- irritating
IJT 31(S3): 269-295(2012)
Isoeicosane 1 safe when formulatedto be non- irritating
IJT 31(S3): 269-295(2012)
Isohexadecane 1 safe when formulatedto be non- irritating
IJT 31(S3): 269-295(2012)
Isohexyl Caprate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Isohexyl Laurate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Isohexyl Neopentanoate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Isohexyl Palmitate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Isolaureth-10 1 safe when formulatedto be non- irritating
IJT 31(S2):169-244(2012)
Isolaureth-3 1 safe when formulatedto be non- irritating
IJT 31(S2):169-244(2012)
Isolaureth-6 1 safe when formulatedto be non- irritating
IJT 31(S2):169-244(2012)
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Isolauryl Behenate 1 safe for use in cosmetics whenformulated to be non-irritating
final report 03/2013available from CIR
Isoleucine 1 0.0003 to 0.002% IJT 32(S4):41-64,2013
Isomalt 1 Final report 03/2014available from CIR
Isomerized Jojoba Oil (amended) 1 not in current use* Amended FinalReport 09/08 -
available from CIRIsomyreth-3 1 safe when formulated
to be non- irritatingIJT 31(S2):169-244
(2012)Isomyreth-9 1 safe when formulated
to be non- irritatingIJT 31(S2):169-244
(2012)Isononyl isononanoate 1 up to 64% IJT 30 (S3):228-269,
2011; final report03/2013 available
from CIRIsooctane 1 safe when formulated
to be non- irritatingIJT 31(S3): 269-295
(2012)Isooctyl Caprylate/Caprate 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIRIsooctyl Tallate 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIRIsooctyl Thioglycolate 1 safe in hair straighteners,
permanent waves, tonics,dressings, etc., wave sets,other non-coloring hair
products, and hair dyes andcolors at concentrations up to15.2% (as thioglycolic acid);
hairdressers should avoid skincontact and minimize cons
IJT 28(S3):68-133,2009
Isopentane 1 up to 37% JACT 1(4):127-42,1982 confirmed
06/02 IJT24(S1):52-55, 2005
Isopolyglyceryl-3 dimethiconol 1 not in current use* Final report 12/10available from CIR
Isoprene/pentadiene copolymer* 1 safe as used Final report 06/2015available from CIR
Isopropanolamine 1 safe for use in cosmeticproducts; but should not beused in products containing
N-nitrosating agents
JACT 6(1):53-76,1987 confirmed
12/04 IJT 25(S2),2006
Isopropyl Acetate 1 0.5 to 2% IJT 31(S1):112- 136,2012
Isopropyl Alcohol 1 0.002 to 100% (100% inmanicuring preparations)
IJT 31(S1):112-136,2012
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Isopropylamine Dodecylbenzenesulfonate (amended) 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 29 (S4) 288-305,2010
Isopropyl Arachidate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Isopropyl Avocadate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Isopropyl Babassuate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Isopropyl Behenate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Isopropyl Benzoate 1 IJT 31(3):342-372(2012)
Isopropyl citrate 1 not in current use* IJT 33 (S2): 16-46,2014
Isopropyl Cresols 1 up to 5% IJT 25(S1):29-127,2006 (Amended
Report)Isopropyl Ester of PVM/MA Copolymer (amended) 1 not in current use* Amended Final
Report 06/09Available from CIRJACT 12(3):243-56,
1993 (original report)Isopropyl Hydroxystearate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIRIsopropylidenediphenyl Bisglycidyl Methacrylate 1 safe in nail enhancement
products when skin contact isavoided; products containing
this ingredient should beaccompanied with directions
to avoid skin contactbecause of the sensitizingpotential of methacrylates
IJT 24(S5):53-100,2005
Isopropyl Isostearate 1 up to 65% safe for use in cosmetics whenformulated to be non-irritating
JACT 11(1):43-9,1992; final report03/2013 available
from CIRIsopropyl Jojobate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIRIsopropyl Lactate 1 Glycolic and Lactic Acid,
their common salts and theirsimple esters, are safe foruse in cosmetic products
at concentrations less thanor equal to10%, at finalformulation pH greater
than or equal to3.5, whenformulated to avoid increasing
IJT 17(S1):1-242,1998
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
sun sensitivity or whendirections for use include
Isopropyl Lanolate 1 up to 26% JEPT 4(4):121- 32,1980 confirmed
06/01 IJT22(S1):1-35, 2003
Isopropyl Laurate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Isopropyl Linoleate 1 safe for use in cosmetics whenformulated to be non-irritating
JACT 11(1):51-56,1992; final report03/2013 available
from CIRIsopropyl Myristate 1 up to 82% safe for use in cosmetics when
formulated to be non-irritatingJACT 1(4):55-80,
1982 confirmed06/02 IJT
24(S1):63-67, 2005;final report 03/2013available from CIR
Isopropyl Oleate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Isopropyl Palmitate 1 up to 44% safe for use in cosmetics whenformulated to be non-irritating
JACT 1(2):13-35,1982 confirmed
09/01 IJT24(S1):28-32, 2005;final report 03/2013available from CIR
Isopropylparaben 1 up to 0.4% if used alone;parabens mixture up to 0.8%
IJT 27(S4):1-82, 2008
JACT14(5):364-372,1995 (original report)
Isopropyl Ricinoleate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
IJT 26(S3) 2007;final report 03/2013available from CIR
Isopropyl Stearate 1 up to 87% safe for use in cosmetics whenformulated to be non-irritating
JACT 4(5):107-146,1985 confirmed
06/03 IJT24(S1):21-25, 2005;final report 03/2013available from CIR
Isopropyl Tallowate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Isopropyl Thioglycolate 1 in hair straighteners,permanent waves, tonics,dressings, etc., wave sets,other non-coloring hairproducts, and hair dyes
and colors; safe at 15.2%(as thioglycolic acid);
IJT 28(S3):68-133,2009
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
hairdressers should avoidskin contact and minimizeconsumer skin exposure
isopropyl titanium triisostearate/triethoxysilylethylpolydimethylsiloxyethyl dimethicone crosspolymer
1 concentration not reported* Final report 09/12available from CIR
Isostearamide DEA (amended) 1 safe in the present practices ofuse and concentration when
formulated to be non-irritatingand when the levels of freeDEA do not exceed those
considered safe int the CIRsafety assessment of DEAand its salts; should not beused in cosmetic products
IJT 32(S1):36-58,2013
Isostearamide MEA (amended) 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
IJT 34(S1): 18-34,2015
Isostearamidopropyl Betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
IJT 31(S1):77-111,2012
Isostearamidopropyl Dimethylamine 1 safe in cosmetics as longas they are formulatedto be non-sensitizing,
which may be based on aquantitative risk assessment
Final report 06/2014available from CIR
Isostearamidopropyl Morpholine Lactate 1 safe for use in rinse-off products; data are
insufficient to support safetyin leave-on formulations
IJT 18(S3):51-56,1999
Isosteareth-10 1 safe when formulatedto be non- irritating
IJT 31(S2):169-244(2012)
Isosteareth-12 1 safe when formulatedto be non- irritating
IJT 31(S2):169-244(2012)
Isosteareth-15 1 safe when formulatedto be non- irritating
IJT 31(S2):169-244(2012)
Isosteareth-16 1 safe when formulatedto be non- irritating
IJT 31(S2):169-244(2012)
Isosteareth-2 1 safe when formulatedto be non- irritating
IJT 31(S2):169-244(2012)
Isosteareth-20 1 safe when formulatedto be non- irritating
IJT 31(S2):169-244(2012)
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Isosteareth-22 1 safe when formulatedto be non- irritating
IJT 31(S2):169-244(2012)
Isosteareth-25 1 safe when formulatedto be non- irritating
IJT 31(S2):169-244(2012)
Isosteareth-3 1 safe when formulatedto be non- irritating
IJT 31(S2):169-244(2012)
Isosteareth-5 1 safe when formulatedto be non- irritating
IJT 31(S2):169-244(2012)
Isosteareth-50 1 safe when formulatedto be non- irritating
IJT 31(S2):169-244(2012)
Isosteareth-8 1 safe when formulatedto be non- irritating
IJT 31(S2):169-244(2012)
Isostearic Acid 1 up to 26% JACT 2(7):61-74,1983 confirmed
09/02 IJT24(S1):55-56, 2005
Isostearyl Acetate 1 0.002 to 5% IJT 31 (S1):112-136,2012
Isostearyl Alcohol 1 up to 50% JACT 7(3):359-413, 1988 confirmed
12/05Isostearyl Avocadate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIRIsostearyl Behenate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIRIsostearyl Benzoate 1 1% IJT 31(3):342-372
(2012)Isostearyl Erucate 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIRIsostearyl Ethylhexanoate 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIRIsostearyl glucoside 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 32 (S3): 22-48,
2013Isostearyl Glyceryl Ether 1 0.001 to 0.02% IJT 32 (S3): 5-21,
2013Isostearyl Hydroxystearate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIRIsostearyl Isononanoate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIRIsostearyl Isostearate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIRIsostearyl Laurate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIRIsostearyl Linoleate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIRIsostearyl Myristate 1 not in use at the time* safe for use in cosmetics when
formulated to be non-irritatingIJT
29(S3) :162-186,2010;
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
final report 03/2013available from CIR
Isostearyl Neopentanoate 1 up to 14% safe for use in cosmetics whenformulated to be non-irritating
JACT 4(3):1-22,1985 confirmed
09/03 IJT 25(S2),2006; final report03/2013 available
from CIRIsostearyl palmitate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIRIsostearyl sebacate 1 up to 0.7% IJT 31(S1):5- 76,
2012Isotridecyl isononanoate 1 up to 51% safe for use in cosmetics when
formulated to be non-irritatingIJT 30(S3):228-269,
2011; final report03/2013 available
from CIRIsotridecyl Laurate 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIRIsotridecyl Myristate 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingIJT
29(S3) :162-186,2010;final report 03/2013available from CIR
Isotridecyl Stearate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Japan (Rhus Succedanea) Wax 1 up to 34% JACT 3 (3):1-41,1984 confirmed
06/03Jojoba Alcohol (amended) 1 up to 1% Amended Final
Report 09/08 -available from CIR
Jojoba Amino Acids 1 not in current use* IJT 33(S4):5-12,2014
Jojoba Esters (amended) 1 up to 44% Amended FinalReport 09/08 -
available from CIRJojoba oil PEG-150 esters 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014Jojoba oil PEG-8 esters 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014Juglans Regia (Walnut) Seed Oil 1 0.00003 to 0.2% Final report 03/11
available from CIRJuniperus Communis Fruit Extract 1 IJT 20(S2):41- 56,
2001Juniperus Oxycedrus Fruit Extract 1 IJT 20(S2):41-56,
2001Juniperus Oxycedrus Tar 1 IJT 20(S2):41-56,
2001
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Juniperus Phoenicea Gum Extract 1 IJT 20(S2):41-56,2001
Juniperus Virginiana Wood Extract 1 IJT 20(S2):41 -56,2001
Kaolin 1 up to 100% IJT 22(S1):37-102,2003
Kefiran 1 Final report 03/2014available from CIR
Keratin Amino Acids 1 IJT 33(S4):5-12,2014
Kojic Acid 1 up to 1% IJT 29 (S4): 244-273,2010
Lactamide MEA 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
IJT 34(S1): 18-34,2015
Lactic Acid 1 safe for use in cosmeticproducts at concentrationsless than or equal to10%,at final formulation pH
greater than or equal to3.5,when formulated to avoidincreasing sun sensitivityor when directions for use
include the daily use of sunprotection. These ingredients
are safe for use in sal
IJT 17(S1):1-242,1998
Lactitol 1 Final report 03/2014available from CIR
Lactose 1 Final report 03/2014available from CIR
Lactulose 1 not in current use * Final report 03/2014available from CIR
Laneth-10 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laneth-10 Acetate 1 not in current use * JACT 1(4):1-23,1982 confirmed
02/02 IJT24(S1):56-59, 2005
Laneth-15 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Laneth-16 1 up to 2% safe for use in cosmetics whenformulated to be non-irritating
JACT 1(4):1-23,1982 confirmed
02/02 IJT24(S1):56-59,
2005;IJT31(S2):169-244
(2012)Laneth-20 1 safe for use in cosmetics
when formulatedto be non- irritating
IJT 31(S2):169-244(2012)
Laneth-25 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laneth-40 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laneth-5 1 up to 2% safe for use in cosmetics whenformulated to be non-irritating
JACT 1(4):1-23,1982 confirmed
02/02 IJT24(S1):56-59, 2005;IJT 31(S2):169-244
(2012)Laneth-50 1 safe for use in cosmetics
when formulatedto be non- irritating
IJT 31(S2):169-244(2012)
Laneth-60 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laneth-75 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laneth-9 Acetate 1 not in current use * JACT 1 (4):1-23,1982 confirmed
02/02 IJT24(S1):56-59, 2005
Lanolin 1 up to 37% JEPT 4(4):63-92,1980 confirmed
02/03 IJT24(S1):2-10, 2005
Lanolin Acid 1 up to 10% JEPT 4(4):63-92,1980 confirmed
02/03 IJT24(S1):2-10, 2005
Lanolin Alcohol 1 up to 4% JEPT 4(4):63 -92,1980 confirmed
02/03 IJT24(S1):2-10, 2005
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Lanolinamide DEA 1 safe in the present practices ofuse and concentration when
formulated to be non-irritatingand when the levels of freeDEA do not exceed those
considered safe int the CIRsafety assessment of DEAand its salts; should not beused in cosmetic products
IJT 32(S1):36-58,2013
Lanolin Oil 1 up to 65% JEPT 4(4):63-92,1980 confirmed
02/03 IJT24(S1):2-10, 2005
Lanolin Wax 1 up to 25% JEPT 4(4):63-92,1980 confirmed
02/03 IJT24(S1):2-10, 2005
Lapyrium Chloride 1 0.03% in a body wash JACT 10(1):87-97,1991
Lard 1 lead 0.1ppm; arsenic 3ppm;mercury 1ppm; total PCB/
pesticide contamination40ppm with 10ppm for
any specific residue
IJT 20(S2):57-64,2001
Lard Glyceride 1 lead 0.1ppm; arsenic 3ppm;mercury 1ppm; total PCB/
pesticide contamination40ppm with 10ppm for
any specific residue
IJT 20(S2):57-64,2001
Lard Glycerides 1 lead 0.1ppm; arsenic 3ppm;mercury 1ppm; total PCB/
pesticide contamination40ppm with 10ppm for
any specific residue
IJT 20(S2):57-64,2001
L-Ascorbic Acid 1 up to 10% IJT 24(2):51-111,2005
Lauramide/Myristamide DEA 1 safe in the present practices ofuse and concentration when
formulated to be non-irritatingand when the levels of freeDEA do not exceed those
considered safe int the CIRsafety assessment of DEAand its salts; should not beused in cosmetic products
IJT 32(S1):36-58,2013
Lauramide DEA (amended) 1 safe in the present practices ofuse and concentration when
formulated to be non-irritatingand when the levels of free
JACT 5(5):415-54,1986 (originalreport); IJT 32
(S1):36-58, 2013
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
DEA do not exceed thoseconsidered safe int the CIRsafety assessment of DEAand its salts; should not beused in cosmetic products
Lauramide MEA 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
IJT 34(S1): 18-34,2015
Lauramidopropyl betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
IJT 31(S1):77-111,2012
Lauramidopropyl dimethylamine 1 safe in cosmetics as longas they are formulatedto be non-sensitizing,
which may be based on aquantitative risk assessment
Final report 06/2014available from CIR
Lauramine 1 JACT 14(3):196-203,1995
Lauramine Oxide 1 safe for use in rinse-off products; but 3.7%for leave-on products
JACT 13(3):231-45,1994 confirmed
09/09; IJT30(S2):73-127, 2011
Laurdimonium Hydroxypropyl Hydrolyzed Wheat Starch 1 Final report 09/2015available from CIR
Laureth-1 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laureth-10 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laureth-11 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laureth-12 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laureth-13 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Laureth-14 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laureth-15 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laureth-16 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laureth-2 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laureth-20 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laureth-21 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laureth-23 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laureth-25 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laureth-3 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laureth-30 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laureth-38 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laureth-4 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laureth-40 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laureth-5 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laureth-50 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laureth-6 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Laureth-7 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laureth-8 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laureth-9 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Lauric Acid 1 up to 25% JACT 6(3):321-401,1987 confirmed
06/05 IJT 25(S2),2006
Lauriminodipropionic Acid 1 not in use at the time* Final amended report12/11
Lauroyl arginine 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Lauroyl collagen amino acids 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Lauroyl Ethyltrimonium methosulfate 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S3): 296-341(2012)
Lauroyl glutamic acid 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Lauroyl lysine 1 safe for use in cosmeticswhen formulated
to be non- irritating
Final report 12/2013available from CIR
Lauroyl proline 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Lauroyl Sarcosine 1 safe as used in rinse-offproducts; but 5% in leave-on products. Should not beused in products where N-nitroso compounds may beformed. Insufficient data todetermine safety in products
where these ingredientsare likely to be inhaled.
IJT 20(S1):1-14,2001
Lauroyl silk amino acids 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Laurtrimonium bromide 1 safe for use when formulatedto be non- irritating
IJT 31(S3): 296-341(2012)
Laurtrimonium chloride 1 safe for use when formulatedto be non- irritating
IJT 31(S3): 296-341(2012)
Lauryl/Myristyl Benzoate 1 not in use at the time* IJT 31(3):342-372(2012)
Lauryl Acrylate/VA Copolymer 1 safe for use whenformulated to avoid irritation
IJT 21(S3):1-50,2002
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Lauryl Behenate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Lauryl betaine 1 0.015-8.8% safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2014available from CIR
Lauryl Cocoate (amended) 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
IJT 30(S1):5S-16S;final report 03/2013available from CIR
Lauryl dimethicone/polyglycerin-3 crosspolymer 1 2% Final report 09/12available from CIR
Lauryl dimethicone PEG-15 crosspolymer 1 not in current use* Final report 09/12available from CIR
Lauryl ethylhexanoate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Lauryl Glucoside 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 32 (S3): 22-48,2013
Lauryl Glycol 1 not in use at the time* IJT 31 (S2): 147-168,2012
Lauryl Isopentyl-PEG/PPG-18/18 Methicone* 1 Final report 12/2014available from CIR
Lauryl Isostearate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Lauryl Lactate 1 IJT 17(S1):1-242,1998
Lauryl Laurate 1 safe for use in cosmeticswhen formulated
to be non- irritating
Final report 03/2013available from CIR
Lauryl Methacrylate 1 safe in nail enhancementproducts when skin contact isavoided; products containing
this ingredient should beaccompanied with directions
to avoid skin contactbecause of the sensitizingpotential of methacrylates
IJT 24(S5):53-100,2005
Lauryl Methacrylate/Glycol Dimethacrylate Crosspolymer 1 safe in the present practices ofuse and concentration whennot polymerized in benzene
Final report 11/2011available from CIR
Lauryl Methacrylate/Sodium Methacrylate Crosspolymer 1 safe in the present practices ofuse and concentration whennot polymerized in benzene
Final report 11/2011available from CIR
Lauryl Myristate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
IJT29(S3) :162-186,2010;
final report 03/2013available from CIR
Lauryl Oleate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Lauryl Palmitate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Lauryl PEG/PPG-18/18 Methicone 1 Final report 12/2014available from CIR
Lauryl PEG-10 Methyl Ether Dimethicone* 1 Final report 12/2014available from CIR
Lauryl PEG-10 Tris(trimethylsiloxy)silylethyl Dimethicone* 1 Final report 12/2014available from CIR
Lauryl PEG-8 Dimethicone 1 Final report 12/2014available from CIR
Lauryl PEG-8 PPG-8 Dimethicone* 1 Final report 12/2014available from CIR
Lauryl PEG-9 Polydimethylsiloxyethyl Dimethicone 1 Final report 12/2014available from CIR
Lauryl Phosphate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2014available from CIR
Lauryl polydimethylsiloxyethyl dimethicone/bis-vinyldimethicone crosspolymer
1 not in current use* Final report 09/12available from CIR
Lauryl Polyglyceryl-3 PolydimethylsiloxyethylDimethicone*
1 Final report 12/2014available from CIR
Lauryl Stearate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Lecithin 1 safe as used. IJT 20(S1):21-45,2001; Final report03/2015 available
from CIRLecithinamide DEA 1 safe in the present practices of
use and concentration whenformulated to be non-irritating
and when the levels of freeDEA do not exceed those
considered safe int the CIRsafety assessment of DEAand its salts; should not beused in cosmetic products
IJT 32(S1):36-58,2013
Leucine 1 0.0009 to 0.001% IJT 32(S4):41-64,2013
Levan 1 not in current use* Final report 09/12available from CIR
Lignoceryl Erucate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Limnanthes Alba (Meadowfoam) Seed Oil 1 0.002 to 74% Final report 03/11available from CIR
Linoleamide DEA (amended) 1 safe in the present practices ofuse and concentration when
formulated to be non-irritatingand when the levels of freeDEA do not exceed those
considered safe int the CIRsafety assessment of DEA
JACT 5(5):415-454,1986 (originalreport); IJT 32
(S1):36-58, 2013
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
and its salts; should not beused in cosmetic products
Linoleamide MEA 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
IJT 34(S1): 18-34,2015
Linoleamidopropyl dimethylamine 1 safe in cosmetics as longas they are formulatedto be non-sensitizing,
which may be based on aquantitative risk assessment
Final report 06/2014available from CIR
Linseed Acid 1 concentration not reported* Final report 03/11available from CIR
Linseed oil PEG-8 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Linum Usitatissimum (Linseed) Oil 1 0.001 to 10% Final report 03/11available from CIR
Lithium Magnesium Silicate 1 not in current use* IJT 22(S1):37-102,2003
Lithium Magnesium Sodium Silicate 1 not in current use* IJT 22(S1):37-102,2003
Lithium Stearate 1 up to 3% JACT 1(2):143-177,1982 confirmed
11/01 IJT22(S1):1-35, 2003
Locust bean hydroxypropyltrimonium chloride 1 0.4% in rinse- off IJT 34(S1): 35-65,2015
Luffa Cylindrica Seed Oil 1 up to 0.01% Final report 03/11available from CIR
Lupine amino acids 1 IJT 33(S4):5-12,2014
Lupinus Albus Oil Unsaponifiables 1 not in use at the time* Final report 03/11available from CIR
Lupinus Albus Seed Oil 1 concentration not reported* Final report 03/11available from CIR
Lycium Barbarum Amino Acids 1 not in current use* IJT 33(S4):5-12,2014
Lycium Barbarum Seed Oil 1 concentration not reported* Final report 03/11available from CIR
Lysine 1 1.0 x 10-7 to 0.7% IJT 32(S4):41-64,2013
Lysine HCl 1 0.00003 to 0.6% IJT 32(S4):41-64,2013
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Lysolecithin 1 safe as used Final report 03/2015available from CIR
Lysophosphatidic Acid 1 safe as used Final report 03/2015available from CIR
Lysophosphatidylethanolamine* 1 safe as used Final report 03/2015available from CIR
Lysophosphatidylglycerol* 1 safe as used Final report 03/2015available from CIR
Macadamia Integrifolia Seed Oil 1 0.00006 to 5% Final report 03/11available from CIR
Macadamia Ternifolia Seed Oil 1 0.0003 to 30% Final report 03/11available from CIR
Macadamia ternifolia seed oil PEG-8 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Magnesium/TEA-Coco-Sulfate 1 not in current use* safe as used when formulatedto be non-irritating.
These ingredients shouldnot be used in cosmetic
products in which N-nitrosocompounds can be formed.
IJT 32(S1):59-83,2013
Magnesium Acetate 1 0.02 to 0.03% IJT 31 (S1):112-136,2012
Magnesium Alginate 1 Final report 09/2015available from CIR
Magnesium Aluminum Silicate 1 up to 5% IJT 22 (S1):37-102,2003
Magnesium Ascorbate 1 not in current use* IJT 24(2):51-111,2005
Magnesium Ascorbyl Phosphate 1 up to 3% IJT 24(2):51-111,2005
Magnesium Aspartate 1 0.00005 to 0.1% IJT 32(S4):41-64,2013
Magnesium Benzoate 1 not in use at the time* Final amended report10/11 available from
CIRMagnesium citrate 1 0.01 to 2% IJT 33 (S2): 16 -46,
2014Magnesium Coceth Sulfate 1 safe in the present practices of
use and concentration whenformulated to be non-irritating
IJT29(S3) :151-161,2010
Magnesium Cocoate (amended) 1 concentration not reported* IJT 30(S1):5S-16SMagnesium Coco-Sulfate 1 not in current use* IJT 29(S2): 115-132,
2010Magnesium Glycinate 1 not in current use* IJT 32(S4):41-64,
2013Magnesium Hydroxide 1 safe in hair straighteners and
depilatories under conditionsFinal report 12/2015
available from CIR
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
of recommended use: usersshould minimize skin contact;
all other uses safe whenformulated to be non-irritating
Magnesium Isododecylbenzenesulfonate (amended) 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 29 (S4) 288-305,2010
Magnesium laureth-3 sulfosuccinate 1 safe in the present practices ofuse and concentration when
formulated to be non-irritating
Final report 03/12available from CIR
Magnesium Laureth Sulfate 1 safe in the present practices ofuse and concentration when
formulated to be non-irritating
IJT29(S3) :151-161,2010
Magnesium Methyl Cocoyl Taurate* 1 when formulatedto be non-irritating
Final Report 12/2015available from CIR
Magnesium Myristate 1 up to 10% IJT 29(S3):162-186,2010
Magnesium Oleth Sulfate 1 safe in the present practices ofuse and concentration when
formulated to be non-irritating
IJT29(S3) :151-161,2010
Magnesium palmitoyl glutamate 1 not in current use* safe for use in cosmeticswhen formulated
to be non- irritating
Final report 12/2013available from CIR
Magnesium PCA 1 safe as used; shouldnot be used in cosmetic
products in which N-nitrosocompounds can be formed
Final report 12/2014available from CIR
Magnesium Salicylate 1 safe when formulated toavoid irritation and to avoidincreasing sun sensitivity,
or when increased sunsensitivity would be expected,directions for use include thedaily use of sun protection.
IJT 22(3):1-108
Magnesium Silicate 1 not in current use* IJT 22(S1):37-102,2003
Magnesium Stearate 1 up to 8% JACT 1(2):143-177, 1982
confirmed 11/01 IJT22(S1):1-35, 2003
Magnesium Sulfate 1 Final report 06/2014available from CIR
Magnesium Thioglycolate 1 in hair straighteners,permanent waves, tonics,dressings, etc., wave sets,other non-coloring hairproducts, and hair dyes
and colors; safe at 15.2%(as thioglycolic acid);
IJT 28(S3):68-133,2009
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
hairdressers should avoidskin contact and minimizeconsumer skin exposure
Magnesium Trisilicate 1 not in current use* IJT 22(S1):37-102,2003
Magnisium Myreth Sulfate 1 safe in the present practices ofuse and concentration when
formulated to be non-irritating
IJT29(S3) :151-161,2010
Maleic Acid 1 up to 0.004% as a pH adjuster safe for use as a pH adjuster;fragrance use not addressed
IJT 26(S2):125-130,2007
Malic Acid 1 safe for use as pH adjusters;insufficient data to support
safety for other uses
IJT 20(S1):47-55,2001
Malonic Acid 1 not in current use* IJT 31 (S1):5-76,2012
Maltitol 1 up to 15% Final report 09/08available from CIR
Maltitol Laurate 1 not in current use* Final report 09/08available from CIR
Maltodextrin 1 Final report 09/2015available from CIR
Maltose 1 Final report 03/2014available from CIR
Malus Domestica (Apple) Callus Extract* 1 Final report 03/2016available from CIR
Malus Domestica (Apple) Fiber 1 when formulated to be non-irritating and non-sensitizing
Final report 03/2016available from CIR
Malus Domestica (Apple) Fruit Cell Culture Extract 1 when formulated to be non-irritating and non-sensitizing
Final report 03/2016available from CIR
Malus Domestica (Apple) Fruit Extract 1 when formulated to be non-irritating and non-sensitizing
Final report 03/2016available from CIR
Malus Domestica (Apple) Fruit Water 1 when formulated to be non-irritating and non-sensitizing
Final report 03/2016available from CIR
Malus Domestica (Apple) Juice 1 when formulated to be non-irritating and non-sensitizing
Final report 03/2016available from CIR
Malus Domestica (Apple) Oil 1 Final report 03/2016available from CIR
Malus Domestica (Apple) Stem Extract 1 Final report 03/2016available from CIR
m-Aminophenol 1 up to 5% JACT 7(3):279-333,1988 confirmed
09/05Manganese citrate 1 not in current use* IJT 33 (S2): 16-46,
2014Manganese tripeptide-1 1 not in current use* Final report 06/2014
available from CIR
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Mangifera Indica (Mango) Seed Butter 1 0.0005 to 3% Final report 03/11available from CIR
Mangifera Indica (Mango) Seed Oil 1 0.003 to 6% Final report 03/11available from CIR
Mango Seed Oil PEG-70 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Mannan 1 Final report 09/2015available from CIR
Mannose 1 Final report 03/2014available from CIR
m-Cresol and o-Cresol 1 up to 0.5% IJT 25 (S1):29-127,2006 (Amended
Report)MEA-benzoate 1 safe in the present practices
of use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
Final amended report03/12 available from
CIR
MEA-cocoate 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
Final amended report03/12 available from
CIR
Meadowfoamamidopropyl Betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
IJT 31(S1):77-111,2012
MEA-laureth-6 carboxylate 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
Final amended report03/12 available from
CIR
MEA-laureth sulfate 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmetic
Final amended report03/12 available from
CIR
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
products in which N-nitrosocompounds may be formed
MEA-lauryl sulfate 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
Final amended report03/12 available from
CIR
MEA-PPG-8 steareth-7 carboxylate 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
Final amended report03/12 available from
CIR
MEA-PPG laureth-6 carboxylate 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
Final amended report03/12 available from
CIR
MEA-Salicylate (amended) 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed;
when used as a salicylateingredient, safe when
Final amended report03/12 available fromCIR; IJT 22(3):1-108
(original salicylatereport)
MEA-sulfite 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
Final amended report03/12 available from
CIR
MEA-tallowate 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
Final amended report03/12 available from
CIR
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
MEA-undecylenate 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
Final amended report03/12 available from
CIR
Melamine/Formaldehyde Resin (now calledPolyoxymethylene Melamine)
0 JACT 14(5):373-85,1995
Melibiose 1 Final report 03/2014available from CIR
Mentha Piperita (Peppermint) Leaf 1 safe as used, except that theconcentration of pulegone
should not exceed 1%
IJT 20(S3):61-73,2001
Mentha Piperita (Peppermint) Leaf Extract 1 safe as used, except that theconcentration of pulegone
should not exceed 1%
IJT 20(S3):61-73,2001
Mentha Piperita (Peppermint) Leaf Water 1 safe as used, except that theconcentration of pulegone
should not exceed 1%
IJT 20(S3):61-73,2001
Mentha Piperita (Peppermint) Oil 1 safe as used, except that theconcentration of pulegone
should not exceed 1%
IJT 20(S3):61-73,2001
Methacrylic Acid 1 safe as a nail primer in thepresent practices of use bytrained professionals, but
insufficient data to supportretail use by consumers
IJT 24(S5):33-51,2005
Methacrylic Acid/PEG-6 Methacrylate/PEG-6Dimethacrylate Crosspolymer
1 safe in the present practices ofuse and concentration whennot polymerized in benzene
Final report 11/2011available from CIR
Methacrylic Acid\ Styrene\ VP Copolymer 1 Final report 09/2014available from CIR
Methacryloyl Ethyl Betaine/Acrylates Copolymer 1 safe for use whenformulated to avoid irritation
IJT 21(S3):1-50,2002
Methenamine 1 0.16%; but should notbe used in products
intended to be aerosolized
JACT 11(4):531-58,1992
Methicone 1 up to 5% IJT 22(S2):11-35,2003
Methionine 1 0.0001 to 0.07% IJT 32(S4):41-64,2013
Methoxydiglycol Methacrylate 1 safe in nail enhancementproducts when skin contact is
IJT 24(S5):53-100,2005
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
avoided; products containingthis ingredient should be
accompanied with directionsto avoid skin contact
because of the sensitizingpotential of methacrylates
Methoxyisopropanol 1 up to 35%in nail careproducts; fragranceuse not addressed
IJT 27(S2): 25-29,2008
Methoxyisopropyl Acetate 1 not in current use* IJT 27(S2): 25-29,2008
Methoxy PEG/PPG-25/4 Dimethicone 1 Final report 12/2014available from CIR
Methoxy PEG-10 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Methoxy PEG-100 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
Methoxy PEG-11 Methoxy PPG-24 Dimethicone* 1 Final report 12/2014available from CIR
Methoxy PEG-13 Ethyl Polysilsesquioxane* 1 Final report 12/2014available from CIR
Methoxy PEG-16 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Methoxy PEG-25 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Methoxy PEG-40 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Methoxy PEG-7 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Methyl Acetate 1 10 to 60% IJT 31(S1):112-136,2012
Methyl Alcohol 1 safe for use as a denaturant IJT 20(S1):57-85,2001
Methylbenzethonium Chloride 1 0.5% skin; 0.02% eye JACT 4(5):65-106,1985 confirmed
03/04 IJT 25(S2),2006
Methyl Benzoate 1 0.0005 to 0.3% IJT 31(3):342 -372(2012)
Methylcellulose (amended) 1 up to 20% Amended safetyassessment 03/09 -
Available from CIR
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
JACT 5(3)1-59, 1986(original report)
Methylchloroisothiazolinone (with Methylisothiazolinone) 1 rinse-off 15 ppm;leave-on 7.5 ppm
JACT 11(1):75-128,1992
Methyl Cocoate (amended) 1 up to 0.06% IJT 30 (S1):5S-16SMethyl Cyclodextrin 1 Final report 09/2015
available from CIRMethyldibromo Glutaronitrile 1 leave-on 0.025% JACT 15(2):140-65,
1996Methylene Chloride 1 brief, discontinuous use only 7 JACT 7(6):741-835,
19887Methylene Glycol 1 1 safe for use in cosmetics
when formulated toensure use at the minimaleffective concentration,but in no case should theformalin concentration
exceed 0.2% (w/w), whichwould be 0.074% (w/w)
calculated as formaldehyde or0.118% (w/w) calculated as
IJT 32(S4):5-32,2013
Methyl Ethylcellulose 1 not in use at the time* Amended SafetyAsessment 03/09
available from CIRMethyl Gluceth-10 1 Final report 09/2013
available from CIRMethyl Gluceth-20 1 Final report 09/2013
available from CIRMethyl glucose caprylate/caprate 1 Final report 09/2013
available from CIRMethyl glucose dioleate 1 Final report 09/2013
available from CIRMethyl glucose isostearate 1 Final report 09/2013
available from CIRMethyl glucose laurate 1 Final report 09/2013
available from CIRMethyl glucose sesquicaprylate/sesquicaprate 1 Final report 09/2013
available from CIRMethyl glucose sesquicocoate 1 Final report 09/2013
available from CIRMethyl glucose sesquiisostearate 1 Final report 09/2013
available from CIRMethyl glucose sesquilaurate 1 Final report 09/2013
available from CIRMethyl glucose sesquioleate 1 Final report 09/2013
available from CIRMethyl glucose sesquistearate 1 Final report 09/2013
available from CIR
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Methyl Glycolate 1 safe for use in cosmeticproducts at concentrationsless than or equal to10%,at final formulation pH
greater than or equal to3.5,when formulated to avoidincreasing sun sensitivityor when directions for use
include the daily use of sunprotection. These ingredients
are safe for use in sal
IJT 17(S1):1-242,1998
Methyl Glycyrrhizate 1 not in current use* IJT 26(S2):79-112,2007
Methyl Hydroxyethylcellulose 1 not in use at the time* Amended SafetyAssesment 03/09
available from CIRMethyl Isobutyl Ketone (aka MIBK) 1 safe as used in nail polish
removers and up to 4%as an alcohol denaturant
IJT 23(S1):29-57,2003
Methylisothiazolinone (alone) 1 safe at concentrations upto 100 ppm and safe foruse in leave-on cosmetic
products when formulatedto be non-sensitizingm
which may be determinedbased on a quantitativerisk assessment (QRA).
IJT 29 (S3): 187-213,2010; Final report09/2014 available
from CIR
Methylisothiazolinone (with Methylchloroisothiazolinone) 1 rinse-off 15 ppm;leave-on 7.5 ppm
JACT 11(1):75-128,1992
Methyl Lactate 1 safe for use in cosmeticproducts at concentrationsless than or equal to10%,at final formulation pH
greater than or equal to3.5,when formulated to avoidincreasing sun sensitivityor when directions for use
include the daily use of sunprotection. These ingredients
are safe for use in sal
IJT 17(S1):1-242,1998
Methyl Methacrylate/Glycol Dimethacrylate Crosspolymer 1 up to 3% IJT 30 (1): 54-65,2011
Methyl Methacrylate Crosspolymer 1 up to 14% IJT 30 (1): 54-65,2011
Methyl Myristate 1 not in use at the time* IJT29(S3) :162-186,2010
Methylparaben (amended) 1 up to 0.4% if used alone;parabens mixture up to 0.8%
IJT 27(S4): 1-82,2008 JACT
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Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
3(5):147-209, 1984(original report)
Methyl Pelargonate 1 not in current use* Final report 06/10available from CIR
Methyl Ricinoleate 1 not in current use* IJT 26(S3) 2007Methyl Salicylate 1 safe when formulated to
avoid irritation and to avoidincreasing sun sensitivity,
or when increased sunsensitivity would be expected,directions for use include thedaily use of sun protection.
IJT 22(3):1-108
Methylstyrene/Vinyltoluene Copolymer 1 Final report 09/2014available from CIR
Methyl Thioglycolate 1 in hair straighteners,permanent waves, tonics,dressings, etc., wave sets,other non-coloring hairproducts, and hair dyes
and colors; safe at 15.2%(as thioglycolic acid);
hairdressers should avoidskin contact and minimizeconsumer skin exposure
IJT 28(S3):68-133,2009
MIBK (aka Methyl Isobutyl Ketone) 1 safe as used in nail polishremovers and up to 4%as an alcohol denaturant
IJT 23(S1):29-57,2004
Microbial Polysaccharide Gums (see CIR Report with samename)
Final report 09/12available from CIR
Microcitrus Australasica Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Microcitrus Australis Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Microcrystalline Cellulose (amended) 1 up to 57% Amended safetyassessment 03/09 -
Available from CIR
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Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Microcrystalline Wax 1 up to 50% JACT 3(3):43- 99,1984 confirmed
06/03 IJT24(S1):67-74, 2005
Milkamidopropyl betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
IJT 31(S1):77-111,2012
Milk amino acids 1 IJT 33(S4):5-12,2014
Minkamide DEA 1 safe in the present practices ofuse and concentration when
formulated to be non-irritatingand when the levels of freeDEA do not exceed those
considered safe int the CIRsafety assessment of DEAand its salts; should not beused in cosmetic products
IJT 32(S1):36-58,2013
Minkamidopropyl betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
IJT 31(S1):77-111,2012
Minkamidopropyl dimethylamine 1 safe in cosmetics as longas they are formulatedto be non-sensitizing,
which may be based on aquantitative risk assessment
Final report 06/2014available from CIR
Mink Oil (Amended) 1 up to 3% IJT 24(S3):57-64,2005 IJT
17(S4):71-82, 1998(Original Report)
mink oil PEG-13 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
MIPA-Dodecylbenzenesulfonate (amended) 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 29 (S4) 288-305,2010
Mixed Cresols (amended) 1 IJT 25(S1):29-127,2006
Mixed Isopropanolamines 1 safe for use in cosmeticproducts; but should not beused in products containing
N-nitrosating agents
JACT 6(1):53-76,1987 confirmed
12/04 IJT 25(S2),2006
Monoethanolamine (now Ethanolamine) 1 safe for use in rinse-offproducts; but should not beused in leave-on products
JACT 2(7):183-235,1983
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Monosodium citrate 1 0.004 to 5% IJT 33 (S2): 16-46,2014
Montan Wax 1 up to 11% JACT 3(3):43-99,1984 confirmed
06/03 IJT24(S1):67-74, 2005
Montmorillonite 1 not in current use* IJT 22 (S1):37-102,2003
Morinda Citrifolia Seed Oil 1 not in current use* Final report 03/11available from CIR
Moringa Oleifera Seed Oil 1 up to 0.001% Final report 03/11available from CIR
Moringa Pterygosperma Seed Oil 1 0.003 to 3% Final report 12/10available from CIR
Morpholine 1 JACT 8(4):707-748,1989
m-Phenylenediamine 1 10% in hair dyes IJT 16(S1):59-116,1997
m-Phenylenediamine Sulfate 1 10% in hair dyes IJT16(S1):59-116,1997
Myreth-10 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Myreth-2 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Myreth-3 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Myreth-4 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Myreth-5 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Myristamide DEA 1 safe in the present practices ofuse and concentration when
formulated to be non-irritatingand when the levels of freeDEA do not exceed those
considered safe int the CIRsafety assessment of DEAand its salts; should not beused in cosmetic products
IJT 32(S1):36-58,2013
Myristamide MEA (amended) 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to be
IJT 34(S1): 18-34,2015
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
non-irritating; shouldnot be used in cosmetic
products in which N-nitrosocompounds may be formed
Myristamidopropyl betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
IJT 31(S1):77-111,2012
Myristamidopropyl dimethylamine 1 not in current use* safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
Final report 06/2014available from CIR
Myristic Acid 1 up to 50% JACT 6(3):321-401,1987 confirmed
06/05 IJT 25(S2),2006; IJT 29 (S3):
162-186, 2010Myristoyl ethyltrimonium methosulfate 1 Safe in the present practices of
use and concentration, whenformulated to be non-irritating
IJT 31(S3): 296-341(2012)
Myristoyl glutamic acid 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Myristoyl hexapeptide-12 1 not in current use* Final report 06/2014available from CIR
Myristoyl pullulan 1 not in current use* Final report 09/12available from CIR
Myristoyl Sarcosine 1 safe as used in rinse-offproducts; but 5% in leave-on products. Should not beused in products where N-nitroso compounds may beformed. Insufficient data todetermine safety in products
where these ingredientsare likely to be inhaled.
IJT 20(S1):1-14,2001
Myristoyl tripeptide-1 1 not in current use* Final report 06/2014available from CIR
Myristyl Acetate 1 not in use at the time* IJT 31(S1):112-136,2012
Myristyl Alcohol 1 up to 5% JACT 7(3):359-413,1988 confirmed
12/05Myristyl Betaine 1 up to 0.84% safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2014
available from CIRMyristyl Ethylhexanoate 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIR
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Myristyl Glucoside 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 32 (S3): 22-48,2013
Myristyl Glycol 1 not in use at the time* IJT 31 (S2): 147-168,2012
Myristyl Isostearate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Myristyl Lactate (Amended) 1 safe for use in cosmeticproducts at concentrationsless than or equal to10%,at final formulation pH
greater than or equal to3.5,when formulated to avoidincreasing sun sensitivityor when directions for use
include the daily use of sunprotection. These ingredients
are safe for use in sal
IJT 17(S1):1-242,1998 JACT
1(2):97-107, 1982(Original Report)
Myristyl Laurate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Myristyl Myristate 1 up to 17% safe for use in cosmetics whenformulated to be non-irritating
JACT 1(4):55-80,1982 confirmed
06/02 IJT24(S1):63-67, 2005;final report 03/2013available from CIR
Myristyl Neopentanoate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Myristyl Phosphate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2014available from CIR
Myristyl Salicylate 1 safe when formulated toavoid irritation and to avoidincreasing sun sensitivity,
or when increased sunsensitivity would be expected,directions for use include thedaily use of sun protection.
IJT 22(3):1-108
Myristyl Stearate 1 up to 4% safe for use in cosmetics whenformulated to be non-irritating
JACT 4(5):107-46,1985 confirmed
06/03 IJT24(S1):21-25, 2005;final report 03/2013available from CIR
Myrtrimonium bromide 1 safe when formulatedto be non- irritating
IJT 31(S3): 296-341(2012)
N,N-Bis(2-Hydroxyethyl)-p- Phenylenediamine Sulfate 1 up to 5% JACT 11(1):129-43,1992
n-Butane (aka Butane) 1 up to 92% JACT 1 (4):127-42,1982 confirmed
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
06/02 IJT24(S1):52-55, 2005
n-Butyl Alcohol 1 up to 15% in nail products, upto 0.002% in other products
IJT 27(S2): 53-69,2008 JACT
6(3):403-25, 1987(Original Report)
Neopentyl Glycol Dicaprylate/Dipelargonate/Dicaprate 1 not in use at the time* Final report 06/10available from CIR
Neopentyl glycol diisononanoate 1 1% IJT 30 (S3):228-269,2011
Niacin 1 Niacin less than or equalto 0.1%; Niacinamide
less than or equal to3%
IJT 24(S5):1-31,2005
Niacinamide 1 Niacin less than or equalto 0.1%; Niacinamide
less than or equal to3%
IJT 24(S5):1-31,2005
Nitrocellulose 1 Final report 06/13available from CIR
Noneth-8 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Nonoxynol-1 1 when formulatedto be non-irritating
IJT 18(S1):11-31,1999; Final report12/2015 available
from CIRNonoxynol-10 1 when formulated
to be non-irritatingJACT 2(7):35-60,1983; Final report12/2015 available
from CIRNonoxynol-100 1 when formulated
to be non-irritatingFinal report 12/2015
available from CIRNonoxynol-11 1 when formulated
to be non-irritatingFinal report 12/2015
available from CIRNonoxynol-12 1 when formulated
to be non-irritatingJACT 2(7):35-60,1983; Final report12/2015 available
from CIRNonoxynol-120 1 when formulated
to be non-irritatingFinal report 12/2015
available from CIRNonoxynol-13 1 when formulated
to be non-irritatingFinal report 12/2015
available from CIRNonoxynol-14 1 when formulated
to be non-irritatingJACT 2(7):35-60,1983; Final report12/2015 available
from CIRNonoxynol-15 1 when formulated
to be non-irritatingJACT 2(7):35-60,1983; Final report
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
12/2015 availablefrom CIR
Nonoxynol-18 1 when formulatedto be non-irritating
Final report 12/2015available from CIR
Nonoxynol-2 1 when formulatedto be non-irritating
IJT 18(S1):11-31,1999 JACT
2(7):35-60, 1983(Original Report);
Final report 12/2015available from CIR
Nonoxynol-20 1 when formulatedto be non-irritating
Final report 12/2015available from CIR
Nonoxynol-23 1 when formulatedto be non-irritating
Final report 12/2015available from CIR
Nonoxynol-25 1 when formulatedto be non-irritating
Final report 12/2015available from CIR
Nonoxynol-3 1 when formulatedto be non-irritating
IJT 18(S1):11-31,1999; Final report12/2015 available
from CIRNonoxynol-30 1 when formulated
to be non-irritatingJACT 2(7):35-60,1983; Final report12/2015 available
from CIRNonoxynol-35 1 when formulated
to be non-irritatingFinal report 12/2015
available from CIRNonoxynol-4 1 when formulated
to be non-irritatingIJT 18(S1):11-31,
1999 JACT2(7):35-60, 1983
(Original Report);Final report 12/2015
available from CIRNonoxynol-40 1 when formulated
to be non-irritatingJACT 2 (7):35-60,1983; Final report12/2015 available
from CIRNonoxynol-44 1 when formulated
to be non-irritatingFinal report 12/2015
available from CIRNonoxynol-5 1 when formulated
to be non-irritatingIJT 18(S1):11-31,1999; Final report12/2015 available
from CIRNonoxynol-50 1 when formulated
to be non-irritatingJACT 2(7):35-60,1983; Final report12/2015 available
from CIRNonoxynol-6 1 when formulated
to be non-irritatingIJT 18(S1):11-31,1999; Final report
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
12/2015 availablefrom CIR
Nonoxynol-7 1 when formulatedto be non-irritating
IJT 18(S1):11-31,1999; Final report12/2015 available
from CIRNonoxynol-70 1 when formulated
to be non-irritatingFinal report 12/2015
available from CIRNonoxynol-8 1 when formulated
to be non-irritatingIJT 18(S1):11-31,
1999 JACT2(7):35-60, 1983
(Original Report);Final report 12/2015
available from CIRNonoxynol-9 1 when formulated
to be non-irritatingJACT 2(7):35-60,1983; Final report12/2015 available
from CIRNonyl Acetate 1 0.0004% IJT 31(S1):112-136,
2012N-Phenyl-p-Phenylenediamine 1 up to 1.7% as the free base JACT 13(5):374-94,
1994N-Phenyl-p-Phenylenediamine HCl 1 up to 1.7% as the free base JACT 13(5):374-94,
1994N-Phenyl-p-Phenylenediamine Sulfate 1 up to 1.7% as the free base JACT 13(5):374-94,
1994Nylon-10/10 1 not in current use* IJT 33(S4):47-60,
2014Nylon-11 1 IJT 33(S4):47-60,
2014Nylon-12 1 IJT 33(S4):47-60,
2014Nylon-12/6/66 1 not in current use* IJT 33(S4):47-60,
2014Nylon-6 1 IJT 33(S4):47-60,
2014Nylon 6/12 1 IJT 33(S4):47-60,
2014Nylon-611 1 not in current use* IJT 33(S4):47-60,
2014Nylon-66 1 IJT 33(S4):47-60,
2014o-aminophenol 1 up to 1% JACT 7(3):279-333,
1988 confirmed09/05
Oatamide MEA 1 safe in the present practicesof use and concentration(rinse-off products only)
IJT 34(S1): 18-34,2015
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
Oatamidopropyl betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
IJT 31(S1):77-111,2012
Oatamidopropyl dimethylamine 1 not in current use* safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
Final report 06/2014
Oat amino acids 1 IJT 33(S4):5-12,2014
Octacosanyl Glycol 1 not in use at the time* IJT 31 (S2): 147-168,2012
Octacotrimonium chloride 1 Safe as used in cosmeticswhen formulated
to be non-irritating
IJT 31(S3): 296-341(2012)
Octadecyl D-glucoside 1 Safe as used in cosmeticswhen formulated
to be non-irritating
IJT 32 (S3): 22-48,2013
Octododecyl Avocadoate 1 not in current use* Safe as used in cosmeticswhen formulated
to be non-irritating
Final report 03/2013available from CIR
Octododecyl Beeswax 1 not in current use* Safe as used in cosmeticswhen formulated
to be non-irritating
Final report 03/2013available from CIR
Octododecyl Behenate 1 not in current use* Safe as used in cosmeticswhen formulated
to be non-irritating
Final report 03/2013available from CIR
Octododecyl Benzoate 1 3 to 4% IJT 31(3):342- 372(2012)
Octododecyltrimonium chloride 1 safe when formulatedto be non- irritating
IJT 31(S3): 296-341(2012)
Octoxynol-1 1 up to 30% in permanentwaves, lower for other uses
safe as used in rinse-off products; safe at 5%
in leave-on products
IJT 23(S1):59-111,2004
Octoxynol-10 1 up to 25% in hair bleaches IJT 23(S1):59-111,2004
Octoxynol-11 1 up to 1% IJT 23(S1):59-111,2004
Octoxynol-12 1 not in current use* IJT 23 (S1):59-111,2004
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Octoxynol-13 1 up to 2% IJT 23(S1):59-111,2004
Octoxynol-16 1 not in current use* IJT 23 (S1):59-111,2004
Octoxynol-20 1 not in current use* IJT 23 (S1):59-111,2004
Octoxynol-20 Carboxylic Acid 1 not in current use* IJT 23(S1):59-111,2004
Octoxynol-25 1 not in current use* IJT 23 (S1):59-111,2004
Octoxynol-3 1 not reported* safe as used in rinse-off products; safe at 5%
in leave-on products
IJT 23(S1):59-111,2004
Octoxynol-30 1 up to 2% IJT 23(S1):59-111,2004
Octoxynol-33 1 not in current use* IJT 23 (S1):59-111,2004
Octoxynol-40 1 up to 0.02% IJT 23(S1):59-111,2004
Octoxynol-5 1 not reported* safe as used in rinse-off products; safe at 5%
in leave-on products
IJT 23(S1):59-111,2004
Octoxynol-6, -7, and -8 1 not in current use* safe as used in rinse-off products; safe at 5%
in leave-on products
IJT 23(S1):59-111,2004
Octoxynol-7 1 not in current use* safe as used in rinse-off products; safe at 5%
in leave-on products
IJT 23(S1):59-111,2004
Octoxynol-70 1 not in current use* IJT 23 (S1):59-111,2004
Octoxynol-8 1 not in current use* safe as used in rinse-off products; safe at 5%
in leave-on products
IJT 23(S1):59-111,2004
Octoxynol-9 1 up to 5% IJT 23(S1):59-111,2004
Octoxynol-9 Carboxylic Acid 1 not in current use* IJT 23(S1):59-111,2004
Octyldecyl Oleate 1 not in current use* Safe as used in cosmeticswhen formulated
to be non-irritating
Final report 03/2013available from CIR
Octyldecyl Phosphate 1 not in current use* Safe as used in cosmeticswhen formulated
to be non-irritating
Final report 09/2014available from CIR
Octyldodecanol 1 up to 85% JACT 4(5):1-29,1985 confirmed
03/04; IJT 25(S2),2006
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Octyldodeceth-10 1 Safe as used in cosmeticswhen formulated
to be non-irritating
IJT 31(S2):169-244(2012)
Octyldodeceth-16 1 Safe as used in cosmeticswhen formulated
to be non-irritating
IJT 31(S2):169-244(2012)
Octyldodeceth-2 1 Safe as used in cosmeticswhen formulated
to be non-irritating
IJT 31(S2):169-244(2012)
Octyldodeceth-20 1 Safe as used in cosmeticswhen formulated
to be non-irritating
IJT 31(S2):169-244(2012)
Octyldodeceth-25 1 Safe as used in cosmeticswhen formulated
to be non-irritating
IJT 31(S2):169-244(2012)
Octyldodeceth-30 1 Safe as used in cosmeticswhen formulated
to be non-irritating
IJT 31(S2):169-244(2012)
Octyldodeceth-5 1 Safe as used in cosmeticswhen formulated
to be non-irritating
IJT 31(S2):169-244(2012)
Octyldodecyl Cocoate (amended) 1 not in current use* Safe as used in cosmeticswhen formulated
to be non-irritating
IJT 30(S1):5S-16S;final report 03/2013available from CIR
Octyldodecyl Erucate 1 not in current use* Safe as used in cosmeticswhen formulated
to be non-irritating
Final report 03/2013available from CIR
Octyldodecyl Ethylhexanoate 1 not in current use* Safe as used in cosmeticswhen formulated
to be non-irritating
Final report 03/2013available from CIR
Octyldodecyl Glucoside 1 Safe as used in cosmeticswhen formulated
to be non-irritating
IJT 32 (S3): 22-48,2013
Octyldodecyl Hydroxystearate 1 Safe as used in cosmeticswhen formulated
to be non-irritating
Final report 03/2013available from CIR
Octyldodecyl Isostearate 1 Safe as used in cosmeticswhen formulated
to be non-irritating
Final report 03/2013available from CIR
Octyldodecyl Meadowfoamate 1 not in current use* Safe as used in cosmeticswhen formulated
to be non-irritating
Final report 03/2013available from CIR
Octyldodecyl Myristate 1 up to 21% Safe as used in cosmeticswhen formulated
to be non-irritating
IJT29(S3) :162-186,2010;
final report 03/2013available from CIR
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Octyldodecyl Neodecanoate 1 not in current use* Safe as used in cosmeticswhen formulated
to be non-irritating
Final report 03/2013available from CIR
Octyldodecyl Neopentanoate 1 Safe as used in cosmeticswhen formulated
to be non-irritating
Final report 03/2013available from CIR
Octyldodecyl Octyldodecanoate 1 Safe as used in cosmeticswhen formulated
to be non-irritating
Final report 03/2013available from CIR
Octyldodecyl Oleate 1 not in current use* Safe as used in cosmeticswhen formulated
to be non-irritating
Final report 03/2013available from CIR
Octyldodecyl Olivate 1 Safe as used in cosmeticswhen formulated
to be non-irritating
Final report 03/2013available from CIR
Octyldodecyl Ricinoleate 1 up to 5% Safe as used in cosmeticswhen formulated
to be non-irritating
IJT 26(S3) 2007;final report 03/2013available from CIR
Octyldodecyl Safflowerate 1 not in current use* Safe as used in cosmeticswhen formulated
to be non-irritating
Final report 03/2013available from CIR
Octyldodecyl Stearate 1 Safe as used in cosmeticswhen formulated
to be non-irritating
Final report 03/2013available from CIR
Octyldodecyl Stearoyl Stearate (amended) 1 up to 15% IJT 24(S3):65-74,2005 IJT
20(S3):51-59, 2001(Original report)
o-Cymen-5-ol (Amended) 1 up to 0.5% IJT 25 (S1):29-127,2006 JACT
3(3):131-55, 1984(Original Report)
Oenothera Biennis (Evening Primrose) Oil 1 0.00002 to 58% Final report 03/11available from CIR
Olea Europaea (Olive) Fruit Oil 1 0.0005 to 100% Final report 03/11available from CIR
Olea Europaea (Olive) Husk Oil 1 not in current use* Final report 03/11available from CIR
Olea Europaea (Olive) Oil Unsaponifiables 1 0.0001 to 3% Final report 03/11available from CIR
Oleamide DEA (amended) 1 safe in the present practices ofuse and concentration when
formulated to be non-irritatingand when the levels of freeDEA do not exceed those
considered safe int the CIRsafety assessment of DEA
JACT 5(5):415-454,1986 (originalreport); IJT 32
(S1):36-58, 2013
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
and its salts; should not beused in cosmetic products
Oleamide MEA 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
IJT 34(S1): 18-34,2015
Oleamidopropyl betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
IJT 31(S1):77-111,2012
Oleamidopropyl dimethylamine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
Final report 06/2014available from CIR
Oleic Acid 1 up to 50% JACT 6(3):321-401,1987 confirmed
06/05 IJT 25(S2),2006
Oleoyl Sarcosine 1 safe as used in rinse-offproducts; but 5% in leave-on products. Should not beused in products where N-nitroso compounds may beformed. Insufficient data todetermine safety in products
where these ingredientsare likely to be inhaled.
IJT 20(S1):1-14,2001
Oleoyl Tyrosine 1 Safe as used in cosmeticswhen formulated
to be non-irritating
Final report 12/2013available from CIR
Oleth-10 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Oleth-100 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Oleth-106 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Oleth-11 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Oleth-12 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Oleth-15 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Oleth-16 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Oleth-2 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Oleth-20 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Oleth-23 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Oleth-24 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Oleth-25 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Oleth-3 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Oleth-30 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Oleth-35 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Oleth-4 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Oleth-40 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Oleth-44 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Oleth-45 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Oleth-5 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Oleth-50 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Oleth-6 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Oleth-7 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Oleth-8 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Oleth-82 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Oleth-9 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Oleyl Alcohol 1 up to 62% JACT 4(5):1-29,1985 confirmed
03/04 IJT 25(S2),2006
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Oleyl Arachidate 1 not in current use* safe as used in cosmeticswhen formulated
to be non-irritating
Final report 03/2013available from CIR
Oleyl Betaine 1 up to 23.7% safe as used in cosmeticswhen formulated
to be non-irritating
Final report 03/2014available from CIR
Oleyl Erucate 1 safe as used in cosmeticswhen formulated
to be non- irritating
Final report 03/2013available from CIR
Oleyl Ethyl Phosphate 1 not in current use* Safe as used in cosmeticswhen formulated
to be non-irritating
Final report 09/2014available from CIR
Oleyl Glyceryl Ether 1 not in current use* IJT 32 (S3): 5-21,2013
Oleyl Linoleate 1 safe as used in cosmeticswhen formulated
to be non-irritating
Final report 03/2013available from CIR
Oleyl Myristate 1 not in current use* safe as used in cosmeticswhen formulated
to be non-irritating
IJT29(S3) :162-186,2010;
final report 03/2013available from CIR
Oleyl Oleate 1 safe as used in cosmeticswhen formulated
to be non- irritating
Final report 03/2013available from CIR
Oleyl Phosphate 1 not in current use* Safe as used in cosmeticswhen formulated
to be non-irritating
Final report 09/2014available from CIR
Oleyl Stearate 1 not in current use* safe as used in cosmeticswhen formulated
to be non-irritating
Final report 03/2013available from CIR
Olivamide DEA 1 safe in the present practices ofuse and concentration when
formulated to be non-irritatingand when the levels of freeDEA do not exceed those
considered safe int the CIRsafety assessment of DEAand its salts; should not beused in cosmetic products
IJT 32(S1):36-58,2013
Olivamide MEA 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
IJT 34(S1): 18-34,2015
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Olivamidopropyl betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
IJT 31(S1):77-111,2012
Olivamidopropyl dimethylamine 1 not in current use* safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
Final report 06/2014available from CIR
Olive Acid 1 not in use at the time* Final report 03/11available from CIR
Olive Oil PEG-10 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Olive oil PEG-6 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Olive Oil PEG-7 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Olive Oil PEG-8 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Olive Oil Propylene Glycol Esters* 1 safe when formulatedto be non- irritating
Final report 12/2014available from CIR
Orbignya Cohune Seed Oil 1 concentration not reported* Final report 03/11available from CIR
Orbignya Oleifera Seed Oil 1 0.0009 to 27% Final report 03/11available from CIR
orbignya oleifera seed oil PEG-8 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Orbignya Speciosa Kernel Oil 1 0.5 to 0.9% Final report 03/11available from CIR
Oryza Sativa (Rice) Bran 1 concentraton not reported* IJT 25(S2):91-120,2006
Oryza Sativa (Rice) Bran Acid 1 not in current use* These rice derivedingredients as used in
products should not containsignificant levels of pesticide
residues or heavy metals
IJT 25(S2):91-120,2006
Oryza Sativa (Rice) Bran Extract 1 concentraton not reported* IJT 25(S2):91-120,2006
Oryza Sativa (Rice) Bran Oil 1 0.0003 to 78% These rice derivedingredients as used in
products should not containsignificant levels of pesticide
residues or heavy metals
Final amended report03/11 availablefrom CIR; IJT
25(S2):91-120, 2006(original)
Oryza Sativa (Rice) Bran Wax 1 concentraton not reported* IJT 25(S2):91-120,2006
Oryza Sativa (Rice) Extract 1 not in current use* These rice derivedingredients as used in
IJT 25(S2):91-120,2006
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
products should not containsignificant levels of pesticide
residues or heavy metalsOryza Sativa (Rice) Germ Oil 1 0.003 to 3% These rice derived
ingredients as used inproducts should not contain
significant levels of pesticideresidues or heavy metals
Final amended report03/11 availablefrom CIR; IJT
25(S2):91-120, 2006(original)
Oryza Sativa (Rice) Germ Powder 1 concentraton not reported* IJT 25(S2):91-120,2006
Oryza Sativa (Rice) Seed Oil 1 not in use at the time* Final report 03/11available from CIR
Oryza Sativa (Rice) Starch 1 1 to 97% These rice derivedingredients as used in
products should not containsignificant levels of pesticide
residues or heavy metals
IJT 25(S2):91-120,2006
Oxidized beta-glucan 1 not in current use* Final report 09/12available from CIR
Oxyquinoline and Oxyquinoline Sulfate (Amended) 1 Safe for use as stabilizers forhydrogen peroxide in rinse-off hair products; insufficient
data for leave-on uses
IJT 25(S1):1-9, 2006JACT 11(4):497-507,1992 (original report)
Ozokerite 1 up to 22% JACT 3(3):43-99,1984 confirmed
06/03Palm (Elaeis Guineensis) Oil 1 up to 2% IJT 19 (S2):7-28,
2000Palm Acid 1 1 to 17% Final report 03/11
available from CIRPalmamide DEA 1 safe in the present practices of
use and concentration whenformulated to be non-irritating
and when the levels of freeDEA do not exceed those
considered safe int the CIRsafety assessment of DEAand its salts; should not beused in cosmetic products
IJT 32(S1):36-58,2013
Palmamide MEA 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
IJT 34(S1): 18-34,2015
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Palmamidopropyl betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
IJT 31(S1):77-111,2012
Palmeth-2 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Palmitamide DEA 1 safe in the present practices ofuse and concentration when
formulated to be non-irritatingand when the levels of freeDEA do not exceed those
considered safe int the CIRsafety assessment of DEAand its salts; should not beused in cosmetic products
IJT 32(S1):36-58,2013
Palmitamide MEA 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
IJT 34(S1): 18-34,2015
Palmitamidopropyl betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
IJT 31(S1):77-111,2012
Palmitamidopropyl dimethylamine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
Final report 06/2014available from CIR
Palmitic Acid 1 up to 25% JACT 6(3):321-401,1987 confirmed
06/05Palmitoyl alanine 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 12/2013
available from CIRPalmitoyl arginine 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 12/2013
available from CIRPalmitoyl carnitine 1 safe when formulated
to be non- irritatingIJT 31(S3): 296-341
(2012)Palmitoyl collagen amino acids 1 safe for use in cosmetics
when formulatedto be non- irritating
Final report 12/2013available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Palmitoyl glutamic acid 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Palmitoyl glycine 1 safe for use in cosmeticswhen formulated
to be non- irritating
Final report 12/2013available from CIR
Palmitoyl gold of pleasure amino acids 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Palmitoyl hexapeptide-12 1 Final report 06/2014available from CIR
Palmitoyl Inulin 1 Final report 09/2015available from CIR
Palmitoyl isoleucine 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
palmitoyl keratin amino acids 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
palmitoyl millet amino acids 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
palmitoyl oat amino acids 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
palmitoyl pea amino acids 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
palmitoyl proline 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
palmitoyl quinoa amino acids 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
palmitoyl silk amino acids 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Palmitoyl tetrapeptide-7 1 not in current use* Final report 06/2014available from CIR
Palm Kernel Acid 1 2 to 12% Final report 03/11available from CIR
Palm kernelamide DEA 1 safe in the present practices ofuse and concentration when
formulated to be non-irritatingand when the levels of freeDEA do not exceed those
considered safe int the CIRsafety assessment of DEAand its salts; should not beused in cosmetic products
Final amended report09/11 available from
CIR
Palm kernelamide MEA 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
IJT 34(S1): 18-34,2015
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Palm kernelamidopropyl betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
IJT 31(S1):77-111,2012
Palm Oil PEG-8 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
p-aminophenol 1 up to 1% JACT 7(3):279-333,1988 confirmed
09/05Pamitoyl ethyltrimonium methosulfate 1 safe when formulated
to be non-irritatingIJT 31(S3): 296-341
(2012)Pamitoyl tripeptide-1 1 Final report 06/2014
available from CIRPanax ginseng root 1 concentration not reported* Final report 09/12
available from CIRPanax ginseng root extract*** 1 0.000002 to 0.5% Final report 09/12
available from CIRPanax ginseng root oil 1 not in current use* Final report 09/12
available from CIRPanax ginseng root powder 1 concentration not reported* Final report 09/12
available from CIRPanax ginseng root protoplast 1 not in current use* Final report 09/12
available from CIRPanax ginseng root water 1 not in current use* Final report 09/12
available from CIRPanax japonicus root extract 1 not in current use* Final report 09/12
available from CIRPanax notoginseng root 1 0.0004% Final report 09/12
available from CIRPanax notoginseng root powder 1 not in current use* Final report 09/12
available from CIRPanax quinquefolium root extract 1 0.0005 to 0.002% Final report 09/12
available from CIRPanthenol 1 up to 25% JACT 6(1):139-62,
1987 confirmed12/04 IJT 25(S2),
2006Pantothenamide MEA 1 safe in the present practices
of use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
IJT 34(S1): 18-34,2015
Pantothenic Acid 1 not in use at the time* JACT 6(1):139-62,1987 confirmed
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
12/04 IJT 25(S2),2006
Paraffin 1 0.03 to 99% JACT 3(3):43-99,1984 confirmed
06/03 IJT24(S1):67-74, 2005
Passiflora Edulis Seed Oil 1 0.0007 to 3% IJT 31(S2):169-244(2012)
Passiflora edulis seed oils PEG-8 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
PCA 1 safe as used; shouldnot be used in cosmetic
products in which N-nitrosocompounds can be formed
IJT 18(S2):25-34,1999; Final report12/2014 available
from CIRp-Chloro-m-Cresol (amended) 1 up to 5% IJT 25 (S1):29-127,
2006 IJT16(S3):235-68,1997
(Original Report)p-Cresol (amended) 1 IJT 25(S1):29-127,
2006Peanut (Arachis Hypogaea) Flour 1 IJT 20(S2):65-77,
2001Peanut (Arachis Hypogaea) Oil 1 up to 25% IJT 20(S2):65-77,
2001Peanut Acid and Peanut Glycerides 1 not in current use* Final amended report
03/11 availablefrom CIR; IJT
20(S2):65-77, 2001(original)
Peanutamide MEA 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
IJT 34(S1): 18-34,2015
Peanut Oil PEG-6 Esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Pectin 1 Final report 09/2015available from CIR
PEG/PPG-10/2 Dimethicone* 1 Final report 12/2014available from CIR
PEG/PPG-10/2 Propylheptyl Ether 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2013available from CIR
PEG/PPG-10/3 Oleyl Ether Dimethicone* 1 Final report 12/2014available from CIR
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
PEG/PPG-12/16 Dimethicone* 1 Final report 12/2014available from CIR
PEG/PPG-12/18 Dimethicone* 1 Final report 12/2014available from CIR
PEG/PPG-14/2 Propylheptyl Ether 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2013available from CIR
PEG/PPG-14/4 Dimethicone 1 JACT 1(4):33-54,1982 confirmed
02/03 IJT24(S1):42-44, 2005;Final report 12/2014
available from CIRPEG/PPG-14/7 Dimethyl Ether 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 09/2013
available from CIRPEG/PPG-15/15 Dimethicone 1 IJT 24(Suppl.
1):1-102, 2005;Final report 12/2014
available from CIRPEG/PPG-15/5 Dimethicone* 1 Final report 12/2014
available from CIRPEG/PPG-16/2 Dimethicone* 1 IJT 24(Suppl.
1):1-102, 2005;Final report 12/2014
available from CIRPEG/PPG-16/8 Dimethicone* 1 Final report 12/2014
available from CIRPEG/PPG-17/18 Dimethicone 1 JACT 1(4):33-54,
1982 confirmed02/03 IJT
24(S1):42-44, 2005;Final report 12/2014
available from CIRPEG/PPG-17/4 Dimethyl Ether 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 09/2013
available from CIRPEG/PPG-18/12 Dimethicone* 1 Final report 12/2014
available from CIRPEG/PPG-18/18 Dimethicone 1 JACT 1(4):33-54,
1982 confirmed02/03 IJT
24(S1):42-44, 2005;Final report 12/2014
available from CIRPEG/PPG-18/6 Dimethicone* 1 Final report 12/2014
available from CIRPEG/PPG-19/19 Dimethicone 1 IJT 24(Suppl.
1):1-102, 2005;Final report 12/2014
available from CIR
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
PEG/PPG-20/15 Dimethicone 1 JACT 1(4):33-54,1982 confirmed
02/03 IJT24(S1):42-44, 2005;Final report 12/2014
available from CIRPEG/PPG-20/20 Dimethicone 1 IJT 24(Suppl.
1):1-102, 2005;Final report 12/2014
available from CIRPEG/PPG-20/22 Butyl Ether Dimethicone* 1 Final report 12/2014
available from CIRPEG/PPG-20/22 Methyl Ether Dimethicone* 1 Final report 12/2014
available from CIRPEG/PPG-20/23 Dimethicone 1 IJT 24(Suppl.
1):1-102, 2005;Final report 12/2014
available from CIRPEG/PPG-20/29 Dimethicone* 1 IJT 24(Suppl.
1):1-102, 2005;Final report 12/2014
available from CIRPEG/PPG-20/6 Dimethicone 1 JACT 1(4):33-54,
1982 confirmed02/03 IJT
24(S1):42-44, 2005;Final report 12/2014
available from CIRPEG/PPG-22/22 Butyl Ether Dimethicone* 1 Final report 12/2014
available from CIRPEG/PPG-22/23 Dimethicone 1 JACT 1(4):33 -54,
1982 confirmed02/03 IJT
24(S1):42-44, 2005;Final report 12/2014
available from CIRPEG/PPG-22/24 Dimethicone 1 IJT 24(Suppl.
1):1-102, 2005;Final report 12/2014
available from CIRPEG/PPG-22/40 Dimethyl Ether 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 09/2013
available from CIRPEG/PPG-23/23 Butyl Ether Dimethicone* 1 Final report 12/2014
available from CIRPEG/PPG-23/6 Dimethicone* 1 IJT 24(Suppl.
1):1-102, 2005;Final report 12/2014
available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
PEG/PPG-24/18 Butyl Ether Dimethicone* 1 Final report 12/2014available from CIR
PEG/PPG-25/25 Dimethicone 1 IJT 24(Suppl.1):1-102, 2005;
Final report 12/2014available from CIR
PEG/PPG-27/14 Dimethyl Ether 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2013available from CIR
PEG/PPG-27/27 Dimethicone* 1 IJT 24(Suppl.1):1-102, 2005;
Final report 12/2014available from CIR
PEG/PPG-27/9 Butyl Ether Dimethicone* 1 Final report 12/2014available from CIR
PEG/PPG-3/10 Dimethicone* 1 IJT 24(Suppl.1):1-102, 2005;
Final report 12/2014available from CIR
PEG/PPG-3/6 Dimethyl Ether 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2013available from CIR
PEG/PPG-30/10 Dimethicone 1 Final report 12/2014available from CIR
PEG/PPG-35/40 Dimethyl Ether 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2013available from CIR
PEG/PPG-36/41 Dimethyl Ether 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2013available from CIR
PEG/PPG-4/12 Dimethicone 1 JACT 1 (4):33-54,1982 confirmed
02/03 IJT24(S1):42-44, 2005;Final report 12/2014
available from CIRPEG/PPG-4/2 Propylheptyl Ether 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 09/2013
available from CIRPEG/PPG-40/2 Propylheptyl Ether 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 09/2013
available from CIRPEG/PPG-5/2 Methacrylate/Methacrylic Acid Crosspolymer 1 safe in the present practices of
use and concentration whennot polymerized in benzene
Final report 11/2011available from CIR
PEG/PPG-50/40 Dimethyl Ether 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2013available from CIR
PEG/PPG-52/32 Dimethyl Ether 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2013available from CIR
PEG/PPG-55/28 Dimethyl Ether 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2013available from CIR
PEG/PPG-6/11 Dimethicone* 1 IJT 24(Suppl.1):1-102, 2005;
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Final report 12/2014available from CIR
PEG/PPG-6/2 Propylheptyl Ether 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2013available from CIR
PEG/PPG-6/4 Dimethicone* 1 Final report 12/2014available from CIR
PEG/PPG-7/12 Dimethyl Ether 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2013available from CIR
PEG/PPG-8/14 Dimethicone 1 IJT 24(Suppl.1):1-102, 2005;
Final report 12/2014available from CIR
PEG/PPG-8/26 Dimethicone* 1 Final report 12/2014available from CIR
PEG/PPG-8/2 Propylheptyl Ether 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2013available from CIR
PEG/PPG-9/2 Dimethyl Ether 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2013available from CIR
PEG-10 1 0.1 to 0.2% Final report 06/10available from CIR
PEG-10/lauryl dimethicone crosspolymer 1 0.5 to 0.7% Final report 09/12available from CIR
PEG-100 1 not in current use* Final report 06/10available from CIR
PEG-100 castor oil 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
PEG-100 hydrogenated castor oil 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
PEG-100 Lanolin 1 concentration not reported* Final amended report09/12 available from
CIRPEG-100 Stearate 1 up to 6% IJT 24(S1):1-102,
2005PEG-100 Stearate 1 up to 25% JACT 2(7):17-60,
1983 confirmed11/02 IJT
24(S1):74-80, 2005PEG-10 castor oil 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014PEG-10 Cocamine* 1 safe as used when formulated
to be non-irritatingIJT 18(S1):11-31,1999; Final report06/2015 available
from CIRPEG-10 Dimethicone 1 JACT 1(4):33-54,
1982 confirmed02/03 IJT
24(S1):42-44, 2005;
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Final report 12/2014available from CIR
PEG-10 dimethicone/vinyl dimethicone crosspolymer 1 concentration not reported* Final report 09/12available from CIR
PEG-10 dimethicone crosspolymer 1 0.6 to 2% Final report 09/12available from CIR
PEG-10 dioleate* 1 safe when formulatedto be non-irritating
Final report 03/2015available from CIR
PEG-10 hydrogenated castor oil 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
PEG-10 hydrogenated castor oil isostearate 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
PEG-10 hydrogenated castor oil triisostearate 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
PEG-10 Hydrogenated Lanolin 1 not in current use* Final amended report09/12 available from
CIRPEG-10 hydrogenated tallow amine* 1 safe as used when formulated
to be non-irritatingFinal report 06/2015
available from CIRPEG-10 Lanolin 1 not in current use* Final amended report
09/12 available fromCIR
PEG-10 Laurate 1 up to 25% IJT 19(S2):29-41,2000
PEG-10 Methyl Ether Dimethicone 1 Final report 12/2014available from CIR
PEG-10 oleamine* 1 safe as used when formulatedto be non-irritating
Final report 06/2015available from CIR
PEG-10 Olive Glycerides 1 safe when formulatedto be non- irritating
Final report 12/2014available from CIR
PEG-10 Polydimethylsiloxyethyl Dimethicone/bis-vinylDimethicone Crosspolymer*
1 Final report 12/2014available from CIR
PEG-10 Propylene Glycol 1 not in current use* IJT 20(S4):13-26,2001
PEG-10 sorbitan laurate 1 safe as used when formulatedto be non-irritating
IJT 19 (S2):43-89,2000; Final report06/2015 available
from CIRPEG-10 soyamine* 1 safe as used when formulated
to be non-irritatingFinal report 06/2015
available from CIRPEG-10 Soy Sterol 1 up to 2% IJT 23(S2):23-47,
2004PEG-10 stearamine* 1 safe as used when formulated
to be non-irritatingFinal report 06/2015
available from CIRPEG-10 Sunflower Glycerides 1 safe when formulated
to be non- irritatingFinal report 12/2014
available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
PEG-10 Tsubakiate Glycerides* 1 safe when formulatedto be non- irritating
Final report 12/2014available from CIR
PEG-115M 1 not in current use* Final report 06/10available from CIR
PEG-11 Avocado Glycerides* 1 safe when formulatedto be non- irritating
Final report 12/2014available from CIR
PEG-11 Babassu Glycerides* 1 safe when formulatedto be non- irritating
Final report 12/2014available from CIR
PEG-11 castor oil 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
PEG-11 Cocoa Butter Glycerides* 1 safe when formulatedto be non- irritating
Final report 12/2014available from CIR
PEG-11 Methyl Ether Dimethicone 1 Final report 12/2014available from CIR
PEG-11 tallow amine* 1 safe as used when formulatedto be non-irritating
Final report 06/2015available from CIR
PEG-12 1 0.04 to 56% Final report 06/10available from CIR
PEG-120 distearate 1 safe when formulatedto be non-irritating
IJT 19(S1):51-59,1999; Final report03/2015 available
from CIRPEG-120 methyl glucose dioleate 1 Final report 09/2013
available from CIRPEG-120 methyl glucose triisostearate 1 Final report 09/2013
available from CIRPEG-120 methyl glucose trioleate 1 Final report 09/2013
available from CIRPEG-120 Propylene Glycol Stearate 1 not in current use* IJT 20(S4):13-26,
2001PEG-12 cocamine* 1 safe as used when formulated
to be non-irritatingFinal report 06/2015
available from CIRPEG-12 diisostearate 1 safe when formulated
to be non-irritatingFinal report 03/2015
available from CIRPEG-12 dilaurate* 1 safe when formulated
to be non-irritatingIJT 19(S2):29-41,2000; Final report03/2015 available
from CIRPEG-12 Dimethicone 1 JACT 1(4):33-54,
1982 confirmed02/03 IJT
24(S1):42-44, 2005;Final report 12/2014
available from CIRPEG-12 dimethicone/bis-isobutyl PPG-20 crosspolymer 1 not in current use* Final report 09/12
available from CIRPEG-12 dimethicone/PPG-20 crosspolymer 1 not in current use* Final report 09/12
available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
PEG-12 dimethicone crosspolymer 1 0.3 to 2% Final report 09/12available from CIR
PEG-12 Dioleate 1 safe when formulatedto be non-irritating
Final report 03/2015available from CIR
PEG-12 Distearate 1 safe when formulatedto be non-irritating
IJT 19(S1):51-59,1999; Final report03/2015 available
from CIRPEG-12 Ditallate* 1 safe when formulated
to be non-irritatingFinal report 03/2015
available from CIRPEG-12 Laurate 1 up to 25% IJT 19(S2):29-41,
2000PEG-12 palmitamine* 1 safe as used when formulated
to be non-irritatingFinal report 06/2015
available from CIRPEG-12 Palm Kernel Glycerides* 1 safe when formulated
to be non- irritatingFinal report 12/2014
available from CIRPEG-12 Stearate 1 up to 1% JACT 2(7):17-60,
1983 confirmed11/02 IJT
24(S1):74-80, 2005PEG-135 1 not in current use* Final report 06/10
available from CIRPEG-13 Mink Glycerides* 1 safe when formulated
to be non- irritatingFinal report 12/2014
available from CIRPEG-13 Sunflower Glycerides 1 safe when formulated
to be non- irritatingFinal report 12/2014
available from CIRPEG-14 1 0.1 to 2% Final report 06/10
available from CIRPEG-14 Avocado Glycerides* 1 safe when formulated
to be non- irritatingFinal report 12/2014
available from CIRPEG-14 Dimethicone 1 JACT 1(4):33-54,
1982 confirmed02/03 IJT
24(S1):42-44, 2005;Final report 12/2014
available from CIRPEG-14 Laurate 1 up to 25% IJT 19(S2):29-41,
2000PEG-14M 1 0.05 to 0.5% Final report 06/10
available from CIRPEG-15/lauryl dimethicone crosspolymer 1 0.7 to 2% Final report 09/12
available from CIRPEG-15/lauryl polydimethylsiloxyethyl dimethiconecrosspolymer
1 not in current use* Final report 09/12available from CIR
PEG-150 1 0.0009 to 6% Final report 06/10available from CIR
PEG-150 dibehenate* 1 safe when formulatedto be non-irritating
Final report 03/2015available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
PEG-150 dilaurate* 1 safe when formulatedto be non-irritating
IJT 19(S2):29-41,2000; Final report03/2015 available
from CIRPEG-150 dioleate* 1 safe when formulated
to be non-irritatingFinal report 03/2015
available from CIRPEG-150 distearate 1 safe when formulated
to be non-irritatingIJT 19(S1):51-59,1999; Final report03/2015 available
from CIRPEG-150 Lanolin 1 not in current use* Final amended report
09/12 available fromCIR
PEG-150 Laurate 1 up to 25% IJT 19(S2):29-41,2000
PEG-150 Pentaerythrityl Tetrastearate 1 Final report 06/2014available from CIR
PEG-150 Stearate 1 up to 6% IJT 24(S1):1-102,2005
PEG-15 castor oil 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
PEG-15 cocamine 1 safe as used when formulatedto be non-irritating
Final report 06/2015available from CIR
PEG-15 hydrogenated castor oil isostearate 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
PEG-15 hydrogenated castor oil triisostearate 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
PEG-15 Hydrogenated Lanolin 1 not in current use* Final amended report09/12 available from
CIRPEG-15 hydrogenated tallow amine* 1 safe as used when formulated
to be non-irritatingFinal report 06/2015
available from CIRPEG-15 Jojoba Alcohol 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 31(S2):169-244
(2012)PEG-15 oleamine* 1 safe as used when formulated
to be non-irritatingFinal report 06/2015
available from CIRPEG-15 soyamine* 1 safe as used when formulated
to be non-irritatingFinal report 06/2015
available from CIRPEG-15 stearamine* 1 safe as used when formulated
to be non-irritatingFinal report 06/2015
available from CIRPEG-15 tallow amine* 1 safe as used when formulated
to be non-irritatingFinal report 06/2015
available from CIRPEG-16 1 not in current use* Final report 06/10
available from CIRPEG-160M 1 not in current use* Final report 06/10
available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
PEG-160 Sorbitan Triisostearate 1 safe as used when formulatedto be non-irritating
IJT 19(S2):43-89,2000; Final report06/2015 available
from CIRPEG-16 castor oil 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014PEG-16 Cetyl/Oleyl/Stearyl/Lanolin Alcohol Ether 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 31(S2):169-244
(2012)PEG-16 dilaurate* 1 safe when formulated
to be non-irritatingFinal report 03/2015
available from CIRPEG-16 hydrogenated castor oil 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014PEG-16 Macadamia Glycerides 1 safe when formulated
to be non- irritatingFinal report 12/2014
available from CIRPEG-16 Soy Sterol 1 up to 0.5% IJT 23(S2):23- 47,
2004PEG-175 diisostearate 1 safe when formulated
to be non-irritatingFinal report 03/2015
available from CIRPEG-175 distearate 1 safe when formulated
to be non-irritatingIJT 19(S1):51-59,1999; Final report03/2015 available
from CIRPEG-17 Dimethicone 1 JACT 1(4):33-54,
1982 confirmed02/03 IJT
24(S1):42-44, 2005;Final report 12/2014
available from CIRPEG-18 1 not in current use* Final report 06/10
available from CIRPEG-180 1 0.05 to 5% Final report 06/10
available from CIRPEG-180M 1 0.05 to 0.08% Final report 06/10
available from CIRPEG-18 castor oil dioleate 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014PEG-18 Palm Glycerides* 1 safe when formulated
to be non- irritatingFinal report 12/2014
available from CIRPEG-18 sorbitan trioleate 1 safe as used when formulated
to be non-irritatingIJT 19(S2):43-89,2000; Final report06/2015 available
from CIRPEG-190 distearate* 1 safe when formulated
to be non-irritatingFinal report 03/2015
available from CIRPEG-192 Apricot Kernel Glycerides 1 safe when formulated
to be non- irritatingFinal report 12/2014
available from CIRPEG-20 1 0.02 to 27% Final report 06/10
available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
PEG-200 1 not in current use* Final report 06/10available from CIR
PEG-200 castor oil 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
PEG-200 hydrogenated castor oil 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
PEG-200 Laurate 1 up to 25% IJT 19(S2):29-41,2000
PEG-20 Almond Glycerides 1 safe when formulatedto be non- irritating
Final report 12/2014available from CIR
PEG-20 castor oil 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
PEG-20 cocamine* 1 safe as used when formulatedto be non-irritating
IJT 18(S1):11-31,1999; Final report06/2015 available
from CIRPEG-20 Corn Glycerides* 1 safe when formulated
to be non- irritatingFinal report 12/2014
available from CIRPEG-20 dilaurate* 1 safe when formulated
to be non-irritatingIJT 19(S2):29-41,2000; Final report03/2015 available
from CIRPEG-20 dioleate* 1 safe when formulated
to be non-irritatingFinal report 03/2015
available from CIRPEG-20 distearate* 1 safe when formulated
to be non-irritatingIJT 19(S1):51-59,1999; Final report03/2015 available
from CIRPEG-20 Evening Primrose Glycerides* 1 safe when formulated
to be non- irritatingFinal report 12/2014
available from CIRPEG-20 hydrogenated castor oil 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014PEG-20 hydrogenated castor oil isostearate 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014PEG-20 hydrogenated castor oil laurate 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014PEG-20 hydrogenated castor oil pca isostearate 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014PEG-20 hydrogenated castor oil triisostearate 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014PEG-20 Hydrogenated Lanolin 1 1.0 to 5.0% Final amended report
09/12 available fromCIR
PEG-20 Hydrogenated Palm Glycerides 1 safe when formulatedto be non- irritating
Final report 12/2014available from CIR
PEG-20 hydrogenated tallow amine* 1 safe as used when formulatedto be non-irritating
Final report 06/2015available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
PEG-20 Lanolin 1 not in current use* Final amended report09/12 available from
CIRPEG-20 Laurate 1 up to 25% IJT 19(S2):29-41,
2000PEG-20M 1 0.4 to 3% Final report 06/10
available from CIRPEG-20 methyl glucose distearate 1 Final report 09/2013
available from CIRPEG-20 methyl glucose sesquicaprylate/sesquicaprate 1 Final report 09/2013
available from CIRPEG-20 methyl glucose sesquilaurate 1 Final report 09/2013
available from CIRPEG-20 methyl glucose sesquistearate 1 Final report 09/2013
available from CIRPEG-20 oleamine* 1 safe as used when formulated
to be non-irritatingFinal report 06/2015
available from CIRPEG-20 Sorbitan Beeswax 1 up to 11% safe for use in the present
practices of use, exceptthat cosmetic fornulations
containing PEG-6, -20,and -75 should not be
used on damaged skin10
IJT 20(S4):27-38,2001
PEG-20 sorbitan cocoate 1 safe as used when formulatedto be non-irritating
IJT 19(S2):43-89,2000; Final report06/2015 available
from CIRPEG-20 sorbitan isostearate 1 safe as used when formulated
to be non-irritatingIJT 19(S2):43-89,2000; Final report06/2015 available
from CIRPEG-20 sorbitan oleate* 1 safe as used when formulated
to be non-irritatingFinal report 06/2015
available from CIRPEG-20 Sorbitan Tetraoleate 1 not in use at the time* IJT 19(S2):43-89,
2000PEG-20 sorbitan triisostearate* 1 safe as used when formulated
to be non-irritatingIJT 19(S2):43-89,2000; Final report06/2015 available
from CIRPEG-20 Stearate 1 up to 4% JACT 2(7):17-60,
1983 confirmed11/02 IJT
24(S1):74-80, 2005PEG-20 tallow amine* 1 safe as used when formulated
to be non-irritatingFinal report 06/2015
available from CIRPEG-20 Tsubakiate Glycerides* 1 safe when formulated
to be non- irritatingFinal report 12/2014
available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
PEG-220 1 0.3 to 0.4% Final report 06/10available from CIR
PEG-22 tallow amine* 1 safe as used when formulatedto be non-irritating
Final report 06/2015available from CIR
PEG-23M 1 0.05% Final report 06/10available from CIR
PEG-240 1 4 to 10% Final report 06/10available from CIR
PEG-24 Hydrogenated Lanolin 1 0.2 to 0.3% Final amended report09/12 available from
CIRPEG-24 Lanolin 1 not in current use* Final amended report
09/12 available fromCIR
PEG-250 distearate 1 safe when formulatedto be non-irritating
Final report 03/2015available from CIR
PEG-25 castor oil 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
PEG-25 hydrogenated castor oil 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
PEG-25 Lanolin 1 not in current use* Final amended report09/12 available from
CIRPEG-25M 1 not in current use* Final report 06/10
available from CIRPEG-25 Moringa Glycerides* 1 safe when formulated
to be non- irritatingFinal report 12/2014
available from CIRPEG-25 oleamine* 1 safe as used when formulated
to be non-irritatingFinal report 06/2015
available from CIRPEG-25 Propylene Glycol Stearate 1 1 to 5% IJT 20(S4):13-26,
2001PEG-25 Soy Sterol 1 up to 2% IJT 23(S2):23-47,
2004PEG-25 tallow amine* 1 safe as used when formulated
to be non-irritatingFinal report 06/2015
available from CIRPEG-26 castor oil 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014PEG-26 Jojoba Alcohol 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 31(S2):169-244
(2012)PEG-27 Lanolin 1 not in current use* Final amended report
09/12 available fromCIR
PEG-29 castor oil 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
PEG-2 castor oil 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
PEG-2 cocamine 1 safe as used when formulatedto be non-irritating
IJT 18(S1):11-31,1999; Final report06/2015 available
from CIRPEG-2 diisononanoate 1 safe when formulated
to be non-irritatingIJT 30(S3):228-269,
2011; Final report03/2015 available
from CIRPEG-2 diisostearate* 1 safe when formulated
to be non-irritatingFinal report 03/2015
available from CIRPEG-2 Dilaurate* 1 safe when formulated
to be non-irritatingIJT 19(S2):29-41,2000; Final report03/2015 available
from CIRPEG-2 dioleate* 1 safe when formulated
to be non-irritatingFinal report 03/2015
available from CIRPEG-2 distearate 1 safe when formulated
to be non-irritatingIJT 19(S1):51-59,1999; Final report03/2015 available
from CIRPEG-2 hydrogenated castor oil 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014PEG-2 hydrogenated tallow amine* 1 safe as used when formulated
to be non-irritatingFinal report 06/2015
available from CIRPEG-2 lauramine* 1 safe as used when formulated
to be non-irritatingFinal report 06/2015
available from CIRPEG-2 Laurate 1 up to 25% IJT 19(S2):29-41,
2000PEG-2 Laurate SE 1 up to 25% IJT 19(S2):29-41,
2000PEG-2M 1 0.5% Final report 06/10
available from CIRPEG-2 oleamine 1 safe as used when formulated
to be non-irritatingFinal report 06/2015
available from CIRPEG-2 Olive Glycerides* 1 safe when formulated
to be non- irritatingFinal report 12/2014
available from CIRPEG-2 rapseedamine 1 safe as used when formulated
to be non-irritatingFinal report 06/2015
available from CIRPEG-2 sorbitan isostearate* 1 safe as used when formulated
to be non-irritatingIJT 19(S2):43-89,2000; Final report06/2015 available
from CIRPEG-2 sorbitan trioleate* 1 safe as used when formulated
to be non-irritatingFinal report 06/2015
available from CIRPEG-2 soyamine 1 safe as used when formulated
to be non-irritatingFinal report 06/2015
available from CIRPEG-2 stearamine* 1 safe as used when formulated
to be non-irritatingFinal report 06/2015
available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
PEG-2 Stearate 1 up to 2% JACT 2(7):17-60,1983 confirmed
11/02 IJT24(S1):74-80, 2005
PEG-2 Sunflower Glycerides* 1 safe when formulatedto be non- irritating
Final report 12/2014available from CIR
PEG-2 tallow amine 1 safe as used when formulatedto be non-irritating
Final report 06/2015available from CIR
PEG-30 castor oil 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 16(S3):269-306,1997; IJT
33(S4):13-39, 2014PEG-30 Glyceryl Cocoate 1 safe when formulated
to be non- irritatingIJT 19(S1):51-59,1999; Final report12/2014 available
from CIRPEG-30 Hydrogenated Castor Oil 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 16(S3):269-306,
1997; IJT33(S4):13-39, 2014
PEG-30 Hydrogenated Castor Oil Isostearate 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
PEG-30 Hydrogenated Castor Oil Laurate 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
PEG-30 Hydrogenated Castor Oil PCA Isostearate 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
PEG-30 Hydrogenated Castor Oil Triisostearate 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
PEG-30 Hydrogenated Lanolin 1 not in current use* IJT 18(S1):61-68,1999; Final amended
report 09/12 availablefrom CIR
PEG-30 hydrogenated tallow amine* 1 safe as used when formulatedto be non-irritating
Final report 06/2015available from CIR
PEG-30 Lanolin 1 0.50% JACT 1(4):91-102,1982; Final amended
report 09/12 availablefrom CIR
PEG-30 oleamine* 1 safe as used when formulatedto be non-irritating
Final report 06/2015available from CIR
PEG-30 sorbitan beeswax 1 safe as used when formulatedto be non-irritating
Final report 06/2015available from CIR
PEG-30 sorbitan tetraoleate 1 safe as used when formulatedto be non-irritating
IJT 19(S2):43-89,2000; Final report06/2015 available
from CIRPEG-30 Sorbitol Tetraoleate Laurate (aka SorbethTetraoleate Laurate)
0 concentration not reported* IJT 19(S2):43-89,2000
PEG-30 Soy Sterol 1 not in current use* IJT 23(S2):23-47,2004
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
PEG-30 tallow amine* 1 safe as used when formulatedto be non-irritating
Final report 06/2015available from CIR
PEG-32 1 0.03 to 15% Final report 06/10available from CIR
PEG-32 dilaurate* 1 safe when formulatedto be non-irritating
IJT 19(S2):29-41,2000; Final report03/2015 available
from CIRPEG-32 dioleate* 1 safe when formulated
to be non-irritatingFinal report 03/2015
available from CIRPEG-32 distearate* 1 safe when formulated
to be non-irritatingIJT 19(S1):51-59,1999; Final report03/2015 available
from CIRPEG-32 Laurate 1 up to 25% IJT 19(S2):29-41,
2000PEG-32 Methyl Ether Dimethicone 1 Final report 12/2014
available from CIRPEG-32 Stearate 1 up to 6% IJT 24(S1):1-102,
2005PEG-33 1 not in current use* Final report 06/10
available from CIRPEG-33 castor oil 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014PEG-350 1 1% Final report 06/10
available from CIRPEG-35 Almond Glycerides* 1 safe when formulated
to be non- irritatingFinal report 12/2014
available from CIRPEG-35 castor oil 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014PEG-35 hydrogenated castor oil 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014PEG-35 Lanolin 1 not in current use* Final amended report
09/12 available fromCIR
PEG-35 Soy Glycerides 1 safe when formulatedto be non- irritating
Final report 12/2014available from CIR
PEG-36 castor oil 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
PEG-3 castor oil 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
PEG-3 cocamine* 1 safe as used when formulatedto be non-irritating
IJT 18(S1):11-31,1999; Final report06/2015 available
from CIRPEG-3 dicaprylate/caprate* 1 safe when formulated
to be non-irritatingFinal report 03/2015
available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
PEG-3 diisostearate* 1 safe when formulatedto be non-irritating
Final report 03/2015available from CIR
PEG-3 Dimethicone 1 JACT 1 (4):33-54,1982 confirmed
02/03 IJT24(S1):42-44, 2005;Final report 12/2014
available from CIRPEG-3 dioleate* 1 safe when formulated
to be non-irritatingFinal report 03/2015
available from CIRPEG-3 dipalmitate* 1 safe when formulated
to be non-irritatingFinal report 03/2015
available from CIRPEG-3 distearate 1 safe when formulated
to be non-irritatingIJT 19(S1):51-59,1999; Final report03/2015 available
from CIRPEG-3 Glyceryl Cocoate 1 safe when formulated
to be non- irritatingFinal report 12/2014
available from CIRPEG-3 Methyl Ether 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 31(S2):169-244
(2012)PEG-3 sorbitan oleate 1 safe as used when formulated
to be non-irritatingIJT 19(S2):43-89,2000; Final report06/2015 available
from CIRPEG-3 sorbitan stearate 1 safe as used when formulated
to be non-irritatingIJT 19(S2):43-89,2000; Final report06/2015 available
from CIRPEG-3 sorbitan tristearate* 1 safe as used when formulated
to be non-irritatingFinal report 06/2015
available from CIRPEG-4 1 0.01 to 67% Final report 06/10
available from CIRPEG-40 1 0.001 to 6% Final report 06/10
available from CIRPEG-400 1 1 to 3% Final report 06/10
available from CIRPEG-40 and -50 Sorbitol Hexaoleate (aka Sorbeth-40 and -50Hexaoleate)
0 concentration not reported* IJT 19(S2):43-89,2000
PEG-40 castor oil 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
PEG-40 distearate* 1 safe when formulatedto be non-irritating
Final report 03/2015available from CIR
PEG-40 Glyceryl Cocoate 1 safe when formulatedto be non- irritating
IJT 19(S1):51-59,1999; Final report12/2014 available
from CIR
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
PEG-40 Hydrogenated Castor Oil 1 safe for use in cosmeticswhen formulated tobe none-irritating
IJT 16(S3):269-306,1997; IJT
33(S4):13-39, 2014PEG-40 hydrogenated castor oil isostearate 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014PEG-40 hydrogenated castor oil laurate 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014PEG-40 hydrogenated castor oil pca isostearate 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014PEG-40 hydrogenated castor oil triisostearate 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014PEG-40 Hydrogenated Lanolin 1 not in current use* Final amended report
09/12 available fromCIR
PEG-40 hydrogenated tallow amine* 1 safe as used when formulatedto be non-irritating
Final report 06/2015available from CIR
PEG-40 Jojoba Alcohol 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
PEG-40 Lanolin 1 0.25% Final amended report09/12 available from
CIRPEG-40 Olive Glycerides* 1 safe when formulated
to be non- irritatingFinal report 12/2014
available from CIRPEG-40 sorbitan diisostearate 1 safe as used when formulated
to be non-irritatingIJT 19(S2):43-89,2000; Final report06/2015 available
from CIRPEG-40 sorbitan lanolate 1 safe as used when formulated
to be non-irritatingIJT 19 (S2):43-89,2000; Final report06/2015 available
from CIRPEG-40 sorbitan laurate 1 safe as used when formulated
to be non-irritatingIJT 19(S2):43-89,2000; Final report06/2015 available
from CIRPEG-40 sorbitan oleate* 1 safe as used when formulated
to be non-irritatingFinal report 06/2015
available from CIRPEG-40 sorbitan perisostearate* 1 safe as used when formulated
to be non-irritatingIJT 19(S2):43-89,2000; Final report06/2015 available
from CIRPEG-40 sorbitan peroleate 1 safe as used when formulated
to be non-irritatingIJT 19 (S2):43-89,2000; Final report06/2015 available
from CIRPEG-40 sorbitan stearate 1 safe as used when formulated
to be non-irritatingIJT 19(S2):43-89,2000; Final report
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
06/2015 availablefrom CIR
PEG-40 sorbitan tetraoleate 1 safe as used when formulatedto be non-irritating
IJT 19(S2):43-89,2000; Final report06/2015 available
from CIRPEG-40 Soy Sterol 1 not in current use* IJT 23 (S2):23-47,
2004PEG-40 Stearate 1 up to 7% JACT 2(7):17-60,
1983 confirmed11/02 IJT
24(S1):74-80, 2005PEG-42 Babassu Glycerides* 1 safe when formulated
to be non- irritatingFinal report 12/2014
available from CIRPEG-42 Mushroom Glycerides* 1 safe when formulated
to be non- irritatingFinal report 12/2014
available from CIRPEG-44 castor oil 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014PEG-44 sorbitan laurate 1 safe as used when formulated
to be non-irritatingIJT 19 (S2):43-89,2000; Final report06/2015 available
from CIRPEG-45 1 not in current use* Final report 06/10
available from CIRPEG-450 1 1% Final report 06/10
available from CIRPEG-45 hydrogenated castor oil 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014PEG-45M 1 0.03 to 0.3% Final report 06/10
available from CIRPEG-45 Palm Kernel Glycerides 1 safe when formulated
to be non- irritatingFinal report 12/2014
available from CIRPEG-45 Safflower Glycerides* 1 safe when formulated
to be non- irritatingFinal report 12/2014
available from CIRPEG-4 Caprylic/capric Glycerides* 1 safe when formulated
to be non- irritatingFinal report 12/2014
available from CIRPEG-4 castor oil 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014PEG-4 cocamine* 1 safe as used when formulated
to be non-irritatingFinal report 06/2015
available from CIRPEG-4 dicocoate* 1 safe when formulated
to be non-irritatingFinal report 03/2015
available from CIRPEG-4 diheptanoate 1 safe when formulated
to be non-irritatingFinal report 03/2015
available from CIRPEG-4 diisostearate* 1 safe when formulated
to be non-irritatingFinal report 03/2015
available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
PEG-4 Dilaurate 1 safe when formulatedto be non-irritating
IJT 19(S2):29-41,2000; Final report03/2015 available
from CIRPEG-4 Dimethacrylate 1 safe in nail enhancement
products when skin contact isavoided; products containing
this ingredient should beaccompanied with directions
to avoid skin contactbecause of the sensitizingpotential of methacrylates
IJT 24(S5):53-100,2005
PEG-4 dioleate* 1 safe when formulatedto be non-irritating
Final report 03/2015available from CIR
PEG-4 distearate 1 safe when formulatedto be non-irritating
IJT 19(S1):51-59,1999; Final report03/2015 available
from CIRPEG-4 Distearyl Ether 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 31(S2):169-244
(2012)PEG-4 Ditallow Ether 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 31(S2):169-244
(2012)PEG-4 Laurate 1 up to 25% IJT 19(S2):29-41,
2000PEG-4 Methyl Ether 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 31(S2):169-244
(2012)PEG-4 PEG-12 Dimethicone* 1 Final report 12/2014
available from CIRPEG-4-PPG-7 C13/C15 Alcohol 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 09/2013
available from CIRPEG-4 sorbitan stearate* 1 safe as used when formulated
to be non-irritatingFinal report 06/2015
available from CIRPEG-4 sorbitan triisostearate* 1 safe as used when formulated
to be non-irritatingFinal report 06/2015
available from CIRPEG-500 1 not in current use* Final report 06/10
available from CIRPEG-50 castor oil 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014PEG-50 distearate 1 safe when formulated
to be non-irritatingIJT 19(S1):51-59,1999; Final report03/2015 available
from CIRPEG-50 hydrogenated castor oil 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014PEG-50 hydrogenated castor oil isostearate 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014PEG-50 hydrogenated castor oil laurate 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
PEG-50 hydrogenated castor oil succinate 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
PEG-50 hydrogenated castor oil triisostearate 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
PEG-50 hydrogenated tallow amine* 1 safe as used when formulatedto be non-irritating
Final report 06/2015available from CIR
PEG-50 Lanolin 1 concentration not reported* Final amended report09/12 available from
CIRPEG-50 stearamine* 1 safe as used when formulated
to be non-irritatingFinal report 06/2015
available from CIRPEG-50 Stearate 1 up to 9% JACT 2(7):17-60,
1983 confirmed11/02 IJT
24(S1):74-80, 2005PEG-54 castor oil 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014PEG-54 hydrogenated castor oil 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014PEG-55 1 not in current use* Final report 06/10
available from CIRPEG-55 castor oil 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014PEG-55 hydrogenated castor oil 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014PEG-55 Lanolin 1 not in current use* Final amended report
09/12 available fromCIR
PEG-55 Propylene Glycol Oleate 1 up to 10% IJT 20(S4):13-26,2001
PEG-58 hydrogenated castor oil isostearate 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
PEG-5 castor oil 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
PEG-5 cocamine 1 safe as used when formulatedto be non-irritating
Final report 06/2015available from CIR
PEG-5 hydrogenated castor oil 1 safe for use in cosmetics whenformulated to be non-irritating
Final amended report09/12 available from
CIRPEG-5 hydrogenated castor oil isostearate 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014PEG-5 hydrogenated castor oil triisostearate 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014PEG-5 Hydrogenated Corn Glycerides* 1 safe when formulated
to be non- irritatingFinal report 12/2014
available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
PEG-5 Hydrogenated Lanolin 1 not in current use* Final amended report09/12 available from
CIRPEG-5 hydrogenated tallow amine 1 safe as used when formulated
to be non-irritatingFinal report 06/2015
available from CIRPEG-5 Isononanoate 1 1% Final report 06/10
available from CIRPEG-5 Lanolin 1 concentration not reported* Final amended report
09/12 available fromCIR
PEG-5M 1 0.01% Final report 06/10available from CIR
PEG-5 oleamine* 1 safe as used when formulatedto be non-irritating
Final report 06/2015available from CIR
PEG-5 sorbitan isostearate* 1 safe as used when formulatedto be non-irritating
IJT 19(S2):43-89,2000; Final report06/2015 available
from CIRPEG-5 soyamine 1 safe as used when formulated
to be non-irritatingFinal report 06/2015
available from CIRPEG-5 Soy Sterol 1 up to 2% IJT 23(S2):23-47,
2004PEG-5 stearamine* 1 safe as used when formulated
to be non-irritatingFinal report 06/2015
available from CIRPEG-5 Tsubakiate Glycerides* 1 safe when formulated
to be non- irritatingFinal report 12/2014
available from CIRPEG-6 1 0.01 to 51% Final report 06/10
available from CIRPEG-60 1 not in current use* Final report 06/10
available from CIRPEG-60 Almond Glycerides 1 safe when formulated
to be non- irritatingFinal report 12/2014
available from CIRPEG-60 castor oil 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014PEG-60 castor oil isostearate 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014PEG-60 castor oil isostearate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal amended report09/12 available from
CIRPEG-60 Corn Glycerides* 1 safe when formulated
to be non- irritatingFinal report 12/2014
available from CIRPEG-60 Evening Primrose Glycerides* 1 safe when formulated
to be non- irritatingFinal report 12/2014
available from CIRPEG-60 hydrogenated castor oil 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014PEG-60 hydrogenated castor oil laurate 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
PEG-60 hydrogenated castor oil pca isostearate 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
PEG-60 Hydrogenated Castor Oil Triisostearate 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
PEG-60 Lanolin 1 0.4 to 2% Final amended report09/12 available from
CIRPEG-60 Passiflora Edulis Seed Glycerides* 1 safe when formulated
to be non-irritatingFinal report 12/2014
available from CIRPEG-60 Passiflora Incarnata Seed Glycerides* 1 safe when formulated
to be non-irritatingFinal report 12/2014
available from CIRPEG-60 Shea Butter Glycerides 1 safe when formulated
to be non- irritatingFinal report 12/2014
available from CIRPEG-60 sorbitan stearate* 1 safe as used when formulated
to be non-irritatingIJT 19(S2):43-89,2000; Final report06/2015 available
from CIRPEG-60 sorbitan tetraoleate 1 safe as used when formulated
to be non-irritatingIJT 19(S2):43-89,2000; Final report06/2015 available
from CIRPEG-60 sorbitan tetrastearate* 1 safe as used when formulated
to be non-irritatingIJT 19(S2):43-89,2000; Final report06/2015 available
from CIRPEG-60 Sorbitol Tetrastearate (aka Sorbeth Tetrastearate) 0 concentration not reported* IJT 19(S2):43-89,
2000PEG-60 Tsubakiate Glycerides* 1 safe when formulated
to be non- irritatingFinal report 12/2014
available from CIRPEG-65 hydrogenated castor oil 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014PEG-65M 1 not in current use* Final report 06/10
available from CIRPEG-6 Almond Glycerides* 1 safe when formulated
to be non- irritatingFinal report 12/2014
available from CIRPEG-6 Caprylic/capric Glycerides 1 safe when formulated
to be non- irritatingFinal report 12/2014
available from CIRPEG-6 diisostearate 1 safe when formulated
to be non-irritatingFinal report 03/2015
available from CIRPEG-6 dilaurate* 1 safe when formulated
to be non-irritatingIJT 19(S2):29-41,2000; Final report03/2015 available
from CIRPEG-6 Dimethicone* 1 Final report 12/2014
available from CIRPEG-6 dioleate* 1 safe when formulated
to be non-irritatingFinal report 03/2015
available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
PEG-6 distearate 1 safe when formulatedto be non-irritating
IJT 19(S1):51-59,1999; Final report03/2015 available
from CIRPEG-6 hydrogenated castor oil 1 safe for use in cosmetics when
formulated to be non-irritatingFinal amended report09/12 available from
CIRPEG-6 Hydrogenated Palm/palm Kernel Glyceride* 1 safe when formulated
to be non-irritatingIJT 33(S4):13-39,
2014PEG-6 Laurate 1 up to 25% IJT 19(S2):29-41,
2000PEG-6 Methyl Ether 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 31(S2):169-244
(2012)PEG-6 Methyl Ether Dimethicone 1 Final report 12/2014
available from CIRPEG-6 oleamine* 1 safe as used when formulated
to be non-irritatingFinal report 06/2015
available from CIRPEG-6 Olive Glycerides* 1 safe when formulated
to be non- irritatingFinal report 12/2014
available from CIRPEG-6 Sorbitan Beeswax 1 not in current use* safe for use in the present
practices of use, exceptthat cosmetic fornulations
containing PEG-6, -20,and -75 should not be
used on damaged skin10
IJT 20 (S4):27-38,2001
PEG-6 sorbitan oleate 1 safe as used when formulatedto be non-irritating
Final report 06/2015available from CIR
PEG-6 Sorbitan Oleate 1 not in use at the time* IJT 19(S2):43-89,2000
PEG-6 sorbitan stearate 1 safe as used when formulatedto be non-irritating
Final report 06/2015available from CIR
PEG-6 Sorbitan Stearate 1 not in use at the time* IJT 19(S2):43-89,2000
PEG-6 Stearate 1 up to 6% IJT 24(S1):1-102,2005
PEG-7 1 not in current use* Final report 06/10available from CIR
PEG-7/PPG-2 Propylheptyl Ether 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2013available from CIR
PEG-70 Hydrogenated Lanolin 1 not in current use* Final amended report09/12 available from
CIRPEG-70 Lanolin 1 not in current use* Final amended report
09/12 available fromCIR
PEG-70 Lanolin 1 Final amended report09/12 available from
CIR
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
PEG-70 Mango Glycerides 1 safe when formulatedto be non- irritating
Final report 12/2014available from CIR
PEG-75 1 0.2 to 36% Final report 06/10available from CIR
PEG-75 castor oil 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
PEG-75 Cocoa Butter Glycerides 1 safe when formulatedto be non- irritating
Final report 12/2014available from CIR
PEG-75 crambe abyssinica seed oil 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
PEG-75 dilaurate* 1 safe when formulatedto be non-irritating
IJT 19(S2):29-41,2000; Final report03/2015 available
from CIRPEG-75 dioleate* 1 safe when formulated
to be non-irritatingFinal report 03/2015
available from CIRPEG-75 distearate* 1 safe when formulated
to be non-irritatingIJT 19 (S1):51-59,1999; Final report03/2015 available
from CIRPEG-75 Lanolin 1 0.001 to 15% Final amended report
09/12 available fromCIR
PEG-75 Lanolin 1 Final amended report09/12 available from
CIRPEG-75 Lanolin Oil 1 concentration not reported* Final amended report
09/12 available fromCIR
PEG-75 Lanolin Wax 1 not in current use* Final amended report09/12 available from
CIRPEG-75 Laurate 1 up to 25% IJT 19(S2):29-41,
2000PEG-75 meadowfoam oil 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014PEG-75 Propylene Glycol Stearate 1 not in current use* IJT 20(S4):13-26,
2001PEG-75 Shea Butter Glycerides 1 safe when formulated
to be non- irritatingFinal report 12/2014
available from CIRPEG-75 Shorea Butter Glycerides* 1 safe when formulated
to be non- irritatingFinal report 12/2014
available from CIRPEG-75 sorbitan lanolate* 1 safe as used when formulated
to be non-irritatingIJT 19 (S2):43-89,2000; Final report06/2015 available
from CIRPEG-75 sorbitan laurate 1 safe as used when formulated
to be non-irritatingIJT 19 (S2):43-89,2000; Final report
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
06/2015 availablefrom CIR
PEG-75 Soy Glycerides* 1 safe when formulatedto be non- irritating
Final report 12/2014available from CIR
PEG-78 Glyceryl Cocoate* 1 safe when formulatedto be non- irritating
IJT 19(S1):51-59,1999; Final report12/2014 available
from CIRPEG-7 Caprylic/capric Glycerides 1 safe when formulated
to be non- irritatingFinal report 12/2014
available from CIRPEG-7 Cocoglycerides* 1 safe when formulated
to be non- irritatingFinal report 12/2014
available from CIRPEG-7 Dimethicone 1 JACT 1(4):33-54,
1982 confirmed02/03 IJT
24(S1):42-44, 2005;Final report 12/2014
available from CIRPEG-7 Glyceryl Cocoate 1 safe when formulated
to be non- irritatingIJT 19(S1):51-59,1999; Final report12/2014 available
from CIRPEG-7 hydrogenated castor oil 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014PEG-7M 1 0.05 to 0.5% Final report 06/10
available from CIRPEG-7 Methyl Ether 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 31(S2):169-244
(2012)PEG-7 Methyl Ether Dimethicone* 1 Final report 12/2014
available from CIRPEG-7 Olive Glycerides* 1 safe when formulated
to be non- irritatingFinal report 12/2014
available from CIRPEG-7 Propylheptyl Ether 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 31(S2):169-244
(2012)PEG-7 Sunflower Glycerides* 1 safe when formulated
to be non- irritatingFinal report 12/2014
available from CIRPEG-7 tallow amine* 1 safe as used when formulated
to be non-irritatingFinal report 06/2015
available from CIRPEG-8 1 0.0002 to 85% Final report 06/10
available from CIRPEG-80 1 not in current use* Final report 06/10
available from CIRPEG-800 1 not in current use* Final report 06/10
available from CIRPEG-80 castor oil 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014PEG-80 Glyceryl Cocoate 1 safe when formulated
to be non- irritatingIJT 19(S1):51-59,1999; Final report
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
12/2014 availablefrom CIR
PEG-80 hydrogenated castor oil 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
PEG-80 methyl glucose laurate 1 not in current use* Final report 09/2013available from CIR
PEG-80 sorbitan laurate 1 safe as used when formulatedto be non-irritating
IJT 19(S2):43-89,2000; Final report06/2015 available
from CIRPEG-80 sorbitan palmitate* 1 safe as used when formulated
to be non-irritatingIJT 19(S2):43-89,2000; Final report06/2015 available
from CIRPEG-85 Lanolin 1 JACT 1(4):91-102,
1982; Final amendedreport 09/12 available
from CIRPEG-8 Caprylic/capric Glycerides 1 safe when formulated
to be non- irritatingFinal report 12/2014
available from CIRPEG-8 castor oil 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014PEG-8 Cetyl Dimethicone 1 Final report 12/2014
available from CIRPEG-8 cocamine* 1 safe as used when formulated
to be non-irritatingFinal report 06/2015
available from CIRPEG-8 dicocoate 1 safe when formulated
to be non-irritatingFinal report 03/2015
available from CIRPEG-8 diisostearate 1 safe when formulated
to be non-irritatingFinal report 03/2015
available from CIRPEG-8 dilaurate 1 safe when formulated
to be non-irritatingIJT 19(S2):29-41,2000; Final report03/2015 available
from CIRPEG-8 Dimethicone 1 JACT 1(4):33-54,
1982 confirmed02/03 IJT
24(S1):42-44, 2005;Final report 12/2014
available from CIRPEG-8 Dimethicone/dimer Dilinoleic Acid Copolymer 1 Final report 12/2014
available from CIRPEG-8 dimethicone/polysorbate 20 crosspolymer 1 not in current use* IJT 33 (S2): 65-115,
2014PEG-8 Dimethicone Dimer Dilinoleate* 1 Final report 12/2014
available from CIRPEG-8 dioleate 1 safe when formulated
to be non-irritatingFinal report 03/2015
available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
PEG-8 distearate 1 safe when formulatedto be non-irritating
IJT 19(S1):51-59,1999; Final report03/2015 available
from CIRPEG-8 ditallate* 1 safe when formulated
to be non-irritatingFinal report 03/2015
available from CIRPEG-8 hydrogenated castor oil 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014PEG-8 Hydrogenated Fish Glycerides* 1 safe when formulated
to be non- irritatingFinal report 12/2014
available from CIRPEG-8 hydrogenated tallow amine 1 safe as used when formulated
to be non-irritatingFinal report 06/2015
available from CIRPEG-8 Laurate 1 up to 25% IJT 19(S2):29-41,
2000PEG-8 Methicone 1 Final report 12/2014
available from CIRPEG-8 Methyl Ether Dimethicone* 1 Final report 12/2014
available from CIRPEG-8 PEG-4 Dimethicone* 1 Final report 12/2014
available from CIRPEG-8 PPG-8 Dimethicone* 1 Final report 12/2014
available from CIRPEG-8 Propylene Glycol Cocoate 1 1 to 5% IJT 20(S4):13-26,
2001PEG-8 Propylheptyl Ether 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 31(S2):169-244
(2012)PEG-8 Sorbitan Beeswax 1 not in current use* safe for use in the present
practices of use, exceptthat cosmetic fornulations
containing PEG-6, -20,and -75 should not be
used on damaged skin11
IJT 20(S4):27-38,2001
PEG-8 soyamine* 1 safe as used when formulatedto be non-irritating
Final report 06/2015available from CIR
PEG-8 Stearate 1 up to 3% JACT 2(7):17-60,1983 confirmed
11/02 IJT24(S1):74-80, 2005
PEG-9 1 0.02 to 0.9% Final report 06/10available from CIR
PEG-90 1 0.05 to 21% Final report 06/10available from CIR
PEG-90 diisostearate 1 safe when formulatedto be non-irritating
Final report 03/2015available from CIR
PEG-90M 1 0.0002 to 0.3% Final report 06/10available from CIR
PEG-9 castor oil 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
PEG-9 Cocoglycerides* 1 safe when formulatedto be non- irritating
Final report 12/2014available from CIR
PEG-9 Dimethicone 1 JACT 1(4):33-54,1982 confirmed
02/03 IJT24(S1):42-44, 2005;Final report 12/2014
available from CIRPEG-9 distearate* 1 safe when formulated
to be non-irritatingIJT 19 (S1):51-59,1999; Final report03/2015 available
from CIRPEG-9 Laurate 1 up to 25% IJT 19(S2):29-41,
2000PEG-9M 1 not in current use* Final report 06/10
available from CIRPEG-9 Methyl Ether Dimethicone* 1 Final report 12/2014
available from CIRPEG-9 Polydimethylsiloxyethyl Dimethicone 1 Final report 12/2014
available from CIRPEG-Cetyl Stearyl Diether 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 31(S2):169-244
(2012)PEGgreater than or equal to4 0 because PEGs of various
chain lengths are likely tobe added to the International
Cosmetic IngredientDictionary and Handbook
in the future, the CIRExpert Panel concluded
that any PEG greater thanor equal to 4 would be
safe for use in cosmetics
Final report 06/10available from CIR
Pelargonic Acid 1 not in use at the time* IJT 30(S3):228-269,2011
Pentaerythrityl Cocoate (amended) 1 concentration not reported* IJT 30(S1):5S-16SPentaerythrityl Rosinate 1 JACT 13(5):395-399,
1994; IJT17(S4):83-94, 1998
Pentaerythrityl Tetrabehenate 1 2 to 3% Final report 12/11available from CIR
Pentaerythrityl Tetrabehenate/Benzoate/Ethylhexanoate 1 0.5 to 16% Final report 12/11available from CIR
Pentaerythrityl Tetrabenzoate 1 not in use at the time* Final report 12/11available from CIR
Pentaerythrityl Tetra C5-10 Acid Esters 1 not in use at the time* Final report 12/11available from CIR
Pentaerythrityl Tetra C5-9 Acid Esters 1 not in use at the time* Final report 12/11available from CIR
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Pentaerythrityl Tetracaprylate/Tetracaprate 1 0.07 to 5% Final report 12/11available from CIR
Pentaerythrityl Tetracocoate 1 not in use at the time* Final report 12/11available from CIR
Pentaerythrityl Tetra-Di-t-Butyl Hydroxyhydrocinnamate 1 0.00001- 0.8% Final report 03/2014available from CIR
Pentaerythrityl Tetraethylhexanoate 1 0.06 to 50% Final report 12/11available from CIR
Pentaerythrityl Tetraethylhexanoate/Benzoate 1 40% Final report 12/11available from CIR
Pentaerythrityl Tetraisononanoate 1 not in use at the time* Final report 12/11available from CIR
Pentaerythrityl Tetraisostearate 1 0.1 to 55% Final report 12/11available from CIR
Pentaerythrityl Tetramyristate 1 not in use at the time* Final report 12/11available from CIR
Pentaerythrityl Tetraoleate 1 not in use at the time* Final report 12/11available from CIR
Pentaerythrityl Tetrapelargonate 1 2% Final report 12/11available from CIR
Pentaerythrityl Tetrastearate 1 7% Final report 12/11available from CIR
Pentasodium Pentetate 1 up to 3% IJT 27 (S2): 71-92,2008
Pentetic Acid 1 up to 0.03% IJT 27 (S2): 71-92,2008
Pentylene Glycol 1 0.001 to 5% IJT 31 (S2): 147-168,2012
Perfluorononyl dimethicone/methicone/amodimethiconecrosspolymer
1 0.70% IJT 33 (S2): 65-115,2014
Perilla Ocymoides Seed Oil 1 concentration not reported* Final report 03/11available from CIR
Persea Gratissima (Avocado) Butter 1 concentration not reported* Final report 03/11Available from CIR
Persea Gratissima (Avocado) Oil 1 0.0001 to 98% Final amended report03/11 available
from CIR; JEPT4(4):93-103, 1980
(original) re-reviewIJT 22(S1):1-35,
2003Persea Gratissima (Avocado) Oil Unsaponifiables 1 0.2 to 6% Final report 03/11
available from CIRPersea Gratissima (Avocado) Sterols 1 Final report 12/2013
available from CIR
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Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Petroleum Distillates (aka Petroleum Distillate) 1 up to 82% JACT 5(3):225-248,1986 confirmed
12/06Phaseolus Angularis Seed Starch 1 Final report 09/2015
available from CIRPhaseolus Radiatus Seed Starch 1 Final report 09/2015
available from CIRPhenethyl Alcohol 1 up to 1% JACT 9(2):165-83,
1990 confirmed08/06
Phenoxyethanol 1 less than or equalto 0.0002 to 1%
JACT 9(2):259-77,1990
Phenylalanine 1 0.00009 to 0.03% IJT 32(S4):41-64,2013
Phenyl Methyl Pyrazolone 1 up to 1% JACT 11 (4):475-88,1992
Phenyl Trimethicone 1 up to 36% JACT 5(5):353-71, 1986 confirmed
06/04 IJT 25(S2),2006
Phloroglucinol 1 JACT 14(6):468-75,1995
Phosphatidic Acid* 1 safe as used Final report 03/2015available from CIR
Phosphatidylcholine 1 safe as used Final report 03/2015available from CIR
Phosphatidylglycerol* 1 safe as used Final report 03/2015available from CIR
Phosphatidylinositol* 1 safe as used Final report 03/2015available from CIR
Phosphatidylserine* 1 safe as used Final report 03/2015available from CIR
Phospholipids 1 safe as used Final report 03/2015available from CIR
P-hydroxyanisole 1 1 safe for use in nail adhesivesand in artificial nail coatings,as a polymerization inhibitor,that are cured by LED light;
unsafe for use in all othercosmetics due to dermaldepigmentation potential
JACT 4 (5):31-63,1985 confirmed
09/03 IJT 25(S2),2006; Final report12/2014 available
from CIRPhytantriol 1 up to 3% IJT 26(S1):107- 114,
2007Phytosterols 1 Final report 12/2013
available from CIRPhytosteryl butyrate 1 not in current use* Final report 12/2013
available from CIRPhytosteryl canolate 1 Final report 12/2013
available from CIR
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Phytosteryl caprylate/caprate 1 not in current use* Final report 12/2013available from CIR
Phytosteryl hydroxystearate 1 not in current use* Final report 12/2013available from CIR
Phytosteryl isostearate 1 Final report 12/2013available from CIR
Phytosteryl linoleate 1 not in current use* Final report 12/2013available from CIR
Phytosteryl linoleate\linoleate 1 not in current use* Final report 12/2013available from CIR
Phytosteryl Macadamiate 1 Final report 12/2013available from CIR
Phytosteryl Nonanoate 1 not in use at the time* IJT 30(S3):228-269,2011; Final report12/2013 available
from CIRPhytosteryl Oleate 1 Final report 12/2013
available from CIRPhytosteryl Rice Branate 1 Final report 12/2013
available from CIRPhytosteryl Ricinoleate 1 not in current use* Final report 12/2013
available from CIRPhytosteryl sunflowerseedate 1 not in current use* Final report 12/2013
available from CIRPicramic Acid 1 up to 0.6% IJT 28(S3): 205-216,
2009Piper Methysticum Leaf/Root/Stem Extract 1 IJT 28(S2): 175-188,
2009Piper Methysticum Root Extract 1 IJT 28(S2): 175-188,
2009Pistacia Vera Seed Oil 1 0.003 to 1% Final report 03/11
available from CIRPisum Sativum (Pea) Starch 1 Final report 09/2015
available from CIRPlacental Enzymes 1 if used, should not deliver
any metabolic/endocrineactivity, and they must be
free of detectable pathogenicviruses or infectious agents
IJT 21(S1):81-91,2002
Placental Lipids 1 if used, should not deliverany metabolic/endocrineactivity, and they must be
free of detectable pathogenicviruses or infectious agents
IJT 21(S1):81-91,2002
Placental Proteins 1 if used, should not deliverany metabolic/endocrineactivity, and they must be
IJT 21(S1):81-91,2002
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Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
free of detectable pathogenicviruses or infectious agents
Plukenetia Volubilis Seed Oil 1 0.05 to 0.6% Final report 03/11available from CIR
p-Methylaminophenol 1 up to 0.7% Final AmendedReport 12/07
Available from CIRJACT 10(1):53-65,
1991 (original report)p-Methylaminophenol Sulfate (amended) 1 up to 0.7% Final Amended
Report 12/07Available from CIRJACT 10(1):53-65,
1991 (original report)Polianthes Tuberosa Polysaccharide 1 Final report 09/2015
available from CIRPoloxamer 101 1 not in current use* IJT 27 (S2): 93-128,
2008Poloxamer 105 1 up to 3% IJT 27 (S2): 93-128,
2008Poloxamer 105 Benzoate 1 not in current use* IJT 27 (S2): 93-128,
2008Poloxamer 108 1 not in current use* IJT 27 (S2): 93-128,
2008Poloxamer 122 1 not in current use* IJT 27 (S2): 93-128,
2008Poloxamer 123 1 not in current use* IJT 27 (S2): 93-128,
2008Poloxamer 124 1 not in current use* IJT 27 (S2): 93-128,
2008Poloxamer 181 1 up to 6% IJT 27 (S2): 93-128,
2008Poloxamer 182 1 up to 6% IJT 27 (S2): 93-128,
2008Poloxamer 182 Benzoate 1 not in current use* IJT 27 (S2): 93-128,
2008Poloxamer 183 1 not in current use* IJT 27 (S2): 93-128,
2008Poloxamer 184 1 up to 10% IJT 27 (S2): 93-128,
2008Poloxamer 185 1 up to 9% IJT 27 (S2): 93-128,
2008Poloxamer 188 1 up to 2% IJT 27 (S2): 93-128,
2008Poloxamer 212 1 up to 2% IJT 27 (S2): 93-128,
2008
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Poloxamer 215 1 not in current use* IJT 27 (S2): 93-128,2008
Poloxamer 217 1 concentration not reported* IJT 27 (S2): 93-128,2008
Poloxamer 231 1 not in current use* IJT 27 (S2): 93-128,2008
Poloxamer 234 1 up to 10% IJT 27 (S2): 93-128,2008
Poloxamer 235 1 not in current use* IJT 27 (S2): 93-128,2008
Poloxamer 237 1 concentration not reported* IJT 27 (S2): 93-128,2008
Poloxamer 238 1 concentration not reported* IJT 27 (S2): 93-128,2008
Poloxamer 282 1 not in current use* IJT 27 (S2): 93-128,2008
Poloxamer 284 1 not in current use* IJT 27 (S2): 93-128,2008
Poloxamer 288 1 not in current use* IJT 27 (S2): 93-128,2008
Poloxamer 331 1 not in current use* IJT 27 (S2): 93-128,2008
Poloxamer 333 1 1% IJT 27 (S2): 93-128,2008
Poloxamer 334 1 0.3% IJT 27 (S2): 93-128,2008
Poloxamer 335 1 concentration not reported* IJT 27 (S2): 93-128,2008
Poloxamer 338 1 concentration not reported* IJT 27 (S2): 93-128,2008
Poloxamer 401 1 concentration not reported* IJT 27 (S2): 93-128,2008
Poloxamer 402 1 not in current use* IJT 27 (S2): 93-128,2008
Poloxamer 403 1 not in current use* IJT 27 (S2): 93-128,2008
Poloxamer 407 1 up to 20% IJT 27 (S2): 93-128,2008
Polstyrene/hydrogenated polyisopentene copolymer 1 Final report 09/2014available from CIR
Poly(C20-28 olefin)* 1 safe as used Final report 06/2015available from CIR
Poly(C30-45 olefin) 1 safe as used Final report 06/2015available from CIR
Poly(C4-12 olefin)* 1 safe as used Final report 06/2015available from CIR
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Poly(C6-14 olefin)* 1 safe as used Final report 06/2015available from CIR
Polyacrylamide (Amended) 1 safe if the level of acrylamidemonomer in formulationis not greater than 5ppm
IJT 24(S2):21-50,2005 JACT
10(1):193-203, 1991(Original Report)
Polyacrylate-12 1 not in current use* Final report 09/2014available from CIR
Polyacrylate-15 1 Final report 09/2014available from CIR
Polyacrylate-16 1 Final report 09/2014available from CIR
Polyacrylate-18 1 not in current use* Final report 09/2014available from CIR
Polyacrylate-2 1 not in current use* Final report 09/2014available from CIR
Polyacrylate-21 1 Final report 09/2014available from CIR
Polyacrylate-30 1 not in current use* Final report 09/2014available from CIR
Polyacrylate-5 1 Final report 09/2014available from CIR
Polyacrylic Acid 1 safe for use whenformulated to avoid irritation
IJT 21(S3):1-50,2002
Polyamino Sugar Condensate 1 up to 1% JACT 1 (4):25-32,1982 confirmed
02/02 IJT24(S1):80-81, 2005
Polybutene 1 safe as used JACT 1(4):103-18,1982 confirmed
06/02 IJT24(S1):81-82, 2005;Final report 06/2015
available from CIRPolybutylene terephthalate 1 IJT 33(S3):36-47,
2014Polydecene 1 safe as used Final report 06/2015
available from CIRPolydimethylsiloxyethyl dimethicone/bis-vinyldimethiconecrosspolymer
1 not in current use* IJT 33 (S2): 65-115,2014
Polyethylene 1 safe as used IJT 26(S1):115-127,2007; Final report06/2015 available
from CIRPolyethylene isoterephthalate 1 IJT 33(S3):36-47,
2014Polyethylene terephthalate 1 IJT 33(S3):36-47,
2014
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Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Polyglyceryl-20 Octaisononanoate 1 3% Final report 12/11available from CIR
Polyglyceryl-2 Lanolin Alcohol Ether 1 not in current use* Final amended report09/12 available from
CIRPolyglyceryl-3/lauryl polydimethylsiloxyethyl dimethiconecrosspolymer
1 not in current use* IJT 33 (S2): 65-115,2014
Polyisobutene 1 safe as used IJT 27(S4): 83-106,2008; Final report06/2015 available
from CIRPolyisoprene 1 safe as used Final report 06/2015
available from CIRPolymethyl Methacrylate (PMMA) 1 up to 30% IJT 30 (1): 54-65,
2011Polyoxymethylene Melamine (formerly Melamine/Formaldehyde Resin)
1 JACT 14(5):373-85,1995
Polyoxymethylene Urea 1 concentration of freeformaldehyde should be0.2%; unsafe for aerosols
JACT 14(3):204-20,1995 confirmed
12/09Polypentaerythrityl terephthalate 1 not in current use* IJT 33(S3):36-47,
2014Polypentene* 1 safe as used Final report 06/2015
available from CIRPolypropylene 1 safe as used Final report 06/2015
available from CIRPolypropylene Glycols (PPG) 1 50% JACT 13 (6):437-91,
1994 reopened 12/09tentative amended
report 04/10 availablefrom CIR
Polypropylene Terephthalate 1 IJT 33(S3):36-47,2014
Polyquaternium-10 1 up to 5% JACT 7(3): 335-51,1988 confirmed
09/05Polyquaternium-11 1 up to 10% JACT 2(5):161-78,
1983 confirmed11/02 IJT
24(S1):82-83, 2005Polyquaternium-14 1 safe when formulated
to be non- irritatingIJT 31(S3): 296-341
(2012)Polyquaternium-22 1 Final report 09/2013
Available from CIRPolyquaternium-28 1 safe when formulated
to be non- irritatingIJT 31(S3): 296-341
(2012)Polyquaternium-32 1 safe when formulated
to be non- irritatingIJT 31(S3): 296-341
(2012)
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Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Polyquaternium-33 1 safe when formulatedto be non- irritating
IJT 31(S3): 296-341(2012)
Polyquaternium-35 1 safe when formulatedto be non- irritating
IJT 31(S3): 296-341(2012)
Polyquaternium-36 1 safe when formulatedto be non- irritating
IJT 31(S3): 296-341(2012)
Polyquaternium-37 1 safe when formulatedto be non- irritating
IJT 31(S3): 296-341(2012)
Polyquaternium-39 1 Final report 09/2013Available from CIR
Polyquaternium-45 1 safe when formulatedto be non- irritating
IJT 31(S3): 296-341(2012)
Polyquaternium-47 1 safe when formulatedto be non- irritating
IJT 31(S3): 296-341(2012)
Polyquaternium-48 1 safe when formulatedto be non- irritating
IJT 31(S3): 296-341(2012)
Polyquaternium-53 1 safe when formulatedto be non- irritating
IJT 31(S3): 296-341(2012)
Polyquaternium-63 1 safe when formulatedto be non- irritating
IJT 31(S3): 296-341(2012)
Polyquaternium-7 1 up to 0.4% JACT 14(6):476-84, 1995; confirmed
04/2010Polyquaternium-73 1 safe when formulated
to be non- irritatingIJT 31(S3): 296-341
(2012)Polyquaternium-91 1 safe when formulated
to be non- irritatingIJT 31(S3): 296-341
(2012)Polysilicone-13 1 Final report 12/2014
available from CIRPolysilicone-2 1 1 The CIR Expert Panel
concluded that polysilicone-2,polysilicone-4, and
polysilicone-5 are safein cosmetics when usedas surface modifiers (i.e.
encapsulating metal oxides) ,and that the available data orinformation are insufficientto make a determination that
these ingredients are safefor their use independently
or for other functions aslisted in the Dictionary
(e.g., antifoaming agents,hair conditioning agents,and viscosity increasingagents - nonaqueous).
Final 03/2016available from CIR
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Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Polysilicone-4 1 1 The CIR Expert Panelconcluded that polysilicone-2,
polysilicone-4, andpolysilicone-5 are safein cosmetics when usedas surface modifiers (i.e.
encapsulating metal oxides) ,and that the available data orinformation are insufficientto make a determination that
these ingredients are safefor their use independently
or for other functions aslisted in the Dictionary
(e.g., antifoaming agents,hair conditioning agents,and viscosity increasingagents - nonaqueous).
Final 03/2016available from CIR
Polysilicone-5 1 1 The CIR Expert Panelconcluded that polysilicone-2,
polysilicone-4, andpolysilicone-5 are safein cosmetics when usedas surface modifiers (i.e.
encapsulating metal oxides) ,and that the available data orinformation are insufficientto make a determination that
these ingredients are safefor their use independently
or for other functions aslisted in the Dictionary
(e.g., antifoaming agents,hair conditioning agents,and viscosity increasingagents - nonaqueous).
Final 03/2016available from CIR
Polysorbate 20 1 safe as used when formulatedto be non-irritating
JACT 3(5):1-82,1984; Final report06/2015 available
from CIRPolysorbate 21 1 safe as used when formulated
to be non-irritatingJACT 3(5):1-82,
1984; Final report06/2015 available
from CIRPolysorbate 40 1 safe as used when formulated
to be non-irritatingJACT 3(5):1-82,
1984; Final report06/2015 available
from CIR
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Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Polysorbate 60 1 safe as used when formulatedto be non-irritating
JACT 3(5):1-82,1984; Final report06/2015 available
from CIRPolysorbate 61 1 safe as used when formulated
to be non-irritatingJACT 3(5):1-82,
1984; Final report06/2015 available
from CIRPolysorbate 65 1 safe as used when formulated
to be non-irritatingJACT 3(5):1-82,
1984; Final report06/2015 available
from CIRPolysorbate 80 1 safe as used when formulated
to be non-irritatingJACT 3(5):1-82,
1984; Final report06/2015 available
from CIRPolysorbate 81 1 safe as used when formulated
to be non-irritatingJACT 3(5):1-82,
1984; Final report06/2015 available
from CIRPolysorbate 85 1 safe as used when formulated
to be non-irritatingJACT 3(5):1-82,
1984; Final report06/2015 available
from CIRPolystyrene 1 Final report 09/2014
available from CIRPolyvinyl Acetate (Amended) 1 less than 25% of a
55 to 60% emulsionJACT 15(2):166-76,
1996 JACT11(4):465-73, 1992
(Original Report)Polyvinyl Alcohol 1 up to 10% IJT 17(S5):67-94,
1998Potassium Acetate 1 3% IJT 31(S1):112-136,
2012Potassium Acrylates/C10-30 Alkyl Acrylate Crosspolymer 1 safe in the present practices of
use and concentration whennot polymerized in benzene
Final report 11/2011available from CIR
Potassium Alginate 1 Final report 09/2015available from CIR
Potassium Aluminum Polyacrylate 1 safe for use whenformulated to avoid irritation
IJT 21(S3):1-50,2002
Potassium Ascorbyl Tocopheryl Phosphate 1 less than or equal to 0.02% IJT 21(S3):51-116,2002; Final report03/2014 available
from CIRPotassium Aspartate 1 0.003 to 0.008% IJT 32(S4):41-64,
2013
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Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Potassium Babassuate 1 not in use at the time* Final report 03/11available from CIR
Potassium Benzoate 1 0.0002 to 0.0003% Final report 10/11available from CIR
Potassium Bromate 1 10.17% (calculatedas Sodium Bromate)
JACT 13(5):400-14,1994
Potassium Butyl Ester of PVM/MA Copolymer (Amended) 1 not in current use* Amended FinalReport 06/09
Available from CIRJACT 12(3):243-56,
1993 (original report)Potassium C11-15 alkyl phosphate 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 09/2014
available from CIRPotassium C12-13 alkyl phosphate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 09/2014
available from CIRPotassium C12-14 alkyl phosphate 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 09/2014
available from CIRPotassium C9-15 alkyl phosphate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 09/2014
available from CIRPotassium Caproyl Tyrosine 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 12/2013
available from CIRPotassium capryloyl glutamate 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 12/2013
available from CIRPotassium Carrageenan 1 Final report 09/2015
available from CIRPotassium Cellulose Succinate 1 not in use at the time* Amended Safety
Assessment 03/09available from CIR
Potassium Cetyl Phosphate 1 safe for use when formulatedto be non- irritating
Final report 09/2014available from CIR
Potassium Chlorate 1 JACT 14(3):221-30,1995
Potassium citrate 1 0.002 to 0.6% IJT 33 (S2): 16-46,2014
Potassium Cocoate (amended) 1 0.003 to 40% IJT 30(S1):5S-16SPotassium cocoyl glutamate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 12/2013
available from CIRPotassium cocoyl glycinate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 12/2013
available from CIRPotassium Cocoyl Hydrolyzed Collagen (formerlyPotassium-Coco-Hydrolyzed Animal Protein)
1 up to 20% JACT 2(7):75-86,1983 confirmed
11/02 IJT 24(S1):82-85, 2005
Potassium cocoyl rice amino acids 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Potassium Cocoyl Taurate* 1 when formulatedto be non-irritating
Final Report 12/2015available from CIR
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Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Potassium Cornate 1 not in current use* IJT 30 (S1):17-39,2011; Final report
03/11 available fromCIR
Potassium Cumenesulfonate 1 not in current use* IJT 30(S3):270-283,2011
Potassium Dextrin Octenylsuccinate 1 Final report 09/2015available from CIR
Potassium Dodecylbenzenesulfonate (amended) 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 29 (S4) 288-305,2010
Potassium Ethyl Ester of PVM/MA Copolymer 1 not in current use* IJT 30 (S2):128-144,2011
Potassium Gluconate 1 Final report 03/2014available from CIR
Potassium Glycolate 1 IJT 17(S1):1-242,1998
Potassium Glycyrrhetinate 1 up to 1% IJT 26 (S2):79-112,2007
Potassium Glycyrrhizinate 1 not in current use* IJT 26(S2):79-112,2007
Potassium Hyaluronate 1 concentration not reported* IJT 28 (1): 5-67,2009
Potassium Hydrogenated Cocoate (amended) 1 not in current use* IJT 30(S1):5S-16SPotassium Hydrogenated Palmate 1 not in current use* Final report 03/11
available from CIRPotassium Hydroxide 1 safe in hair straighteners and
depilatories under conditionsof recommended use: users
should minimize skin contact;all other uses safe when
formulated to be non-irritating
Final report 12/2015available from CIR
Potassium Lactate 1 IJT 17(S1):1-242,1998
Potassium lauroyl collagen amino acids* 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Potassium lauroyl glutamate* 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Potassium lauroyl oat amino acids* 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Potassium lauroyl pea amino acids* 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Potassium lauroyl silk amino acids* 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Potassium lauroyl wheat amino acids 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Potassium Lauryl Phosphate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2014available from CIR
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Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Potassium Metabisisulfite 1 concentration not reported* IJT 22(S2):63-88,2003
Potassium Methyl Cocoyl Taurate 1 when formulatedto be non-irritating
Final Report 12/2015available from CIR
Potassium Myristate 1 up to 7% IJT 29(S3) :162-186,2010
Potassium Myristoyl Glutamate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Potassium Octoxynol-12 Phosphate 1 up to 0.05% IJT 23(S1):59-111,2004
Potassium Olivate 1 concentration not reported* Final report 03/11available from CIR
Potassium olivoyl/lauroyl wheat amino acids 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Potassium Palmate 1 0.3 to 3% Final report 03/11available from CIR
Potassium Palm Kernelate 1 0.3 to 30% Final report 03/11available from CIR
Potassium PCA 1 safe as used; shouldnot be used in cosmetic
products in which N-nitrosocompounds can be formed
Final report 12/2014available from CIR
Potassium Peanutate 1 not in current use* Final report 03/11available from CIR
potassium PEG-50 hydrogenated castor oil succinate* 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Potassium Persulfate 1 safe as oxidizing agentsin hair colorants and
lighteners designed forbrief, discontinuous usefollowed by thorough
rinsing from hair and skin
IJT 20(S3):7-21,2001
Potassium Polyacrylate 1 safe for use whenformulated to avoid irritation
IJT 21(S3):1-50,2002
Potassium Rapeseedate 1 not in current use* Final report 03/11available from CIR
Potassium Ricinoleate 1 not in current use* IJT 26(S3) 2007Potassium Safflowerate 1 not in current use* Final report 03/11
available from CIRPotassium Salicylate 1 safe when formulated to
avoid irritation and to avoidincreasing sun sensitivity,
or when increased sunsensitivity would be expected,directions for use include thedaily use of sun protection.
IJT 22(3):1-108
Potassium Silicate 1 not reported* safe for use when formulatedto avoid skin irritation
IJT 24(S1):103-117,2005
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Potassium Sorbate 1 up to 1% JACT 7(6):837-80,1988 confirmed
04/06Potassium Soyate 1 not in current use* Final report 03/11
available from CIRPotassium Stearate 1 up to 12% JACT 1(2):143-
77, 1982 confirmed11/01 IJT
22(S1):1-35, 2003Potassium Stearoyl glutamate 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 12/2013
available from CIRPotassium Sulfite 1 concentration not reported* IJT 22(S2):63-88,
2003Potassium Tallate 1 concentration not reported* IJT 28(S3):252-258,
2009Potassium Taurate* 1 when formulated
to be non-irritatingFinal Report 12/2015
available from CIRPotassium Thioglycolate 1 safe for use in hair
straighteners permanentwaves, tonics, dressings,and so forth, wave sets,other noncoloring hair
products, and hair dyes andcolors, at concentrationsup to 15.2%; hairdressersshould avoid skin contact
and minimize consumer skin
IJT 28(S3):68-133,2009
Potassium Toluenesulfonate 1 not in current use* IJT 30(S3):270-283,2011
Potassium Undecylenoyl Alginate 1 Final report 09/2015available from CIR
Potassium Undecylenoyl Carrageenan 1 Final report 09/2015available from CIR
Potassium undecylenoyl glutamate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Potassium Xylenesulfonate 1 not in current use* IJT 30(S3):270-283,2011
Potassium Xylenesulfonate 1 not in current use* IJT 30(S3):270-283,2011
Potato Starch Modified 1 Final report 09/2015available from CIR
PPG-10-Ceteareth-20 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-10 Lanolin Alcohol Ether 1 not in current use* Final amended report09/12 available from
CIRPPG-10 methyl glucose ether 1 Final report 09/2013
Available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
PPG-11 Stearyl Ether 1 2 to 10% IJT 20(S4):53- 59,2001
PPG-12 1 safe when formulatedto be non- irritating
JACT 13(6):437-91,1994; IJT 31(2)245-260, 2012
PPG-12-Buteth-16 1 up to 31% IJT 19(S1):47-67,2000
PPG-12 Butyl Ether 1 safe when formulatedto be non- irritating
IJT 20(S4):39-52,2001
PPG-12 Butyl Ether Dimethicone* 1 Final report 12/2014available from CIR
PPG-12 Dimethicone 1 Final report 12/2014available from CIR
PPG-12-PEG-50 Lanolin 1 0.2 to 8% Final amended report09/12 available from
CIRPPG-12-PEG-65 Lanolin Oil 1 0.002 to 0.04% Final amended report
09/12 available fromCIR
PPG-13 1 safe when formulatedto be non- irritating
IJT 31(2) 245-260,2012
PPG-13-Decyltetradeceth-24 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
PPG-14 Butyl Ether 1 safe when formulatedto be non- irritating
IJT 20(S4):39-52,2001
PPG-14-Deceth-6 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
PPG-15 1 safe when formulatedto be non- irritating
JACT 13(6):437-91,1994; IJT 31(2)245-260, 2012
PPG-15 Butyl Ether 1 safe when formulatedto be non- irritating
IJT 20(S4):39-52,2001
PPG-15 Stearyl Ether 1 2 to 10% IJT 20(S4):53- 59,2001
PPG-16 1 safe when formulatedto be non- irritating
IJT 31(2) 245-260,2012
PPG-16 Butyl Ether 1 safe when formulatedto be non- irritating
IJT 20(S4):39-52,2001
PPG-17 1 safe when formulatedto be non- irritating
JACT 13(6):437-91,1994; IJT 31(2)245-260, 2012
PPG-17 Butyl Ether 1 safe when formulatedto be non- irritating
IJT 20(S4):39-52,2001
PPG-18 Butyl Ether 1 safe when formulatedto be non- irritating
IJT 20(S4):39-52,2001
PPG-1-Ceteth-1 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
PPG-1-Ceteth-10 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-1-Ceteth-20 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-1-Ceteth-5 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-1-Deceth-4 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-1-Deceth-5 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-1-Deceth-6 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-1-Deceth-7 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-1-Isodeceth-4 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-1-Isodeceth-6 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-1-Isodeceth-7 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-1-Isodeceth-9 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-1 Trideceth-13 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-1 Trideceth-6 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-20 1 safe when formulatedto be non- irritating
JACT 13(6):437-91,1994; IJT 31(2)245-260, 2012
PPG-20 Butyl Ether 1 safe when formulatedto be non- irritating
IJT 20(S4):39-52,2001
PPG-20-Decyltetradeceth-10 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
PPG-20 Lanolin Alcohol Ether 1 not in current use* Final amended report09/12 available from
CIRPPG-20 methyl glucose ether 1 Final report 09/2013
Available from CIRPPG-20 methyl glucose ether acetate 1 not in current use* Final report 09/2013
Available from CIRPPG-20 methyl glucose ether distearate 1 Final report 09/2013
Available from CIRPPG-20-PEG-20 Hydrogenated Lanolin 1 not in current use * Final amended report
09/12 available fromCIR
PPG-22 Butyl Ether 1 safe when formulatedto be non- irritating
IJT 20(S4):39-52,2001
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
PPG-23-Steareth-34 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-24 Butyl Ether 1 safe when formulatedto be non- irritating
IJT 20(S4):39-52,2001
PPG-25 Diethylmonium Chloride 1 IJT 18(S3):57- 59,2000
PPG-25 Dimethicone* 1 Final report 12/2014available from CIR
PPG-25-Laureth-25 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
PPG-25 methyl glucose ether 1 not in current use* Final report 09/2013Available from CIR
PPG-26 1 safe when formulatedto be non- irritating
JACT 13(6):437-91,1994; IJT 31(2)245-260, 2012
PPG-26-Buteth-26 1 2.5% IJT 19(S1):47-67,2000
PPG-26 Butyl Ether 1 safe when formulatedto be non- irritating
IJT 20(S4):39-52,2001
PPG-27 Dimethicone* 1 Final report 12/2014available from CIR
PPG-28-Buteth-35 1 22% IJT 19(S1):47-67,2000
PPG-2 Butyl Ether 1 safe when formulatedto be non- irritating
IJT 20(S4):39-52,2001
PPG-2 C12-13 Pareth-8 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
PPG-2 C12-15 Pareth-6 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-2 C9-11 Pareth-11 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-2 C9-11 Pareth-5 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-2 C9-11 Pareth-7 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-2 C9-11 Pareth-8 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-2-Ceteareth-9 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
PPG-2-Ceteth-1 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-2-Ceteth-10 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
PPG-2-Ceteth-20 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-2-Ceteth-5 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
PPG-2-Deceth-10 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-2-Deceth-12 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
PPG-2-Deceth-15 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-2-Deceth-20 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-2-Deceth-3 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
PPG-2-Deceth-30 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-2-Deceth-40 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-2-Deceth-5 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-2-Deceth-50 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-2-Deceth-60 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-2-Deceth-7 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-2-Deceth-8 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-2 Dimethicone 1 Final report 12/2014available from CIR
PPG-2-Isodeceth-10 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-2-Isodeceth-12 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-2-Isodeceth-18 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-2-Isodeceth-25 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-2-Isodeceth-4 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-2-Isodeceth-6 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-2-Isodeceth-8 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-2-Isodeceth-9 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-2 Lanolin Alcohol Ether 1 not in current use* Final amended report09/12 available from
CIRPPG-2-Laureth-12 1 not in current use* safe when formulated
to be non-irritatingFinal report 09/2013Available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
PPG-2-Laureth-5 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-2-Laureth-8 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-2 Methyl Ether 1 up to 2% IJT 28(S2): 162- 174,2009
PPG-2 Methyl Ether Acetate 1 not in current use * IJT 28(S2): 162-174,2009
PPG-2-PEG-11 Hydrogenated Lauryl Alcohol Ether 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-3 1 safe when formulatedto be non- irritating
IJT 31(2) 245-260,2012
PPG-30 1 safe when formulatedto be non- irritating
JACT 13(6):437-91,1994; IJT 31(2)245-260, 2012
PPG-30 Butyl Ether 1 safe when formulatedto be non- irritating
IJT 20(S4):39-52,2001
PPG-30 Lanolin Alcohol Ether 1 not in current use* Final amended report09/12 available from
CIRPPG-30 Steareth-4 1 not in current use* safe when formulated
to be non-irritatingFinal report 09/2013Available from CIR
PPG-33 1 safe when formulatedto be non- irritating
IJT 31(2) 245-260,2012
PPG-33 Butyl Ether 1 safe when formulatedto be non- irritating
IJT 20(S4):39-52,2001
PPG-34 1 safe when formulatedto be non- irritating
JACT 13(6):437-91,1994; IJT 31(2)245-260, 2012
PPG-34-Steareth-3 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
PPG-38 Steareth-6 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-3 C12-14 Sec-Pareth-7 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
PPG-3-Isodeceth-1 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
PPG-3-Isosteareth-9 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
PPG-3-Laureth-10 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
PPG-3-Laureth-12 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
PPG-3-Laureth-8 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
PPG-3-Laureth-9 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
PPG-3 Methyl Ether 1 concentration not reported * IJT 28(S2): 162-174,2009
PPG-3-Myreth-11 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-3-Myreth-3 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-3-PEG-6 Oleyl Ether 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-40 Butyl Ether 1 safe when formulatedto be non- irritating
IJT 20(S4):39-52,2001
PPG-40 Diethylmonium Chloride 1 IJT 18(S3):57-59,1999
PPG-40-PEG-60 Lanolin Oil 1 not in current use* Final amended report09/12 available from
CIRPPG-4 Butyl Ether 1 safe when formulated
to be non- irritatingIJT 20(S4):39-52,
2001PPG-4 C12-14 Sec-Pareth-5 1 safe when formulated
to be non- irritatingFinal report 09/2013Available from CIR
PPG-4 C13-15 Sec-Pareth-15 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
PPG-4-Ceteareth-12 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
PPG-4-Ceteth-1 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
PPG-4-Ceteth-10 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
PPG-4-Ceteth-20 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
PPG-4-Ceteth-5 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
PPG-4-Deceth-4 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
PPG-4-Deceth-6 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
PPG-4-Isodeceth-10 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
PPG-4-Laureth-15 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
PPG-4-Laureth-2 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
PPG-4-Laureth-5 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
PPG-4-Laureth-7 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
PPG-4 Oleth-10 Dimethicone* 1 Final report 12/2014available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
PPG-4-Tricedeth-6 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
PPG-51 1 safe when formulatedto be non- irritating
IJT 31(2) 245-260,2012
PPG-52 1 safe when formulatedto be non- irritating
IJT 31(2) 245-260,2012
PPG-52 Butyl Ether 1 safe when formulatedto be non- irritating
IJT 20(S4):39-52,2001
PPG-53 Butyl Ether 1 safe when formulatedto be non- irritating
IJT 20(S4):39-52,2001
PPG-5 Butyl Ether 1 safe when formulatedto be non- irritating
IJT 20(S4):39-52,2001
PPG-5 C12-14 Sec-Pareth-7 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-5 C12-14 Sec-Pareth-9 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-5 C9-15 Pareth-6 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-5-Ceteth-20 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
PPG-5 Lanolin Alcohol Ether 1 not in current use* Final amended report09/12 available from
CIRPPG-5 Lanolin Wax 1 2.0 to 4.0% IJT 16(S3):307
-316, 1997; Finalamended report 09/12
Available from CIRPPG-5 Lanolin Wax Glyceride 1 not in current use* IJT 16(S3):307-316,
1997; Final amendedreport 09/12
Available from CIRPPG-5-Laureth-5 1 safe when formulated
to be non- irritatingFinal report 09/2013Available from CIR
PPG-69 1 safe when formulatedto be non- irritating
IJT 31(2) 245-260,2012
PPG-6 C12-15 Pareth-12 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-6 C12-18 Pareth-11 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-6 C9-11 Pareth-5 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-6 Deceth-4 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-6 Deceth-9 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-6-Decyltetradeceth-12 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
PPG-6-Decyltetradeceth-20 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
PPG-6-Decyltetradeceth-30 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
PPG-6-Laureth-3 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-6 Trideceth-8 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-7 1 safe when formulatedto be non- irritating
IJT 31(2) 245-260,2012
PPG-8-Ceteth-1 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
PPG-8-Ceteth-10 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
PPG-8-Ceteth-2 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-8-Ceteth-20 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
PPG-8-Ceteth-5 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-8-Deceth-6 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-9 1 safe when formulatedto be non- irritating
JACT 13(6):437-91,1994; IJT 31(2)245-260, 2012
PPG-9-Buteth-12 1 not in current use* IJT 19 (S1):47-67,2000
PPG-9 Butyl Ether 1 safe when formulatedto be non- irritating
IJT 20(S4):39-52,2001
PPG-9 Diethylmonium Chloride 1 IJT 18(S3):57-59,1999
PPG-9-Ethylhexeth-5 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-9-Steareth-3 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG greater than or equal to 3 0 Because PPGs of variouschain lengths are likely to
be added to the InternationalCosmetic Ingredient
Dictionary and Handbookin the future, the CIR
Expert Panel concludedthat any PPGgreater than
or equal to3 would be safefor use in cosmetics when
formulated to be non-ir
IJT 31(2) 245-260,2012
p-Phenylenediamine (amended)** 1 up to 0.04% Final AmendedReport 12/07
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Available from CIRJACT 4(3):203-66,
1985 (original report)p-Phenylenediamine HCl 1 not in current use* Final Amended
Report 12/07Available from CIRJACT 4(3):203-66,
1985 (original report)p-Phenylenediamine Sulfate (amended) 1 not in current use* Final Amended
Report 12/07Available from CIRJACT 4(3):203-66,
1985 (original report)Proline 1 0.00001 to 2% IJT 32(S4):41-64,
2013Propane 1 up to 24% JACT 1(4):127-42,
1982 confirmed06/02 IJT
24(S1):52-55, 2005Propionyl collagen amino acids 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 12/2013
available from CIRPropyl Acetate 1 0.005 to 39% IJT 31(S1):112- 136,
2012Propyl Alcohol 1 0.0001 to 0.5% IJT 31(S1):112 -136,
2012Propyl Benzoate 1 not in current use * IJT 31 (3):342-372
(2012)Propylene Carbonate 1 up to 6% JACT 6(1):23-51,
1987 confirmed09/04 IJT 25(S2),
2006Propylene Glycol 1 50% JACT 13(6):437-91,
1994; IJT 31(2)245-260, 2012
Propylene Glycol Alginate 1 Final report 09/2015available from CIR
Propylene Glycol Behenate* 1 safe when formulatedto be non- irritating
Final report 12/2014available from CIR
Propylene Glycol Capreth-4 1 not in current use* safe for use when formulatedto be non-irritating
Final report 09/2013Available from CIR
Propylene Glycol Caprylate* 1 safe when formulatedto be non- irritating
Final report 12/2014available from CIR
Propylene Glycol Cocoate* 1 safe when formulatedto be non- irritating
Final report 12/2014available from CIR
Propylene Glycol Dicaprate 1 safe when formulatedto be non- irritating
IJT 18 (S2):35-52,1999; Final report12/2014 available
from CIR
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Propylene Glycol Dicaproate 1 safe when formulatedto be non- irritating
Final report 12/2014available from CIR
Propylene Glycol Dicaprylate 1 safe when formulatedto be non- irritating
IJT 18(S2):35-52,1999; Final report12/2014 available
from CIRPropylene Glycol Dicaprylate/dicaprate 1 safe when formulated
to be non-irritatingIJT 18(S2):35-52,1999; Final report12/2014 available
from CIRPropylene Glycol Dicocoate* 1 safe when formulated
to be non- irritatingIJT 18 (S2):35-52,1999; Final report12/2014 available
from CIRPropylene Glycol Diethylhexanoate 1 safe when formulated
to be non- irritatingFinal report 12/2014
available from CIRPropylene Glycol Diisononanoate* 1 safe when formulated
to be non- irritatingIJT 30(Suppl.
3):228-269, 2011;Final report 12/2014
available from CIRPropylene Glycol Diisostearate* 1 safe when formulated
to be non- irritatingIJT 18(S2):35-52,1999; Final report12/2014 available
from CIRPropylene Glycol Dilaurate* 1 safe when formulated
to be non- irritatingIJT 18 (S2):35-52,1999; Final report12/2014 available
from CIRPropylene Glycol Dioleate 1 safe when formulated
to be non- irritatingIJT 18 (S2):35-52,1999; Final report12/2014 available
from CIRPropylene Glycol Dipelargonate 1 safe when formulated
to be non- irritatingIJT 18(S2):35-52,1999; Final report12/2014 available
from CIRPropylene Glycol Distearate* 1 safe when formulated
to be non- irritatingFinal report 12/2014
available from CIRPropylene Glycol Diundecanoate* 1 safe when formulated
to be non- irritatingFinal report 12/2014
available from CIRPropylene Glycol Heptanoate* 1 safe when formulated
to be non- irritatingFinal report 12/2014
available from CIRPropylene Glycol Isodeceth-12 1 not in current use* safe for use when formulated
to be non-irritatingFinal report 09/2013Available from CIR
Propylene Glycol Isodeceth-4 1 not in current use* safe for use when formulatedto be non-irritating
Final report 09/2013Available from CIR
Propylene Glycol Isostearate 1 safe when formulatedto be non- irritating
IJT 18(S2):35-52,1999; Final report
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
12/2014 availablefrom CIR
Propylene Glycol Laurate 1 safe when formulatedto be non- irritating
IJT 18 (S2):35-52,1999; Final report12/2014 available
from CIRPropylene Glycol Laureth-6 1 not in current use* Final report 09/2013
Available from CIRPropylene Glycol Linoleate* 1 safe when formulated
to be non- irritatingFinal report 12/2014
available from CIRPropylene Glycol Linolenate* 1 safe when formulated
to be non- irritatingFinal report 12/2014
available from CIRPropylene Glycol Myristate 1 safe when formulated
to be non- irritatingIJT 18 (S2):35-52,
1999; IJT29(S3) :162-186,2010;
Final report 12/2014available from CIR
Propylene Glycol Oleate 1 safe when formulatedto be non- irritating
IJT 18 (S2):35-52,1999; Final report12/2014 available
from CIRPropylene Glycol Oleate SE 1 up to 50% IJT 18 (S2):35-52,
1999Propylene Glycol Oleate SE (self-emulsifying)* 1 safe when formulated
to be non-irritatingFinal report 12/2014
available from CIRPropylene Glycol Oleth-5 1 not in current use* safe as used when formulated
to be non-irritatingFinal report 09/2013Available from CIR
Propylene Glycol Soyate* 1 safe when formulatedto be non- irritating
Final report 12/2014available from CIR
Propylene Glycol Stearate 1 safe when formulatedto be non- irritating
JACT 2 (5):101-124,1983 confirmed
09/02 IJT24(S1):85-87, 2005;Final report 12/2014
available from CIRPropylene Glycol Stearate SE 1 safe when formulated
to be non- irritatingJACT 2(5):101-124,
1983 confirmed09/02 IJT
24(S1):85-87, 2005;Final report 12/2014
available from CIRPropyl Gallate (Amended) 1 0.10% IJT 26(S3) 2007
JACT 4(3):23-64,1985 (original report)
Propyl Glycolate 1 Glycolic and Lactic Acid,their common salts and their
simple esters, are safe foruse in cosmetic products
IJT 17(S1):1-242,1998
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
at concentrations less thanor equal to10%, at finalformulation pH greater
than or equal to3.5, whenformulated to avoid increasing
sun sensitivity or whendirections for use include
Propylheptyl Caprylate 1 safe as used in cosmeticswhen formulated
to be non-irritating
Final report 03/2013available from CIR
Propylparaben (amended) 1 up to 0.4% if used alone;parabens mixture up to 0.8%
IJT 27(S4): 1-82,2008 JACT
3(5):147-209, 1984(original report)
Prunus Amygdalus Dulcis (Sweet Almond) Oil 1 0.0001 to 77% Final amended report03/11 available
from CIR; JACT2(5):85-99, 1983;
re-review IJT24(S1):98-101, 2005
Prunus Amygdalus Dulcis (Sweet Almond) OilUnsaponifiables
1 not in current use * Final report 03/11available from CIR
Prunus Amygdalus Dulcis (Sweet Almond) Seed Meal (akaAlmond Meal)
1 up to 76% JACT 2(5):85-99,1983 confirmed
11/02 IJT24(S1):98-101, 2005
Prunus Armeniaca (Apricot) Kernel Oil 1 0.00001 to 89% Final report 03/11available from CIR
Prunus Armeniaca (Apricot) Kernel Oil Unsaponifiables 1 not in current use * Final report 03/11available from CIR
Prunus Avium (Sweet Cherry) Seed Oil 1 0.01 to 0.02% Final report 03/11available from CIR
Prunus Domestica Seed Oil 1 up to 0.04% Final report 03/11available from CIR
Prunus Persica (Peach) Gum 1 Final report 09/2015available from CIR
Prunus Persica (Peach) Kernel Oil 1 0.003 to 22% Final report 03/11available from CIR
Pseudoalteromonas exopolysaccharides 1 not in current use* Final report 09/12available from CIR
Pueraria Lobata Starch 1 Final report 09/2015available from CIR
Pullulan 1 0.03 to 17% Final report 09/12available from CIR
Pumpkin Seed Oil PEG-8 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Punica Granatum Seed Oil 1 0.001 to 1% Final report 03/11available from CIR
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Punica Granatum Sterols 1 not in current use* Final report 12/2013available from CIR
PVM/MA Copolymer (amended) 1 up to 13% IJT 30 (S2):128-144,2011
PVP 1 up to 35% IJT 17 (S4):95-130,1998
PVP/Dimethylaminoethyl Methacrylate Copolymer 1 safe for use whenformulated to avoid irritation
IJT 21(S3):1-50,2002
Pyrocatechol (Amended) 1 1 carcinogen; potentialco- carcinogen. NOTE:
for hair dyes, insuff.data to support safety.
IJT16(S1):11-58,1997JACT 5(3):123-65,
1986 (OriginalReport)
Pyrogallol 1 up to 5% JACT 10(1):67-85,1991
Pyromallitic Glycidyl Dimethacrylate 1 safe in nail enhancementproducts when skin contact isavoided; products containing
this ingredient should beaccompanied with directions
to avoid skin contactbecause of the sensitizingpotential of methacrylates
IJT 24(S5):53-100,2005
Pyrophyllite 1 not in current use* IJT 22 (S1):37-102,2003
Pyrus Malus (Apple) Bark Extract* 1 when formulated to be non-irritating and non-sensitizing
Final report 03/2016available from CIR
Pyrus Malus (Apple) Carpel Powder* 1 when formulated to be non-irritating and non-sensitizing
Final report 03/2016available from CIR
Pyrus Malus (Apple) Fiber* 1 when formulated to be non-irritating and non-sensitizing
Final report 03/2016available from CIR
Pyrus Malus (Apple) Flower Extract 1 when formulated to be non-irritating and non-sensitizing
Final report 03/2016available from CIR
Pyrus Malus (Apple) Fruit 1 when formulated to be non-irritating and non-sensitizing
Final report 03/2016available from CIR
Pyrus Malus (Apple) Fruit Extract 1 when formulated to be non-irritating and non-sensitizing
Final report 03/2016available from CIR
Pyrus Malus (Apple) Fruit Water 1 when formulated to be non-irritating and non-sensitizing
Final report 03/2016available from CIR
Pyrus Malus (Apple) Juice 1 when formulated to be non-irritating and non-sensitizing
Final report 03/2016available from CIR
Pyrus Malus (Apple) Leaf Extract* 1 when formulated to be non-irritating and non-sensitizing
Final report 03/2016available from CIR
Pyrus Malus (Apple) Pectin Extract 1 when formulated to be non-irritating and non-sensitizing
Final report 03/2016available from CIR
Pyrus Malus (Apple) Peel Extract* 1 when formulated to be non-irritating and non-sensitizing
Final report 03/2016available from CIR
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Pyrus Malus (Apple) Peel Powder 1 when formulated to be non-irritating and non-sensitizing
Final report 03/2016available from CIR
Pyrus Malus (Apple) Peel Wax* 1 when formulated to be non-irritating and non-sensitizing
Final report 03/2016available from CIR
Pyrus Malus (Apple) Pulp Extract* 1 when formulated to be non-irritating and non-sensitizing
Final report 03/2016available from CIR
Pyrus Malus (Apple) Root Bark Powder* 1 when formulated to be non-irritating and non-sensitizing
Final report 03/2016available from CIR
Pyrus Malus (Apple) Root Extract 1 Final report 03/2016available from CIR
Pyrus Malus (Apple) Seed Extract 1 when formulated to be non-irritating and non-sensitizing
Final report 03/2016available from CIR
Pyrus Malus (Apple) Seed Oil X concentration not reported* Final report 03/11available from CIR
Pyrus Malus (Apple) Stem Extract* 1 Final report 03/2016available from CIR
Quassin 1 IJT 27 (S1):1-43,2008
Quaternium-15 (amended) 1 safe at concentrationsnot to exceed 0.2%
JACT 5(3):61-101,1986 (original
report); Amendedsafety assessment03/09 - Available
from CIR; confirmed03/2011
Quaternium-18 1 up to 2% JACT 1(2):71-83,1982 confirmed
11/01 IJT22(S1):1-35, 2003
Quaternium-18/benzalkonium Bentonite* 1 safe as used when formulatedto be non-irritating
Final report 03/2016available from CIR
Quaternium-18 Bentonite 1 up to 9% JACT 1 (2):71-83,1982 confirmed
11/01 IJT22(S1):1-35, 2003
Quaternium-18 Hectorite (amended) 1 0.05 to 5% in leave-on; concentration notreported for rinse-off
IJT 32(S4):33-40,2013 ; JACT
1(2):71-83 (originalreport), 1982
confirmed 11/01 IJT22(S1):1-35, 2003
Quaternium-22 1 up to 5% JACT 14(6):485-97,1995 confirmed
04/10Quaternium-26 1 should not be used in
products in which N-nitrosocompounds may be formed
IJT 19(S1):69-75,2000
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Quaternium-90 Bentonite 1 safe as used when formulatedto be non-irritating
Final report 03/2016available from CIR
Quaternium-90 Montmorillonite 1 safe as used when formulatedto be non-irritating
Final report 03/2016available from CIR
Quaternium-90 Sepiolite 1 safe as used when formulatedto be non-irritating
Final report 03/2016available from CIR
Rapeseed Acid 1 not in use at the time* Final report 03/11available from CIR
Rapeseed oil PEG-20 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Rapeseed oil PEG-3 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT33(Spump4):13-39,
2014Raspberry seed oil PEG-8 esters 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014Resorcinol 1 up to 5% JACT 5(3):167-203,
1986 confirmed12/06
Retinol 1 up to 5% JACT 6(3):279-320,1987 confirmed
06/05Retinyl Palmitate 1 up to 5% JACT 6(3):279-320,
1987 confirmed06/06
Rhamnose 1 Final report 03/2014available from CIR
Rhizobian gum 1 concentration not reported* Final report 09/12available from CIR
Rhus Succedanea Fruit Wax 0 up to 34% JACT 3 (3):1-41,1984 confirmed
06/03 IJT24(S1):48-52, 2005
Ribes Nigrum (Black Currant) Seed Oil 1 0.000001 to 0.3% Final report 03/11available from CIR
Ribes Rubrum (Currant) Seed Oil 1 not in use at the time* Final report 03/11available from CIR
Ribose 1 Final report 03/2014available from CIR
Rice Amino Acids 1 IJT 33(S4):5-12,2014
Rice bran Acid 1 not in use at the time* Final report 03/11available from CIR
Ricebranamide DEA 1 safe in the present practices ofuse and concentration when
formulated to be non-irritatingand when the levels of freeDEA do not exceed those
considered safe int the CIR
IJT 32(S1):36-58,2013
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
safety assessment of DEAand its salts; should not beused in cosmetic products
Ricinoleamide DEA 1 safe in the present practices ofuse and concentration when
formulated to be non-irritatingand when the levels of freeDEA do not exceed those
considered safe int the CIRsafety assessment of DEAand its salts; should not beused in cosmetic products
IJT 32(S1):36-58,2013
Ricinoleamide MEA 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
IJT 34(S1): 18-34,2015
Ricinoleamidopropyl betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
IJT 31(S1):77-111,2012
Ricinoleamidopropyl dimethylamine 1 not in current use* safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
Final report 06/2014available from CIR
Ricinoleic Acid 1 concentration not reported* IJT 26(S3) 2007Ricinus Communis (Castor) Seed Oil 1 up to 81% IJT 26(S3) 2007Rosa Canina Fruit Oil 1 0.001 to 19% Final report 03/11
available from CIRRosmarinus officinalis (rosemary) extract 1 safe for use in cosmetics
when formulated tobe non-sensitizing.
Final report 06/14available from CIR
Rosmarinus officinalis (rosemary) flower/leaf/stem extract 1 safe for use in cosmeticswhen formulated tobe non-sensitizing.
Final report 06/14available from CIR
Rosmarinus officinalis (rosemary) flower/leaf/stem water 1 not in current use* safe for use in cosmeticswhen formulated tobe non-sensitizing.
Final report 06/14available from CIR
Rosmarinus officinalis (rosemary) flower extract 1 safe for use in cosmeticswhen formulated tobe non-sensitizing.
Final report 06/14available from CIR
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Rosmarinus officinalis (rosemary) leaf 1 safe for use in cosmeticswhen formulated tobe non-sensitizing.
Final report 06/14available from CIR
Rosmarinus officinalis (rosemary) leaf extract 1 safe for use in cosmeticswhen formulated tobe non-sensitizing.
Final report 06/14available from CIR
Rosmarinus officinalis (rosemary) leaf oil 1 safe for use in cosmeticswhen formulated tobe non-sensitizing.
Final report 06/14available from CIR
Rosmarinus officinalis (rosemary) leaf powder 1 safe for use in cosmeticswhen formulated tobe non-sensitizing.
Final report 06/14available from CIR
Rosmarinus officinalis (rosemary) leaf water 1 safe for use in cosmeticswhen formulated tobe non-sensitizing.
Final report 06/14available from CIR
Rosmarinus officinalis (rosemary) water 1 safe for use in cosmeticswhen formulated tobe non-sensitizing.
Final report 06/14available from CIR
Rubus Chamamorus Seed Oil 1 up to 0.1% Final report 03/11available from CIR
Rubus Idaeus (Raspberry) Seed Oil 1 0.1 to 5% Final report 03/11available from CIR
Safflower (Carthamus Tinctorius) Oil 1 up to 84% JACT 4(5):171-97,1985 confirmed
02/04 IJT 25(S2),2006
Safflower Acid 1 Final report 03/11available from CIR
Safflower seed oil PEG-8 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Salicylic Acid 1 safe when formulated toavoid irritation and to avoidincreasing sun sensitivity,
or when increased sunsensitivity would be expected,directions for use include thedaily use of sun protection.
IJT 22(3):1-108
Schinziophyton Rautaneii Kernel Oil 1 concentration not reported* Final report 03/11available from CIR
Schinziophyton Rautanenii Kernel Oil PEG-8 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Sclerocarya Birrea Seed Oil 1 up to 1% Final report 03/11available from CIR
Sclerocarya Birrea Seed Oil PEG-8 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Sclerotium gum 1 0.003 to 2% Final report 09/12available from CIR
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Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
SD Alcohol 30 1 not in current use* IJT 27 (S1):1-43,2008
SD Alcohol 39 1 IJT 27 (S1):1-43,2008
SD Alcohol 39-B 1 concentration not reported* IJT 27 (S1):1-43,2008
SD Alcohol 39-C 1 up to 88% IJT 27 (S1):1-43,2008
SD Alcohol 3-A 1 up to 5% IJT 27 (S1):1-43,2008
SD Alcohol 40 1 IJT 27 (S1):1-43,2008
SD Alcohol 40-B 1 up to 99% IJT 27 (S1):1-43,2008
SD Alcohol 40C 1 not in use at the time* IJT 27 (S1):1-43,2008
SD Alcohol 40-C 1 not in current use* IJT 27 (S1):1-43,2008
Sebacic Acid 1 up to 0.03% in leave-on; up to 1% in rinse- off
IJT 31 (S1):5-76,2012
Sericin 1 Final report 12/2015available from CIR
Serine 1 0.00003 to 2% IJT 32(S4):41-64,2013
Sesame Amino Acids 1 IJT 33(S4):5-12,2014
Sesame Seed oil PEG-8 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Sesamide DEA 1 safe in the present practices ofuse and concentration when
formulated to be non-irritatingand when the levels of freeDEA do not exceed those
considered safe int the CIRsafety assessment of DEAand its salts; should not beused in cosmetic products
IJT 32(S1):36-58,2013
Sesamidopropyl betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
IJT 31(S1):77-111,2012
Sesamidopropyl dimethylamine 1 not in current use* safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
Final report 06/2014available from CIR
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Sesamum Indicum (Sesame) Seed Butter 1 not in use at the time* Final report 03/11available from CIR
Sesamum Indicum (Sesame) Seed Oil (amended) 1 0.0001 to 73% Final amended report03/11 available
from CIR; JACT12(3):261-77, 1993
(original report); IJT30 (1): 40-53, 2011
(amended)Sesamum Indicum (Sesame) Seed Oil Unsaponifiables(amended)
1 0.01 to 0.03% Final amended report03/11 available
from CIR; JACT12(3):261-77, 1993
(original report); IJT30 (1): 40-53, 2011
(amended)Shea butteramide/castoramide DEA 1 safe in the present practices of
use and concentration whenformulated to be non-irritating
and when the levels of freeDEA do not exceed those
considered safe int the CIRsafety assessment of DEAand its salts; should not beused in cosmetic products
IJT 32(S1):36-58,2013
Shea butteramidopropyl betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
IJT 31(S1):77-111,2012
Shellac 1 6% JACT 5(5):309-327,1986 confirmed
12/06; IJT30(S2):73-127, 2011
Silica (amorphous) 1 up to 44% Final Report 09/09available from CIR
Silica dimethyl silylate 1 safe when formulatedand delivered in the
final product not to beirritating or sensitizingto the respiratory tract
IJT 32(S1):5-24,2013
Silica silylate 1 safe when formulatedand delivered in the
final product not to beirritating or sensitizingto the respiratory tract
IJT 32(S1):5-24,2013
Silicone quaternium-16/glycidoxy dimethicone crosspolymer 1 0.003 to 3% IJT 33 (S2): 65-115,2014
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Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Silk 1 Final report 12/2015available from CIR
Silk amino acids 1 IJT 33(S4):5-12,2014
Silk Extract 1 Final report 12/2015available from CIR
Silk Powder 1 Final report 12/2015available from CIR
Silver borosilicate 1 not in current use* IJT 32(S3): 65-72,2013
Silybum Marianum Seed Oil [Thistle] 1 up to 0.5% Final report 03/11available from CIR
Simmondsia Chinensis (Jojoba) Butter (amended) 1 up to 6% Amended FinalReport 09/08 -
available from CIRSimmondsia Chinensis (Jojoba) Seed Oil (amended) 1 up to 100% Amended Final
Report 09/08 -available from CIRJACT 11(1):57-74,
1992 (original report)Simmondsia Chinensis (Jojoba) Wax (amended) 1 up to 2% Amended Final
Report 09/08 -available from CIRJACT 11(1):57-74,
1992 (original report)Sodium/TEA C12-13 Pareth-3 Sulfate 1 not in current use* safe as used when formulated
to be non-irritating. Theingredients should not
be used in cosmeticproducts in which N-nitroso
compounds can be found
IJT 32(S1): 59-81,2013
Sodium/TEA-lauroyl collagen amino acids 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
sodium/TEA-lauroyl keratin amino acids 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Sodium/TEA-Undecylenoyl Alginate 1 Final report 09/2015available from CIR
Sodium/TEA-Undecylenoyl Carrageenan 1 Final report 09/2015available from CIR
sodium/TEA-undecylenoyl collagen amino acids 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Sodium Acetate 1 0.0002 to 0.5% IJT 31(S1):112 -136,2012
Sodium Acrylates/Acrolein Copolymer 1 safe for use whenformulated to avoid irritation
IJT 21(S3):1-50,2002
Sodium Acrylates/C10-30 Alkyl Acrylate Crosspolymer 1 safe in the present practices ofuse and concentration whennot polymerized in benzene
Final report 11/2011available from CIR
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Sodium Acrylates/Vinyl Isodecanoate Crosspolymer 1 safe in the present practices ofuse and concentration whennot polymerized in benzene
Final report 11/2011available from CIR
Sodium Acrylates Copolymer 1 safe for use whenformulated to avoid irritation
IJT 21(S3):1-50,2002
Sodium Acrylates Crosspolymer-2 1 safe in the present practices ofuse and concentration whennot polymerized in benzene
Final report 11/2011available from CIR
Sodium Algin Sulfate 1 Final report 09/2015available from CIR
Sodium Alpha-Olefin Sulfonates (e.g. C12-14 Olefin) 1 safe as used in rinse offproducts; safe up to 2% in
leave ons; the gamma sultoneimpurities should not exceed
10 ppm for unsubstitutedalkane sultones, 1 ppm for
chlorosultones, and 0.1 ppmfor unsaturated sultones
IJT 17(S5):39-66,1998
Sodium Ascorbate 1 up to 0.3% IJT 24(2):51-111,2005
Sodium Ascorbyl Phosphate 1 up to 3% IJT 24 (2):51-111,2005
Sodium Aspartate 1 not in current use* IJT 32(S4):41-64,2013
Sodium Astrocaryum Murumuruate 1 0.002 to 0.005% Final report 03/11available from CIR
Sodium Avocadoate 1 concentration not reported* Final report 03/11available from CIR
Sodium Babassuate 1 8% Final report 03/11available from CIR
Sodium Benzoate 1 0.000001 to 1% Amended finalreport available
from CIR 09/11; IJT20(S3):23-50, 2001
Sodium Benzotriazolyl Butylphenol Sulfonate 1 safe as used Final report 03/2015available on CIR
Sodium Bicarbonate 1 greater than 50% JACT 6 (1):121-138,1987 confirmed
03/05 IJT 25(S2),2006
Sodium Bisulfite 1 up to 0.7% IJT 22(S2):63-88,2003
Sodium Borate 1 5%; but not for use oninfant or injured skin
JACT 2(7):87-125,1983 confirmed
06/03 IJT 25(S2),2006
Sodium Bromate 1 10.17% JACT 13(5):400-14,1994
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Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Sodium Butyl Ester of PVM/MA Copolymer (amended) 1 not in current use* Amended FinalReport 06/09
Available from CIRJACT 12(3):243-56,
1993 (original report)Sodium C10-15 Pareth Sulfate 1 safe when formulated
to be non- irritatingIJT
29(S3) :151-161,2010Sodium C12-13 Pareth Sulfate 1 safe when formulated
to be non- irritatingIJT
29(S3) :151-161,2010Sodium C12-14 Olefin Sulfonate 1 safe as used in rinse off
products; safe up to 2% inleave ons; the gamma sultoneimpurities should not exceed
10 ppm for unsubstitutedalkane sultones, 1 ppm for
chlorosultones, and 0.1 ppmfor unsaturated sultones
IJT 17(S5):39-66,1998
Sodium C12-15 Pareth Sulfate 1 safe when formulatedto be non- irritating
IJT29(S3) :151-161,2010
Sodium C14-16 Olefin Suifonate 1 safe as used in rinse offproducts; safe up to 2% in
leave ons; the gamma sultoneimpurities should not exceed
10 ppm for unsubstitutedalkane sultones, 1 ppm for
chlorosultones, and 0.1 ppmfor unsaturated sultones
IJT 17(S5):39-66,1998
Sodium C14-18 Olefin Sulfonate 1 safe as used in rinse offproducts; safe up to 2% in
leave ons; the gamma sultoneimpurities should not exceed
10 ppm for unsubstitutedalkane sultones, 1 ppm for
chlorosultones, and 0.1 ppmfor unsaturated sultones
IJT 17(S5):39-66,1998
Sodium C16-18 Olefin Sulfonate 1 safe as used in rinse offproducts; safe up to 2% in
leave ons; the gamma sultoneimpurities should not exceed
10 ppm for unsubstitutedalkane sultones, 1 ppm for
chlorosultones, and 0.1 ppmfor unsaturated sultones
IJT 17(S5):39-66,1998
Sodium Caproyl Methyltaurate* 1 when formulatedto be non-irritating
Final Report 12/2015available from CIR
Sodium caproyl prolinate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
sodium capryloyl glutamate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Sodium Carbonate 1 up to 25% JACT 6(1):121-38,1987 confirmed
03/05 IJT 25(S2),2006
Sodium carboxymethyl beta-glucan 1 0.0001 to 0.1% Final report 09/12available from CIR
Sodium carboxymethyl dextran 1 concentration not reported* Final report 09/12available from CIR
Sodium Carboxymethyl Inulin 1 Final report 09/2015available from CIR
Sodium Carboxymethyl Starch 1 Final report 09/2015available from CIR
Sodium Carrageenan 1 Final report 09/2015available from CIR
Sodium Cellulose Sulfate 1 not in use at the time* Amended safetyassesment 03/09
available from CIRSodium Cetearyl Sulfate 1 up to 10% IJT 29(S2): 115-132,
2010 JACT11(1):145-55, 1992
(original report)Sodium Cetyl Sulfate 1 up to 2% IJT 29(S2): 115-132,
2010Sodium citrate 1 0.000005 to 10% IJT 33 (S2): 16-46,
2014Sodium Coceth Sulfate 1 safe in the present practices of
use and concentration whenformulated to be non-irritating
IJT29(S3) :151-161,2010
Sodium Coco/Hydrogenated Tallow Sulfate (amended) 1 not in current use* Amended FinalReport 09/08
Available from CIRSodium Cocoa Butterate 1 not in use at the time* Final report 03/11
available from CIRSodium Cocoamphoacetate 1 0.09 to 18% JACT 9 (2):121-142,
1990; re-review IJT27(Suppl. 1):77-142,
2008Sodium Cocoamphopropionate 1 0.3 to 10% JACT 9 (2):121-142,
1990; re-review IJT27(Suppl. 1):77-142,
2008Sodium Cocoate (amended) 1 1 to 52% IJT 30 (S1):5S-16SSodium Cocomonoglyceride Sulfate (amended) 1 not in current use* IJT 30(S1):5S-16SSodium Coco-Sulfate 1 up to 29% IJT 29(S2): 115-132,
2010
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Sodium cocoyl/hydrogenated tallow glutamate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
sodium cocoyl/palmoyl/sunfloweroyl glutamate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Sodium Cocoyl Alaninate 1 safe for use in cosmeticswhen formulated
to be non- irritating
Final report 12/2013available from CIR
Sodium Cocoyl Amino acids 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Sodium Cocoyl Apple amino acids 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Sodium Cocoyl barley amino acids 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Sodium Cocoyl collagen amino acids 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Sodium cocoyl glutamate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Sodium cocoyl glutaminate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Sodium cocoyl glycinate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Sodium Cocoyl Isethionate 1 safe in the present practices ofuse and concentration when
formulated to be non-irritating
JACT 12(5):459-79,1993 reopened 03/09;
final report 09/2013available from CIR
sodium cocoyl oat amino acids 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
sodium cocoyl proline 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Sodium Cocoyl Sarcosinate 1 safe as used in rinse-offproducts; but 5% in leave-on products. Should not beused in products where N-nitroso compounds may beformed. Insufficient data todetermine safety in products
where these ingredientsare likely to be inhaled.
IJT 20(S1):1-14,2001
Sodium Cocoyl Taurate 1 when formulatedto be non-irritating
Final Report 12/2015available from CIR
Sodium cocoyl threoninate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Sodium cocoyl wheat amino acids 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Sodium Cumenesulfonate 1 up to 3% IJT 30 (S3):270-283,2011
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Sodium Deceth Sulfate 1 safe in the present practices ofuse and concentration when
formulated to be non-irritating
IJT29(S3) :151-161,2010
Sodium Decylbenzenesulfonate (amended) 1 safe for use in cosmetics whenformulated to be non-irritating
JACT 12(3):279-309,1993 (original
report); IJT 29 (S4)288-305, 2010
Sodium Decyl Sulfate 1 concentration not reported* IJT 29(S2): 115-132,2010
Sodium Dehydroacetate 1 up to 0.6% JACT 4 (3):123-159,1985 confirmed
11/03 IJT 25(S2),2006
Sodium dextran sulfate 1 0.005 to 0.5% Final report 09/12available from CIR
Sodium Dextrin Octenylsuccinate 1 Final report 09/2015available from CIR
Sodium Dodecylbenzenesulfonate (amended) 1 safe for use in cosmetics whenformulated to be non-irritating
JACT 12(3):279-309,1993 (original
report); IJT 29 (S4)288-305, 2010
Sodium Erythorbate 1 up to 1% IJT 18(S3):1-26,1999
Sodium Ethyl Ester of PVM/MA Copolymer (amended) 1 not in current use* Amended FinalReport 06/09
Available from CIRJACT 12(3):243-56,
1993 (original report)Sodium Ethylhexyl Sulfate 1 not in current use* IJT 29(S2): 115-132,
2010Sodium Formate 1 Final report 12/2013
available from CIRSodium Fumarate 1 not in current use* Final report 03/09
available from CIRSodium Gluconate 1 Final report 03/2014
available from CIRSodium Glutamate 1 0.01 to 2% IJT 32(S4):41-64,
2013Sodium Glycinate 1 concentration not reported* IJT 32(S4):41-64,
2013Sodium Glycolate 1 Glycolic and Lactic Acid,
their common salts and theirsimple esters, are safe foruse in cosmetic products
at concentrations less thanor equal to10%, at finalformulation pH greater
than or equal to3.5, when
IJT 17(S1):1-242,1998
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
formulated to avoid increasingsun sensitivity or when
directions for use includeSodium Grapeseedate 1 concentration not reported* Final report 12/10
available from CIRSodium Hexametaphosphate 1 safe for use when formulated
to avoid skin irritationIJT 20(S3):75-89,
2001Sodium Hyaluronate 1 up to 2% IJT 28 (1): 5- 67,
2009Sodium Hydrogenated Cocoate (amended) 1 not in current use* IJT 30(S1):5S-16SSodium Hydrogenated Cocoyl Methyl Isethionate 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 09/2013
available from CIRSodium Hydrogenated Palmate 1 not in use at the time* Final report 03/11
available from CIRSodium hydrogenated tallowoyl glutamate 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 12/2013
available from CIRSodium Hydrolyzed Potato Starch Dodecenylsuccinate 1 Final report 09/2015
available from CIRSodium Hydroxide 1 safe in hair straighteners and
depilatories under conditionsof recommended use: users
should minimize skin contact;all other uses safe when
formulated to be non-irritating
Final report 12/2015available from CIR
Sodium Hydroxypropyl Oxidized Starch Succinate 1 Final report 09/2015available from CIR
Sodium Iodate 1 JACT 14(3):231-39,1995
Sodium Isethionate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 09/13available from CIR
Sodium Lactate 1 Glycolic and Lactic Acid,their common salts and their
simple esters, are safe foruse in cosmetic products
at concentrations less thanor equal to10%, at finalformulation pH greater
than or equal to3.5, whenformulated to avoid increasing
sun sensitivity or whendirections for use include
IJT 17(S1):1-242,1998
Sodium Laneth Sulfate 1 safe in the present practices ofuse and concentration when
formulated to be non-irritating
IJT29(S3) :151-161,2010
Sodium Lauraminopropionate 1 IJT 16(S1):1-10,1997
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Sodium Laureth Sulfate 1 safe in the present practices ofuse and concentration when
formulated to be non-irritating
IJT29(S3) :151-161,2010
Sodium Lauriminodipropionate 1 0.05% (rinse-off) IJT 32 (S3):49-55,2013; original report
IJT 16(S1):1-10,1997Sodium lauroyl/myristoyl aspartate 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 12/2013
available from CIRSodium lauroyl aspartate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 12/2013
available from CIRSodium lauroyl collagen amino acids 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 12/2013
available from CIRSodium lauroyl glutamate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 12/2013
available from CIRSodium Lauroyl Isethionate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 09/2013
available from CIRSodium Lauroyl Methyl Isethionate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 09/2013
available from CIRSodium lauroyl millet amino acids 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 12/2013
available from CIRSodium lauroyl oat amino acids 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 12/2013
available from CIRSodium Lauroyl Sarcosinate 1 safe as used in rinse-off
products; but 5% in leave-on products. Should not beused in products where N-nitroso compounds may beformed. Insufficient data todetermine safety in products
where these ingredientsare likely to be inhaled.
IJT 20(S1):1-14,2001
Sodium lauroyl silk amino acids 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Sodium Lauroyl Taurate 1 when formulatedto be non-irritating
Final Report 12/2015available from CIR
Sodium lauroyl wheat amino acids 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Sodium Lauryl Phosphate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2014available from CIR
Sodium Lauryl Sulfate 1 safe for use in rinse-off products; but 1%for leave-on products
JACT 2(7):127-181,1983 confirmed
06/02 IJT24(S1):89-98, 2005
Sodium Lauryl Sulfoacetate 1 up to 21% JACT 6 (3):261-277,1987 confirmed
12/04 IJT 25(S2),2006
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Sodium Macadamiaseedate 1 not in use at the time* Final report 03/11available from CIR
Sodium Magnesium Silicate 1 up to 5% IJT 22 (S1):37-102,2003
Sodium Malate 1 safe for use as pH adjusters;insufficient data to support
safety for other uses
IJT 20(S1):47-55,2001
Sodium Mangoseedate 1 concentration not reported* Final report 03/11available from CIR
Sodium Metabisulfite 1 up to 14% IJT 22(S2):63 -88,2003
Sodium Metaphosphate 1 safe for use when formulatedto avoid skin irritation
IJT 20(S3):75-89,2001
Sodium Metasilicate 1 up to 14% safe for use when formulatedto avoid skin irritation
IJT 24(S1):103-117,2005
Sodium methyacrylate/styrene copolymer 1 not in current use* Final report 09/2014available from CIR
Sodium Methyl Cocoyl Taurate 1 when formulatedto be non-irritating
Final Report 12/2015available from CIR
Sodium Methyl Isethionate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2013available from CIR
Sodium Methyl Lauroyl Taurate 1 when formulatedto be non-irritating
Final Report 12/2015available from CIR
Sodium Methyl Myristoyl Taurate 1 when formulatedto be non-irritating
Final Report 12/2015available from CIR
Sodium Methyl Oleoyl Taurate 1 when formulatedto be non-irritating
Final Report 12/2015available from CIR
Sodium Methyl Palmitoyl Taurate 1 when formulatedto be non-irritating
Final Report 12/2015available from CIR
Sodium Methyl Stearoyl Taurate 1 when formulatedto be non-irritating
Final Report 12/2015available from CIR
Sodium Methyltaurate 1 when formulatedto be non-irritating
Final Report 12/2015available from CIR
Sodium Methyltaurate Isopalmitamide* 1 when formulatedto be non-irritating
Final Report 12/2015available from CIR
Sodium Methyltaurine Cocoyl Methyltaurate 1 when formulatedto be non-irritating
Final Report 12/2015available from CIR
Sodium-m-Nitrobenzenesulfonate 1 JACT 15(4):337-47,1996
Sodium Myreth Sulfate 1 safe in the present practices ofuse and concentration when
formulated to be non-irritating
IJT29(S3) :151-161,2010
Sodium Myristate 1 up to 6% IJT 29(S3):162-186,2010
Sodium myristoyl glutamate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Sodium Myristoyl Isethionate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2013available from CIR
Sodium Myristoyl Sarcosinate 1 safe as used in rinse-offproducts; but 5% in leave-on products. Should not beused in products where N-nitroso compounds may beformed. Insufficient data todetermine safety in products
where these ingredientsare likely to be inhaled.
IJT 20(S1):1-14,2001
Sodium Myristyl Sulfate 1 concentration not reported* IJT 29(S2): 115-132,2010
Sodium Naphthalenesulfonate (amended) 1 below 2% safe as used in cosmeticformulations intended tobe applied to skin; but
insufficient data to support thesafety in cosmetic productswhich may contact mucousmembranes or be ingested.
IJT 22(S2):37-44,2003
Sodium N-isostearoyl Methyltaurate* 1 when formulatedto be non-irritating
Final Report 12/2015available from CIR
Sodium Octoxynol-2 Ethane Sulfonate 1 not in current use* safe as used in rinse-off products; safe at 5%
in leave-on products
IJT 23(S1):59-111,2004
Sodium Octoxynol-2 Sulfate 1 not in current use* safe as used in rinse-off products; safe at 5%
in leave-on products
IJT 23(S1):59-111,2004
Sodium Octoxynol-6 Sulfate 1 not in current use* safe as used in rinse-off products; safe at 5%
in leave-on products
IJT 23(S1):59-111,2004
Sodium Octoxynol-9 Sulfate 1 not in current use* IJT 23(S1):59-111,2004
Sodium Oleoyl Isethionate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2013available from CIR
Sodium Oleth Sulfate 1 safe in the present practices ofuse and concentration when
formulated to be non-irritating
IJT29(S3) :151-161,2010
Sodium Oleyl Methyl Isethionate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2013available from CIR
Sodium Oleyl Sulfate 1 not in current use* IJT 29(S2): 115-132,2010
Sodium Olivate 1 4 to 18% Final report 03/11available from CIR
Sodium olivoyl glutamate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Sodium Oxidized Starch Acetate/Succinate 1 Final report 09/2015available from CIR
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Sodium Palmate 1 3 to 68% Final report 03/11available from CIR
Sodium palmitoyl proline 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Sodium Palm Kernelate 1 12 to 44% Final report 03/11available from CIR
Sodium Palm Kerneloyl Isethionate 1 not in current use* Final report 09/2013available from CIR
Sodium palmoyl glutamate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Sodium PCA 1 should not be used in cosmeticproducts in which N-nitrosocompounds can be formed
IJT 18(S2):25-34,1999; Final report12/2014 available
from CIRSodium p-Chloro-m-Cresol (amended) 1 up to 0.5% IJT 25(S1):29-127,
2006Sodium Peanutate 1 not in current use* Final report 03/11
available from CIRSodium PEG-50 hydrogenated castor oil succinate 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014Sodium Persulfate 1 safe as oxidizing agents
in hair colorants andlighteners designed forbrief, discontinuous usefollowed by thorough
rinsing from hair and skin
IJT 20(S3):7-21,2001
Sodium Picramate (amended) 1 concentration not reported* IJT 28(S3): 205-216,2009 JACT
11(4):447-64, 1992(original report)
Sodium Polyacrylate 1 safe for use whenformulated to avoid irritation
IJT 21(S3):1-50,2002
Sodium Polynaphthalenesulfonate (amended) 1 safe as used in cosmeticformulations intended to be
applied to skin (0.3% is max.use concentration reportedin skin care products); but
insufficient data to support thesafety in cosmetic productswhich may contact mucousmembranes or be ingested.
IJT 22(S2):37-44,2003
Sodium Potassium Aluminum Silicate 1 up to 4% Final Report 09/09available from CIR
Sodium rapeseedate 1 not in current use* Final report 03/11available from CIR
Sodium Ricinoleate 1 concentration not reported* IJT 26(S3): 31-77,2007
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Sodium Safflowerate 1 not in current use* Final report 03/11available from CIR
Sodium Salicylate 1 safe when formulated toavoid irritation and to avoidincreasing sun sensitivity,
or when increased sunsensitivity would be expected,directions for use include thedaily use of sun protection.
IJT 22(3):1-108,2003
Sodium Sesameseedate (amended) 1 not in current use* Final amended report03/11 available
from CIR; JACT12(3):261-77, 1993
(original report); IJT30 (1): 40-53, 2011
(amended)Sodium Sesquicarbonate 1 greater than 50% JACT 6(1):121-38,
1987 confirmed03/05 IJT 25(S2),
2006Sodium Silicate 1 up to 35% safe for use when formulated
to avoid skin irritationIJT 24(S1):103-117,
2005Sodium Soyate 1 not in current use* Final report 03/11
available from CIRSodium Starch Octenylsuccinate 1 Final report 09/2015
available from CIRSodium Stearate 1 up to 25% JACT 1(2):143-77,
1982 confirmed11/01 IJT
22(S1):1-35, 2003Sodium stearoyl glutamate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 12/2013
available from CIRSodium Stearoyl Methyl Isethionate 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 09/2013
available from CIRSodium Stearyl Fumarate. 1 not in current use* Final report 03/09
available from CIRSodium Stearyl Sulfate 1 not reported* IJT 29 (S2): 115-132,
2010Sodium styrene/acrylates/ethylhexyl acrylate/lauryl acrylatecopolymer
1 not in current use* Final report 09/2014available from CIR
Sodium Styrene/Acrylates Copolymer 1 IJT 21(S3):1-50,2002; Final report09/2014 available
from CIRSodium Succinate 1 concentration not reported* IJT 31 (S1):5-76,
2012Sodium Sulfate 1 up to 1% in leave-
on formulationsIJT 19(S1):77-87,
2000
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Sodium Sulfite 1 up to 3% IJT 22(S2):63-88,2003
Sodium Sweet Almondate 1 up to 15% Final report 03/11available from CIR
Sodium Tallate 1 concentration not reported* IJT 28(S3):252-258,2009
Sodium Tallow Sulfate 1 not in current use* IJT 29(S2): 115-132,2010
Sodium Taurate* 1 when formulatedto be non-irritating
Final Report 12/2015available from CIR
Sodium Taurine Cocoyl Methyltaurate* 1 when formulatedto be non-irritating
Final Report 12/2015available from CIR
Sodium Theobroma Grandiflorum Seedate 1 not in current use* Final report 03/11available from CIR
Sodium Thioglycolate 1 safe for use in hairstraighteners permanentwaves, tonics, dressings,and so forth, wave sets,other noncoloring hair
products, and hair dyes andcolors, at concentrationsup to 15.2%; hairdressersshould avoid skin contact
and minimize consumer skin
IJT 28(S3):68-133,2009
Sodium Tocopheryl Phosphate 1 Final report 03/2014available from CIR
Sodium Toluenesulfonate 1 not in current use* IJT 30(S3):270-283,2011
Sodium Trideceth Sulfate 1 up to 19% IJT29(S3) :151-161,2010
Sodium Tridecylbenzenesulfonate 1 safe as cosmetic ingredientsin the present practices of
use and concentration whenformulated to be non-irritating
IJT 29(S4):288-305,2010
Sodium Tridecyl Sulfate 1 not in current use* IJT 29(S2): 115-132,2010
Sodium Trimetaphosphate 1 safe for use when formulatedto avoid skin irritation
IJT 20(S3):75-89,2001
Sodium undecylenoyl glutamate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Sodium Xylenesulfonate 1 up to 15% IJT 30 (S3):270-283,2011
Solanum Lycopersicum (Tomato) Fruit Oil 1 0.01 to 1% Final report 03/11available from CIR
Solanum Lycopersicum (Tomato) Seed Oil 1 concentration not reported* Final report 03/11available from CIR
Solanum Tuberosum (Potato) Starch 1 Final report 09/2015available from CIR
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Sorbeth-12 hexacocoate* 1 safe as used when formulatedto be non-irritating
Final report 06/2015available from CIR
Sorbeth-150 hexastearate* 1 safe as used when formulatedto be non-irritating
Final report 06/2015available from CIR
Sorbeth-160 tristearate* 1 safe as used when formulatedto be non-irritating
Final report 06/2015available from CIR
Sorbeth-2/oleate/dimer dilinoleate crosspolymer* 1 safe as used when formulatedto be non-irritating
Final report 06/2015available from CIR
Sorbeth-20 beeswax 1 safe as used when formulatedto be non-irritating
Final report 06/2015available from CIR
Sorbeth-20 pentaisostearate* 1 safe as used when formulatedto be non-irritating
Final report 06/2015available from CIR
Sorbeth-20 tetraisostearate* 1 safe as used when formulatedto be non-irritating
Final report 06/2015available from CIR
Sorbeth-2 beeswax* 1 safe as used when formulatedto be non-irritating
Final report 06/2015available from CIR
Sorbeth-2 cocoate* 1 safe as used when formulatedto be non-irritating
Final report 06/2015available from CIR
Sorbeth-2 hexacaprylate/caprate* 1 safe as used when formulatedto be non-irritating
Final report 06/2015available from CIR
Sorbeth-2 hexaisostearate* 1 safe as used when formulatedto be non-irritating
Final report 06/2015available from CIR
Sorbeth-2 hexalaurate* 1 safe as used when formulatedto be non-irritating
Final report 06/2015available from CIR
Sorbeth-2 hexaoleate* 1 safe as used when formulatedto be non-irritating
Final report 06/2015available from CIR
Sorbeth-30 pentaisostearate* 1 safe as used when formulatedto be non-irritating
Final report 06/2015available from CIR
Sorbeth-30 tetraisostearate 1 safe as used when formulatedto be non-irritating
Final report 06/2015available from CIR
Sorbeth-30 tetraoleate 1 safe as used when formulatedto be non-irritating
Final report 06/2015available from CIR
Sorbeth-30 tetraoleate laurate (PEG-30 sorbitol tetraoleatelaurate)*
1 safe as used when formulatedto be non-irritating
Final report 06/2015available from CIR
Sorbeth-3 isostearate* 1 safe as used when formulatedto be non-irritating
Final report 06/2015available from CIR
Sorbeth-3 tristearate* 1 safe as used when formulatedto be non-irritating
Final report 06/2015available from CIR
Sorbeth-40 Hexaoleate 1 concentration not reported* IJT 19(S2):43-89,2000
Sorbeth-40 Hexaoleate 1 concentration not reported* IJT 19(S2):43-89,2000
Sorbeth-40 hexaoleate (PEG-40 sorbitol hexaoleate)* 1 safe as used when formulatedto be non-irritating
Final report 06/2015available from CIR
Sorbeth-40 pentaisostearate* 1 safe as used when formulatedto be non-irritating
Final report 06/2015available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Sorbeth-40 pentaoleate* 1 safe as used when formulatedto be non-irritating
Final report 06/2015available from CIR
Sorbeth-40 tetraisostearate* 1 safe as used when formulatedto be non-irritating
Final report 06/2015available from CIR
Sorbeth-40 tetraoleate 1 safe as used when formulatedto be non-irritating
Final report 06/2015available from CIR
Sorbeth-450 tristearate* 1 safe as used when formulatedto be non-irritating
Final report 06/2015available from CIR
Sorbeth-4 tetraoleate 1 safe as used when formulatedto be non-irritating
Final report 06/2015available from CIR
Sorbeth-50 hexaoleate (PEG-50 sorbitol hexaoleate)* 1 safe as used when formulatedto be non-irritating
Final report 06/2015available from CIR
Sorbeth-50 pentaisostearate* 1 safe as used when formulatedto be non-irritating
Final report 06/2015available from CIR
Sorbeth-50 tetraisostearate* 1 safe as used when formulatedto be non-irritating
Final report 06/2015available from CIR
Sorbeth-60 tetraoleate 1 safe as used when formulatedto be non-irritating
Final report 06/2015available from CIR
Sorbeth-60 tetrastearate (PEG-60 sorbitol tetrastearate)* 1 safe as used when formulatedto be non-irritating
Final report 06/2015available from CIR
Sorbeth-6 beeswax 1 safe as used when formulatedto be non-irritating
Final report 06/2015available from CIR
Sorbeth-6 hexastearate* 1 safe as used when formulatedto be non-irritating
Final report 06/2015available from CIR
Sorbeth-6 laurate* 1 safe as used when formulatedto be non-irritating
Final report 06/2015available from CIR
Sorbeth-6 tetraoleate 1 safe as used when formulatedto be non-irritating
Final report 06/2015available from CIR
Sorbeth-8 beeswax* 1 safe as used when formulatedto be non-irritating
Final report 06/2015available from CIR
Sorbeth Tetraoleate Laurate 1 concentration not reported* IJT 19(S2):43-89,2000
Sorbeth Tetrastearate 1 concentration not reported* IJT 19(S2):43-89,2000
Sorbic Acid 1 up to 5% JACT 7(6):837-80,1988 confirmed
04/06Sorbitan Caprylate 1 IJT 21(S1):93-112,
2002; Final report12/2014 available
from CIRSorbitan Cocoate* 1 IJT 21 (S1):93-112,
2002; Final report12/2014 available
from CIRSorbitan Diisostearate* 1 IJT 21(S1):93-112,
2002; Final report
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
12/2014 availablefrom CIR
Sorbitan Dioleate* 1 IJT 21 (S1):93-112,2002; Final report12/2014 available
from CIRSorbitan Distearate* 1 IJT 21(S1):93-112,
2002; Final report12/2014 available
from CIRSorbitan Isostearate 1 IJT 21(S1):93-112,
2002; Final report12/2014 available
from CIRSorbitan Laurate 1 JACT 4(3):65-121,
1985; Final report12/2014 available
from CIRSorbitan Oleate 1 JACT 4(3):65-121,
1985; Final report12/2014 available
from CIRSorbitan Olivate 1 IJT 21(S1):93- 112,
2002; Final report12/2014 available
from CIRSorbitan Palmate 1 Final report 12/2014
available from CIRSorbitan Palmitate 1 JACT 4(3):65-121,
1985; Final report12/2014 available
from CIRSorbitan Sesquicaprylate* 1 Final report 12/2014
available from CIRSorbitan Sesquiisostearate 1 IJT 21 (S1):93-112,
2003; Final report12/2014 available
from CIRSorbitan Sesquioleate 1 JACT 4(3):65 -121,
1985; Final report12/2014 available
from CIRSorbitan Sesquistearate* 1 IJT 21(S1):93-112,
2002; Final report12/2014 available
from CIRSorbitan Stearate 1 JACT 4(3):65-121,
1985; Final report
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
12/2014 availablefrom CIR
Sorbitan Triisostearate 1 IJT 21(S1):93-112,2002; Final report12/2014 available
from CIRSorbitan Trioleate 1 JACT 4(3):65-121,
1985; Final report12/2014 available
from CIRSorbitan Tristearate 1 JACT 4(3):65-121,
1985; Final report12/2014 available
from CIRSorbitan Undecylenate* 1 Final report 12/2014
available from CIRSoy Acid 1 not in current use* Final report 03/11
available from CIRSoyamide DEA 1 safe in the present practices of
use and concentration whenformulated to be non-irritating
and when the levels of freeDEA do not exceed those
considered safe int the CIRsafety assessment of DEAand its salts; should not beused in cosmetic products
IJT 32(S1):36-58,2013
Soyamidopropyl betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
IJT 31(S1):77-111,2012
Soyamidopropyl dimethylamine 1 not in current use* safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
Final report 06/2014available from CIR
Soy Amino Acids 1 IJT 33(S4):5-12,2014
Soybean oil PEG-20 ester 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Soybean Oil PEG-36 Esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Soybean Oil PEG-8 Esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Soybean Oil Propylene Glycol Esters* 1 safe when formulatedto be non-irritating
Final report 12/2014available from CIR
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Soy sterol acetate 1 Final report 12/2013available from CIR
Soytrimonium chloride 1 safe when formulatedto be non- irritating
IJT 31(S3): 296-341(2012)
Spirulina Amino Acids 1 not in current use* IJT 33(S4):5-12,2014
Squalane 1 up to 31% JACT 1(2):37-56,1982 confirmed
09/01 IJT22(S1):1-35, 2003
Squalene 1 up to 10% JACT 1(2):37-56,1982 confirmed
09/01 IJT22(S1):1-35, 2003
Starch Acetate 1 Final report 09/2015available from CIR
Starch Acetate/Adipate 1 Final report 09/2015available from CIR
Starch Diethylaminoethyl Ether 1 Final report 09/2015available from CIR
Starch Hydroxypropyltrimonium Chloride 1 Final report 09/2015available from CIR
Starch Laurate 1 Final report 09/2015available from CIR
Starch Tallowate 1 Final report 09/2015available from CIR
Steapyrium Chloride 1 0.1 to 3% JACT 10(1):87-97, 1991; IJT
30(S2):73-127, 2011Stearalkonium Bentonite 1 safe as used when formulated
to be non-irritatingFinal report 03/2016
available from CIRStearalkonium Chloride 1 up to 7% JACT 1(2):57 -69,
1982 confirmed11/01 IJT
22(S1):1-35, 2003Stearalkonium Hectorite (amended) 1 0.006 to 6% IJT 32(S4):33-40,
2013; IJT19(S2):91-98, 2000
(original report)Stearamide DEA 1 safe in the present practices of
use and concentration whenformulated to be non-irritating
and when the levels of freeDEA do not exceed those
considered safe int the CIRsafety assessment of DEAand its salts; should not beused in cosmetic products
IJT 32(S1):36-58,2013
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Stearamide DIBA-Stearate 1 IJT 20(S3):91-97,2001
Stearamide MEA 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
IJT 34(S1): 18-34,2015
Stearamidopropyl Betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
IJT 31(S1):77-111,2012
Stearamidopropyl Dimethicone 1 not in current use* IJT 22(S2):11-35,2003
Stearamidopropyl Dimethylamine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
Final report 06/2014available from CIR
Stearamine 1 JACT 14(3):196-203,1995
Stearamine Oxide 1 safe for use in rinse-off products; but 5%for leave-on products
JACT 13(5):231-45,1994 confirmed
09/09; IJT30(S2):73-127, 2011
Steareth-1 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Steareth-10 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Steareth-100 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Steareth-10 Allyl Ether/Acrylates Copolymer 1 safe for use whenformulated to avoid irritation
IJT 21(S3):1-50,2002
Steareth-11 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Steareth-13 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Steareth-14 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Steareth-15 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Steareth-16 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Steareth-2 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Steareth-20 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Steareth-200 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Steareth-25 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Steareth-27 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Steareth-3 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Steareth-30 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Steareth-4 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Steareth-40 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Steareth-5 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Steareth-50 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Steareth-60 Cetyl Ether 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
Steareth-7 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Steareth-8 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Steareth-80 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Stearic Acid 1 greater than 50% JACT 6(3):321-401, 1987 confirmed
06/05 IJT 25(S2),2006
Stearic Hydrazide 1 JACT 10(1):99-101,1991
Stearoxy Dimethicone 1 IJT 22(S2):11- 35,2003; Final report12/2014 available
from CIRStearoxymethicone/dimethicone Copolymer 1 Final report 12/2014
available from CIRStearoxypropyltrimonium chloride 1 safe when formulated
to be non- irritatingIJT 31(S3): 296-341
(2012)Stearoyl ethyltrimonium methosulfate 1 safe when formulated
to be non-irritatingIJT 31(S3): 296-341
(2012)Stearoyl glutamic acid 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 12/2013
available from CIRStearoyl Inulin 1 Final report 09/2015
available from CIRStearoyl leucine 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 12/2013
available from CIRStearoyl Sarcosine 1 safe as used in rinse-off
products; but 5% in leave-on products. Should not beused in products where N-nitroso compounds may beformed. Insufficient data todetermine safety in products
where these ingredientsare likely to be inhaled.
IJT 20(S1):1-14,2001
Steartrimonium Bromide 1 safe when formulatedto be non- irritating
IJT 31(S3): 296-341(2012)
Steartrimonium Chloride 1 up to o.25% for leave-on products (no rinse-
off uses reported)
IJT 16(S3):195-220,1997; IJT 31(S3):
296-341 (2012)Steartrimonium methosulfate 1 safe when formulated
to be non- irritatingIJT 31(S3): 296-341
(2012)Stearyl/Lauryl Methacrylate Crosspolymer 1 safe in the present practices of
use and concentration whennot polymerized in benzene
Final report 11/2011available from CIR
Stearyl Acetate 1 0.2 to 0.5% IJT 31(S1):112- 136,2012
Stearyl Alcohol 1 up to 25% JACT 4(5):1-29,1985 confirmed
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
03/04 IJT 25(S2),2006
Stearyl Beeswax 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Stearyl Behenate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2): 141-146,2012; final report03/2013 available
from CIRStearyl Benzoate 1 2% IJT 31(3):342-372
(2012)Stearyl betaine 1 concentration not reported* safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2014
available from CIRStearyl Caprylate 1 0.1 to 1% safe for use in cosmetics when
formulated to be non-irritatingIJT 31(S2): 141-146,
2012; final report03/2013 available
from CIRStearyl citrate 1 0.007 to 12% IJT 33 (S2): 16 -46,
2014Stearyl Dimethicone 1 up to 6% IJT 22(S2):11- 35,
2003Stearyl Erucate 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIRStearyl Ethylhexanoate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIRStearyl Glycol 1 not in use at the time* IJT 31 (S2): 147-168,
2012Stearyl Glycyrrhetinate 1 up to 1% IJT 26 (S2):79-112,
2007Stearyl Heptanoate (amended) 1 0.07 to 8% JACT 14(6):497-510,
1995; IJT 31(S2):141-146, 2012;
final report 03/2013available from CIR
Stearyl Linoleate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Stearyl Methicone 1 up to 6% IJT 22(S2):11-35,2003
Stearyl Olivate 1 concentration not reported* safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2): 141-146,2012; final report03/2013 available
from CIRStearyl Palmitate 1 up to 3% safe for use in cosmetics when
formulated to be non-irritatingIJT 31(S2): 141-146,
2012; final report03/2013 available
from CIRStearyl Phosphate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 09/2014
available from CIR
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Stearyl Stearate 1 0.02 to 4% safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2): 141-146,2012; final report03/2013 available
from CIRSterculia Urens Gum 1 Final report 09/2015
available from CIRStyrene/Acrylates/Ammonium Methacrylate Copolymer 1 safe for use when
formulated to avoid irritationIJT 21(S3):1-50,
2002Styrene/acrylates/dimethicone acrylate crosspolymer 1 not in use at the time* IJT 33 (S2): 65-115,
2014Styrene/acrylates/ethylhexyl acrylate/lauryl acrylatecopolymer
1 not in current use* Final report 09/2014available from CIR
Styrene/Acrylates Copolymer 1 IJT 21(S3):1-50,2002; Final report09/2014 available
from CIRStyrene/butadiene copolymer 1 Final report 09/2014
available from CIRStyrene/isoprene copolymer 1 not in current use* Final report 09/2014
available from CIRStyrene/methylstyrene copolymer 1 not in current use* Final report 09/2014
available from CIRStyrene/stearyl methacrylate crosspolymer 1 not in current use* Final report 09/2014
available from CIRStyrene/va copolymer 1 not in current use* Final report 09/2014
available from CIRStyrene/vp copolymer 1 Final report 09/2014
available from CIRSuccinic Acid 1 up to 0.2% in leave-on;
up to 26% in rinse- offIJT 31 (S1):5-76,
2012Sucralose 1 Final report 03/2014
available from CIRSucrose 1 Final report 03/2014
available from CIRSunfloweramide MEA 1 safe in the present practices
of use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
IJT 34(S1): 18-34,2015
Sunflower Seed Acid 1 not in use at the time* Final report 03/11available from CIR
Sunflowerseedamidopropyl dimethylamine 1 not in current use* safe for use in cosmeticswhen formulated to be non-
sensitizing, which may
Final report 06/2014available from CIR
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
be based on a quantitativerisk assessment (QRA)
Sunflower seed oil PEG-32 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Sunflower seed oil PEG-8 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Sweet Almond Amino Acids 1 not in current use* IJT 33(S4):5-12,2014
Sweet almond oil PEG-8 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Synthetic Beeswax 1 up to 18% JACT 3(3):43-99,1984 confirmed
06/03 IJT24(S1):67-74, 2005
Synthetic Fluorphlogopite 1 0.00002-67% Final report 06/12available from CIR
Synthetic Jojoba Oil (amended) 1 up to 0.1% Amended FinalReport 09/08 -
available from CIRSynthetic Wax 1 up to 29% JACT 3(3):43-99,
1984 confirmed06/03 IJT
24(S1):67-74, 2005Talc 1 IJT 34(S1):66-129,
2015Tallamide DEA 1 safe in the present practices of
use and concentration whenformulated to be non-irritating
and when the levels of freeDEA do not exceed those
considered safe int the CIRsafety assessment of DEAand its salts; should not beused in cosmetic products
IJT 32(S1):36-58,2013
Tallamidopropyl Dimethylamine 1 not in current use* safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
Final report 06/2014available from CIR
Tall Oil Acid (amended) 1 up to 8% IJT 28 (S3):252-258,2009 JACT
8(4):769-776, 1989(original report)
Tall oil sterol 1 Final report 12/2013available from CIR
Tallow 1 greater than 50% JACT 9(2):153-64,1990 confirmed
06/06
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Tallowamide DEA 1 safe in the present practices ofuse and concentration when
formulated to be non-irritatingand when the levels of freeDEA do not exceed those
considered safe int the CIRsafety assessment of DEAand its salts; should not beused in cosmetic products
IJT 32(S1):36-58,2013
Tallowamide MEA 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
IJT 34(S1): 18-34,2015
Tallowamidopropyl betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
IJT 31(S1):77-111,2012
Tallowamidopropyl dimethylamine 1 not in current use* safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
Final report 06/2014available from CIR
Tallow Betaine 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2014available from CIR
Talloweth-18 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Talloweth-4 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Talloweth-5 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Talloweth-6 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Talloweth-7 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Tallow Glyceride 1 up to 25% JACT 9(2):153-64,1990 confirmed
06/06
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Tallow Glycerides 1 JACT 9(2):153-64,1990 confirmed
06/06Tallowtrimonium chloride 1 IJT 31(S3): 296-341
(2012)Tamarindus Indica Seed Gum 1 Final report 09/2015
available from CIRTapioca Starch 1 Final report 09/2015
available from CIRTapioca Starch Crosspolymer 1 Final report 09/2015
available from CIRTBHQ (originally t-Butyl Hydroquinone) (Amended) 1 safe up to 0.1% JACT 10(1):1-7,
1991 JACT5(5):329-51, 1986
(Original report)t-Butyl Acetate 1 up to 10% IJT 31(S1):112-136,
2012t-Butyl Alcohol (Amended) 1 up to 0.5% IJT 24 (2):1-20, 2005
(Amended) JACT8(4):627-41, 1989(Original Report)
t-Butyl Hydroquinone (now TBHQ) (Amended) 1 0.1% JACT 10(1):1-7,1991 JACT
5(5):329-51, 1986(Original report)
t-Butyl Methacrylate 1 safe in nail enhancementproducts when skin contact isavoided; products containing
this ingredient should beaccompanied with directions
to avoid skin contactbecause of the sensitizingpotential of methacrylates
IJT 24(S5):53-100,2005
TEA-Alginate 1 Final report 09/2015available from CIR
TEA-C10-15 Alkyl Sulfate 1 not in current use* safe as used when formulatedto be non-irritating andwhen the levels of freediethanolamine do not
exceed the present practicesof use and concentrationof diethanolamine itself.The ingredients shouldnot be used in cosmeticproducts in which N-nitr
IJT 32(S1): 59-81,2013
TEA-C11-15 Alkyl Sulfate 1 not in current use* safe as used when formulatedto be non-irritating andwhen the levels of free
IJT 32(S1): 59-81,2013
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
diethanolamine do notexceed the present practices
of use and concentrationof diethanolamine itself.The ingredients shouldnot be used in cosmeticproducts in which N-nitr
TEA-C11-15 Pareth Sulfate 1 not in current use* safe as used when formulatedto be non-irritating andwhen the levels of freediethanolamine do not
exceed the present practicesof use and concentrationof diethanolamine itself.The ingredients shouldnot be used in cosmeticproducts in which N-nitr
IJT 32(S1): 59-81,2013
TEA-C12-13 Alkyl Sulfate 1 not in current use* safe as used when formulatedto be non-irritating andwhen the levels of freediethanolamine do not
exceed the present practicesof use and concentrationof diethanolamine itself.The ingredients shouldnot be used in cosmeticproducts in which N-nitr
IJT 32(S1): 59-81,2013
TEA-C12-13 Pareth-3 Sulfate 1 not in current use* safe as used when formulatedto be non-irritating andwhen the levels of freediethanolamine do not
exceed the present practicesof use and concentrationof diethanolamine itself.The ingredients shouldnot be used in cosmeticproducts in which N-nitr
IJT 32(S1): 59-81,2013
TEA-C12-14 Alkyl Sulfate 1 not in current use* safe as used when formulatedto be non-irritating andwhen the levels of freediethanolamine do not
exceed the present practicesof use and concentrationof diethanolamine itself.The ingredients shouldnot be used in cosmeticproducts in which N-nitr
IJT 32(S1): 59-81,2013
TEA-C12-15 Alkyl Sulfate 1 not in current use* safe as used when formulatedto be non-irritating and
IJT 32(S1): 59-81,2013
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
when the levels of freediethanolamine do not
exceed the present practicesof use and concentrationof diethanolamine itself.The ingredients shouldnot be used in cosmeticproducts in which N-nitr
TEA-Canolate 1 not in current use* safe as used when formulatedto be non-irritating andwhen the levels of freediethanolamine do not
exceed the present practicesof use and concentrationof diethanolamine itself.The ingredients shouldnot be used in cosmeticproducts in which N-nitr
IJT 32(S1): 59-81,2013
TEA-Cocoate 1 safe as used when formulatedto be non-irritating andwhen the levels of freediethanolamine do not
exceed the present practicesof use and concentrationof diethanolamine itself.The ingredients shouldnot be used in cosmeticproducts in which N-nitr
IJT 32(S1): 59-81,2013
TEA-Coco-Sulfate 1 not in current use* safe as used when formulatedto be non-irritating andwhen the levels of freediethanolamine do not
exceed the present practicesof use and concentrationof diethanolamine itself.The ingredients shouldnot be used in cosmeticproducts in which N-nitr
IJT 32(S1): 59-81,2013
TEA-cocoyl alaninate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
TEA-cocoyl glutamate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
TEA-cocoyl glutaminate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
TEA-Cocoyl-Hydrolyzed Collagen (formerlyTriethanolamine-Coco-Hydrolyzed Animal Protein)
1 up to 50% JACT 2(7):75-86,1983 confirmed
11/02 IJT 24(S1):82-85, 2005
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
TEA-Dextrin Octenylsuccinate 1 Final report 09/2015available from CIR
TEA-Dodecylbenzenesulfonate (amended) 1 up to 5% JACT 12(3):279-309,1993 (original
report); IJT 29 (S4)288-305, 2010
TEA-EDTA 1 not in current use* IJT 21(S2):95- 142,2002
TEA-Glyceryl Dimaleate 1 not in current use* safe as used when formulatedto be non-irritating andwhen the levels of freediethanolamine do not
exceed the present practicesof use and concentrationof diethanolamine itself.The ingredients shouldnot be used in cosmeticproducts in which N-nitr
IJT 32(S1): 59-81,2013
TEA-Hydrochloride 1 safe as used when formulatedto be non-irritating andwhen the levels of freediethanolamine do not
exceed the present practicesof use and concentrationof diethanolamine itself.The ingredients shouldnot be used in cosmeticproducts in which N-nitr
IJT 32(S1): 59-81,2013
TEA-Hydrogenated Cocoate 1 not in current use* safe as used when formulatedto be non-irritating andwhen the levels of freediethanolamine do not
exceed the present practicesof use and concentrationof diethanolamine itself.The ingredients shouldnot be used in cosmeticproducts in which N-nitr
IJT 32(S1): 59-81,2013
TEA-hydrogenated tallowoyl glutamate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
TEA-Isostearate 1 safe as used when formulatedto be non-irritating andwhen the levels of freediethanolamine do not
exceed the present practicesof use and concentrationof diethanolamine itself.The ingredients should
IJT 32(S1): 59-81,2013
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
not be used in cosmeticproducts in which N-nitr
TEA-Lactate 1 when used as an AHAingredient, safe for use atconcentrations less thanor equal to10%, at finalformulation pH greater
than or equal to3.5, whenformulated to avoid increasing
sun sensitivity or whendirections for use include thedaily use of sun protection.
These ingredients are safe for
IJT 17(S1):1-242,1998; IJT 32(S1):
59-81, 2013
TEA-Laurate 1 safe as used when formulatedto be non-irritating andwhen the levels of freediethanolamine do not
exceed the present practicesof use and concentrationof diethanolamine itself.The ingredients shouldnot be used in cosmeticproducts in which N-nitr
IJT 32(S1): 59-81,2013
TEA-Laurate/Myristate 1 not in current use* safe as used when formulatedto be non-irritating andwhen the levels of freediethanolamine do not
exceed the present practicesof use and concentrationof diethanolamine itself.The ingredients shouldnot be used in cosmeticproducts in which N-nitr
IJT 32(S1): 59-81,2013
TEA-Laureth Sulfate 1 safe as used when formulatedto be non- irritating andwhen the levels of freediethanolamine do not
exceed the present practicesof use and concentrationof diethanolamine itself.The ingredients shouldnot be used in cosmeticproducts in which N-nitr
IJT 32(S1): 59-81,2013
TEA-lauroyl/myristoyl aspartate* 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
TEA-lauroyl collagen amino acids 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
TEA-lauroyl glutamate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
TEA-lauroyl keratin amino acids* 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
TEA-Lauryl Sulfate 1 safe up to 10.5% JACT 1 (4):143-67,1982; IJT 32(S1):
59-81, 2013TEA-Myristate 1 safe as used when formulated
to be non-irritating andwhen the levels of freediethanolamine do not
exceed the present practicesof use and concentrationof diethanolamine itself.The ingredients shouldnot be used in cosmeticproducts in which N-nitr
IJT 32(S1): 59-81,2013
TEA-Oleate 1 not in current use* safe as used when formulatedto be non-irritating andwhen the levels of freediethanolamine do not
exceed the present practicesof use and concentrationof diethanolamine itself.The ingredients shouldnot be used in cosmeticproducts in which N-nitr
IJT 32(S1): 59-81,2013
TEA-Oleyl Sulfate 1 not in current use* safe as used when formulatedto be non-irritating andwhen the levels of freediethanolamine do not
exceed the present practicesof use and concentrationof diethanolamine itself.The ingredients shouldnot be used in cosmeticproducts in which N-nitr
IJT 32(S1): 59-81,2013
TEA-Palmitate 1 safe as used when formulatedto be non-irritating andwhen the levels of freediethanolamine do not
exceed the present practicesof use and concentrationof diethanolamine itself.The ingredients shouldnot be used in cosmeticproducts in which N-nitr
IJT 32(S1): 59-81,2013
TEA-PEG-3 Cocamide Sulfate 1 not in current use* safe as used when formulatedto be non-irritating andwhen the levels of freediethanolamine do not
IJT 32(S1): 59-81,2013
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
exceed the present practicesof use and concentrationof diethanolamine itself.The ingredients shouldnot be used in cosmeticproducts in which N-nitr
TEA-Salicylate 1 safe when formulated toavoid irritation and to avoidincreasing sun sensitivity,
or when increased sunsensitivity would be expected,directions for use include thedaily use of sun protection.
IJT 22(3):1-108
TEA Sorbate 1 safe as used when formulatedto be non-irritating andwhen the levels of freediethanolamine do not
exceed the present practicesof use and concentrationof diethanolamine itself.The ingredients shouldnot be used in cosmeticproducts in which N-nitr
IJT 32(S1): 59-81,2013
TEA Stearate 1 safe for use in rinse-offproducts; but 15% in leave-
on products; and should not beused with N-nitrosating agents
JACT 14(3): 240-8,1995; IJT 32(S1):
59-81, 2013
TEA Sulfate 1 safe as used when formulatedto be non-irritating andwhen the levels of freediethanolamine do not
exceed the present practicesof use and concentrationof diethanolamine itself.The ingredients shouldnot be used in cosmeticproducts in which N-nitr
IJT 32(S1): 59-81,2013
TEA-Tallate 1 safe as used when formulatedto be non-irritating andwhen the levels of freediethanolamine do not
exceed the present practicesof use and concentrationof diethanolamine itself.The ingredients shouldnot be used in cosmeticproducts in which N-nitr
IJT 32(S1): 59-81,2013
TEA-Tridecylbenzenesulfonate (amended) 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 29 (S4) 288-305,2010
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
TEA-Undecylenate 1 not in current use* safe as used when formulatedto be non-irritating andwhen the levels of freediethanolamine do not
exceed the present practicesof use and concentrationof diethanolamine itself.The ingredients shouldnot be used in cosmeticproducts in which N-nitr
IJT 32(S1): 59-81,2013
Tetradecyleicosyl Stearate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Tetradecyloctadecyl Behenate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Tetradecyloctadecyl Hexyldecanoate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Tetradecyloctadecyl Myristate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
IJT29(S3) :162-186,2010;
final report 03/2013available from CIR
Tetradecyloctadecyl Stearate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Tetradecylpropionates 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Tetrahydrofurfuryl Methacrylate 1 safe in nail enhancementproducts when skin contact isavoided;products should beaccompanied with directions
to avoid skin contactbecause of the sensitizingpotential of methacrylates
IJT 24(S5):53-100,2005
Tetrasodium EDTA 1 less than 1% IJT 21(S2):95- 142,2002
Theobroma Cacao (Cocoa) Seed Butter 1 0.000002 to 37% Final report 03/11available from CIR
Theobroma Grandiflorum Seed Butter 1 0.00005 to 7% Final report 03/11available from CIR
Thiodipropionic Acid (amended) 1 safe for use in cosmeticformulations when formulated
to be non-irritating
IJT 29 (S3): 137-150,2010
Thioglycolic Acid (amended) 1 safe for use in hairstraighteners permanentwaves, tonics, dressings,and so forth, wave sets,other noncoloring hair
products, and hair dyes andcolors, at concentrationsup to 15.2%; hairdressers
JACT 10(1):135-92,1991 (original
report); IJT28(S3):68-133, 2009
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
should avoid skin contactand minimize consumer skin
Threonine 1 0.00002 to 0.05% IJT 32(S4):41-64,2013
Thymol (amended) 1 up to 0.5% IJT 25(S1):29-127,2006
Tin(IV) Oxide 1 0.000003 to 1.3% IJT 33(S4):40-46,2014
Tocopherol 1 less than or equal to 5% IJT 21 (S3):51-116,2002; Final report03/2014 available
from CIRTocophersolan 1 less than or equal to 0.2% IJT 21(S3):51-116,
2002; Final report03/2014 available
from CIRTocopheryl Acetate 1 less than or equal to 36%
(100% in Vitamin E oil)IJT 21(S3):51-116,2002; Final report03/2014 available
from CIRTocopheryl Linoleate 1 less than or equal to 2% IJT 21(S3):51- 116,
2002; Final report03/2014 available
from CIRTocopheryl Linoleate/Oleate 1 not in current use* IJT 21(S3):51-116,
2002; Final report03/2014 available
from CIRTocopheryl Nicotinate 1 less than or equal to 1% IJT 21(S3):51 -116,
2002; Final report03/2014 available
from CIRTocopheryl Phosphate 1 not in current use* Final report 03/2014
available from CIRTocopheryl Succinate 1 concentration not reported* IJT 21(S3):51-116,
2002; Final report03/2014 available
from CIRTocotrienols 1 Final report 03/2014
available from CIRToluene 1 up to 50% in nail
care productsJACT 6(1):77-120,
1987 confirmed03/05 IJT 25(S2),
2006Toluene-2,5-Diamine (amended) 1 up to 3% JACT 11(4):423-45,
1992 (originalreport); IJT
29(S2):61-83, 2010
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Toluene-2,5-Diamine Sulfate (amended) 1 up to 4% JACT 11(4):423-45,1992 (original
report); IJT29(S2):61-83, 2010
Toluene-3,4-Diamine (amended) 1 JACT 11(4):423-45,1992 (original
report); IJT29(S2):61-83, 2010
Toluenesulfonamide/Formaldehyde Resin (aka Tosylamide/Formaldehyde Resin)
1 up to 13% JACT 5(5):471-490,1986 confirmed
09/04 IJT 25(S2),2006
Toluenesulfonamide/Formaldehyde Resin-80 1 not in current use* JACT 5(5):471-490,1986 confirmed
09/04 IJT 25(S2),2006
Toluene Sulfonic Acid 1 not in current use* IJT 30(S3):270-283,2011
Torreya Nucifera Seed Oil 1 not in use at the time* Final report 03/11available from CIR
Tragacanth (Astragalus Gummifer) Gum 1 up to 3% JACT 6(1):1-22,1987 confirmed
09/04 IJT 25(S2),2006
Trehalose 1 Final report 03/2014available from CIR
Triacetin 1 up to 4% IJT 22(S2):1-10,2003
Triarachidin 1 not in current use* IJT 20 (S4):61-94,2001
Tribehenin 1 up to 6% IJT 20(S4):61-94,2001
Tributyl citrate 1 0.0005 to 9% IJT 33 (S2): 16-46,2014
Tri-C12-13 alkyl citrate 1 concentration not reported* IJT 33 (S2): 16-46,2014
Tri-C14-15 alkyl citrate 1 0.1 to 5% in leave- on IJT 33 (S2): 16-46,2014
Tricaprin 1 not in current use* IJT 20(S4):61- 94,2001
Tricaprylin 1 concentration not reported* IJT 20(S4):61-94,2001
tricaprylyl/capryl trimellitate* 1 safe when formulatedto be non-irritating
Final report 09/2015available from CIR
Tricaprylyl citrate 1 0.3 to 27% IJT 33 (S2): 16-46,2014
Tricetyl phosphate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2014available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Trichloroethane 1 safe as a solvent, but notin use at the time; EPA has
banned all but essentialuses and FDA has said that
aerosol uses are not essential
IJT 27(S4): 107-138,2008
Triclosan 1 0.04 to 0.3% Final report 12/10available from CIR
Trideceth-10 1 safe for cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Trideceth-12 1 safe for cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Trideceth-15 1 safe for cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Trideceth-18 1 safe for cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Trideceth-2 1 safe for cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Trideceth-20 1 safe for cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Trideceth-21 1 safe for cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Trideceth-2 carboxamide MEA 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
IJT 34(S1): 18-34,2015
Trideceth-3 1 safe for cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Trideceth-4 1 safe for cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Trideceth-5 1 safe for cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Trideceth-50 1 safe for cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Trideceth-6 1 safe for cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Trideceth-7 1 safe for cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Trideceth-8 1 safe for cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Trideceth-9 1 safe for cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Tridecyl Behenate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Tridecyl Cocoate (amended) 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
IJT 30(S1):5S-16S;Final report 06/13
available from CIRTridecyl Erucate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIRTridecyl Ethylhexanoate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIRTridecyl Isononanoate 1 9% safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIRTridecyl Laurate 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIRTridecyl Myristate 1 not in use at the time* safe for use in cosmetics when
formulated to be non-irritatingIJT
29(S3) :162-186,2010;Final report 03/2013
available from CIRTridecyl Neopentanoate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIRTridecyl Salicylate 1 safe when formulated to
avoid irritation and to avoidincreasing sun sensitivity,
or when increased sunsensitivity would be expected,directions for use include thedaily use of sun protection.
IJT 22(3):1-108
Tridecyl Stearate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
tridecyl trimellitate 1 safe when formulatedto be non-irritating
Final report 09/2015available from CIR
Trierucin 1 not in current use* IJT 20(S4):61- 94,2001
Triethanolamine 1 safe for use in rinse-offproducts; but 5% in leave-
on cosmetic products;and should not be used
JACT 2(7):183-235,1983; IJT 32(S1):
59-81, 2013
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
in products containingN-nitrosating agents
Triethanolamine Cocoyl Hydrolyzed Collagen (formerlyTriethanolamine-Coco-Hydrolyzed Animal Protein)
1 up to 50% JACT 2(7):75-86,1983 confirmed
11/02 IJT 24(S1):82-85, 2005
Triethyl citrate 1 0.0008 to 6% IJT 33 (S2): 16-46,2014
Triethylene Glycol 1 0.0006 to 0.2% Amended FinalReport 06/10 -
available from CIRTriethylene Glycol Dimethacrylate 1 safe in nail enhancement
products when skin contact isavoided; products containing
this ingredient should beaccompanied with directions
to avoid skin contactbecause of the sensitizingpotential of methacrylates
IJT 24(S5):53-100,2005
Triethylhexanoin (aka Trioctanoin) Triisononanoin 1 concentration not reported* IJT 20(S4):61-94,2001
Triethylhexyl citrate 1 concentration not reported* IJT 33 (S2): 16-46,2014
triethylhexyl trimellitate 1 safe when formulatedto be non-irritating
Final report 09/2015available from CIR
Trifluoropropyl dimethicone/PEG-10 crosspolymer 1 not in current use* IJT 33 (S2): 65-115,2014
Trifluoropropyl dimethicone/trifluoropropyldivinyldimethicone crosspolymer
1 not in current use* IJT 33 (S2): 65-115,2014
Trifluoropropyl dimethicone/vinyl trifluoropropyldimethicone/silsesquioxane crosspolymer
1 not in current use* IJT 33 (S2): 65-115,2014
Trifluoropropyldimethyl/trimethylsiloxysilicate 1 safe when formulatedand delivered in the
final product not to beirritating or sensitizingto the respiratory tract
IJT 31(S1):5-24(2013)
Trigonella foenum-graecum hydroxypropyltrimoniumchloride
1 not in current use* IJT 34 (S1): 35-65,2015
Triheptanoin 1 not in current use* IJT 20 (S4):61-94,2001
Triheptylundecanoin 1 not in current use* IJT 20(S4):61-94,2001
Trihexyldecyl citrate 1 not in current use* IJT 33 (S2): 16-46,2014
Trihydroxystearin 1 up to 5% IJT 19(S1):89-94,2000
Triisocetyl citrate 1 0.6to 3% in leave-on IJT 33 (S2): 16-46,2014
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
triisodecyl trimellitate 1 safe when formulatedto be non-irritating
Final report 09/2015available from CIR
Triisopalmitin 1 not in current use* IJT 20 (S4):61-94,2001
Triisopropanolamine 1 safe for use in cosmeticproducts; but should not beused in products containing
N-nitrosating agents
JACT 6(1):53-76,1987 confirmed
12/04 IJT 25(S2),2006
Triisopropyl citrate 1 not in current use* IJT 33 (S2): 16-46,2014
Triisostearin 1 less than 40% IJT 20(S4):61- 94,2001
Triisostearyl citrate 1 0.3 to 80% in leave-on, concentration notreported for rinse-off
Final report 03/12available from CIR
triisotridecyl trimellitate 1 safe when formulatedto be non-irritating
Final report 09/2015available from CIR
Trilaurin 1 less than 50% IJT 20(S4):61-94,2001
Trilauryl citrate 1 not in current use* Final report 03/12available from CIR
Trilauryl phosphate 1 not in current use* Final report 09/2014available from CIR
Trilinolein 1 concentration not reported* IJT 20(S4):61-94,2001
Trimethylolpropane Trimethacrylate 1 safe in nail enhancementproducts when skin contact isavoided; products containing
this ingredient should beaccompanied with directions
to avoid skin contactbecause of the sensitizingpotential of methacrylates
IJT 24(S5):53-100,2005
Trimethylsiloxysilicate 1 safe when formulatedand delivered in the
final product not to beirritating or sensitizingto the respiratory tract
IJT 31(S1):5-24(2013)
Trimethylsiloxysilicate/ dimethicone crosspolymer 1 not in current use* IJT 33 (S2): 65-115,2014
Trimethylsiloxysilicate/dimethiconol crosspolymer 1 up to 2% Final report 12/10available from CIR
Trimyristin 1 concentration not reported* IJT 20(S4):61-94,2001
Trioctyldodecyl citrate 1 1 to 30% in leave- on Final report 03/12available from CIR
Triolein 1 not in current use* IJT 20(S4):61- 94,2001
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Trioleyl citrate 1 not in current use* Final report 03/12available from CIR
Trioleyl phosphate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2014available from CIR
Tripalmitin 1 concentration not reported* IJT 20(S4):61-94,2001
Tripalmitolein 1 not in current use* IJT 20 (S4):61-94,2001
Tripeptide-1 1 Final report 06/2014available from CIR
Tripotassium EDTA 1 concentration not reported* IJT 21(S2):95-142,2002
Tripropylene Glycol 1 safe when formulatedto be non- irritating
IJT 31(2) 245-260,2012
Triricinolein 1 not in current use* IJT 20 (S4):61-94,2001
Trisodium EDTA 1 less than 1% IJT 21(S2):95- 142,2002
Trisodium Glycyrrhizate 1 not in current use* IJT 26(S2):79-112,2007
Trisodium HEDTA 1 less than 1% IJT 21(S2):95- 142,2002
Tristearin 1 concentration not reported* IJT 20(S4):61-94,2001
Tristearyl citrate 1 not in current use* Final report 03/12available from CIR
Tristearyl phosphate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2014available from CIR
Triticum Aestivum (Wheat) Germ Oil 1 not in use at the time* Final report 03/11available from CIR
Triticum Vulgare (Wheat) Germ Oil 1 0.0001 to 28% Final amended report03/11 available
from CIR; JEPT4(4):33-45, 1980;
re-review IJT22(S1):1-35, 2003
Triticum Vulgare (Wheat) Germ Oil Unsaponifiables 1 up to 0.2% Final report 03/11available from CIR
Triticum Vulgare (Wheat) Gluten 1 less than or equal to 1% JEPT 4(4):5-17, 1980confirmed 06/01 IJT
22(S1):1-35, 2003Triticum Vulgare (Wheat) Kernel Flour 1 up to 1% JEPT 4(4):19-32,
1980 confirmed06/01 IJT
22(S1):1-35, 2003Triticum Vulgare(Wheat) Starch 1 JEPT 4(4):19-32,
1980 confirmed06/01 IJT
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Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
22(S1):1-35, 2003;Final report 09/2015
available from CIRTriundecanoin 1 not in current use* IJT 20 (S4):61-94,
2001Tromethamine 1 Final report 09/2013
available from CIRTryptophan 1 0.00% IJT 32(S4):41-64,
2013Tyrosine 1 0.0005 to 1% IJT 32(S4):41-64,
2013Umbilical Extract 1 if used, should not deliver
any metabolic/endocrineactivity, and they must be
free of detectable pathogenicviruses or infectious agents
IJT 21(S1):81-91,2002
Undeceth-11 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Undeceth-3 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Undeceth-40 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Undeceth-5 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Undeceth-7 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Undeceth-8 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Undeceth-9 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Undecylenamide DEA 1 safe in the present practices ofuse and concentration when
formulated to be non-irritatingand when the levels of freeDEA do not exceed those
considered safe int the CIRsafety assessment of DEAand its salts; should not beused in cosmetic products
Final amended report09/11 available from
CIR
Undecylenamide MEA 1 safe in the present practicesof use and concentration
IJT 34(S1): 18-34,2015
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Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
Undecylenamidopropyl betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
IJT 31(S1):77-111,2012
Undecyleneth-6 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
undecylenoyl collagen amino acids 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available for CIR
undecylenoyl glycine 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available for CIR
Undecylenoyl Inulin 1 Final report 09/2015available from CIR
undecylenoyl phenylalanine 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available for CIR
undecylenoyl wheat amino acids* 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available for CIR
Undecylenoyl xanthan gum 1 not in current use* Final report 09/12available from CIR
Undecyl glucoside 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 32 (S3): 22-48,2013
Urea 1 up to 10% IJT 24(S3):1-56,2005
Urethane Methacrylate 1 safe in nail enhancementproducts when skin contact isavoided; products containing
this ingredient should beaccompanied with directions
to avoid skin contactbecause of the sensitizingpotential of methacrylates
IJT 24(S5):53-100,2005
Urocanic Acid 1 JACT 14(5):386-423,1995
VA/Butyl Maleate/Isobornyl Acrylate Copolymer 1 safe for use whenformulated to avoid irritation
IJT 21(S3):1-50,2002
VA/Crotonates Copolymer (formerly Vinyl Acetate/CrotonicAcid Copolymer)
1 up to 11% JACT 2(5):125-140,1983 confirmed
06/03 IJT 24(S1):101-102, 2005
Vaccinium Corymbosum (Blueberry) Seed Oil 1 not in use at the time* Final report 03/11available from CIR
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Vaccinium Macrocarpon (Cranberry) Seed Oil 1 0.002 to 2% Final report 03/11available from CIR
Vaccinium Myrtillus Seed Oil 1 0.01 to 0.1% Final report 03/11available from CIR
Vaccinium Vitis-Idaea Seed Oil 1 concentration not reported* Final report 03/11available from CIR
Valine 1 0.0004 to 1% IJT 32(S4):41-64,2013
Vegetable (Olus) Oil 1 0.0005 to 31% Final report 03/11available from CIR
Vegetable Amino Acids 1 IJT 33(S4):5-12,2014
Vinyl Caprolactam/PVP/ Dimethylaminoethyl MethacrylateCopolymer
1 safe for use whenformulated to avoid irritation
IJT 21(S3):1-50,2002
Vinyl Dimethicone 1 not in current use* IJT 22 (S2):11-35,2003
Vinyl dimethicone/lauryl/behenyl dimethicone crosspolymer 1 not in current use* IJT 33 (S2): 65-115,2014
Vinyl dimethicone/lauryl dimethicone crosspolymer 1 0.09 to 2% IJT 33 (S2): 65-115,2014
Vinyl dimethicone/methicone silsesquioxane crosspolymer 1 0.1 to 20% IJT 33 (S2): 65-115,2014
Vinyldimethyl/trimethylsiloxysilicate/dimethiconecrosspolymer
1 not in current use* IJT 33 (S2): 65-115,2014
Vinyldimethyl/trimethylsiloxysilicate stearyl dimethiconecrosspolymer
1 not in current use* IJT 33 (S2): 65-115,2014
Vitis Vinifera (Grape) 1 0.10% IJT 33(S3):48-83,2014
Vitis Vinifera (Grape) bud extract 1 0.08% IJT 33(S3):48-83,2014
Vitis Vinifera (Grape) flower extract 1 not in current use* IJT 33(S3):48-83,2014
Vitis Vinifera (Grape) fruit extract 1 0.000001 to 2% IJT 33(S3):48-83,2014
Vitis Vinifera (Grape) fruit powder 1 concentration not reported* IJT 33(S3):48-83,2014
Vitis Vinifera (Grape) fruit water 1 0.7 to 0.8% IJT 33(S3):48-83,2014
Vitis Vinifera (Grape) juice 1 0.01 to 2% IJT 33(S3):48-83,2014
Vitis Vinifera (Grape) juice extract 1 concentration not reported* IJT 33(S3):48-83,2014
Vitis Vinifera (Grape) leaf/seed/skin extract 1 not in current use* IJT 33(S3):48-83,2014
Vitis Vinifera (Grape) leaf extract 1 0.01 to 3% IJT 33(S3):48-83,2014
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Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Vitis Vinifera (Grape) leaf oil 1 not in current use* IJT 33(S3):48-83,2014
Vitis Vinifera (Grape) leaf water 1 not in current use* IJT 33(S3):48-83,2014
Vitis Vinifera (Grape) leaf wax 1 not in current use* IJT 33(S3):48-83,2014
Vitis Vinifera (Grape) root extract 1 not in current use* IJT 33(S3):48-83,2014
Vitis Vinifera (Grape) seed 1 0.05 to 0.08% IJT 33(S3):48-83,2014
Vitis Vinifera (Grape) seed extract 1 0.00002 to 0.2%l. IJT 33(S3):48-83,2014
Vitis Vinifera (Grape) Seed Oil 1 0.001 to 43% IJT 33(S3):48-83,2014
Vitis Vinifera (Grape) Seed powder 1 concentration not reported* IJT 33(S3):48-83,2014
Vitis Vinifera (Grape) shoot extract 1 0.00% IJT 33(S3):48-83,2014
Vitis Vinifera (Grape) skin extract 1 not in current use* IJT 33(S3):48-83,2014
Vitis Vinifera (Grape) skin powder 1 not in current use* IJT 33(S3):48-83,2014
Vitis Vinifera (Grape) vine extract 1 IJT 33(S3):48-83,2014
Vitis Vinifera (Grape) vine sap 1 not in current use* IJT 33(S3):48-83,2014
VP/VA Copolymer 1 up to 12% JACT 2(5):141-59,1983 confirmed
09/03Watermelon seed oil PEG-8 esters 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014Welan Gum 1 not in current use* Final report 09/12
available from CIRWheat Amino Acids 1 IJT 33(S4):5-12,
2014Wheat Germ Acid 1 concentration not reported* Final report 03/11
available from CIRWheat germamide DEA 1 safe in the present practices of
use and concentration whenformulated to be non-irritating
and when the levels of freeDEA do not exceed those
considered safe int the CIRsafety assessment of DEAand its salts; should not beused in cosmetic products
IJT 32(S1):36-58,2013
Wheat germamidopropyl betaine 1 safe for use in cosmeticswhen formulated to be
IJT 31(S1):77-111,2012
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Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
non-sensitizing, whichmay be based on a
quantitative risk assessmentWheat germamidopropyl dimethylamine 1 not in current use* safe for use in cosmetics
when formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
Final report 06/2014available from CIR
Wheat Germ Glycerides 1 up to 25% JEPT 4(4):5- 17,1980 confirmed
06/01 IJT22(S1):1-35, 2003
Wheat Germ Oil PEG-40 Butyloctanol Esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Wheat Germ Oil PEG-8 Esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Wild Yam (Dioscorea Villosa) Root Extract 1 up to 15% of max2% plant solids
IJT 23(S2):49-54,2004
Xanthan Gum 1 0.00001 to 6% Final report 09/12available from CIR
Xanthan Gum Crosspolymer 1 0.03 to 5% Final report 09/12available from CIR
Xanthan Hydroxypropyltrimonium chloride 1 not in current use* Final report 09/12available from CIR
Xylene Sulfonic Acid 1 not in current use* IJT 30(S3):270-283,2011
Xylobiose 1 Final report 03/2014available from CIR
Xyloglucan 1 Final report 09/2015available from CIR
Xylose 1 Final report 03/2014available from CIR
Yeast amino acids 1 not in current use* IJT 33(S4):5-12,2014
Zea Mays (Corn) Cob Meal 1 up to 3% IJT 30 (S1): 17-39,2011
Zea Mays (Corn) Cob Powder 1 up to 10% IJT 30 (S1): 17-39,2011
Zea Mays (Corn) Fruit 1 not in current use* IJT 30 (S1): 17-39,2011
Zea Mays (Corn) Germ Extract 1 concentration not reported* IJT 30 (S1): 17-39,2011
Zea Mays (Corn) Germ Oil 1 0.2 to 25% Final amended report03/11 available
from CIR; IJT 30(S1): 17-39, 2011
(original)
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Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Zea Mays (Corn) Gluten Protein 1 0.03 to 0.1% IJT 30 (S1): 17-39,2011
Zea Mays (Corn) Kernel Extract 1 up to 0.5% IJT 30 (S1): 17-39,2011
Zea Mays (Corn) Kernel Meal 1 up to 3% Final amended report03/11 available
from CIR; IJT 30(S1): 17-39, 2011
(original)Zea Mays (Corn) Oil 1 up to 14% Final amended report
03/11 availablefrom CIR; IJT 30(S1): 17-39, 2011
(original)Zea Mays (Corn) Oil Unsaponifiables 1 concentration not reported* Final amended report
03/11 availablefrom CIR; IJT 30(S1): 17-39, 2011
(original)Zea Mays (Corn) Seed Flour 1 concentration not reported* IJT 30 (S1): 17-39,
2011Zea Mays (Corn) Silk Extract 1 up to 0.1% IJT 30 (S1): 17-39,
2011Zea Mays (Corn) Starch 1 up to 99% IJT 30 (S1): 17-39,
2011Zeolite 1 not in current use* IJT 22(S1):37- 102,
2003Zinc Acetate 1 concentration not reported* IJT 31(S1):112-136,
2012Zinc borosilicate 1 not in current use* IJT 32(S3): 65-72,
2013Zinc citrate 1 0.05% in leave-on;
0.3 to 2% in rinse-offIJT 33 (S2): 16-46,
2014Zinc Coceth Sulfate 1 safe in the present practices of
use and concentration whenformulated to be non-irritating
IJT29(S3) :151-161,2010
Zinc Coco-Sulfate 1 not in current use* IJT 29(S2): 115-132,2010
Zinc lauroyl aspartate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available for CIR
Zinc Myristate 1 up to 20% IJT29(S3) :162-186,2010
Zinc Phenolsulfonate 1 up to 4% JACT 5(5):373-90,1986 confirmed
06/04 IJT 25(S2),2006
Zinc Ricinoleate 1 up to 2% IJT 26(S3): 31-772007
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Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Zinc Stearate 1 up to 51% JACT 1(2):143-77,1982 confirmed
11/01 IJT22(S1):1-35, 2003
Zirconium Silicate 1 not in current use * IJT 22(S1):37-102,2003
† Please consider the most recent findings only. Previous citations are only offered for reference purposes.* Were the ingredient to be used in the future, the expectation is that it would be used at concentrations comparable to others in the group.** Safety as a hair dye ingredient was reaffirmed in 2004; but the Panel noted that the use of p-Phenylenediamine with henna (so-called dark henna) for temporary tattoos is unapproved by FDA — p-Phenylenediamine is a knownsensitizer, highly inappropriate for such use as evidenced by reports of severe adverse skin reactions to dark henna temporary tattoos.*** in addition, "red" panax ginseng root extract and "white" panax ginseng root extract are reported to be used, within the given concentration range, but they are not separately listed as cosmetic ingredients**** S - safe in the present practices of use and concentration SQ - safe for use in cosmetics, with qualifications I - the available data are insufficient to support safety Z - the available data are insufficient to support safety, but theingredient is not in current use U - the ingredient is unsafe for use in cosmetics UNS - ingredients for which the data are insufficient and their use in cosmetics is not supported Note: the number given is the number of ingredientsin the given category in that row