quinic acid 천연물약품화학연구실 석 사 2 기 장 성 완. contents ♠ quinic acid ♠ j...
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contents
♠ Quinic acid
♠ Journal
1. Molecule2. Helvetica Chimica Acta3. Chemistry & Biodiversity4. Bioorganic & Medicinal Chemistry5. Food Chemistry6. Journal of Natural Products
Quinic acid Quinic acid is a cyclitol, a cyclic polyol, and a cyclohexane-
carboxylic acid.
a crystalline acid obtained from cinchona bark, coffee beans, and other plant products and made synthetically by hydrolysis of chlorogenic acid. Quinic acid is also implicated in the perceived acidity of coffee.
isolated for the first time in the 1800s by French pharmacist Nico-las Vauquelin and further reactions from this acid to synthesize other compounds were studied by German chemist E. Lautemann in 1863.
A medication for the treatment of influenza A and B strains called Tamiflu has been successfully developed and launched into the market
♠ Journal
1. Molecule2. Helvetica Chimica Acta3. Chemistry & Biodiversity4. Bioorganic & Medicinal Chemistry5. Food Chemistry6. Journal of Natural Products
아토피와일광화상 치료
항암 / 항산화 활성 유용물질 연구활발
Bathochromic shift 를 통해 ortho 치환 잔기 , Caffeoyl 치환체 확인
MS 로 caffeoyl moiety, free caffeic acid 확인2 쌍의 이중선 - two (E)-olefinic protonAromatic region – ABX spin sys-tem
Quinic acid 특징 peak 확인
MeO peak 확인
치환체는 free quinic acid, chloro-genic acid 의 NMR data 로 비교