Question 1 (1 point) The pre-TcR is:Question 1 options:

a)  Composed of a TcR beta chain and CD3 complex

b)  Signals proliferation of clones expressing the pre-TcR complexc)  Stimulates permission for TcR alpha-chain locus rearrangementd)  all of the above

SaveQuestion 2 (1 point) Which of these T-cell subsets is usually required for B-cell activationQuestion 2 options:

a)  T-helper cells.b)  T-cytotoxic cells.c)  both types of cells.d)  neither of these cell types.

SaveQuestion 3 (1 point) Caspases are important in the following situations:Question 3 options:

a)  Fas-FasL interactions

b)  Release of cytochrome c from the mitochondrion of cells

c)  Apoptotic pathways

d)  all of the aboveSaveQuestion 4 (1 point) The HLA-H locus is associated with hereditary hemochromatosis of mice.Question 4 options:

a) True

b) FalseSaveQuestion 5 (1 point) You cross a BALB/c (H-2d) mouse with a CBA (H-2k) mouse. The F1 progeny will express class I and II H-2d/kon:Question 5 options:

a)  liver cells and macrophages

b)  macrophages but not liver cells

c)  neither cell type

SaveQuestion 6 (1 point) A monoclonal antibody specific for B2-microglobulin can be used to detect both class I MHC K and D molecules on the cell surface:Question 6 options:

a) Trueb) False

SaveQuestion 7 (1 point) Which of these T-cell subsets can make substantial IL-2:Question 7 options:

a)  T-helper cells.b)  T-cytotoxic cells.c)  both types of cells.d)  neither of these cell types.

SaveQuestion 8 (1 point) Class II MHC molecules typically bind to longer peptides than do class I molecules:Question 8 options:

a) Trueb) False

SaveQuestion 9 (1 point)

 The following factors are highly relevant to development of T-cells from hematopoietic stem cells:Question 9 options:

a)  The Notch 1 surface markerb)  The IL-7 cytokinesc)  Neither a or bd)  Both a and b

SaveQuestion 10 (1 point) A slide of macrophages was stained by immunofluorescence using a monoclonal antibody for TAP1/TAP2 complex. Which of the following intracellular compartments would exhibit positive staining with this antibody:Question 10 options:

a)  cell surface

b)  endoplasmic reticulum

c)  golgi apparatus

d)  the cells would not be positive because TAP1/TAP2 complex is not expressed in macrophages.

e)  none of the above is correct.