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RAH Intensive Care Unit

©RAH Intensive Care Unit - 8 Sep. 14 of 29

Date Presenter Title

28/1/20 Dr Grieve A Novel Coronavirus from Patients with Pneumonia in China, 2019. NEJM 24/1/20 Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 24/1/20

Dr McArthur Public health issues surrounding Novel Coronavirus & RAH Protocols

21/1/20 Dr Nadkarni New 2019 ANZICS Brain Death & Organ Donation Guidelines

Dr Chapman Systematic review on the treatment of deceased organ donors. Transplantation Reviews 32 (2018) 194–206

Dr Patro Outcomes after DCD donation vs brain death

14/1/20

17/12/19 Dr Kleinig Current stroke trials at RAH - EVACUATE - Glibenclamide in ischaemic stroke

Dr Curtis Christmas Quiz!

10/12/19 Drs Nadkarni & Ohja

Early vs Late coronoary angiogram following non ST elevation cardiac arrest

3/12/19 Dr Grieve Citrate CRRT in Liver Failure

26/11/19 EPAS

19/11/19 ? Prevention of Early Ventilator-Associated Pneumonia after Cardiac Arrest N Engl J Med 2019;381:1831-42.

? HYPERION - Targeted Temperature Management for Cardiac Arrest with Nonshockable Rhythm N Engl J Med 2019; 381:2327-2337

12/11/19 Dr VanLint Haematology in the ICU

5/11/19 ?

29/10/19 Dr Salamon Conservative Oxygen Therapy during Mechanical Ventilation in the ICU. The ICU-ROX investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group (ANZICS-CTG). NEJM;October 14 2019

Dr Lunoe Effects of tranexamic acid on death, disability, vascular occlusive events and other morbidities in patients with acute traumatic brain injury (CRASH-3): a randomised, placebo-controlled trial THE LANCET, VOLUME 394, ISSUE 10210, P1713-1723, NOVEMBER 09, 2019

22/10/19 15/10/19 8/10/19

EPAS Training

1/10/19 Dr Salomon Ticagrelor with or without Aspirin in High-Risk Patients after PCI N Engl J Med 2019; 381:2032-2042

Dr Gawri Effect of Ticagrelor Plus Aspirin, Ticagrelor Alone, or Aspirin Alone on Saphenous Vein Graft Patency 1 Year After Coronary Artery Bypass Grafting JAMA. 2018 Apr 24; 319(16): 1677–1686.



24/9/19 Dr Ohja Gunnerson KJ, Bassin BS, Havey RA, et al. Association of an Emergency Department–Based Intensive Care Unit With Survival and Inpatient Intensive Care Unit Admissions. JAMA Netw Open. 2019;2(7):e197584.

Dr Curtis The Association Between Supra-Physiologic Arterial Oxygen Levels and Mortality in Critically Ill Patients:A Multi-Centre Observational Cohort Study. Am J Respir Crit Care Med. 2019 Dec 1;200(11):1373-1380.

17/9/19 Dr Argent Review of treatment for submassive PE Featuring: -

- PEITHO - MOPPET - MAPPET-3 - Chatterjee et al

Dr Chapman A Doppler Echocardiographic Pulmonary Flow Marker of Massive or Submassive Acute Pulmonary Embolus. J Am Soc Echocardiogr. 2019 Jul;32(7):799-806.

10/9/19 Drs Nadkarni & Curtis

Debate: Early vs Late Renal replacement Therapy Featuring:

- ELAIN - AKIKI - IDEAL

3/9/19 Dr Ohja The effect of high-flow nasal oxygen on hospital length of stay in cardiac surgical patients at high risk for respiratory complications: a randomised controlled trial. Anaesthesia. 2018 Dec;73(12):1478-1488

Dr Argent Effect of a Nurse-Led Preventive Psychological Intervention on Symptoms of Posttraumatic Stress Disorder Among Critically Ill Patients: A Randomized Clinical Trial. JAMA. 2019 Feb 19;321(7):665-675

27/8/19 Dr Kar Diuretic treatment in high-risk acute decompensation of advanced chronic heart failure-bolus intermittent vs. continuous infusion of furosemide: a randomized controlled trial. Clin Res Cardiol. 2019 Jun 29.

Dr Salomon CULPRIT-SHOCK. PCI Strategies in Patients with Acute Myocardial Infarction and Cardiogenic Shock N Engl J Med 2017; 377:2419-2432

20/8/19 Niels Van Mourik The relationship between obesity, calorie delivery and outcome in the critically ill: a posthoc analysis of the TARGET data

13/8/19 Prof Shahid Husain

Infection in Solid Organ Tumours Requiring ICU

6/8/19 Dr Janssen Intensive vs Standard Treatment of Hyperglycaemia and Functional Outcome in Patioents with Acute Ischemic Stroke. The SHINE Randomised Trial JAMA. 2019;322(4):326–335

Dr Sethi The Restrictive IV Fluid Trial in Severe Sepsis and Septic Shock (RIFTS): A Randomized Pilot Study Crit Care Med. 2019 Jul;47(7):951-959



30/7/19 Dr Grieve Association of Duration and Type of Surgical Prophylaxis With Antimicrobial-Associated Adverse Events. JAMA Surg. 2019;154(7):590–598.

23/7/19 Dr Raith Association Between State-Mandated Protocolized Sepsis Care and In-hospital Mortality Among Adults With Sepsis JAMA. 2019;322(3):240-250. doi:10.1001/jama.2019.9021

Dr Sethi Complications in internal jugular vs subclavian ultrasound-guided central venous catheterization: a comparative randomized trial Intensive Care Medicine July 2019

16/7/19 Dr Hayres Isopropyl alcohol nasal inhalation for nausea in the ED: A RCT Ann Emerg Med. 2016;68(1):1–9.e1. Epub 2015 Dec 8

Dr Asundi A multicentre trial of vena cava filters in severely injured patients NEJM July 7, 2019

9/7/19 Dr Sethi Effect of pressure support vs T-piece ventilation strategies during spontaneous breathing trials on successful extubation among patients receiving mechanical ventilation: A RCT JAMA JAMA. 2019;321(22):2175-2182

Dr Chapman CENSER: Early use of norepinephrine in septic shock resuscitation Am J Respir Crit Care Med. 2019 May 1;199(9):1097-1105

2/7/19 Drs Raith, Kar, McArthur

Registrar clinical audits

25/6/19 Dr McCrae High risk heparin protocol

18/6/19 Dr Ohja Candidaemia in critically ill immunocompromised patients: report of a retrospective multicentre cohort study Ann. Intensive Care 2019 9:62

Dr Grieve Under Pressure: Clinical case report – low pressure hydrocephalus

11/6/19 Dr Grewal IABP in cardiogenic shock IABP-SHOCK II NEJM October 4, 2012

Dr Sethi Contemporary guidelines for the use of IABP

Dr Asundi Prophylactic IABP Counterpulsation

4/6/19 Dr Wong SPICE III - Early sedation with dexmedetomidine in critically ill patients NEJM 2019; 380:2506-2517

Dr Gerlach Nationwide analysis of REBOA in civilian trauma JAMA Surgery March 20, 2019

28/5/19 Dr Kar ROSE – Early neuromuscular blockade in the acute respiratory distress syndrome NEJM 2019; 380:1997-2008

Dr Grewal Effect of procalcitonin-guided antibiotic treatment on clinical outcomes in intensive care patients with infection & sepsis patients: a patient-level meta-analysis of randomised trials Critical Care (2018) 22:191

21/5/19 Dr Asundi SUPERNOVA – Feasibility & safety of extracorporeal CO2 removal to enhance protective ventilation in acute respiratory distress syndrome



Intensive Care Med. 2019 May;45(5):592-600

14/5/19 Dr Kar Nintedanib plus sildenafil in patients with idiopathic pulmonary fibrosis NEJM 2018; 379:1722-1731

Dr Raith Immunotherapy in Cancer Combined Nivolimumab & Ipilimumab in melanoma metastatic to the brain NEJM 2018; 379:722-730 New drugs, new toxicities: severe side effects of modern targeted and immunotherapy of cancer and their management Critical Care (2017) 21:89

7/5/19 Tub’s Practice Presentations

30/4/19 Dr Wong Influenza: disease basics, vaccinations

Dr Grieve Effectiveness of neuraminidase inhibitors in reducing mortality in patients admitted to hospital with influenza A H1N1pdm09 virus infection: a meta-analysis of individual participant data Lancet Respir Med 2014;2: 395–404

Dr Asundi Effect of early oseltamivir treatment on mortality in critically ill patients Clinical Infectious Diseases, ciz101, https://doi.org/10.1093/cid/ciz101

23/4/19

16/4/19 Dr Janssen Timing of PCI in NSTEMI NEJM April 2019

Dr Kar Intermittent pneumatic compression devices for VTE prophylaxis NEJM April 2019

2/4/19 Dr Grieve Euglycaemic DKA related to SGLT2 inhibitors

Dr Gerlach Central lines infections

26/3/19 Dr Hayres TAVI in low risk patients NEJM March 2019

Dr Asundi TAVI for AS in patients who cannot undergo surgery NEJM October 2010

Dr Young Non-inferiority trials

12/3/19 Dr Chapman IOTA trial – liberal vs conservative O2 therapy a meta-analysis and systematic review Lancet April 2018

Dr Gerlach 7 vs 14 days for uncomplicated GN bacteraemia Journal of Clinical Infectious Disease; 2018

5/3/19 Dr Asundi SPLIT trial – Effect of buffered crystalloid vs saline on AKI in ICU patients JAMA October 2015

Dr Wong Long term outcome of patients with haematological malignancy & multi-organ failure admitted to ICU Critical Care Med. February 2019

26/2/19 Dr Sethi IRIS Trial - Effect of cricoid pressure vs sham procedure



JAMA January 2019

Dr Collett Bag mask ventilation during tracheal intubation of critically ill adults NEJM February 2019

19/2/19 NO JC

12/2/19 NO JC

5/2/19 NO JC

29/1/19 Dr Grieve Inhaled tranexamic acid for haemoptysis CHEST December 2018

Dr Asundi NUTRIREA-2 trial – Enteral vs parenteral early nutrition in ventilated patients with shock Lancet January 2018

Dr Sethi Calibrated cardiac output monitoring vs standard care for fluid management in the shocked ICU patient. Journal of Intensive Care January 2019

22/1/19 Lecture on clinical coding

15/1/19 Dr Webber Catheter ablation of atrial fibrillation in patients with heart failure Annals of Internal Medicine; vol. 170, no. 1; 1 Jan 2019

STERNOCAT – The effect of local anaesthetic continuous wound infusion for the prevention of post-operative pneumonia after on-pump cardiac surgery with sternotomy. Intensive Care Medicine; January 2019, Volume 45, Issue 1, pp 33–43

8/1/19 Dr Kar VERDICT - Early vs standard care invasive examination and treatment of patients with non-ST-segment elevation acute coronary syndrome Circulation 28 Aug 2018;138:2741–2750

Dr Bart Porphyria NEJM August 31 2017, 337:9

Dr Asundi Early enteral nutrition reduces mortality and improves other key outcomes in patients with major burn injury: a meta-analysis of randomised control led trials Critical Care Medicine December 2018; 46(12)

1/1/19 NO JC

25/12/18 NO JC

18/12/18 NO JC

11/12/18 Dr Neuts Nebulised anticoagulants in lung injury in critically ill patients – an updated systematic review of preclinical and clinical studies Ann Transl Med 2017; 5(22):444 Nebulised heparin for patients under mechanical ventilation: an individual patient data meta-analysis Ann Intensive Care 2016; 6:33

Dr Ohja Handovers among staff intensivists: a study of information loss and clinical accuracy to anticipate events Critical Care Medicine November 2018, vol 46, number 11



Dr Janssen PReVENT – Effect of low vs intermediate tidal volume strategy on ventilator-free days in intensive care unit patients without ARDS JAMA 2018;320(18):1872-1880

4/12/18 Dr Grieve IABP SHOCK II – initial trial, 1 & 6 year follow up Intra-aortic Balloon Support for Myocardial Infarction with Cardiogenic Shock NEJM October 4th 2012, vol 367, no 14 Intra-aortic balloon counter-pulsation for myocardial infarction complicated by cardiogenic shock (IABP-SHOCK II): final 12 month results of a randomised, open label trial. Lancet 2013; 382; 1638-45 Intra-aortic Balloon Pump in Cardiogenic Shock Complicating Acute Myocardial Infarction: Long-term 6 year outcome of the randomised IABP-SHOCK II trial Circulation 2018; 139; 00-00

Dr Gerlach Effect of thiamine administration on lactate clearance and mortality in patients with septic shock. Journal of Critical Care Medicine November 2018, Vol 46, #11

27/11/18 Prof Greenwood Advances in Burns Care

20/11/18 Dr Grieve

Acute on Chronic Liver Failure: Getting Ready for Prime Time Hepatology vol. 68, no. 4, 2018 Acute on Chronic Liver Failure: A new syndrome that will reclassify cirrhosis Journal of Hepatology, 2015, vol.62

Dr Kar Validation of CLIF-C ACLF score to define a threshold for futility of intensive care support for patients with acute-on-chronic liver failure Critical Care (2018) 22:254

13/11/18 Dr Wong Haloperidol and Ziprasidone for Treatment of Delirium in Critical Illness NEJM October 22, 2018

6/11/18 Dr Rajendran HIGH. Effect of High-Flow Nasal Oxygen vs Standard Oxygen on 28-Day Mortality in Immunocompromised Patients With Acute Respiratory Failure. JAMA October 24th 2018



Dr Hayres SWIPE. Small volume resuscitation with albumin in intensive care. Intensive Care Medicine October 21st 2018

30/10/18 Dr Gerlach SUP-ICU. Pantoprazole in Patients at Risk for Gastrointestinal Bleeding in the ICU. NEJM October 24th 2018

Dr Bart TARGET. Energy-Dense versus Routine Enteral Nutrition in the Critically Ill. NEJM October 25th 2018

Dr Heytens POLAR. Effect of Early Sustained Prophylactic Hypothermia on Neurologic Outcomes Among Patients With Severe Traumatic Brain Injury. JAMA October 24th

23/10/18 Dr Sethi Rate control versus rhythm control for atrial fibrillation after cardiac surgery. NEJM May 19 2016

Dr Neuts Review of therapeutic hypothermia in ICU TTM. Targeted temperature management at 33C versus 36C after cardiac arrest. NEJM December 5th 2013 Targeted temperature management in the ICU: guidelines from a French expert panel. Ann. Intensive Care 2017

16/10/18 Dr Bart Early vs late initiation of renal replacement therapy in patients with acute kidney injury – a systematic review & meta-analysis of randomised controlled trials BMC Nephrology 2017 18:78

Dr Grieve IDEAL-ICU. Timing of renal replacement therapy in patients with acute kidney injury & sepsis. NEJM October 2018; 379:1431-42

9/10/18 Dr Anderson Rescue therapies for oxygenation in ARDS

Dr Ohja Outcomes from Grade 5 SAH

Dr Bart Pulmonary tests to predict outcome post cardiac surgery

2/10/18 Dr Grieve Fluid volume, fluid balance and patient outcome in severe sepsis and septic shock: A systematic review Journal of Critical Care 48 (2018) 153–159



Dr Asundi Effectiveness of antiarrhythmic drugs for shockable cardiac arrest: A systematic review Resuscitation 132(2018) 63-72

Dr Lee Six-Month Outcomes after Restrictive or Liberal Transfusion for Cardiac Surgery NEJM, August 26, 2018

25/9/18 Dr Kar Aspirin Extravaganza: - Clopidogrel and aspirin in acute ischaemic stroke and high-risk TIA. NEJM July 19, 2018; 379(3) Effect of aspirin for primary prevention in persons with diabetes mellitus NEJM August 2018 Effect of aspirin on all-cause mortality in the healthy elderly NEJM September 2018 Effect of aspirin on disability-free survival in the healthy elderly NEJM September 2018 Effect of aspirin on cardiovascular events and bleeding in the healthy elderly NEJM September 2018

Dr Ohja The association of clinical frailty with outcomes of patients reviewed by rapid response teams: an international prospective observational cohort study Critical Care 2018, 22:227

18/9/18 Dr Webber Association of vasopressin plus catecholamine vasopressors vs catecholamines alone with atrial fibrillation in patients with distributive shock. A systematic review and meta-analysis. JAMA 2018; 319(18)

Dr Bart Effect of pipercillin-tazobactam vs meropenem on 30 day mortality mortality for patients with E. coli or Klebsiella pneumoniae bloodstream infection and ceftriaxone resistance. A randomised clinical trial. JAMA 2018; 320(10)

Dr Janssen Hydrocortisone, vitamin C and thiamine for the treatment of severe sepsis and septic shock. A retrospective before-after study. Chest June 2017; 151(6)

11/9/18 Dr Grieve Review of evidence for prone positioning in ARDS: -



Effect of prone positioning on the survival of patients with acute respiratory failure. NEJM 2001 Aug 23;345(8):568-73 Prone Positioning in Severe Acute Respiratory Distress Syndrome (PROSEVA). NEJM 2013 June 6; 368; 2159-68

Prone positioning reduces mortality from acute respiratory distress syndrome in the low tidal volume era: a meta-analysis. Intensive Care Med. 2014 Mar;40(3):332-41.

Dr Neuts Vasopressin versus Norepinephrine in Patients with Vasoplegic Shock after Cardiac Surgery: The VANCS Randomized Controlled Trial. Anesthesiology 1 2017, Vol.126, 85-93

Dr Hayes Faecal transplant in ICU Diagnosis & Treatment of Clostridium Difficile Infection JAMA 2018, 320(10) The Use of Faecal Microbiota Transplant as Treatment for Recurrent or Refractory Clostridium Difficile Infection and Other Potential Indications Journal of Hospital Infection, vol 100, supplement 1

4/9/18 Dr Janssen Procalcitonin in ICU Debate - Pro

Dr Bart Procalcitonin in ICU Debate - Con

28/8/18 Dr Petrilli Project presentation – Team time out & checklists

21/8/18 Dr Atterton

The Durability of Endovascular Coiling Versus Neurosurgical Clipping of Ruptured Cerebral Aneurysms: 18 year Follow-Up of the UK Cohort of the International Subarachnoid Aneurysm Trial (ISAT) Lancet 2015; 385: 691-697

Dr Bart

International Subarachnoid Aneurysm Trial – ISAT Part II: Study Protocol for a Randomized Controlled Trial Trials 2013; 14: 156

Dr Gerlach

International Subarachnoid Aneurysm Trial (ISAT) of Neurosurgical Clipping versus Endovascular Coiling in 2143 Patients with Ruptured Intracranial Aneurysms: A Randomized Trial Lancet 2002; 360: 1267-1274

14/8/18 Dr Grieve Critically Ill Allogenic HSCT Patients in the Intensive Care Unit: A Systematic Review and Meta-analysis of Prognostic Factors of Mortality



Bone Marrow Transplantation April 2018; Published online first.

Dr Neuts Clinical Predictors of Survival and Functional Outcome of Stroke Patients Admitted to the Critical Care Critical Care Medicine 2018; 46(7): 1085-1092

7/8/18 Dr Young and Dr Wong

A Brief Update and Refresher on Ebola

31/7/18 Dr Kar Mortality and Morbidity in Acutely Ill Adults Treated with Liberal Versus Conservative Oxygen Therapy (IOTA): A Systematic Review and Meta-analysis Lancet 2018; 391: 1693-1705

Dr Sethi Prehospital Plasma during Air Medical Transport in Trauma Patients for Hemorrhagic Shock NEJM 2018; 379: 315-326

24/7/18 Dr Bart Beta-Blockers in COPD A Cohort Study from the TONADO Research Program CHEST 2018; 153(6): 1315-1325

Dr Wong A Randomized Trial of Epinephrine in Out-of-Hospital Cardiac Arrest NEJM July 2018; Published online first.

17/7/18 Dr Heytens Association of Inferior Vena Cava Filter Placement for Venous Thromboembolic Disease and a Contraindication to Anticoagulation With 30-Day Mortality JAMA Network Open 2018; 1(3)

Dr Vanbiervliet Association of Anti–FactorXa–Guided Dosing of Enoxaparin With Venous Thromboembolism After Trauma JAMA Surgery 2018; 153(2): 144-149

10/7/18 Dr Bart Cytomegalovirus Infection and Outcome in Immune-competent Patients in the Intensive Care Unit: A Systematic Review and Meta-analysis BMC Infectious Diseases 2018; 18:289

Dr Neuts Epinephrine Versus Norepinephrine for Cardiogenic Shock After Acute Myocardial Infarction Journal of The American College of Cardiology 2018; 72(2): 173-182

3/7/18 Dr Sethi Predictive Value of Serum Albumin Levels on Noradrenaline and Fluid Requirements in the First 24h after Admission to the Intensive Care Unit: A Prospective Observational Study Journal of Critical Care 2018; 47: 99-103



26/6/18 Dr Grieve

Sodium Bicarbonate Therapy for Patients with Severe Metabolic Acidaemia in the Intensive Care Unit (BICAR-ICU): A Multicentre, Open-label, Randomised, Controlled, Phase 3 Trial. Lancet June 2018; Published online first.

Dr Raith

Vascularised Pancreas Transplant Protocol for Royal Adelaide Hospital

Dr Wong

Is Routine Chest X-ray After Ultrasound-Guided Central Venous Catheter Insertion Choosing Wisely? A Population Based Retrospective Study of 6875 Patients Chest March 2018; Published online first.

19/6/18 Invited Speaker: Prof Ludbrook

Advanced Recovery Project

Invited Speaker: Dr McRae

Heparin Induced Thrombocytopaenia

12/6/18 Dr Asundi

Feasibility and Safety of Low-Flow Extracorporeal CO2 Removal Managed with a Renal Replacement Platform to Enhance Lung-Protective Ventilation of Patients with Mild-to-moderate ARDS Critical Care 2018; 22: 122

Dr Yeo

Effect of a Perioperative Intra-Aortic Balloon Pump in High-Risk Cardiac Surgery Patients: A Randomized Clinical Trial Critical Care Medicine April 2018; Published online first.

5/6/18 Dr Kar

A Randomized Trial of a Family-Support Intervention in Intensive Care Units NEJM February 2018; Published online first.

Dr Heytens

Hospital End-of-life Care in Haematological Emergencies BMJ Supportive and Palliative Care 2018; Published online first.

Dr Raith

Audit of Malignancy in ICU

29/5/18 Invited Speaker: Dr Tom Painter

Restrictive versus Liberal Fluid Therapy for Major Abdominal Surgery NEJM May 2018; Published online first.

Dr Bart Efficacy and Economic Assessment of Conventional Ventilatory versus Extracorporeal Membrane Oxygenation for Severe Adult Respiratory Failure (CESAR): A Multicentre Randomized Controlled Trial. Lancet 2009; 374(9698): 1351-1363



Dr Wong Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome NEJM 2018; 378(21): 1965-1975

22/5/18 Dr Sundararajan

Mortality and morbidity literature review

Dr Yeo

Pilot Study on Feasibility of Intensive Care Unit Bereavement Follow-up Service

15/5/18 Dr Grieve

Tenecteplase versus Alteplase before Thrombectomy for Ischemic Stroke NEJM 2018; 378(17): 1573-1582

Dr Salamon

Restrictive versus Liberal Fluid Therapy for Major Abdominal Surgery NEJM May 2018; Published online first.

8/5/18 ICU Orientation

1/5/18 Dr Heytens

2017 European Society of Cardiology Focused Update on Dual Anti-platelet Therapy in Coronary Artery Disease Developed in Collaboration with European Association for Cardio-Thoracic Surgery European Heart Journal 2018; 39(3): 213-260

Dr Vanvierbliet

Effect of Ticagrelor Plus Aspirin, Ticagrelor Alone, or Aspirin Alone on Saphenous Vein Graft Patency 1 Year After Coronary Artery Bypass Grafting: A randomized Clinical Trial JAMA 2081; 319(16): 1677-1686

24/4/18 Dr Bart

Extra-corporeal Membrane Oxygenations for Refractory Cardiogenic Shock After Adult Cardiac Surgery: A Systematic Review and Meta-analysis Journal of Cardiothoracic Surgery 2017; 12(1): 55

Dr Salamon

Stress Ulcer Prophylaxis in Intensive Care Unit Patients Receiving Enteral Nutrition: A Systematic Review and Meta-analysis Critical Care 2018; 22(1): 20

17/4/18 Dr Grieve

Induced Hypertension for Delayed Cerebral Ischaemia in Subarachnoid Haemorrhage Stroke 2018; 49(1): 76-83

Dr Wong

Declining Mortality in Critically Ill Patients with Cirrhosis in Australia and New Zealand Between 2000 and 2015 Journal of Hepatology 2017; 67(6): 1185-1193

10/4/18 Dr Bart

A Comparative Analysis of Sepsis Identification Methods in an Electronic Database



Critical Care Medicine 2018; 46(4): 494-499

Dr Kar

Low-dose Nocturnal Dexmedetomidine Prevents ICU Delirium: A Randomized, Placebo-controlled Trial American Journal of Respiratory and Critical Care Medicine April 2018; Published online first.

3/4/18 Dr Wong Effect of Bag-Mask Ventilation vs Endotracheal Intubation During Cardiopulmonary Resuscitation on Neurological Outcome After Out-of-Hospital Cardiorespiratory Arrest JAMA 2018; 319(8): 779-787

Dr Yeo Effect of Systematic Intensive Care Unit Triage on Long-term Mortality Among Critically Ill Elderly Patients in France: A Randomized Clinical Trial JAMA 2017; 318(15): 1450-1459

27/3 /18 EPAS Training

20/3 /18 Dr Wong

Catheter Ablation for Atrial Fibrillation with Heart Failure NEJM 2018; 378: 417-427

Dr Yeo 6-month versus 12-month or Longer Dual Antiplatelet Therapy After Percutaneous Coronary Intervention in Patients with Acute Coronary Syndrome (SMART-DATE): A Randomised, Open-label, non-inferiority Trial The Lancet March 2018; Published online first.

12/3/18 Dr Flabouris

Effect of a Pediatric Early Warning System on All-Cause Mortality in Hospitalized Pediatric Patients The EPOCH Randomized Clinical Trial JAMA February 2018; Published online first.

Dr Neuts

Prognostic Value of MRI in Moderate and Severe Traumatic Brain Injury: A Systematic Review and Meta-Analysis Critical Care Medicine 2017; 456(12): 1280-1288

6/3/18 Dr Asundi

Balanced Crystalloids versus Saline in Critically Ill Adults NEJM 2018; 378: 829-839

Dr Bart

Balanced Crystalloids versus Saline in Noncritically Ill Adults NEJM 2018; 378: 819-828

Dr Salamon

Hydrocortisone Plus Fludrocortisone for Adults with Septic Shock NEJM 2018; 378: 809-818

27/2/18 Dr Heytens

Thrombectomy for Stroke at 6 to 16 Hours with Selection by Perfusion Imaging NEJM 2018; 378: 708-718



Dr Sethi Review of Current Evidence on Decompressive Craniectomy following Malignant MCA Infarct.

20/2/18 Dr Millar

Audit on Targeted Temperature Management Following Out of Hospital Cardiac Arrest in Patients Admitted to the Royal Adelaide Hospital Intensive Care Unit.

Dr Yeo

Adjunctive Corticosteroid Therapy in Patients with Septic Shock NEJM January 2018; Published online first.

13/2/18 Dr Reddi

Routine CT Scanning of Patients Retrieved to a Tertiary Referral Centre on Veno-Venous Extracorporeal Membrane Oxygenation: How Frequently Does it Change Therapy and Observed Adverse Events

Dr Raith

How to Perform an Audit

6/2/18 ICU Orientation

30/1/18 No Journal Club

23/1/18 Dr Stewart and Dr Yeo

Royal Adelaide Hospital ICU Bereavement Follow-up Project Introductory Talk




26/12/17

No Journal Club

19/12/17

No Journal Club

12/12/17 Guest Speaker: Dr Painter

Restrictive or Liberal Red-Cell Transfusion for Cardiac Surgery NEJM November 2017; Published online first.

Dr Sethi A Multicenter, Randomized, Controlled Clinical Trial of Transfusion Requirements in Critical Care NEJM 1999; 340(6): 409-417

Dr Yeo Liberal or Restrictive Transfusion after Cardiac Surgery NEJM 2015; 372(11): 997-1008

5/12/17 Dr Vanbiervliet Guidelines for the Diagnosis and Management of Critical Illness-Related Corticosteroid Insufficiency (CIRCI) in Critically Ill Patients (Part I): Society of Critical Care Medicine (SCCM)



and European Society of Intensive Care Medicine (ESCIM) 2017 Critical Care Medicine 2017; 45(12): 2070-2088

Dr Rajendran Predictors of Intubation in Patients with Acute Hypoxemic Respiratory Failure Treated with a Noninvasive Oxygenation Strategy Critical Care Medicine November 2017; Published online first.

28/11/17 BASIC Course

21/11/17 Dr Janssen Randomized, Multicentre Trial of Lateral Trendelenburg versus Semirecumbent Body Position for the Prevention of Ventilator-Associated Pneumonia Intensive Care Medicine 2017; 43: 1572-1584

Dr Sethi The Timing of Early Antibiotics and Hospital Mortality in Sepsis American Journal of Respiratory and Critical Care Medicine 2017; 196: 856-863

14/11/17 South Australia Trainee Lecture Series

7/11/17 Dr Sethi

The European Society for Clinical Nutrition and Metabolism Guidelines for Adult Parenteral Nutrition

Dr Rajendran

American Society for Parenteral and Enteral Nutrition Guidelines for Use of Parenteral Nutrition in Adult Patients

Dr Kar The Royal Adelaide Hospital Total Parenteral Nutrition Protocol and Current Evidence

31/10/17 Dr Davies

Efficacy and Economic Assessment of Conventional Ventilatory versus Extracorporeal Membrane Oxygenation for Severe Adult Respiratory Failure (CESAR): A Multicentre Randomized Controlled Trial. Lancet 2009; 374(9698): 1351-1363

Dr Asundi

Do We Need Randomized Clinical Trials in Extracorporeal Respiratory Support?

24/10/17 Dr Gowen Higher vs Lower Positive End-Expiratory Pressure in Patients with Acute Lung Injury and Acute Respiratory Distress Syndrome: A Systematic Review and Meta-analysis JAMA 2010; 303(9): 865-873

Dr Guido Effect of Lung Recruitment and Titrated Positive End-Expiratory Pressure (PEEP) vs Low PEEP on Mortality in Patients With Acute Respiratory Distress Syndrome: A Randomized Clinical Trial JAMA 2017; 318(14): 1335-1346



17/10/17 Dr Grieve

Reconnection to Mechanical Ventilation for 1 Hour After a Successful Spontaneous Breathing Trial Reduces Reintubation in Critically Ill Patients: A Multicenter Randomized Controlled Trial Intensive Care Medicine 2017; 43(11): 1660-1667

Dr Raith

Age of Red Cells for Transfusion and Outcomes in Critically Ill Adults NEJM 2017; 377: 1858-1867

10/10/17 Dr Gowen Does a Balanced Transfusion Ratio of Plasma to Packed Red Blood Cells Improve Outcomes in Both Trauma and Surgical Patients? A Meta-analysis of Randomized Controlled Trials and Observational Studies American Journal of Surgery September 2017; Published online first.

Dr Kar

Bacterial Colonization and Succession in a Newly Opened Hospital Science Translational Medicine 2017; 9(391): 1-11

3/10/17 ANZICS Intensive Care ASM Presentations

26/9/17 Guest Speaker: Dr Bhattacharjya

Pancreatic Transplantation

19/9/17

Dr Janssen Single versus Serial Measurements of Neuron-Specific Enolase and Prediction of Poor Neurological Outcome in Persistently Unconscious Patients after Out-of-Hospital Cardiac Arrest- A TTM Trial Substudy PLoS ONE January 2017

15/8/17 Dr Flabouris New RAH Education Session

8/8/17 Guest Speaker: Dr Jorge Brieva

DCD 10-10 Pilot Study: Validation of a 10 Minute Spontaneous Breathing Trial To Predict Time To Circulatory Death in Organ Donation Candidates

Dr Badek

Prediction of Death After Withdrawal of Life-sustaining Treatments Critical Care and Resuscitation 2008; 10: 278-284

1/8/17 Dr Salamon The Effect of ARDS on Survival: Do Patients Die From ARDS or With ARDS? Journal of Intensive Care Medicine July 2017; Published online first.



25/7/17 Dr Badek Critical Care Admission Following Elective Surgery Was Not Associated With Survival Benefit: Prospective Analysis of Data From 27 Countries Intensive Care Medicine 2017; 43(7): 971-979

Dr White Effects of Restricting Perioperative Use of Intravenous Chloride on Kidney Injury in Patients Undergoing Cardiac Surgery: The LICRA Pragmatic Controlled Clinical Trial Intensive Care Medicine 2017; 43: 795-806

Dr Yeo Effect of a Buffered Crystalloid Solution vs Saline on Acute Kidney Injury Among Patients in the Intensive Care Unit The SPLIT Randomized Clinical Trial JAMA 2015; 314(16): 1701-1710

18/7/17 Dr Asundi

Continuous Renal Replacement Therapy Versus Intermittent Hemodialysis in Intensive Care Patients: Impact on Mortality and Renal Recovery Intensive Care Medicine 2016; 42: 1408-1417

Dr Davies Discriminative Accuracy of Physician and Nurse Predictions for Survival and Functional Outcomes 6 Months After an ICU Admission JAMA 2017; 317(21): 2187-2195

Dr Evans How Do Clinicians Prepare Family Members for the Role of Surrogate Decision-Maker? Journal of Medical Ethics July 2017. Published online first.

Dr Sethi Acute Kidney Injury as a Risk Factor for Delirium and Coma during Critical Illness American Journal of Respiratory and Critical Care Medicine 2017; 195(12): 1597-1607

11/7/17 Dr Badek

Dexmedetomidine for Prevention of Delirium in Elderly Patients After Non-Cardiac Surgery: A Randomized, Double-Blind, Placebo-Controlled Trial Lancet 2016; 388(10054): 1893-1921

Dr Yeo

Impact of Dexmedetomidine on the Incidence of Delirium in Elderly Patients after Cardiac Surgery: A Randomized Controlled Trial PLoS ONE February 2017

4/7/17 Dr Davies Drug Safety Committee Update

Dr Janssen Early, Goal-Directed Mobilisation in the Surgical Intensive Care Unit: A Randomized Controlled Trial Lancet 2016; 388(10052): 1377-1388



Dr Sethi Levosimendan for Hemodynamic Support after Cardiac Surgery NEJM 2017; 376: 2021-2031

27/6/17 Dr Salamon Angiotensin II for Treatment of Vasodilatory Shock NEJM March 2017. Published online first.

Dr Yeo The Beta-Agonist Lung Injury Trial (BALTI) American Journal of Respiratory and Critical Care Medicine 2006; 173: 281-287 Beta-Agonist Lung Injury Trial-2 (BALTI-2): A Multicentre, Randomised, Double-blind, Placebo-controlled Trial and Economic Evaluation of Intravenous Infusion of Salbutamol versus Placebo in Patients with Acute Respiratory Distress Syndrome Health Technology Assessment 2013; 17(13): 1-61

20/6/17 Dr Davies

Narcotic and Benzodiazepine Use After Withdrawal of Life Support: Association With Time of Death? Chest 2004; 126(1): 286-293

Dr Janssen

The Infusion of Opioids During Terminal Withdrawal of Mechanical Ventilation in the Medical Intensive Care Unit Journal of Pain and Symptom Management 2011; 42(1): 44-51

13/6/17 Dr Bart

Renal Recovery After Acute Kidney Injury Intensive Care Medicine 2017; 43(6): 855-866

Dr Yeo

Initiation Strategies for Renal-Replacement Therapy in the Intensive Care Unit NEJM 2016; 375(2): 122-133


30/5/17 Dr Salamon Decompressive Craniectomy in Embolic Stroke

Dr Yeo Decompressive Craniectomy in Traumatic Brain Injury

23/5/17 Dr Bart

Fifty Years of Research in ARDS

Dr Sundararajan

Ventilation in ARDS: Can we personalise treatment in the era of patient centred care?

16/5/17 Tub ANZICS/CICM Presentations

9/5/17

Dr Janssen and Dr Sethi

Debate on: “Furosemide Should be Administered Freely In ICU Patients”

2/5/17 Dr Bart Review of Evidence on Daily Sedation Interruption



Dr Yeo

Effect of Dexmedetomidine on Mortality and Ventilator-Free Days in Patients Requiring Mechanical Ventilation with Sepsis. A Randomized Clinical Trial JAMA 2017; 317(13): 1321-1328

18/4/17 Dr Badek and Dr Yeo

Debate on: “The Role of Thrombolysis in Submassive Pulmonary Embolism”

11/4/17 Dr Bart

Surgical or Transcatheter Aortic-Valve Replacement in Intermediate-Risk Patients NEJM 2017; 376: 1321-1331

Dr Sethi

Two-Year Outcome after Endovascular Treatment for Acute Ischemic Stroke NEJM 2017; 376: 1341-1349

4/4/17 Dr Badek Levosimendan in Patients with Left Ventricular Dysfunction Undergoing Cardiac Surgery NEJM Mach 2017. Published online first.

Dr Raith Prognostic Accuracy of the SOFA Score, SIRS Criteria, and qSOFA Score for In-Hospital Mortality Among Adults With Suspected Infection Admitted to the Intensive Care Unit JAMA 2017; 317(3): 290-300

28/3/17

Infection Control Update

Dr Davies

Review of Steroid in Sepsis and Septic Shock

21/3/17

ICU Research Update

14/3/17 Dr Janssen

Normocaloric Versus Hypocaloric Feeding on the Outcome of ICU Patients: A Systematic Review and Meta-Analysis Intensive Care Medicine 2016; 42: 316-323

Dr Sethi Permissive Underfeeding or Standard Enteral Feeding in High- and Low-Nutritional-Risk Critically Ill Adults. Post Hoc Analysis of the PermiT Trial American Journal of Respiratory and Critical Care Medicine 2017; 195(5): 652-662

7/3/17 Dr Badek

Airway Management Outside the Operating Room: How to Better Prepare Canadian Journal of Anaesthesia February 2017. Published online first.

Dr Yeo

Anti-N-Methyl-D-Aspartate Receptor Encephalitis in Adult Patients Requiring Intensive Care



American Journal of Respiratory and Critical Care Medicine 2017; 195(4): 491-499

28/2/17 Dr Sethi

Readmissions to Intensive Care: A Prospective Multicentre Study in Australia and New Zealand Critical Care Medicine 2017; 45(2): 290-297

21/2/17 Dr Asundi Conservative Fluid Management or Deresuscitation for Patients with Sepsis or Acute Respiratory Distress Syndrome Following the Resuscitation Phase of Critical Illness: A Systematic Review and Meta-analysis Intensive Care Medicine 2017; 43: 155-170

Dr Tamblyn ARDS and the Grand Unifying Theory of Hypoxaemia



31/1/17 Dr Asundi Dr Badek Dr Davies

Surviving Sepsis Campaign Updates Guidelines for Management of Sepsis and Septic Shock Intensive Care Medicine January 2017. Published online first.

24/1/17 Dr Bart Percutaneous Mechanical Circulatory Support Versus Intra-Aortic Balloon Pump in Cardiogenic Shock After Acute Myocardial infarction Journal of The American College of Cardiology 2017; 69(3): 278-287

Dr Yeo Thrombolytic Removal of Intraventricular Haemorrhage in Treatment of Severe Stroke: Results of the Randomised, Multicentre, Multiregion, Placebo-Controlled CLEAR III Trial The Lancet January 2017. Published online first.


10/1/17 Dr Abraham Employment Outcomes After Critical Illness: An Analysis of the Bringing to Light the Risk Factors and Incidence of Neuropsychological Dysfunction in ICU Survivors Cohort Critical Care Medicine 2016; 44(11): 2003-2009

Dr Yeo Hypothermia for Neuroprotection in Convulsive Status Epilepticus NEJM 2016; 375: 2457-2567

20/12/16 Dr Davies Platelet Transfusion versus Standard Care After Acute Stroke Due to Spontaneous Cerebral Haemorrhage Associated with Antiplatelet Therapy (PATCH): A Randomised, Open-Label, Phase 3 Trial The Lancet 2016; 387(10038): 2605-2613



Dr Parasuraman Effect of Hydrocortisone on Development of Shock Among Patients with Severe Sepsis: The HYPRESS Randomized Clinical Trial JAMA 2016; 316(17): 1775-17785

13/12/16 Dr Bart Nebulized Antibiotics for Ventilator-associated Pneumonia: A Systematic Review and Meta-analysis Critical Care 2015; 19: 150

Dr Yeo Prevention of Bleeding in Patients with Atrial Fibrillation undergoing PCI NEJM November 2016; Published online first.

6/12/16 Dr Davies Current Guidelines and Recommendations on Prognostication Post Cardiac Arrest

Dr Wong Reducing the Hospital Burden of Heparin-Induced Thrombocytopenia: Impact of an Avoid-Heparin Program Blood 2016; 127(16): 1954-9

29/11/16 Guest Speaker: Dr Painter

Tranexamic Acid in Patients Undergoing Coronary-Artery Surgery NEJM October 2016; Published online first.

Dr Bart Five-Year Outcomes after Off-Pump or On-Pump Coronary-Artery Bypass Grafting NEJM October 2016; Published online first.

Dr Yeo Long-term Outcomes in Patients with Septic Shock Transfused at a Lower versus a Higher Haemoglobin Threshold: the TRISS Randomised, Multicentre Clinical Trial Intensive Care Medicine 2016; 42: 1685-1694

22/11/16 Dr Davies Pro: Accuracy and Utility of the PA Catheter in the Modern ICU

Dr Singh Con: Accuracy and Utility of the PA Catheter in the Modern ICU

15/11/16 Dr Abraham Age of Transfused Blood in Critically Ill Adults NEJM 2015; 372: 1410-1418

Dr Bart Towards a National Model for Organ Donation Requests in Australia: Evaluation of a Pilot Model Critical Care and Resuscitation 2015; 17(4): 233-238

Dr Yeo Effect of Short-Term versus Long-Term Blood Storage on Mortality after Transfusion. Informing Fresh versus Old Red Cell Management (INFORM) Trial. NEJM October 2016; Published online first.



1/11/16 Dr Tamblyn A Brief History on Sepsis

Dr Yeo Beta-Lactam Infusion in Severe Sepsis (BLISS): A Prospective, Two-centre, Open-labelled Randomised Controlled Trial of Continuous versus Intermittent Beta-lactam Infusion in Critically Ill Patients with Severe Sepsis Critical Care Medicine 2016; 42: 1535-1545

25/10/16 Dr Asundi Glycemic Control, Mortality and Hypoglycemia in Critically Ill Patients: A Systematic Review and Network Meta-analysis of Randomzied Controlled Trials Critical Care Medicine September 2016; Published online first.

Dr Singh

The Optimal Target for Acute Glycemic Control in Critically Ill Patients: A Network Meta-analysis Critical Care Medicine September 2016; Published online first.

Dr Wong

Demystifying Trial Networks and Network Meta-analysis BMJ 2013; 346: f2914

18/10/16 Dr Abraham Effect of Conservative vs Conventional Oxygen Therapy on Mortality Among Patients in an Intensive Care Unit. The Oxygen-ICU Randomized Clinical Trial JAMA October 2016; Published online first.

Dr Bart Levosimendan for the Prevention of Acute Organ Dysfunction in Sepsis NEJM October 2016; Published online first.

Dr Yeo Intravenous Iron or Placebo for Anaemia in Intensive Care: The IRONMAN Multicentre Randomized Blinded Trial. A Randomized Trial of IV Iron in Critical Illness Intensive Care Medicine September 2016; Published online first.

11/10/16 ANZICS ASM Oral Presentation Practice

4/10/16 Guest Speaker: Dr Simon McRae

Critical Bleeding and the Role of The New Oral Anticoagulants

Dr Abraham Idaruxizumab for Dabigatran Reversal NEJM 2015; 373(6): 511-520

Dr Bart Andexanet Alpha for Acute Major Bleeding Associated with Factor Xa Inhibitors NEJM 2016; 375: 1131-11141



27/9/16 Guest Speaker: Dr Emily Meyer

A Proposed Study of Cortisol-Binding Globulin in Septic ICU Patients

Dr Asundi

Mechanical Thrombectomy after Intravenous Alteplase versus Alterplase Alone after Stroke (THRACE): A Randomized Controlled Trial Lancet Neurology 2016; 15: 1138-1147

20/9/16 Dr Abraham Literature Review of Decompressive Craniectomy in Head injury

Dr Yeo Trial of Decompressive Craniectomy for Traumatic Intracranial Hypertension NEJM September 2016; Published online first.

13/9/16 Guest Speaker: Dr Emily Meyer

A Proposed Study of Cortisol-Binding Globulin in Septic ICU Patients

Dr Wong Long-Term Quality of Life Among Survivors of Severe Sepsis: Analysis of Two International Trials Critical Care Medicine 2016; 44(8): 1462-1467

6/9/16 Dr Bart The RECOVER Program: Disability Risk Groups and One Year Outcome After ≥ 7 Days of Mechanical Ventilation American Journal of Respiratory Critical Care Medicine March 2016; Published online first.

Dr Yeo Higher versus Lower Blood Pressure Targets for Vasopressor Therapy in Shock: A Multicentre Pilot Randomized Controlled Trial Intensive Care Medicine 2016; 42: 542-550

30/8/16 Dr Davies Intensive Care Unit Experience of Haemopoietic Stem Cell Transplant Patients Internal Medicine Journal 2012; 42(7): 748-754

Dr Parasuraman Effect of Noninvasive Ventilation Delivered by Helmet versus Face Mask on the Rate of Endotracheal Intubation in Patients with Acute Respiratory Distress Syndrome A Randomized Clinical Trial JAMA 2016; 315(22): 2435-2441

23/8/16 Dr Bart Vasopressin versus Norepinephrine Infusion in Patients with Septic Shock NEJM 2008; 358(9): 877-887

Dr Yeo Effect of Early Vasopressin vs Norepinephrine on Kidney Failure in Patients With Septic Shock JAMA 2016; 316(5): 509-518



9/8/16 Dr Edwards Long-Term Quality of Life Among Survivors of Severe Sepsis: Analyses of Two International Trials Critical Care Medicine 2016; 44(8): 1461-1467

Dr Abraham The Feasibility and Safety of Extracorporeal Carbon Dioxide Removal to Avoid Intubation in Patients with COPD Unresponsive to Noninvasive Ventilation for Acute Hypercapnic Respiratory Failure (ECLAIR study):Multicentre Case-Control Study Intensive Care Medicine July 2016; Published online first.

Dr Yeo Safety and Feasibility of Low-flow Extracorporeal Carbon Dioxide Removal to Facilitate Ultra-Protective Ventilation in Patients with Moderate ARDS. Critical Care 2016; 20: 36

2/8/16 Dr Asundi Prone Positioning in Severe Acute Respiratory Distress Syndrome NEJM 2016; 368(23): 2159-2168 Neuromuscular Blockers in Early Acute Respiratory Distress Syndrome NEJM 2010; 363(12): 1107-1116

Dr Parasuraman Ventilation with Lower Tidal Volumes As Compared with Traditional Tidal Volumes for Acute Lung Injury and the Acute Respiratory Distress Syndrome NEJM 2000; 342: 1301-1308

26/7/16 Dr Bart Effects of Probiotics on the Incidence of Ventilator Associated Pneumonia in Critically Ill Patients: A Randomized Controlled Multicenter Trial Intensive Care Medicine 2016; 42: 1018-1028

Dr Yeo Ventricular Tachycardia Ablation Versus Escalation of Antiarrhythmic Drugs NEJM 2016; 375: 11-121

19/7/16 Dr Evans

A Critical Care Societies Collaborative Statement: Burnout Syndrome in Critical Care Health-care Professionals. A Call for Action American Journal of Respiratory and Critical Care Medicine 2016; 194(1): 106-113

Dr Asundi

High-Flow Nasal Oxygen vs Noninvasive Positive Airway Pressure in Hypoxemic Patients After Cardiothoracic Surgery: A Randomized Clinical Trial. JAMA May 2016. Published online first.



12/7/16 Dr Yeo Efficacy and Safety of Procalcitonin Guidance in Reducing the Duration of Antibiotic Treatment in Critically Ill Patients: A Randomised, Controlled, Open-label Trial Lancet Infectious Diseases 2016; 16: 819-827

Dr Abraham Discussion Against Use of Procalcitonin Testing

Dr Bart Discussion For Use of Procalcitonin Testing

5/7/16 Dr Davies

Randomized Evaluation of Fibrinogen vs Placebo In Complex Cardiovascular Surgery (REPLACE): a Double-Blind Phase III Study of Haemostatic Therapy British Journal of Anaesthesia 2016; 117(1): 41-51

28/6/16 Guest Speaker: Dr Alice Bourke

Delirium in Geriatric Patients

Dr Boyle

Effect of Aspirin on Development of ARDS in At-Risk Patients Presenting to the Emergency Department JAMA 2016; 315(22): 2406-2414

14/6/16 Dr Sundararajan Tracheostomy and Early Use of Speaking Valves

Dr Abraham

Intensive Blood-Pressure Lowering in Patients with Acute Cerebral Hemorrhage NEJM June 2016. Published online first.

7/6/16

Dr Davies Initiation Strategies for Renal Replacement Therapy in the Intensive Care Unit NEJM 2016; 375: 122-133

Dr Smith Effects of Early Versus Delayed Initiation of Renal Replacement Therapy on Mortality in Patients with Acute Kidney Injury (ELAIN) JAMA 2016; 315(20): 2190-2199

17/5/16 Guest speaker: Dr McRae

Thrombolysis in Pulmonary Embolism

10/5/16

Guest speaker: Dr Shorr

Strategic Options for Management of Difficult to Treat Gram Negative Infection. Are There Any New Options?

3/5/16 Dr Abraham Rapid Response Team and Hospital Mortality in Hospitalized Patients Intensive Care Med 2016; 42: 494-504

Dr Bart Transcatheter or Surgical Aortic Valve Replacement in Intermediate-Risk Patients NEJM 2016; 374: 1609-1620



26/4/16 Dr Wong Liberal or Restrictive Transfusion after Cardiac Surgery NEJM 2015; 372: 997-1008

19/4/16 Dr Asundi Rate Control versus Rhythm Control for Atrial Fibrillation after Cardiac Surgery NEJM April 2016. Published online first.

12/4/16 Dr Davies Effect of Noninvasive Ventilation on Tracheal Reintubation Among Patients With Hypoxemic Respiratory Failure Following Abdominal Surgery A Randomized Clinical Trial JAMA 2016; 315(13): 1345-1353

Dr Gluck Amiodarone, Lidocaine or Placebo in Out of Hospital Cardiac Arrest NEJM April 2016. Published online first.

Dr Wong Effect of Postextubation High-Flow Nasal Cannula vs Conventional Oxygen Therapy on Reintubation in Low-Risk Patients -A Randomized Clinical Trial JAMA 2016; 315(13): 1354-1361

5/4/16 Dr Yeo High Dose Perioperative Atorvastatin and Acute Kidney Injury Following Cardiac Surgery JAMA 2016; 315(9): 877-888

29/3/16 Dr Davies Dexmedetomidine for Treatment of Hyperactive Delirium Refractory to Haloperidol in Non-intubated ICU Patients: A Nonrandomised Controlled Trial Critical Care Medicine Feb 2016. Published online first.

Dr Gluck Perioperative Dexmedetomidine Reduces the Incidence and Severity of Acute Kidney Injury Following Valvular Heart Surgery. Kidney International 2016; 89(3): 693-700

Dr Wong Effect of Dexmedetomidine Added to Standard Care on Ventilator-Free Time in Patients with Agitated Delirium-A Randomised Clinical Trial JAMA March 2016. Published online first.

22/3/16 Dr Painter Stopping vs Continuing Aspirin Before Coronary Artery Surgery NEJM 2016; 374: 728-737

Dr Boyle Epidemiology, Patterns of Care and Mortality for Patients with Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries JAMA 2016; 315(8): 788-800

15/3/16 Dr Bart Literature review on Sepsis:



ProMISE-Trial of Early, Goal-Directed Resuscitation for Septic Shock. NEJM 2015; 372: 1301-1311 ARISE-Goal Directed Resuscitation for patient with Early Septic Shock. NEJM 2014; 371: 1496-1506 ProCESS- A Randomized Trial of Protocol Based Care for Early Septic Shock. NEJM 2014; 370: 1683-1693

8/3/16 Dr Abraham Chronology of Histological Lesions in Acute Respiratory Distress Syndrome with Diffuse Alveolar Damage: A Prospective Cohort Study of Clinical Autopsies Lancet Respiratory Medicine 2013; 1(5): 395-401

Dr Parasuraman Randomised Trial of Apneic Oxygenation during Endotracheal Intubation of the Critically Ill American Journal of Respiratory and Critical Care Medicine 2016; 193(3): 273-280

1/3/16 Dr Gluck The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) JAMA 2016; 315(8): 801-810

Dr Singh Refresher Guide to Sepsis: Old and New www.survivingsepsis.org

23/2/16 Dr Singh Identifying Critically Ill Patients Who Will Benefit Most From Nutritional Therapy: Further Validation of “Modified NUTRIC” Nutritional Assessment Tool Clinical Nutrition 2016; 35: 158-162

Dr Wong Restricted Versus Continued Standard Caloric Intake During the Management of Refeeding Syndrome in Critically Ill Adults: a Randomised, Parallel-group, Multicentre, Single-blind Controlled Trial Respiratory Medicine 2015; 3(12): 943-952

16/2/16 Dr Farquharson Very High Volume Hemofiltration with the Cascade system in Septic Shock Patients Intensive Care Medicine 2015; 41: 2111-2120

Dr Abraham Effect of Acetazolamide vs Placebo on Duration of Invasive Mechanical Ventilation Among Patients With Chronic Obstructive Pulmonary Disease - A Randomized Clinical Trial JAMA 2016; 315(5): 480-488

Dr Yeo Early High Volume Hemofiltration Versus Standard Care for Post-Cardiac Surgery Shock. The HEROICS Study American Journal of Respiratory and Critical Care Medicine 2015; 192(10): 1179-1190

http://www.survivingsepsis.org/



2/2/16 Dr Gluck Decompressive Hemicraniectomy in Patients with Malignant Middle Cerebral Artery Infarction: A Systematic Review and Meta-Analysis Surgeon 2015; 13(4): 230-240

Dr Wong Goad Directed Hemostatic Resuscitation of Trauma-Induced Coagulopathy: A Pragmatic Randomized Clinical Trial Comparing A Viscoelastic Assay to Conventional Coagulation Assay Annals of Surgery December 2015. Published online first.

12/1/16 Dr Yeo A Multicentre Randomized Trial of Continuous Versus Intermittent Beta-Lactam Dosing in Severe Sepsis American Journal of Respiratory and Critical Care Medicine 2015; 192(11): 1298-1305

8/12/15 Dr Gluck The UK ICS Guideline for Venous Thromboprophylaxis

Dr Wong NHMRC Guidelines on VTE Prophylaxis http://nhmrc.gov.au/guidelines-publications/cp115

Dr Yeo Dalteparin Versus Unfractionated Heparin in Critically Ill Patients (PROTECT Trial) New England Journal of Medicine 2011;364(14):1305-1314 Failure of anticoagulant thromboprophylaxis: Risk Factors in Surgical-Medical Critically Ill Patients Critical Care Medicine 2015; 43(2): 401-410

1/12/15 Dr Abraham Early Combination Antibiotic Therapy Yields Improved Survival Compared with monotherapy in Septic Shock: A Propensity-matched Analysis Critical Care Medicine 2010; 38(9): 1773-1785

Dr Strand Trial of Short Course Antimicrobial Therapy for Intra-abdominal Infection New England Journal of Medicine 2015; 372: 1996-2005

24/11/15 Dr Wurm Andexanet Alfa Reversal of Factor Xa Inhibitor Activity New England Journal of Medicine 2015; 373: 2413-2424

Dr Ahlstedt Impact of Time to Antibiotics on Survival in Patients with Severe Sepsis or Septic Shock in Whom Early Goal Directed Therapy was Initiated in Emergency Department Critical Care Medicine 2010; 38(4): 1045-1053

17/11/15 Dr Parasuraman Long Term Survival and Dialysis Dependency Following Acute Kidney Injury in Intensive Care: Extended Follow-up of a Randomised Controlled Trial PLOS 2014; 11(2): 1-13

http://nhmrc.gov.au/guidelines-publications/cp115



10/11/15 Dr Yeo Hypothermia in Intracranial Hypertension after Traumatic Brain Injury New England Journal of Medicine 2015; 373: 2403-2412

3/11/15 Dr Singh Effect of Buffered Crystalloid Solution versus Saline on Acute Kidney Injury Among Patients in the Intensive Care Unit- The SPLIT Randomized Clinical Trial JAMA 2015; 314(16): 1701-1710

13/10/15 Dr Abraham Rapid Diagnosis of Infection in the Critically Ill. A multicentre Study of Molecular Detection in Bloodstream Infection, Pneumonia and Sterile Site Infection’ Critical Care Medicine 2015; 43(11): 2283-2291

Dr Parasuraman Beta Blockers in Burns: Summary of Current Evidence

Dr Yeo Acetaminophen for Fever in Critically Ill Patients with Suspected Infection New England Journal of Medicine 2015; 373: 2215-2224

29/9/15 Dr Abraham Prophylaxis Against Post-operative Atrial Fibrillation in Patients Undergoing Cardiac Surgery- Current Evidence

Dr Yeo Skin Antisepsis with Chlorhexidine-Alcohol versus Povidone Iodine-Alcohol, with or without Skin Scrubbing, for Prevention of Intravascular Catheter Related Infection CLEAN): An Open-Label, Multicentre, Randomised, Controlled, Two-by-two Factorial Trial The Lancet 2015; 386: 2069-2077

15/9/15 Dr Yeo Initial Use of Tadalafil plus Ambrisentan in Pulmonary Hypertension New England Journal of Medicine 2015; 373: 834-844

1/9/15 Dr Yeo The Very Elderly Admitted to the ICU: A Quality Finish? Critical Care Medicine 2015; 43(7): 1352-1360

18/8/15 Dr Ahlstedt Esmolol Infusion in Septic Shock

Dr Gluck Lung-Protective Ventilation With Low Tidal Volume and the Occurrence of Pulmonary Complications in Patients Without Acute Respiratory Distress Syndrome: A Systematic Review and Individual Patient Data Analysis Critical Care Medicine 2015; 43(10): 2155-2163

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