raimund ubar

Tallinn University of TechnologyDepartment of Computer Engineering

Tallinn, September 16, 2013CEBE IAB-meeting

CEBE – Centre of Excellence for “Integrated Electronic Systems and

Biomedical Engineering“

Raimund Ubar

CEBE IAB-Meeting

Integreeritud elektroonikasüsteemide ja biomeditsiinitehnika tippkeskus© Raimund Ubar

International Advisory Board

WELCOME to TallinnMarta Rencz - Budapest University of Technology, HungaryBashir M. Al-Hashimi - University of Southampton, UKJürgen Bommer - Dialysezentrum Heidelberg, GermanyBernard Courtois - CMP, FranceRainer Dorsch - Bosch, GermanyManfred Glesner - TU Darmstadt, GermanyAhmed Jerraya - CEA-LETI, MINATEC, FranceJaakko Malmivuo - Tampere University of Technology, FinlandUwe Pliquett - Institut für Bioprozess- und Analytische Messtechnik, Germany

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Welcome

09:00 R.Ubar General Overview about CEBE

Presentations09:30 J.RaikResearch on Verification and Diagnosis FP7 DIAMOND

09:55 A.Jutman Research on Testing. FP7 BASTION

10:20 -10:50 Coffee

10:50 M.MinResearch on Signal Processing Cooperation with ELIKO Presentations

11:20 I.FridolinResearch on Biomedical Engineering Cooperation with hospitals

11:50 DISCUSSIONS

12:30 -14:00 Lunch

14:00 -15:30 Open lecture of Dr. Honoris Causa of TUT R. Kurki-Suonio

16:00 – 17:30 Discussions between IAB and CEBE management

Program


Overview

General about CEBE (position in Estonia, structure, research fields, new project activities, mission)

Slogan of CEBE – HEALTH2

Two types of synergy Overview about cooperation in CEBE Formal results (PhD defences, patents,

publications, projects, external cooperation)

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How CEBE Was Born

National program (EU Structural Funds):

„Development of Centres of Excellence in Research“

Period: 2008-2015

Number of candidates – 24

Each consortium consisted of research groups who had a target financed project (financed from Ministry of Education)

7 + 5 centres (in 2011) were selected

CEBE is one of the 12 Centres

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Estonian 12 Excellence Centres

2008

Tartu Genomics Chemical Biology Bio-diversity Research Translational Medicine Theory of Culture

Tallinn Computer Science CEBE

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2011

Tartu Mesosystems Dark Matter in Particle

Physics and Cosmology Environmental Adaptation High-Technology Materials

for Sustainable Development

Tallinn Nonlinear Studies


Mission of CEBE

Mission: Improvement of the quality of life through research and technological innovation Electronics and signal processing

Thomas Johan Seebeck Dept. of Electronics, TUT System design, test, and diagnostics

Dept. of Computer Engineering, TUT Engineering in biology and medicine

Technomedicum, TUT

Application directions: Mission-critical and dependable embedded systems Advancing medical-, food- and biotechnology Methods, algorithms & tools in signal processing, signal

interpretation, design of embedded systems, test and verification

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CEBE Steering Committee

Tallinn University of Technology

TJS DE DCE TM

CEBE Cooperation Projects

Structure of CEBE

IABARCHIMEDES


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Financial sources 2010 2011-2013 (average)

CEBE budget 583 29,6% 555 30,7%

Estonian sources 600 30,5% 513 28,3%

European projects 784 39,9% 743 41,0%

Total 1.967 100% 1.812 100%

Number of part-time researchers: 45 (22 full positions with average salary of 1400 Eur per month)

Number of doctorands: 64

Budget (thousands euros per year):

People and Budget


CEBE Competences

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Optical analysis

for dialysis

Interpretation of Biosignals

Investigation of brain signals

(EEG)

Quality of blood vessels

Impedance spectroscopy

Cardiacmonitors, stimulators

Signal processing algorithms

Semiconductor technology


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Health Risk Prevention by Technology

Sensors, equipments

Health diagnosis

toolDoctorsRisk

factorsRisks

Biosignals Healthcare plan


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eHealthMiddleware

Internet Gateway

Local DataConcentrator

Ambient Assisting Technologies

Generic Distributed ES Architectures


Slogan of CEBE - Health2

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Nested Health2 Management Concept

Medical equipments,

ICT

DOCTOR

PATIENT

Patient’s Health

Biomedical engineering

Design, Development

Repair

Test, VerificationDiagnosis

System Health

Medical knowledge


Bioimpedancespectrography& tomography

Brain research, EEG spectral

analysis

Optical dialysis monitoring

Optical pulse wave measurement

in arteries

Research in biomedical engineering

Signal processing algorithms

Design for low power, speed, cost, reliability

System design

Design of dedicated processors

Verification, design error automated

diagnosis and repair

Design for dependability

Automated testing and fault diagnosis

CEBE Research Towards Health2

Pacemakers

Mobile EEG analyser

Equipments foroptical signal measurement

Medical equipment

Applications

Information for doctors

Bioimpedance analysers


CEBE research topics

Verification, test and diagnosis (R.Ubar, J.Raik, A.Jutman)

Design of Embedded Systems (P.Ellervee, G.Jervan, Th.Hollstein)

Signal processing and bio-impedance spectroscopy (M.Min)

Semiconductor technology (T.Rang)

Optical Methods in Cardiology (K.Meigas)

Optical Methods in Dialysis (I.Fridolin)

Interpretation of Brain EEG Signals (H.Hinrikus)

Looking for Synergy > Internal Projects

P1

P2

P5

P4

P6

P3

P7

P8 Platform for Embedded System Design


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Cooperation Synergy

External impact:Applications

ComputerEngineering

Electronics

Technomedicum

EXPECTATIONs:(Two goals of CEBE)

Research excellence

Applications

Internal impact:Improved Research

Excellence


Cooperation Projects P1. Application Specific Processors for Signal Processing

in Biomedicine (E/CE – M.Min)

Results: Methods of signal generation and processing for broad-band impedance spectroscopy with implementations in medicine and engineering

New specific signal processor architectures (P.Ellervee)

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Products:Pacemakers (Cooperation with St.Jude Medical, USA)

Impedance-spectroscopy measurement equipment QUADRA (Cooperation with Enterprise Estonia, start-up company Prototuba OÜ)

Inventor prof. Mart Min was nominated among 3 selected candidates for the European Inventor Award 2011


Cooperation Projects

P2. Verification, debug, DFT of Systems (CE: D/V – R.Ubar/J.Raik)

Results: Methods for verification and automated debug of systems (J.Raik, M.Jenihhin)

Prototype: Fast fault simulator (speed-up 5-10 times, compared to commercial analogs) (S.Devadze)

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ROx xRIy

ySSBDDT)(

New testability marker, easily to be calculated from the circuit structure

Characterizes the circuit complexity



P2. Verification, debug, DFT (CE: D/V – R.Ubar/J.Raik)

Result: New family of benchmark circuits ordered by the complexity (by the values of the testability marker)

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a...

.

. b...

.

.

bk...

.

.

be...

.

.

bs...

.

.

c...

.

. d...

.

. de...

.

.

Shared preprocessorand integrator

Common buffersfor all channels

Shared prepocessorand shared integrator

Common buffersfor all channels

Shared preprocessor

Sharedpreprocessor

Shared adder/subtractorin the preprocessor

Initial design

Shared adder/subtractorin the preprocessor

and shared integrator

Added buffersfor every samplefor every channel

Sharing of resources Increase of complexity Complexity

Cost of processing (time)

Test generationFault simulationTest length



P2. Verification, debug, DFT (CE: D/V – R.Ubar/J.Raik)

Result: Novel at-speed on-line functional test method for signal processors (by using inherent specific signals instead of LFSRs or ATPG tests) (M.Gorev)

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Signal processor

LFSR

Sine

Chirp

Sawtooth

Fault coverage

Test length


HLDD Verification and Design Repair

Bug

P2. Verification, debug, DFT of systems

Specification

ImplementationSpecification Implementation

Decision Diagrams

Each graph is represented by unique polynomialsas a canonical model of the system

Novelty: A new possibility for formal verification of digital systems, design error detection and automated repair


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Managing the Complexity with HLDDs

A=FA1 (...)

B=FB1 (...)

C=FC1 (...)

A=FA2 (B,C,...)

A=FAn (D,E,...)

State space

Program data flow

Behavior of A

DE

B

C

High-Level Decision Diagrams

Novelty: Instead of reasoning the design as a whole, it will be partitioned into the behavioral sub-models of functional variables (HLDDs)



P3. Total Peripheral Resistance (E/TM – K.Meigas)

Results: Methods for continuous and noninvasive optical monitoring of blood pressure and diagnosis of atherosclerosis

Distinguishing high sudden death risk patients in various heart diseases

Product:Software for commercial Holter monitor devices

By spin-off company Tensiotrace OÜ, Estonia

Clinical experiments in the hospital PERH, Estonia

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P4. Evaluation of mental disorders using EEG analyser (CE/TM – M.Jenihhin/H.Hinrikus)

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Results: EEG spectral asymmetry index was invented (SASI algorithm), which allowed to develop a new method for determining depressive disorders by measuring EEG signals of the brain (H.Hinrikus)

Prototype: Portable EEG analyzer for detecting mental disorders (M.Jenihhin)

Clinical experiments are going on


Cooperation Projects P5. Reliable and disturbance free monitoring of dialysis

(CE/TM – I.Fridolin)

Results: Methods for multicomponent monitoring of uremic toxins in biofluids during dialysis

Product:

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Medical equipment for dialysis dose monitoring DiasensBy Enterprise Estonia, AS Ldiamon


Cooperation Projects P6. Testing of electronic systems (E/CE

– A.Jutman) Results: Methods and a system for automated test program

synthesis for electronic boards Methods and high-performance embedded instrumentation in

electronic boards Products:

• Microprocessor models for testing• Embedded instrumentation IPs for testing of PCBs and IC chips

(Göpel Electronics GmbH, Germany)• BERT (Bit-Error-Rate) Test Equipment

(CERN, Switzerland)

By spin-off Testonica Lab, Estonia 26



P7. Semiconductor Technology (T.Rang) Results: Two new approaches have been developed to increase

the yield in manufacturing of high speed GaAs power diodes

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Cooperation partners:• Ioffe Physical-Technical Inst. of

Russian Acad. of Sciences,• Power Electronics Dept. (TUT)

Products: High speed power GaAs

structures using the LPE technology By By Clifton Ltd, Estonia


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Defect0101

Conditional faultPattern fault

Constrained SAFSingle faulty signal

Resistive bridge fault

X-faultByzantine fault

BridgesStuck-opens

Multiple faulty signal

SAF

Multiple fault

P7. Semiconductor Technology (T.Rang, R.Ubar)

Goals: Defect-oriented Testing with advanced fault models


Dependable ES Design Platform

Novel methods in design for dependability:

Platform based design environment for dependable embedded systems Fault simulation Automated synthesis and

analysis of test programs System verification and design

error diagnosis Automated design error repair Dependability of NoC-based

System-on-Chips

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Algorithms, solutions

Signal source,sensors

Design space exploration

Prototype

Architectures,components


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Behavioral VHDL-Design

RTL VHDL-Design

High-Level Synthesis TTU

Logic-Level Synthesis Synopsys/Cadence

VHDL > DD

DD

Gate-Level EDIF Netlist

EDIF > SSBDD

SSBDD

Logic-Level ATPG TURBO-TESTER

Test

Hierarchical ATPG

DECIDER

EDIF ISCAS

Converter

Defect-Level ATPG DOT

Defect Library

ISCAS Netlist

University Software

Defect-Fault Analysis

TU Warsaw

ZamiaCAD Design FrameworkTTU/IBM/Zamia cooperation

HardwareVerificationFramework

APRICOT

Defect level

High level

Logic level

D&T Environment for Research

Possibility for wide range of experimental

scenarios


Europrojects during 2011-2015 FP7: - SAFEMETAL (2010 - 2012) FP7: - CREDES (2010 - 2012) FP7: Diagnosis, Error Modelling and Correction for Reliable Systems

Design - DIAMOND (2011 - 2013) FP7: - Innovative, Highly Efficient Road Surface Measurement and

Control System - HERMES (2012 - 2014) FP7: BASTION (2014 - 2016) – (CEBE + Testonica Lab)

Organized international conferences Baltic Electronic Conferences (2008, 2010, 2012) Nordic Test Forum (2011) IEEE Norchip Conference (2012), IEEE DDECS Workshop (2012) BELAS – European – LatinAmerican Workshop (2013) HiPEAC Computing Systems Week (2013)

CEBE International Cooperation

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Cooperation Partners of CEBE

The partners of CEBE in Estonian industry

• ELIKO, Artec Group, Smartimplant, Cybernetica AS, National Semiconductor Eesti, Clifton AS, JR Medical, Elcoteq, AS LDI, LDIAMON AS, Emros OÜ, Tensiotrace OÜ, Girf OÜ, AB Medical Teeninduse OÜ, a.o.

• 2 clinics , 4 Estonian hospitals International cooperation

• IBM, Ericsson, St. Jude Medical, Boston Scientific, National Semiconductor, Analog Devices, TDI Inc, Göpel Electronic, STMicroelectronics, AerieLogic, TransEda, a.o.

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Concluding Statistics

Some numbers about CEBE (last 4/5 years): 13 international projects (5 FP7), 25+ national grants 25 PhD thesis defended 452 publications (170 journal and 273 conf. papers) Cooperation with 10 industrial partners from Estonia and more

than 30 institutions from 15 countries 15 patents and 11 patent applications Spin-off companies: 4 (Testonica Lab, Tensiotrace OÜ,

Optofluid Technologies OÜ, Prototuba OÜ) Products: 9 International evalvation of CEBE (End of 2011)

Grade: 5 - Excellent (Application was 4,5)

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Thank you!

raimund ubar

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