Rakesh K. Jain Scientific American

Image of snake removed due to copyright restrictions. Source: Jain, Rakesh K. "An indirect way to tame cancer." Scientific American 310, no. 2 (2014): 46-53.

2014

1

Figures from Box 1 removed due to copyright restrictions. Source: Jain, Rakesh K. "An indirect way to tame cancer." Scientific American 310, no. 2 (2014): 46-53.

2

Figures from Box 2 removed due to copyright restrictions. Source: Jain, Rakesh K. "An indirect way to tame cancer." Scientific American 310, no. 2 (2014): 46-53.

3

Cortical myosin

assembly

Cortical actin

assembly

Courtesy of Macmillan Publishers Limited. Used with permission. Source: Charras, Guillaume T. et al. "Non-equilibration of hydrostatic pressure in blebbing cells." Nature 435, no. 7040 (2005): 365-369.

4

Cortical myosin

assembly

Microplast (cell fragment) volume remains constant during blebbing

Courtesy of Macmillan Publishers Limited. Used with permission. Source: Charras, Guillaume T. et al. "Non-equilibration of hydrostatic pressure in blebbing cells." Nature 435, no. 7040 (2005): 365-369.

5

Increasing extracellular osmolarity makes blebs smaller

Courtesy of Macmillan Publishers Limited. Used with permission. Source: Charras, Guillaume T. et al. "Non-equilibration of hydrostatic pressure in blebbing cells." Nature 435, no. 7040 (2005): 365-369.

6

Increasing membrane rigidity inhibits blebbing

Courtesy of Macmillan Publishers Limited. Used with permission. Source: Charras, Guillaume T. et al. "Non-equilibration of hydrostatic pressure in blebbing cells." Nature 435, no. 7040 (2005): 365-369.

7

cortical acto-myosin contraction bleb forms (rupture event)

pore-size or fluid flows mesh-size through pores due

to hydrostatic pressure

Courtesy of Macmillan Publishers Limited. Used with permission. Source: Charras, Guillaume T. et al. "Non-equilibration of hydrostatic pressure in blebbing cells." Nature 435, no. 7040 (2005): 365-369.

8

σ11

Figures 7.14 and 7.15 removed due to copyright restrictions. Source: Grodzinsky, Alan. Field, Forces and Flows in Biological Systems. Garland Science, 2011.

Fields, Forces, & Flows, Figures 7.14 & 7.15

9

MIT OpenCourseWare http://ocw.mit.edu

20.430J / 2.795J / 6.561J / 10.539J Fields, Forces, and Flows in Biological SystemsFall 2015

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